CN107412571A - 一种治疗羞明的药物及其制备方法 - Google Patents

一种治疗羞明的药物及其制备方法 Download PDF

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CN107412571A
CN107412571A CN201710793138.5A CN201710793138A CN107412571A CN 107412571 A CN107412571 A CN 107412571A CN 201710793138 A CN201710793138 A CN 201710793138A CN 107412571 A CN107412571 A CN 107412571A
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王文春
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Abstract

本发明公开了一种治疗羞明的药物及其制备方法，它主要是由蛇蜕、猪肝、野花生、庵摩勒、鹿衔草、楮实、朝天罐、紫花地丁、黑老虎、鹅不食草、蓝花参、蓬蘽、蒟酱叶、碎米柴、蜂窝草、榕须、蘡薁根、鲤鱼胆、马尾连、马齿苋子、菊花、水团花、老鼠担冬瓜、生藤、冬瓜藤、密蒙花、合掌消、杜仲、枸杞子、女贞子、合子草按一定重量配比制备而成，本发明具有补肝养血、散翳消肿、清热明目、凉血、润肝的功能，用于治疗羞明见效快，疗效好。

Description

一种治疗羞明的药物及其制备方法
技术领域
本发明涉及一种治疗羞明的药物及其制备方法，属中药领域。
技术背景
羞明是指眼睛因患角膜炎、虹膜炎等而怕见光的症状，亦指由视神经衰弱所引起的畏光症状。中医则认为羞明与风热上攻、阴虚血亏有关。由于西药治疗副作用大，因此人们对有效治疗羞明的中药药物存在极大的需求，至今为止，还没有发现关于本发明的有关报道。
发明内容
本发明人在祖传验方的基础上，又依据中医理论的研究和临床试验的反复验证，终于研究出有效治疗羞明的药物，从而完成了本发明。
本发明的目的就是提供一种更有效的治疗羞明的中药组合药物。
本发明的另一目的就是提供了该中药组合药物的制备方法。
本发明药物是选择蛇蜕、猪肝、野花生、庵摩勒、鹿衔草、楮实、朝天罐、紫花地丁、黑老虎、鹅不食草、蓝花参、蓬蘽、蒟酱叶、碎米柴、蜂窝草、榕须、蘡薁根、鲤鱼胆、马尾连、马齿苋子、菊花、水团花、老鼠担冬瓜、生藤、冬瓜藤、密蒙花、合掌消、杜仲、枸杞子、女贞子、合子草、石斛、决明子、青葙子进行组合制备的，将这些药物组合使得各药物功效产生协同作用，从而能够有效治疗羞明。其中选用蛇蜕是因为其性味甘咸，平，有毒，入肝经，有祛风，定惊，退翳，消肿，杀虫的功能，治小儿惊癎，喉风口疮，木舌重舌，目翳内障，疔疮，痈肿，瘰疬，腮腺炎，痔漏，疥癣。选用猪肝是因为其性味甘苦，温，入肝经，有补肝，养血，明目的功能，治血虚萎黄，夜盲，目赤，浮肿，脚气。选用野花生是因为其性凉，味苦甘，有祛风，清热，明目的功能。选用庵摩勒是因为其性味苦，甘，寒，入脾，胃二经，有化痰，生津，止咳，解毒的功能，治感冒发热，咳嗽咽痛，白喉，烦热口干。