CN107137677A - Warm sun patch - Google Patents

Warm sun patch Download PDF

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Publication number
CN107137677A
CN107137677A CN201710216722.4A CN201710216722A CN107137677A CN 107137677 A CN107137677 A CN 107137677A CN 201710216722 A CN201710216722 A CN 201710216722A CN 107137677 A CN107137677 A CN 107137677A
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parts
root
medicine composition
radix
osteoarthropathy
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段练
段俊春
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/23Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A61K36/232Angelica
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/11Pteridophyta or Filicophyta (ferns)
    • A61K36/12Filicopsida or Pteridopsida
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/21Amaranthaceae (Amaranth family), e.g. pigweed, rockwort or globe amaranth
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/23Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A61K36/238Saposhnikovia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/26Aristolochiaceae (Birthwort family), e.g. heartleaf
    • A61K36/268Asarum (wild ginger)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/32Burseraceae (Frankincense family)
    • A61K36/324Boswellia, e.g. frankincense
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/32Burseraceae (Frankincense family)
    • A61K36/328Commiphora, e.g. mecca myrrh or balm of Gilead
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    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/48Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/481Astragalus (milkvetch)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/53Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
    • A61K36/537Salvia (sage)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/53Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
    • A61K36/538Schizonepeta
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/53Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
    • A61K36/539Scutellaria (skullcap)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/54Lauraceae (Laurel family), e.g. cinnamon or sassafras
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/70Polygonaceae (Buckwheat family), e.g. spineflower or dock
    • A61K36/708Rheum (rhubarb)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/71Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
    • A61K36/714Aconitum (monkshood)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/71Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
    • A61K36/718Coptis (goldthread)
    • AHUMAN NECESSITIES
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    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/88Liliopsida (monocotyledons)
    • A61K36/906Zingiberaceae (Ginger family)
    • A61K36/9068Zingiber, e.g. garden ginger
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/70Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • A61K9/703Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches

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Abstract

A kind of entitled temperature sun patch of the present invention, and in particular to Chinese medicine composition and its preparation and preparation method for treating osteoarthropathy.It is an object of the invention to provide a kind of Chinese medicine composition for treating osteoarthropathy, it can treat osteoarthropathy, have preferable therapeutic effect to osteoproliferation, scapulohumeral periarthritis, rheumatic arthritis, rheumatoid arthritis, cervical spondylopathy etc..Including following medicine composition:Radix Angelicae Sinensis, the red sage root, frankincense, myrrh, the root of bidentate achyranthes, levisticum, cassia twig, asarum is windproof, schizonepeta, the Radix Astragali, rhizoma zingiberis, rhizoma cibotii, tag processed, the coptis, radix scutellariae, rheum officinale.Another aspect of the present invention provides a kind of preparation method of external use plaster, specifically includes following steps:Dry medicine materical crude slice is taken, fine powder is worn into pulverizer, 120 mesh sieves is crossed, is put into container.Add rice vinegar, be tuned into dough, by 6g Chinese medicine dough hand rubbings into wad, be put on gauze, cover layer of transparent plastic paper, with finger press into diameter 8cm circular shaped plaster.

