CN107158564A - A kind of external diaphragm pacemaker of the medium frequency electric stimulation of low frequency modulations - Google Patents
A kind of external diaphragm pacemaker of the medium frequency electric stimulation of low frequency modulations Download PDFInfo
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- 230000000638 stimulation Effects 0.000 title claims abstract description 31
- 230000003321 amplification Effects 0.000 claims abstract description 25
- 238000003199 nucleic acid amplification method Methods 0.000 claims abstract description 25
- 239000003990 capacitor Substances 0.000 claims description 33
- 230000005611 electricity Effects 0.000 claims description 13
- 238000004804 winding Methods 0.000 claims description 9
- 238000006243 chemical reaction Methods 0.000 claims description 2
- 241001274660 Modulus Species 0.000 claims 1
- 230000008859 change Effects 0.000 abstract description 7
- 238000000338 in vitro Methods 0.000 abstract description 5
- 238000000108 ultra-filtration Methods 0.000 abstract description 5
- 230000001225 therapeutic effect Effects 0.000 abstract description 4
- 238000001827 electrotherapy Methods 0.000 description 10
- 230000000694 effects Effects 0.000 description 8
- 238000010586 diagram Methods 0.000 description 6
- 210000001519 tissue Anatomy 0.000 description 6
- 230000008602 contraction Effects 0.000 description 5
- 210000003205 muscle Anatomy 0.000 description 5
- 238000005868 electrolysis reaction Methods 0.000 description 4
- 238000000034 method Methods 0.000 description 4
- 230000033001 locomotion Effects 0.000 description 3
- 210000005036 nerve Anatomy 0.000 description 3
- 230000000241 respiratory effect Effects 0.000 description 3
- 230000029058 respiratory gaseous exchange Effects 0.000 description 3
- 230000035807 sensation Effects 0.000 description 3
- CDBYLPFSWZWCQE-UHFFFAOYSA-L Sodium Carbonate Chemical compound [Na+].[Na+].[O-]C([O-])=O CDBYLPFSWZWCQE-UHFFFAOYSA-L 0.000 description 2
- 239000002253 acid Substances 0.000 description 2
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 2
- 230000008901 benefit Effects 0.000 description 2
- 201000010099 disease Diseases 0.000 description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
- 230000006870 function Effects 0.000 description 2
- 210000000876 intercostal muscle Anatomy 0.000 description 2
- 230000003902 lesion Effects 0.000 description 2
- 238000012544 monitoring process Methods 0.000 description 2
- 230000004118 muscle contraction Effects 0.000 description 2
- 229910052760 oxygen Inorganic materials 0.000 description 2
- 239000001301 oxygen Substances 0.000 description 2
- 230000002093 peripheral effect Effects 0.000 description 2
- 238000005424 photoluminescence Methods 0.000 description 2
- 238000011084 recovery Methods 0.000 description 2
- 230000001953 sensory effect Effects 0.000 description 2
- 238000002560 therapeutic procedure Methods 0.000 description 2
- 210000000115 thoracic cavity Anatomy 0.000 description 2
- 208000003417 Central Sleep Apnea Diseases 0.000 description 1
- 208000010476 Respiratory Paralysis Diseases 0.000 description 1
- 210000003489 abdominal muscle Anatomy 0.000 description 1
- 230000000202 analgesic effect Effects 0.000 description 1
- 210000000467 autonomic pathway Anatomy 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000002146 bilateral effect Effects 0.000 description 1
- 230000005540 biological transmission Effects 0.000 description 1
- 210000000133 brain stem Anatomy 0.000 description 1
- 230000002925 chemical effect Effects 0.000 description 1
- 230000001684 chronic effect Effects 0.000 description 1
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- 238000005516 engineering process Methods 0.000 description 1
- 238000002513 implantation Methods 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- 230000003434 inspiratory effect Effects 0.000 description 1
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- 239000000203 mixture Substances 0.000 description 1
- 230000007383 nerve stimulation Effects 0.000 description 1
- 210000000062 pectoralis major Anatomy 0.000 description 1
- 230000000704 physical effect Effects 0.000 description 1
- 230000035479 physiological effects, processes and functions Effects 0.000 description 1
- 230000036647 reaction Effects 0.000 description 1
- 230000004202 respiratory function Effects 0.000 description 1
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- 230000033764 rhythmic process Effects 0.000 description 1
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
- A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
- A61N1/36014—External stimulators, e.g. with patch electrodes
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
- A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
- A61N1/3601—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation of respiratory organs
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Abstract
The invention discloses a kind of external diaphragm pacemaker of the medium frequency electric stimulation of low frequency modulations, it includes low frequency modulations circuit, amount of bias adjustment circuit, voltage amplitude adjustment circuit, power amplification circuit and isolating transformer, the low frequency modulations circuit is modulated the offset signal that the analog signal to be formed produces with amount of bias adjustment circuit to low frequency signal and is overlapped, and the signal after superposition is adjusted via voltage amplitude adjustment circuit to voltage amplitude successively, power amplification circuit carries out passing through isolating transformer output treatment signal after power amplification again.The present invention is superimposed by low frequency modulations, amount of bias, voltage amplitude is adjusted, power amplification and isolating transformer cause its output result to change with the change of the frequency and amplitude of low frequency signal, the characteristics of with low frequency, electric current of intermediate frequency and therapeutic action, the intermediate frequency electro ultrafiltration of low frequency modulations is deeper, it is more suitable for the deeper patient of the in vitro table of the stimulation to nervus phrenicus, particularly nervus phrenicus.
