CN107375381A - 一种款冬花鲜榨喷雾干燥颗粒饮片的制备工艺 - Google Patents
一种款冬花鲜榨喷雾干燥颗粒饮片的制备工艺 Download PDFInfo
- Publication number
- CN107375381A CN107375381A CN201710739191.7A CN201710739191A CN107375381A CN 107375381 A CN107375381 A CN 107375381A CN 201710739191 A CN201710739191 A CN 201710739191A CN 107375381 A CN107375381 A CN 107375381A
- Authority
- CN
- China
- Prior art keywords
- tussilago
- squeezing
- concoction
- spray
- materical crude
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 241000249864 Tussilago Species 0.000 title claims abstract description 29
- 239000003814 drug Substances 0.000 title claims abstract description 20
- 239000008187 granular material Substances 0.000 title claims abstract description 11
- 238000005516 engineering process Methods 0.000 title claims abstract description 9
- 238000002360 preparation method Methods 0.000 title claims abstract description 8
- 239000000463 material Substances 0.000 claims abstract description 18
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 14
- 238000003756 stirring Methods 0.000 claims abstract description 7
- 235000020985 whole grains Nutrition 0.000 claims abstract description 5
- 238000003306 harvesting Methods 0.000 claims abstract description 3
- 235000011389 fruit/vegetable juice Nutrition 0.000 claims description 9
- 239000012141 concentrate Substances 0.000 claims description 5
- 230000014759 maintenance of location Effects 0.000 claims description 5
- 239000012634 fragment Substances 0.000 claims description 4
- 239000000843 powder Substances 0.000 claims description 4
- 239000011122 softwood Substances 0.000 claims description 4
- 239000007921 spray Substances 0.000 claims description 4
- 238000001035 drying Methods 0.000 claims description 2
- 230000000717 retained effect Effects 0.000 claims description 2
- 238000009461 vacuum packaging Methods 0.000 claims description 2
- 206010013786 Dry skin Diseases 0.000 claims 1
- 239000007788 liquid Substances 0.000 claims 1
- 239000004480 active ingredient Substances 0.000 abstract description 6
- 230000000694 effects Effects 0.000 abstract description 4
- 238000000034 method Methods 0.000 abstract description 4
- 238000001694 spray drying Methods 0.000 abstract description 4
- 238000001914 filtration Methods 0.000 abstract description 3
- 230000009286 beneficial effect Effects 0.000 abstract description 2
- 230000000192 social effect Effects 0.000 abstract description 2
- 238000005469 granulation Methods 0.000 abstract 1
- 230000003179 granulation Effects 0.000 abstract 1
- 238000002386 leaching Methods 0.000 abstract 1
- 238000002156 mixing Methods 0.000 abstract 1
- 239000000047 product Substances 0.000 description 6
- 206010011224 Cough Diseases 0.000 description 5
- 238000000605 extraction Methods 0.000 description 3
