CN107213225A - A kind of pharmaceutical composition and its application for being used to relieving pain, promoting bone uptake - Google Patents

A kind of pharmaceutical composition and its application for being used to relieving pain, promoting bone uptake Download PDF

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Publication number
CN107213225A
CN107213225A CN201710349521.1A CN201710349521A CN107213225A CN 107213225 A CN107213225 A CN 107213225A CN 201710349521 A CN201710349521 A CN 201710349521A CN 107213225 A CN107213225 A CN 107213225A
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parts
pharmaceutical composition
composition according
radix aconiti
pain
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杨宇
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杨宇
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/73Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
    • A61K36/736Prunus, e.g. plum, cherry, peach, apricot or almond
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/12Ketones
    • A61K31/122Ketones having the oxygen directly attached to a ring, e.g. quinones, vitamin K1, anthralin
    • A61K31/125Camphor; Nuclear substituted derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/56Materials from animals other than mammals
    • A61K35/62Leeches; Worms, e.g. cestodes, tapeworms, nematodes, roundworms, earth worms, ascarids, filarias, hookworms, trichinella or taenia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/13Coniferophyta (gymnosperms)
    • A61K36/15Pinaceae (Pine family), e.g. pine or cedar
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/17Gnetophyta, e.g. Ephedraceae (Mormon-tea family)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/21Amaranthaceae (Amaranth family), e.g. pigweed, rockwort or globe amaranth
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/26Aristolochiaceae (Birthwort family), e.g. heartleaf
    • A61K36/264Aristolochia (Dutchman's pipe)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/28Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A61K36/282Artemisia, e.g. wormwood or sagebrush
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/28Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A61K36/286Carthamus (distaff thistle)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/32Burseraceae (Frankincense family)
    • A61K36/324Boswellia, e.g. frankincense
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/32Burseraceae (Frankincense family)
    • A61K36/328Commiphora, e.g. mecca myrrh or balm of Gilead
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/47Euphorbiaceae (Spurge family), e.g. Ricinus (castorbean)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/54Lauraceae (Laurel family), e.g. cinnamon or sassafras
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/56Loganiaceae (Logania family), e.g. trumpetflower or pinkroot
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/57Magnoliaceae (Magnolia family)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/60Moraceae (Mulberry family), e.g. breadfruit or fig
    • A61K36/605Morus (mulberry)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/70Polygonaceae (Buckwheat family), e.g. spineflower or dock
    • A61K36/708Rheum (rhubarb)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/71Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
    • A61K36/714Aconitum (monkshood)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/73Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
    • A61K36/732Chaenomeles, e.g. flowering quince

Abstract

The invention discloses a kind of pharmaceutical composition for being used to relieving pain, promoting bone uptake, the active component of described pharmaceutical composition is prepared from by the raw material including following components:Chinese ephedra, rheum officinale, post slave, Radix Aconiti, Radix Aconiti Kusnezoffii, turpentine, pawpaw, cassia twig, ramulus mori, the root of bidentate achyranthes, anisetree bark, peach kernel, safflower, earthworm, Semen Strychni, frankincense, myrrh, berba aristolochiae mollissimae, lopseed, camphor, rosin, minium.The externally applied ointment that the present invention is provided has promoting blood circulation to remove blood stasis, swelling and pain relieving, the effect of dispelling wind and eliminating dampness, union can be promoted, it is notable to the equal effect of the bone diseases such as disc herniation, osteoporosis, arthralgia, rheumatalgia, bruise, may be made directly to painful area, can effectively pain of alleviation, instant effect, efficacy time it is long.

Description

A kind of pharmaceutical composition and its application for being used to relieving pain, promoting bone uptake
Technical field
The present invention relates to a kind of Chinese medicine composition, and in particular to a kind of pharmaceutical composition for being used to relieving pain, promoting bone uptake.