选用鹿衔草是因为其性味甘苦，温，入肝、肾二经，有补虚，益肾，祛风除湿，活血调经的功能，治虚弱咳嗽，劳伤吐血，风湿关节痛，崩漏，白带，外伤出血。选用楮实是因为其性味甘，寒，入肝、脾、肾经，有滋肾，清肝，明目的功能，治虚劳，目昏，目翳，水气浮肿。选用朝天罐是因为其性味酸涩，微寒，无毒，有补虚益肾，收敛止血的功能，治痨伤咳嗽出血，痢疾，下肢酸软，筋骨拘挛，小便失禁，白浊白带。选用紫花地丁是因为其性味苦、辛、寒，归心、肝经，有清热解毒，凉血消肿的功能，治疔疮肿毒，痈疽发背，丹毒，毒蛇咬伤。选用黑老虎是因为其性味辛，微苦，性温，有行气止痛，散瘀通络的功能，治产后瘀血腹痛，疝气痛。选用鹅不食草是因为其性味辛，温，入手太阴经气分，有祛风，散寒，胜湿，去翳，通鼻塞的功能，治感冒，寒哮，喉痹，百日咳，痧气腹痛，阿米巴痢，疟疾，疳泻，鼻渊，鼻肉，目翳涩痒，臁疮，疥癣，跌打。选用蓝花参是因为其性味甘，平，有益气补虚，祛痰，截疟的功能，治病后体虚，小儿疳积，支气管炎，肺虚咳嗽，疟疾，高血压病，白带。选用蓬蘽是因为其性味甘、酸、性温，归肝、肾经。有补肾益精，缩尿的功能，用于头目眩晕，多尿，阳痿，不育，须发早白，痈疽。选用蒟酱叶是因为其性味辛，温，有祛风燥湿，杀虫止痒的功能，治风寒咳嗽，胃痛，风毒脚气，子肿，疥癞，淡疹，脚癣，烫伤。选用碎米柴是因为其性味甘，平，有清热，利湿，解毒的功能，治泌尿系结石，慢性胃炎，慢性气管炎，小儿疳积，痈疽发背，痔疮，漆疮。选用蜂窝草是因为其性味苦辛，温，有解表，止咳，通经，明目的功能，治感冒，咳嗽，哮喘，百日咳，闭经，夜盲症，疥癣。选用榕须是因为其性味苦涩，平，有祛风清热，活血解毒的功能，治流感，百日咳，麻疹不透，扁桃体炎，眼结膜炎，痧气腹痛，风湿骨痛，鼻衄，血淋，跌打损伤。选用蘡薁根是因为其性味甘，平，无毒，有清湿热，消肿毒的功能，治黄疸，湿痹，热淋，痢疾，肿毒，瘰疬，跌打损伤。选用鲤鱼胆是因为其性味苦，寒，入走厥阴经，有清热明目，散翳消肿的功能，治目赤肿痛，青盲障翳，咽痛喉痹。选用马尾连是因为其性味寒，味苦，有清热燥湿，解毒的功能，治痢疾，肠炎，传染性肝炎，感冒，麻疹，痈肿疮疖，结膜炎。选用马齿苋子是因为其有明目的功能。选用菊花是因为其性味甘苦，凉，入肺，肝经，有疏风，消热，明目，解毒的功能，治头痛，眩晕，目赤，心胸烦热，疔疮，肿毒。选用水团花是因为其性味苦，平，有清热利湿，消瘀定痛，止血生肌的功能，治痢疾，湿热，湿热浮肿，痈肿疮毒，湿疹，烂脚，溃疡不敛，创伤出血。选用老鼠担冬瓜是因为其味甘淡，性凉，治鱼口便毒，为洗药。选用生藤是因为其性味甘辛，温，有解表温中，祛风通络的功能，治感冒，气管炎，胃痛，痞胀，风湿疼痛。选用冬瓜藤是因为其味苦，性寒，无毒，治肺热痰火，脱肛的功能。选用密蒙花是因为其性味甘，凉，入肝经，有祛风，凉血，润肝，明目的功能，治目赤肿痛，多泪羞明，青盲翳障，风弦烂眼。选用合掌消是因为其性味微苦，平，无毒，有清热，祛风湿，消肿解毒的功能，治急性胃肠炎，急性肝炎，风湿痛，偏头痛，便血，痈肿，湿疹。选用杜仲是因为其性味甘微辛，温，入肝、肾经，有补肝肾，强筋骨，安胎的功能，治腰脊酸疼，足膝痿弱，小便余沥，阴下湿痒，胎漏欲堕，高血压。选用枸杞子是因为其性味甘，平，有滋肾，润肺，补肝，明目的功能，治肝肾阴亏，腰膝酸软，头晕目眩，目昏多泪，虚劳咳嗽，消渴，遗精。