- 206010036790 Productive cough Diseases 0.000 description 2
- 239000003963 antioxidant agent Substances 0.000 description 2
- 230000003078 antioxidant effect Effects 0.000 description 2
- 230000006837 decompression Effects 0.000 description 2
- 239000000706 filtrate Substances 0.000 description 2
- 238000000227 grinding Methods 0.000 description 2
- 238000002372 labelling Methods 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 238000004806 packaging method and process Methods 0.000 description 2
- 208000024794 sputum Diseases 0.000 description 2
- 210000003802 sputum Anatomy 0.000 description 2
- 235000008495 Chrysanthemum leucanthemum Nutrition 0.000 description 1
- 244000192528 Chrysanthemum parthenium Species 0.000 description 1
- 235000000604 Chrysanthemum parthenium Nutrition 0.000 description 1
- 208000000059 Dyspnea Diseases 0.000 description 1
- 206010013975 Dyspnoeas Diseases 0.000 description 1
- 241000196324 Embryophyta Species 0.000 description 1
- 208000000616 Hemoptysis Diseases 0.000 description 1
- 235000004869 Tussilago farfara Nutrition 0.000 description 1
- 208000013116 chronic cough Diseases 0.000 description 1
- 230000007423 decrease Effects 0.000 description 1
- 238000005265 energy consumption Methods 0.000 description 1
- 235000008384 feverfew Nutrition 0.000 description 1
- 239000007791 liquid phase Substances 0.000 description 1
- 210000004072 lung Anatomy 0.000 description 1
- 239000012567 medical material Substances 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 238000012856 packing Methods 0.000 description 1
- 238000005453 pelletization Methods 0.000 description 1
- 238000007639 printing Methods 0.000 description 1
- 230000004044 response Effects 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 238000001228 spectrum Methods 0.000 description 1
- 238000003860 storage Methods 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- 230000010415 tropism Effects 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/10—Preparation or pretreatment of starting material
- A61K2236/13—Preparation or pretreatment of starting material involving cleaning, e.g. washing or peeling
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/31—Extraction of the material involving untreated material, e.g. fruit juice or sap obtained from fresh plants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation or decoction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
Landscapes
- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Alternative & Traditional Medicine (AREA)
- Biotechnology (AREA)
- Botany (AREA)
- Medical Informatics (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Medicines Containing Plant Substances (AREA)
- Medicinal Preparation (AREA)
Abstract
