CN107136062A - A kind of agricultural synergist and Bifenazate, the mixture of etoxazole compound mixture and its preparation and application - Google Patents
A kind of agricultural synergist and Bifenazate, the mixture of etoxazole compound mixture and its preparation and application Download PDFInfo
- Publication number
- CN107136062A CN107136062A CN201710457200.3A CN201710457200A CN107136062A CN 107136062 A CN107136062 A CN 107136062A CN 201710457200 A CN201710457200 A CN 201710457200A CN 107136062 A CN107136062 A CN 107136062A
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- Prior art keywords
- bifenazate
- etoxazole
- mixture
- agricultural
- weight ratio
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- 238000002360 preparation method Methods 0.000 title abstract description 24
- IXSZQYVWNJNRAL-UHFFFAOYSA-N etoxazole Chemical compound CCOC1=CC(C(C)(C)C)=CC=C1C1N=C(C=2C(=CC=CC=2F)F)OC1 IXSZQYVWNJNRAL-UHFFFAOYSA-N 0.000 claims abstract description 27
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- 150000002191 fatty alcohols Chemical class 0.000 description 1
- 239000006260 foam Substances 0.000 description 1
- 125000003147 glycosyl group Chemical group 0.000 description 1
- 125000004836 hexamethylene group Chemical group [H]C([H])([*:2])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[*:1] 0.000 description 1
- 150000002576 ketones Chemical class 0.000 description 1
- 125000000400 lauroyl group Chemical group O=C([*])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 229910001629 magnesium chloride Inorganic materials 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 238000005374 membrane filtration Methods 0.000 description 1
- 239000003094 microcapsule Substances 0.000 description 1
- 239000002480 mineral oil Substances 0.000 description 1
- 235000010446 mineral oil Nutrition 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 229910052901 montmorillonite Inorganic materials 0.000 description 1
- 125000001400 nonyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- 230000003151 ovacidal effect Effects 0.000 description 1
- 150000002918 oxazolines Chemical class 0.000 description 1
- 239000001301 oxygen Substances 0.000 description 1
- 229910052760 oxygen Inorganic materials 0.000 description 1
- 229910052625 palygorskite Inorganic materials 0.000 description 1
- 230000000361 pesticidal effect Effects 0.000 description 1
- 239000003090 pesticide formulation Substances 0.000 description 1
- 239000003208 petroleum Substances 0.000 description 1
- 239000012071 phase Substances 0.000 description 1
- ZUOUZKKEUPVFJK-UHFFFAOYSA-N phenylbenzene Natural products C1=CC=CC=C1C1=CC=CC=C1 ZUOUZKKEUPVFJK-UHFFFAOYSA-N 0.000 description 1
- 150000003014 phosphoric acid esters Chemical class 0.000 description 1
- 230000035479 physiological effects, processes and functions Effects 0.000 description 1
- 239000002574 poison Substances 0.000 description 1
- 231100000614 poison Toxicity 0.000 description 1
- 229920005862 polyol Polymers 0.000 description 1
- 229920002451 polyvinyl alcohol Polymers 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- QQONPFPTGQHPMA-UHFFFAOYSA-N propylene Natural products CC=C QQONPFPTGQHPMA-UHFFFAOYSA-N 0.000 description 1
- 125000004805 propylene group Chemical group [H]C([H])([H])C([H])([*:1])C([H])([H])[*:2] 0.000 description 1
- 239000002994 raw material Substances 0.000 description 1
- 238000012827 research and development Methods 0.000 description 1
- OARRHUQTFTUEOS-UHFFFAOYSA-N safranin Chemical compound [Cl-].C=12C=C(N)C(C)=CC2=NC2=CC(C)=C(N)C=C2[N+]=1C1=CC=CC=C1 OARRHUQTFTUEOS-UHFFFAOYSA-N 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 108700004121 sarkosyl Proteins 0.000 description 1
- 150000003335 secondary amines Chemical class 0.000 description 1
- 229920005573 silicon-containing polymer Polymers 0.000 description 1
- KSAVQLQVUXSOCR-UHFFFAOYSA-M sodium lauroyl sarcosinate Chemical compound [Na+].CCCCCCCCCCCC(=O)N(C)CC([O-])=O KSAVQLQVUXSOCR-UHFFFAOYSA-M 0.000 description 1
- 229910052938 sodium sulfate Inorganic materials 0.000 description 1
- 235000011152 sodium sulphate Nutrition 0.000 description 1
- 239000001587 sorbitan monostearate Substances 0.000 description 1
- 235000011076 sorbitan monostearate Nutrition 0.000 description 1
- 229940035048 sorbitan monostearate Drugs 0.000 description 1