Background technology
Chinese traditional treatment traumatic injury has the history of thousands of years, and ancient " traumatic injury " is called the introduction of all wounds, more because of external force Effect, or overexert and cause in the case of itself fault.The traditional Chinese medical science causes all because external force acts on human body Muscles and bones hurt, blood stasis and swelling pain, derangement of Qi and blood, blockage of main and collateral channels so that internal organs are impaired etc., be referred to as traumatic injury.
Arthralgia causes mainly due to arthritis or arthropathy.Arthralgia involves scope widely and species It is various, therefore the antidiastole of arthralgia is most important.Arthralgia belongs to the arthrodynia of extremeties, oncotic arthralgia of limbs, numbness in disease of tcm The illness category such as card, gout.
At present, although be mainly used in treating the medicine of traumatic injury and arthralgia has certain effect, but they Content of dispersion is low, and curative effect is single, and treatment cycle is long, so being extremely difficult to preferable therapeutic effect.
In view of this, it is special to propose the present invention.
The content of the invention
The first object of the present invention is to provide a kind of pharmaceutical composition, can be used in treatment traumatic injury, arthralgia, Fracture such as swells and ache at the disease, its Small side effects, instant effect, to analgesic, promote bone uptake to have preferably to act on.
To reach above-mentioned purpose, the present invention is adopted the following technical scheme that:
A kind of pharmaceutical composition, by weight, its active component are prepared from by the raw material including following components:Chinese ephedra 3-15 parts, 3-15 parts of rheum officinale, post 8-20 parts of slave, 8-20 parts of Radix Aconiti, 8-20 parts of Radix Aconiti Kusnezoffii, 8-20 parts of turpentine, 6-15 parts of pawpaw, 3-15 parts of cassia twig, 6-15 parts of ramulus mori, 6-15 parts of the root of bidentate achyranthes, 6-15 parts of anisetree bark, 3-15 parts of peach kernel, 3-15 parts of safflower, earthworm 3-15 Part, 8-20 parts of Semen Strychni, 8-20 parts of frankincense, 8-20 parts of myrrh, 8-20 parts of berba aristolochiae mollissimae, 8-20 parts of lopseed and camphor 8-20 Part.
The present invention is combined on the basis of a large amount of pharmacodynamic experiments by the different compatibilities to a variety of related drugs, is obtained The scientific composition of the present invention.
The raw material for the medicine that the present invention is used is described as follows:
(1) Chinese ephedra:This product is the drying herbaceous stem stem of Ephedraceae plant ephedra sinica, epheday intermedia or ephedra equisetina.It is pungent, micro- Hardship, it is warm-natured;Return lung, bladder warp;It is uncomfortable in chest to breath with cough for anemofrigid cold, geomantic omen edema.
(2) rheum officinale:This product is the dry root and rhizome of polygonum rheum palmatum, Rheum tanguticum Maxim or Rheum officinale.Taste It is bitter, cold in nature;Returns spleen, stomach, large intestine, liver, pericardium channel;Rheum officinale removing pattogenic heat from the blood and toxic material from the body, dispelling stasis of blood and stimulating the menstrual flow, control stagnant stomachache, blood stasis closed, bruise Damage, scald.
(3) slave is posted:This product is the herb of feverfew artemisia anomalas.It is bitter, warm-natured;Enter the heart, the spleen channel;With blood-breaking dysmenorrhoea, hold back The work(of detumescence is created, the disease swollen for Amenorrhea abdominal mass, chest and abdomen swelling and pain, postpartum blood stasis, traumatic injury, metal-inflicted wound bleeding, Yong Du inflammation.Except disease Dissipate-swelling.Metal-inflicted wound hemostasis pole effect.
(4) Radix Aconiti:This product dries female root for the ranunculaceae plant rhizome of Chinese monkshood.Pungent, hardship, property heat;The thoughts of returning home, liver,kidney,spleen Through;For wind-cold-dampness arthralgia, arthralgia, trusted subordinate's crymodynia, cold hernia is had a pain and narcotic analgesic.
