CN107281015A - The anti-aging whitening topical agent and preparation method of a kind of Cistanche tubulosa extract - Google Patents
The anti-aging whitening topical agent and preparation method of a kind of Cistanche tubulosa extract Download PDFInfo
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- CN107281015A CN107281015A CN201610215790.4A CN201610215790A CN107281015A CN 107281015 A CN107281015 A CN 107281015A CN 201610215790 A CN201610215790 A CN 201610215790A CN 107281015 A CN107281015 A CN 107281015A
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- cistanche tubulosa
- extract
- tubulosa extract
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/02—Preparations for care of the skin for chemically bleaching or whitening the skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
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- Gerontology & Geriatric Medicine (AREA)
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Abstract
The invention discloses a kind of anti-aging whitening topical agent of Cistanche tubulosa extract, including Cistanche tubulosa extract, fatty alcohol, mineral oil, phosphatide, water-soluble polymer, surfactant, mineral matter and deionized water, the Cistanche tubulosa extract, fatty alcohol, mineral oil, phosphatide, water-soluble polymer, surfactant, mineral matter and deionized water are 1 according to mass ratio:5:2:1:30:10:1：1000 mix.The technical scheme is during Cistanche tubulosa extract is prepared, only by centrifugation, physical filtering and the standing several processes of crystallization, whole extraction process is simple and easy to operate, reduce production cost, and the content of active component still reaches higher level in extract, it is higher than or equivalent to the recovery rate for the other extracting methods once reported, it was demonstrated that the characteristics of extraction process of present disclosure has simple and effective.
Description
Technical field
The present invention relates to Cistanche tubulosa processing technology field, the anti-aging whitening topical agent and preparation method of specially a kind of Cistanche tubulosa extract.
Background technology
It is increasingly serious with world population ages, many diseases such as senile dementia relevant with aging etc. seriously threatens the healthy factor of the elderly as today's society, because curative mechanism is complicated, the medicine with significant curative effect for the disease is not yet found at present.Clinic is used for as traditional kidney tonifying, establishing-Yang, strong smart medicine based on Cistanche tubulosa for a long time, therefore as the object furtherd investigate.
Chinese medicine Cistanche tubulosa is the perennial parasitic herbaceous plant of Orobanchaceae Cistanche deserticola, the Takla Makan Desert and its surrounding area of the main product in Xinjiang, China South Sinkiang, parasitize on each of Tamarix, its medicinal fleshy stem, with kidney-replenishing, benefiting essence-blood, relax bowel the effect of, the diseases such as impotence in male, female sterility, blood depletion constipation are cured mainly, there is the good reputation of desert ginseng.Cistanche tubulosa is one kind of yield maximum in Cistanche deserticola.
So far, the domestic report about Cistanche tubulosa, it is concentrated mainly on plantation yield, on health food and medical applications, also once had been reported that the phenylethanoid glycoside in Cistanche tubulosa extract was inhibited to tyrosinase, the extract containing tool white-skinned face function in Cistanche tubulosa is also reveal that in Chinese patent 200610117216.1, but does not carry out efficacy validation, simple and effective extracting method is not disclosed yet.
The content of the invention
It is an object of the invention to provide it is a kind of it is simple, efficiently, environmental protection based on Cistanche tubulosa extract preparation method, and Cistanche tubulosa extract will be prepared applied in whitening anti-aging cosmetics, to solve the problems mentioned in the above background technology.
To achieve the above object, the present invention provides following technical scheme：A kind of anti-aging whitening topical agent of Cistanche tubulosa extract, including Cistanche tubulosa extract, fatty alcohol, mineral oil, phosphatide, water-soluble polymer, surfactant, mineral matter and deionized water, Cistanche tubulosa extract, fatty alcohol, mineral oil, phosphatide, water-soluble polymer, surfactant, mineral matter and deionized water are 1 according to mass ratio:5:2:1:30:10:1：1000 mix.
The preparation method of the anti-aging whitening topical agent of the Cistanche tubulosa extract, comprises the following steps：
A. the preparation of Cistanche tubulosa extract；
B. 30%~70% water-soluble polymer will be added in step a Cistanche tubulosa extract to boil, Cistanche tubulosa extract is 1 with water-soluble polymer mass volume ratio:6~1:18g/ml, is extracted 4~5 hours at a temperature of 50 DEG C~90 DEG C, repeats to extract three times；
C. step b crude extract is centrifuged into 0.6h in centrifuge by 2500rpm of rotating speed, collects supernatant, be concentrated under reduced pressure into 1/2 to 1/4 of extracting liquid volume in step b；
D. fatty alcohol, mineral oil, phosphatide, surfactant and mineral matter are added in the concentrate obtained by step c, then it is 1.5%~2.5% to adjust to Cistanche tubulosa extract concentration, and 24~48 hours are stood under 4 DEG C of environment；
E. concentrate step d obtained centrifuges 1h in centrifuge with rotating speed 3000rpm, collects supernatant, is concentrated into behind the 1/10~1/20 of the volume of concentrate obtained in step d and is sufficiently mixed with deionized water.