- 239000003549 soybean oil Substances 0.000 description 1
- 235000012424 soybean oil Nutrition 0.000 description 1
- 239000007921 spray Substances 0.000 description 1
- 239000008107 starch Substances 0.000 description 1
- 235000019698 starch Nutrition 0.000 description 1
- 210000002784 stomach Anatomy 0.000 description 1
- KDYFGRWQOYBRFD-UHFFFAOYSA-L succinate(2-) Chemical compound [O-]C(=O)CCC([O-])=O KDYFGRWQOYBRFD-UHFFFAOYSA-L 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- XFNJVJPLKCPIBV-UHFFFAOYSA-N trimethylenediamine Natural products NCCCN XFNJVJPLKCPIBV-UHFFFAOYSA-N 0.000 description 1
- 230000001018 virulence Effects 0.000 description 1
- 239000002699 waste material Substances 0.000 description 1
- 239000008096 xylene Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
- A01N25/30—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests characterised by the surfactants
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/72—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms as ring hetero atoms
- A01N43/74—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms as ring hetero atoms five-membered rings with one nitrogen atom and either one oxygen atom or one sulfur atom in positions 1,3
- A01N43/76—1,3-Oxazoles; Hydrogenated 1,3-oxazoles
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N47/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid
- A01N47/08—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid the carbon atom having one or more single bonds to nitrogen atoms
- A01N47/10—Carbamic acid derivatives, i.e. containing the group —O—CO—N<; Thio analogues thereof
- A01N47/24—Carbamic acid derivatives, i.e. containing the group —O—CO—N<; Thio analogues thereof containing the groups, or; Thio analogues thereof
Abstract
The invention discloses a kind of agricultural synergist and Bifenazate, the mixture of etoxazole compound mixture and its preparation and application, in mixture, the agricultural synergist is N 380, the Bifenazate and the compound of etoxazole are acaricide, and the agricultural synergist is 1 with the acaricidal weight ratio:0.5 30, the weight ratio of the Bifenazate and etoxazole is 1:8‑50.It is used to increase the purposes that acaricide penetrates evil mite body surface, and application of the mixture for preventing and treating Agricultural Mites the invention further relates to the agricultural synergist.
Description
Technical field
The present invention relates to agriculture field, specifically a kind of agricultural synergist and Bifenazate, etoxazole compound mixture
Mixture and its preparation and application.
Background technology
China is a large agricultural country, the use of agricultural chemicals is be unable to do without in actual agricultural production, still, with agricultural pests
The influence of the extension of chemical prevention medication history, the agricultural chemicals not factor such as scientifical use, it follows that agricultural pests resistance day
Beneficial serious, the pest species for producing resistance are persistently increasing, and are one of current agricultural problems for being badly in need of solving.
Bifenazate (bifenazate) is biphenyl hydrazine acaricide, and sterling is white solid, is a kind of new selective
Foliar spray acaricide, belongs to non-internal-absorting acaricide, to each life stage of mite effectively, with ovicidal activity and into
Mite knocks down activity, influences minimum to predatory mite, is very suitable for the comprehensive regulation of insect.
Etoxazole (etoxazole) is a kind of acaricide of SUMITOMO CHEMICAL KCC research and development, belongs to diphenyl evil
Oxazoline derivative, mainly tags and stomach poison function, substantially without absorbability, ovum, young mite, deutonymph etc. can be prevented and treated, to citrus, apple
Fruits and vegetables, the tetranychid of flowers and other crops volume, Panonychus citri, Tetranychus urticae, Tetranychus cinnabarinus etc. are effectively.
A kind of miticide compositions containing etoxazole and Bifenazate of Chinese patent CN101999382A, can be configured to moisture and dissipate
Granula, suspending agent, wettable powder, dispersible oil-suspending agent, missible oil, aqueous emulsion or micro-emulsion form, to citrus, apple tree,
Cotton red spider has preferable prevention effect.