Description
Technical field
The invention belongs to medical instruments field, and in particular in the low frequency modulations in the physiatrics of medical science of recovery therapy field
The external diaphragm pacemaker of frequency electro photoluminescence.
Background technology
The breathing related muscles of human body mainly have diaphram, external intercostal muscles, pectoralis major, abdominal muscle, nutator etc., its middle diaphragm
Flesh and external intercostal muscles are topmost inspiratory muscles.During air-breathing, contraction of diaphragm, under diaphragm top will, thoracic cavity increase；During expiration, diaphram relaxes
, diaphragm top rises, and thoracic cavity reduces.Diaphram is topmost respiratory muscle, and in normal respiration, the effect of contraction of diaphragm accounts for throughput
70% to 80%, but diaphram oxygen demand is seldom, is generally less than the 20% of whole breathing muscle group oxygen demand.From angle of physiology
See, it is that respiratory movement that is not only economic but also having fine benefit improves mode to improve diaphragm function.
The Green (Glenn) in the U.S. in 1967 has invented the diaphragm pacemaker implanted, is mainly used in chronic ventilation work(
Can not entirely, the respiratory paralysis as caused by the central lesion such as central alveolar hypoventilation syndrome, brain stem, spinal cord.This implantation
The diaphragm pacemaker of formula, electrode is buried at left and right nervus phrenicus in vivo, and by respiratory rhythm, automatically unilateral or bilateral is led to from external
Electromagnetic coupled transmission electric pulse stimulation nervus phrenicus is crossed, reaching improves the purpose of respiratory function.The religion of Zhongshan Medical Univ. in 1987
Award invented external diaphragm pacemaker, and applied for patent.Chinese Patent Application No. CN87208778, CN89200051,
CN89220851、CN90109631、CN200720059728、CN200920053574、CN201020121786、
CN201220045744, CN200420105510 disclose the implementation of several external diaphragm pacemakers, although implementation
There is difference, but the electrical stimulation signal of output is all low-frequency electrostimulating signal, such as：In preceding 8 patents, instrument all makes in treatment
Low-frequency electrostimulating signal is used, with 40 hertz for optimal frequency, CN200420105510 provides 40 hertz and 2.5 hertz+40 hertz
Output frequency.The Implanted type diaphragm pace-maker of U.S. Green (Glenn) invention is also with low frequency output treatment signal.
In the physiatrics of medical science of recovery therapy field pulse current of the frequency below 1000 hertz be referred to as low-frequency current or
Low frequency pulse current.The method referred to as low frequency electrotherapy of human disease treatment is acted on using low frequency pulse current.Applying frequency
The method of 1K~100K hertz of pulse current treatment disease is referred to as medium frequency electrotherapy.
Existing electrotherapy theory thinks：The frequency of electric current of intermediate frequency is higher than low-frequency electrical, and is alternating current, acts on people
The electrology characteristic and produced physical and chemical effect and low-frequency electrical that human body is showed during body are significantly different.
1. tissue resistance can be overcome, compared with low-frequency electrical, deeper tissue tissue can be applied to different frequency electricity
The resistance of stream is different, and higher to the resistance of low-frequency electrical, with increasing for power frequency, the resistance of human body is gradually reduced.Except electricity
Hinder beyond characteristic, tissue also has the characteristic of electric capacity.The higher electric current of frequency is easier to by electric capacity, and medium frequency electric compares low frequency
Electricity is easy to by electric capacity.Obtained because human body is also small to the resistance of the higher alternating current of frequency and all relatively low therefore total impedance of capacitive reactance
Many, the electric current passed through is more.The current strength that medium frequency electrotherapy is applied is larger, up to 0.1~0.5mA/cm2, can reach
Depth to tissue is also deeper.
2. two-way electroless effect：Electric current of intermediate frequency is the higher alternating current of frequency, is that a kind of forward direction replaces change with negative sense
Faster electric current, point of no both positive and negative polarity.When electric current of intermediate frequency acts on human body, in the positive half cycle and negative half in each cycle of electric current
Ion in all in tissue is all reciprocated to different directions, thus can not be moved on to and caused cell reaction under electrode, electricity
No soda acid product is produced under extremely, by the chemical stimulation of soda acid product when the skin under electrode also will not be as direct current electrotherapy
And it is damaged.
3. excitor nerve musculature：Though medium frequency electric is obvious not as good as low-frequency electrical to the stimulation of motion, sensory nerve,
Adjustment effect to autonomic nerve, viscera function is but better than low-frequency electrical, and can be applied to tissue depth, is causing strong muscle
Skin is without obvious shouting pain while contraction.When medium frequency electric acts on skin, there is no strong impulse to nervus cutaneus and receptor, with
There was only slight vibratory sense during the medium frequency electric stimulation of threshold intensity, current strength only has picotement when increasing, nothing is not accommodated significantly
Pain, picotement gradually weakens when being persistently powered, and just occurs uncomfortable constraint sense when current strength is very big.Strong electric current of intermediate frequency thorn
The sensation swashed when causing sensation during contraction of muscle than low-frequency electrostimulating is much comfortable, patient during contraction of muscle occurs not bright
The sensation of aobvious pain, therefore patient is resistant to larger current strength during electrotherapy.
4. ease pain and stimulate circulation：10~15 minutes after various intermediate frequency electro ultrafiltrations, the capillary vessel number of partly open
Increase, VPV and CBF have increase, and local blood circulation improves.Medium frequency electric has inhibitory action to sensory nerve, can
Dermatalgia is above threshold risen, therefore have obvious analgesic activity.
5. the characteristics of electric current of intermediate frequency of low frequency modulations：The characteristics of electric current of intermediate frequency of low frequency modulations then has low, electric current of intermediate frequency concurrently.
