CN107212406A - Composition of effect and preparation method thereof is encouraged with intelligence development - Google Patents
Composition of effect and preparation method thereof is encouraged with intelligence development Download PDFInfo
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Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/105—Plant extracts, their artificial duplicates or their derivatives
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
Abstract
The present invention relates to a kind of composition and preparation method thereof that effect is encouraged with intelligence development, the raw material components of composition by weight, including：The parts by weight of meat 40~50, the parts by weight of fennel 2~5, the parts by weight of cassia bark 3~6, the parts by weight of capsicum 1~3, the parts by weight of garlic 2~4, the parts by weight of ginger 4~6, the parts by weight of mushroom 10~15, the parts by weight of hawthorn 5~10, the parts by weight of celery 8~12, the parts by weight of balsam pear 7~11, the parts by weight of jujube 5~10, the parts by weight of carrot 10~15, the parts by weight of walnut kernel 15~25 and the parts by weight of cashew nut kernel 10~15.The composition that the present invention is provided can promote the growth and intelligence development of children, can slow down the amnesia and insomnia of palpitating with fear of the elderly；And good mouthfeel, safe without toxic side effect, are easy to long-term taking；Preparation method is simple, and production cost is low.
Description
Technical field
The present invention relates to food technology field, and in particular to a kind of composition and its preparation side that effect is encouraged with intelligence development
Method.
Background technology
With the development of modern society, people increasingly pay close attention to the physical and mental health of oneself, and various health products are even more
It is full of whole market.The healthy growth of youngsters and children is a process synchronously carried out with intelligence development of growing, if
Nutrition does not catch up with, easily the development of influence height or intelligence.Concern promotes life more than the medicine or health products sold in the market
Long development on one side, often ignores the influence to intelligence development.Also, medicine present in prior art or health products are past
It is past expensive, or there is side effect, it is not suitable for being used for a long time, and intelligence development or growth encourage effect also have much room for improvement.Therefore, need
New safely and effectively product is developed, to avoid the defect of existing product.
The content of the invention
For defect of the prior art, present invention aims at provide it is a kind of with intelligence development encourage effect composition and
Its preparation method, with improve composition promote children growth and intelligence development, slow down the elderly amnesia and
Effect of insomnia of palpitating with fear, safe without toxic side effect；And good mouthfeel, is easy to long-term taking；Preparation method is simple, production cost
It is low.
To achieve the above object, the technical scheme that provides of the present invention is：
In a first aspect, the invention provides a kind of composition that effect is encouraged with intelligence development, the raw material components of composition are pressed
Parts by weight meter, including：It is the parts by weight of meat 40~50, the parts by weight of fennel 2~5, the parts by weight of cassia bark 3~6, the parts by weight of capsicum 1~3, big
The parts by weight of garlic 2~4, the parts by weight of ginger 4~6, the parts by weight of mushroom 10~15, the parts by weight of hawthorn 5~10, the parts by weight of celery 8~12,
The parts by weight of balsam pear 7~11, the parts by weight of jujube 5~10, the parts by weight of carrot 10~15, the parts by weight of walnut kernel 15~25 and cashew nut kernel
10~15 parts by weight.
In the further embodiment of the present invention, one kind in pork, beef, mutton, chicken and duck of meat or
It is a variety of.
In the further embodiment of the present invention, the raw material components of composition also include the weight of Chinese medical extract 20~30
Part, the raw material components of Chinese medical extract by weight, including：The parts by weight of ginseng 10~12, the parts by weight of rhizoma Gastrodiae 15~20, the Radix Astragali
3~8 parts by weight, the parts by weight of matrimony vine 4~6, the parts by weight of the coptis 2~5, the parts by weight of radix bupleuri 7~10, the parts by weight of the root of kudzu vine 13~15, Fu
The parts by weight of Siberian cocklebur 8~10, the parts by weight of the bighead atractylodes rhizome 3~6, windproof 5~9 parts by weight, the parts by weight of dried orange peel 3~7, the parts by weight of Ligusticum wallichii 1~4, when
Return 6~10 parts by weight, the parts by weight of folium artemisiae argyi 8~12, the parts by weight of the red sage root 7~10, the parts by weight of Fructus meliae toosendan 5~15, the weight of pseudo-ginseng 5~10
Part, the parts by weight of ganoderma lucidum 2~4 and the parts by weight of the stem of noble dendrobium 3~5.
In the further embodiment of the present invention, the preparation method of Chinese medical extract comprises the following steps：S101：Will
All raw material components are put into ethanol water, are heated, are then filtered after immersion, and filtrate and filter residue are collected respectively；S102：Will filter
Slag carries out refluxing extraction, then filters, and collects filtrate；S103：The S101 filtrates collected and the S102 filtrate collected are merged, so
Reduction vaporization concentration is carried out afterwards, obtains concentrate；S104：By concentrate drying to constant weight, Chinese medical extract is obtained.Need explanation
, the ethanol that the present invention is used is food-grade, without including industrial alcohol.
In the further embodiment of the present invention, in S101, the quality of ethanol water is total with all raw material components
The ratio of quality is (15~20):1, the volume fraction of ethanol water is 40%~50%；The time of immersion is 8~10h；Plus
The temperature of heat is 85~95 DEG C, and the time of heating is 80~100min.
The present invention further embodiment in, in S102, in refluxing extraction, extract solution be volume fraction 50%~
The ratio of 60% ethanol water, the volume of extract solution and the quality of filter residue is (10~20) mL:1g.
In the further embodiment of the present invention, in S103, the temperature that concentration is evaporated under reduced pressure is 40~50 DEG C, and decompression is steamed
The pressure of hair concentration is 65~70mmHg, and the Baume degrees of concentrate is 1.2~1.3.
In the further embodiment of the present invention, in S104, dry to be spray-dried, wherein：EAT be 100~
120 DEG C, leaving air temp is 50~60 DEG C, and feed rate is 10~20mL/min.
Second aspect, the invention provides the preparation method for the composition that effect is encouraged with intelligence development, comprises the following steps：
S1：By the chopping of meat, mushroom, hawthorn, celery, balsam pear, jujube, ginger and carrot, then mixed with fennel, cassia bark, capsicum, garlic
Close uniform, be then placed in heater and heat；S2：Other raw material components are crushed, the product mixing then obtained with S1 is equal
Even, encapsulation sterilizing obtains composition.