Chinese patent CN104054732A discloses a kind of agricultural acaricides aqueous suspension agent composition, specifically comprising etoxazole
And Bifenazate, the preventive effect to tetranychid can be effectively improved.
Chinese patent CN105613542A discloses a kind of Synergistic mite killing composition containing etoxazole and Bifenazate, formulation
For suspending agent, aqueous emulsion, microemulsion, water dispersible granules, wettable powder, ultra low volume liquids, microcapsule suspending agent etc., with association
Same synergistic effect, usage amount is few, cost is low, for preventing and treating Panonychus citri, Tetranychus urticae, the section shapes such as field crop, water fruits and vegetables
Tetranychid, Tetranychus cinnabarinus etc..
Although prior art discloses Bifenazate and the compound of etoxazole, but the research of this respect only resides within association
With synergy aspect, namely by indoor or field experiment, composition is determined relative to the virulence or preventive effect of single dose, is not carried out more
Profound research or improvement, prior art is never concerned about or paid attention to the effective rate of utilization after pharmacy application, for example, penetrates evil
The dose of mite body surface, which results in unnecessary waste.
N-380 is that a kind of commercially available APEO is modified trisiloxanes class material, is new function auxiliary agent, it is known that with compared with
Good wettability, and can effectively suppress in Pesticide formulation foam generation.
The content of the invention
The above mentioned problem existed based on prior art, the present inventor have passed through long-term pesticidal preparations, acarid body surface physiology
Research in terms of, finishing screen, which have selected one kind, can be effectively increased the Pesticide penetration acarid body surface such as Bifenazate, etoxazole
Agricultural synergist, beyond theory expectation.Based on the discovery, inventor completes the present invention.
It is an object of the invention to provide a kind of agricultural synergist and Bifenazate, the mixture of etoxazole compound mixture
And its prepare and apply.
The present invention is achieved through the following technical solutions.
A kind of agricultural synergist and Bifenazate, the mixture of etoxazole compound mixture, wherein, the agricultural synergist
For N-380；The Bifenazate and the compound of etoxazole are acaricide.
Wherein N-380 is the compound for the APEO modification trisiloxanes class compound for meeting following structures：
Wherein, n=14-16, and the mol ratio M of threen14:Mn15:Mn16=1-2:1-2:1-2。
In the mixture of the present invention, the agricultural synergist is 1 with the acaricidal weight ratio:0.5-30, preferably
1:1-25, more preferably 1:5-9.
In the mixture of the present invention, the weight ratio of the Bifenazate and etoxazole is 1:8-50, preferably 1:12-24,
More preferably 1:15.
According to the mixture of the present invention, wherein, the mixture also includes agriculturally acceptable carrier and/or auxiliary agent,
Be prepared into agriculturally acceptable formulation, be preferably prepared to aqueous emulsion, microemulsion, missible oil, wettable powder, water dispersible granules,
Suspending agent.
Above-mentioned formulation is this area regular dosage form, what its preparation method was well known to those skilled in the art, is prepared into
Auxiliary agent and/or carrier and its consumption used in above-mentioned various formulations are similarly well-known to those skilled in the art, for example, join
According to《Formulations of pesticide process technology》.Acceptable carrier and auxiliary agent include but is not limited on agricultural chemicals used：Solvent, emulsifying agent, point
Powder, wetting agent, adhesive, disintegrant, thickener, antifreezing agent, stabilizer, preservative, filler and/or carrier etc..Ability
Field technique personnel can select one or more auxiliary agents and/or carrier therein.
In one embodiment of the invention, the mixture of the present invention is prepared into suspending agent, its formula composition is：Kill
Mite agent compound 1-50%, N-380 0.1-10%, dispersant 1-25%, wetting agent 1-25%, thickener 0.1-5%, antifreezing agent 0.5-
5%, defoamer 0.1-5%, preservative 0-5%, water complement to 100%.Its preparation method is：By active ingredient and various auxiliary agents with
Water is mixed, after high speed shear is scattered, sand mill is sanded, and forms high dispersive, stable suspension system, suspending agent is made.
