CN107412510B - A kind of Chinese medicine composition with tonifying both YIN and YANG effect and preparation method thereof - Google Patents
A kind of Chinese medicine composition with tonifying both YIN and YANG effect and preparation method thereof Download PDFInfo
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- CN107412510B CN107412510B CN201710296919.3A CN201710296919A CN107412510B CN 107412510 B CN107412510 B CN 107412510B CN 201710296919 A CN201710296919 A CN 201710296919A CN 107412510 B CN107412510 B CN 107412510B
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- chinese medicine
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- medicine composition
- yin
- tonifying
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- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
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Abstract
The present invention provides a kind of Chinese medicine composition with tonifying both YIN and YANG effect, includes the preparing raw material of following parts by weight：Semen Cuscutae 120~135, barrenwort 50~80, teasel root 100~120, cynomorium songaricum 120~140, rhizoma cibotii 150~165, spina date seed 100~110, prepared fleece flower root 155~165, honey-fried licorice root 50~55, dried orange peel 50~60, deer horn glue 20~30, prepared rhizome of rehmannia 180~210, colla carapacis et plastri testudinis 30~40, the fruit of Cherokee rose 120~135, astragalus root 100~110, Chinese yam 100~120, raspberry 200~220.The invention belongs to technical field of traditional Chinese medicine preparation, there is Chinese medicine composition provided by the invention significant tonifying both YIN and YANG to act on, and have significant therapeutic effect to kidney deficiency and ovulation failure.
Description
Technical field
The invention belongs to technical field of traditional Chinese medicine preparation, more particularly to a kind of Chinese medicine composition with tonifying both YIN and YANG effect and
Its preparation method.
Background technology
The kidney being the origin of congenital constitution, is the basic of human life, and in the vital movement of human body, kidney yin kidney yang plays the work of key
With if the kidney yin insufficiency of the kidney yang or yin and yang imbalance, all making body produce pathological change, kidney theoretical according to traditional Chinese medical science coordination between the heart and kidney
Asthenic yin, the partially anti-symptom that the internal heats such as vexed insomnia, palpitaition can be caused prosperous of kidney yang.Western medicine is often cured the symptoms, not the disease at present,
The effect of general nourishing without conditioning, and side effect is big, it is expensive.
GUILU BUSHEN WAN is a kind of classical Chinese patent drug made of the Six-element medicinal material of Semen Cuscutae, barrenwort and teasel root etc. ten, tool
Strengthen the bone, replenishing qi and blood and the effect of kidney tonifying, in poor health, metal fatigue, lassitude in loin and legs, have a dizzy spell, many nights many urine,
The diseases such as forgetful insomnia.In addition to GUILU BUSHEN WAN, that develops listing has Guilubushen Capsules, Guilubushen Tablet and tortoise deer kidney tonifying
Oral liquid.
Chinese patent application CN 1365808 discloses a kind of nano medicine ' Guilu Bushen ', using Semen Cuscutae, excessive sheep
The nano raw material of the Six-element medicinal material of the leaves of pulse plants and teasel root etc. ten is made, and preparation method includes：Formula Chinese drug material Preparation process is selected in
Medicine medicine materical crude slice, add water or ethanol as solvent and import microwave abstracting, extract is concentrated under reduced pressure, collect concentrate and volatile
Material, dried with hypersonic velocity instantaneous jet, manufactured medicine particle diameter is in 0.1-200nm, it is not necessary to auxiliary material is added, but it is not right
The dregs of a decoction after extraction are studied and utilized, and undisclosed efficacy data, it is difficult to confirm drug effect.
The content of the invention
To solve problems of the prior art, the dregs of a decoction after inventor is extracted by lot of experiments to ingredients enter
Toxicity Analysis after row constituent analysis and backfill, it has been unexpectedly found that：Pass through the medicine after boiling barrenwort and prepared rhizome of rehmannia decocting
Slag is together used as medicine with decocting liquid, increases the dosage of prepared rhizome of rehmannia, can significantly reduce the dosage of barrenwort, realizes the reasonable utilization of the dregs of a decoction,
Cost is reduced, there is obtained Chinese medicine composition significant tonifying both YIN and YANG to act on, and has to kidney deficiency and ovulation failure and significantly controls
Therapeutic effect.Based on above-mentioned discovery, so as to complete the present invention.
The purpose of the present invention will be further described in detail below reflect and description.
The present invention provides a kind of Chinese medicine composition with tonifying both YIN and YANG effect, includes the preparation original of following parts by weight
Material：Semen Cuscutae 120~135, barrenwort 50~80, teasel root 100~120, cynomorium songaricum 120~140, rhizoma cibotii 150~165, spina date seed
100~110, prepared fleece flower root 155~165, honey-fried licorice root 50~55, dried orange peel 50~60, deer horn glue 20~30, prepared rhizome of rehmannia 180~
210th, colla carapacis et plastri testudinis 30~40, the fruit of Cherokee rose 120~135, astragalus root 100~110, Chinese yam 100~120, raspberry 200~220.