In the further embodiment of the present invention, in S1, the temperature adjustment of heater includes：From 20~30 DEG C with 2
~5 DEG C/min heating rate is down to 55~60 DEG C, is incubated 60~70min；Then with 1.5~2.5 DEG C/min heating rate
120~140 DEG C are risen to, 30~40min is incubated；Then 20~30 DEG C are down to 1~2 DEG C/min rate of temperature fall.
It should be noted that the eating method for the composition for encouraging effect with intelligence development that the present invention is prepared is preferred
For：50~100g is eaten every time, 2 times (morning, noon eat once in each before meals) is eaten daily, children are edible with aobvious
The intelligence development growth encourage of work and the effect of health care, mid-aged population is edible to have preferable intelligence development and health-care effect.
The technical scheme that the present invention is provided, with following beneficial effect：(1) composition that provides of the present invention, from containing
There are the raw-food material and Chinese medicinal material of active skull cap components, prescription proportioning science, without any Western medicine hormonal components, safe nothing
Toxic side effect, with the growth and intelligence development for promoting children, can slow down the amnesia and insomnia of palpitating with fear of the elderly
Effect；(2) preparation method for the composition that the present invention is provided, each raw material active component can be retained to greatest extent, so that
Make the composition finally prepared, not only with good effect, and be easy to absorb；(3) composition that the present invention is provided
Preparation method is simple, and production cost is low.
The additional aspect and advantage of the present invention will be set forth in part in the description, and will partly become from the following description
Obtain substantially, or recognized by the practice of the present invention.
Embodiment
Below in conjunction with the embodiment of the present invention, technical scheme is clearly and completely described.Implement below
Example is only used for clearly illustrating technical scheme, therefore is intended only as example, and can not limit this hair with this
Bright protection domain.
Experimental method in following embodiments, is conventional method unless otherwise specified.Examination used in following embodiments
Material is tested, is to be commercially available from regular shops unless otherwise specified.Quantitative test in following examples, is respectively provided with three
Secondary to repeat to test, data are the average value or mean+SD of three repetition experiments.
Ginseng used in following embodiments, rhizoma Gastrodiae, the Radix Astragali, matrimony vine, the coptis, radix bupleuri, the root of kudzu vine, Poria cocos, the bighead atractylodes rhizome, it is windproof,
Dried orange peel, Ligusticum wallichii, Radix Angelicae Sinensis, folium artemisiae argyi, the red sage root, Fructus meliae toosendan, pseudo-ginseng, ganoderma lucidum and the stem of noble dendrobium are meeting Chinese Pharmacopoeia (version in 2015) one just
Pertinent regulations under each medicinal material of text.Before feeding intake, by identification, ingredients material object is consistent with title, and quality meets standard.
The present invention provides a kind of composition that effect is encouraged with intelligence development, and the raw material components of composition by weight, are wrapped
Include：The parts by weight of meat 40~50, the parts by weight of fennel 2~5, the parts by weight of cassia bark 3~6, the parts by weight of capsicum 1~3, the weight of garlic 2~4
Part, the parts by weight of ginger 4~6, the parts by weight of mushroom 10~15, the parts by weight of hawthorn 5~10, the parts by weight of celery 8~12, balsam pear 7~11
Parts by weight, the parts by weight of jujube 5~10, the parts by weight of carrot 10~15, the parts by weight of walnut kernel 15~25 and the weight of cashew nut kernel 10~15
Part；Wherein, one or more of the meat in pork, beef, mutton, chicken and duck.
Preferably, the raw material components of composition also include the parts by weight of Chinese medical extract 20~30, the raw material of Chinese medical extract
Component by weight, including：The parts by weight of ginseng 10~12, the parts by weight of rhizoma Gastrodiae 15~20, the parts by weight of the Radix Astragali 3~8, matrimony vine 4~6
Parts by weight, the parts by weight of the coptis 2~5, the parts by weight of radix bupleuri 7~10, the parts by weight of the root of kudzu vine 13~15, the parts by weight of Poria cocos 8~10, the bighead atractylodes rhizome 3
~6 parts by weight, windproof 5~9 parts by weight, the parts by weight of dried orange peel 3~7, the parts by weight of Ligusticum wallichii 1~4, the parts by weight of Radix Angelicae Sinensis 6~10, folium artemisiae argyi 8
~12 parts by weight, the parts by weight of the red sage root 7~10, the parts by weight of Fructus meliae toosendan 5~15, the parts by weight of pseudo-ginseng 5~10, the parts by weight of ganoderma lucidum 2~4 and
The parts by weight of the stem of noble dendrobium 3~5.The preparation method of Chinese medical extract, comprises the following steps：
S101：All raw material components are put into the ethanol water that volume fraction is 40%~50%, soak 8~10h
Afterwards, 85~95 DEG C of 80~100min of heating, are then filtered, and filtrate and filter residue are collected respectively；Wherein, the quality of ethanol water with
The ratio of the gross mass of all raw material components is (15~20):1.
S102：Filter residue is subjected to refluxing extraction, then filtered, filtrate is collected；Wherein, extract solution be volume fraction 50%~
The ratio of 60% ethanol water, the volume of extract solution and the quality of filter residue is (10~20) mL:1g.
S103：The S101 filtrates collected and the S102 filtrate collected are merged, reduction vaporization concentration is then carried out, obtains dense
Contracting liquid；Wherein, the temperature that concentration is evaporated under reduced pressure is 40~50 DEG C, and the pressure that concentration is evaporated under reduced pressure is 65~70mmHg, concentrate
Baume degrees be 1.2~1.3.
S104：By concentrate drying to constant weight, Chinese medical extract is obtained；Wherein, dry to be spray-dried, wherein：Air intake
Temperature is 100~120 DEG C, and leaving air temp is 50~60 DEG C, and feed rate is 10~20mL/min.