(5) Radix Aconiti Kusnezoffii:This product is the dried root of the northern rhizome of Chinese monkshood of ranunculaceae plant.Pungent, hardship, property heat;The thoughts of returning home, liver, kidney, The spleen channel;For wind-cold-dampness arthralgia, arthralgia, trusted subordinate's crymodynia, cold hernia is had a pain and narcotic analgesic.
(6) turpentine:This product is the tubercle of the limbs such as pinaceae plant Chinese pine, masson pine, Japanese red pine, pinus yunnanensis.Bitter, it is warm-natured; Return liver and kidney channel;There are certain analgesic and anti-inflammatory effects;Main wind-cold-dampness arthralgia, severe and wadering arthralgia pain;Pin numbness impotence is soft, injuries from falls as well.
(7) pawpaw:This product is the drying almost ripe fruit of rosaceous plant chaenomeles lagenaria.It is sour, warm-natured;Return liver, spleen Through;Stimulate the circulation of the blood and cause the muscles and joints to relax, stomach dampness elimination, for arthritis with fixed pain caused by dampness contraction, waist and knee joint acid weight pain, summer-heat and damp is vomited and diarrhoea, convulsion contraction pain, beriberi liquor It is swollen.
(8) cassia twig:This product is the dry twig of canella Chinese cassia tree.It is pungent, sweet, it is warm-natured;The thoughts of returning home, lung, bladder warp;Hair Sweat expelling pathogenic factors from muscles and skin, warming meridian, helps yang transforming qi, flat gas that spins.For anemofrigid cold, coldness and pain in the epigastrium, blood trembles with fear Amenorrhea, joint pain.
(9) ramulus mori:This product is the dry twig of moraceae plants mulberry.Mildly bitter flavor, it is mild-natured;Return liver warp;Wind-damp dispelling, sharp joint. For Bi condition, shoulder arm, joint pain are numb.
(10) root of bidentate achyranthes:This product is the dry root of the amaranthaceous plant root of bidentate achyranthes.Sweet, slight bitter, it is mild-natured;Return liver and kidney channel;By stasis caused pain Through easing joint movement, inducing diuresis for treating strangurtia.For Jing Bi Disorder lumps in the abdomen, placenta retension, injury from falling down, arthralgia pain due to rheumatism, sufficient impotence muscle contraction.
(11) anisetree bark:This product is the dry bark of Magnoliacea plant anisetree bark.Taste micro-pungent, puckery, row temperature;It is slightly poisonous; Return bladder, kidney channel;Dispelling wind and eliminating dampness, promoting qi circulation and relieving pain;For arthralgia pain due to rheumatism, internal lesion caused by overexertion pain in the back.
(12) peach kernel:This product is the dry mature seed of rosaceous plant peach or mountain peach.It is bitter, sweet, it is mild-natured;The thoughts of returning home, Liver, large intestine channel;With promoting blood circulation and removing blood stasis, relax bowel, the effect of relieving cough and asthma.For closed dysmenorrhea, lump in the abdomen lump in the abdomen lump in the abdomen, lung carbuncle intestines Carbuncle, injury from falling down, dry constipation of intestines, cough and asthma.
(13) safflower:This product dries flower for feverfew safflower.It is pungent, it is warm-natured;The thoughts of returning home, Liver Channel;It is logical with promoting blood circulation The effect of through, blood stasis removing analgesic, for injury from falling down, sore swell and ache curative curative effect.Have promoting blood circulation and removing blood stasis, effect of dissipate wet effect going to swell.
(14) earthworm:This product for Ju Yin sections animal Pheretima aspergillum, popular Pheretimatschiliensis, power simulation or comb blind ring hair The hirudo leech of earthworm.Taste is salty, cold in nature;Return liver, spleen, bladder warp;For unconsciousness due to high fever, twitch, joint pain, extremity numbness.
(15) Semen Strychni:This product is the dry mature seed of loganiaceae plant Strychnos nux-vomica.Bitter, it is warm-natured;Return liver, spleen Through;It is very toxic;Remove obstruction in channels to relieve pain, the effect of mass dissipating and swelling eliminating;For traumatic injury, fracture swells and ache, rheumatoid arthritis stubborn, paralysis and numbness.
