CN107106293A

CN107106293A - Modulability intraocular lens

Info

Publication number: CN107106293A
Application number: CN201580057973.1A
Authority: CN
Inventors: A·萨拉希; 克劳迪奥·R·阿尔真托; T·索尔; 鲍勃·沃恩; 埃里克·威利斯; 阿里·萨拉希
Original assignee: SHIFAMED LLC
Current assignee: SHIFAMED LLC; Shifamed Holdings LLC
Priority date: 2014-08-26
Filing date: 2015-08-26
Publication date: 2017-08-29
Anticipated expiration: 2035-08-26
Also published as: JP6267832B2; JP2017525525A; AU2015306613B2; CA2959354C; US10736734B2; US20200397566A1; US11583390B2; WO2016033217A1; CN110279494B; EP3185818A1; CA2959354A1; US20190159890A1; AU2015306613A1; CN110279494A; EP3185818A4; CN107106293B; US20230263620A1; CA3008944A1; CA3008944C

Abstract

Modulability intraocular lens (AIOL) for being implanted in the pouch of patient's eye include being linked together to define the first component and second component of inner-fluid chamber and external fluid storage chamber.AIOL interior zone provides focal power with one or more of shape of the forming fluid or first component of internal flow intracavitary or second component.Fluid storage chamber includes corrugated part region, and wherein one or more folding parts of corrugated part circumferentially extend around the optical axis of eyes.When eyes regulation is near vision, corrugated part engagement lens capsule, and internally the submissive fold domain between corrugated part part and outer corrugations portion part allows AIOL profile to bend.When eyes are adjusted, fluid internally shifts to provide power variation between fluid cavity and external fluid storage chamber.

Description

Modulability intraocular lens

Cross reference

This application claims the rights and interests for the U.S. Provisional Application No. 62/042,195 submitted for 26th in August in 2014, the Shen It please be incorporated herein by reference.

The theme of the application can be related to entitled " the ACCOMODATING INTRA submitted on March 13rd, 2014 OCULAR LENS " No. PCT/US2014/026817 [attorney of PCT application：44612-703.601], the PCT Application requires following priority application：Entitled " the Hydrophilic AIOL with submitted on 2 14th, 2014 Bonding " No. 14/181,145 (attorney of U.S.'s non-provisional application：44612-703.201]；In April, 2013 Entitled " the ACCOMODATING INTRA OCULAR LENS " U.S. Provisional Application No. 61/785,711 submitted for 30th [act on behalf of everybody Reference Number 44612-703.103]；Entitled " the AIOL WITH CAPSULE submitted on March 21st, 2013 FORMED HAPTIC " No. 61/804,157 (attorney of U.S. Provisional Application No.：44612-703.104]；2013 Entitled " the AIOL HIGH MOLECULAR WEIGHT REFRACTIVE INDEX MODIFIERS " U.S. submitted April 8 No. 61/809,652 (attorney docket of state's provisional application：44612-703.105]；That submitted May 29 within 2013 is entitled " ACCOMODATING INTRA OCULAR LENS " No. 61/828,651 [attorney docket of U.S. Provisional Application No.： 44612-703.106]；And entitled " the ACCOMODATING INTRA OCULAR LENS " that September in 2013 is submitted on the 24th No. 61/881,870 (attorney docket of U.S. Provisional Application No.：44612-703.107]；The complete disclosure of these applications It is incorporated herein by reference.

Background

This disclosure relates to Medical Devices and method.Especially, this disclosure relates to modulability intraocular lens (accommodating intraocular lens) (hereinafter referred to as " AIOL ").

Due to natural lens muddiness and cause visual loss, cataract can influence the very big of whole world Adult Groups Ratio.Cataract patient can be treated by removing the intraocular lens (IOL) of natural lens and Srgery grafting synthesis. In worldwide, millions of IOL implant surgeries are carried out every year.In the U.S., 3,500,000 cataract operations have been carried out, and it is complete The world has carried out the cataract operation more than 20,000,000 times every year.

Although IOL implantation can effectively recover eyesight, at least some cases, existing IOL is provided less Preferable result.Many existing IOL can not change focal length (being referred to as modulability) as natural lens.In addition, receiving existing The eyes for having AIOL may have at least some ametropia after the implantation so that glasses can be helpful to distance vision.Although Existing IOL can effectively provide good distant vision, but in many cases, be needed for middle eyesight and near vision patient Wearing spectacles.Although having been proposed solving the existing multifocal IOL of this shortcoming, existing multifocal IOL may not It is too preferable.Although multifocal IOL is good with distance vision performance generally for reading, at least some cases, existing Multifocal IOL may cause serious dazzle, halation and visual artifact at least some cases.

Although having proposed modulability IOL to provide modulability focal power in response to the distance of patient view's object (accommodative optical power), but existing AIOL may be not ideal at least some aspects.For example, existing Some AIOL may be provided less than preferable regulated quantity after the implantation, and may provide the preferable correction of refractive errors less than eyes. In addition, at least some cases, existing AIOL regulated quantity after the implants may reduction.At least some existing AIOL can Perfect condition when can be than being inserted by the otch of eyes is slightly larger, and otch may be needed more slightly larger than perfect condition.In addition, having The work for closing embodiment shows that at least some cases, compared with ideal situation, at least some existing AIOL are being placed on May be somewhat unstable when in eyes.

Overcome the improved implantable intraocular lens of the natural focusing response of the utilization eyes of at least some drawbacks described above To be desired.It is desirable that this improved AIOL will provide increased regulated quantity there is provided Myopia in implantation, draw Enter seldom (if any) perceptible visual artifact, and allow the focal power of eyes in response to the object of patient view Distance change from far vision (far vision) near vision (near vision).

General introduction

The embodiment of the disclosure provides improved AIOL method and apparatus.In many embodiments, AIOL includes interior Portion's fluid storage chamber and the external fluid storage chamber continuously set around internal flow storage chamber.AIOL interior zone, including internal stream There is provided focal power for body storage chamber.External fluid storage chamber can include the corrugated part region for being fluidly coupled to lens capsule (bellows region).AIOL provides focal power regulation in one or more ways.When eyes regulation is near vision, The submissive fold domain (compliant fold region) in corrugated part region can allow the profile of AIOL interior zone to scratch It is bent.When eyes are adjusted, corrugated part region allows fluid internally to be shifted between fluid cavity and external fluid storage chamber, to provide light Focal power changes.The internally periphery of fluid cavity, such as post or projection it is multiple protuberance can be in the first lenticular unit and second Between lenticular unit provide scheduled volume interval, and internally can be defined between fluid cavity and external fluid storage chamber one or Multiple fluid passages.Although corrugated part can be configured in many ways, in many embodiments, corrugated part surrounds lens Optical axis it is continuous and extend circumferentially over upon, wherein one or more folding parts of the opposite side of corrugated part are along the side similar to optical axis To extending towards one another.The folding part of corrugated part can be continuous generally surround optical axis and extended circumferentially over upon, and for example can be with Extend 360 (360) degree around optical axis.

The aspect of the disclosure provides a kind of modulability intraocular lens for being used to be placed in the lens capsule of subject. Modulability intraocular lens can include the first component with the first lens area and the first corrugated part region, and with the Two lens areas and the second component in the second corrugated part region, second component are connected to first component.Fluid cavity can be first Between lens area and the second lens area.Fluid storage chamber can between the first corrugated part region and the second corrugated part region, Wherein fluid storage chamber and fluid cavity are in fluid communication, with the alteration of form in response to lens capsule fluid cavity and fluid storage chamber it Between transfering fluid with for modulability intraocular lens provide focal power change.

In many embodiments, the first lenticular unit is adhered to the second lenticular unit in joint.Projection can position In on the inner surface of one or more of first component or the second lenticular unit, to be carried between first component and second component For gap.First lenticular unit can be adhered to around the joint of the first lenticular unit and the circumferentially extending of the second lenticular unit Second lenticular unit.

First corrugated part region can continuously circumferentially extend around the first lens area, and the second corrugated part region can enclose Continuously circumferentially extended around the second lens area.

First corrugated part region can include one or many continuously circumferentially extended around the optical axis of the first lens area Individual folding part, and the second corrugated part region can be including surrounding one that the optical axis of the second lens area continuously circumferentially extends Or multiple folding parts.

First corrugated part region can include for extending internally and continuously extending circumferentially over upon around the first lens area One one or more folding parts, and the second corrugated part region include extended internally around the second lens area and continuously circumference Second one or more folding parts of extension, first one or more folding parts and second one or more folding parts towards that This extension.

First component can include rigid first annular rigid attachment structure (annularly shaped stiff Coupling structure), first annular rigid attachment structure is all between the first lens area and the first corrugated part region To extension, to suppress the first lens area moving radially and move radially with the first corrugated part region.Second component can be with Including the second annular rigid attachment structure, the second annular rigid attachment structure is in the second lens area and the second corrugated part region Between circumferentially extend to suppress the second lens area moving radially and move radially with the second corrugated part region.It is first annular Structure can include the first radial thickness of the first thickness more than the first corrugated part region, and the second loop configuration can be wrapped Include the second radial thickness of the second thickness more than the second corrugated part region.

First lens area can include front lenses region, and the second lens area can include posterior lens portion Part.First lens area can include the first plane institution movement, and the second lens area can include the second plane institution movement.First One or more of part or second component can include shell (shell), such as non-flat face-piece.First component or second component In one can include in plane institution movement, and first component or second component another can include being shaped to provide Jiao The plano-convex component (plano-convex member) of degree.

Fluid in fluid cavity shapes fluid cavity, to provide focal power.The focal power of modulability intraocular lens changes The change for the focal power that the flow profile in fluid cavity is provided can be included.The light focus that flow profile in fluid cavity is provided The change for changing the shape that can include fluid cavity of degree.The focal power of modulability intraocular lens changes can be saturating including first The change of spacing distance between mirror region and the second lens area.

The edge of first lens area and the second lens area peripheral and radially inner prominent from corrugated part region Going out portion can overlap each other and can be bonded to each other.

Submissive fold domain between the includable portion's corrugated part of fluid storage chamber and outer corrugations portion.Submissive region can With thinner than inner corrugations and outer corrugations portion.In response to the flexure of the submissive fold domain of fluid storage chamber, lens cavity can be Deflection.Submissive region can be than being located at the inner corrugations part of fold domain radially inwardly and radially outwardly and outer respectively Portion corrugated part part is thinner.

Modulability intraocular lens can also include multiple protruding portion, such as one or more projections or post are the plurality of prominent Go out portion and be connected to one or more of the first lenticular unit or the second lenticular unit, and the first lenticular unit and the second lens Part can be separated each other.The plurality of protuberance can be along the outer of the interior section of the first lenticular unit and the second lenticular unit Edge is set.Multiple protruding portion can define multiple fluid passages, each fluid passage circle between fluid cavity and fluid storage chamber Two adjacent protrusions are scheduled on, such as between post or projection.

Protuberance can be located between corrugated part region and lens area, and the first lenticular unit is connected into the second lens section Part.Protuberance can be located at one or more rigid attachments of one or more of the first lenticular unit or the second lenticular unit In structure, to provide gap between first component and second component, and define around protuberance and between chamber and storage chamber Multiple passages of extension by storage chamber to be fluidly coupled to chamber.

In many embodiments, fluid storage chamber includes soft between internal corrugated part region and outer corrugations portion region Along fold domain, the submissive region is thinner than inner corrugations and outer corrugations portion.

In many embodiments, multiple protruding portion be connected to first component or second component and by the first lenticular unit and Second lenticular unit is separated each other.Multiple protruding portion can be arranged between corrugated part region and lens area, and multiple prominent Each that goes out portion and can be defined between fluid cavity and fluid storage chamber in multiple fluid passages, plurality of fluid passage is defined Between two adjacent posts.

One or more of first lenticular unit or the second lenticular unit can include the polymerization of such as PMMA copolymers Material.Polymeric material can be permeable.Polymeric material can be hydrophilic.When modulability intraocular lens are placed on crystalline substance When in shape somatocyst, the water in the lens capsule of subject can be transferred in fluid cavity or fluid storage chamber through polymeric material It is one or more or be transferred out from one or more of fluid cavity or fluid storage chamber, to realize osmotic equilibrium.For example, polymerization Thing material can be impermeable to the compound for being more than 40kDa with molecular weight.Modulability intraocular lens can also be wrapped Include the fluid in fluid cavity.Fluid can include solution, oil, silicone oil, dextran solution, high-molecular-weight dextran solution or other One or more in the solution of high-molecular weight compounds.