In one embodiment of the invention, the mixture of the present invention is prepared into wettable powder, it is formulated composition
For：Acaricide compound 1-50%, N-380 0.1-10%, dispersant 1-25%, wetting agent 1-25%, solid carrier is complemented to
100%.Its preparation method is：Each component is mixed, wettable powder is made in ground, crushing.
In one embodiment of the invention, the mixture of the present invention is prepared into aqueous emulsion, its formula composition is：Kill
Mite agent compound 1-50%, N-380 0.1-10%, solvent 1-40%, emulsifying agent 1-25%, dispersant 1-25%, thickener 0.5-5%,
Defoamer 0.5-5%, antifreezing agent 0.5-5%, stabilizer 0-5%, water complements to 100%.Its preparation method is：By acaricide compound
Oil phase is prepared into solvent dissolving, other each components are added to the water to stir are prepared into aqueous phase, then while stirring by oil
Aqueous phase is added to, is stirred, aqueous emulsion is made.
In one embodiment of the invention, the mixture of the present invention is prepared into water dispersible granules, it is formulated composition
For：Acaricide compound 1-50%, N-380 0.1-10%, dispersant 1-25%, wetting agent 1-25%, disintegrant 1-10%, binding agent
0.1-5%, solid carrier complements to 100%.Its preparation method is：Each component is well mixed, moisture is made in size-reduced, granulation
Shot agent.
Wherein, in above-mentioned formula, the solvent can be selected：Methanol, ethanol, isopropanol, benzene,toluene,xylene, third
Ketone, dimethylformamide, dimethyl sulfoxide (DMSO), dichloromethane, hexamethylene, cyclohexanone, 1-METHYLPYRROLIDONE, petroleum ether, acetic acid
One or more in ethyl ester；
The emulsifying agent can be selected：Sodium lignin sulfonate, lauryl sodium sulfate, neopelex, dodecyl
Benzene sulfonic acid calcium, styryl phenyl APEO, phenethyl phenol polyoxyethylene poly-oxygen propylene aether, aliphatic alcohol polyethenoxy
Ether, thermally coupled distillation columns, castor oil polyoxyethylene ether phosphate, phenyl phenol polyoxyethanyl ether phosphate, naphthalene sulphur
Hydrochlorate formaldehyde condensation products, benzyl dimethyl phenol polyoxyethyl ether, sorbitan monostearate APEO, Sorbitan
One or more in polyol fatty acid ester APEO；
The dispersant can be selected：Alkylphenol phosphoric acid ester sodium, naphthalenesulfonate formaldehyde condensation compound, naphthalene sulfonic acid-formaldehyde condensation product
It is sodium salt, APES formaldehyde condensation product, glycerine fatty acid APEO, polyoxyethylene alkylaryl ether, wooden
Plain sodium sulfonate, fatty alcohol polyoxyethylene ether sulfate, AEO, aliphatic alcohol polyoxyvinethene phosphate, nonyl
One or more in phenol polyethenoxy ether, polyoxyethylene lanolin alcohol, Polyoxyethylene Sorbitan acid esters；
The wetting agent can be selected：Disecoctylmaleate sodium sulfonate, N- sodium lauroyl glutamates, dodecyl sulphur
Sour sodium, triphenoethyl benzene phenol polyethenoxy ether, calcium dodecyl benzene sulfonate, isooctanol Disodium sulfosuccinate, lauroyl flesh
One or more in propylhomoserin sodium, castor oil polyoxyethylene ether, AEO；
Described adhesive can be selected：In gelatin, Arabic gum, xanthans, starch, carboxymethyl cellulose, carboxyethyl cellulose
One or more；
The disintegrant can be selected：One or more in sodium sulphate, calcium sulfate, sodium acid carbonate, ammonium sulfate, magnesium chloride；
The thickener can be selected：In polyvinyl acetate, aluminium-magnesium silicate, Arabic gum, xanthans, gelatin, polyvinyl alcohol
One or more；
The defoamer can be selected：：In dimethyl silicone polymer, butylphosphoric acid ester, phosphoric acid isobutyl ester, n- octanol, silicone etc.