The combination of said components and the mass fraction of each component, it is that inventor is determined by lot of experiments, above-mentioned group
Close and mass fraction makes Chinese medicine composition provided by the invention that there is significant tonifying both YIN and YANG to act on, to kidney deficiency and ovulation failure
With significant therapeutic effect.
Chinese medicine composition provided by the invention with tonifying both YIN and YANG effect both mends people using colla carapacis et plastri testudinis, deer horn glue as monarch drug in a prescription
Body kidney the yang aspect of yang gas, human body kidney the yin aspect of yin essence is mended again；Prepared rhizome of rehmannia, prepared fleece flower root match somebody with somebody colla carapacis et plastri testudinis to strengthen the power of tonifying kidney and benefiting sperm, Tu
Silk, barrenwort, teasel root, cynomorium songaricum, rhizoma cibotii etc., to strengthen the effect of tonifying kidney and strengthening yang, are altogether ministerial drug with deer horn glue；The fruit of Cherokee rose, raspberry
Reinforcing the kidney and controlling noctural emission；Astragalus root, Chinese yam air making-up and spleen enlivening；Spina date seed mental-tranquilization；Dried orange peel promoting the circulation of qi invigorating the spleen, and make it is above-mentioned it is all build up one's health by taking tonic without
It is greasy, with aid digestion, absorption, altogether for adjutant；Radix glycyrrhizae adjusts medicine with, to make medicine.All medicines share, altogether into kidney-replenishing, benefiting essence-blood, gentle
Blood, the work(for adjusting negative and positive, for the metal fatigue caused by damage of kidney-essence, derangement of Qi and blood, imbalance of yin and yang, dizziness and tinnitus, lassitude in loin and legs,
The diseases such as sexual hypoesthesia, night pollakiuria, palpitation, forgetful insomnia.Chinese medicine composition provided by the invention adheres to traditional Chinese medical science negative and positive and put down
Weighing apparatus is theoretical, and clinical therapeutic efficacy is good, and curative effect is stable, has no toxic side effect, and takes securely and reliably, cheap.
Preferably, the described Chinese medicine composition with tonifying both YIN and YANG effect, the preparing raw material of following parts by weight is included：
Semen Cuscutae 120~130, barrenwort 60~70, teasel root 100~115, cynomorium songaricum 125~130, rhizoma cibotii 155~165, spina date seed 100
~110, prepared fleece flower root 155~165, honey-fried licorice root 50~55, dried orange peel 50~55, deer horn glue 20~25, prepared rhizome of rehmannia 190~210, tortoise
First glue 30~38, the fruit of Cherokee rose 120~135, astragalus root 100~110, Chinese yam 100~110, raspberry 205~220.
Preferably, the described Chinese medicine composition with tonifying both YIN and YANG effect, the preparing raw material of following parts by weight is included：
It is Semen Cuscutae 128, barrenwort 66, teasel root 106, cynomorium songaricum 128, rhizoma cibotii 160, spina date seed 106, prepared fleece flower root 160, honey-fried licorice root 53, old
Skin 53, deer horn glue 23, prepared rhizome of rehmannia 200, colla carapacis et plastri testudinis 34, the fruit of Cherokee rose 128, astragalus root 106, Chinese yam 106, raspberry 213.
Preferably, the Semen Cuscutae is fries Semen Cuscutae, and the barrenwort is steams barrenwort, and the teasel root is interrupted to steam, institute
Cynomorium songaricum is stated to steam cynomorium songaricum, the rhizoma cibotii is steams rhizoma cibotii, and the spina date seed is Semen Ziziphi Spinosae (parched), and the dried orange peel is to steam dried orange peel, the deer
Angle glue is fries deer horn glue, and the colla carapacis et plastri testudinis is fries colla carapacis et plastri testudinis, and the fruit of Cherokee rose is steams the fruit of Cherokee rose, and the Chinese yam is stir-baked RHIZOMA DIOSCOREAE, institute
Raspberry is stated to steam raspberry.By the processing that above-mentioned medicinal material is fried or steamed, beneficial to the enhancing of security performance and drug effect.Fry
Semen Cuscutae can also be expressed as Semen Cuscutae (stir-fry), and barrenwort (steaming) can be also expressed as by steaming barrenwort.