In addition, present invention also offers the preparation method of the above-mentioned composition that effect is encouraged with intelligence development, including following step
Suddenly：
S1：By the chopping of meat, mushroom, hawthorn, celery, balsam pear, jujube, ginger and carrot, then with fennel, cassia bark, peppery
Green pepper, garlic are well mixed, and are then placed in heater and heat；Wherein, the temperature adjustment of heater includes：From 20~30 DEG C
55~60 DEG C are down to 2~5 DEG C/min heating rate, 60~70min is incubated；Then with 1.5~2.5 DEG C/min heating speed
Rate rises to 120~140 DEG C, is incubated 30~40min；Then 20~30 DEG C are down to 1~2 DEG C/min rate of temperature fall.
S2：Other surplus stock components are crushed, the product then obtained with S1 is well mixed, encapsulation sterilizing obtains group
Compound.
Composition that there is intelligence development to encourage effect provided with reference to specific embodiment the present invention and preparation method thereof
It is described further.
Embodiment one
The present embodiment provide it is a kind of encourage the composition of effect with intelligence development, raw material components by weight, including：Beef
50 parts by weight, the parts by weight of fennel 2, the parts by weight of cassia bark 6, the parts by weight of capsicum 1, the parts by weight of garlic 4, the parts by weight of ginger 4, the weight of mushroom 15
Measure part, the parts by weight of hawthorn 5, the parts by weight of celery 12, the parts by weight of balsam pear 7, the parts by weight of jujube 10, the parts by weight of carrot 10, walnut kernel 25
Parts by weight and the parts by weight of cashew nut kernel 10.
By above-mentioned raw material, prepared by the preparation method of the composition that there is intelligence development to encourage effect provided using the present invention
The composition of effect is encouraged with intelligence development：
S1：By the chopping of beef, mushroom, hawthorn, celery, balsam pear, jujube, ginger and carrot, then with fennel, cassia bark, peppery
Green pepper, garlic are well mixed, and are then placed in heater and heat；Wherein, the temperature adjustment of heater includes：From 30 DEG C with 5
DEG C/min heating rate is down to 60 DEG C, is incubated 70min；Then 140 DEG C, insulation are risen to 2.5 DEG C/min heating rate
40min；Then 30 DEG C are down to 2 DEG C/min rate of temperature fall.
S2：Other surplus stock components are crushed, the product then obtained with S1 is well mixed, encapsulation sterilizing obtains group
Compound.
Embodiment two
The present embodiment provide it is a kind of encourage the composition of effect with intelligence development, raw material components by weight, including：Beef
40 parts by weight, the parts by weight of fennel 5, the parts by weight of cassia bark 3, the parts by weight of capsicum 3, the parts by weight of garlic 2, the parts by weight of ginger 6, the weight of mushroom 10
Measure part, the parts by weight of hawthorn 10, the parts by weight of celery 8, the parts by weight of balsam pear 11, the parts by weight of jujube 5, the parts by weight of carrot 15, walnut kernel 15
Parts by weight and the parts by weight of cashew nut kernel 15.
By above-mentioned raw material, prepared by the preparation method of the composition that there is intelligence development to encourage effect provided using the present invention
The composition of effect is encouraged with intelligence development：
S1：By the chopping of beef, mushroom, hawthorn, celery, balsam pear, jujube, ginger and carrot, then with fennel, cassia bark, peppery
Green pepper, garlic are well mixed, and are then placed in heater and heat；Wherein, the temperature adjustment of heater includes：From 20 DEG C with 2
DEG C/min heating rate is down to 55 DEG C, is incubated 60min；Then 120 DEG C, insulation are risen to 1.5 DEG C/min heating rate
30min；Then 20 DEG C are down to 1 DEG C/min rate of temperature fall.
S2：Other surplus stock components are crushed, the product then obtained with S1 is well mixed, encapsulation sterilizing obtains group
Compound.
Embodiment three
The present embodiment provide it is a kind of encourage the composition of effect with intelligence development, raw material components by weight, including：Beef
45 parts by weight, the parts by weight of fennel 4, the parts by weight of cassia bark 5, the parts by weight of capsicum 2, the parts by weight of garlic 3, the parts by weight of ginger 5, the weight of mushroom 12
Measure part, the parts by weight of hawthorn 8, the parts by weight of celery 10, the parts by weight of balsam pear 9, the parts by weight of jujube 8, the parts by weight of carrot 12, walnut kernel 20
Parts by weight and the parts by weight of cashew nut kernel 13.
By above-mentioned raw material, prepared by the preparation method of the composition that there is intelligence development to encourage effect provided using the present invention
The composition of effect is encouraged with intelligence development：
S1：By the chopping of beef, mushroom, hawthorn, celery, balsam pear, jujube, ginger and carrot, then with fennel, cassia bark, peppery
Green pepper, garlic are well mixed, and are then placed in heater and heat；Wherein, the temperature adjustment of heater includes：From 25 DEG C with 3
DEG C/min heating rate is down to 58 DEG C, is incubated 65min；Then 130 DEG C, insulation are risen to 2 DEG C/min heating rate
35min；Then 25 DEG C are down to 1.5 DEG C/min rate of temperature fall.
S2：Other surplus stock components are crushed, the product then obtained with S1 is well mixed, encapsulation sterilizing obtains group
Compound.