In many embodiments, fluid storage chamber includes the continuous baffle arrangement set around the periphery of fluid cavity.The company Continuous structure can include the one or more in annular, ellipse or non-rotational symmetric shape.

In many embodiments, first component and second component are sufficiently flexible to be reduced with being folded into cross section Delivering configuration.The delivering configuration that cross section reduces includes the optical axis surrounded transverse to modulability intraocular lens of intraocular lens Delivering axis one or more folding parts or rolling volume portion.Modulability intraocular lens can include delivery tube or hole, and The delivering configuration that cross section reduces includes the intraocular lens being advanced in delivery tube or hole.

In many embodiments, fluid storage chamber includes the haptic configuration (haptic of engagement lens capsule structure)。

In many embodiments, the fluid in fluid cavity has about 1.336 refractive index of the aqueous humor more than eyes Refractive index.

In many embodiments, the first lens area or the second lens area do not provide focal power.

In many embodiments, the fluid in fluid cavity provides focal power.

In many embodiments, the first lenticular unit and the second lenticular unit are bonded to each other.

In many embodiments, the first lenticular unit and the second lenticular unit include polymeric material, and first saturating Mirror element and the second lenticular unit are combined by the prepolymer of polymeric material.

In many embodiments, one or more of the first lenticular unit or the second lenticular unit are directly made Make, for example, printed by three-dimensional (3D).

In many embodiments, the first lenticular unit and the second lenticular unit have been manufactured directly together and wrapped Include single workpiece.

In many embodiments, the first lenticular unit and the second lenticular unit are individually moulded and are combined Together.

In many embodiments, the first lenticular unit and the second lenticular unit by individually lathe process and are tied It is combined.

In many embodiments, the first lenticular unit and the second lenticular unit prolong between first component and second component It is combined together at the protuberance stretched.

In many embodiments, the first lenticular unit includes the first manufacture parts, and the second lenticular unit includes second Manufacture parts.

The aspect of the disclosure provides the method for providing regulation for the eyes of subject.The pressure of change from lens capsule Contracting power is received by the external fluid storage chamber for the modulability intraocular lens being placed in the lens capsule of eyes.In response to receiving Change compression stress, fluid modulability intraocular lens inner-fluid chamber and external fluid storage chamber corrugated part region it Between promoted, corrugated part region is included around the folding part that continuously circumferentially extends of optical axis of intraocular lens.Inner-fluid chamber Size or one or more of shape in response to being pushed to the fluid of internal flow intracavitary or releasing inner-fluid chamber Fluid and change, to change the focal power of modulability intraocular lens.

In many embodiments, inner corrugations region and outer corrugations portion region are in fluid communication with each other and flowed with inside Body cavity is in fluid communication.One or more of corrugated part region can be annular, oval or rotationally symmetrical shape.

In many embodiments, fluid storage chamber includes the haptic configuration of engagement lens capsule.

In many embodiments, changing one or more of size or shape of inner-fluid chamber includes changing first Spacing distance between the part of lens area and the second lens area.

In many embodiments, change one or more of size or shape of inner-fluid chamber to define including change The radius of curvature of one or more of the first lens area or the second lens area of inner-fluid chamber.

In many embodiments, modulability intraocular lens include the first lens area and for defining inner-fluid chamber Two lens areas, and one or more of the first lens area or the second lens area are artificial to modulability including being configured to Crystalline lens provides the plano-convex component of minimum power.

In many embodiments, inner-fluid chamber includes fluid therein, and inner-fluid chamber provides shape for fluid Shape so that fluid provides focal power for modulability intraocular lens.

In many embodiments, the compression stress of increase change promotes fluid to enter in inner-fluid chamber.

The embodiment of the disclosure provides improved AIOL method and apparatus.In many embodiments, AIOL includes light Structure is learned, optical texture includes the rigid member and deflection component for being connected to haptic configuration so that rigid member and deflection Component substantially defines AIOL chamber.AIOL chamber includes the fluid of the refractive index of the aqueous humor with more than eyes so that Deflection component defines the convex curved surface of chamber fluid, to provide the fluid lens (fluid with adjustable focal power lens).Deflection component and rigid member are connected to haptic configuration, so as to when eyes regulation near vision when, deflection The profile of component and fluid lens deflects into convex bending profile.In many embodiments, when pouch is moved inward and eye When eyeball regulation is near vision, haptic configuration rotates relative to rigid member, to provide inward force for deflection component. Haptic configuration can include the pouch bonding part for being configured to receive the bending of pouch.Haptic configuration can join at first area It is connected to rigid member, and deflection component can be connected at the second area between first area and bag bonding part, makes Pouch power can increase due to leverage with the exterior section for deformable member provides increase amount inwardly Power.In many embodiments, deflection component is configured to amplify the inside motion of the exterior section of deflection component so that when When eyes are adjusted, the interior section of deflection component is inwardly moved away from rigid member movement more than the exterior section of periphery It is dynamic.This amplification of the motion of the interior section of deflection component and the corresponding increase of curvature add the capsule power of haptics The leverage of (capsular force) can provide AIOL improved regulation.

In many embodiments, the arrangement of rigid member, deflection component and rotation haptics can be with inward force Make deflection deflection so that the fluid of decrement can be used together with AIOL with the incision size reduced.In many realities Apply in scheme, rigid member, the arrangement of deflection component and rotation haptics can be with inward force without the stream of lens cavity Body pressure and make deflection deflection, and at least some embodiments, the arrangement can be with the negative pressure of chamber for can Deflection component provides convex curvature.In many embodiments, it is defined at least in part with deflection component and rigid member Chamber receives fluid from the exterior section of the chamber below the exterior section of deflection component so that the amount for the fluid being contained in AIOL And insertion profile can reduce.

Optical texture can in many ways in one or more provided to configure increase amount regulation.Deflection Component can include internal opticses correction portion and outer extension part, to provide between internal opticses part and haptic Curvature transition.The exterior section of back-flexing can reduce the diameter of optical correction part, be concentrated on so as to which focal power is changed In interior section.When eyes regulation is near vision, interior section includes the curved surface of outside convex with chamber Fluid provides focal power, and extension includes the concave curvature opposite with the curvature of interior section.The extension of back-flexing can To reduce the size in interior lights area so that focal power and the curvature increase provided with deflection component.The inside of deflection component Partial outer surface can convexly be bent, bent to spill or be generally flat for far vision, and when flexure To during regulating allocation near vision including bigger positive camber.The outer surface of exterior section can be bow or big It is flat for far vision on body, and when flexure is to the regulating allocation for being used near vision including bigger negative cruvature.Can The interior section of deflection component and the inner surface of exterior section can similarly be bent.In many embodiments, deflection structure Part includes generally uniform thickness.Alternatively, exterior section can include the thickness of the reduction relative to interior section, and can With including the outer surface with recessed profile, to promote the convex curvature of interior section when applying inward force using haptics. Exterior section can be sized so that at least a portion of exterior section is covered by pupil, so as to when interior section is including convex When curvature and exterior section include concave curvature, aberration can be suppressed.

In many embodiments, rigid member includes the lens of such as planoconvex spotlight, and the lens, which have, is configured to treatment The focal power of the far vision of patient.When eyes are adjusted, deflectable portion provides the extra focal power near vision.Permitted In many embodiments, the diameter of the lens of rigid member corresponds to the diameter of the interior section of deflection component so that rigid structure The diameter of the lens of part is dimensioned the exterior section less than deflection component, so as to but when reduce AIOL when inserting in eyes Thickness profile.

In many embodiments, the first lenticular unit and second that modulability IOL is constituted including each free polymer are saturating Mirror element, and the adhesive comprising polymer.Alternatively or in combination, first component can with such as interlocking joint, screw thread, The mechanical attachment of installed part or fastener is fixed to second component.In many embodiments, polymer can be hydrated and adjoint Hydration expansion so that first component, second component and adhesive expand (for example, with identical or substantially similar speed) together. By expanding together, it can substantially suppress the stress between first component, second component and adhesive.In addition, can be hydrated Adhesive allows before first component and second component are bonded together, and first component and second component be not with rigid complete Full hydrated configuration is machined.Rigid arrangement can include incompletely hydrated polymer, and that for example generally dries is poly- Compound.Part can be combined together with substantially rigid configuration, in order to the processing during making, and be then hydrated, and be made The part that adhesive must be combined includes the soft water conjunction configuration being used to insert in eyes.Adhesive comprising polymer can be by first Lenticular unit and the second lenticular unit, which are used, is similar to polymeric material being chemically bound together in itself, increased strong to provide Degree.

On the one hand, intraocular lens includes optical texture and haptic configuration with focal power.Optical texture includes can Deflection component, rigid member and the fluid cavity defined at least partially with rigid member and deflection component.Haptic configuration has Internal structure of the external structure to engage the capsule of eyes He be connected to deflection component, with haptic configuration relative to rigid member Increase the curvature of deflection component during rotation.

In many embodiments, deflection component is bent to the second profile from the first profile, wherein the second profile compares the One profile is more curved.Chamber includes the fluid with the refractive index more than 1.33 so that the chamber is matched somebody with somebody in deflection component in first Include the focal power of the first amount in the case of putting, and include the second amount in the case where deflection component is in the second configuration Focal power, and the second amount of focal power is more than the first amount.

In many embodiments, flexible structure includes internal opticses part and outer extension part.Rigid member, touch The curvature that feel portion and deflection component may be disposed so that internal opticses part to increase moves away from rigid member, and outside Portion's extension is moved with opposite curvature towards rigid member, to provide the focal power of increase.Internal opticses are partially away from firm The movement of property component and the movement of outer extension part towards rigid member can be by the chambers below fluid from outside extension Exterior section be transferred to internal opticses beneath portions chamber interior section so that fluid transfer reduce and can reduce The volume of AIOL fluid.

In many embodiments, the axis for rotating about the circumference for extending through haptic configuration occurs.It is artificial brilliant when inciting somebody to action When shape body is placed in eyes, for example, the circumference of haptic configuration can be in the plane transverse to the optical axis of eyes.

In many embodiments, haptic configuration can be included in first position and internally be anchored to rigid structure on end The cantilevered haptic configuration of part.Haptics can include the length for extending the distance from inner end to outer end.Tactile Structure can include thickness, and length can be more than thickness.Deflection component can separate a spacer with first position From the second place be connected to haptic configuration.Length can be more than the spacing distance, so as to when haptic configuration is relative to rigidity When component rotates, the internal opticses part of deflection component is separated with rigid member.

In many embodiments, rigid member includes one or more convexly curved optical surfaces.Rigid member can To extend to the thin section point being located near the outward flange of rigid member.Thin section point can define the pivot structure of anchoring, tactile knot Structure rotates around the pivot structure, when haptics rotates in response to the pressure of eye structure, inwardly to be promoted with radial load Deflection component.

In many embodiments, deflection component includes internal opticses part and is connected to the outside resilience of haptic configuration Property extension.Resilience extension can include the small thickness of thickness of the interior zone than deflection component.When resilience is prolonged When the internal opticses of deflection component point separates by extending portion partially away from rigid member, resilience extension can including with The opposite curvature of the curvature in internal opticses region.The inward flange of haptic configuration can be on the resilience extension of deformable member Apply radial load, it is one or more of following to carry out：Reduce the diameter in internal opticses region, or make resilience extension Bent relative to each other in opposite direction with the curvature in internal opticses region, so as in response to haptic configuration relative to rigid member Rotation, promote internal opticses region away from rigid member with the spherical flexure in internal opticses region and by the extension towards Rigid member is promoted.

In many embodiments, the reduction of the diameter of deflection component includes the rotation in response to haptic configuration, from the One diameter is to the transition of the Second bobbin diameter less than the first diameter, and the reduction of wherein diameter makes internal opticses partially away from rigid member Bend spherically and by the alteration of form of the chamber of fluid filling into more convex crooked outline, to increase the light focus of optical texture Degree.

In many embodiments, the convex bending profile of the chamber of fluid filling includes the volume of increase to change optics The focal power of structure.In response to the volume of increase, fluid can be from peripheral storage chamber be inhaled into chamber.