选用女贞子是因为其性味苦甘，平，入肝、肾经，有补肝肾，强腰膝的功能，治阴虚内热，头晕，目花耳鸣，腰膝酸软，须发早白。选用合子草是因为其有小毒，治水肿，疳积，蛇咬伤。选用石斛是因为其性味甘淡微咸，寒，入有、肺、肾经，有生津益胃，清热养阴的功能，治热病伤津，口干烦喝，病后虚热，阴伤目暗。选用决明子是因为其性味苦甘，凉，入肝、肾经，有清肝，明目，利水，通便的功能，治风热赤眼，青盲，雀目，高血压，肝炎，肝硬化腹化，习惯性便秘。选用青葙子是因为其性味苦，凉，入肝经，有祛风热，清肝火的功能，治目赤肿痛，障翳，高血压，鼻衄，皮肤风热瘙痒，疥癞。
具体实施方式
本发明组方的药物用量也是发明人经过大量摸索总结得出的，各组分的用量在下述重量范围内都具有较好的疗效：
蛇蜕3-5克、猪肝250-300克、野花生30-40克、庵摩勒10-20克、鹿衔草10-20克、楮实10-20克、朝天罐30-40克、紫花地丁30-40克、黑老虎10-20克、鹅不食草10-15克、蓝花参10-20克、蓬蘽10-20克、蒟酱叶10-20克、碎米柴30-40克、蜂窝草10-20克、榕须10-20克、蘡薁根30-40克、鲤鱼胆3-9克、马尾连3-9克、马齿苋子10-15克、菊花10-20克、水团花10-15克、老鼠担冬瓜10-20克、生藤10-20克、冬瓜藤10-20克、密蒙花7-12克、合掌消25-35克、杜仲15-25克、枸杞子15-25克、女贞子15-25克、合子草30-40克、石斛10-15克、决明子10-15克、青葙子10-15克。
优选为：
蛇蜕3克、猪肝300克、野花生35克、庵摩勒15克、鹿衔草15克、楮实15克、朝天罐35克、紫花地丁35克、黑老虎15克、鹅不食草12克、蓝花参15克、蓬蘽15克、蒟酱叶15克、碎米柴35克、蜂窝草15克、榕须15克、蘡薁根35克、鲤鱼胆6克、马尾连6克、马齿苋子12克、菊花15克、水团花12克、老鼠担冬瓜15克、生藤15克、冬瓜藤15克、密蒙花9克、合掌消30克、杜仲20克、枸杞子20克、女贞子20克、合子草35克、石斛12克、决明子12克、青葙子12克。
本发明药物的制备方法如下：
一、备料
1、蛇蜕：用甘草水洗过，晒干，再用黄酒喷匀，置锅内微炒至黄色，每蛇蜕100斤，用酒5斤；
2、猪肝：取猪的肝脏，除去筋膜、胆管，洗净用；
3、野花生：春、夏季采挖，除去杂质，洗净，阴干；
4、庵摩勒：9-10月果熟时采收，晒干；
5、鹿衔草：拣去杂质，筛去泥沙，洗净，稍润，切细，晒干；
6、楮实：取原药材，筛去杂质，用时捣碎；
7、朝天罐：夏、秋采收；
8、紫花地丁：取原药材，除去杂质，洗净，稍晾，切段，干燥；
9、黑老虎：全年均可采，掘起根部及须根，洗净泥沙，切成小段或割取老藤茎，刮去栓皮，切段，晒干；
10、鹅不食草：拣净杂质，切段，晒干；
12、蓝花参：秋季采根，春、夏、秋采挖全草，晒干；
13、蓬蘽：秋季果实成熟时采收，晒干；
14、蒟酱叶：夏秋间采，洗净晒干；
15、碎米柴：夏、秋采收；
16、蜂窝草：夏、秋采收；
17、榕须：全年可采，割下气根，扎成小把，晒干；
18、蘡薁根：全年可采；
19、鲤鱼胆：将鲤鱼杀死后，取出胆囊，晾干；
20、马尾连：9-11月采挖，挖出后抖去泥沙，剪除茎苗，晒干；
21、马齿苋子：拣净杂质，晒干；
22、菊花：拣净叶梗、花柄及泥屑杂质；
