CN107184409A - 一种促睡眠功效的褪黑激素缓释鼻腔保健香水及制作方法 - Google Patents
一种促睡眠功效的褪黑激素缓释鼻腔保健香水及制作方法 Download PDFInfo
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Abstract
本发明公开了一种促睡眠功效的褪黑激素缓释鼻腔保健香水及制作方法,所述保健香水是采用多组原料制备而成，原料组成质量配比为：褪黑激素0.1%‑3%、具有鼻腔保健功效的中药添加物1%‑5%、檀香混合香精0.1%‑0.5%、防腐剂0.1%‑0.3%和适量的可药用辅料，其余为缓释辅料，本发明利用褪黑激素具有促睡眠的功效，并辅以鼻腔保健的天然功效添加物，以香水的形式扩散至空气中，通过呼吸道鼻腔吸入可绕过血脑屏障直接进入中枢，并通过缓释处理，确保在使用2‑4小时达到最大释放量，使中枢的褪黑激素浓度呈现高生理需求的变化，并辅以不同香型香精，改善睡眠环境，从而达到促进睡眠并辅以鼻腔保健的效果，且方便携带，安全无毒，无刺激性的优势。
Description
技术领域
本发明涉及化妆品技术领域，具体为一种促睡眠功效的褪黑激素缓释鼻腔保健香水及制作方法。
背景技术
香水除了增加魅力的作用之外，是否还能具有额外的作用，人们做了大量的研究，目前市场上的香水大部分使用化学香料配置而成，这些化学香料含有芳香族苯环化合物，伴随酒精挥发出来，对人体器官特别是呼吸系统产生刺激，对接触者会出现咳嗽、头晕、呕吐等症状，有害身体健康。如果长期使用，还可能会造成嗅觉迟钝、视力减弱，甚至成为致癌诱因。同时，一些劣质香水还含有让香味持久的磷苯二甲酸酯，这种化学物质会导致精子活动力变低、乃至死亡，目前已经成为导致男性精子死亡的一大杀手。此外，这类香水的用途比较单一，即单纯强调其气味而不注重其他功效，因此，也限制了其应用范围。
所以，如何设计一种具有促睡眠功效的褪黑激素缓释鼻腔保健香水及制作方法，成为我们当前要解决的问题。
发明内容
本发明的目的在于提供一种促睡眠功效的褪黑激素缓释鼻腔保健香水及制作方法，利用褪黑激素具有促睡眠的功效，并辅以鼻腔保健的天然功效添加物，以香水的形式扩散至空气中，通过呼吸道鼻腔吸入可绕过血脑屏障直接进入中枢，并通过缓释处理，确保在使用2-4小时达到最大释放量，使中枢的褪黑激素浓度呈现高生理需求的变化，并辅以不同香型香精，改善睡眠环境，从而达到促进睡眠并辅以鼻腔保健的效果，且方便携带，安全无毒，无刺激性的优势，以解决上述背景技术中提出的问题。
为实现上述目的，本发明提供如下技术方案：
一种促睡眠功效的褪黑激素缓释鼻腔保健香水，所述保健香水是采用多组原料制备而成，原料组成质量配比为：
褪黑激素0.1%-3%、具有鼻腔保健功效的中药添加物1%-5%、檀香混合香精0.1%-0.5%、防腐剂0.1%-0.3%和适量的可药用辅料，其余为缓释辅料。
根据上述技术方案，所述褪黑激素可以辅以不同香型香精。
根据上述技术方案，所述具有鼻腔保健功效的中药添加物包括辛夷提取物、苍耳子提取物、野菊花提取物、藿香提取物其中的一种或几种组合物。
根据上述技术方案，所述檀香混合香精包括薰衣草香精、柠檬香精、茉莉香精、玫瑰香精、蔷薇香精、含羞草香精、桉油香精、兰花香精、迷迭香香精、积雪草香精其中的一种或几种组合物，与檀香粉经冷冻-微波解冻后蒸馏所得的檀香混合香精。
根据上述技术方案，所述防腐剂不影响药物的理化性质、且在抑菌浓度下对人体无害、无刺激性和特殊的臭味的试剂，包括尼泊金甲酯、尼泊金乙酯、尼泊金丙酯、尼泊金丁酯、羟苯乙酯、山梨酸钾、苯甲酸其中的一种或几种组合物。
根据上述技术方案，所述可药用辅料包括壳聚糖、环糊精、明胶。
一种促睡眠功效的褪黑激素缓释鼻腔保健香水制作方法，包括如下步骤：