It is now recognized that stimulating the most suitable electric current of lesion muscle not to be simple low frequency pulse current but by the intermediate frequency of low frequency modulations
Electric current, the electric current that it is used both contains medium frequency electric composition, the characteristics of having low-frequency electrical again.And this kind of electric current does not have low-frequency electrical
Shortcoming (such as effect table is shallow, big to skin irritatin, have electrolysis), but had low, medium frequency electric advantage and effect concurrently.
Due to history, the external diaphragm pacemaker produced both at home and abroad at present is all low-frequency electric pulse therapeutic system.
But this low-frequency electric pulse has the shortcomings that its is intrinsic：
As stimulation table is shallow, big to skin irritatin, has electrolysis, easily cause fatigue.The in vitro table of nervus phrenicus has one
Fixed distance, general electro photoluminescence, which is not easy to stimulate, arrives nervus phrenicus.In the past according to the external diaphram of low-frequency electric pulse principle design
Pacemaker, because stimulation table is shallow, differs surely to stimulate well and arrives nervus phrenicus, so curative effect is not ideal enough.
The content of the invention
In order to overcome the deficiencies in the prior art, it is an object of the invention to provide a kind of medium frequency electric stimulation of low frequency modulations
External diaphragm pacemaker, its amplitude changes with the change of the frequency and amplitude of low frequency signal, with low frequency, electric current of intermediate frequency
Feature and therapeutic action, the intermediate frequency electro ultrafiltration of low frequency modulations are deeper, are more suitable for the stimulation to nervus phrenicus, particularly nervus phrenicus in vitro
The deeper patient of table.
The purpose of the present invention is realized using following technical scheme：
A kind of external diaphragm pacemaker of the medium frequency electric stimulation of low frequency modulations, it includes low frequency modulations circuit, amount of bias and adjusted
Whole circuit, voltage amplitude adjustment circuit, power amplification circuit and isolating transformer, the low frequency modulations circuit enter to low frequency signal
The offset signal that the analog signal that row modulation is formed is produced with amount of bias adjustment circuit is overlapped, and the signal after superposition is passed through successively
Voltage amplitude is adjusted by voltage amplitude adjustment circuit, power amplification circuit is carried out after power amplification again by isolating transformation
Device output treatment signal.
Further, the low frequency modulations circuit is processor, after the processor is modulated to low frequency signal, by institute
State the analog signal after the D/A modular converters output modulation inside processor.
Further, the processor is STM32F103VET6.
Further, the amount of bias adjustment circuit includes zero offset circuit, resistance R148, resistance R150, resistance
R152, resistance R153 and amplifier U3, the analog signal after the D/A modular converters output modulation are connected by resistance R150
To amplifier U3 normal phase input end, the output end of zero offset circuit is also connected to amplifier U3 positive by resistance R148
Input, the resistance R153 is connected between amplifier U3 inverting input and amplifier U3 output end, the resistance
R152 one end is connected to amplifier U3 inverting input, and other end ground connection, the output end of the amplifier U3 is connected to electricity
Press the input of amplitude adjusting circuit.
Further, the zero offset circuit includes negative voltage source, slide rheostat RV1, resistance R146, resistance R147
And electric capacity C122, electric capacity C123 and amplifier U5, wherein, the negative voltage source passes sequentially through resistance R146, slide rheostat
It is grounded after RV1 and resistance R147, the sliding end of the slide rheostat is connected to amplifier U5 normal phase input end, the amplification
Device U5 inverting input is connected with its output end, and one end of the electric capacity C122 and electric capacity C123 are respectively connecting to amplifier U5
Inverting input and amplifier U5 output end, the other end of the electric capacity C122 and electric capacity C123 is grounded, the amplification
Device U5 output end is connected to amplifier U3 normal phase input end by resistance R148.
Further, the amount of bias adjustment circuit also follows circuit and second voltage to follow circuit including first voltage,
Wherein, the first voltage follows circuit to include amplifier U2 and resistance R149, and the second voltage follows circuit to include amplification
Device U4 and resistance R151, the analog signal after the D/A modular converters output modulation is connected to amplifier U2 by resistance R149
Normal phase input end, the output end of the amplifier U2 is connected to amplifier U3 normal phase input end by resistance R150, described
Amplifier U2 inverting input is connected with amplifier U2 output end, and the output end of the amplifier U3 is connected by resistance R151
Amplifier U4 normal phase input end is connected to, the inverting input of the amplifier U4 is connected with amplifier U4 output end, described
Amplifier U4 output end is connected to the input of voltage amplitude adjustment circuit.
Further, the voltage amplitude adjustment circuit includes digital regulation resistance U6, resistance R162, resistance R163, slip
Rheostat RV2, electrochemical capacitor C124 and electric capacity C126, the high voltage input of the digital regulation resistance U6 are connected by resistance R163
Amplifier U4 output end is connected to, the increase input and lifting input of the digital regulation resistance U6 are respectively connecting to processor
The first output end and the second output end, earth terminal, chip select input end and the low-voltage input of the digital regulation resistance U6
It is grounded, the power end of the digital regulation resistance U6 connects a positive supply, and the sliding end of the digital regulation resistance U6 is passed sequentially through
It is grounded after resistance R162 and slide rheostat RV2, the negative pole of the electrochemical capacitor C124 is connected to slide rheostat RV2 slip
End, the positive pole of the electrochemical capacitor C124 is connected to the input of power amplification circuit, and one end of the electric capacity C126 is grounded, separately
One end is connected to electrochemical capacitor C124 positive pole.
Further, the digital regulation resistance U6 is X9C103S.