It is one or more；
The antifreezing agent can be selected：One or more in ethylene glycol, propane diols, glycerine etc.；
The stabilizer can be selected：Triphenyl phosphite, N- soybean oleyl trimethylene diamine, dialkyl group succinate sulfonic acid
One or more in salt, epoxychloropropane, butyl glycidyl ether etc.；
The preservative can be selected：One or both of sodium benzoate, benzoic acid；
The filler and/or carrier include solid packing and/or carrier and liquid filler and/or carrier.Wherein, solid packing
And/or carrier can be selected：One kind in diatomite, kaolin, attapulgite, white carbon, bentonite, montmorillonite, calcium carbonate
Or it is a variety of.The one or more that liquid filler and/or carrier can be selected in water, castor oil, soybean oil, mineral oil.
Another aspect of the present invention is related to a kind of agricultural synergist and is used to increase the purposes that acaricide penetrates evil mite body surface, wherein, institute
Agricultural synergist is stated for N-380；The acaricide is Bifenazate and the compound of etoxazole.
Wherein, the agricultural synergist and the acaricidal weight ratio are 1:0.5-30, preferably 1:1-25, more preferably 1:
5-9。
The weight ratio of the Bifenazate and etoxazole is 1:8-50, preferably 1:12-24, more preferably 1:15.
The evil mite is plant evil mite, such as ovum, larva, nymph, adult, specifically includes T.urticae Koch
(Tetranychusurticae), citrus tetranychid (Panonychuscitri), coffee unguiculus mite (Oligonychuscoffee)、
Cotton spider mites (Tetranychustelarius), thorn apple rust mite (Aculusschlechtendali), panonychus ulmi
(Panonychusulmi), apple tetranychus (Panonychusulmi), Tetranychus cinnabarinus (Tetranychus cinnabarinus)
Deng.It is preferred that citrus tetranychid (Panonychuscitri) and apple tetranychus (Panonychusulmi).More preferably citrus tetranychid
(Panonychuscitri)。
Another aspect of the present invention is related to the purposes that mixture of the present invention is used to prevent and treat Agricultural Mites.Wherein, it is described
Evil mite be plant evil mite, such as ovum, larva, nymph, adult, specifically include T.urticae Koch (Tetranychusurticae)、
Citrus tetranychid (Panonychuscitri), coffee unguiculus mite (Oligonychuscoffee), cotton spider mites
(Tetranychustelarius), thorn apple rust mite (Aculusschlechtendali), panonychus ulmi
(Panonychusulmi), apple tetranychus (Panonychusulmi), Tetranychus cinnabarinus (Tetranychus cinnabarinus)
Deng.It is preferred that citrus tetranychid (Panonychuscitri) and apple tetranychus (Panonychusulmi).More preferably citrus tetranychid
(Panonychuscitri)。
The amount of application of inventive mixture（It is converted to acaricide compound）For such as 0.1-1000g ai./ha, preferably 1-
200g ai./ha。
Various raw materials used herein and/or reagent are commercially available.For example, the acaricide and various auxiliary agents, carrier are equal
Can easily commercially；The synergist N-380 is also commercially available, for example, can be purchased from promise agriculture Beijing world raw
Thing Technology Co., Ltd. etc..
Unless otherwise indicated, " % " involved in the present invention is " percentage by weight ".
Embodiment
The present invention is further described with reference to specific embodiment, but does not limit the invention to these tools
Body embodiment.One skilled in the art would recognize that present invention encompasses potentially included in Claims scope
All alternatives, improvement project and equivalents.
N-380 used in following embodiments is purchased from promise agriculture Beijing International Biotechnology Co., Ltd, and mol ratio Mn14:
Mn15:Mn16=1:2:1。
Unless otherwise indicated, involved " % " is " percentage by weight ".
（One）Preparation prepares embodiment
The aqueous emulsion of preparation example 1
Bifenazate 1%, etoxazole 8%, N-380 1%, ethyl acetate 10%, lauryl sodium sulfate 6%, aliphatic alcohol polyethenoxy
Ether phosphate 2%, Arabic gum 1%, butylphosphoric acid ester 0.5%, ethylene glycol 4%, water complements to 100%.
Its preparation method is：Each component is mixed with water, after high speed shear is scattered, sand mill is sanded, formation high dispersive,
Stable suspension system, is made suspending agent.