In many embodiments, haptic configuration makes the periphery of deflection component in response to pointing to radial load thereon The first distance is partially radially moved inward, and in response to the rotation of haptic configuration, the interior zone of deformable member can be remote Rigid member is more than the second distance of the first distance by promoting, to provide the amplification of the second movement relative to the first movement, And it is spheric profile to make deflection component forming.Deflection component can include general uniform and constant thickness to suppress abnormal Become.

In another aspect of the present disclosure, the method for regulation is provided including intraocular lens is placed on into eye for the eyes of patient In the lens capsule of eyeball.Intraocular lens can have optical texture and optics knot is connected at the perimeter of optical texture The haptic configuration of structure.It can rotate haptic configuration to change people at perimeter by the inward force in response to lens capsule The focal power of the lenticular optical texture of work.

In many embodiments, haptic configuration surrounds the axis rotation for the circumference for extending through haptic configuration.When by people When work crystalline lens is placed in eyes, for example, the circumference of haptic configuration can be in the plane transverse to the optical axis of eyes.Permitted In many embodiments, this method may be responsive to the rotation of haptic configuration, make at least a portion of optical texture relative Translated forward in the outward flange of haptic configuration.At least one of translation of optical texture can change the focal power of eyes.

In many embodiments, optical texture this at least partially can include deflection profile elements, this is flexible Bent profile elements include being connected to the perimeter of the inward flange of haptic configuration, interior zone and in haptic configuration and inner area Pivotal area between domain.The inward flange of haptic configuration can apply inward force on the perimeter of deflection component, with Carry out one or more of following：Reduce the diameter of the perimeter；Or in response to the rotation of haptic configuration, in pivot region Domain Chu Shi perimeters and interior zone are pivoted relative to each other, so that interior zone bends to change tactile away from rigid member Feel power.The pivot of the reduction and the perimeter of deflection component and interior zone of the diameter of deflection component relative to each other One or more of shape or volume of the chamber of fluid filling can be changed, to change the focal power of optical texture.Haptics Inward flange relative to inward flange can move the first distance in response to the radial load that is directed on inward flange；And this is flexible The interior zone of bent component can be bent bigger than first distance by the in response to the rotation of haptic configuration away from rigid member Two distances.

In another aspect of the present disclosure, there is provided a kind of intraocular lens.Intraocular lens can include optical texture, light Learn structure have focal power and including deflection component, rigid member and be defined at least in part deflection component and rigidity structure Fluid cavity between part.Intraocular lens can include haptic configuration, and haptic configuration is connected to the outer peripheral areas of rigid member, and And including the first lateral element, the second lateral element and be defined at least in part the first lateral element and the second lateral element it Between fluid storage chamber.Fluid storage chamber can be in fluid communication with one or more passages and fluid cavity.Haptic configuration can be configured Rotated at outer peripheral areas, and the second lateral element may be configured to inward force in response to lens capsule towards the Inwardly flexure is to reduce the volume of fluid storage chamber for one lateral element, to change focal power.In many embodiments, tactile knot Structure is configured to the axis rotation around the circumference for extending through haptic configuration.When intraocular lens is placed in eyes, example Such as, the circumference of haptic configuration can be in the plane transverse to the optical axis of eyes.In many embodiments, the second lateral element Can have perimeter and interior zone, and the pivotal area between perimeter and interior zone.Second outside member The perimeter of part and interior zone can be pivoted relative to each other at pivotal area, so that the second lateral element direction first Lateral element is bent.In many embodiments, the volume of fluid cavity can increase in response to the reduction of the volume of fluid storage chamber It is changed focal power.The shape of the chamber of fluid filling can change in response to the increase of the volume of lens fluid chamber, so that Change focal power.The alteration of form of the chamber of fluid filling can include interior zone the scratching away from rigid member of deflection component The reduction of the radius of curvature of bent and deflection component.In many embodiments, the inward flange of haptic configuration can be in response to touching Feel structure rotation and mobile first distance, and deflection component interior zone can it is remote from rigid member flexure more than the The second distance of one distance is to change focal power.The alteration of form of fluid cavity can make the geometry of rigid member generally not Flexure.

In many embodiments, deflection component can include be connected to haptic configuration inward flange perimeter, Interior zone and the pivotal area between perimeter and interior zone.The inward flange of haptic configuration can be in deflection component Perimeter on apply inward force, it is one or more of following to carry out：Change the diameter of perimeter；Or response In the rotation of haptic configuration, perimeter and interior zone is set to be pivoted relative to each other at pivotal area, so that interior zone Bend to change the focal power of optical facilities away from rigid member.Deflection component and rigid member can be by haptic configuration branch Support, and can in response to haptic configuration outer end the second direction opposite with first direction rotation and in first party Translate together upwards.Deflection component can be located on the rear portion of optical texture, and rigid member can be located at eyes Optical texture front part on.When haptic configuration rotates in response to the inward force of lens capsule, deflection component can It is moved rearwards by relative to rigid member, to increase the curvature of deflection component.Haptic configuration can make rigid member and deflection Component is translated forward together so that the focal power of eyes with the increased curvature of deflection component, deflection component relative to In the translating forward of the flexure backward of rigid member and rigid member and deflection component each and increase.

This aspect of the disclosure can also be for example by providing and providing one kind using the intraocular lens provided The method for providing regulation for the eyes of patient.

In another aspect of the present disclosure, there is provided a kind of method that eyes for patient provide regulation.This method can be wrapped Include and intraocular lens is placed in the lens capsule of eyes.In response to the internal-direction-force of lens capsule, intraocular lens can be made The optical texture in intraocular lens outer part office haptic configuration rotation.Rotation can surround and extend through tactile knot The axis of the circumference of structure occurs.The component of optical texture can bend more curved profile in response to rotation, to change eye The focal power of eyeball.In response to the rotation, thus it is possible to vary the shape and volume of the fluid cavity of optical texture are to change focal power.Fluid The shape and volume of chamber can be by making optical texture one or more of front piece or back member flexure change, To increase radius of curvature.In response to rotation, optical texture can in the forward direction be translated relative to the outward flange of haptic configuration To change focal power.In many embodiments, the combination of such separation, flexure and translation can be combined, to change Focal power.

The method adjusted is provided at the another aspect of the disclosure there is provided a kind of eyes for patient.This method can be wrapped Include and intraocular lens is placed in the lens capsule of eyes.Intraocular lens can include optical texture and be connected to optics knot The haptic configuration of the outer peripheral areas of structure.It can change artificial by rotating the haptic configuration of intraocular lens at outer peripheral areas The focal power of lenticular optical texture, reduces the fluid storage chamber of haptic configuration with the inward force in response to lens capsule Volume.The rotation of the haptic configuration of intraocular lens can occur around the axis for the circumference for extending through haptic configuration.As general When intraocular lens is placed in eyes, for example, the circumference of haptic configuration can be in the plane transverse to the optical axis of eyes.Touch Feeling the fluid storage chamber of structure can be defined between the first outer member of haptic configuration and the second outer member at least in part. By making the second outer member inwardly be bent towards the first outer member in response to inward force, the body of fluid storage chamber can be reduced Product.The focal power of change optical texture may be responsive to the reduction of the volume of fluid storage chamber to increase the stream of optical texture The volume of body cavity.The volume that the focal power of change optical texture may further include the increase of the chamber in response to fluid filling is come Change the shape of the chamber of fluid filling.

In many embodiments, changing the shape of the chamber of fluid filling includes the inside of deflection component of optical texture The radius of curvature towards rigid member of flexure and deflection component of the region away from rigid member reduces.The chamber of fluid filling Shape can be further by the way that the interior zone of deflection component and perimeter be changed away from rigid member translation.Ring The first distance should can be moved in the rotation of haptic configuration, the inward flange of haptic configuration.The interior zone of deflection component can be with Bend the second distance more than the first distance to change focal power away from rigid member.The alteration of form of the chamber of fluid filling can be with Make the geometry of rigid member generally not deformed.When being placed in eyes, the deflection component of optical texture can position In on the rear portion of optical texture, and rigid member can be located on the front part of optical texture.Change optical texture Focal power can include when haptic configuration rotates in response to the inward force of lens capsule, relative to rigid member to reach Dynamic deflection component, to increase the curvature of deflection component so as to increase the focal power of eyes.Rigid member and deflection component It can translate forward to increase the focal power of eyes together with haptic configuration.The circumference of deflection component may be located remotely from rigid member Circumference separation, to increase ox-eyed focal power.In many embodiments, this flexure, translation can be applied in combination and divides From to increase ox-eyed focal power.

In another aspect of the present disclosure, intraocular lens includes optical texture, and optical texture includes back member, anterior structure The chamber of part and the fluid filling between back member and front piece.Intraocular lens can include haptic configuration, tactile Structure interlocks the outer peripheral areas of back member and front piece, with suppress fluid leak into fluid filling tactile intracavitary and it Outside.In many embodiments, interlock region can include fluid tight seal to suppress fluid leakage.Haptic configuration can have First side and the second side, the first side have one or more male members, and the second side has multiple female components.This or many Individual male member can pass through the outer peripheral areas of back member and front piece, to be received by one or more female components, So that outer peripheral areas is interlocked.The outer peripheral areas of back member and front piece can have one or more holes, one or more Component passes through one or more holes.The outer peripheral areas of one or more of back member or front piece can have by touching Feel that one or more female components of structure are received so that one or more male members of outer peripheral areas interlocking.Work as intraocular implants Can by the interlocking of the back member of haptic configuration and the outer peripheral areas of front piece when body carries out one or more of following To keep：Deform to change the focal power of optical texture；Or be folded into or roll be rolled into delivering configuration.

In another aspect of the present disclosure, there is provided a kind of intraocular lens.Intraocular lens includes optical texture, optics knot Structure includes the fluid filling of back member, front piece and the offer focal power between back member and front piece Chamber.

Intraocular lens can include the haptic configuration for being connected to optical texture.In the shape or volume of the chamber of fluid filling One or more radial loads that can be configured in response to being applied in haptic configuration and change.The shape of the chamber of fluid filling Or the change of one or more of volume can change the focal power of the chamber of fluid filling, while making by back member and front portion The focal power that component is provided does not change generally.

In another aspect of the present disclosure, there is provided the method that the eyes for patient provide regulation.This method can include will Intraocular lens is placed in the lens capsule of eyes.The shape or volume of the chamber of the fluid filling of intraocular lens can be changed One or more of, with the focal power for the chamber for changing fluid filling, while making the light by back member and front piece offer Focal power does not change generally.

At the another aspect of the disclosure, there is provided a kind of intraocular lens.Intraocular lens can include being used to be placed on Optical texture in eyes.

In another aspect of the present disclosure, there is provided a kind of method.This method can include optical texture being placed on eyes In.

In many embodiments, there is deflection optical component as described herein flexure generally to keep light simultaneously The thickness of component is learned, to suppress the advantage of optical aberration when deflection.

An aspect of this disclosure provides a kind of intraocular lens for being used to be implanted into the lens capsule of patient's eye.People Work crystalline lens can include optical texture and haptic configuration.Optical texture can have periphery, and can include plane Component, the stream for being connected at periphery the plano-convex component of plane institution movement and being defined between the peaceful male member of plane institution movement Bulk optical element.Fluid optical component can be included with any being similar in the material of the peaceful male member of composition plane institution movement The fluid of the refractive index of person or both.Haptic configuration can make the peaceful male member of plane institution movement in the outer part office of optical texture Connection.Haptic configuration can include the fluid storage chamber being in fluid communication with fluid optical component and outer for what is connected with lens capsule Closed structure.The alteration of form of lens capsule can cause the stereomutation of the fluid optical component of the deformation corresponding to plane institution movement Or it is one or more in alteration of form, to change the focal power of fluid optical component.For example, the alteration of form of lens capsule can be with Haptic configuration is caused to apply mechanical force on plane institution movement so that the deformation of member and the correspondingly light focus of change fluid optical component Degree.This deformation of plane institution movement may not cause the light for changing plane institution movement, plano-convex component or both in some cases (that is, changing for focal power can only by the alteration of form of fluid optical component or stereomutation and alternatively crystalline lens for focal power One or more of intracapsular change of front and back position of intraocular lens is provided.)