Further, the power amplification circuit includes amplifier U7, resistance R164, resistance R166, resistance R167, electrolysis
Electric capacity C125, electrochemical capacitor C130, electric capacity C127 and electric capacity C129, the amplifier U7 normal phase input end are with electric capacity C126's
One end and electrochemical capacitor C124 positive pole are all connected with, the positive pole of the electrochemical capacitor C125 and electrochemical capacitor C130 positive pole point
Amplifier U7 output end and amplifier U7 inverting input, the negative pole and electrolysis electricity of the electrochemical capacitor C125 are not connected to
Appearance C130 negative pole is respectively connecting to the two ends of the armature winding of isolating transformer；After electric capacity C127 and resistance the R166 series connection
One end is connected to amplifier U7 output end, other end ground connection；Two ends difference after electric capacity C129 and resistance the R164 series connection
It is connected to amplifier U7 output end and amplifier U7 inverting input；One end ground connection of the resistance R167, the other end connects
It is connected to electrochemical capacitor C130 negative pole；Output treatment signal between the two ends of the secondary windings of the isolating transformer, described
Also bridging has electric capacity C128 and resistance R165 between the two ends of the secondary windings of isolating transformer.
Further, the external diaphragm pacemaker of the medium frequency electric stimulation of the low frequency modulations also includes a warning circuit, institute
State warning circuit including resistance R103, divider resistance R104, NPN triode Q24, buzzer LS1, voltage-regulator diode D18 and
Positive supply, the two ends of the buzzer LS1 are respectively connecting to positive supply and NPN triode Q24 colelctor electrode, the pole of voltage stabilizing two
Pipe D18 positive and negative electrode is connected to NPN triode Q24 and positive supply, and the base stage of the NPN triode Q24 passes through resistance
R103 is connected to the 3rd output end of processor, the grounded emitter of the NPN triode Q24, one end of the resistance R104
It is connected to NPN triode Q24 base stage, other end ground connection.
Compared with prior art, the beneficial effects of the present invention are：
The present invention is superimposed by low frequency modulations, amount of bias, voltage amplitude is adjusted, power amplification and isolating transformer cause
Its output result changes with the change of the frequency and amplitude of low frequency signal, the characteristics of with low frequency, electric current of intermediate frequency and treatment
Effect, the intermediate frequency electro ultrafiltration of low frequency modulations is deeper, is more suitable for the deeper trouble of the in vitro table of the stimulation to nervus phrenicus, particularly nervus phrenicus
Person.
Brief description of the drawings
Fig. 1 is the circuit theory diagrams of low frequency modulations circuit in the present invention；
Fig. 2 for the present invention in house dog timing circuit circuit theory diagrams；
Fig. 3 is the circuit theory diagrams of warning circuit in the present invention；
Fig. 4 is the circuit theory diagrams of amount of bias adjustment circuit in the present invention；
Fig. 5 is the circuit theory diagrams of zero offset circuit in the present invention；
Fig. 6 is the circuit theory diagrams of voltage amplitude adjustment circuit, power amplification circuit and isolating transformer in the present invention；
Fig. 7 is the oscillogram of sine wave；
Fig. 8 is the oscillogram of positive and negative square wave；
Fig. 9 is the oscillogram of positive and negative trapezoidal wave；
Figure 10 is the oscillogram of positive and negative sine wave；
Figure 11 is the oscillogram one of positive and negative triangular wave；
Figure 12 is the oscillogram two of positive and negative triangular wave；
Figure 13 is the oscillogram three of positive and negative triangular wave；
Figure 14 is the oscillogram four of positive and negative triangular wave；
Figure 15 is the oscillogram five of positive and negative triangular wave；
Figure 16 is the oscillogram of positive and negative exponential wave；
Figure 17 be when low-frequency modulation signal is that positive and negative square wave, intermediate frequency are half-sine wave, external diaphragm pacemaker output
Treat the oscillogram of signal；
Figure 18 is the oscillogram of positive negative pulse stuffing square wave；
Figure 19 is the oscillogram of half-sine wave；
Figure 20 is the oscillogram of square wave；
Figure 21 is the oscillogram of trapezoidal wave；
Figure 22 is the oscillogram of sine wave；
Figure 23 is the oscillogram one of triangular wave；
Figure 24 is the oscillogram two of triangular wave；
Figure 25 is the oscillogram three of triangular wave；
Figure 26 is the oscillogram four of triangular wave；
Figure 27 is the oscillogram five of triangular wave；
Figure 28 is the oscillogram of exponential wave；
Figure 29 is low-frequency modulation signal when being that square wave, intermediate frequency are half-sine wave, the treatment letter of external diaphragm pacemaker output
Number oscillogram；
Figure 30 is the oscillogram of pulse square wave；
Figure 31 is that intermediate frequency is sine wave, and low-frequency modulation signal is followed successively by positive and negative square wave, positive and negative trapezoidal wave, positive and negative triangular wave
First, positive and negative exponential wave, the oscillogram of the treatment signal of external diaphragm pacemaker output；
Figure 32 is that intermediate frequency is pulse square wave, and low-frequency modulation signal is followed successively by trapezoidal wave, square wave, triangular wave two, sine wave, referred to
Number ripple, the oscillogram of the treatment signal of external diaphragm pacemaker output；
Figure 33 is that intermediate frequency is pulse square wave and low-frequency modulation signal is trapezoidal wave, and then intermediate frequency is sine wave and low frequency modulations
Signal is positive and negative square wave, and intermediate frequency is positive negative pulse stuffing square wave and low-frequency modulation signal is positive and negative triangular wave one, and intermediate frequency is half-sine wave
And low-frequency modulation signal be square wave when, external diaphragm pacemaker output treatment signal oscillogram.