Example IV
The present embodiment provide it is a kind of encourage the composition of effect with intelligence development, raw material components by weight, including：Beef
50 parts by weight, the parts by weight of fennel 2, the parts by weight of cassia bark 6, the parts by weight of capsicum 1, the parts by weight of garlic 4, the parts by weight of ginger 4, the weight of mushroom 15
Measure part, the parts by weight of hawthorn 5, the parts by weight of celery 12, the parts by weight of balsam pear 7, the parts by weight of jujube 10, the parts by weight of carrot 10, walnut kernel 25
Parts by weight, the parts by weight of cashew nut kernel 10 and the parts by weight of Chinese medical extract 20~30；
Wherein, the raw material components of Chinese medical extract by weight, including：The parts by weight of ginseng 12, the parts by weight of rhizoma Gastrodiae 15, Huang
The parts by weight of stilbene 8, the parts by weight of matrimony vine 4, the parts by weight of the coptis 5, the parts by weight of radix bupleuri 7, the parts by weight of the root of kudzu vine 15, the parts by weight of Poria cocos 8, the bighead atractylodes rhizome 6
Parts by weight, windproof 5 parts by weight, the parts by weight of dried orange peel 7, the parts by weight of Ligusticum wallichii 1, the parts by weight of Radix Angelicae Sinensis 10, the parts by weight of folium artemisiae argyi 8, the weight of the red sage root 10
Measure part, the parts by weight of Fructus meliae toosendan 5, the parts by weight of pseudo-ginseng 10, the parts by weight of ganoderma lucidum 2 and the parts by weight of the stem of noble dendrobium 5；The preparation side of Chinese medical extract
Method, comprises the following steps：
S101：All raw material components are put into the ethanol water that volume fraction is 50%, after immersion 10h, 95 DEG C add
Hot 100min, is then filtered, and filtrate and filter residue are collected respectively；Wherein, the quality of ethanol water and all raw material components is total
The ratio of quality is 20:1.
S102：Filter residue is subjected to refluxing extraction, then filtered, filtrate is collected；Wherein, extract solution is volume fraction 60%
The ratio of ethanol water, the volume of extract solution and the quality of filter residue is 20mL:1g.
S103：The S101 filtrates collected and the S102 filtrate collected are merged, reduction vaporization concentration is then carried out, obtains dense
Contracting liquid；Wherein, the temperature that concentration is evaporated under reduced pressure is 50 DEG C, and the pressure that concentration is evaporated under reduced pressure is 70mmHg, the Baume degrees of concentrate
For 1.3.
S104：By concentrate drying to constant weight, Chinese medical extract is obtained；Wherein, dry to be spray-dried, wherein：Air intake
Temperature is 120 DEG C, and leaving air temp is 60 DEG C, and feed rate is 20mL/min.
By above-mentioned raw material, prepared by the preparation method of the composition that there is intelligence development to encourage effect provided using the present invention
The composition of effect is encouraged with intelligence development：
S1：By the chopping of beef, mushroom, hawthorn, celery, balsam pear, jujube, ginger and carrot, then with fennel, cassia bark, peppery
Green pepper, garlic are well mixed, and are then placed in heater and heat；Wherein, the temperature adjustment of heater includes：From 30 DEG C with 5
DEG C/min heating rate is down to 60 DEG C, is incubated 70min；Then 140 DEG C, insulation are risen to 2.5 DEG C/min heating rate
40min；Then 30 DEG C are down to 2 DEG C/min rate of temperature fall.
S2：Other surplus stock components are crushed, the product then obtained with S1 is well mixed, encapsulation sterilizing obtains group
Compound.
Embodiment five
The present embodiment provide it is a kind of encourage the composition of effect with intelligence development, raw material components by weight, including：Beef
40 parts by weight, the parts by weight of fennel 5, the parts by weight of cassia bark 3, the parts by weight of capsicum 3, the parts by weight of garlic 2, the parts by weight of ginger 6, the weight of mushroom 10
Measure part, the parts by weight of hawthorn 10, the parts by weight of celery 8, the parts by weight of balsam pear 11, the parts by weight of jujube 5, the parts by weight of carrot 15, walnut kernel 15
Parts by weight, the parts by weight of cashew nut kernel 15 and the parts by weight of Chinese medical extract 20~30；
Wherein, the raw material components of Chinese medical extract by weight, including：The parts by weight of ginseng 10, the parts by weight of rhizoma Gastrodiae 20, Huang
The parts by weight of stilbene 3, the parts by weight of matrimony vine 6, the parts by weight of the coptis 2, the parts by weight of radix bupleuri 10, the parts by weight of the root of kudzu vine 13, the parts by weight of Poria cocos 10, the bighead atractylodes rhizome
3 parts by weight, windproof 9 parts by weight, the parts by weight of dried orange peel 3, the parts by weight of Ligusticum wallichii 4, the parts by weight of Radix Angelicae Sinensis 6, the parts by weight of folium artemisiae argyi 12, the weight of the red sage root 7
Measure part, the parts by weight of Fructus meliae toosendan 15, the parts by weight of pseudo-ginseng 5, the parts by weight of ganoderma lucidum 4 and the parts by weight of the stem of noble dendrobium 3；The preparation side of Chinese medical extract
Method, comprises the following steps：
S101：All raw material components are put into the ethanol water that volume fraction is 40%, after 8~10h of immersion, 85 DEG C
80min is heated, is then filtered, filtrate and filter residue are collected respectively；Wherein, the quality of ethanol water and all raw material components is total
The ratio of quality is 15:1.
S102：Filter residue is subjected to refluxing extraction, then filtered, filtrate is collected；Wherein, extract solution is volume fraction 50%
The ratio of ethanol water, the volume of extract solution and the quality of filter residue is 10mL:1g.
S103：The S101 filtrates collected and the S102 filtrate collected are merged, reduction vaporization concentration is then carried out, obtains dense
Contracting liquid；Wherein, the temperature that concentration is evaporated under reduced pressure is 40 DEG C, and the pressure that concentration is evaporated under reduced pressure is 65mmHg, the Baume degrees of concentrate
For 1.2.
S104：By concentrate drying to constant weight, Chinese medical extract is obtained；Wherein, dry to be spray-dried, wherein：Air intake
Temperature is 100 DEG C, and leaving air temp is 50 DEG C, and feed rate is 10mL/min.
By above-mentioned raw material, prepared by the preparation method of the composition that there is intelligence development to encourage effect provided using the present invention
The composition of effect is encouraged with intelligence development：
S1：By the chopping of beef, mushroom, hawthorn, celery, balsam pear, jujube, ginger and carrot, then with fennel, cassia bark, peppery
Green pepper, garlic are well mixed, and are then placed in heater and heat；Wherein, the temperature adjustment of heater includes：From 20 DEG C with 2
DEG C/min heating rate is down to 55 DEG C, is incubated 60min；Then 120 DEG C, insulation are risen to 1.5 DEG C/min heating rate
30min；Then 20 DEG C are down to 1 DEG C/min rate of temperature fall.