Tactile peripheral structure can be rigidly connected to the component of the general planar of optical texture so that tactile peripheral structure On the power being directed radially inward can make the component of substantitally planar away from plano-convex deflection, to change fluid optical component Focal power.Plane institution movement can anchor to structure along the rounded periphery part of plane institution movement.Plane institution movement is away from plano-convex component Flexure can provide spherical optics correction.Changing for the focal power of fluid optical component can include to the stream from haptic configuration Body storage chamber flows into or from the response of the transfer of the fluid of fluid optical component.

The power being applied in tactile fluid storage chamber can make the deformation of tactile fluid storage chamber change the light of fluid optical component Focal power.The power being applied in tactile fluid storage chamber can cause fluid to be transferred to or be transferred out of Flow Optical from tactile fluid storage chamber Element, so that tactile fluid storage chamber is reversibly deformed.

In many embodiments, the stereomutation of fluid optical component is provided by the fluid of tactile fluid storage chamber.Permitted In many embodiments, flowing in or out the fluid transfer of fluid optical component makes plano-convex component not deformed.Plano-convex component can be wrapped Rigid member is included, and plane institution movement can include deflection component.In these embodiments, fluid optical component can be carried For most of focal power of intraocular lens.Fluid in fluid optical component and in the fluid reservoir room of haptic configuration can have Refractive index more than or equal to 1.33.

Fluid in fluid optical component and in the fluid reservoir room of haptic configuration can include oil, such as silicone oil or such as high The solution of molecular weight dextran.Fluid can have suitable refractive index.High-molecular-weight dextran is configured with the conjunction more than 1.33 The osmotic pressure of suitable refractive index and the aqueous humor similar to eyes.High-molecular-weight dextran can have being averaged at least 40kDa Molecular weight, and mean molecule quantity can in the range of about 40kDa to about 2000kDa, wherein intermediate range have by Any one higher limit defined and lower limit in 40kDa, 70kDa, 100kDa, 1000kDa or 2000kDa.HMW Portugal Glycan can include the distribution of molecular weight, and the distribution of molecular weight can be narrow or wide.Because refractive index can be based on The weight of glucan per volume is determined, and osmotic pressure can be determined by the particles of solute number of every volume, so glucan The amount of mean molecule quantity and glucan can be used for dextran solution being configured to appropriate refractive index and osmotic pressure.

In many embodiments, haptic configuration is configured to make intraocular lens be oriented in the lens capsule of patient's eye Appropriate location.In many embodiments, haptic configuration includes anterior haptic configuration and rear portion haptic configuration, and anterior tactile Feel that structure and rear structure are linked together to define fluid storage chamber therebetween.In many embodiments, haptic configuration includes It is connected to the loop configuration of the outer peripheral areas of optical texture.Haptic configuration can be including being connected to the periphery of optical texture simultaneously It is distributed in multiple auricle structures on the periphery of optical texture.

Periphery can include multiple holes, and haptic configuration can be connected to periphery through multiple holes.This is more Individual hole can be substantially parallel to the optical axis orientation of intraocular lens.Alternatively or in combination, multiple holes can be transverse to artificial Lenticular optical axis orientation.Haptic configuration can include one or more posts or other structures, one or more posts or other Multiple holes that structure is used for through the periphery of optical texture are placed, and haptic configuration is connected into periphery.Alternatively Or in combination, optical texture can include being used for the post with the respective outer side edges in the hole in such as haptic configuration.

Intraocular lens can be that enough flexible deliverings to be folded into cross section reduction are configured.Can be by by people The cross section that work crystalline lens obtains intraocular lens around the delivering folded vertical with the optical axis of lens or rolling volume reduces Delivering configuration.Alternatively or in combination, artificial crystalline substance can be obtained by the way that intraocular lens is advanced through into delivery tube or hole The delivering configuration that the cross section of shape body reduces.

In many embodiments, when intraocular lens is placed in lens capsule, plane institution movement is located at plano-convex component Rear portion.

Another aspect of the present disclosure provides a kind of method that regulation is provided in the eyes of patient.It is possible, firstly, to provide Intraocular lens.The intraocular lens provided can include optical texture and haptic configuration with periphery.Optics knot Structure can be connected to the plano-convex component of plane institution movement including plane institution movement, at periphery and be defined in plane institution movement peace Fluid optical component between male member.Fluid optical component can include having being similar to composition plane institution movement and convexo-plane structure The fluid of the refractive index of either or both of the material between part.Fluid optical component can have focal power.Haptic configuration The peaceful male member of plane institution movement can be made to be linked together in the outer part office of optical texture.Haptic configuration can include and stream The fluid storage chamber that bulk optical element is in fluid communication and the peripheral structure for connecting with lens capsule.Second, intraocular lens can To be folded into the configuration of profile reduction.3rd, by the lens capsule of intraocular lens's implantation patient's eye of folding.Work as implantation When in lens capsule, the configuration that the intraocular lens of folding reduces from profile returns to active configuration.4th, optical texture or tactile Feeling one or more of structure can activated to cause the body of the fluid optical component corresponding to the deformation in plane institution movement One or more of product change or alteration of form, to change the focal power of fluid optical component.

One or more of optical texture or haptic configuration can be activated by being directed radially inward power in haptic configuration So that plane institution movement is deformed, so as to change the focal power of fluid optical component.Tactile peripheral structure can be rigidly coupled to light Learn the component of the general planar of structure.Changing for the focal power of fluid optical component can be with the fluid reservoir from haptic configuration Room flows in or out the fluid transfer of fluid optical component.The fluid for flowing in or out fluid optical component from tactile fluid cavity turns Shifting can bend plane institution movement, and convexo-plane component is not bent.In alternate embodiment, flowed into from tactile fluid cavity Or the fluid transfer of outflow fluid optical component can bend plane institution movement and can also alternatively make plano-convex deflection.

One or more of actuated optical structure and haptic configuration can be by applying force in tactile fluid storage chamber Activate so that tactile fluid storage chamber reversibly deforms to change the focal power of fluid optical component.

In many embodiments, the periphery of optical texture includes multiple holes, and haptic configuration is through the plurality of Back member and front piece are linked together by hole in the outer part office of optical texture.It is connected to multiple holes of periphery Haptic configuration can be kept generally when intraocular lens is folded and during the function of intraocular lens or operation The component of plane and the component of plano-convex are linked together.The optical axis that the plurality of hole can be substantially parallel to intraocular lens is determined To.The plurality of hole can be oriented transverse to the optical axis of intraocular lens.

Haptic configuration can include one or more posts, and one or more posts are used to place to touch through the plurality of hole Feel that structure is connected to outer peripheral areas.Alternatively or in combination, the periphery of optical texture can have one or more holes, touch One or more holes can be passed through by feeling one or more posts of structure, and optical texture and haptic configuration are linked together.

, can will artificial crystalline substance by making intraocular lens around the delivering folded vertical with the optical axis of lens or rolling volume Shape body is folded into the configuration of reduced profile.Alternatively or in combination, can by the way that intraocular lens is advanced through into delivery tube or hole So that intraocular lens to be folded into the configuration of reduced profile.

The intraocular lens of folding can be by allowing fluid present in the fluid and lens capsule of lens fluid intracavitary Reach osmotic equilibrium and be implanted in lens capsule.One or more of plane institution movement or convexo-plane component can be permeable To allow to reach osmotic equilibrium.In many embodiments, porous back member or front piece are to more than 40kDa's The compound of molecular weight is impermeable.

In many embodiments, one or more plane institution movements or plano-convex component have substantially no focal power.

On the other hand, embodiment provides a kind of method for making modulability intraocular lens.There is provided and include polymer The first lenticular unit.The second lenticular unit for including polymer is provided.First lenticular unit is adhesively bonded to second Lenticular unit.Adhesive can include the prepolymer of polymer.

In many embodiments, prepolymer cures are to extend between the first lenticular unit and the second lenticular unit First lenticular unit is attached to the second lenticular unit by polymer.

In many embodiments, when the polymer extended between first component and second component is by the first lens section When part is attached to the second lenticular unit, the first lenticular unit and the second lenticular unit each include rigid arrangement.

In many embodiments, the first lenticular unit is hydrated, and the adhesive of the second lenticular unit and solidification provides water Modulability intraocular lens close, soft.

In many embodiments, make the first lenticular unit, the second lenticular unit and adhesive hydration include part and The polymer of each in adhesive it is fully hydrated to implantation when polymer the corresponding hydration level of hydration level.

In many embodiments, the first lenticular unit, the second lenticular unit and solidification adhesive in each each Soft configuration including the rigid arrangement before hydration and during hydration, and wherein the first lenticular unit, the second lenticular unit and solid Each changed in adhesive is configured to the second configuration from first and extends substantially similar amount, to suppress adhesive and first The stress at linking part between component and second component.

Many embodiments also include provide polymeric material and shaped by polymeric material the first lenticular unit and Second lenticular unit.

In many embodiments, the turning on the first lenticular unit and each comfortable lathe of the second lenticular unit when rigidity, To shape the first lenticular unit and the second lenticular unit.

In many embodiments, the first lenticular unit and the second lenticular unit are molded.

In many embodiments, prepolymer comprising the monomer of polymer, oligomer, partially cured monomer, particle or One or more in nano particle.

In many embodiments, the first lenticular unit includes disk-shaped structure, and second component includes disk-shaped structure, and And wherein first component and second component define chamber when joined, wherein disk-shaped structure is on the opposite side of chamber.

In many embodiments, one or more of first component or second component include groove, and groove is set Size simultaneously is configured to receive relative part and wherein adhesive is placed on groove.

In many embodiments, one or more of first component or second component include loop configuration, ring junction Structure extends between disk-shaped structure and the second disk-shaped structure, to make the first disk-shaped structure separate and define with the second disk-shaped structure The side wall of chamber.

On the other hand, modulability intraocular lens include the first lenticular unit, the second lenticular unit and adhesive.First Lenticular unit includes polymeric material.Second lenticular unit includes polymeric material.The adhesive of solidification is included in first component Polymer between at least a portion of second component, to make the first lenticular unit be attached to the second lenticular unit and boundary Determine chamber.

In many embodiments, chamber includes optical element.

Many embodiments also include the fluid of intracavitary, and the fluid has about 1.336 folding of the aqueous humor more than eyes The refractive index of rate is penetrated, and wherein one or more of first component or second component are configured to deformation to increase modulability people The lenticular focal power of work.

Many embodiments also include one or more haptics, with the wall of the pouch that engages eyes and in response to pouch Wall shrink and increase one or more of the first lenticular unit or the second lenticular unit curvature, to increase modulability people The lenticular focal power of work.

Many embodiments also include fluid, and fluid includes solution, oil, silicone, oil, high molecular weight molecules or HMW One or more in the solution of glucan.

Many embodiments also include the seam comprising adhesive, and seam is along at least one of first component and second component Divide circumferentially extending.

In many embodiments, the first lenticular unit includes the first disk-shaped structure, and the second lenticular unit includes position In the second disk-shaped structure on the opposite side of chamber, and wherein loop configuration is between the first disk-shaped structure and the second disk-shaped structure Extension is so that the first disk-shaped structure separates with the second disk-shaped structure and defines chamber.

In many embodiments, intraocular lens includes the soft configuration of the rigid arrangement before implantation and implantation.

In many embodiments, the first lenticular unit includes the first disk shaped optical structure, the first disk shaped optical structure bag Include one or more of lens, meniscus, meniscus shaped lens, flat board, flat part, and wherein the second lens subassembly includes the Two disk shaped optical structures, the second disk shaped optical structure includes one in lens, meniscus, meniscus shaped lens, flat board or flat part It is individual or multiple.

The another aspect of the disclosure provides a kind of intraocular lens for being used to be implanted into the lens capsule of patient's eye.People Work crystalline lens can include optical texture and haptic configuration.Optical texture can have periphery, and can include rear portion Component, the front piece for being connected at periphery back member and the stream being defined between back member and front piece Bulk optical element.Fluid optical component can be included with any being similar in the material of composition back member and front piece The fluid of individual or both refractive index.Fluid optical component can have focal power.Haptic configuration can be in the outer of optical texture Enclose and couple back member and front piece at part.Haptic configuration can include the fluid reservoir being in fluid communication with fluid optical component Room and the peripheral structure for connecting with lens capsule.The alteration of form of lens capsule can cause and back member or anterior structure One or more of the stereomutation for deforming corresponding fluid optical component of one or more of part or alteration of form, To change the focal power of fluid optical component.One or more of back member or front piece of optical texture can be pair Water is permeable so that when intraocular lens is placed in lens capsule, be present in the water in the lens capsule of patient's eye Fluid lens chamber can be transferred into or is transferred out of through it, to realize that infiltration is flat with the fluid being present in lens capsule Weighing apparatus.According to many embodiments disclosed herein, the various features of intraocular lens can also be configured in many ways.