Embodiment
Below, with reference to accompanying drawing and embodiment, the present invention is described further, it is necessary to which explanation is, not
Under the premise of afoul, new implementation can be formed between various embodiments described below or between each technical characteristic in any combination
Example.
A kind of external diaphragm pacemaker of the medium frequency electric stimulation of low frequency modulations, it includes low frequency modulations circuit, amount of bias and adjusted
Whole circuit, voltage amplitude adjustment circuit, power amplification circuit and isolating transformer, low frequency modulations circuit are adjusted to low frequency signal
The offset signal that the analog signal that system is formed is produced with amount of bias adjustment circuit is overlapped, and the signal after superposition is successively via electricity
Pressure amplitude adjusting circuit voltage amplitude is adjusted, power amplification circuit carry out power amplification after it is defeated by isolating transformer again
Go out.
It refer to shown in Fig. 1, low frequency modulations circuit is processor U1, after processor U1 is modulated to low frequency signal, by
The analog signal after the output modulation of D/A modular converters inside processor, processor U1 uses STM32F103VET6 single-chip microcomputers,
Its 29th pin (PA4) exports analog signal.The peripheral circuit of STM32F103VET6 single-chip microcomputers is custom circuit, for example, figure
2 be its house dog timing circuit, and it includes resistance R97, electric capacity C82, resistance R96, resistance R98, resistance R99, electric capacity C83, electricity
Hold C84, electric capacity C85 and watchdog chip U8.Wherein, the two ends after resistance R97 and electric capacity C82 series connection are respectively connecting to 3.3V
Voltage source and ground, electric capacity C83 one end ground connection, the other end are connected to 3.3V voltage sources, after resistance R98 and electric capacity C84 connect
Two ends be respectively connecting to 3.3V voltage sources and ground, the two ends after resistance R99 and electric capacity C85 series connection are respectively connecting to 3.3V electricity
Potential source and ground, watchdog chip U8 use SP706SEN-L (SIPEX), and its hand-reset end (the 1st pin) is connected to resistance
Between R97 and electric capacity C82, power end (the 2nd pin) is connected to 3.3V voltage sources, earth terminal (the 3rd pin) ground connection, Power Supply Monitoring
Input (the 4th pin) is grounded or connected to power end (the 2nd pin), and Power Supply Monitoring output end (the 5th pin) keeps high level,
House dog input (the 6th pin) is connected to the 71st pin (PA12 ends) of STM32F103VET6 single-chip microcomputers, is additionally coupled to simultaneously
Between resistance R98 and electric capacity C84, reset output terminal (the 7th pin) is connected to the 14th pin of STM32F103VET6 single-chip microcomputers
(NRST ends), while being additionally coupled between resistance R99 and electric capacity C85, house dog output end (the 8th pin) is connected by resistance R96
It is connected to hand-reset end (the 1st pin).Other peripheral circuits are repeated no more here.
It refer to shown in Fig. 4, amount of bias adjustment circuit follows circuit, second voltage to follow circuit, zero including first voltage
Point biasing circuit, resistance R148, resistance R150, resistance R152, resistance R153 and amplifier U3, first voltage follow circuit bag
Amplifier U2 and resistance R149 are included, second voltage follows circuit to include amplifier U4 and resistance R151, D/A modular converter output tune
Analog signal after system is connected to amplifier U2 normal phase input end by resistance R149, and amplifier U2 output end passes through resistance
R150 is connected to amplifier U3 normal phase input end, and amplifier U2 inverting input is connected with amplifier U2 output end, and zero
The output end of point biasing circuit is also connected to amplifier U3 normal phase input end by resistance R148, and resistance R153 is connected to amplification
Between device U3 inverting input and amplifier U3 output end, resistance R152 one end is connected to amplifier U3 anti-phase input
End, other end ground connection, amplifier U3 output end is connected to amplifier U4 normal phase input end, amplifier U4 by resistance R151
Inverting input be connected with amplifier U4 output end, amplifier U4 output end is connected to the defeated of voltage amplitude adjustment circuit
Enter end.
It refer to shown in Fig. 5, zero offset circuit includes negative voltage source, slide rheostat RV1, resistance R146, resistance
R147 and electric capacity C122, electric capacity C123 and amplifier U5, wherein, negative voltage source passes sequentially through resistance R146, slide rheostat
It is grounded after RV1 and resistance R147, the sliding end of slide rheostat is connected to amplifier U5 normal phase input end, and amplifier U5's is anti-
Phase input is connected with its output end, and electric capacity C122 and electric capacity C123 one end are respectively connecting to amplifier U5 inverting input
With amplifier U5 output end, electric capacity C122 and electric capacity the C123 other end are grounded, and amplifier U5 output end passes through resistance
R148 is connected to amplifier U3 normal phase input end.Zero offset circuit generation -1.5V bias voltage, then amplifier U3's
One 0.5* (V of output end formationdac- 1.5) * (R153/R152+1) voltage signal, wherein：VdacExported for D/A modular converters
The value of analog signal after modulation, R153/R152 is the ratio between resistance R153 and resistance R152 resistance, and variable resistance is slided by adjusting
Device RV1 resistance, it is possible to achieve the adjustment of amount of bias.