Description

Warm sun patch
Technical field
The present invention relates to key areas, and in particular to it is a kind of treat Bones and joints and Chinese medicine composition and its preparation and preparation Method.
Background technology
Osteoarthropathy(osteoarthritis, OA)Mainly based on cartilage, ligament, subchondral bone matter and synovial membrane inflammation Lesion is wanted, the progressive degenerative disease of total joint structure is then influenceed.Osteoarthropathy has substantial connection with age and wound, Therefore also known as degenerative arthritis.It is one of influence most common disease of human health, and is easier to influence compared with other diseases The capacity of gerontal patient, is to cause more than 50 years old crowd's function to be damaged, causes the master of economic loss and influence social development Want one of disease.
At present, the treatment for these diseases has Chinese traditional treatment method, also there is western medical treatment method, and Chinese traditional treatment is usually Using treatment method promoting blood circulation and removing blood stasis, but the purpose of recovery from illness is unable to reach using this method.With western medical treatment, generally using hand Art is treated, although operative treatment can play certain curative effect, is performed the operation and is brought great pain to the body and mind of patient.
The content of the invention
It is an object of the invention to provide a kind of Chinese medicine composition for treating osteoarthropathy, it can treat osteoarthropathy, There is preferable therapeutic effect to cervical spondylopathy, osteoproliferation, scapulohumeral periarthritis, rheumatic arthritis, rheumatoid arthritis etc..The present invention The preparation and preparation method of a kind of above-mentioned composition are additionally provided simultaneously.
The technical solution adopted in the present invention is:
A kind of external medicine composition for treating osteoarthropathy, it includes following medicine composition:
Radix Angelicae Sinensis, the red sage root, frankincense, myrrh, the root of bidentate achyranthes, levisticum, cassia twig, asarum is windproof, schizonepeta, the Radix Astragali, rhizoma zingiberis, rhizoma cibotii, tag processed, The coptis, radix scutellariae, rheum officinale.
It is preferred that, the external medicine composition of above-mentioned treatment osteoarthropathy, it include following weight than raw material:
10-30 parts of Radix Angelicae Sinensis, 15-45 parts of the red sage root, 6-18 parts of frankincense, 6-18 parts of myrrh, 8-28 parts of the root of bidentate achyranthes, 8-28 parts of levisticum, cassia twig 5-25 parts, 3-15 parts of asarum is windproof 6-30 parts, 6-18 parts of schizonepeta, 10-30 parts of the Radix Astragali, 5-25 parts of rhizoma zingiberis, 10-40 parts of rhizoma cibotii, system 6-18 parts of tag, 3-9 parts of the coptis, 3-15 parts of radix scutellariae, 2-8 parts of rheum officinale.
It is preferred that, the external medicine composition of above-mentioned treatment osteoarthropathy, it include following weight than raw material:
15-25 parts of Radix Angelicae Sinensis, 25-35 parts of the red sage root, 10-14 parts of frankincense, 10-14 parts of myrrh, 15-21 parts of the root of bidentate achyranthes, 15-21 parts of levisticum, 10-20 parts of cassia twig, 6-12 parts of asarum is windproof 12-24 parts, 9-15 parts of schizonepeta, 15-25 parts of the Radix Astragali, 10-20 parts of rhizoma zingiberis, rhizoma cibotii 20- 30 parts, tag 9-15 parts processed, 5-7 parts of the coptis, 6-12 parts of radix scutellariae, 4-6 parts of rheum officinale.
Most preferably, the external medicine composition of above-mentioned treatment osteoarthropathy, it include following weight than raw material:
The windproof 18 portions of chaste trees of 20 parts of Radix Angelicae Sinensis, 30 parts of the red sage root, 12 parts of frankincense, 12 parts of myrrh, 18 parts of the root of bidentate achyranthes, 18 parts of levisticum, 15 parts of cassia twig, 9 portions of asarum 12 parts of mustard, 20 parts of the Radix Astragali, 15 parts of rhizoma zingiberis, 25 parts of rhizoma cibotii, 12 portions of tag, 6 parts of the coptis, 9 parts of radix scutellariae, 5 parts of rheum officinale processed
Another aspect of the present invention provides a kind of preparation method of external use plaster, specifically includes following steps:Dry medicine materical crude slice is taken, is used Pulverizer wears into fine powder, crosses 120 mesh sieves, is put into container.Rice vinegar is added, dough is tuned into.Then hospital gauze is cut into 10* 10cm square, by 6g Chinese medicine dough hand rubbings into wad, is put on gauze, covers layer of transparent plastic paper, slow with finger The slow circular shaped plaster that diameter 8cm is forced into surrounding.