In another aspect of the present disclosure, there is provided implantable intraocular lens.Intraocular lens can include having fluid Material in the optical texture and fluid cavity of chamber.The material can include incompletely hydrated state.A part for optical texture It is configurable to provide water to fluid cavity when being placed in eyes, and suppresses material from fluid cavity leakage, to make material Fully it is hydrated and extends fluid cavity.

The disclosure another aspect there is provided by artificial lens be implanted into patient's eye lens capsule in method. This method can include the otch for making the intraocular lens comprising incompletely hydrated configuration be advanced through eyes.From lens capsule Water can be by least a portion of optical texture so that intraocular lens is fully hydrated.In many embodiments, can be with Material in the fluid cavity for the optical texture for suppressing intraocular lens is leaked from least a portion of optical texture, is simultaneously from crystalline substance The water of shape somatocyst passes through so that the material is fully hydrated.

It is incorporated by reference into

The all publications, patents and patent applications referred in this specification are incorporated herein by reference, its degree as Each individually publication, patent or patent application by especially and individually indicate be incorporated by reference into it is the same.

Brief description

The novel feature of present disclosure is specifically described in appended claims.By reference to elaborating to utilize the disclosure The described in detail below and accompanying drawing of the illustrative embodiment of content principle, will obtain the feature and advantage to present disclosure Be better understood from, in the accompanying drawings：

Fig. 1 illustrates the modulability intraocular lens system according to many embodiments；

Fig. 2 illustrates the lens support structure according to many embodiments and the side view of lens；

Fig. 3 illustrates the viewgraph of cross-section of the lens support structure according to many embodiments, the lens support structure bag Containing the lens using threaded engagement；

Fig. 4 illustrates the viewgraph of cross-section of the lens support structure according to many embodiments, the lens support structure bag Containing the lens connected using interference engagement；

Fig. 5 illustrates the AIOL according to many embodiments, and the half portion of wherein supporting construction and haptic configuration is included in Made in the AIOL first half and lower half and all by identical material；

Fig. 6 illustrates the AIOL according to many embodiments, and wherein haptic configuration and supporting construction is integral and matched somebody with somebody It is set to class anchor ring (toroid like) structure；

Fig. 7 illustrates the AIOL of Fig. 6 according to many embodiments variant, and it, which is included, helps to reduce delivering cross section Features；

Fig. 8 illustrates the AIOL according to many embodiments, and it includes the elastomer support structure filled with fluid, the stream Body can be hardened after delivering AIOL；

Fig. 9 A, Fig. 9 B and Fig. 9 C depict the alternative retractable Lens Support Agencies according to many embodiments；

Figure 10 to Figure 14 B illustrate the alternative AIOL structures according to many embodiments, and wherein AIOL is inserted into nature Connect in capsule and with natural capsule cause attachment regions by the semicircle anchor ring regional seal of capsule, and wherein semicircle annulus region with Fluid transfer between AIOL inside causes AIOL regulation to change；

Figure 10 depicts the AIOL with alternative haptic configuration according to many embodiments, wherein by that will include one The equatorial zone and Background Region of the lens capsule of individual optical element seal to form fluid cavity；

Figure 11 depicts the AIOL with alternative haptic configuration according to many embodiments, wherein by that will include two The equatorial zone and Background Region of the lens capsule of individual optical element seal to form fluid cavity；

Figure 12 depicts the AIOL with alternative haptic configuration according to many embodiments, wherein by that will include two The sealed film of equatorial zone and Background Region of the lens capsule of individual optical element forms fluid cavity；

Figure 13 depicts the AIOL with alternative haptic configuration according to many embodiments, wherein by film and passing through The equatorial zone of lens capsule comprising an optical element and Background Region sealing are formed into fluid cavity；

Figure 14 A illustrate the alternate embodiment after implantation AIOL according to many embodiments, and Figure 14 B scheme The AIOL installed after surgery according to many embodiments, the wherein equipment one of lens capsule with being installed are shown Causeization；

Figure 15 is depicted includes the optical texture of anterior face and posterior face according to many embodiments；

Figure 16 A illustrate the lens support structure that optical texture is connected to before combination according to many embodiments, with And Figure 16 B illustrate the final AIOL according to many embodiments, wherein the point being combined together is provided along circumference Sealing；

Figure 17 is illustrated with the addition of the opaque unit dam in alternative rear portion according to the AIOL to Figure 16 B of many embodiments Shape thing (posterior opacification cell dam) and anterior capsulorhexis supporting part；

Figure 18 depicts the alternative AIOL according to many embodiments；

Figure 19 depicts the alternative optical texture according to many embodiments；

Figure 20 is the top cross-sectional view of the AIOL comprising optical module depicted in figure 19；

Figure 21 A are Figure 20 AIOL view in transverse section；

Figure 21 B are the haptic configurations according to Figure 20-Figure 22 of many embodiments with being generated by the capsule structure of eyes The associated radial direction and pressure load of power under modelling view；

Figure 22 is the final AIOL components being made up of Figure 19-element depicted in figure 21 according to many embodiments View；

Figure 23 A and Figure 23 B illustrate the alternative AIOL embodiments and preparation method according to many embodiments；

Figure 24 depicts the alternative low profile with alternative haptics and supporting construction according to many embodiments AIOL；

Figure 25 A are the models of the regulation potentiality of the AIOL similar to Figure 24 according to many embodiments；

Figure 25 B and Figure 25 C show Figure 25 A AIOL perspective cross-sectional view；

Figure 26 shows the AIOL similar with Figure 25 A deformed model；

Figure 27 shows the model of Figure 24 AIOL regulation potentiality；

Figure 28 A show the perspective cross-sectional view of another AIOL according to many embodiments；

Figure 28 B show the model of Figure 28 A AIOL regulation potentiality；

Figure 29 shows the perspective cross-sectional view of the another AIOL according to many embodiments；

Figure 30 shows the lens associated with Figure 29 AIOL；

Figure 31 shows the model of the regulation potentiality of another AIOL according to many embodiments；

Figure 32 shows the model of the regulation potentiality according to another AIOL of many embodiments；

Figure 33 shows the schematic diagram of the regulation potentiality according to the AIOL of many embodiments；

Figure 34 A show the AIOL according to many embodiments；

Figure 34 B are shown such as the internal pressure of the AIOL chambers in Figure 34 B；

Figure 35 A show the AIOL according to many embodiments；

Figure 35 B are shown such as the internal pressure of the AIOL chambers in Figure 35；

The method that Figure 36 shows the making AIOL according to many embodiments；

Figure 37 shows deformation to provide the optical texture of focal power；

Figure 38 A show the AIOL according to embodiment, and wherein AIOL forefront part is in the forefront portion of haptics Point front portion, wherein AIOL deflection component is configured to the translational movement of haptics and in rotary moving and bend；

Figure 38 B show the inside cavity pressure of the load in response to the AIOL in such as Figure 38 A；

Figure 39 A show the perspective view of the intraocular lens according to embodiment；

Figure 39 B show the cross-sectional view of the intraocular lens of Figure 39 A according to embodiment；

Figure 40 A show the perspective view of the intraocular lens according to embodiment；

Figure 40 B show the cross-sectional view of the intraocular lens of Figure 40 A according to embodiment；

Figure 41 A show the cross-sectional view of the modulability intraocular lens according to embodiment；

Figure 41 B show the perspective view of the lenticular unit of Figure 41 A intraocular lens；With

Figure 41 C show the perspective view of the relative lens part of Figure 41 A intraocular lens；And

Figure 42 shows the cross-sectional view of the intraocular lens according to embodiment.

It is described in detail

AIOL as described herein may be used to provide improved eyesight, and can be with many known surgical operations And device, such as one or more combinations in cataract operation and intraocular lens inserter.AIOL optical texture is very It is suitable for calculating with the IOL focal powers of the commercially available biostatistics based on eyes and is used together, and can be used for Improved eyesight is provided.In many embodiments, doctor can be inserted in the mode similar to the IOL of existing non-regulated AIOL as described herein so that AIOL as described herein can be used easily.

AIOL as described herein structure can in many ways in one or more be combined to provide it is improved Modulability IOL.In many embodiments, AIOL includes the optical texture being made up of soft material, and wherein optical texture is connected to Haptics, for example to provide focal power with the natural force of the lens capsule of eyes as described herein.In many embodiment party In case, deflection component includes enough radial strengths so that the radially inner power to the exterior section of deflection component is led Cause the flexure of the interior section of deflection component.Flexure can include the reversible flexing of single order of such as deflection component.In many In embodiment, deflection member bends are into causing interior section to include the convex curvature along outer surface, and exterior section includes Along the relative convex curvature of outer surface.Convex interior section can include disc-like shape, and outside concave portions can include The annular shape of the neighbouring disc-like shape.The arrangement of the disc-like shape of convex and the annular shape of spill can be for example across flexible The diameter of bent component provides two flex points.

The deflection component radially extended can in many ways in one or more modes provided to configure radially Intensity, to make at least interior section for example be bent with regard to one or more of modulus of elasticity, thickness or diameter.

Deflection component can in many ways in one or more be connected to haptics, so as to when engaged crystalline lens Bent when the haptics of capsule is radially-inwardly promoted.In many embodiments, deflection component includes enough radial strengths, with When the exterior section of deflection component is urged radially inwardly or is rotated and is urged radially inwardly and rotation is combined, cause At least alteration of form of interior section.In many embodiments, deflection component is connected to lens capsule so that haptics phase Rotation for rigid member causes the exterior section of deflection component to move radially inwardly and rotate flexure.Alternatively or group Ground is closed, haptics can be arranged radially and slided relative to rigid member, inwardly to promote deflection with radial load Component, and bend the interior section of deflection component with the radial strength of exterior section.Deflection component can be included outside One or more structures of promotion flexure on portion part, the exterior section of such as spill or relatively thin annular region, to promote The spill flexure of such as exterior section and the convex of interior section are bent.

This disclosure relates to the equipment associated with improved modulability intraocular lens (AIOL), method and system.Some Embodiment will include central optical structure, and the central optical structure is made up of two deformable lens, and this two deformable What mirror was for example opened by the lens support structure concentric with the optical axis of lens along its optical axis interval.By lens and optional lens The volume that supporting construction is limited can be filled with solion (such as salt solution) or non-ionic solution (such as glucan or silicone oil).Light Learning structure can be limited by one or more haptic configurations again, the haptic configuration either fluid filling, or at another In embodiment, it is disposed in the plane of the optical axis of lens.Haptic configuration can be with the stream that is limited by optical texture Body is in fluid communication.Fluid transfer between haptic configuration and the optical texture of fluid filling can be by making one or two saturating Mirror deforms to change the regulation focal power (accommodating power) of lens.Alternatively or in combination, haptic configuration can be Directly apply mechanical force on the lens of the optical texture of fluid filling, to cause to deform and change regulation focal power.Improved regulation Property intraocular lens system can comprise additionally in any combinations of feature described herein.

Lens described herein and some supporting constructions will generally be made up of water wetted material, when hydrated, the hydrophilic material Material is optical clarity, and 10%, and strain level of the regulation more than 100% in hydration are expanded more than during hydration.The material It can be bought as disk and rod.For example, water wetted material can include hydroxyethyl methacrylate (HEMA) and methacrylic acid The copolymer of methyl esters (MMA), CI18, CI21 or the CI26 such as produced by Contamac Co., Ltds of Britain.These materials are at this PMMA also is indicated as in text, and as used herein, PMMA refers to include PMMA polymer or being total to comprising PMMA Polymers, such as PMMA polymer (hereinafter referred to as " poly- (methyl methacrylate) ") or HEMA and PMMA copolymer are (for example, all Such as p (HEMA-co-MMA)) in one or more.As it is used herein, p (HEMA-co-MMA) refers to HEMA's and PMMA Copolymer, and alternatively referred to as p (HEMA-MMA).