It refer to shown in Fig. 6, voltage amplitude adjustment circuit includes digital regulation resistance U6, resistance R162, resistance R163, slip
Rheostat RV2, electrochemical capacitor C124 and electric capacity C126, digital regulation resistance U6 use X9C103S.Digital regulation resistance U6 high voltage
Input (the 3rd pin) is connected to amplifier U4 output end, digital regulation resistance U6 increase input (by resistance R163
2 pins) and lifting input (the 1st pin) be respectively connecting to STM32F103VET6 single-chip microcomputers the first output end (the 44th pipe
Pin) and the second output end (the 45th pin), digital regulation resistance U6 earth terminal (the 4th pin), chip select input end (the 7th pin) with
And low-voltage input (the 6th pin) is grounded, digital regulation resistance U6 power end (the 8th pin) connects a positive supply, numeral
Potentiometer U6 sliding end (the 5th pin) is passed sequentially through and is grounded after resistance R162 and slide rheostat RV2, electrochemical capacitor C124's
Negative pole is connected to slide rheostat RV2 sliding end, and electrochemical capacitor C124 positive pole is connected to the input of power amplification circuit,
Electric capacity C126 one end ground connection, the other end is connected to electrochemical capacitor C124 positive pole.Become by digital regulation resistance U6 and slip
Resistance device RV2 can be adjusted to the voltage amplitude of the output signal of amount of bias adjustment circuit.
It refer to shown in Fig. 6, power amplification circuit includes amplifier U7, resistance R164, resistance R166, resistance R167, electricity
Solve electric capacity C125, electrochemical capacitor C130, electric capacity C127 and electric capacity C129, amplifier U7 normal phase input end and the one of electric capacity C126
End and electrochemical capacitor C124 positive pole are all connected with, and electrochemical capacitor C125 positive pole and electrochemical capacitor C130 positive pole are connected respectively
To amplifier U7 output end and amplifier U7 inverting input, electrochemical capacitor C125 negative pole and bearing for electrochemical capacitor C130
Pole is respectively connecting to the two ends of the armature winding of isolating transformer；One end is connected to amplification after electric capacity C127 and resistance R166 series connection
Device U7 output end, other end ground connection；Two ends after electric capacity C129 and resistance R164 series connection are respectively connecting to the defeated of amplifier U7
Go out end and amplifier U7 inverting input；Resistance R167 one end ground connection, the other end is connected to electrochemical capacitor C130 negative pole；
Intermediate-freuqncy signal is exported between the two ends of the secondary windings of isolating transformer, between the two ends of the secondary windings of isolating transformer also
Bridging has electric capacity C128 and resistance R165.
It refer to shown in Fig. 3, the external diaphragm pacemaker of the medium frequency electric stimulation of low frequency modulations also includes a warning circuit, report
Alert circuit includes resistance R103, divider resistance R104, NPN triode Q24, buzzer LS1, voltage-regulator diode D18 and positive electricity
Source, buzzer LS1 two ends are respectively connecting to positive supply and NPN triode Q24 colelctor electrode, and voltage-regulator diode D18's is positive and negative
Pole is connected to NPN triode Q24 and positive supply, and NPN triode Q24 base stage is connected to processor by resistance R103
3rd output end, NPN triode Q24 grounded emitter, resistance R104 one end is connected to NPN triode Q24 base stage, separately
One end is grounded.
The medium frequency electric of low frequency modulations, its amplitude changes with the change of the frequency and amplitude of low frequency signal, with low frequency,
The characteristics of electric current of intermediate frequency and therapeutic action.The intermediate frequency electro ultrafiltration of low frequency modulations is deeper, is more suitable for the stimulation to nervus phrenicus, particularly
The deeper patient of the in vitro table of nervus phrenicus.
Contraction of diaphragm and diastole, cause contraction of diaphragm during respiratory movement during electrophrenic, so in low frequency modulations
Frequency electricity must use interval modulating wave mode, and in this fashion, amplitude-modulated wave and power-off are alternately present, and amplitude-modulated wave discontinuously occur.
Intermediate-freuqncy signal is as carrier wave, its frequency range 1K~100K hertz, and frequency is higher, and depth of interaction is deeper, in order to appropriate
Stimulation to nervus phrenicus, the frequency of intermediate frequency needs to select by human test.The methods and techniques of human test are not special at this
Explanation in profit.
Frequency range to the low-frequency modulation signal of diaphragm nerve stimulation is 10~300 hertz, and the waveform of low frequency is included but not
It is limited to square wave, trapezoidal wave, exponential wave, sine wave, triangular wave etc..
The treatment signal for the external diaphragm pacemaker that we design has the characteristics that：
1st, theoretical based on traditional electrotherapy, when by load of pure resistance to test, intermediate frequency is sine wave, such as Fig. 7
Shown, low-frequency modulation signal can be diversified forms, and including but not limited to positive and negative square wave (such as Fig. 8), positive and negative trapezoidal wave are (as schemed
9), positive and negative sine wave (such as Figure 10), positive and negative triangular wave one (such as Figure 11), positive and negative triangular wave two (such as Figure 12), positive and negative triangular wave three
(such as Figure 13), positive and negative triangular wave four (such as Figure 14), positive and negative triangular wave five (such as Figure 15), positive and negative exponential wave (such as Figure 16).
When low-frequency modulation signal is that positive and negative square wave, intermediate frequency are sine wave, the treatment signal of external diaphragm pacemaker output
As shown in figure 17, wherein T is the cycle of low-frequency modulation signal, and 1/T is the frequency f of low frequency signal.
2nd, traditional electrotherapy is expanded theoretical, when by load of pure resistance to test, intermediate frequency is positive negative pulse stuffing square wave,
As shown in figure 18, low-frequency modulation signal can be diversified forms, including but not limited to positive and negative square wave (such as Fig. 8), positive and negative trapezoidal wave
(such as Fig. 9), positive and negative sine wave (such as Figure 10), positive and negative triangular wave one (such as Figure 11), positive and negative triangular wave two (such as Figure 12), positive and negative triangle
Ripple three (such as Figure 13), positive and negative triangular wave four (such as Figure 14), positive and negative triangular wave five (such as Figure 15), positive and negative exponential wave (such as Figure 16).