S2：Other surplus stock components are crushed, the product then obtained with S1 is well mixed, encapsulation sterilizing obtains group
Compound.
Embodiment six
The present embodiment provide it is a kind of encourage the composition of effect with intelligence development, raw material components by weight, including：Beef
45 parts by weight, the parts by weight of fennel 4, the parts by weight of cassia bark 5, the parts by weight of capsicum 2, the parts by weight of garlic 3, the parts by weight of ginger 5, the weight of mushroom 12
Measure part, the parts by weight of hawthorn 8, the parts by weight of celery 10, the parts by weight of balsam pear 9, the parts by weight of jujube 8, the parts by weight of carrot 12, walnut kernel 20
Parts by weight, the parts by weight of cashew nut kernel 13 and the parts by weight of Chinese medical extract 20~30；
Wherein, the raw material components of Chinese medical extract by weight, including：The parts by weight of ginseng 11, the parts by weight of rhizoma Gastrodiae 18, Huang
The parts by weight of stilbene 5, the parts by weight of matrimony vine 5, the parts by weight of the coptis 3, the parts by weight of radix bupleuri 9, the parts by weight of the root of kudzu vine 14, the parts by weight of Poria cocos 9, the bighead atractylodes rhizome 4
Parts by weight, windproof 7 parts by weight, the parts by weight of dried orange peel 5, the parts by weight of Ligusticum wallichii 2, the parts by weight of Radix Angelicae Sinensis 8, the parts by weight of folium artemisiae argyi 10, the weight of the red sage root 8
Part, the parts by weight of Fructus meliae toosendan 10, the parts by weight of pseudo-ginseng 9, the parts by weight of ganoderma lucidum 3 and the parts by weight of the stem of noble dendrobium 4；The preparation method of Chinese medical extract,
Comprise the following steps：
S101：All raw material components are put into the ethanol water that volume fraction is 45%, after immersion 9h, 90 DEG C of heating
90min, is then filtered, and filtrate and filter residue are collected respectively；Wherein, the quality of ethanol water and the gross mass of all raw material components
Ratio be 18:1.
S102：Filter residue is subjected to refluxing extraction, then filtered, filtrate is collected；Wherein, extract solution is volume fraction 55%
The ratio of ethanol water, the volume of extract solution and the quality of filter residue is 15mL:1g.
S103：The S101 filtrates collected and the S102 filtrate collected are merged, reduction vaporization concentration is then carried out, obtains dense
Contracting liquid；Wherein, the temperature that concentration is evaporated under reduced pressure is 45 DEG C, and the pressure that concentration is evaporated under reduced pressure is 65mmHg, the Baume degrees of concentrate
For 1.25.
S104：By concentrate drying to constant weight, Chinese medical extract is obtained；Wherein, dry to be spray-dried, wherein：Air intake
Temperature is 110 DEG C, and leaving air temp is 55 DEG C, and feed rate is 15mL/min.
By above-mentioned raw material, prepared by the preparation method of the composition that there is intelligence development to encourage effect provided using the present invention
The composition of effect is encouraged with intelligence development：
S1：By the chopping of beef, mushroom, hawthorn, celery, balsam pear, jujube, ginger and carrot, then with fennel, cassia bark, peppery
Green pepper, garlic are well mixed, and are then placed in heater and heat；Wherein, the temperature adjustment of heater includes：From 25 DEG C with 3
DEG C/min heating rate is down to 58 DEG C, is incubated 65min；Then 130 DEG C, insulation are risen to 2 DEG C/min heating rate
35min；Then 25 DEG C are down to 1.5 DEG C/min rate of temperature fall.
S2：Other surplus stock components are crushed, the product then obtained with S1 is well mixed, encapsulation sterilizing obtains group
Compound.
Comparative example one
This comparative example provides a kind of composition, raw material components by weight, including：The parts by weight of beef 45, the weight of fennel 4
Part, the parts by weight of cassia bark 5, the parts by weight of capsicum 2, the parts by weight of garlic 3, the parts by weight of ginger 5, the parts by weight of mushroom 12, the parts by weight of hawthorn 8,
The parts by weight of celery 10, the parts by weight of balsam pear 9, the parts by weight of jujube 8, the parts by weight of carrot 12, the parts by weight of walnut kernel 20, the weight of cashew nut kernel 13
Measure part and the parts by weight of Chinese medical extract 20~30；
Wherein, the raw material components of Chinese medical extract by weight, including：The parts by weight of rhizoma Gastrodiae 18, the parts by weight of the Radix Astragali 5, Chinese holly
The parts by weight of Qi 5, the parts by weight of the coptis 3, the parts by weight of radix bupleuri 9, the parts by weight of the root of kudzu vine 14, the parts by weight of Poria cocos 9, windproof 7 parts by weight, dried orange peel 5
Parts by weight, the parts by weight of Ligusticum wallichii 2, the parts by weight of Radix Angelicae Sinensis 8, the parts by weight of folium artemisiae argyi 10, the parts by weight of the red sage root 8, the parts by weight of Fructus meliae toosendan 10, pseudo-ginseng 9
Parts by weight, the parts by weight of ganoderma lucidum 3 and the parts by weight of the stem of noble dendrobium 4；The preparation method be the same as Example six of Chinese medical extract.
The preparation method be the same as Example six of composition.
Comparative example two
This comparative example provides a kind of composition, raw material components by weight, including：The parts by weight of beef 45, the weight of fennel 4
Part, the parts by weight of cassia bark 5, the parts by weight of capsicum 2, the parts by weight of garlic 3, the parts by weight of ginger 5, the parts by weight of mushroom 12, the parts by weight of hawthorn 8,
The parts by weight of celery 10, the parts by weight of balsam pear 9, the parts by weight of jujube 8, the parts by weight of carrot 12, the parts by weight of walnut kernel 20, the weight of cashew nut kernel 13
Measure part and the parts by weight of Chinese medical extract 20~30；
Wherein, the raw material components of Chinese medical extract by weight, including：The parts by weight of ginseng 11, the parts by weight of the Radix Astragali 5, Chinese holly
The parts by weight of Qi 5, the parts by weight of the coptis 3, the parts by weight of radix bupleuri 9, the parts by weight of the root of kudzu vine 14, the parts by weight of the bighead atractylodes rhizome 4, windproof 7 parts by weight, dried orange peel 5
Parts by weight, the parts by weight of Ligusticum wallichii 2, the parts by weight of Radix Angelicae Sinensis 8, the parts by weight of folium artemisiae argyi 10, the parts by weight of the red sage root 8, the parts by weight of Fructus meliae toosendan 10, pseudo-ginseng 9
Parts by weight, the parts by weight of ganoderma lucidum 3 and the parts by weight of the stem of noble dendrobium 4；The preparation method be the same as Example six of Chinese medical extract.