(16) frankincense:This product is the resin that olive subject plant Boswellia carterii and congener bark ooze out.Pungent, hardship, property Temperature;The thoughts of returning home, liver, the spleen channel;With promoting blood circulation analgesic therapy, the effect of detumescence and promoting granulation;For arthralgia pain due to rheumatism, tendon and vessel spasm, traumatic injury.
(17) myrrh:This product is olive subject plant Chinese violet tree or Ha Didingshu dry resin.Pungent, hardship, it is mild-natured;Return The heart, liver, the spleen channel;With scattered stasis pain, the effect of detumescence and promoting granulation;For arthralgia pain due to rheumatism, traumatic injury, carbuncle swells sore.
(18) berba aristolochiae mollissimae:This product is the perennial rhizome for climbing up by holding on to herbaceous plant aristolochia mollissima of Aristolochiaceae.Pungent, Hardship, it is mild-natured;Return liver, stomach;There are the function of wind-damp dispelling, degrading the channel and analgesic, main arthralgia pain due to rheumatism, extremity numbness, muscles and bones contraction, gastral cavity Abdomen pain, traumatic injury, traumatism and bleeding, stomachache etc..
(19) lopseed:Dispelling wind and eliminating dampness, stimulates the circulation of the blood and cause the muscles and joints to relax, promoting blood circulation and stopping pain/dispelling wind and eliminating dampness, stimulate the circulation of the blood and cause the muscles and joints to relax, solution poisons rash, control Treat traumatic injury, carbuncle.
(20) camphor:This product is the branch, dry, leaf and root of canella camphor tree, through refining obtained crystalline particulate.Taste It is pungent, property heat;The thoughts of returning home, the spleen channel;There is orifice opening, qi stagnation removing, ward off that foul, desinsection is antipruritic, swelling and pain relieving, mange scabies is cured mainly Itch, injuries from falls as well, the symptom such as toothache.
(21) rosin:This product is pinaceae plant masson pine, Chinese pine or belongs to the resin removing volatile oil of several plants together Afterwards, the hard resin retained.It is bitter, sweet, it is warm-natured;Return liver, the spleen channel;Dispel pathogenic wind and remove dampness, apocenosis is drawn out pus by applying a plaster to the affected part, myogenic pain relieving.It is applied to Carbuncle furuncle sore, eczema, traumatism and bleeding, burn and scald.
(22) minium:It is pungent, salty, it is cold in nature;It is poisonous.The thoughts of returning home, spleen, liver, courage, kidney channel;Removing toxic substances is dispelled corruption, hygroscopic sore, Promoting expectoration to arrest convulsion.Cure mainly, ulcer sores, external piles, eczema, burn and scald, ulcer, metal-inflicted wound bleeding, aphtha mesh screen.
Above-mentioned each component is known Chinese medicine, can be by commercially available.
Preferably, pharmaceutical composition of the present invention, by weight, its active component is by the original including following components Material is prepared from:5-12 parts of Chinese ephedra, 5-12 parts of rheum officinale, post 10-18 parts of slave, 10-18 parts of Radix Aconiti, 10-18 parts of Radix Aconiti Kusnezoffii, turpentine 15-28 parts, 6-12 parts of pawpaw, 5-12 parts of cassia twig, 8-15 parts of ramulus mori, 8-12 parts of the root of bidentate achyranthes, 8-12 parts of anisetree bark, 6-12 parts of peach kernel, 6-12 parts of safflower, 6-12 parts of earthworm, 10-18 parts of Semen Strychni, 10-18 parts of frankincense, 10-18 parts of myrrh, 10-18 parts of berba aristolochiae mollissimae, 10-18 parts of 10-18 parts of lopseed and camphor.
Composition can give play to relatively significantly synergistic function in the range of above-mentioned amount ratio.