Preferably, the described Chinese medicine composition with tonifying both YIN and YANG effect, its preparation method comprise the following steps：
1) dried orange peel, Chinese yam, honey-fried licorice root, colla carapacis et plastri testudinis and deer horn glue are weighed, is crushed after mixing, obtains traditional Chinese medicine fine powder；
2) Semen Cuscutae, teasel root, cynomorium songaricum, rhizoma cibotii, spina date seed, prepared fleece flower root, the fruit of Cherokee rose, astragalus root and raspberry are weighed, is mixed
Crush, add water to cook twice, every time 1~3h after even, amount of water is 6~10 times of weight of medicinal material, filtration, decocting liquid merging, is obtained
First decocting liquid；Barrenwort and prepared rhizome of rehmannia are weighed, is crushed after mixing, is added water to cook twice, every time 1~3h, amount of water is the 6 of medicinal material
~10 times of weight, filtration, decocting liquid merge, and obtain the second decocting liquid, the dregs of a decoction are standby；Merge first decocting liquid and described second to decoct
Liquid, is condensed into medicinal extract, and drying obtains dried cream powder；
3) dregs of a decoction crushed after being dried is added the traditional Chinese medicine fine powder and the dried cream powder, mixes, had into fine powder
There is the Chinese medicine composition that tonifying both YIN and YANG acts on.
The price of barrenwort is about 85~100 yuan/kg, and the price of prepared rhizome of rehmannia is about 15~25 yuan/kg, and the present invention carries
The Chinese medicine composition tablet of confession and Guilubushen Tablet agent (dosage of barrenwort is larger, and the dregs of a decoction, which do not backfill, to be used as medicine) phase of prior art
Than cost reduces by 2~6%, can mitigate the economic pressures of patient.In view of raspberry and expensive, the inventor of spina date seed
The rear dregs of a decoction are boiled to its decocting first and are analyzed and backfilled trial, but drug effect can not be strengthened, even result in drug effect decrease, therefore not
Backfilled and be used as medicine.
Preferably, the relative density of the medicinal extract is 1.10~1.38.
Preferably, the Chinese medicine composition with tonifying both YIN and YANG effect adds pharmaceutically acceptable auxiliary material, is made into
Tablet.Pharmaceutically acceptable auxiliary material includes starch and magnesium stearate.
Correspondingly, the present invention also provides the preparation method of the Chinese medicine composition with tonifying both YIN and YANG effect, including following step
Suddenly：
S1 weighs dried orange peel, Chinese yam, honey-fried licorice root, colla carapacis et plastri testudinis and deer horn glue, is crushed after mixing, obtains traditional Chinese medicine fine powder；
S2 weighs Semen Cuscutae, teasel root, cynomorium songaricum, rhizoma cibotii, spina date seed, prepared fleece flower root, the fruit of Cherokee rose, astragalus root and raspberry, mixes
Crush, add water to cook twice, every time 1~3h after even, amount of water is 6~10 times of weight of medicinal material, filtration, decocting liquid merging, is obtained
First decocting liquid；Barrenwort and prepared rhizome of rehmannia are weighed, is crushed after mixing, is added water to cook twice, every time 1~3h, amount of water is the 6 of medicinal material
~10 times of weight, filtration, decocting liquid merge, and obtain the second decocting liquid, the dregs of a decoction are standby；Merge first decocting liquid and described second to decoct
Liquid, is condensed into medicinal extract, and drying obtains dried cream powder；
The dregs of a decoction are ground into fine powder by S3, add the traditional Chinese medicine fine powder and the dried cream powder, are mixed, and obtain having the moon
Sun and the Chinese medicine composition of benefit effect.
Preferably, the relative density of the medicinal extract is 1.10~1.38.Preferably, it is described to have in tonifying both YIN and YANG effect
Drug composition adds pharmaceutically acceptable auxiliary material, is made into tablet.Pharmaceutically acceptable auxiliary material includes starch and stearic acid
Magnesium.
Compared with prior art, the beneficial effects of the invention are as follows：(1) present invention is by the way that barrenwort and prepared rhizome of rehmannia decocting are boiled
The dregs of a decoction afterwards are together used as medicine with decocting liquid, increase the dosage of prepared rhizome of rehmannia, can significantly reduce the dosage of barrenwort, realize the part dregs of a decoction
Reasonable utilization, reduce cost, security is good；(2) the taste medicinal material of colla carapacis et plastri testudinis and deer horn glue etc. 5, is directly used as medicine, keeps away after crushed
The loss of active component in monarch drug in a prescription is exempted from, and has been acted synergistically with water boiling and extraction thing, barrenwort and the prepared rhizome of rehmannia dregs of a decoction, had
Significant tonifying both YIN and YANG effect, has significant therapeutic effect to kidney deficiency and ovulation failure, applied widely；(3) it is of the invention
Preparation method is simple, short preparation period, improves production efficiency.
Embodiment
Below by specific embodiment, the present invention is described in further detail.
In the present invention, involved preparing raw material is conventional commercial product, or can pass through ordinary skill in the art hand
Section obtains.