23、水团花：随时可采，晒干用；
24、老鼠担冬瓜：拣净杂质，晒干；
25、生藤：夏、秋采集，切片晒干；
26、冬瓜藤：夏、秋采取，拣净杂质，晒干；
27、密蒙花：拣去杂质，筛净灰土；
28、合掌消：拣去杂质，切段，晒干；
29、杜仲：除去粗皮，洗净，润透，切成方块或丝条，晒干；
30、枸杞子：簸净杂质，摘去残留的梗和蒂；
31、女贞子：拣去杂质，洗净，晒干；
32、合子草：拣净杂质，晒干；
33、石斛：取干燥的石斛，用水泡约至八成透，闷润，除去残根及黑枝，切段，除去薄膜，晒干；
34、决明子：取净决明子，置锅内炒至微有香气，取出，放凉；
35、青葙子：8-10月采收，割取地上部分或花穗，搓去种子，除去杂质，晒干。
二、制备
1、取猪肝切薄片，烧存性，取出置于瓷盂中捣碎，再置于铁锅内加入黄酒3克和陈醋5克共同炒干，然后取出备用；
2、选蛇蜕和鲤鱼胆分别加入2克黄酒和3克陈醋置于铁锅中炒干，取出捣碎；
3、将野花生、庵摩勒、鹿衔草、楮实、朝天罐、紫花地丁、黑老虎、鹅不食草、蓝花参、蓬蘽、蒟酱叶、碎米柴、蜂窝草、榕须、蘡薁根、马尾连、马齿苋子、菊花、水团花、老鼠担冬瓜、生藤、冬瓜藤、密蒙花、合掌消、杜仲、枸杞子、女贞子、合子草、石斛、决明子、青葙子磨成碎药粉；
4、另取炼蜜200克，陈醋100克共同置于煎药容器内，煎煮10分钟，再入上述捣碎的和磨碎的药粉，用文火煎煮5分钟，混合搅拌均匀，置阴凉处阴干，即成散剂。
组方中蛇蜕祛风，定惊，退翳，消肿，杀虫，猪肝有补肝，养血，明目的功能二者为君药；野花生祛风，清热，明目，庵摩勒有化痰，生津，止咳，解毒的功能，与鹿衔草、楮实、朝天罐五味为臣药，七味药共同发挥补肝养血、退翳、清热明目、祛风、定惊的作用，治疗羞明效力全面，且以补肝养血、退翳、清热明目为主，可治本；鲤鱼胆有清热明目，散翳消肿的功能与紫花地丁、黑老虎、鹅不食草、蓝花参、逢蘽、蒟酱叶、碎米柴、蜂窝草、榕须、蘡薁根为佐药；密蒙花有祛风，凉血，润肝，明目的功能与余下诸药为使药，可治标。
本发明药物具有补肝养血、散翳消肿、清热明目、凉血、润肝的功能，用于治疗羞明见效快，疗效好，无副作用。
以下通过试验例来进一步阐述本发明药物的有益效果，这些试验包括本发明药物的动物毒性试验和临床疗效观察试验。
[试验例1]本发明药物的动物毒性试验
取家兔30只，雌雄兼用，体重2.0—2.5kg，分两组，每组15只，其中一组为超剂量试验组，另一组为正常量试验组。超常量组为0.4g/kg，正常量为0.2g/kg，给药方式为稀释灌胃法给药，每天两次，连服7天，每天观察给药反应，结果表明二组家兔活动、饮食正常，药物无不良毒副作用。
[试验例2]本发明药物的临床疗效观察
1、一般资料
收治门诊患者共28例。
2、诊断标准
羞明的症状包括：眼部红赤肿痛，眵多泪热和怕光等。
3、治疗方法
选用上述药物，给患者服用，每次12克，每天早、晚各服一次，7天为一疗程，连续服用3个疗程。
4、疗效评定标准
显效：羞明症状消失，恢复正常，痊愈；
好转：患者眼部红赤肿痛，眵多泪热和怕光的现象减轻，羞明症状明显好转，逐步恢复正常；
无效：达不到好转标准者。
5、治疗结果（见下表）：
在上述治疗中，用本发明药物治疗羞明患者28例，结果显效20例，显效率为71.42%，好转7例，好转率为25%，无效1例，总有效率为96.42%。