Pharmaceutical composition of the present invention, only can constitute (such as commercially available each active raw materials by material medicine After prepare), or further comprise that pharmaceutically acceptable auxiliary material is prepared into pharmaceutical preparation.
Preferably, pharmaceutical composition of the present invention can be liniment, paste, paste or patch.
Preferably, pharmaceutical composition of the present invention is paste.
Paste of the present invention is the paste that the active component prepared by above-mentioned raw materials is made with suitable matrix, It is coated in base fabric and is sticked for skin, a kind of systemic or local action preparation can be produced.
Paste plays a role through skin, and emplastrum agent therapy is one of conventional outer treating method of tcm clinical practice, and it follows the traditional Chinese medical science Diagnosis and treatment and effect of Chinese medicine, cure mainly principle with channel tropism, give full play to medicine coordinate mutually for efficiency, composition multi-flavor The compound of medicine, to play the good result of medicine.Because paste is directly applied to body surface, and the most gas of medicine for making paste Taste is denseer, adds Xin Xiang and walks to alter extremely strong tying-in medicine, by infiltrating through skin, interior transmission from one channel to another network, internal organs, play regulating the qi flowing in the channels blood, Degrading the channel, cold dispelling are wet, the effect such as detumescence pain.The externally applied ointment of the present invention is easy to use, evident in efficacy, can effective reduction of patient Pain.
Paste of the present invention includes base fabric, the lotion containing the active component and anti-stick layer.
Preferably, the lotion further comprises matrix, and the matrix is rosin plaster substrate, oily wax pattern plaster base Matter, black plaster matrix or white plaster substrate;Preferably rosin plaster substrate.
Preferably, the rosin plaster substrate includes rosin and/or minium.
Preferably, the base fabric is non-woven fabrics, and the non-woven fabrics is conventional commercial product.
Preferably, the anti-stick layer is barrier paper, and the barrier paper is conventional commercial product.
The preparation of aforementioned pharmaceutical compositions (and its each formulation) can use ordinary skill in the art means, and the present invention is to this It is not particularly limited, those skilled in the art can select suitable auxiliary material and preparation method to realize this hair according to actual conditions It is bright.
As the non-limiting embodiments of the present invention, paste of the present invention is prepared by the following method Arrive:After the material medicine immersion of the active component, heating extraction, concentration obtain the active component;Then by the rosin Plaster substrate is added to be well mixed in gained active component, is obtained the lotion, the lotion is coated uniformly in base fabric, then Coated with anti-stick layer, produce the lotion.
Prepared invention also provides aforementioned pharmaceutical compositions for treating promoting blood circulation to remove blood stasis, swelling and pain relieving, wind-dispelling is removed It is wet;Promote union, in the medicine of the bone diseases such as disc herniation, osteoporosis, arthralgia, rheumatalgia, bruise Application.Pharmaceutical composition its Small side effects of the present invention, instant effect, it is inexpensive, easy to use, to analgesic, promote bone uptake tool Have and preferably act on.
Embodiment
With reference to embodiment, the embodiment to the present invention is described in further detail.Following examples are used for Illustrate the present invention, but be not limited to the scope of the present invention.Each raw material in following examples is conventional commercial product.
Wherein, paste of the present invention can be prepared by the following method and obtain:The material medicine of active component is immersed into fiber crops In oil, intense fire is heated to after boiling, and slow fire is heated 3-8 hours, and then filtering removes filter residue, produces active component;Then by pine Fragrant and minium is added into gained active component, is heated and is stirred to well mixed, cooling, produces lotion, gained lotion is applied Overlay on non-woven fabrics, and coated with barrier paper, produce the paste.
Embodiment 1
A kind of pharmaceutical composition is present embodiments provided, described pharmaceutical composition is prepared by following components:Chinese ephedra 10 Part, 10 parts of rheum officinale, post 15 parts of slave, 15 parts of Radix Aconiti, 15 parts of Radix Aconiti Kusnezoffii, 25 parts of turpentine, 10 parts of pawpaw, 10 parts of cassia twig, ramulus mori 10 Part, 10 parts of the root of bidentate achyranthes, 10 parts of anisetree bark, 10 parts of peach kernel, 10 parts of safflower, 10 parts of earthworm, 15 parts of Semen Strychni, 15 parts of frankincense, myrrh 15 parts of 15 parts, 15 parts of berba aristolochiae mollissimae, 15 parts of lopseed and camphor.