（1）制备褪黑素微球：将100g充分溶胀的25%明胶溶液加热至50℃为透明澄清溶液，加入10g褪黑激素，经10000rpm的乳化机剪切20-30s，加入100g50℃预热的溶胀过夜的2.5%醋酸壳聚糖溶液，水浴锅中400rpm搅拌15min；保持温度为50℃下，提高转述至500rpm持续反应30min，冷水浴将体系缓慢降温至20℃，加入5%戊二醛溶液25mL，5min后转移至水浴锅内将固化温度设定为30℃去微囊表面残留的戊二醛，干燥得粉末状即得；
（2）制备檀香混合香精：将薰衣草香精、柠檬香精、茉莉香精、玫瑰香精、蔷薇香精、含羞草香精、桉油香精、兰花香精、迷迭香香精、积雪草香精其中的一种或几种组合物在低温下，与乙醇混合得到原始香水，作为提取剂，称取檀香木粉，立即放入负85℃的冰箱中，冷冻4h-6h；冻结后将其从冰箱中取出，进行微波加热25S，随后放入至挥发油提取器中，常压水蒸气蒸馏3h-3.5h，得具有特殊气味的混合檀香香精，备用；
（3）制备成品香水：取0.1%-3%褪黑素微球、1%-5%具有鼻腔保健功效的中药添加物1%-5%、0.1%-0.5%檀香混合香精、0.1%-0.3%防腐剂、适量的可药用辅料和缓释辅料，加入到溶剂中进行溶解，搅拌混合均匀，过滤，灌装加盖密封即得成品保健香水。
根据上述技术方案，所述制备檀香混合香精中中檀香木粉：提取剂为1:0.8-1.5。
与现有技术相比，本发明的有益效果是：
1）褪黑激素首次应用在促睡眠香水配方开发中，褪黑激素是人类松果体分泌产生的一种吲哚类激素，为内源性的物质，通过对内分泌系统的调节而起作用，对机体来说并非异物，具有促进睡眠、延缓衰老、增强免疫和抗肿瘤等作用；
2）褪黑素的作用靶点在中枢，鼻腔给药的优点是经鼻腔吸收后可直接进入中枢，绕过了血脑屏障，生物利用度大幅度提高，鼻腔吸收给药量仅为口服剂量的约百分之一，这一途径给药也可避免较高剂量口服褪黑素带来的次日嗜睡等副作用；褪黑素吸入后经肺泡吸收还是进外周血液系统，与口服给药比较无明显优势；
3）首次通过调节睡眠节律性，褪黑素的活性作用应表述为“助睡眠”；褪黑素为内源性物质，其较好的给药效果为，补充的褪黑素与体内褪黑素浓度的变化周期一致，即每天凌晨两点在中枢系统达到峰值，其他时间褪黑素的浓度很低，外周褪黑素的浓度也应很低；从时效性上评价，具有很强的节律性，而非“速效”，实现按生理周期中枢，区域选择性给药的效果，有益睡眠保健；
4）首次通过香水的方式，使用极方便；利用空气扩散鼻腔粘膜吸收，调节大脑皮质功能和植物神经功能系统，从而达到镇静安神、改善睡眠的保健功能，达到鼻腔保健的目的；
5）安全可靠、保健效果好：本发明配方中所用主要成分为内源性的物质，对机体来说并非异物，无毒、无刺激性、无致敏性、在体内有其自身的代谢途径，不会造成母药及其代谢物在体内蓄积、无成瘾性，克服使用者对内服药物的恐惧心理；促进入睡、镇静安神和改善睡眠质量，对睡眠不佳者，还有预防保健作用；
6）将微球技术应用在香水制作工艺，通过空气扩散鼻腔吸收，有很强的生物黏附性，同时有效成分在鼻腔部位的滞留时间可延长至４小时；此外，微球剂还能保护药物不受酶的代谢，因此在很大程度上提高了药物的生物利用度；
7）运用冷冻-微波精馏法提取檀香混合香精应用于产业化，制备复合功效香精。
附图说明
图1是本发明的制备流程图。
具体实施方式
下面将结合本发明实施例中的附图，对本发明实施例中的技术方案进行清楚、完整地描述，显然，所描述的实施例仅仅是本发明一部分实施例，而不是全部的实施例。基于本发明中的实施例，本领域普通技术人员在没有做出创造性劳动前提下所获得的所有其他实施例，都属于本发明保护的范围。
请参阅图1，本发明提供根据上述技术方案，一种促睡眠功效的褪黑激素缓释鼻腔保健香水，所述保健香水是采用多组原料制备而成，原料组成质量配比为：