The preparation method be the same as Example six of composition.
The eating method with the intelligence development composition that encourages effect that the present invention is prepared is preferably：Each edible 50~
100g, it is edible 2 times daily (morning, noon in it is each before meals it is edible once), children are edible have significant intelligence development encourage and
The effect of health care, mid-aged population is edible to have preferable intelligence development and health-care effect.
By what the embodiment of the present invention one to embodiment six was prepared there is intelligence development to encourage the composition of effect, pass through function
Learn experiment and carry out system evaluation its effect, and using comparative example one to comparative example two as compareing.
1st, toxicity test
(1) tested food and administration way
Blank control：Physiological saline, it is commercially available.
Test specimen：The composition that effect is encouraged with intelligence development that the embodiment of the present invention three and embodiment six are prepared.
Experimental animal：Rabbit, body weight 2kg or so, male and female half and half are purchased from Experimental Animal Center.
To composition time and dosage：It it is 12 weeks to the composition phase, convalescence is 1 week, to composition using gavage mode
Amount is 0.5g/Kg/ times, once a day.
(2) experimental method and observation index
Experimental animal is grouped at random, is divided into three groups of embodiment, six groups of embodiment and blank control group, except blank control group is given
Give outside physiological saline, remaining group composition agent amount is 0.5g/Kg/ times, every group of animal 10.Continuously give composition 12 weeks；
Control group gavage physiological saline under the same conditions.
Overview：Observe general behavior movable, fecal character, appetite and changes of weight etc., gait, mental act, the heart
Nausea and vomiting etc. are secreted and whether there is in rate, pupil size, nose and oral cavity.Before to composition 7 days to last to after composition 1
Week, daily observed and recorded 1 time；Wherein heart rate and pupil are measured 1 time for every 2 days, and body weight claims weekly 1 time.
Electrocardiographic examination：Rabbit is derived from right erect position, traces II lead, is traced 2 times to 7 days before composition, after composition
Trace 1 time within every 3 weeks.
Blood blood examination is looked into：Extracting vein blood, red, leucocyte and quantitative blood red egg are counted with Couter blood counts (Britain's production)
In vain；With general microscopic counting blood platelet and leukocyte differential count.To 2 weeks before composition, per weekly check 1 time；To after composition every 3
Weekly check 1 time.
Blood biochemistry checking：Venous blood sampling, anticoagulant heparin, separated plasma；Surveyed with automatic biochemical analyzer (Corona, Sweden's production)
Determine glutamic-pyruvic transaminase (GPT) and creatinine (CRTN), urea nitrogen (BUN) and sulfobromophthalein sodium (BSP) are determined with laboratory conventional method
Retention rate；The same hematological examination of sampling and measuring time.
Uroscopy：The red matter of urine pH, albumen, glucose, ketoboidies, UBG, courage of rabbit is checked with urine test paper and is dived
Blood etc., microscopy cast, RBC and WBC etc., time of taking a sample to check same hematological examination.
System postmortem：3 are killed to every group of each work of animal in 24 hours after composition in last, other rabbit lasts are to composition
Live again within 1 week afterwards and enter row system postmortem.
Histological examination：Divide 2 batches, every batch every group each 5 are checked (time homologous ray postmortem).The scope of examination includes
Brain, the heart, lung, liver, kidney, adrenal gland, spleen, stomach, jejunum, pancreas and testis (hero).
Convalescence checks：Convalescence, its detection content was identical with to the composition phase in addition to test composition is not given.
(3) result of the test
Overview：Do not occur obvious dry (mycteroxerosis and oral cavity secretion to each group animal after composition 2~3 weeks
Thing is few), Nausea and vomiting and anorexia (feed is reduced)；Activity and behavior and fecal character are had no significant effect；Body weight：
Body weight is without obvious change before and after each group animal composition；Pupil：Each group animal does not have obvious expansion pupil phenomenon；Heart rate：Each group
The equal no significant difference of animal changes in heart rate；Electrocardiogram：Each group animal is to the electrocardiogram after composition, except early stage has stopping up property heart rate to add
It is fast outer, substantially change without other；Blood biochemical：Each group animal is to GPT, BSP retention rate, the blood urea nitrogen (BUN) after composition
(BUN) change with creatinine without obvious, show to have no significant effect hepatic and renal function；Hematology：After each group animal is to composition
RBC and WBC sums, Hb, blood platelet and leukocyte differential count have no significant change；Urine：Each group animal is to the urine after composition
The red matter of pH, albumen, glucose, ketoboidies, courage and occult blood and microscopy finding, and to before composition and blank control group compares,
Without substantially change；System postmortem：After to composition 12 weeks and stop composition after 1 week the living blank control group killed implement with each
Example group animal, system postmortem no significant difference, also no abnormality seen changes each group；Histological examination：After each group animal is to composition
12 weeks and after stopping composition 1 week, the pathological change relevant with composition toxicity, and blank pair are not found in 11 kinds of internal organs such as brain
According to a group no significant difference.Conclusion：As a result all animals are shown to composition 12 weeks and after stopping composition 1 week, urine, hematology with
Blood biochemical analysis inspection, system postmortem and histological examination have no significant change.Show the present invention prepare have intelligence development
The composition security for encouraging effect is credible.
2nd, the effect that children are encouraged
The object of observation：450 10~12 years old children；450 children are divided into nine groups at random, one group normal
Outside diet (control group), other group of normal diet, respectively before breakfast, lunch each edible 50g embodiment of the present invention one to implementation
The composition that example six, comparative example one are prepared to comparative example two；It is continuous edible 3 months.