Further, it is characterised in that by traditional Chinese medicine fine powder and rice vinegar 1:1 weight is than adding rice vinegar.
In the present invention:
Radix Angelicae Sinensis-enriching blood purifies the blood, deficiency of blood blood is turbid, the weak numbness pain of impotence, and blood-breaking life is new.
The red sage root-promoting blood circulation for regulating menstruation, trusted subordinate's perverse trend, fever and chills accumulation, place blood lochia.
Muscle is stretched in frankincense-promoting blood circulation, by degrading the channel, expelling wind and clearing away cold, analgesic therapy of invigorating blood circulation.
Myrrh-dissipate blood detumescence, analgesic therapy myogenic, blood-breaking analgesic is torn open and hinders extravasated blood.
The root of bidentate achyranthes-cold-dampness Impotence numbness, spasm of limbs, arthralgia tonifies the liver and kidney.
Levisticum-wind pain is had a headache, and bodily pain pin pain, articular instability, rheumatism blocks up numbness.
Cassia twig-warming meridians and promoting circulation of qi, cheiropodagra, harmonizing yingfen and weifen, horizontal logical podomere.
Asarum-cough inverse headache, joint contraction, arthralgia pain due to rheumatism, improving eyesight is sensible.
It is windproof-to dissipate table sweating, wind bodily pain is blocked up, liver purging the liver of pathogenic fire is searched, wind prevailing over dampness is dissipated.
Schizonepeta-general mood harmony expires, crest pain, the tired pain of muscles and bones, brothers' muscular contracture.
The Radix Astragali-replenishing and restoring lung qi, the deficient exhaustion or lesion of the five internal organs, variola ulcer, eliminating toxic analgesic.
Rhizoma zingiberis-and except cold dissipating bind, middle benefit gas is by cold, Back to Yang Tongmai, cold limbs.
Rhizoma cibotii-tonifying Qi and blood, strengthening tendons benefit bone, caused by liver and kidney deficiency, the weak pain in the back of waist.
Tag processed-help positive Hui Yuan, mends fire and moves back cold, cold-dampness crippling wilt, deficiency-cold in spleen and stomach.
The coptis-thermal burn channels, blood overflows skin, then is hair spot, three burnt accumulated heats.
The inverse lung key of radix scutellariae-heat, then be hematemesis, clearing damp heat-clearing, and it imitates quite prompt.
Rheum officinale-hot harmony skin, then be carbuncle swells, expel the heat-evil by the stasis of blood, weed out the old and bring forth the new.
The present invention is directed to the clinical characters of osteoarthropathy, has prepared Radix Angelicae Sinensis, the red sage root, frankincense, myrrh, the root of bidentate achyranthes with promoting blood circulation The stasis of blood, swelling and pain relieving.Levisticum, cassia twig, asarum, windproof, schizonepeta, the Radix Astragali are with inducing diaphoresis to dispel wind, warming meridian.Rhizoma zingiberis, rhizoma cibotii, tag processed With the beneficial bone of strengthening tendons, warming and invigorating kidney Yang.The coptis, radix scutellariae, rheum officinale by the stasis of blood to expel the heat-evil.Collective effect can be subtracted with the work(of concurrence blood-activating analgetic The clinical symptoms of light osteoarthropathy, can be treated with help kidney yang from the basic origin cause of formation of disease.To cervical spondylopathy, hyperostosis Life, scapulohumeral periarthritis, rheumatic arthritis, rheumatoid arthritis etc. have preferable therapeutic effect.
Embodiment
The present invention is illustrated in further detail below in conjunction with embodiment.
Embodiment 1
It is a kind of adjust osteoarthropathy Chinese medicine composition, by following weight than raw material:20 parts of Radix Angelicae Sinensis, 30 parts of the red sage root, 12 parts of frankincense Windproof 12 parts of 18 portions of schizonepeta, 20 parts of the Radix Astragali, the 15 parts of rhizoma cibotii 25 of rhizoma zingiberis of 12 parts of myrrh, 18 parts of the root of bidentate achyranthes, 18 parts of levisticum, 15 parts of cassia twig, 9 parts of asarum Part 12 portions of tag, 6 parts of the coptis, 9 parts of radix scutellariae, 5 parts of rheum officinale processed.