It is preferred that, the preparation of Cistanche tubulosa extract comprises the following steps：
1）The fleshy stem of Cistanche tubulosa is taken, is crushed, then adds Aqua pure extract 1~3 time, then separation of solid and liquid, obtains clear liquid and residue；
2) use aperture for 0.25 μm of micro-filtrate membrane filtration clear liquid, obtain permeate A；
3）Using spiral wound ultrafiltration membrance filter permeate A, permeate B and the trapped fluid A containing polyose are obtained；
4）Using spiral wound nanofiltration membrane permeate B, the trapped fluid B containing oligomeric sugar product and the permeate C containing mannitol product are obtained;
5）Obtained permeate C is concentrated under reduced pressure, crystallization 2~5 days are stood under 5 DEG C of environment, after crystallization completely, separation of solid and liquid prepares crude product Cistanche tubulosa extract, and Cistanche tubulosa extract is made in recrystallization.
Compared with prior art, the beneficial effects of the invention are as follows：The technical scheme is during Cistanche tubulosa extract is prepared, only by centrifugation, physical filtering and the standing several processes of crystallization, whole extraction process is simple and easy to operate, reduce production cost, and the content of active component still reaches higher level in extract, it is higher than or equivalent to the recovery rate for the other extracting methods once reported, it was demonstrated that the characteristics of extraction process of present disclosure has simple and effective.
Embodiment
The technical scheme in the embodiment of the present invention is clearly and completely described below, it is clear that described embodiment is only a part of embodiment of the invention, rather than whole embodiments.Based on the embodiment in the present invention, the every other embodiment that those of ordinary skill in the art are obtained under the premise of creative work is not made belongs to the scope of protection of the invention.
The present invention provides a kind of technical scheme：A kind of anti-aging whitening topical agent of Cistanche tubulosa extract, including Cistanche tubulosa extract, fatty alcohol, mineral oil, phosphatide, water-soluble polymer, surfactant, mineral matter and deionized water, Cistanche tubulosa extract, fatty alcohol, mineral oil, phosphatide, water-soluble polymer, surfactant, mineral matter and deionized water are 1 according to mass ratio:5:2:1:30:10:1：1000 mix.
The preparation method of the anti-aging whitening topical agent of the Cistanche tubulosa extract, comprises the following steps：
A. the preparation of Cistanche tubulosa extract；
B. 30%~70% water-soluble polymer will be added in step a Cistanche tubulosa extract to boil, Cistanche tubulosa extract is 1 with water-soluble polymer mass volume ratio:6~1:18g/ml, is extracted 4~5 hours at a temperature of 50 DEG C~90 DEG C, repeats to extract three times；
C. step b crude extract is centrifuged into 0.6h in centrifuge by 2500rpm of rotating speed, collects supernatant, be concentrated under reduced pressure into 1/2 to 1/4 of extracting liquid volume in step b；
D. fatty alcohol, mineral oil, phosphatide, surfactant and mineral matter are added in the concentrate obtained by step c, then it is 1.5%~2.5% to adjust to Cistanche tubulosa extract concentration, and 24~48 hours are stood under 4 DEG C of environment；
E. concentrate step d obtained centrifuges 1h in centrifuge with rotating speed 3000rpm, collects supernatant, is concentrated into behind the 1/10~1/20 of the volume of concentrate obtained in step d and is sufficiently mixed with deionized water.
The preparation of wherein Cistanche tubulosa extract comprises the following steps：
1）The fleshy stem of Cistanche tubulosa is taken, is crushed, then adds Aqua pure extract 1~3 time, then separation of solid and liquid, obtains clear liquid and residue；
2) use aperture for 0.25 μm of micro-filtrate membrane filtration clear liquid, obtain permeate A；
3）Using spiral wound ultrafiltration membrance filter permeate A, permeate B and the trapped fluid A containing polyose are obtained；
4）Using spiral wound nanofiltration membrane permeate B, the trapped fluid B containing oligomeric sugar product and the permeate C containing mannitol product are obtained;
5）Obtained permeate C is concentrated under reduced pressure, crystallization 2~5 days are stood under 5 DEG C of environment, after crystallization completely, separation of solid and liquid prepares crude product Cistanche tubulosa extract, and Cistanche tubulosa extract is made in recrystallization.
Compared with prior art, the technical scheme is during Cistanche tubulosa extract is prepared, only by centrifugation, physical filtering and the standing several processes of crystallization, whole extraction process is simple and easy to operate, reduce production cost, and the content of active component still reaches higher level in extract, it is higher than or equivalent to the recovery rate for the other extracting methods once reported, it was demonstrated that the characteristics of extraction process of present disclosure has simple and effective.