褪黑激素0.1%-3%、具有鼻腔保健功效的中药添加物1%-5%、檀香混合香精0.1%-0.5%、防腐剂0.1%-0.3%和适量的可药用辅料，其余为缓释辅料。
根据上述技术方案，所述褪黑激素可以辅以不同香型香精。
根据上述技术方案，所述具有鼻腔保健功效的中药添加物包括辛夷提取物、苍耳子提取物、野菊花提取物、藿香提取物其中的一种或几种组合物。
根据上述技术方案，所述檀香混合香精包括薰衣草香精、柠檬香精、茉莉香精、玫瑰香精、蔷薇香精、含羞草香精、桉油香精、兰花香精、迷迭香香精、积雪草香精其中的一种或几种组合物，与檀香粉经冷冻-微波解冻后蒸馏所得的檀香混合香精。
根据上述技术方案，所述防腐剂不影响药物的理化性质、且在抑菌浓度下对人体无害、无刺激性和特殊的臭味的试剂，包括尼泊金甲酯、尼泊金乙酯、尼泊金丙酯、尼泊金丁酯、羟苯乙酯、山梨酸钾、苯甲酸其中的一种或几种组合物。
根据上述技术方案，所述可药用辅料包括壳聚糖、环糊精、明胶。
一种促睡眠功效的褪黑激素缓释鼻腔保健香水制作方法，包括如下步骤：
（1）制备褪黑素微球：将100g充分溶胀的25%明胶溶液加热至50℃为透明澄清溶液，加入10g褪黑激素，经10000rpm的乳化机剪切20-30s，加入100g50℃预热的溶胀过夜的2.5%醋酸壳聚糖溶液，水浴锅中400rpm搅拌15min；保持温度为50℃下，提高转述至500rpm持续反应30min，冷水浴将体系缓慢降温至20℃，加入5%戊二醛溶液25mL，5min后转移至水浴锅内将固化温度设定为30℃去微囊表面残留的戊二醛，干燥得粉末状即得；
（2）制备檀香混合香精：将薰衣草香精、柠檬香精、茉莉香精、玫瑰香精、蔷薇香精、含羞草香精、桉油香精、兰花香精、迷迭香香精、积雪草香精其中的一种或几种组合物在低温下，与乙醇混合得到原始香水，作为提取剂，称取檀香木粉，立即放入负85℃的冰箱中，冷冻4h-6h；冻结后将其从冰箱中取出，进行微波加热25S，随后放入至挥发油提取器中，常压水蒸气蒸馏3h-3.5h，得具有特殊气味的混合檀香香精，备用；
（3）制备成品香水：取0.1%-3%褪黑素微球、1%-5%具有鼻腔保健功效的中药添加物1%-5%、0.1%-0.5%檀香混合香精、0.1%-0.3%防腐剂、适量的可药用辅料和缓释辅料，加入到溶剂中进行溶解，搅拌混合均匀，过滤，灌装加盖密封即得成品保健香水。
根据上述技术方案，所述制备檀香混合香精中中檀香木粉：提取剂为1:0.8-1.5。
基于上述，本发明的优点在于，褪黑激素首次应用在促睡眠香水配方开发中，褪黑激素是人类松果体分泌产生的一种吲哚类激素，为内源性的物质，通过对内分泌系统的调节而起作用，对机体来说并非异物，具有促进睡眠、延缓衰老、增强免疫和抗肿瘤等作用；褪黑素的作用靶点在中枢，鼻腔给药的优点是经鼻腔吸收后可直接进入中枢，绕过了血脑屏障，生物利用度大幅度提高，鼻腔吸收给药量仅为口服剂量的约百分之一，这一途径给药也可避免较高剂量口服褪黑素带来的次日嗜睡等副作用；褪黑素吸入后经肺泡吸收还是进外周血液系统，与口服给药比较无明显优势；首次通过调节睡眠节律性，褪黑素的活性作用应表述为“助睡眠”；褪黑素为内源性物质，其较好的给药效果为，补充的褪黑素与体内褪黑素浓度的变化周期一致，即每天凌晨两点在中枢系统达到峰值，其他时间褪黑素的浓度很低，外周褪黑素的浓度也应很低；从时效性上评价，具有很强的节律性，而非“速效”，实现按生理周期中枢，区域选择性给药的效果，有益睡眠保健；首次通过香水的方式，使用极方便；利用空气扩散鼻腔粘膜吸收，调节大脑皮质功能和植物神经功能系统，从而达到镇静安神、改善睡眠的保健功能，达到鼻腔保健的目的；安全可靠、保健效果好：本发明配方中所用主要成分为内源性的物质，对机体来说并非异物，无毒、无刺激性、无致敏性、在体内有其自身的代谢途径，不会造成母药及其代谢物在体内蓄积、无成瘾性，克服使用者对内服药物的恐惧心理；促进入睡、镇静安神和改善睡眠质量，对睡眠不佳者，还有预防保健作用；将微球技术应用在香水制作工艺，通过空气扩散鼻腔吸收，有很强的生物黏附性，同时有效成分在鼻腔部位的滞留时间可延长至４小时；此外，微球剂还能保护药物不受酶的代谢，因此在很大程度上提高了药物的生物利用度；运用冷冻-微波精馏法提取檀香混合香精应用于产业化，制备复合功效香精。