The aqueous emulsion of preparation example 2
Bifenazate 0.5%, etoxazole 10%, N-380 0.5%, ethyl acetate 12%, calcium dodecyl benzene sulfonate 5%, glycerin fatty
Sour APEO 4%, polyvinyl acetate 1%, phosphoric acid isobutyl ester 0.5%, propane diols 5%, water complements to 100%.
Its preparation method is：Each component is mixed with water, after high speed shear is scattered, sand mill is sanded, formation high dispersive,
Stable suspension system, is made suspending agent.
The suspending agent of preparation example 3
Bifenazate 1%, etoxazole 24%, N-380 1.67%, Polyoxyethylene Sorbitan acid esters 8%, N- lauroyl paddy
Propylhomoserin sodium 4%, aluminium-magnesium silicate 1%, ethylene glycol 3%, silicone 0.5%, sodium benzoate 0.5%, water complements to 100%.
Its preparation method is：Each component is mixed with water, after high speed shear is scattered, sand mill is sanded, formation high dispersive,
Stable suspension system, is made suspending agent.
The water dispersible granules of preparation example 4
Bifenazate 1%, etoxazole 15%, N-380 2%, naphthalene sulfonic acid-formaldehyde condensation product sodium salt 6%, maleic acid di-sec-octyl sulphur
Sour sodium 4%, calcium sulfate 4%, Arabic gum 4%, diatomite complements to 100%.
Its preparation method is：Each component is well mixed, water dispersible granules are made in size-reduced, granulation.
The water dispersible granules of preparation example 5
Bifenazate 1.5%, etoxazole 18.5%, N-380 4%, NPE 5%, isooctanol Disodium sulfosuccinate
5%, ammonium sulfate 5%, carboxyethyl cellulose 5%, bentonite complements to 100%.
Its preparation method is：Each component is well mixed, water dispersible granules are made in size-reduced, granulation.
The wettable powder of preparation example 6
Bifenazate 1%, etoxazole 32%, N-380 2.1%, polyoxyethylene lanolin alcohol 8%, sodium N-lauroyl sarcosinate 3%, silicon
Diatomaceous earth complements to 100%.
Its preparation method is：Each component is mixed, wettable powder is made in ground, crushing.
The wettable powder of preparation example 7
Bifenazate 2%, etoxazole 30%, N-380 4%, aliphatic alcohol polyoxyvinethene phosphate 6%, isooctanol succinate sulfonic acid
Sodium 6%, kaolin complements to 100%.
Its preparation method is：Each component is mixed, wettable powder is made in ground, crushing.
（Two）Evil mite body surface penetration test
1st, citrus tetranychid is tested
For examination evil mite：Citrus tetranychid (Panonychuscitri)
Reagent agent and comparison medicament：Bifenazate, etoxazole；Cyflumetofen
For examination synergist and control auxiliary agent：N-380；NF-100（A kind of glycosyl modified organic silicon auxiliary agent）, penetrant t
Test method：
Bifenazate and etoxazole compound that total concentration is 5000mg/L are prepared with ethyl acetate（Bifenazate:Etoxazole=1:
15）Mother liquor, and the cyflumetofen mother liquor that concentration is 5000mg/L, it is standby.
A certain amount of synergist N-380, and control auxiliary agent NF-100 and penetrant t are weighed respectively, and each personal distilled water is matched somebody with somebody
Concentration is made and is 50 mg/L solution, and is divided into several pieces.According to the experimental design of such as table 1 below, divide into the solution prepared
The a certain amount of mite killing medicament mother liquor prepared in advance is not added, is 400mg/L to drug concentration.Mite killing medicament is with increasing in each solution
The weight ratio for imitating agent is 8:1.
Select citrus tetranychid nymph of the same size.Take dactylethrae some, 100 nymphs are placed in each dactylethrae, so
Each processing solution 5ml prepared is each added afterwards, dactylethrae is then fixed on shaking table, and keeps gently rocking.1 hour
Afterwards, solution in dactylethrae is outwelled, and cleans with ethyl acetate deutonymph surface 3 times, to clean the medicament of deutonymph surface remaining.