3rd, electrotherapy is further expanded theoretical, when by load of pure resistance to test, intermediate frequency is half-sine wave, is such as schemed
Shown in 19, low-frequency modulation signal can be diversified forms, including but not limited to square wave (such as Figure 20), trapezoidal wave (such as Figure 21), just
String ripple (such as Figure 22), triangular wave one (such as Figure 23), triangular wave two (such as Figure 24), triangular wave three (such as Figure 25), triangular wave four are (as schemed
26), triangular wave five (such as Figure 27), exponential wave (such as Figure 28).
When low-frequency modulation signal is that square wave, intermediate frequency are half-sine wave, the treatment signal of external diaphragm pacemaker output is such as
Shown in Figure 29.
4th, electrotherapy is further expanded theoretical, when by load of pure resistance to test, intermediate frequency is pulse square wave, such as
Shown in Figure 30, low-frequency modulation signal can be diversified forms, including but not limited to square wave (such as Figure 20), trapezoidal wave (such as Figure 21),
Sine wave (such as Figure 22), triangular wave one (such as Figure 23), triangular wave two (such as Figure 24), triangular wave three (such as Figure 25), triangular wave four are (such as
Figure 26), triangular wave five (such as Figure 27), exponential wave (such as Figure 28).
5th, the signal that various intermediate-freuqncy signals and low frequency signal are combined into can be alternately present, to reach the mesh of lifting curative effect
's
For example：Example 1：Intermediate frequency is sine wave, and low-frequency modulation signal is followed successively by positive and negative square wave, positive and negative trapezoidal wave, positive and negative three
Angle ripple one, positive and negative exponential wave, the treatment signal of external diaphragm pacemaker output are as shown in figure 31.Example 2：Intermediate frequency is pulse side
Ripple, low-frequency modulation signal is followed successively by trapezoidal wave, square wave, triangular wave two, sine wave, exponential wave, external diaphragm pacemaker output
Treat signal as shown in figure 32.Example 3：Intermediate frequency is pulse square wave and low-frequency modulation signal is trapezoidal wave, and then intermediate frequency is sine
Ripple and low-frequency modulation signal are positive and negative square wave, and intermediate frequency is positive negative pulse stuffing square wave and low-frequency modulation signal is positive and negative triangular wave one, in
Frequency is half-sine wave and when low-frequency modulation signal is square wave, and the treatment signal of external diaphragm pacemaker output is as shown in figure 33.
Above-mentioned embodiment is only the preferred embodiment of the present invention, it is impossible to limit the scope of protection of the invention with this,
The change and replacement for any unsubstantiality that those skilled in the art is done on the basis of the present invention belong to institute of the present invention
Claimed scope.
Claims (10)
1. a kind of external diaphragm pacemaker of the medium frequency electric stimulation of low frequency modulations, it is characterised in that：It include low frequency modulations circuit,
Amount of bias adjustment circuit, voltage amplitude adjustment circuit, power amplification circuit and isolating transformer, the low frequency modulations circuit is to low
Frequency signal is modulated the offset signal that the analog signal to be formed produces with amount of bias adjustment circuit and is overlapped, the letter after superposition
Number voltage amplitude is adjusted via voltage amplitude adjustment circuit successively, power amplification circuit passes through again after carrying out power amplification
Isolating transformer output treatment signal.
2. the external diaphragm pacemaker of the medium frequency electric stimulation of low frequency modulations as claimed in claim 1, it is characterised in that：It is described low
Frequency modulation circuit is processor, after the processor is modulated to low frequency signal, the D/A moduluss of conversion inside the processor
Analog signal after block output modulation.
3. the external diaphragm pacemaker of the medium frequency electric stimulation of low frequency modulations as claimed in claim 2, it is characterised in that：The place
Reason device is STM32F103VET6.
4. the external diaphragm pacemaker of the medium frequency electric stimulation of low frequency modulations as claimed in claim 2, it is characterised in that：It is described inclined
The amount of putting adjustment circuit includes zero offset circuit, resistance R148, resistance R150, resistance R152, resistance R153 and amplifier U3,
Analog signal after the D/A modular converters output modulation is connected to amplifier U3 normal phase input end, zero by resistance R150
The output end of point biasing circuit is also connected to amplifier U3 normal phase input end by resistance R148, and the resistance R153 is connected to
Between amplifier U3 inverting input and amplifier U3 output end, one end of the resistance R152 is connected to amplifier U3's
Inverting input, other end ground connection, the output end of the amplifier U3 is connected to the input of voltage amplitude adjustment circuit.
5. the external diaphragm pacemaker of the medium frequency electric stimulation of low frequency modulations as claimed in claim 4, it is characterised in that：The zero point
Biasing circuit includes negative voltage source, slide rheostat RV1, resistance R146, resistance R147 and electric capacity C122, electric capacity C123 and put
Big device U5, wherein, the negative voltage source is passed sequentially through and is grounded after resistance R146, slide rheostat RV1 and resistance R147, the cunning
Move the normal phase input end that rheostatic sliding end is connected to amplifier U5, the inverting input and its output end of the amplifier U5
Be connected, one end of the electric capacity C122 and electric capacity C123 be respectively connecting to amplifier U5 inverting input and amplifier U5 it is defeated
Go out end, the other end of the electric capacity C122 and electric capacity C123 are grounded, and the output end of the amplifier U5 is connected by resistance R148
It is connected to amplifier U3 normal phase input end.