Copolymer can include block copolymer (PPPP-HHHH), alternate copolymer (PHPHPHPH), statistics or random common One or more in polymers (PHPPHPHH), radial copolymer, scopiform copolymer or graft copolymer, wherein for example " P " is marked Know " MMA ", and " H " mark " HEMA ".

In some embodiments, hydrogel AIOL part can be manufactured by 3D printing, be included but is not limited to following Any one in common 3D printing technique：Stereolithography (SLA), inkjet materials injection (IMJ), digital light processing (DLP), choosing Selecting property laser sintered (SLS), fusion sediment modeling or fuse manufacture (FDM/FFF).Such as SLA, IMJ and DLP method may It is particularly suitable for use in the AIOL elements that manufacture is made up of such as PMMA hydrogel and such as HEMA copolymer.Implement such In scheme, raw material can be monomer or oligomer precursor or its combination of aquogel polymer.It is described herein available for preparing A kind of AIOL such polymer can include pHEMA, wherein can be by the UV sources of appropriate wavelength and duration be come light Initiated polymerization.In some such embodiments, what can be mixed by adding with the monomer for printing is light-initiated Immunomodulator compounds are light-initiated to further enhance.Such light trigger can discharge related to the speed of polymerisation under irradiation Free radical.The light trigger of some selections is listed below.

In some embodiments, complete AIOL can be manufactured by 3D printing technique, and after completion is built Remove the unpolymerized material in inside configuration.Alternatively or in combination, the unpolymerized material in lens arrangement can be processed, and make Obtaining reactive terminal group becomes not react so that can not occur the further polymerization of the material.In other embodiments, AIOL Structure can be manufactured to the subassembly for assembling later, as described by elsewhere herein on machined components.

The positive camber of outer surface used herein covers convex curvature, and the negative cruvature of outer surface covers concave curvature.

As it is used herein, similar reference refers to similar structure.In many embodiments described herein In, reference includes three or 4-digit number, wherein first or front two numeral refer to the sequence number of accompanying drawing, and last two Refer to the similar structure in the figure with different sequence numbers.For example, to refer to Figure 25 respectively with 3303 similar with Figure 33's for reference 2503 Deflection component.It will be appreciated by those of ordinary skill in the art that the word of the structure of one figure of description is applied to as carried herein The similar structures of any other figure supplied.

In many embodiments, deflection component includes internal opticses part and outer extension part, to collect neutralization Focal power in amplification in opticator.Internal opticses part may be located remotely from rigid member movement with including providing increased light focus The outer surface of the convex bending of degree.In addition, exterior section can be bent towards rigid member, so as to including opposite curvature and court Moved to rigid member.The exterior section of back-flexing can reduce the diameter of optical correction part, so as to which focal power is changed Concentrate in interior section.The distance of the increase of the focal power of interior section and the centre-to-centre spacing rigid member of interior section and from Outer extensions assign to the distance dependent of the reduction of rigid member.The inside spacing distance of increase and the space outside distance reduced Combined effect has the effect of combination to increase focal power.Further, since power of lens can be generally by the straight of lens Square reduction in footpath, so the diameter of the reduction of the interior section set with the exterior section of local inclination can further increase Power of lens.

In some embodiments, intraocular lens/lens combination and/or define lens cavity or fluid optical component its Its part is higher than the water based transparent fluid of water filled with refractive index, to increase the focal power of system.The high folding of lens cavity liquid The rate of penetrating can be caused by the presence of solute.This solute generally comprises the macromolecular that cannot pass through the chamber for defining part.It is this big The example of molecule includes having example molecule amount<40kD、<70kD、<500kD and<1000kD glucan.This solute Other examples include glycan molecule.Solute and water can constitute the dilute solution with osmotic pressure.This osmotic pressure can cause water to enter Enter or leave the movement of chamber to realize osmotic equilibrium volume.Such volume, which can be enough to produce in systems, is suitable for patient institute Need the focal power of focal power.

Each in modulability IOL as described herein includes front side and rear side.The node of lens is preferably along saturating The optical axis of mirror is positioned at midpoint, and anterior face and posterior face of the midpoint along optical texture of the optical axis away from lens are substantially etc. Away from ground positioning.In many embodiments, the node of lens is located remotely from the plane extended between peripheral tactile lever construction, To define the front and rear direction of lens.Based on teachings disclosed herein, those of ordinary skill in the art can make before lens Rearwardly towards reversion.

The soft material of AIOL optical texture can in many ways in one or more shapings, and example can be included As machining part or moulding part with and combinations thereof.

Improved modulability intraocular lens can have the delivering cross section reduced.Can be by that can be configured from delivering The optical texture of operative configuration is converted to promote the delivering cross section reduced.Optical texture can have edge in delivering configuration The small size of optical axis, and there can be the larger size along optical axis in operative configuration.In addition, lens supports knot Structure can be configured to keep the distance between the periphery of two lens in operative configuration, and allow fluid in any configuration Pass through between haptic configuration and the fluid volume limited by optical texture.

Delivering cross section can be by obtaining around the delivering folded perpendicular to optical axis or rolling volume AIOL.Delivering is horizontal Section can be measured as the full-size delivered in configuration measured in the plane perpendicular to delivering axis.It is disclosed herein The available delivering cross sections of AIOL be smaller than 4.5mm, and preferably smaller than 2.5mm.In alternative embodiment, it can pass through AIOL is forced through pipe or delivery orifice to obtain delivering cross section.Such pipe can be conical on cross section so that AIOL can be compressed when it is travelled downwardly along pipe.Distal end can be dimensioned with the otch phase in eyes Connect.Delivering can be promoted by syringe or plunger.

Intraocular lens system can be made up of at least two hydrophily PMMA lens, wherein PMMA represent to include it is following in One or more compounds：Such as polymethyl methacrylate (PMMA), poly hydroxy ethyl acrylate (PHEMA), first Base hydroxy-ethyl acrylate (HEMA) or methyl methacrylate (MMA).Lens combination can include by any the one of following material Other elements of individual or any combinations composition：NiTi, polyurethane, hydrophily PMMA, light-activated polymers, PMMA precursors, second two Alcohol dimethylacrylate (EGDMA), siloxanes, silicone copolymers and other.

One or more of component or plano-convex component of substantitally planar can include polymeric material.Polymeric material can With including material obtained by the Vista Optics Co., Ltds for example from the Contamac Co., Ltds of Britain or Britain.Example Such as, PMMA copolymers can be from including following list selection：From obtained by Contamac Co., Ltds of Britain The materials of Definitive 50, the materials of Definitive 65, the materials of Definitive 74, Filcon V3 materials, Filcon V4 Material, Filcon V5 materials, Optimum Classic materials, Optimum Comfort materials, Optimum Extra materials, Optimum Extra16 materials, Optimum Extra 18.25mm materials, Optimum Extra 19mm materials, Optimum Extra 21mm materials, Optimum Extreme materials, F2 materials, F2Low materials, F2Mid materials, F2High materials, Focon III2 materials, Focon III3 materials, Focon III4 materials, Hybrid FS materials, Contaflex GM Advance materials, 49%Contaflex GM Advance materials, 58%Contaflex GM Advance materials, Filcon The materials of I 2, Filcon II2 materials, 49%Contaflex GM3 materials, 58%Contaflex GM3 materials, Contaflex Material, 58%Contaflex materials, 67%Contaflex materials, 75%Contaflex materials, 38%Polymacon materials, 45%Hefilcon materials, 55%Methafilcon materials, Filcon II materials, the materials of Filcon IV 2, HI56 materials, PMMA materials, CI26 materials, CI26Y materials, CI18 materials and other variants, and from the limited public affairs of Vista Optics of Britain The obtainable materials of Vistaflex GL 59 of department, HEMA/GMA materials, Advantage+49 materials, Advantage+59 materials, The materials of Filcon I 1, the materials of Filcon 12, VSO nVP materials, nVP/MMA materials, the materials of VSO 60, the materials of VSO 68, The materials of VSO 75, the materials of Filcon II 1, Filcon II2 materials, VSO pHEMA materials, pHEMA materials, HEMA materials, The materials of VSO 38, the materials of VSO 42, the materials of VSO 50, the transparent UV materials of Vistaflex 67, polysiloxanes-acrylate material Material, AddVALUE organic silicon acrylic esters material, the materials of AddVALUE 18, AddVALUE35 materials, poly- fluoro- silicon-acrylic acid Ester material, AddVALUE fluorine silica acrylic acids ester material, the materials of AddVALUE 25, the materials of AddVALUE 50, the materials of AddVALUE 75 Material, AddVALUE100 materials, sclera rigid gas permeable material, hydrophobicity artificial crystalline lens material, the transparent Tg of VOPhobic 16 materials, the materials of VOPhobic Yellow Tg 16, hydrophily artificial crystalline lens material, HEMA-MMA copolymer materials, IOSoft materials, IOSoft transparent materials, IOSoft yellow materials, PMMA materials, Vistacryl CQ UV materials, Vistacryl XL blue materials, Vistacryl CQ materials and other variants.Generally, polymeric material can be permeable With it is hydrophilic in one or more.When intraocular lens is placed in lens capsule, it is present in the crystalline of patient's eye Water in somatocyst can be transferred into or be transferred out of fluid optical component through polymeric material, to realize with existing in lens capsule Fluid osmotic equilibrium.Polymeric material can be impermeable to silicone oil.Polymeric material is to more than 40kDa's The compound of molecular weight can be impermeable.

In some embodiments, AIOL is inserted into natural intracapsular and connected with natural capsule so that connect region generation Sealing, the sealing forms the semicircle annulus region of capsule, wherein the fluid transfer between semicircle annulus region and AIOL inside is led The regulation in AIOL is caused to change.

In such embodiments, the fluid of such as salt solution can be injected into semicircle annulus region.

In some embodiments, optical texture is matched somebody with somebody after in the capsule for be introduced into eyes from delivering configuration change for operation The material composition put.A kind of such material can include light-activated polymers, and it is liquid in delivering configuration, and the liquid exists Hardened after introducing by photoactivation.Another such material can include the memory metal of such as NiTi alloys, and it is being passed Delivery has thin size in putting in the plane perpendicular to optical axis, and starts to change via inductively heating after pickup Become operative configuration.In other embodiments, NiTi can be transformed into operation by its super elastic characteristics from delivering configuration Configuration.

In some embodiments, optical texture is mechanically more more stable than in delivering configuration in operative configuration, and After in the capsule for be incorporated into eyes, spontaneously from configuration change is delivered into operative configuration.In this configuration, optical texture can Lured into becoming delivering configures before delivering or when making with just.A kind of such system can include superelastic metal Element, it is when equipment is introduced into capsule from delivering configuration suddenly change (spring).

In some embodiments, lens support structure and a lens are machined or molded as single structure, and And second lens by combination tool be fixed to supporting construction.In many other embodiments, AIOL is made up of two half-unit, Each half portion includes lens, and the two half-unit is combined together to form optical texture.Such embodiment can be comprising tactile Feel structure.In the other embodiments having again, the second machining operations can be performed in the structure of combination.Alternative knot Conjunction instrument can include the mechanical linking part of such as screw thread, and the periphery of wherein lens is threaded and supporting construction interior table Face is threaded.In alternative embodiment, linking part can be simple interference engagement.In some embodiments, Gu It is fixed to include handling the one or both in the mating surface of separation by using precursor monomer, the structure is then assembled, across combination Surface applies load, and component is heated a period of time to combine material.This process can promote to include two parts Crosslinking between material.In some cases, precursor monomer can be mixed with the little particle of polymer.Bonding agent can be comprised additionally in Polyurethane, siloxanes, epoxy resin, acrylic resin and other.

In the equipment of the disclosure, lens can be made up of water and ion-permeable material.In some embodiments, AIOL can allow filling certainly after implantation, so that delivering cross section is minimized.

In alternative embodiment, AIOL is filled after the implantation.