Observation index：Observe ordinary circumstance and height and body weight.
Observe result：400 take the composition that the embodiment of the present invention one is prepared to embodiment six children
Have no any adverse reaction, after taking appetite increase, being full of animal spirits, have rosy cheeks, sleep stable, hypermnesia, disease
Reduce, illustrate that the composition that the present invention is provided can promote the growth and intelligence development of children, build up health, nothing is appointed after taking
What side effect.Shown in the result of variations table 1 specific as follows of height and body weight.
The situation of change of the height of table 1 and body weight
| Group | Height increases average value (cm) | Body weight increase average value (kg) |
| Control group | 2.54 | 0.68 |
| Embodiment one | 2.97 | 1.03 |
| Embodiment two | 2.89 | 0.96 |
| Embodiment three | 3.01 | 1.05 |
| Example IV | 4.23 | 1.41 |
| Embodiment five | 4.26 | 1.39 |
| Embodiment six | 4.37 | 1.43 |
| Comparative example one | 2.85 | 0.94 |
| Comparative example two | 2.61 | 0.92 |
Individual example explanation：Outside Zhang, 10 years old boy, normal diet, the embodiment of the present invention six is eaten before breakfast, lunch respectively
The composition 50g that there is intelligence development to encourage effect provided, eats one month, height increases 2cm；Said composition is not eaten, normally
Diet one month, height only increases by 7~8mm.
3rd, the brain tonic and intelligence development effect (big white mouse study, memory) of composition
Test method：Healthy SD bull big white mouse 100 is chosen, 180~220g of body weight is raised at room temperature, drink is certainly
Water, eats standard feed.100 big white mouse are randomly divided into ten groups, including：Blank control group, piracetam group (experiment contrast
Group, 2-Pyrrolidone acetamide), one group of embodiment to six groups of embodiment, one group of comparative example to two groups, every group 10 of comparative example.
Blank control group：With 0.1ml/10g/ gavage of 0.9% physiological saline, 3 times/day；Piracetam group (experimental comparison group)：With 10%
0.03ml/10g/ gavage of piracetam solution, 3 times/day；One group of embodiment is to six groups of embodiment, one group of comparative example to comparative example
Two groups (experimental group)：The combination prepared respectively with the embodiment of the present invention one to embodiment six, comparative example one to comparative example two
Thing (is well mixed) 0.1g/10g/ gavage, 3 times/day, common gavage 10 days after using preceding all crushing.
By above-mentioned ten groups of rats respectively at the learning training that labyrinth is carried out after gavage 10 days.Experiment is entered in quiet environment
OK, rat is put into labyrinth during experiment and first adapted to 5 minutes, then start experiment, the support arm for having light is place of safety no power,
Place of safety is with random order conversions, and power-on voltage is 30~50V.It is " correct that rat, which directly escapes after being shocked by electricity to place of safety person,
Reaction ", otherwise belongs to " wrong reaction ".There are 9 correct responses to calculate the standard for reaching association continuous 10 times.
Observation index：(1) number of times of reaction needed for reaching before association's standard：Required number of times is fewer, and learning and memory is better；
(2) during overall reaction campaign：Refer to and add up each secondary response, since escaping to be taken untill the bright place of safety of lamp to big white mouse signal lamp is bright
Between summation；(3) active avoidance response rate：The number of times that rat completed reaction in 5 seconds accounts for the percentage of overall reaction number of times；(4)
Correct response rate：Refer to the percentage that " correct response " number of times accounts for overall reaction number of times.
Experimental result：Piracetam is the known medicine for promoting memory, and this experiment finds that composition can make big white mouse labyrinth
Learn number of times and correct response rate is improved, illustrate that the medicine plays the role of to promote big white mouse study, memory.After medication, experimental group
Compared with blank control group, reach that reaction times are reduced before standard, correct response rate is improved, and experimental group active avoidance rate is more
Height, concrete outcome is as shown in Table 2 below.
The different group big white mouse reactions change situations of table 2
It should be noted that situation about being enumerated to embodiment six except above-described embodiment one, is matched somebody with somebody from other raw material components
Than and preparation method thereof parameter be also feasible.
The technical scheme that the present invention is provided, with following beneficial effect：(1) composition that provides of the present invention, from containing
There are the raw-food material and Chinese medicinal material of active skull cap components, prescription proportioning science, without any Western medicine hormonal components, safe nothing
Toxic side effect, with the growth and intelligence development for promoting children, can slow down the amnesia and insomnia of palpitating with fear of the elderly
Effect；(2) preparation method for the composition that the present invention is provided, each raw material active component can be retained to greatest extent, so that
Make the composition finally prepared, not only with good effect, and be easy to absorb；(3) composition that the present invention is provided
Preparation method is simple, and production cost is low.
It should be noted that unless otherwise indicated, technical term or scientific terminology used in this application should be this hair
The ordinary meaning that bright one of ordinary skill in the art are understood.Unless specifically stated otherwise, otherwise illustrate in these embodiments
Part and relative step, numerical expression and the numerical value of step are not limit the scope of the invention.It is illustrated and described herein
In all examples, unless otherwise prescribed, any occurrence should be construed as merely exemplary, not as limitation, because
This, other examples of exemplary embodiment can have different values.
Finally it should be noted that：Various embodiments above is merely illustrative of the technical solution of the present invention, rather than its limitations；To the greatest extent
The present invention is described in detail with reference to foregoing embodiments for pipe, it will be understood by those within the art that：Its according to
The technical scheme described in foregoing embodiments can so be modified, or which part or all technical characteristic are entered
Row equivalent substitution；And these modifications or replacement, the essence of appropriate technical solution is departed from various embodiments of the present invention technology
The scope of scheme, it all should cover among protection scope of the present invention.