本发明公布了一种款冬花鲜榨喷雾干燥颗粒饮片的制备工艺。该工艺在款冬花药材采收后，净选、淋洗，并趁鲜压榨，滤取药汁。药渣再加水搅拌，过滤压榨。所得药汁合并后减压浓缩，喷雾干燥，收集喷干产物，经粉碎与初榨药汁混合制粒，整粒后真空包装。此法制备的款冬花颗粒饮片，最大限度地保留了药材中的极性和非极性有效成分。颗粒饮片流动性好，利于储运，方便调剂，质量可控，疗效可靠，对保障中医药临床疗效具有重要的意义。本法的推广实施，将有显著的社会意义和经济效益。
Description
技术领域
本发明属于中药材加工领域，尤其涉及中药款冬花饮片的加工工艺。
背景技术
中药款冬花为菊科植物款冬Tussilago farfara L.的干燥花蕾。本品具有润肺下气，止咳化痰的功效，主要用于新久咳嗽，喘咳痰多，劳嗽咳血等的治疗。
常用的款冬花饮片的加工方式为：12月或地冻前当花尚未出土时采挖，除去花梗和泥沙，阴干，再打包储运。此类饮片，体积庞大，卫生学指标差，容易污染和霉变，质量很难保证，不利于配方调剂和确保其临床疗效，甚至给患者带来隐性的危害。
目前，市场上也有款冬花药材经过提取后制成的颗粒饮片销售。颗粒饮片的制备过程，提取不仅耗时耗能，而且因常用大量的水做溶媒，药材中的非极性有效成分很难被提取出来。此外，由于提取用的款冬花药材也是干燥并经过长时间储藏的，因此，有效成分的损失也是很大的。为了确保款冬花药材的临床有效、质量稳定，一种新型的款冬花饮片及其制备工艺亟待开发。
发明内容
本发明公布了 “一种款冬花鲜榨喷雾干燥颗粒饮片的制备工艺”。本工艺可以最大限度的保留款冬花药材中的极性和非极性有效成分，避免药材在现有的饮片加工和储运过程中引起的有效成分的丢失和药材品质的下降，减少药材受霉菌等的污染，对确保款冬花饮片的质量稳定和临床安全有效具有重要的意义。
为了实现上述目的，本发明的技术方案为：
在款冬花采收后，切成0.5~0.8mm碎片，加入药材重量0.5~1倍量的水，搅拌15~30分钟，趁鲜压榨，收集初榨药汁，留存0.1%~0.5%重量的初榨药汁备用，药渣加入1~5倍量的水，搅拌5~30min，压榨取汁，所剩药渣再加入1~5倍量的水，压榨取汁，合并初榨药汁及后两次压榨药汁，100~200目筛过滤，得到款冬花药汁。将得到的款冬花药汁于40~75℃条件下减压浓缩至相对密度为1.02~1.15的浓缩液，并将此浓缩液喷雾干燥，进风口温度设定为90~140℃，出风口温度为80~110℃，收集干燥产物，粉碎后过60~100目筛。将上述款冬花喷雾干燥粉，与留存的初榨药汁混合，制备软材，制粒，50~80℃干燥4~8小时，整粒，真空包装。在产品包装袋的标签上，印刷上品名、药用部位、种植地、饮片生产商、生产日期、主要成分含量、性味归经、功能主治、用法用量、毒副作用及禁忌证等信息。袋内附上款冬花的薄层鉴别图谱和/或高效液相特征图谱，作为产品的“身份证”。此外，在产品的包装袋上，印有二维码，通过扫描可以链接获取产品的原植物照片、药材照片、饮片照片、性状及显微鉴别特征等信息。
本发明的有益之处在于：
新鲜采集的款冬花药材，净选洗涤后直接压榨、过滤、减压浓缩、喷雾干燥、制粒，所得到的颗粒饮片，可以最大限度地保留药材中的有效成分。 这种饮片体积较之于传统饮片体积大大地减小，流动性好，真空包装，使得饮片质量更加稳定，利于储运和临床调剂，具有十分显著的社会意义和经济意义。
具体实施方式
实施例1
将新鲜采集的款冬花药材，净选，用水洗去泥沙，切成0.5mm碎片，加入药材重量0.5倍量的水，搅拌15分钟，趁鲜压榨，留存0.1%重量的初榨药汁另用。所得药渣加3倍量的自来水，搅拌20min，板框压滤机压榨取汁。剩下的药渣再用压榨机压榨取汁。将上述剩余的初榨药汁与后续两次压榨药汁合并，用100目筛网过滤。滤液减压浓缩，温度设定为65℃。在浓缩所得浸膏相对密度为1.05时，喷雾干燥，进风口温度为140℃，出风口温度为100℃，收集喷干物，低温粉碎，过80目筛。将此喷雾干燥粉与上述留存的初榨药汁混合制软材，制粒，75℃干燥6小时，整粒，装袋，1kg/袋，加入袋装抗氧剂和干燥剂，真空封装，贴签即可。
实施例2
将新鲜采集的款冬花药材，净选，用水洗去泥沙，切成0.8mm碎片，加入药材重量1倍量的水，搅拌30分钟，趁鲜压榨，留存0.5%重量的初榨药汁另用。所得药渣加5倍量的自来水，搅拌30min，板框压滤机压榨取汁。剩下的药渣再用压榨机压榨取汁。将上述剩余的初榨药汁与后续两次压榨药汁合并，用100目筛网过滤。滤液减压浓缩，温度设定为70℃。在浓缩所得浸膏相对密度为1.10时，喷雾干燥，进风口温度为120℃，出风口温度为90℃，收集喷干物，低温粉碎，过80目筛。将此喷雾干燥粉与上述留存的初榨药汁混合制软材，制粒，70℃干燥8小时，整粒，装袋，1kg/袋，加入袋装抗氧剂和干燥剂，真空封装，贴签即可。
以上实施例，仅为说明本项发明的技术思想，不能凭此限定本发明的保护范围 凡是按照本发明提出的技术思想，在技术方案基础上所做的任何改动，均落入本发明保护的范围之内。
Claims (2)
1.一种款冬花鲜榨喷雾干燥颗粒饮片的制备工艺，其特征在于：在款冬花采收后，切成0.5~0.8mm碎片，加入药材重量0.5~1倍量的水，搅拌15~30分钟，趁鲜压榨，收集初榨药汁，留存0.1%~0.5%重量的初榨药汁备用，药渣加入1~5倍量的水，搅拌5~30min，压榨取汁，所剩药渣再加入1~5倍量的水，压榨取汁，合并初榨药汁及后两次压榨药汁，100~200目筛过滤,得到款冬花药汁。
2.根据权利要求1所述的一种款冬花鲜榨喷雾干燥颗粒饮片的制备工艺，其特征在于：将权利要求1中得到的款冬花药汁于40~75℃条件下减压浓缩至相对密度为1.02~1.15的浓缩液，并将此浓缩液喷雾干燥，进风口温度设定为90~140℃，出风口温度为80~110℃，收集干燥产物，粉碎后过60~100目筛，得到款冬花喷雾干燥粉，将其与权利要求1中留存的初榨药汁混合，制备软材，制粒，50~80℃干燥4~8小时，整粒，真空包装即可。
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710739191.7A CN107375381A (zh) | 2017-08-25 | 2017-08-25 | 一种款冬花鲜榨喷雾干燥颗粒饮片的制备工艺 |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710739191.7A CN107375381A (zh) | 2017-08-25 | 2017-08-25 | 一种款冬花鲜榨喷雾干燥颗粒饮片的制备工艺 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN107375381A true CN107375381A (zh) | 2017-11-24 |