Embodiment 2
A kind of pharmaceutical composition is present embodiments provided, described pharmaceutical composition is prepared by following components:Chinese ephedra 8 Part, 8 parts of rheum officinale, post 18 parts of slave, 18 parts of Radix Aconiti, 12 parts of Radix Aconiti Kusnezoffii, 20 parts of turpentine, 8 parts of pawpaw, 8 parts of cassia twig, 12 parts of ramulus mori, 12 parts of the root of bidentate achyranthes, 12 parts of anisetree bark, 8 parts of peach kernel, 12 parts of safflower, 12 parts of earthworm, 10 parts of Semen Strychni, 17 parts of frankincense, 12 parts of myrrh, 18 parts of 12 parts of berba aristolochiae mollissimae, 18 parts of lopseed and camphor.
Embodiment 3
A kind of pharmaceutical composition is present embodiments provided, described pharmaceutical composition is prepared by following components:Chinese ephedra 5 Part, 12 parts of rheum officinale, post 10 parts of slave, 10 parts of Radix Aconiti, 10 parts of Radix Aconiti Kusnezoffii, 28 parts of turpentine, 6 parts of pawpaw, 12 parts of cassia twig, 8 parts of ramulus mori, 12 parts of the root of bidentate achyranthes, 12 parts of anisetree bark, 6 parts of peach kernel, 12 parts of safflower, 12 parts of earthworm, 10 parts of Semen Strychni, 10 parts of frankincense, 18 parts of myrrh, 18 parts of 10 parts of berba aristolochiae mollissimae, 18 parts of lopseed and camphor.
Embodiment 4
A kind of paste is present embodiments provided, the paste includes base fabric, lotion and anti-stick layer;Wherein, the base fabric For non-woven fabrics, the anti-stick layer is barrier paper;The lotion includes matrix and material medicine, wherein, the matrix is by rosin 200 140 parts of part and minium are prepared, and the material medicine is prepared from by the raw material of following components:12 parts of Chinese ephedra, 5 parts of rheum officinale, Post 18 parts of slave, 18 parts of Radix Aconiti, 18 parts of Radix Aconiti Kusnezoffii, 15 parts of turpentine, 12 parts of pawpaw, 5 parts of cassia twig, 15 parts of ramulus mori, 8 parts of the root of bidentate achyranthes, 8 parts of maple skin, 12 parts of peach kernel, 6 parts of safflower, 6 parts of earthworm, 18 parts of Semen Strychni, 18 parts of frankincense, 10 parts of myrrh, 18 parts of berba aristolochiae mollissimae, thoroughly Bone grass 10 parts, 10 parts of camphor.
Embodiment 5
A kind of paste is present embodiments provided, compared with Example 4, it is differed only in, the matrix is by 220 parts of rosin 120 parts are prepared with minium, and the material medicine is prepared from by the raw material of following components:15 parts of Chinese ephedra, 15 parts of rheum officinale, post 20 parts of slave, 20 parts of Radix Aconiti, 20 parts of Radix Aconiti Kusnezoffii, 12 parts of turpentine, 6 parts of pawpaw, 3 parts of cassia twig, 6 parts of ramulus mori, 6 parts of the root of bidentate achyranthes, anisetree bark 6 Part, 3 parts of peach kernel, 3 parts of safflower, 3 parts of earthworm, 8 parts of Semen Strychni, 20 parts of frankincense, 20 parts of myrrh, 20 parts of berba aristolochiae mollissimae, lopseed 20 20 parts of part and camphor.