Claims (10)
1. a kind of encourage the composition of effect with intelligence development, it is characterised in that the raw material components of the composition by weight,
Including：
The parts by weight of meat 40~50, the parts by weight of fennel 2~5, the parts by weight of cassia bark 3~6, the parts by weight of capsicum 1~3, the weight of garlic 2~4
Part, the parts by weight of ginger 4~6, the parts by weight of mushroom 10~15, the parts by weight of hawthorn 5~10, the parts by weight of celery 8~12, balsam pear 7~11
Parts by weight, the parts by weight of jujube 5~10, the parts by weight of carrot 10~15, the parts by weight of walnut kernel 15~25 and the weight of cashew nut kernel 10~15
Part.
2. the composition according to claim 1 that effect is encouraged with intelligence development, it is characterised in that：
One or more of the meat in pork, beef, mutton, chicken and duck.
3. the composition according to claim 2 that effect is encouraged with intelligence development, it is characterised in that
The raw material components of the composition also include the parts by weight of Chinese medical extract 20~30, the raw material components of the Chinese medical extract
By weight, including：The parts by weight of ginseng 10~12, the parts by weight of rhizoma Gastrodiae 15~20, the parts by weight of the Radix Astragali 3~8, the weight of matrimony vine 4~6
Part, the parts by weight of the coptis 2~5, the parts by weight of radix bupleuri 7~10, the parts by weight of the root of kudzu vine 13~15, the parts by weight of Poria cocos 8~10, the weight of the bighead atractylodes rhizome 3~6
Measure part, windproof 5~9 parts by weight, the parts by weight of dried orange peel 3~7, the parts by weight of Ligusticum wallichii 1~4, the parts by weight of Radix Angelicae Sinensis 6~10, the weight of folium artemisiae argyi 8~12
Measure part, the parts by weight of the red sage root 7~10, the parts by weight of Fructus meliae toosendan 5~15, the parts by weight of pseudo-ginseng 5~10, the parts by weight of ganoderma lucidum 2~4 and the stem of noble dendrobium 3
~5 parts by weight.
4. the composition according to claim 3 that effect is encouraged with intelligence development, it is characterised in that the Chinese medical extract
Preparation method, comprises the following steps：
S101：All raw material components are put into ethanol water, heats, then filters after immersion, filtrate and filter are collected respectively
Slag；
S102：The filter residue is subjected to refluxing extraction, then filtered, filtrate is collected；
S103：The S101 filtrates collected and the S102 filtrate collected are merged, reduction vaporization concentration is then carried out, obtains
To concentrate；
S104：By the concentrate drying to constant weight, the Chinese medical extract is obtained.
5. the composition according to claim 4 that effect is encouraged with intelligence development, it is characterised in that：
In the S101, the ratio of the quality of the ethanol water and the gross mass of all raw material components is (15~20):1,
The volume fraction of the ethanol water is 40%~50%；The time of the immersion is 8~10h；The temperature of the heating is
85~95 DEG C, the time of the heating is 80~100min.
6. the composition according to claim 4 that effect is encouraged with intelligence development, it is characterised in that：
In the S102, in the refluxing extraction, extract solution is the ethanol water of volume fraction 50%~60%, the extraction
The ratio of the volume of liquid and the quality of the filter residue is (10~20) mL:1g.
7. the composition according to claim 4 that effect is encouraged with intelligence development, it is characterised in that：
In the S103, the temperature that concentration is evaporated under reduced pressure is 40~50 DEG C, the pressure that concentration is evaporated under reduced pressure for 65~
70mmHg, the Baume degrees of the concentrate is 1.2~1.3.
8. the composition according to claim 4 that effect is encouraged with intelligence development, it is characterised in that：
In the S104, the drying is spray drying, wherein：EAT is 100~120 DEG C, and leaving air temp is 50~60
DEG C, feed rate is 10~20mL/min.
9. the preparation method of the composition that effect is encouraged with intelligence development described in claim any one of 1-8, it is characterised in that bag
Include following steps：
S1：By the chopping of meat, mushroom, hawthorn, celery, balsam pear, jujube, ginger and carrot, then with fennel, cassia bark, capsicum, big
Garlic is well mixed, and is then placed in heater and is heated；
S2：Other raw material components are crushed, the product then obtained with the S1 is well mixed, encapsulation sterilizing obtains described group
Compound.
10. the preparation method of the composition according to claim 9 that effect is encouraged with intelligence development, it is characterised in that：
In the S1, the temperature adjustment of the heater includes：It is down to from 20~30 DEG C of heating rates with 2~5 DEG C/min
55~60 DEG C, it is incubated 60~70min；Then 120~140 DEG C are risen to 1.5~2.5 DEG C/min heating rate, insulation 30~
40min；Then 20~30 DEG C are down to 1~2 DEG C/min rate of temperature fall.
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Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1083674A (en) * | 1993-01-01 | 1994-03-16 | 英兆和 | High-energy healthy ginger food and preparation method thereof |
| CN1423963A (en) * | 2002-12-19 | 2003-06-18 | 蔺建民 | Healthy instant food |
| CN103005499A (en) * | 2012-12-03 | 2013-04-03 | 安徽光正食品有限公司 | Processing method of mushroom fragrance beef and mushroom fragrance beef |
| CN103564293A (en) * | 2013-10-16 | 2014-02-12 | 青岛金佳慧食品有限公司 | Health food for preventing and treating senile dementia |
| CN106473099A (en) * | 2016-10-12 | 2017-03-08 | 钟术光 | Functional food or alternative tea that effect improves |
-
2017
- 2017-05-18 CN CN201710354014.7A patent/CN107212406A/en active Pending
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1083674A (en) * | 1993-01-01 | 1994-03-16 | 英兆和 | High-energy healthy ginger food and preparation method thereof |
| CN1423963A (en) * | 2002-12-19 | 2003-06-18 | 蔺建民 | Healthy instant food |
| CN103005499A (en) * | 2012-12-03 | 2013-04-03 | 安徽光正食品有限公司 | Processing method of mushroom fragrance beef and mushroom fragrance beef |
| CN103564293A (en) * | 2013-10-16 | 2014-02-12 | 青岛金佳慧食品有限公司 | Health food for preventing and treating senile dementia |
| CN106473099A (en) * | 2016-10-12 | 2017-03-08 | 钟术光 | Functional food or alternative tea that effect improves |
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Application publication date: 20170929 |