Using improved QuEChERS extraction methods, it is put into centrifuge tube, adds after the deutonymph of clean epidermis medicament is smashed to pieces
2ml ethyl acetate, is vortexed uniform 2 minutes, stands 10 minutes；Then 3000 revs/min centrifuge 10 minutes, take supernatant, addition contains
Anhydrous sodium sulfate and primary secondary amine（PSA）Centrifuge tube in, be vortexed uniform 10 seconds, 3000 revs/min centrifuge 10 points
Clock, membrane filtration is closely dry by supernatant concentration, and with 1ml ethyl acetate constant volumes, the pesticide concentration in sample is detected with GC.Often
Handle 3 repetitions.As a result it see the table below 1.
The infiltration capacity of each treatment agent of table 1
The above results are not difficult to find out that synergist N-380 can substantially increase Bifenazate and etoxazole compound penetrates evil mite body
The amount of table, infiltration capacity is 4.21 μ g, is far longer than infiltration capacity when addition NF-100 and penetrant t.But, synergist N-380
To the osmotic effect of comparison medicament cyflumetofen when adding NF-100, penetrant t compared with, substantially increase is not observed.
2nd, apple tetranychus are tested
For examination evil mite be apple tetranychus (Panonychusulmi)
Remaining test method is tested with citrus tetranychid.As a result 2 be see the table below.
The infiltration capacity of each treatment agent of table 2
The above results are not difficult to find out that synergist N-380 can substantially increase Bifenazate and etoxazole compound penetrates evil mite body
The amount of table, infiltration capacity is 3.95 μ g, is far longer than infiltration capacity when addition NF-100 and penetrant t.But, synergist N-380
To the osmotic effect of comparison medicament cyflumetofen when adding NF-100, penetrant t compared with, substantially increase is not observed.
Examples detailed above is only that the present invention is explained further, and is not limitation of the invention, by by above-mentioned side
Case carries out simply adjusting the scheme obtained from, equally within the protection domain of the application.
Claims (9)
1. a kind of agricultural synergist and Bifenazate, the mixture of etoxazole compound mixture, it is characterised in that
The agricultural synergist is N-380；
The Bifenazate and the compound of etoxazole are acaricide；
The agricultural synergist is 1 with the acaricidal weight ratio:0.5-30；
The weight ratio of the Bifenazate and etoxazole is 1:8-50.
2. mixture according to claim 1, it is characterised in that the agricultural synergist and the acaricidal weight ratio
For 1:1-25.
3. mixture according to claim 1, it is characterised in that the agricultural synergist and the acaricidal weight ratio
For 1:5-9.
4. mixture according to claim 1, it is characterised in that the weight ratio of the Bifenazate and etoxazole is 1:
12-24。
5. mixture according to claim 1, it is characterised in that the weight ratio of the Bifenazate and etoxazole is 1:
15。
6. mixture according to claim 1, it is characterised in that also comprising agriculturally acceptable carrier and/or auxiliary agent,
It is prepared into and is agriculturally subjected to aqueous emulsion, microemulsion, missible oil, wettable powder, water dispersible granules, suspending agent.
7. a kind of agricultural synergist is used to increase the purposes that acaricide penetrates evil mite body surface, it is characterised in that
The agricultural synergist is N-380；
The acaricide is Bifenazate and the compound of etoxazole.
8. purposes according to claim 7, it is characterised in that the evil mite is plant evil mite, including T.urticae Koch
(Tetranychusurticae), citrus tetranychid (Panonychuscitri), coffee unguiculus mite (Oligonychuscoffee)、
Cotton spider mites (Tetranychustelarius), thorn apple rust mite (Aculusschlechtendali), panonychus ulmi
(Panonychusulmi), apple tetranychus (Panonychusulmi), Tetranychus cinnabarinus (Tetranychus cinnabarinus),
It is preferred that citrus tetranychid (Panonychuscitri) and apple tetranychus (Panonychusulmi)。
9. the mixture described in claim any one of 1-6 is used for the application for preventing and treating Agricultural Mites.
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| CN107136062B (en) | 2020-10-16 |
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Denomination of invention: A mixture of agricultural synergist mixed with biphenylhydrazide ester and imidacloprid complex and its preparation and application Effective date of registration: 20231218 Granted publication date: 20201016 Pledgee: Bank of China Limited by Share Ltd. Guilin branch Pledgor: GUILIN JIQI BIOCHEMISTRY CO.,LTD. Registration number: Y2023980072510 |