Embodiment 6
A kind of paste is present embodiments provided, compared with Example 4, it is differed only in, the matrix is by 150 parts of rosin 200 parts are prepared with minium, and the material medicine is prepared from by the raw material of following components:3 parts of Chinese ephedra, 3 parts of rheum officinale, post slave 8 parts, 8 parts of Radix Aconiti, 8 parts of Radix Aconiti Kusnezoffii, 30 parts of turpentine, 15 parts of pawpaw, 15 parts of cassia twig, 15 parts of ramulus mori, 15 parts of the root of bidentate achyranthes, anisetree bark 15 Part, 15 parts of peach kernel, 15 parts of safflower, 15 parts of earthworm, 20 parts of Semen Strychni, 8 parts of frankincense, 8 parts of myrrh, 8 parts of berba aristolochiae mollissimae, lopseed 8 8 parts of part and camphor.
Embodiment 7
A kind of paste is present embodiments provided, compared with Example 4, it is differed only in, the matrix is by 170 parts of rosin 190 parts are prepared with minium, and the material medicine is prepared from by the raw material of following components:12 parts of Chinese ephedra, 5 parts of rheum officinale, post 18 parts of slave, 18 parts of Radix Aconiti, 18 parts of Radix Aconiti Kusnezoffii, 15 parts of turpentine, 12 parts of pawpaw, 5 parts of cassia twig, 15 parts of ramulus mori, 8 parts of the root of bidentate achyranthes, maple It is 8 parts of skin, 12 parts of peach kernel, 6 parts of safflower, 6 parts of earthworm, 18 parts of Semen Strychni, 18 parts of frankincense, 10 parts of myrrh, 18 parts of berba aristolochiae mollissimae, deep 10 parts of 10 parts of grass and camphor.
Embodiment 8
A kind of paste is present embodiments provided, compared with Example 4, it is differed only in, the matrix is by 190 parts of rosin 160 parts prepare with minium, and the material medicine is the pharmaceutical composition described in embodiment 1.
Embodiment 9
A kind of paste is present embodiments provided, compared with Example 4, it is differed only in, the matrix is by 200 parts of rosin 180 parts prepare with minium, and the material medicine is the pharmaceutical composition described in embodiment 2.
Test example 1
This test example is treated to traumatic injury, and specific experiment is as follows:
Experimental subjects:Liu so-and-so, man, 22 years old;
Symptom:Ankle from sprains when playing football;
Test method:Paste described in embodiment 8 is applied to patient affected part, the symptom after observation administration.
As a result it is:After one day, swell and ache and alleviated;Recover using being fully recovered after three days.
Test example 2
This test example is treated to treatment arthralgia, and specific experiment is as follows:
Experimental subjects:Lee, man, 52 years old;
Symptom:Suffer from treating rheumatic ostealgia half a year;
Test method:Paste described in embodiment 8 is applied to patient affected part, the symptom after observation administration.
As a result it is:After one week, symptom has been alleviated;Fully recovered using after one month.
As can be seen here, the pharmaceutical composition described herein comprising special component and consumption is in treatment traumatic injury, pass Section pain, fracture, which swell and ache etc. in terms of disease, has significant effect, has broad application prospects.
Although above with general explanation and specific embodiment, the present invention is described in detail, at this On the basis of invention, it can be made some modifications or improvements, this will be apparent to those skilled in the art.Therefore, These modifications or improvements, belong to the scope of protection of present invention without departing from theon the basis of the spirit of the present invention.

Claims (10)

1. a kind of pharmaceutical composition, it is characterised in that by weight, its active component is prepared by the raw material including following components Form:3-15 parts of Chinese ephedra, 3-15 parts of rheum officinale, post 8-20 parts of slave, 8-20 parts of Radix Aconiti, 8-20 parts of Radix Aconiti Kusnezoffii, 12-30 parts of turpentine, 6-15 parts of pawpaw, 3-15 parts of cassia twig, 6-15 parts of ramulus mori, 6-15 parts of the root of bidentate achyranthes, 6-15 parts of anisetree bark, 3-15 parts of peach kernel, safflower 3-15 Part, 3-15 parts of earthworm, 8-20 parts of Semen Strychni, 8-20 parts of frankincense, 8-20 parts of myrrh, 8-20 parts of berba aristolochiae mollissimae, 8-20 parts of lopseed With 8-20 parts of camphor.