Embodiment one has the Chinese medicine composition of tonifying both YIN and YANG effect
Chinese medicine composition with tonifying both YIN and YANG effect, include the preparing raw material of following parts by weight：Semen Cuscutae (stir-fry)
128th, barrenwort (steaming) 66, teasel root (steaming) 106, cynomorium songaricum (steaming) 128, rhizoma cibotii (steaming) 160, spina date seed (stir-fry) 106, prepared fleece flower root
160th, honey-fried licorice root 53, dried orange peel (steaming) 53, deer horn glue (stir-fry) 23, prepared rhizome of rehmannia 200, colla carapacis et plastri testudinis (stir-fry) 34, the fruit of Cherokee rose (steaming) 128, process
The Radix Astragali 106, Chinese yam (stir-fry) 106, raspberry (steaming) 213.
The preparation method of Chinese medicine composition with tonifying both YIN and YANG effect comprises the following steps：
S1 weighs dried orange peel, Chinese yam, honey-fried licorice root, colla carapacis et plastri testudinis and deer horn glue, is crushed after mixing, obtains traditional Chinese medicine fine powder；
S2 weighs Semen Cuscutae, teasel root, cynomorium songaricum, rhizoma cibotii, spina date seed, prepared fleece flower root, the fruit of Cherokee rose, astragalus root and raspberry, mixes
Crushed after even, add water to cook twice, be for the first time 2h, amount of water is 8 times of weight of medicinal material, and second is 1h, and amount of water is medicine
6 times of weight of material, filtration, decocting liquid merge, and obtain the first decocting liquid；Barrenwort and prepared rhizome of rehmannia are weighed, crushes, adds water to cook after mixing
Twice, it is for the first time 2h, amount of water is 8 times of weight of medicinal material, and second is 1h, and amount of water is 6 times of weight of medicinal material, is filtered,
Decocting liquid merges, and obtains the second decocting liquid, the dregs of a decoction are standby；Merge first decocting liquid and second decocting liquid, 60 DEG C are concentrated under reduced pressure into
Relative density is 1.22 medicinal extract, and drying obtains dried cream powder；
The dregs of a decoction are ground into fine powder by S3, add the traditional Chinese medicine fine powder and the dried cream powder, are mixed, and cross 100 mesh sieves,
Obtain the Chinese medicine composition that there is tonifying both YIN and YANG to act on.
Further, the Chinese medicine composition addition appropriate amount of starch with tonifying both YIN and YANG effect, is made particle, adds
Appropriate magnesium stearate, tabletting after mixing, obtains Chinese medicine composition tablet.
Embodiment two has the Chinese medicine composition of tonifying both YIN and YANG effect
Chinese medicine composition with tonifying both YIN and YANG effect, include the preparing raw material of following parts by weight：Semen Cuscutae (stir-fry)
122nd, barrenwort (steaming) 60, teasel root (steaming) 115, cynomorium songaricum (steaming) 125, rhizoma cibotii (steaming) 155, spina date seed (stir-fry) 110, prepared fleece flower root
155th, honey-fried licorice root 50, dried orange peel (steaming) 55, deer horn glue (stir-fry) 20, prepared rhizome of rehmannia 210, colla carapacis et plastri testudinis (stir-fry) 30, the fruit of Cherokee rose (steaming) 120, process
The Radix Astragali 110, Chinese yam (stir-fry) 100, raspberry (steaming) 210.
Preparation method is similar with embodiment one.
Embodiment three has the Chinese medicine composition of tonifying both YIN and YANG effect
Chinese medicine composition with tonifying both YIN and YANG effect, include the preparing raw material of following parts by weight：Semen Cuscutae (stir-fry)
130th, barrenwort (steaming) 66, teasel root (steaming) 115, cynomorium songaricum (steaming) 130, rhizoma cibotii (steaming) 165, spina date seed (stir-fry) 100, prepared fleece flower root
165th, honey-fried licorice root 55, dried orange peel (steaming) 50, deer horn glue (stir-fry) 25, prepared rhizome of rehmannia 190, colla carapacis et plastri testudinis (stir-fry) 38, the fruit of Cherokee rose (steaming) 135, process
The Radix Astragali 100, Chinese yam (stir-fry) 110, raspberry (steaming) 215.
Preparation method is similar with embodiment one.
Comparative example 1
Chinese medicine composition includes the preparing raw material of following parts by weight：Semen Cuscutae (stir-fry) 128, barrenwort (steaming) 66, teasel root
(steaming) 106, cynomorium songaricum (steaming) 128, rhizoma cibotii (steaming) 160, spina date seed (stir-fry) 106, prepared fleece flower root 160, honey-fried licorice root 53, dried orange peel (steaming)
53rd, deer horn glue (stir-fry) 23, prepared rhizome of rehmannia 200, colla carapacis et plastri testudinis (stir-fry) 34, the fruit of Cherokee rose (steaming) 128, astragalus root 106, Chinese yam (stir-fry) 106, cover
Basin (steaming) 213.