Dry medicine materical crude slice is taken, fine powder is worn into pulverizer, 120 mesh sieves is crossed, is put into container.Rice vinegar is added, dough is tuned into. Then hospital gauze is cut into 10*10cm square, by 6g Chinese medicine dough hand rubbings into wad, is put on gauze, covers one Layer transparent plastic paper, diameter 8cm circular shaped plaster is slowly forced into finger to surrounding.
Embodiment 2
It is a kind of adjust osteoarthropathy Chinese medicine composition, by following weight than raw material:Radix Angelicae Sinensis 20g red sage root 30g frankincense 12g myrrhs The windproof 18g schizonepeta 12g Radixs Astragali 20g rhizoma zingiberis 15g rhizoma cibotii 25g tags 12g of 12g root of bidentate achyranthes 18g levisticum 18g cassia twig 15g asarums 9g are yellow Connect 6g radix scutellariae 9g rheum officinales 5g.Preparation method be the same as Example 1.
Embodiment 3
It is a kind of adjust osteoarthropathy Chinese medicine composition, by following weight than raw material:Radix Angelicae Sinensis 15g red sage root 20g frankincenses 9g does not have The windproof 12g schizonepeta 10g Radixs Astragali 15g rhizoma zingiberis 12g rhizoma cibotii 20g systems of medicine 9g root of bidentate achyranthes 12g levisticum 12g cassia twig 10g asarums 6g Tag 10g coptis 4g radix scutellariae 6g rheum officinales 3g.Preparation method be the same as Example 1.
Embodiment 4
It is a kind of adjust osteoarthropathy Chinese medicine composition, by following weight than raw material:Radix Angelicae Sinensis 40g red sage root 60g frankincenses 24g The windproof 36g schizonepeta 24g Radixs Astragali 40g rhizoma zingiberis 30g rhizoma cibotii of myrrh 24g root of bidentate achyranthes 36g levisticum 36g cassia twig 30g asarums 18g 50g tag 24g coptis 12g radix scutellariae 18g rheum officinales 10g.Preparation method be the same as Example 1.
Embodiment 5
It is a kind of adjust osteoarthropathy Chinese medicine composition, by following weight than raw material:Radix Angelicae Sinensis 10g red sage root 15g frankincenses 6g does not have The windproof 9g schizonepeta 9g Radixs Astragali 10g rhizoma zingiberis 7.5g rhizoma cibotii 12g systems of medicine 6g root of bidentate achyranthes 9g levisticum 9g cassia twig 7.5g asarums 4.5g Tag 6g coptis 3g radix scutellariae 4.5g rheum officinales 2.5g.Preparation method be the same as Example 1.
Above-described is only some embodiments of the present invention.For the person of ordinary skill of the art, not On the premise of departing from the invention design, various modifications and improvements can be made, these belong to the protection model of the present invention Enclose.
Embodiment 6
1 data and method
1.1 clinical datas and group technology
Selected case is from October, 2015 to the medical Human Osteoarthritis in Tian Run in June, 2016 hospitals of traditional Chinese hospital, Chinese medical discrimination Parting belongs to cold-dampness syndrome.Using random, parallel control Clinical Study Protocol, with district's groups method of randomization, SAS softwares are utilized Selected patient is randomly divided into 2 groups by PROCPLAN sentences:Treatment group and control group.Symptom before two groups of patient's general information and treatment Sign situation is shown in Table 1, and it is not statistically significant to compare difference between the sex ratio of two groups of patients, average age, course of disease group(P> 0.05), with comparativity.
1 two groups of general clinical datas of patient of table compare(±s)
Group Number of cases Man Female Age(Year) The course of disease(My god)
Treatment group 20 12 8 51.3±11.3 43.2±61.0
Control group 20 11 9 50.9±13.7 40.7±54.1
1.2 diagnostic criteria
Domestic orthopaedics and rheumatism are immunized section expert and have drafted osteoarthritis diagnosis and treatment guide under the support of the Ministry of Public Health within 2007.Knee Joint osteoarthritis diagnostic criteria:1. gonalgia repeatedly in nearly 1 month;2. X-ray film(Stand or Weight carrying position)Show between joint Gap narrows, Subchondral bone sclerosis and(Or)Cystis degeneration, joint margins spur are formed;3. joint fluid(At least 2 times)It is limpid, sticky, WBC < 2000 mL-1;4. middle-older patient(>=40 years old);5. morning stiffness≤30min;6. there is bony crepitus when movable(Sense).Wherein meet 1+ 2 or 1+ 3+ 5+ 6 or 1+ 4+ 5+ 6, diagnosable knee joint osteoarthritis.
1.3 inclusive criteria
1. knee osteoarthritis diagnosis is met;
2. Chinese medical discrimination is demonstrate,proved for cold-dampness numbness;
3. the age is between 40-70 Sui;
4. gonalgia visual analogue scales(Visual Analogue Scale,VAS)Scoring >=2;
5. informed consent form is voluntarily signed.
1.4 exclusion standard