尽管已经示出和描述了本发明的实施例，对于本领域的普通技术人员而言，可以理解在不脱离本发明的原理和精神的情况下可以对这些实施例进行多种变化、修改、替换和变型，本发明的范围由所附权利要求及其等同物限定。
Claims (8)
1.一种促睡眠功效的褪黑激素缓释鼻腔保健香水，其特征在于：所述保健香水是采用多组原料制备而成，原料组成质量配比为：褪黑激素0.1%-3%、具有鼻腔保健功效的中药添加物1%-5%、檀香混合香精0.1%-0.5%、防腐剂0.1%-0.3%和适量的可药用辅料，其余为缓释辅料。
2.根据权利要求1所述的一种促睡眠功效的褪黑激素缓释鼻腔保健香水，其特征在于：所述褪黑激素可以辅以不同香型香精。
3.根据权利要求1所述的一种促睡眠功效的褪黑激素缓释鼻腔保健香水，其特征在于：所述具有鼻腔保健功效的中药添加物包括辛夷提取物、苍耳子提取物、野菊花提取物、藿香提取物其中的一种或几种组合物。
4.根据权利要求1所述的一种促睡眠功效的褪黑激素缓释鼻腔保健香水，其特征在于：所述檀香混合香精包括薰衣草香精、柠檬香精、茉莉香精、玫瑰香精、蔷薇香精、含羞草香精、桉油香精、兰花香精、迷迭香香精、积雪草香精其中的一种或几种组合物，与檀香粉经冷冻-微波解冻后蒸馏所得的檀香混合香精。
5.根据权利要求1所述的一种促睡眠功效的褪黑激素缓释鼻腔保健香水，其特征在于：所述防腐剂不影响药物的理化性质、且在抑菌浓度下对人体无害、无刺激性和特殊的臭味的试剂，包括尼泊金甲酯、尼泊金乙酯、尼泊金丙酯、尼泊金丁酯、羟苯乙酯、山梨酸钾、苯甲酸其中的一种或几种组合物。
6.根据权利要求1所述的一种促睡眠功效的褪黑激素缓释鼻腔保健香水，其特征在于：所述可药用辅料包括壳聚糖、环糊精、明胶。
7.一种促睡眠功效的褪黑激素缓释鼻腔保健香水制作方法，其特征在于：包括如下步骤：
（1）制备褪黑素微球：将100g充分溶胀的25%明胶溶液加热至50℃为透明澄清溶液，加入10g褪黑激素，经10000rpm的乳化机剪切20-30s，加入100g50℃预热的溶胀过夜的2.5%醋酸壳聚糖溶液，水浴锅中400rpm搅拌15min；保持温度为50℃下，提高转述至500rpm持续反应30min，冷水浴将体系缓慢降温至20℃，加入5%戊二醛溶液25mL，5min后转移至水浴锅内将固化温度设定为30℃去微囊表面残留的戊二醛，干燥得粉末状即得；
（2）制备檀香混合香精：将薰衣草香精、柠檬香精、茉莉香精、玫瑰香精、蔷薇香精、含羞草香精、桉油香精、兰花香精、迷迭香香精、积雪草香精其中的一种或几种组合物在低温下，与乙醇混合得到原始香水，作为提取剂，称取檀香木粉，立即放入负85℃的冰箱中，冷冻4h-6h；冻结后将其从冰箱中取出，进行微波加热25S，随后放入至挥发油提取器中，常压水蒸气蒸馏3h-3.5h，得具有特殊气味的混合檀香香精，备用；
（3）制备成品香水：取0.1%-3%褪黑素微球、1%-5%具有鼻腔保健功效的中药添加物1%-5%、0.1%-0.5%檀香混合香精、0.1%-0.3%防腐剂、适量的可药用辅料和缓释辅料，加入到溶剂中进行溶解，搅拌混合均匀，过滤，灌装加盖密封即得成品保健香水。
8.根据权利要求7所述的一种促睡眠功效的褪黑激素缓释鼻腔保健香水制作方法，其特征在于：所述制备檀香混合香精中中檀香木粉：提取剂为1:0.8-1.5。
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