The preparation method of Chinese medicine composition comprises the following steps：
S1 weighs dried orange peel, Chinese yam, honey-fried licorice root, colla carapacis et plastri testudinis and deer horn glue, is crushed after mixing, obtains traditional Chinese medicine fine powder；
S2 weighs Semen Cuscutae, teasel root, cynomorium songaricum, rhizoma cibotii, spina date seed, prepared fleece flower root, the fruit of Cherokee rose, astragalus root, raspberry, excessive
The sheep leaves of pulse plants and prepared rhizome of rehmannia, crush, added water to cook twice after mixing, be for the first time 2h, amount of water is 8 times of weight of medicinal material, for the first time
For 1h, amount of water is 6 times of weight of medicinal material, and filtration, decocting liquid merging, 60 DEG C are concentrated under reduced pressure into the medicinal extract that relative density is 1.22,
Drying obtains dried cream powder；
S3 adds the traditional Chinese medicine fine powder and the dried cream powder, mixes, and crosses 100 mesh sieves, obtains having what tonifying both YIN and YANG acted on
Chinese medicine composition.
Further, obtained Chinese medicine composition addition appropriate amount of starch, is made particle, adds appropriate magnesium stearate, mix
Tabletting after even, obtains Chinese medicine composition tablet.
The difference of comparative example 1 and embodiment one is：The dregs of a decoction after barrenwort and prepared rhizome of rehmannia decocting are boiled are not backfilled and are used as medicine.
Comparative example 2
Chinese medicine composition includes the preparing raw material of following parts by weight：Semen Cuscutae (stir-fry) 128, barrenwort (steaming) 66, teasel root
(steaming) 106, cynomorium songaricum (steaming) 128, rhizoma cibotii (steaming) 160, spina date seed (stir-fry) 106, prepared fleece flower root 160, honey-fried licorice root 53, dried orange peel (steaming)
53rd, deer horn glue (stir-fry) 23, prepared rhizome of rehmannia 200, colla carapacis et plastri testudinis (stir-fry) 34, the fruit of Cherokee rose (steaming) 128, astragalus root 106, Chinese yam (stir-fry) 106, cover
Basin (steaming) 213.
The preparation method of Chinese medicine composition comprises the following steps：
S1 weighs dried orange peel, Chinese yam, honey-fried licorice root, colla carapacis et plastri testudinis, deer horn glue, Semen Cuscutae, teasel root, cynomorium songaricum, rhizoma cibotii, spina date seed, system
The fleece-flower root, the fruit of Cherokee rose, astragalus root and raspberry, crush, added water to cook twice after mixing, be for the first time 2h, amount of water is medicinal material
8 times of weight, second be 1h, and amount of water is 6 times of weight of medicinal material, filtration, decocting liquid merging, obtains the first decocting liquid；Weigh excessive
The sheep leaves of pulse plants and prepared rhizome of rehmannia, crush, added water to cook twice after mixing, be for the first time 2h, amount of water is 8 times of weight of medicinal material, for the second time
For 1h, amount of water is 6 times of weight of medicinal material, filtration, decocting liquid merging, obtains the second decocting liquid, the dregs of a decoction are standby；Merge described first to decoct
Liquid and second decocting liquid, 60 DEG C are concentrated under reduced pressure into the medicinal extract that relative density is 1.22, and drying obtains dried cream powder；
The dregs of a decoction are ground into fine powder by S2, add the dried cream powder, are mixed, and are crossed 80 mesh sieves, are obtained with tonifying both YIN and YANG
The Chinese medicine composition of effect.
Further, obtained Chinese medicine composition addition appropriate amount of starch, is made particle, adds appropriate magnesium stearate, mix
Tabletting after even, obtains Chinese medicine composition tablet.
The difference of comparative example 2 and embodiment one is：Dried orange peel, Chinese yam, honey-fried licorice root, colla carapacis et plastri testudinis and deer horn glue are after decocting is boiled
It is used as medicine.
The analysis of the dregs of a decoction of test example one
Respectively to Semen Cuscutae, teasel root, cynomorium songaricum, rhizoma cibotii, spina date seed, prepared fleece flower root, the fruit of Cherokee rose, astragalus root, raspberry, excessive sheep
The dregs of a decoction after the decocting of the leaves of pulse plants and prepared rhizome of rehmannia is boiled carry out the detection of active component and backfill is used as medicine investigation.As a result find：Barrenwort
Contain more icariin, Epimedin B and epimedium brevicornum polysaccharide isoreactivity composition in the dregs of a decoction, being found through the test of pesticide effectiveness can be to excessive sheep
The function that active component is boiled in leaves of pulse plants decocting plays supplementary function, can strengthen drug effect after backfill, and will not cause safety issue；Cultivated land
Contain more 5 hydroxymethyl furfural in xanthate slag, find that the function that active component can be boiled to prepared rhizome of rehmannia decocting rises through the test of pesticide effectiveness
To supplementary function, drug effect can be strengthened after backfill, and safety issue will not be caused；In the rhizoma cibotii dregs of a decoction containing more phenolic acid class and
Amino acids, but can not strengthen drug effect after backfilling；Contain more ursolic acid and cynomorium songaricum polysaccharide in the cynomorium songaricum dregs of a decoction, but return
Drug effect can not be strengthened after filling out；Contain more phytosterol and polysaccharide from Cuscuta chinensis in the Semen Cuscutae dregs of a decoction, but can not strengthen after backfilling
Drug effect；In addition, the dregs of a decoction of teasel root and spina date seed etc. can not also strengthen drug effect after backfilling respectively.Therefore, the backfill of the dregs of a decoction is not
Assume as a matter of course or it will be apparent that final screening determines that the dregs of a decoction backfill after boiling barrenwort and prepared rhizome of rehmannia decocting is used as medicine.