Although an embodiment of the present invention has been shown and described, for the ordinary skill in the art, it is appreciated that a variety of change, modification, replacement and modification can be carried out to these embodiments without departing from the principles and spirit of the present invention, the scope of the present invention is defined by the appended.
Claims (3)
1. a kind of anti-aging whitening topical agent of Cistanche tubulosa extract, it is characterised in that：Including Cistanche tubulosa extract, fatty alcohol, mineral oil, phosphatide, water-soluble polymer, surfactant, mineral matter and deionized water, the Cistanche tubulosa extract, fatty alcohol, mineral oil, phosphatide, water-soluble polymer, surfactant, mineral matter and deionized water are 1 according to mass ratio:5:2:1:30:10:1：1000 mix.
2. a kind of a kind of preparation method of the anti-aging whitening topical agent for the Cistanche tubulosa extract realized described in claim 1, it is characterised in that：Comprise the following steps：
A. the preparation of Cistanche tubulosa extract；
B. 30%~70% water-soluble polymer will be added in step a Cistanche tubulosa extract to boil, Cistanche tubulosa extract is 1 with water-soluble polymer mass volume ratio:6~1:18g/ml, is extracted 4~5 hours at a temperature of 50 DEG C~90 DEG C, repeats to extract three times；
C. step b crude extract is centrifuged into 0.6h in centrifuge by 2500rpm of rotating speed, collects supernatant, be concentrated under reduced pressure into 1/2 to 1/4 of extracting liquid volume in step b；
D. fatty alcohol, mineral oil, phosphatide, surfactant and mineral matter are added in the concentrate obtained by step c, then it is 1.5%~2.5% to adjust to Cistanche tubulosa extract concentration, and 24~48 hours are stood under 4 DEG C of environment；
E. concentrate step d obtained is in centrifuge with rotating speed 3000rpm
1h is centrifuged, supernatant is collected, is concentrated into behind the 1/10~1/20 of the volume of concentrate obtained in step d and is sufficiently mixed with deionized water.
3. a kind of preparation method of the anti-aging whitening topical agent of Cistanche tubulosa extract according to claim 2, it is characterised in that：The preparation of the Cistanche tubulosa extract comprises the following steps：
1）The fleshy stem of Cistanche tubulosa is taken, is crushed, then adds Aqua pure extract 1~3 time, then separation of solid and liquid, obtains clear liquid and residue；
2) use aperture for 0.25 μm of micro-filtrate membrane filtration clear liquid, obtain permeate A；
3）Using spiral wound ultrafiltration membrance filter permeate A, permeate B and the trapped fluid A containing polyose are obtained；
4）Using spiral wound nanofiltration membrane permeate B, the trapped fluid B containing oligomeric sugar product and the permeate C containing mannitol product are obtained;
5）Obtained permeate C is concentrated under reduced pressure, crystallization 2~5 days are stood under 5 DEG C of environment, after crystallization completely, separation of solid and liquid prepares crude product Cistanche tubulosa extract, and Cistanche tubulosa extract is made in recrystallization.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610215790.4A CN107281015A (en) | 2016-04-09 | 2016-04-09 | The anti-aging whitening topical agent and preparation method of a kind of Cistanche tubulosa extract |
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| CN201610215790.4A CN107281015A (en) | 2016-04-09 | 2016-04-09 | The anti-aging whitening topical agent and preparation method of a kind of Cistanche tubulosa extract |
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| CN201610215790.4A Pending CN107281015A (en) | 2016-04-09 | 2016-04-09 | The anti-aging whitening topical agent and preparation method of a kind of Cistanche tubulosa extract |
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Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1943545A (en) * | 2006-10-17 | 2007-04-11 | 王海龙 | Cosmetics composite and its preparing method and use |
| CN102670436A (en) * | 2012-03-13 | 2012-09-19 | 珈侬生化科技(中国)有限公司 | Skin-whitening anti-aging cosmetic containing Cistanche tubulosa extract and its preparation method |
| CN104926954A (en) * | 2015-06-19 | 2015-09-23 | 中国科学院过程工程研究所 | Method for separating and preparing polysaccharide, oligosaccharide and mannitol from cistanche |
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2016
- 2016-04-09 CN CN201610215790.4A patent/CN107281015A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1943545A (en) * | 2006-10-17 | 2007-04-11 | 王海龙 | Cosmetics composite and its preparing method and use |
| CN102670436A (en) * | 2012-03-13 | 2012-09-19 | 珈侬生化科技(中国)有限公司 | Skin-whitening anti-aging cosmetic containing Cistanche tubulosa extract and its preparation method |
| CN104926954A (en) * | 2015-06-19 | 2015-09-23 | 中国科学院过程工程研究所 | Method for separating and preparing polysaccharide, oligosaccharide and mannitol from cistanche |
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Application publication date: 20171024 |