1. the diseases such as serious cardiovascular, lung, liver, kidney, hemopoietic system are associated with;
2. the disease itself showed with arthritis, such as rheumatoid arthritis, ankylosing spondylitis, gout(Stage of attack);
3. the disease in joint is had influence on complication, such as psoriasis, luetic neuropathy, ochronosus, metabolic bone disease, acute Wound etc.;
4. it is inscribed within 4 weeks and has received glucocorticoid treatment(But receive glucocorticoid treatment dose stability at least 4 weeks;And recidivist Except);
5. nonsteroidal anti inflammatory anodyne was used to treat in 2 weeks(But it is steady to receive nonsteroidal anti inflammatory anodyne therapeutic dose Determine at least 2 weeks and except hair author);
6. pregnant woman or women breast-feeding their children or mental patient;
7. there are external plaster allergies;
8. other drugs clinical test is being participated in;
9. researcher thinks have other reasonses to be not suitable for clinical test.
1.5 treatment method
1.5.1 the phase is eluted
1. the elution phase for taking or using non-steroidal anti-inflammatory painkiller thing person to pass through 2 weeks;
2. the patient for receiving hormone therapy have to be larger than 30d into experiment predose is stable, and treatment is entered after the elution phase.
1.5.2 treatment group's administrated method
The attached temperature sun patch in osmanthus is main to be made up of cassia twig, monkshood, the root of bidentate achyranthes, the positive eliminating toxic dampness and heat medicine of levisticum isothermal.By the Tian Run hospitals of traditional Chinese hospital Pharmacy is ground Chinese herbal medicine with medicinal herb grinder respectively, is sieved with 120 mesh sieves, and mixing is admixed in proportion and is formed, is passed through Various techniques, hybrid modulation paste making agent external application.Each 20g, once a day, the course for the treatment of 4 weeks.
1.5.3 control group administrated method
By Diclofenac(Novartis Pharma AG produces, authentication code:Chinese medicines quasi-word H19990291)Extrude every time About 10cm or so, uniform outer be applied to suffers from knee, and gently rubs to medicine completely into tissue, and 3 times a day, continuous 2 weeks.
1.6 observation index and quantization modulation
Grade form is formulated with reference to Lequesne knee osteoarthritis seriousness and activity index Evaluation Method(Table 2), respectively at treatment Before, treatment after 2 weeks, treatment after 1 month to patient progress clinical score.
The knee osteoarthritis clinical score table of table 2
Project Scoring Project Scoring
Pain or discomfort 3. squat down
1. during night's rest Normally 0
Nothing is slight 0 It can complete, but sense is difficult 1
Only in motion or certain posture 1 Can not 2
When motionless 2 4. walked on uneven road
2. the morning stiffness time after getting up(min) Normally 0
<1 0 It can stand 1
1-15 1 Cannot 2
>15 2 Sign
3. during walking 1. tenderness 0
Without discomfort 0 Normally 0
Only after a segment distance of walking 1 Pain during weight 1
Start uncomfortable after walking aggravate 2 Pain during moderate pressure 2
4. maximum walking distance(m) Light pressure is pain
Unrestrictedly 0 2. kneecap mobility(cm)
>1000 1 >2.0 0
1000 2 2.0-1.0 1
<1000-900 3 <1.0-0.5 2
<900-500 4 <0.5-0.2 3
<500-100 5 3. range of motion()
<100 6 >120 0
Daily routines 120-110 1
1. go upstairs <110-90 2
Without influence 0 <90-60 3
Pain but reluctantly can on 1 <60-20 4
It can not go up or highly difficult 2 4. swelling
2. go downstairs Nothing 0
Without influence 0 Slightly swell, Xiyan understands 1
Pain but reluctantly can on 1 Xiyan is not clear 2
It can not go up or highly difficult 2 Xiyan is unclear, floating patella phenomenon(+) 3
Knee osteoarthritis VAS scores, using visual analogue scales(Visual Analogue Scale, VAS):Use a length 100mm pain visual imitation assessment scale, each scale represents 1 point, 100 points of total score.0mm ends represent painless, i.e., 0 point, 100mm ends represent insufferable most violent pain, i.e., 100 points, by graduated one side dorsad patient during Clinical practice, allow Patient marks on scale can represent the position of oneself pain degree, scale corresponding to the position that marks of doctor record patient and Fraction.Before treatment, after treatment scoring is made using same method.
1.7 statistical method