The safety testing of test example two
It is acute to embodiment one to embodiment three, and the progress of the Chinese medicine composition tablet of comparative example 1 and comparative example 2 respectively
Toxicity and long term toxicity are investigated.By 28g/kg dosage (equivalent to more than 500 times of people's conventional amount used) gavage mouse, observation 7
My god, as a result mouse normally survives, and anatomical results and Main Biochemical are normal, illustrates Chinese medicine composition provided by the invention
Without acute toxicity；By 5g/kg dosage (equivalent to 100 times or so of people's conventional amount used) continuous gavage mouse 6 months, see respectively
The mouse situation of 1 month, 3 months and 6 months after gavage is examined and detects, as a result mouse normally survives, and anatomical results and master
Want biochemical indicator normal, illustrate that Chinese medicine composition provided by the invention without long term toxicity, adapts to long-term use of.
The pharmacodynamics test of three Chinese medicine composition of the present invention of test example
Take male WISTAR rats 64, body weight 190-210g, be randomly divided into 8 groups, Normal group, one group of embodiment,
Two groups of embodiment, 1 group of comparative example, 2 groups of comparative example, model group, commercially available group.Normal group gavage physiological saline 1ml/d, remaining
7 groups of daily intramuscular injection hydrocortisone 1.5mg/100g, carry out modeling for continuous 2 weeks, and model group gavage while modeling is given birth to
Manage salt solution 1ml/d, 2 groups of one group of embodiment, two groups of embodiment, 1 group of comparative example and comparative example distinguish while modeling gavage to
Medicine phases answer Chinese medicine composition tablet made from embodiment, dosage 10g/kg, and daily gavage 2 times, commercially available group of gastric infusion is commercially available
Guilubushen Tablet, dosage 10g/kg, daily gavage 2 times.Modeling terminates 1 week afterwards, and 1h is fast after last dose for each group rat
Speed takes blood from retroorbital venous clump, determines cortisol, testriol, norepinephrine and adrenergic concentration in serum, knot
Fruit is as shown in table 1.
1 Chinese medicine composition provided by the invention of table is endocrine on rats with deficiency of kidney-Yang to influence result table
As known from Table 1, Chinese medicine composition made from the embodiment of the present invention one and embodiment two is remarkably improved kidney-yang deficiency
Cortisol, testriol, norepinephrine and the Adrenaline Concentration of rat, improve endocrine function, and improvement is slightly better than
Commercially available group.1 group of comparative example is remarkably improved the cortisol, norepinephrine and Adrenaline Concentration of rats with deficiency of kidney-Yang, but carries
High-amplitude is significantly lower than two groups of one group of embodiment and embodiment；2 groups of comparative example is remarkably improved the cortisol of rats with deficiency of kidney-Yang, testis
Ball alcohol, norepinephrine and Adrenaline Concentration, but increase rate is significantly lower than two groups of one group of embodiment and embodiment.
Clinical efficacy for Chinese medicine composition tablet made from the investigation embodiment of the present invention one, comparative example 2 to Patients with Kidney Deficiency Type,
200 patient volunteers's (male 121 people, the people of female 79, the range of age are 28~62 years old) met into group condition are convened, are randomly divided into
4 groups of carry out clinical tests, i.e. one group of embodiment, 1 group of comparative example, comparative example 2 groups and commercially available group (commercially available Guilubushen Tablets), every group
50 people, do not have significant difference in sex, age, symptom, coincident with severity degree of condition etc. between each group.Depending on the journey that is in a bad way
Degree gives 2~4 pieces/times respectively, and 2 times a day, with 1 month for a course for the treatment of, result of the test is as shown in table 2.
Efficacy assessment standard：Will be qi-blood deficiency, deficiency of kidney essence, palpitation, insomnia forgetfulness, night sweat, lassitude in loin and legs, dizziness
The symptoms such as tinnitus are divided into：Without, it is light, in, weigh four grades, corresponding score value is respectively 0,2,4,6 point.Therapeutic index (n)=
[score value before (score value after score value-treatment before treatment) ÷ treatments] × 100%, total effective rate=[(effective number of cases+effective number of cases)/
Total number of cases] × 100%.It is effective：The above-mentioned symptom overwhelming majority disappears in syndrome, n >=70%.