Family
ID=60345995
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201710739191.7A Pending CN107375381A (zh) | 2017-08-25 | 2017-08-25 | 一种款冬花鲜榨喷雾干燥颗粒饮片的制备工艺 |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN107375381A (zh) |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105287858A (zh) * | 2015-11-22 | 2016-02-03 | 徐漫 | 一种泡桐花鲜榨喷雾干燥颗粒饮片及其制备工艺 |
| CN105998151A (zh) * | 2016-07-24 | 2016-10-12 | 徐漫 | 一种地锦草鲜榨喷雾干燥颗粒饮片及其制备工艺 |
| CN105998168A (zh) * | 2016-07-23 | 2016-10-12 | 徐自升 | 一种槐花鲜榨喷雾干燥颗粒饮片及其制备工艺 |
| CN106038491A (zh) * | 2016-07-23 | 2016-10-26 | 徐漫 | 一种马鞭草鲜榨喷雾干燥颗粒饮片及其制备工艺 |
| CN106074686A (zh) * | 2016-07-31 | 2016-11-09 | 徐漫 | 一种冬凌草鲜榨喷雾干燥颗粒饮片及其制备工艺 |
-
2017
- 2017-08-25 CN CN201710739191.7A patent/CN107375381A/zh active Pending
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105287858A (zh) * | 2015-11-22 | 2016-02-03 | 徐漫 | 一种泡桐花鲜榨喷雾干燥颗粒饮片及其制备工艺 |
| CN105998168A (zh) * | 2016-07-23 | 2016-10-12 | 徐自升 | 一种槐花鲜榨喷雾干燥颗粒饮片及其制备工艺 |
| CN106038491A (zh) * | 2016-07-23 | 2016-10-26 | 徐漫 | 一种马鞭草鲜榨喷雾干燥颗粒饮片及其制备工艺 |
| CN105998151A (zh) * | 2016-07-24 | 2016-10-12 | 徐漫 | 一种地锦草鲜榨喷雾干燥颗粒饮片及其制备工艺 |
| CN106074686A (zh) * | 2016-07-31 | 2016-11-09 | 徐漫 | 一种冬凌草鲜榨喷雾干燥颗粒饮片及其制备工艺 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN105213660A (zh) | 一种芦荟鲜榨喷雾干燥颗粒饮片及其制备工艺 | |
| CN107281247A (zh) | 一种墨旱莲鲜榨喷雾干燥颗粒饮片的制备工艺 | |
| CN107281236A (zh) | 一种苦丁茶鲜榨喷雾干燥颗粒饮片及其制备工艺 | |
| CN107320508A (zh) | 一种凌霄花鲜榨喷雾干燥颗粒饮片的制备工艺 | |
| CN107468751A (zh) | 一种连钱草鲜榨喷雾干燥颗粒饮片的制备工艺 | |
| CN107441223A (zh) | 一种鱼腥草鲜榨喷雾干燥颗粒饮片的制备工艺 | |
| CN107028997A (zh) | 一种小蓟鲜榨喷雾干燥粉末饮片及其制备工艺 | |
| CN107233384A (zh) | 一种益母草鲜榨喷雾干燥颗粒饮片及其制备工艺 | |
| CN107375381A (zh) | 一种款冬花鲜榨喷雾干燥颗粒饮片的制备工艺 | |
| CN107375364A (zh) | 一种金钱草鲜榨喷雾干燥颗粒饮片的制备工艺 | |
| CN107375389A (zh) | 一种茵陈鲜榨喷雾干燥颗粒饮片的制备工艺 | |
| CN107375529A (zh) | 一种白英鲜榨喷雾干燥颗粒饮片的制备工艺 | |
| CN107157939A (zh) | 一种辛夷花鲜榨冷冻干燥粉末饮片及其制备工艺 | |
| CN107485633A (zh) | 一种艾叶鲜榨喷雾干燥粉末饮片的制备工艺 | |
| CN107397787A (zh) | 一种广藿香鲜榨喷雾干燥颗粒饮片的制备工艺 | |
| CN107334833A (zh) | 一种枇杷叶鲜榨喷雾干燥颗粒饮片的制备工艺 | |
| CN106109597A (zh) | 一种车前草鲜榨喷雾干燥颗粒饮片及其制备工艺 | |
| CN107375433A (zh) | 一种桑叶鲜榨喷雾干燥颗粒饮片的制备工艺 | |
| CN107375417A (zh) | 一种泽兰鲜榨喷雾干燥颗粒饮片的制备工艺 | |
| CN107334790A (zh) | 一种凤尾草鲜榨喷雾干燥颗粒饮片的制备工艺 | |
| CN107334796A (zh) | 一种矮地茶鲜榨喷雾干燥颗粒饮片的制备工艺 | |
| CN107485639A (zh) | 一种透骨草鲜榨喷雾干燥颗粒饮片的制备工艺 | |
| CN107375349A (zh) | 一种木贼鲜榨喷雾干燥颗粒饮片的制备工艺 | |
| CN107233377A (zh) | 一种小蓟鲜榨喷雾干燥颗粒饮片及其制备工艺 | |
| CN107375379A (zh) | 一种大丁草鲜榨喷雾干燥颗粒饮片的制备工艺 |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| WD01 | Invention patent application deemed withdrawn after publication | ||
| WD01 | Invention patent application deemed withdrawn after publication |
Application publication date: 20171124 |