Fig. 1 illustrates modulability intraocular lens (AIOL) system or intraocular lens 10, and it is supported comprising center lens Only one in structure 11, two haptic configurations 12, two deflection lens 13 and two compression strap 14, two deflection lens It is visible in Fig. 1.Haptic configuration 12 can include the thin-walled knot for being configured to deform and be made up of elastomeric material under minimum load Structure.AIOL 10 internal volume can be filled with transparent fluid, such as with being oozed with fluid in eyes around lens capsule The salt solution of suitable osmotic pressure is pressed thoroughly.Alternatively, as described elsewhere herein, AIOL 10 can use the fluid of high index of refraction Filling.Lens 13 connect with supporting construction 11 so that when in fluid being transferred to the internal volume of supporting construction from haptics, lead Lens flexure is caused to adjust focal power so as to change it.

The side view of Fig. 1 lens support structure 11 is illustrated in fig. 2 together with two lens 13.Lens 13 can have Identical shape can have different shapes.It also can be seen that being included in lens support structure 11 in Fig. 2 is Haptic configuration connects feature 15.The open end of haptic configuration 12 is placed in haptic configuration and connected the top of feature 15, and uses Compression strap 14 is further secured to lens support structure and connected feature 15.In addition, in some embodiments, bonding can be used Agent or sealant, such as silicones.In alternative embodiment, press-fit can be used.In the other embodiments having again, Haptics 12 can be molded on tactile linking part.In one embodiment, haptics 12 is molded on PMMA barbs, PMMA barbs are then attached to supporting construction 11.The combination can be by adhesive or can be by promoting barb and branch Crosslinking between support structure, as herein discussed below.Material for haptic configuration 12 and haptic configuration linking part can With any one in the copolymer including siloxanes, PEBAX, carbamate, PMMA and siloxanes or other elastomeric materials Individual or any combinations.The distance between periphery of lens 13 can be kept by supporting construction 11, while when in supporting construction 11 Fluid volume increase when, it is allowed to the centre deflection of lens, so as to change the regulation focal power of the structure.In some embodiments In, haptic configuration 12 can be made up of extrusion molding.

Fig. 3 figures show one in lens support structure 31, two of which lens --- the first lens 36 are included in branch It is integral in support structure 31 or with supporting construction 31.The second lens in Fig. 3 embodiment --- lens 33 be configured to through Connected by screw thread 37 with supporting construction 31.Structure 35 stretches out lens body being connected to haptics.

Illustrated in another embodiment Fig. 4 of the central support structure similar with shown in Fig. 3.In the embodiment In, the second lens 43 are connected by interference engagement.In some embodiments, interference engagement can be by using sealant or viscous Mixture is further sealed.The interference is further promoted to match somebody with somebody by the process for assembling with rehydrated (rehydrate) part Close.The such process performed in supporting construction 41 as shown in FIG. 4 is as follows：Supporting construction 41 including lens 46 Bottom be hydrated, then the lens 43 in non-hydration status are arranged to including in the groove in supporting construction 41, branch Support structure 41 and lens 43 and 46 are allowed to fully be hydrated, and if desired, then apply sealant or adhesive.Use Interference engagement can minimize the demand of adhesive and/or the amount of adhesive.

Fig. 5 figures show AIOL 50 another embodiment, and the half of wherein supporting construction 51 and haptic configuration 52 includes In AIOL 50 first half and lower half, and thus all it is made up of identical material.The two half-unit is tied at seam 59 It is combined to form complete haptics and supporting construction 51.Lens 53 can be integral with half portion structure or be attached to Supporting construction 51.In production environment, it is allowed to which a lens are aligned after the remainder manufacture of structure and with reference to can be with The advantage for the optical axis Accurate align for ensuring two lens is provided.

In the embodiment shown in Fig. 1 and Fig. 2, haptic configuration 12 is configured by this way：They can with lens The vertical plane of optical axis in outward bending and away from supporting construction 11.This configuration, which can aid in reduction, is used for fluid filling The delivering cross section of equipment.In the embodiment shown in Fig. 6 and Fig. 7, haptic configuration and lens support structure are integral, and And continuously attached in the periphery of lens support structure.

The embodiment that Fig. 6 figures show AIOL 60, wherein haptic configuration 62 and supporting construction 61 be it is integral and by It is configured to class anchor ring structure.The inside radius of class anchor ring structure includes supporting construction 61.Fluid can be allowed to pass through opening 67 flow between the internal volume of haptic configuration 62 and supporting construction 61.Can be by combining two half-unit at seam 59 To manufacture AIOL 60.Lens 63 can be integral with half portion, individually be attached to half portion.

The modification of Fig. 6 embodiment figure 7 illustrates.AIOL 70 embodiment is horizontal comprising contributing to reduction to deliver The feature in section.The half portion of supporting construction can be included in each upper half and bottom half portion on AIOL 70, and can To be made up of a series of structures 71, this series of structure is each separated by space, so as to form castellation ring (castellated ring).Castellated structure is engaged before being combined at seam 79 in assembling.Ring spring 79 can be disposed in a groove, and Can relative to the displacement latch-up structure along optical axis upper half and bottom half portion.As shown in Figure 7, lens 73 can be with The half portion structure for constituting AIOL70 is integral.In other embodiments, lens 73 can be separated and and in knot of another time Close.In such embodiments, supporting construction can be bigger during delivering deformation because castellation element can be Folded in bigger radius of curvature.AIOL70 can also include features 78, and features 78 can allow during cohesive process Stressed mode is directly applied across seam 79.Surface including seam can comprise additionally in chamfering or fillet to guide combination Agent flow and minimize the possibility in generation space.

The embodiment that Fig. 8 represents AIOL 80, it includes elastomer support structure 81, and elastomer support structure 81 is filled Have can delivering AIOL after-hardening fluid.Such fluid can be photo-curable, and can include such as UV The pH curing liquids or curing fluid of constitutes of silicones or epoxy resin, such as collagen solution, the wherein material include feeling The suspension for the particle (such as magnetite ore particles) that should be heated.Passage 87 can allow fluid at the center of haptics and supporting construction Pass through between volume.

In alternative embodiment, AIOL80 supporting construction 81 can be matched somebody with somebody with the extension of the AIOL80 as shown in Fig. 9 A Supporting construction 91 shown in putting is substituted, or by including the supporting construction of channel design 87 as shown in Fig. 9 B, Fig. 9 C 98 are substituted, and supporting construction 98 can include memory metal, and the memory metal can be planarized with including such as Fig. 9 B in the pre-assembly Shown in planar configuration 99, then by inductively heating to allow it that operation as shown in Figure 9 C is presented after delivery Configuration.This configuration can provide the cross section of reduction.

Embodiments described here also allow to be ranked up component and using prolonged setting, heat, pressure and/ Or light-initiated jointing material is to ensure the appropriate optical alignment of lens.

By using EGDMA or triethylene glycol dimethacrylate (TEGDMA) processing mating surface, then make mating surface Withstanding pressure and temperature, can promote the combination of HEMA and MMA copolymers.Processing can include but is not limited to steam treated, profit It is wet, soak and allow the copolymer for evaporating, applying EGDMA or TEGDMA and hydroxyethyl methacrylate and methyl methacrylate Particle mixture.During as one kind, 40 microns of pearls of HEMA and MMA copolymer can mix simultaneously with EGDMA As bonding agent.This association schemes can provide advantage, because seam can be not present or there is minimum seam, and tie The mechanical performance of the linking part of conjunction has and structure identical mechanical performance.

Delivery process can change and by depending on the embodiment of equipment.Work is pre-filled with when generally making In a delivery process for making the AIOL that fluid and being ready for is used, equipment can be selected for size and basic regulation focal power Select to meet the demand of patient.Eyes can be ready to according to the standardization program for being typically used for instillation non-regulated lens, its In it is possible exception be that otch may be bigger in some embodiments.AIOL can be loaded into syringe, and then Inject in ready eye capsule.AIOL then can be with adjustment position.In alternative delivery process, it can fill brilliant in operation Shape body.During this, filling can include setting AIOL size and/or set AIOL basic focal power.In order to adapt to This process, equipment can include fill port, and the fill port can be before implantation sealable by combining, or Include the port of the self-sealing material of such as elastomeric material.

In another alternative, AIOL can be filled after the implantation, so that delivering cross section is minimized.Such In embodiment, after the implants, the equipment can be filled via foregoing fill port.In alternative embodiment, Equipment can be initially residing in incompletely hydrated state, and allow it to become fully hydrated after the implants, for example, pass through Filled certainly with natural available fluid in eyes.For example, AIOL can include the material in incompletely hydrated state, such as Flow element in AIOL, the material can be fully hydrated by the fluid from eyes, and is pressed down during hydro-combination process System is leaked from AIOL.Such embodiment may rely on the small molecule material included in the permeability and AIOL of water.At this During sample, it is being suitably sized and fill suitable working fluid (typically with it is naturally occurring in eyes The salting liquid of the suitable osmotic pressure of fluid and ionic equilibrium) equipment can be accurate by being subjected to the hypertonic solution of macromolecular Get ready for implantation, such as solution of super high molecular weight glucan.This pretreatment before implantation can inhale fluid from AIOL Go out, so that reducing it delivers cross section.AIOL may then pass through the otch implantation of eyes.After implantation, AIOL can be from eyes Fluid is obtained, so as to update its fluid and optics balance.In some embodiments, AIOL osmotic pressure can be by when making Introduce too big and cannot pass through the molecule for the material diffusion for constituting AIOL further to adjust.In such systems, it can fill out AIOL balance stuffing pressure is adjusted or set when filling.

Figure 10 depicts the AIOL with optional haptic configuration, wherein passing through the sealed bladder 1002 at position 1004 and 1005 Equatorial zone form fluid cavity.Equator chamber 1002 can be connected by the hole 1007 in AIOL structures with rear chamber 1006. The movement of ciliary body can cause the fluid of chamber 1002 to pass in and out chamber 1006, so that single optical element 1003 bends and provides tune Section.

Chamber 1002 and chamber 1006 can be filled, and be filled with other fluids of such as salt solution such as with water or naturally；Sticky is glutinous Knot fluid can be used for preventing the leakage at contact position 1004 and position 1005.

Various methods can be used to improve sealing at position 1004 and position 1005.Glue can be applied as bonding agent To capsule；Fiber mechanism can be induced；Sharp protuberance can be provided at contact point, to increase by making capsule recessed Sealing to capsule；Preceding contact position 1005 can be provided with the instrument at the edge of capture capsulorhexis (capsulorhexis) 1001.

Optical element 1003 can be provided with the instrument being hinged along the edge of optical region to increase flexure and displacement, and And so as to increase focal power.

The component can have the outer mantle for carrying and being closely sized to crystal, and therefore make the possibility of capsule contraction most Smallization.

Due to without conventional haptics, it is understood that there may be less dimensional problem, unique related capsule size is probably it Highly.

The system can be uncorrelated (indifferent) to the permeability change in aqueous humor.

In order to reduce the possibility of leakage, cutting sheet (as cut) size can be in the geometry of regulation.

Figure 11 shows the alternative AIOL according to many embodiments, and it includes two optics members with haptic configuration Part lens combination, haptic configuration is configured to equatorial zone and Background Region formation fluid cavity by sealing lens capsule.It is additional Rear optical element 1101 define fluid optical component or fluid cavity 1102, and can be because optical reasons be (for example, set up Fluid cavity 1102 simultaneously provides improved optics regulation) and be provided.

Figure 12 shows the alternative AIOL according to many embodiments, and it includes two optics members with haptic configuration Part, haptic configuration is configured to equatorial zone and Background Region formation fluid cavity by sealing lens capsule, and wherein film 1201 can be attached to the structure to accommodate fluid.

Figure 13 shows the Alternative AIOL according to many embodiments, and it has haptic configuration, haptic configuration configuration Fluid cavity is formed into by the equatorial zone and Background Region of lens capsule of the sealed bundle containing an optical element, and it is wherein thin Film 1301 can be attached to the structure to accommodate single optical element utensil (optical element implementation) On fluid.

Figure 14 A and Figure 14 B figures show the alternative AIOL according to many embodiments, wherein single optical element lenses Circumference of the supporting construction 1401 along equipment is circumferentially equably opened, and wherein described lens support structure is not attached to fluid The haptics of filling or other conventional haptics.Show to work as in Figure 14 A and Figure 14 B and be placed on lens capsule receiving structure AIOL equipment when in 1405, and lens support structure 1401 contacts at 1402 with rear part lens capsule, and also exist Contacted at 1403 with anterior lenses capsule.The equipment can be positioned so that anterior capsule opening 1404 and lens support structure 1401 It can be alignd in some way with capsulorhexis 1408, to influence the mechanical seal in work, as described below.Figure 14 B are illustrated Postoperative installed AIOL, wherein lens capsule have complied with installed equipment, and there is provided producing chamber 1405 With the sealing needed for chamber 1406, for the activation and releasing of the regulation of lens.AIOL can be inserted it is natural intracapsular and with day Right capsule connects so that the semicircle annulus region of attachment regions sealed bladder.Fluid transfer between semicircle annulus region and AIOL inside The regulation in AIOL can be caused to change.