Effectively：Above-mentioned symptom disappears substantially in syndrome, 30%≤n<70%.
It is invalid：Above-mentioned symptom has certain improvement, n in syndrome<30%.
The patient volunteer of table 2 takes the effect of Chinese medicine composition tablet provided by the invention 1 month
| Group | It is effective | Effectively | It is invalid | Total effective rate |
| One group of embodiment | 25 | 22 | 3 | 94% |
| 1 group of comparative example | 14 | 21 | 15 | 70% |
| 2 groups of comparative example | 17 | 19 | 14 | 72% |
| Commercially available group | 20 | 23 | 7 | 86% |
As known from Table 2, Chinese medicine composition tablet made from the embodiment of the present invention one has good therapeutic effect to kidney deficiency,
Total effective rate is up to 94%, is significantly better than commercially available group, 1 group of 2 groups of comparative example and comparative example.
The female patient volunteer (the range of age is 26~43 years old) of 80 No-clay weak interbeds is convened, 2 groups is randomly divided into, is faced
Bed is tested, i.e. embodiment one group and commercially available group (commercially available Guilubushen Tablet), every group of 40 people, in age, symptom, the state of an illness between each group
Order of severity etc. does not have significant difference.2~4 pieces/times are given respectively depending on coincident with severity degree of condition, 2 times a day, with 3
The moon is a course for the treatment of, and result of the test is as shown in table 3.
Efficacy assessment standard：
Recovery from illness：Clinical symptoms disappear substantially, the normal menstrual cycle occur；There is two-phase in basal body temperature；Ovulation prediction is drawn
Silk experiment is in cyclically-varying；B ultrasound detection has graaffian follicle and ovum discharge；It is pregnant after treatment.
It is effective：Clinical symptoms are obviously improved, and the normal menstrual cycle occur；Basal body temperature has 1 cycle in 3 cycles
There is two-phase；It is in cyclically-varying that Ovulation prediction wire drawing experiment has 1 cycle in 3 cycles；B ultrasound detection is even graaffian follicle
But have no rupture ovulation, gradual atrophy.
It is invalid：Clinical symptoms are not improved.
The patient volunteer of table 3 takes the effect of Chinese medicine composition tablet provided by the invention 3 months
| Group | Recovery from illness | It is effective | It is invalid | Total effective rate |
| One group of embodiment | 29 | 7 | 4 | 90% |
| Commercially available group | 24 | 9 | 7 | 82.5% |
As known from Table 3, Chinese medicine composition tablet provided by the invention has significant ovulation rate and improves pregnancy rate
Effect, total effective rate are up to 90%, and cure rate is high, is significantly better than commercially available group.
In summary, there is Chinese medicine composition provided by the invention significant tonifying both YIN and YANG to act on, and kidney deficiency and ovulation are hindered
Hinder with significant therapeutic effect, it is real by the way that barrenwort and prepared rhizome of rehmannia decocting are boiled into the backfill of the rear dregs of a decoction and the adjustment of dosage
Show the reasonable utilization of the dregs of a decoction, reduce cost, and enhance drug effect.
Above content is to combine specific preferred embodiment further description made for the present invention, it is impossible to is assert
The specific implementation of the present invention is confined to these explanations.For general technical staff of the technical field of the invention,
On the premise of not departing from present inventive concept, some simple deduction or replace can also be made, should all be considered as belonging to the present invention's
Protection domain.
Claims (8)
- A kind of 1. Chinese medicine composition with tonifying both YIN and YANG effect, it is characterised in that：It is made up of the raw material of following parts by weight：Tu Silk 120~135, barrenwort 50~80, teasel root 100~120, cynomorium songaricum 120~140, rhizoma cibotii 150~165, spina date seed 100~ 110th, prepared fleece flower root 155~165, honey-fried licorice root 50~55, dried orange peel 50~60, deer horn glue 20~30, prepared rhizome of rehmannia 180~210, tortoise plastron Glue 30~40, the fruit of Cherokee rose 120~135, astragalus root 100~110, Chinese yam 100~120, raspberry 200~220；Its preparation method comprises the following steps：1）Dried orange peel, Chinese yam, honey-fried licorice root, colla carapacis et plastri testudinis and deer horn glue are weighed, is crushed after mixing, obtains traditional Chinese medicine fine powder；2）Semen Cuscutae, teasel root, cynomorium songaricum, rhizoma cibotii, spina date seed, prepared fleece flower root, the fruit of Cherokee rose, astragalus root and raspberry are weighed, after mixing Crush, add water to cook twice, every time 1 ~ 3h, amount of water is 6 ~ 10 times of weight of medicinal material, filtration, decocting liquid merging, obtains first and decocts Liquid；Barrenwort and prepared rhizome of rehmannia are weighed, is crushed after mixing, is added water to cook twice, every time 1 ~ 3h, amount of water is 6 ~ 10 times of weights of medicinal material Amount, filtration, decocting liquid merge, and obtain the second decocting liquid, the dregs of a decoction are standby；Merge first decocting liquid and second decocting liquid, be condensed into Medicinal extract, drying obtain dried cream powder；3）Fine powder is ground into after the dregs of a decoction are dried, adds the traditional Chinese medicine fine powder and the dried cream powder, mixes, is had The Chinese medicine composition of tonifying both YIN and YANG effect.