2. pharmaceutical composition according to claim 1, it is characterised in that by weight, its active component by including with The raw material of lower component is prepared from:5-12 parts of Chinese ephedra, 5-12 parts of rheum officinale, post 10-18 parts of slave, 10-18 parts of Radix Aconiti, Radix Aconiti Kusnezoffii 10-18 parts, 15-28 parts of turpentine, 6-12 parts of pawpaw, 5-12 parts of cassia twig, 8-15 parts of ramulus mori, 8-12 parts of the root of bidentate achyranthes, 8-12 parts of anisetree bark, 6-12 parts of peach kernel, 6-12 parts of safflower, 6-12 parts of earthworm, 10-18 parts of Semen Strychni, 10-18 parts of frankincense, 10-18 parts of myrrh, seek bone 10-18 parts of 10-18 parts of wind, 10-18 parts of lopseed and camphor.
3. pharmaceutical composition according to claim 1 or 2, it is characterised in that described pharmaceutical composition be liniment, paste, Paste or patch.
4. pharmaceutical composition according to claim 3, it is characterised in that described pharmaceutical composition is paste.
5. pharmaceutical composition according to claim 4, it is characterised in that the paste includes base fabric, containing described The lotion of active component and anti-stick layer.
6. pharmaceutical composition according to claim 5, it is characterised in that also include matrix, the matrix in the lotion For rosin plaster substrate, oily wax pattern plaster substrate, black plaster matrix or white plaster substrate.
7. pharmaceutical composition according to claim 6, it is characterised in that the matrix is rosin plaster substrate.
8. pharmaceutical composition according to claim 7, it is characterised in that the rosin plaster substrate include rosin and/or Minium.
9. the pharmaceutical composition according to claim any one of 5-8, it is characterised in that the base fabric is non-woven fabrics.
10. the pharmaceutical composition described in claim any one of 1-9 is preparing treatment promoting blood circulation to remove blood stasis, swelling and pain relieving, dispelling wind and eliminating dampness; Promote union, to the application in disc herniation, osteoporosis, arthralgia, rheumatalgia, bruise medicine.
CN201710349521.1A 2017-05-17 2017-05-17 A kind of pharmaceutical composition and its application for being used to relieving pain, promoting bone uptake Pending CN107213225A (en)

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Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110013513A (en) * 2019-05-21 2019-07-16 郑州巨人生化集团有限公司 A kind of external-use gel and preparation method thereof for treating treating rheumatic ostealgia
CN110812467A (en) * 2019-12-12 2020-02-21 河南中医药大学 External pine and cinnamon essential oil for promoting fracture rehabilitation

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103211932A (en) * 2013-03-18 2013-07-24 赵霞 Traditional Chinese medicine composition for treating rheumatism
CN105726807A (en) * 2016-03-24 2016-07-06 王伟民 Traditional Chinese medicine for treating osteoarticular diseases and preparation method for traditional Chinese medicine

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103211932A (en) * 2013-03-18 2013-07-24 赵霞 Traditional Chinese medicine composition for treating rheumatism
CN105726807A (en) * 2016-03-24 2016-07-06 王伟民 Traditional Chinese medicine for treating osteoarticular diseases and preparation method for traditional Chinese medicine

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110013513A (en) * 2019-05-21 2019-07-16 郑州巨人生化集团有限公司 A kind of external-use gel and preparation method thereof for treating treating rheumatic ostealgia
CN110013513B (en) * 2019-05-21 2021-11-16 郑州巨人生化集团有限公司 External gel for treating rheumatic ostealgia and preparation method thereof
CN110812467A (en) * 2019-12-12 2020-02-21 河南中医药大学 External pine and cinnamon essential oil for promoting fracture rehabilitation

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Application publication date: 20170929