All data processings are analyzed using SPSS10.0 statistical softwares.Quantitative data represents with mean ± standard deviation, The t compared using the sample average of Group Design two is examined, and the comparison of the quantitative data of duplicate measurements is using Repeated Measurements Variance analysis, gender comparison uses chi-square criterion, and comparitive study uses single ordinal contingency data data Wilcoxon rank tests.System Meter inspection uses two-sided test, with P<0.05 is that difference is statistically significant.
2 results
Clinical score difference is statistically significant between different time points before and after treatment(F=217.20, P=0.000).2 kinds are not With between treatment method, difference is also statistically significant(F=5.45, P=0.000).2 weeks, 1 month after 2 groups of patient's treatments There is decline before relatively treating, difference is statistically significant(P<0.01).Point out treatment group compared with control group, there is improvement to face The effect of bed scoring.The clinical score of knee osteoarthritis after 2 groups of patients treat 1 month compares, and there is lower clinic in treatment group Score, but difference is not statistically significant(P>0.05).Pointing out treatment group to be treated with control group improves the effect phase of clinical score Seemingly, or even a more preferable improvement result is had.
The different time of measuring knee osteoarthritis clinical scores of 32 groups of patients of table (±s)
Group Before treatment 2 weeks after treatment 1 month after treatment
Treatment group 21.34±3.75 13.27±4.93## 12.13±5.07##
Control group 21.81±2.23 14.05±3.75## 15.71±4.22*##
Note:Compared with treatment group, * is P<0.05, * * is P<0.01, with being compared before treatment, # is P<0.05, ## is P<0.01.
Clinical score difference is statistically significant between different time points before and after treatment(F=137.98, P=0.000).2 kinds Between different treatment methods, difference is also statistically significant(F=13.11, P=0.000).2 weeks, 1 after 2 groups of patient's treatments There is decline the moon before relatively treating, and difference is statistically significant(P<0.01).Point out treatment group compared with control group, there is reduction The effect of arthralgia.The VAS scorings that 2 groups of patients treat 1 month are compared, and there is lower clinical score in treatment group, but difference does not have It is statistically significant(P>0.05).Point out treatment group similar to the effect that control group treats improvement clinical score.
VAS scorings are compared before and after 42 groups of case treatments of table(±s)
Group Before treatment 2 weeks after treatment 1 month after treatment
Treatment group 73.17±11.03 43.56±12.98## 23.14±11.08##
Control group 71.44±13.74 47.17±13.52## 24.77±12.19##
Note:Compared with treatment group, * is P<0.05, * * is P<0.01, with being compared before treatment, # is P<0.05, ## is P<0.01.
The cervical spondylopathy of model case medical record one
Chen, female, 50 years old, cervical syndrome and with hyperosteogeny, difficulty of walking.Many places are gone to a doctor, DeGrain.Use this After 5 courses for the treatment of of plaster treatment of invention, pain symptom disappears, and can normally walk and be engaged in light physical labor.Pay a return visit within 1 year, without multiple Hair.
The osteoproliferation of medical record two
Mr. Wang, male, 50 years old, suffers from hyperosteogeny, bends over throughout the year, difficulty in walking.After 6 courses for the treatment of of plaster treatment using the present invention, Can freedom of movement.
The scapulohumeral periarthritis of medical record three
Lee, female 38 years old, suffers from scapulohumeral periarthritis, shoulder pain 1 year is aggravated when tired, act, abduction limitation of activity in shoulder joint.Outside Lose money in a business after 3 courses for the treatment of of invention plaster, symptom progressively mitigates.
The rheumatic arthritis of medical record four
Zhao, female, 56 years old, rheumatic arthritis, double knee joint pain.Treated through antirheumatic, weight when light during symptom is often anti- It is multiple.After outer patch 6 courses for the treatment of of plaster of the present invention, symptom mitigation continues pain disappearance, function of joint after three courses for the treatment of of medication normal. Pay a return visit within 1 year, no recurrence.
The rheumatoid arthritis of medical record five
Zhang, female, 62 years old, rheumatoid arthritis, hand, sufficient many places arthralgia, partial joint deformation, difficulty in walking.Outer patch After 4 courses for the treatment of of plaster of the present invention, symptom mitigation continues pain after 3 courses for the treatment of of medication and disappears, can normally walk.