- 2. the Chinese medicine composition according to claim 1 with tonifying both YIN and YANG effect, it is characterised in that：By following parts by weight Several raw materials are made：Semen Cuscutae 120~130, barrenwort 60~70, teasel root 100~115, cynomorium songaricum 125~130, rhizoma cibotii 155~ 165th, spina date seed 100~110, prepared fleece flower root 155~165, honey-fried licorice root 50~55, dried orange peel 50~55, deer horn glue 20~25, cultivated land Huang 190~210, colla carapacis et plastri testudinis 30~38, the fruit of Cherokee rose 120~135, astragalus root 100~110, Chinese yam 100~110, raspberry 205 ~220.
- 3. the Chinese medicine composition according to claim 2 with tonifying both YIN and YANG effect, it is characterised in that：By following parts by weight Several raw materials are made：Semen Cuscutae 128, barrenwort 66, teasel root 106, cynomorium songaricum 128, rhizoma cibotii 160, spina date seed 106, prepared fleece flower root 160th, honey-fried licorice root 53, dried orange peel 53, deer horn glue 23, prepared rhizome of rehmannia 200, colla carapacis et plastri testudinis 34, the fruit of Cherokee rose 128, astragalus root 106, Chinese yam 106, Raspberry 213.
- 4. the Chinese medicine composition according to any one of claim 1 to 3 with tonifying both YIN and YANG effect, it is characterised in that： The Semen Cuscutae is fries Semen Cuscutae, and the barrenwort is steaming barrenwort, and the teasel root is interrupted to steam, and the cynomorium songaricum is steaming cynomorium songaricum, The rhizoma cibotii is steams rhizoma cibotii, and the spina date seed is Semen Ziziphi Spinosae (parched), and for the dried orange peel to steam dried orange peel, the deer horn glue is to fry deer horn glue, The colla carapacis et plastri testudinis is fries colla carapacis et plastri testudinis, and the fruit of Cherokee rose is steams the fruit of Cherokee rose, and the Chinese yam is stir-baked RHIZOMA DIOSCOREAE, and the raspberry is that basin is covered in steaming Son.
- 5. the Chinese medicine composition according to claim 1 with tonifying both YIN and YANG effect, it is characterised in that：The phase of the medicinal extract It is 1.10 ~ 1.38 to density.
- 6. the Chinese medicine composition according to claim 1 with tonifying both YIN and YANG effect, it is characterised in that：It is described that there are negative and positive And the Chinese medicine composition of benefit effect adds pharmaceutically acceptable auxiliary material, is made into tablet.
- 7. the preparation method of the Chinese medicine composition according to claim 1 with tonifying both YIN and YANG effect, it is characterised in that：Bag Include following steps：1）Dried orange peel, Chinese yam, honey-fried licorice root, colla carapacis et plastri testudinis and deer horn glue are weighed, is crushed after mixing, obtains traditional Chinese medicine fine powder；2）Semen Cuscutae, teasel root, cynomorium songaricum, rhizoma cibotii, spina date seed, prepared fleece flower root, the fruit of Cherokee rose, astragalus root and raspberry are weighed, after mixing Crush, add water to cook twice, every time 1 ~ 3h, amount of water is 6 ~ 10 times of weight of medicinal material, filtration, decocting liquid merging, obtains first and decocts Liquid；Barrenwort and prepared rhizome of rehmannia are weighed, is crushed after mixing, is added water to cook twice, every time 1 ~ 3h, amount of water is 6 ~ 10 times of weights of medicinal material Amount, filtration, decocting liquid merge, and obtain the second decocting liquid, the dregs of a decoction are standby；Merge first decocting liquid and second decocting liquid, be condensed into Medicinal extract, drying obtain dried cream powder；3）The dregs of a decoction are ground into fine powder, add the traditional Chinese medicine fine powder and the dried cream powder, mixes, obtains with tonifying both YIN and YANG The Chinese medicine composition of effect.
- 8. the preparation method of the Chinese medicine composition according to claim 7 with tonifying both YIN and YANG effect, it is characterised in that：Institute The relative density for stating medicinal extract is 1.10 ~ 1.38.
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