Claims (3)

1.一种治疗羞明的药物，其特征在于：它是由下列重量范围内的原料药制成：
蛇蜕3-5克、猪肝250-300克、野花生30-40克、庵摩勒10-20克、鹿衔草10-20克、楮实10-20克、朝天罐30-40克、紫花地丁30-40克、黑老虎10-20克、鹅不食草10-15克、蓝花参10-20克、蓬蘽10-20克、蒟酱叶10-20克、碎米柴30-40克、蜂窝草10-20克、榕须10-20克、蘡薁根30-40克、鲤鱼胆3-9克、马尾连3-9克、马齿苋子10-15克、菊花10-20克、水团花10-15克、老鼠担冬瓜10-20克、生藤10-20克、冬瓜藤10-20克、密蒙花7-12克、合掌消25-35克、杜仲15-25克、枸杞子15-25克、女贞子15-25克、合子草30-40克、石斛10-15克、决明子10-15克、青葙子10-15克。
2.根据权利要求1所述的药物，其中各原料药的用量为：
蛇蜕3克、猪肝300克、野花生35克、庵摩勒15克、鹿衔草15克、楮实15克、朝天罐35克、紫花地丁35克、黑老虎15克、鹅不食草12克、蓝花参15克、蓬蘽15克、蒟酱叶15克、碎米柴35克、蜂窝草15克、榕须15克、蘡薁根35克、鲤鱼胆6克、马尾连6克、马齿苋子12克、菊花15克、水团花12克、老鼠担冬瓜15克、生藤15克、冬瓜藤15克、密蒙花9克、合掌消30克、杜仲20克、枸杞子20克、女贞子20克、合子草35克、石斛12克、决明子12克、青葙子12克。
3.根据权利要求1或2所述药物的制备方法，其特征在于：它包括下列步骤：
（一）备料
（1）蛇蜕：用甘草水洗过，晒干，再用黄酒喷匀，置锅内微炒至黄色，每蛇蜕100斤，用酒5斤；
（2）猪肝：取猪的肝脏，除去筋膜、胆管，洗净用；
（3）野花生：春、夏季采挖，除去杂质，洗净，阴干；
（4）庵摩勒：9-10月果熟时采收，晒干；
（5）鹿衔草：拣去杂质，筛去泥沙，洗净，稍润，切细，晒干；
（6）楮实：取原药材，筛去杂质，用时捣碎；
（7）朝天罐：夏、秋采收；
（8）紫花地丁：取原药材，除去杂质，洗净，稍晾，切段，干燥；
（9）黑老虎：全年均可采，掘起根部及须根，洗净泥沙，切成小段或割取老藤茎，刮去栓皮，切段，晒干；
（10）鹅不食草：拣净杂质，切段，晒干；
（12）蓝花参：秋季采根，春、夏、秋采挖全草，晒干；
（13）蓬蘽：秋季果实成熟时采收，晒干；
（14）蒟酱叶：夏秋间采，洗净晒干；
（15）碎米柴：夏、秋采收；
（16）蜂窝草：夏、秋采收；
（17）榕须：全年可采，割下气根，扎成小把，晒干；
（18）蘡薁根：全年可采；
（19）鲤鱼胆：将鲤鱼杀死后，取出胆囊，晾干；
（20）马尾连：9-11月采挖，挖出后抖去泥沙，剪除茎苗，晒干；
（21）马齿苋子：拣净杂质，晒干；
（22）菊花：拣净叶梗、花柄及泥屑杂质；
（23）水团花：随时可采，晒干用；
（24）老鼠担冬瓜：拣净杂质，晒干；
（25）生藤：夏、秋采集，切片晒干；
（26）冬瓜藤：夏、秋采取，拣净杂质，晒干；
（27）密蒙花：拣去杂质，筛净灰土；
（28）合掌消：拣去杂质，切段，晒干；
（29）杜仲：除去粗皮，洗净，润透，切成方块或丝条，晒干；
（30）枸杞子：簸净杂质，摘去残留的梗和蒂；
（31）女贞子：拣去杂质，洗净，晒干；
（32）合子草：拣净杂质，晒干；
（33）石斛：取干燥的石斛，用水泡约至八成透，闷润，除去残根及黑枝，切段，除去薄膜，晒干；
（34）决明子：取净决明子，置锅内炒至微有香气，取出，放凉；
（35）青葙子：8-10月采收，割取地上部分或花穗，搓去种子，除去杂质，晒干；
（二）制备
（1）取猪肝切薄片，烧存性，取出置于瓷盂中捣碎，再置于铁锅内加入黄酒3克和陈醋5克共同炒干，然后取出备用；
（2）选蛇蜕和鲤鱼胆分别加入2克黄酒和3克陈醋置于铁锅中炒干，取出捣碎；
（3）将野花生、庵摩勒、鹿衔草、楮实、朝天罐、紫花地丁、黑老虎、鹅不食草、蓝花参、蓬蘽、蒟酱叶、碎米柴、蜂窝草、榕须、蘡薁根、马尾连、马齿苋子、菊花、水团花、老鼠担冬瓜、生藤、冬瓜藤、密蒙花、合掌消、杜仲、枸杞子、女贞子、合子草、石斛、决明子、青葙子磨成碎药粉；
（4）另取炼蜜200克，陈醋100克共同置于煎药容器内，煎煮10分钟，再入上述捣碎的和磨碎的药粉，用文火煎煮5分钟，混合搅拌均匀，置阴凉处阴干，即成散剂。
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Publication number Priority date Publication date Assignee Title
CN101269156A (zh) * 2008-05-22 2008-09-24 孟广千 治疗眼疾病的中药组合物
CN105596544A (zh) * 2016-01-02 2016-05-25 红河州吉昌生物科技有限公司 改进型补肝明目胶囊
CN106994155A (zh) * 2017-06-13 2017-08-01 湖南云从科技有限公司 一种治疗眼疲劳的药物配方及其制备方法

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101269156A (zh) * 2008-05-22 2008-09-24 孟广千 治疗眼疾病的中药组合物
CN105596544A (zh) * 2016-01-02 2016-05-25 红河州吉昌生物科技有限公司 改进型补肝明目胶囊
CN106994155A (zh) * 2017-06-13 2017-08-01 湖南云从科技有限公司 一种治疗眼疲劳的药物配方及其制备方法

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