CN107236057A - 一种获得达肝素钠的降解方法 - Google Patents
一种获得达肝素钠的降解方法 Download PDFInfo
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- CN107236057A CN107236057A CN201710356409.0A CN201710356409A CN107236057A CN 107236057 A CN107236057 A CN 107236057A CN 201710356409 A CN201710356409 A CN 201710356409A CN 107236057 A CN107236057 A CN 107236057A
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- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
- C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
- C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
- C08B37/0075—Heparin; Heparan sulfate; Derivatives thereof, e.g. heparosan; Purification or extraction methods thereof
- C08B37/0078—Degradation products
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- Chemical Kinetics & Catalysis (AREA)
- Medicinal Chemistry (AREA)
- Polymers & Plastics (AREA)
- Organic Chemistry (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
Abstract
Description
分子量 | ﹤3000 | 3000~8000 | ﹥8000 | |
肝素钠 | 16000~18000 | —— | —— | 接近100% |
使用1.4%(m/m)亚硝酸钠降解 | 7493 | 14.3% | 49.6% | 36% |
使用1.8%(m/m)亚硝酸钠降解 | 5500 | 25% | 53% | 22% |
药典规定 | 5600-6400 | ﹤13% | —— | 15~25% |
合理的产品 | 6050 | 11.5% | 66.5% | 22% |
分子量 | ﹤3000 | 3000~8000 | ﹥8000 |
6112 | 10.7% | 65.9% | 23.4% |
分子量 | ﹤3000 | 3000~8000 | ﹥8000 |
6010 | 11.8% | 66.4% | 21.8% |
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CN107236057A true CN107236057A (zh) | 2017-10-10 |
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Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2019159092A1 (en) | 2018-02-14 | 2019-08-22 | Biological E Limited | Improved process for the preparation of dalteparin sodium |
CN112005110A (zh) * | 2018-07-24 | 2020-11-27 | 深圳市海普瑞药业集团股份有限公司 | 一种达肝素钠亚硝酸降解产物的分析方法及其应用 |
CN112175109A (zh) * | 2020-11-05 | 2021-01-05 | 山东万邦赛诺康生化制药股份有限公司 | 一种超低分子量肝素钠及其制备方法 |
CN113024689A (zh) * | 2021-05-21 | 2021-06-25 | 江西浩然生物制药有限公司 | 一种达肝素钠分子量的控制方法 |
Citations (6)
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CN102558393A (zh) * | 2011-12-31 | 2012-07-11 | 河北常山生化药业股份有限公司 | 一种达肝素钠制备工艺 |
CN103232558A (zh) * | 2013-05-02 | 2013-08-07 | 山东辰中生物制药有限公司 | 一种高品质低分子达特安瑞的制备方法 |
CN104086673A (zh) * | 2014-07-28 | 2014-10-08 | 常州千红生化制药股份有限公司 | 一种那屈肝素钙的制备工艺 |
CN104098716A (zh) * | 2014-07-16 | 2014-10-15 | 南京健友生化制药股份有限公司 | 一种达肝素钠精品的生产方法 |
CN105440160A (zh) * | 2015-12-06 | 2016-03-30 | 青岛九龙生物医药有限公司 | 一种达肝素钠的制备方法 |
CN105884934A (zh) * | 2014-10-17 | 2016-08-24 | 北京海吉星医疗科技有限公司 | 一种达肝素钠的制备方法 |
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2017
- 2017-05-19 CN CN201710356409.0A patent/CN107236057B/zh active Active
Patent Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN102558393A (zh) * | 2011-12-31 | 2012-07-11 | 河北常山生化药业股份有限公司 | 一种达肝素钠制备工艺 |
CN103232558A (zh) * | 2013-05-02 | 2013-08-07 | 山东辰中生物制药有限公司 | 一种高品质低分子达特安瑞的制备方法 |
CN104098716A (zh) * | 2014-07-16 | 2014-10-15 | 南京健友生化制药股份有限公司 | 一种达肝素钠精品的生产方法 |
CN104086673A (zh) * | 2014-07-28 | 2014-10-08 | 常州千红生化制药股份有限公司 | 一种那屈肝素钙的制备工艺 |
CN105884934A (zh) * | 2014-10-17 | 2016-08-24 | 北京海吉星医疗科技有限公司 | 一种达肝素钠的制备方法 |
CN105440160A (zh) * | 2015-12-06 | 2016-03-30 | 青岛九龙生物医药有限公司 | 一种达肝素钠的制备方法 |
Cited By (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2019159092A1 (en) | 2018-02-14 | 2019-08-22 | Biological E Limited | Improved process for the preparation of dalteparin sodium |
US11492421B2 (en) | 2018-02-14 | 2022-11-08 | Biological E Limited | Process for the preparation of Dalteparin sodium |
CN112005110A (zh) * | 2018-07-24 | 2020-11-27 | 深圳市海普瑞药业集团股份有限公司 | 一种达肝素钠亚硝酸降解产物的分析方法及其应用 |
CN112005110B (zh) * | 2018-07-24 | 2022-11-29 | 深圳市海普瑞药业集团股份有限公司 | 一种达肝素钠亚硝酸降解产物的分析方法及其应用 |
CN112175109A (zh) * | 2020-11-05 | 2021-01-05 | 山东万邦赛诺康生化制药股份有限公司 | 一种超低分子量肝素钠及其制备方法 |
CN112175109B (zh) * | 2020-11-05 | 2022-07-29 | 山东万邦赛诺康生化制药股份有限公司 | 一种超低分子量肝素钠及其制备方法 |
CN113024689A (zh) * | 2021-05-21 | 2021-06-25 | 江西浩然生物制药有限公司 | 一种达肝素钠分子量的控制方法 |
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