6. the external diaphragm pacemaker of the medium frequency electric stimulation of the low frequency modulations as described in claim 4 or 5, it is characterised in that：Institute
State amount of bias adjustment circuit also follows circuit and second voltage to follow circuit including first voltage, wherein, the first voltage with
Include amplifier U2 and resistance R149 with circuit, the second voltage follows circuit to include amplifier U4 and resistance R151, described
Analog signal after the output modulation of D/A modular converters is connected to amplifier U2 normal phase input end by resistance R149, described to put
Big device U2 output end is connected to amplifier U3 normal phase input end, the inverting input of the amplifier U2 by resistance R150
It is connected with amplifier U2 output end, the positive that the output end of the amplifier U3 is connected to amplifier U4 by resistance R151 is defeated
Enter end, the inverting input of the amplifier U4 is connected with amplifier U4 output end, the output end connection of the amplifier U4
To the input of voltage amplitude adjustment circuit.
7. the external diaphragm pacemaker of the medium frequency electric stimulation of low frequency modulations as claimed in claim 6, it is characterised in that：The electricity
Press amplitude adjusting circuit include digital regulation resistance U6, resistance R162, resistance R163, slide rheostat RV2, electrochemical capacitor C124 and
Electric capacity C126, the digital regulation resistance U6 high voltage input are connected to amplifier U4 output end, institute by resistance R163
The increase input and lifting input for stating digital regulation resistance U6 are respectively connecting to the first output end and the second output of processor
End, earth terminal, chip select input end and the low-voltage input of the digital regulation resistance U6 are grounded, the digital regulation resistance U6
Power end connect a positive supply, the sliding end of the digital regulation resistance U6 passes sequentially through resistance R162 and slide rheostat RV2
After be grounded, the negative pole of the electrochemical capacitor C124 is connected to slide rheostat RV2 sliding end, and the electrochemical capacitor C124 is just
Pole is connected to the input of power amplification circuit, and one end ground connection of the electric capacity C126, the other end is connected to electrochemical capacitor C124
Positive pole.
8. the external diaphragm pacemaker of the medium frequency electric stimulation of low frequency modulations as claimed in claim 7, it is characterised in that：The number
Word potentiometer U6 is X9C103S.
9. the external diaphragm pacemaker of the medium frequency electric stimulation of low frequency modulations as claimed in claim 7, it is characterised in that：The work(
Rate amplifying circuit includes amplifier U7, resistance R164, resistance R166, resistance R167, electrochemical capacitor C125, electrochemical capacitor C130,
Electric capacity C127 and electric capacity C129, the normal phase input end of the amplifier U7 and electric capacity C126 one end and electrochemical capacitor C124's
Positive pole is all connected with, and the positive pole of the electrochemical capacitor C125 and electrochemical capacitor C130 positive pole are respectively connecting to amplifier U7 output
End and amplifier U7 inverting input, the negative pole of the electrochemical capacitor C125 and electrochemical capacitor C130 negative pole are respectively connecting to
The two ends of the armature winding of isolating transformer；One end is connected to the defeated of amplifier U7 after electric capacity C127 and resistance the R166 series connection
Go out end, other end ground connection；Two ends after electric capacity C129 and resistance the R164 series connection are respectively connecting to amplifier U7 output end
With amplifier U7 inverting input；One end ground connection of the resistance R167, the other end is connected to electrochemical capacitor C130 negative pole；
Output treatment signal between the two ends of the secondary windings of the isolating transformer, the two of the secondary windings of the isolating transformer
Also bridging has electric capacity C128 and resistance R165 between end.
10. the external diaphragm pacemaker of the medium frequency electric stimulation of low frequency modulations as claimed in claim 2, it is characterised in that：It is described
The external diaphragm pacemaker of the medium frequency electric stimulation of low frequency modulations also includes a warning circuit, and the warning circuit includes resistance
R103, divider resistance R104, NPN triode Q24, buzzer LS1, voltage-regulator diode D18 and positive supply, the buzzer
LS1 two ends are respectively connecting to positive supply and NPN triode Q24 colelctor electrode, the positive and negative electrode point of the voltage-regulator diode D18
NPN triode Q24 and positive supply are not connected to, and the base stage of the NPN triode Q24 is connected to processor by resistance R103
3rd output end, the grounded emitter of the NPN triode Q24, one end of the resistance R104 is connected to NPN triode Q24
Base stage, the other end ground connection.
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| CN108042911A (en) * | 2017-12-14 | 2018-05-18 | 中山大学附属第医院 | Low-frequency modulated intermediate-frequency electrical stimulation external diaphragm pacemaker |
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| CN110639126A (en) * | 2019-08-24 | 2020-01-03 | 深圳市倍蓝科技有限公司 | Modulation type muscle electric pulse stimulation method and device |
| CN111317641A (en) * | 2019-12-26 | 2020-06-23 | 上海健康医学院 | Household intermediate frequency interference physiotherapy instrument circuit |
| CN113552424A (en) * | 2021-06-29 | 2021-10-26 | 中国人民解放军火箭军工程大学 | Weak static signal collection system of aeroengine gas circuit granule |
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| CN110639126A (en) * | 2019-08-24 | 2020-01-03 | 深圳市倍蓝科技有限公司 | Modulation type muscle electric pulse stimulation method and device |
| CN111317641A (en) * | 2019-12-26 | 2020-06-23 | 上海健康医学院 | Household intermediate frequency interference physiotherapy instrument circuit |
| CN113552424A (en) * | 2021-06-29 | 2021-10-26 | 中国人民解放军火箭军工程大学 | Weak static signal collection system of aeroengine gas circuit granule |
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