Claims (6)

1. a kind of external medicine composition for treating osteoarthropathy, it is characterised in that it includes following component:
Radix Angelicae Sinensis, the red sage root, frankincense, myrrh, the root of bidentate achyranthes, levisticum, cassia twig, asarum is windproof, schizonepeta, the Radix Astragali, rhizoma zingiberis, rhizoma cibotii, tag processed, The coptis, radix scutellariae, rheum officinale, rice vinegar.
2. a kind of external medicine composition for treating osteoarthropathy according to claim 1, it is characterised in that:It include with The raw material of lower parts by weight:
10-30 parts of Radix Angelicae Sinensis, 15-45 parts of the red sage root, 6-18 parts of frankincense, 6-18 parts of myrrh, 8-28 parts of the root of bidentate achyranthes, 8-28 parts of levisticum, cassia twig 5-25 parts, 3-15 parts of asarum is windproof 6-30 parts, 6-18 parts of schizonepeta, 10-30 parts of the Radix Astragali, 5-25 parts of rhizoma zingiberis, 10-40 parts of rhizoma cibotii, system 6-18 parts of tag, 3-9 parts of the coptis, 3-15 parts of radix scutellariae, 2-8 parts of rheum officinale, rice vinegar is some.
3. a kind of external medicine composition for treating osteoarthropathy according to claim 2, it is characterised in that:It include with The raw material of lower parts by weight:
15-25 parts of Radix Angelicae Sinensis, 25-35 parts of the red sage root, 10-14 parts of frankincense, 10-14 parts of myrrh, 15-21 parts of the root of bidentate achyranthes, 15-21 parts of levisticum, 10-20 parts of cassia twig, 6-12 parts of asarum is windproof 12-24 parts, 9-15 parts of schizonepeta, 15-25 parts of the Radix Astragali, 10-20 parts of rhizoma zingiberis, rhizoma cibotii 20- 30 parts, tag 9-15 parts processed, 5-7 parts of the coptis, 6-12 parts of radix scutellariae, 4-6 parts of rheum officinale, rice vinegar is some.
4. a kind of external medicine composition for treating osteoarthropathy according to claim 3, it is characterised in that:It include with The raw material of lower parts by weight:
The windproof 18 portions of chaste trees of 20 parts of Radix Angelicae Sinensis, 30 parts of the red sage root, 12 parts of frankincense, 12 parts of myrrh, 18 parts of the root of bidentate achyranthes, 18 parts of levisticum, 15 parts of cassia twig, 9 portions of asarum 12 parts of mustard, 20 parts of the Radix Astragali, 15 parts of rhizoma zingiberis, 25 parts of rhizoma cibotii, 12 portions of tag, 6 parts of the coptis, 9 parts of radix scutellariae, 5 parts of rheum officinale processed, rice vinegar is some.
5. a kind of preparation method of the Chinese medicine composition for the treatment of osteoarthropathy as described in claim any one of 1-4, its feature It is:Dry medicine materical crude slice is taken, fine powder is worn into pulverizer, 120 mesh sieves is crossed, is put into container;Rice vinegar is added, dough is tuned into.So Hospital gauze is cut into 10*10cm square afterwards, by 6g Chinese medicine dough hand rubbings into wad, is put on gauze, lid last layer Transparent plastic paper, diameter 8cm circular shaped plaster is slowly forced into finger to surrounding.
6. a kind of ointment for treating rheumatism as described in claim any one of 1-4, it is characterised in that by traditional Chinese medicine fine powder and rice vinegar 1:1 weight is than adding rice vinegar.
CN201710216722.4A 2017-04-05 2017-04-05 Warm sun patch Pending CN107137677A (en)

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN116509981A (en) * 2022-01-22 2023-08-01 范生昭 A kind of traditional Chinese medicine plaster for treating bruises, bone hyperplasia and bone spurs and its preparation method

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105770814A (en) * 2016-04-08 2016-07-20 段练 Laurel-attached yang warming plaster

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Publication number Priority date Publication date Assignee Title
CN105770814A (en) * 2016-04-08 2016-07-20 段练 Laurel-attached yang warming plaster

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蔡友毅等: ""以‘络脉痹阻’论治腰椎间盘突出症265例总结"", 《中医药导报》 *

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN116509981A (en) * 2022-01-22 2023-08-01 范生昭 A kind of traditional Chinese medicine plaster for treating bruises, bone hyperplasia and bone spurs and its preparation method

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