Figure 15 to Figure 23 B figures show alternative AIOL embodiments, and it focuses on their making.Figure 15 is by preceding The optical sub-assembly that portion's lens element 1501 and posterior lens element 1502 are constituted.Optical fluid passage 1503 allows fluid to enter Fluid optical component or optics cavity 1504, and sub-component is attached to lens support structure 1601 at mounting hole 1505.

Figure 16 A and Figure 16 B depict the optical sub-assembly for the Figure 15 being insert molded in lens support structure 1601, and Contact point 1602 and 1603 is combined together to complete AIOL components wherein at 1604.

The embodiment that Figure 17 shows the modification of Figure 16 the embodiment above, the present embodiment is opaque comprising rear portion Unit dam 1701 and capsulorhexis support lugn 1702.

Figure 18 figures show the final components of AIOL, and wherein optical sub-assembly 1806, which is inserted into, is molded into lens support structure In 1805, wherein haptic configuration 1801 is attached to 1805 at point 1802 and 1803, so as to produce tactile fluid cavity 1804.This is matched somebody with somebody Putting can be alternatively comprising lens as shown in Figure 19, and wherein optical module 1901 is being inserted at post 1902 using solvent or heat It is attached to supporting construction 1903.Figure 19 lens combination is entered by hydrated lens system until it expands about 10% after assembly Row sealing, so as to cause fluid tight press-in cooperation.

Figure 20 is the top view for including the AIOL such as Figure 19 optical modules described.Insertion point and binding site 2001 are shown Go out.When fluid passage 2002 allows fluid to be transferred in fluid optical component or lens cavity 2005, because haptic configuration 2003 By the equator circumference compression of lens capsule (not shown), regulation can occur.Tactile burr (haptic relief) 2004 can be with Minimum circumferential stress is provided during compressing, and can be provided when compression stress relaxation and quickly recover to non-regulated position.

Figure 21 A are the transverse sectional views of the AIOL in Figure 20, indicate the point 2101 of minimal deformation in haptic configuration, and Figure 21 B depict the deformation for the haptic configuration that physiology associated loadings are provided in haptic configuration.Figure 22 is Figure 20, Figure 21 A and figure The axonometric drawing of 21B AIOL components.

Figure 23 A are alternative embodiment and assembly method, and wherein lens combination 2302, which is inserted into, is molded into outside haptic configuration In shell 2303.Figure 23 B show with sealed tactile seam 2307 to produce the complete AIOL components of tactile chamber 2308.

Figure 24 depicts the optional low profile AIOL with alternative haptic configuration and supporting construction, and supporting construction is by such as Optical texture described herein, rear portion haptic configuration 2406 and anterior haptic configuration 2407 are constituted.Optical texture can be via It is installed to post 2402 and aligns and fixed, and post 2402 can be combined at point 2401.Tactile seam 2442 can be tied Close to form sealing and produce tactile fluid storage chamber 2404.In such embodiments, the engagement at point 2401 and haptic interface Seam 2442 can form fluid tight seal to prevent fluid from leaking into tactile fluid storage chamber 2404 and/or from tactile fluid storage chamber Leaked out in 2404.Optical texture 2405 can be including that can be the frontal plane component of deflection and can resist after flexure Portion's plano-convex component.

The embodiments described herein can in many ways in one or more combine.For example, Figure 25 A to 28B It can be combined so as to including similar structures as described herein or alternative construction, Yi Jiqi with Figure 31 to 35B embodiment The last two digits of combination, wherein identifier identify similar structure.

Figure 25 A show the model of the regulation potentiality similar to Figure 24 AIOL.AIOL includes not scratching for far vision Song configuration 2521 and the flexure configuration 2522 near vision.AIOL, which is shown as being in having, is connected to lever haptic configuration In the non-regulated configuration of the planar configuration of 2502 forward plane deflection component 2503.The external structure of haptics 2502 by with Engagement lens capsule is set to, and structure as described herein for reducing the pressure on capsule can be included.Rigid member 2510 can include the lens for providing focal power for far vision.Deflection component 2503 can include the structure of general planar Part, the component of the general planar has for example less constant thickness.Deflection component 2503 includes internal opticses part 2525 and extension 2511.Extension 2511 internally extends between opticator 2525 and the haptic configuration 2502 of rotation.When When internal opticses part 2525 includes convex deflection division 2524, the fluid forming of the chamber of internal opticses beneath portions is offer optics Correction.

Deflection component 2503 and rigid member 2510 define at least a portion of inner chamber 2512.Inner chamber 2512 includes The fluid of the big refractive index of the refractive index of aqueous humor with than eyes.When deflection component 2503 includes the curvature of increase, Internal flow constitutes convex lens shape and provides extra focal power.

AIOL includes the center thickness that the outer surface of deflection component 2503 is extended to from the outer surface of rigid member 2510. Center thickness can be included in the first center thickness 2530 of AIOL lens and the AIOL near vision configuration in far vision configuration Second center thickness 2531 of lens.The increase of the thickness of lens centre is relevant with the focal power of the increase of lens.The increasing of lens Square substantially inverse correlation of big focal power also with the diameter of central optic portion.Extension can reduce the straight of opticator Footpath, and provide the focal power increased for the knots modification between the first distance 2530 and second distance 2531.

Rigid member 2510 is connected to haptic configuration 2502 so that when lens regulation is near vision, haptic configuration 2502 rotations.Haptic configuration 2502 extends to the first anchorage zone of such as anchor point 2540, and haptics surrounds the anchor point phase Rotated for rigid member 2510.Haptic configuration extends from the first anchorage zone to the distance of the wall of lens capsule.Haptic configuration 2502 extend to the second anchorage zone, such as the second anchor point 2541.Second anchorage zone 2541 is connected to deflection component 2503, to cause inward force on deflection component.Tied from first area to the outside of the haptics of engagement lens capsule The distance of structure is more than the distance from first area to second area.Lens capsule power is provided in deflection structure apart from the upper difference Mechanical lever effect on part 2503.The power of the lens capsule acted on deflection component 2502 causes the convex of deflection film Deflection division 2524.Extension 2511 includes opposite concave curvature.

Although extension can include opposite concave curvature, can in many ways in one or more offers The curvature is to reduce visual artifact.The amount for adjusting optical correction can be about 2 to 10 diopters so that extension it is opposite Curvature can not include the appreciable optical effect of patient.In addition, eyes include spherical aberration naturally, and a small amount of aberration can Can be imperceptible.In addition, lens can be sized so that at least the one of the concave portions of pupil covering local inclination Part.In at least some embodiments, the thickness profile of the extension of flexible component can be thinner with by opposite song Rate focuses on the relatively thin exterior section of deflection component.The work related to embodiment shows, for example, general planar Deflection component reduces the visual artifact that may occur with internal reflection, however the deflection component of bending can be provided and It is configured to suppress the visual artifact related to internal reflection.

In many embodiments, haptics 2502 includes the outside storage chamber for being connected to chamber 2512, and for example, works as eyes During regulation, in addition to the inward force of the haptics 2502 at anchor point 2541, the power of haptics to outside storage chamber can be by Fluid pushes chamber 2512 to.

AIOL as described herein can be studied with finite element modeling.Although can in many ways in one kind Or a variety of execution finite element modelings, but in many embodiments, finite element modeling is carried out with known commercial software, example Abaqus as known to persons of ordinary skill in the art.Lens described herein can be with finite element grid and as retouched herein The known materials property for the one or more materials stated is modeled, and determines responses of the AIOL to lens capsule power.

Those of ordinary skill in the art can be exported using the finite element modeling of lens as described herein, and be responded Lens capsule power determines AIOL focal power, such as to determine appropriate AIOL parameters to provide regulation for eyes.At least scheme 25A to Figure 28 B and Figure 31 to Figure 35 B shows the response to the power of pouch according to the AIOL of embodiment.

Figure 25 B show the sectional view for the model that Figure 25 A are developed and come from it.It should be noted that lens or optical texture include The individually exceptional space between lens, and should be noted that rear portion haptic configuration 2506 and anterior haptic configuration 2507 are included in addition Matching surface 2508.In such embodiments, haptic configuration 2506,2507 can be with over-molded (over molded) to thoroughly On mirror or optical texture 2503.Haptic configuration 2506,2507 can be made up of thermoplastic or solvent weldable material, so that Contribute to the connection of two half-unit.Features including matching surface 2508 can also include fluid path 2509 or unshowned Location feature and alignment feature.

In the embodiment of the AIOL according to Figure 25 A- Figure 25 C, the flexure of flexible structure or lens 2503 can be led Will by be applied to haptic configuration 2502 it is peripheral edge, flexible structure is delivered to by the center section of haptic configuration 2502 Or the mechanical forces of lens 2503 drives.Because flexible structure or lens 2503 are not positioned immediately on non-deflected lens 2510, So flexible structure or lens 2503 can be allowed to bend as shown in figure.In such embodiments, deflection lens Or the flexure that structure 2503 undergoes will increase the production between flexible structure or lens 2503 and non-deflected structure or lens 2510 The regulation focal power of raw fluid optical component or lens, and fluid optical component volume will with regulation focal power increase and increase Plus.Therefore other optical fluid may be needed, and is carried via storage chamber of the passage 2509 from included in haptic configuration 2502 For other optical fluid.

Figure 26 represents Figure 25 A- Figure 25 C AIOL modification, and its middle front part haptic configuration 2602 is in haptic configuration wall It is reinforced that preferably power is coupled in flexible structure 2603 at 2606.There is provided from the equatorial zone of the capsule structure of eyes Power is coupled via the periphery of haptic configuration 2602, so as to produce torque around bending point 2611.The torque produces deflection knot The outside flexure of structure 2603.

Figure 27 is analogous to the expression of Figure 24 AIOL regulation potentiality.AIOL includes flexible structure or front lenses 2703rd, the haptic configuration of rigid or not bending component 2710 and support flexible structure 2703 and rigid member 2710 2702.When being placed in eyes, deflection component 2703 can be located on AIOL front part, and rigid member 2710 It can be located on AIOL rear portion.In this embodiment, the haptic wall 2706 of haptic configuration 2702 is connected to and AIOL Inner chamber 2712 fluidic lens structures be in fluid communication (for example, by fluid passage) tactile storage chamber 2707.Can be at least The flexure of optical texture is provided partially by by haptic configuration 2702 and the Fluid pressure of the flexure generation of haptic wall 2706 The flexure of component 2703.For example, the periphery of haptic configuration 2702 can be by being applied to the peripheral power (example of haptic configuration 2702 Such as, the inward force of capsule structure) rotation, and then cause inwardly collapsing for tactile storage chamber 2707, so as to increase tactile storage chamber 2707 Fluid is simultaneously transferred in fluidic lens structures 2712 by interior pressure from tactile storage chamber 2707.The volume of fluidic lens structures 2712 Increase can cause deflection component 2703 to be moved forward relative to rigid member 2710, so as to increase curvature and increase the light of eyes Focal power.In some embodiments, the rotation of haptic configuration 2702 can further result in flexible structure 2703 and rigid member 2710 move together relative to haptic configuration 2702 on direction opposite to the direction of rotation, to increase the focal power of eyes.

Figure 28 A and Figure 28 B figures show Figure 25 and Figure 26 AIOL modification.Figure 28 A show AIOL semi-section. AIOL is made up of optics or lens arrangement 2805, the optics or lens arrangement 2805 so that by flexible structure or component 2803, The lens cavity or fluid optical component 2812 of rigid or not bending lens or component 2810 and fluid filling is constituted.Optics Or lens arrangement 2805 can be kept together by haptic configuration 2802.Haptic configuration 2802 can include alignment structures 2816, can be by AIOL stacked elements in the alignment structures 2816 in period of assembly.Alignment structures 2816 can also include Alignment post 2822 and diaphragm element 2826.Other elements include distance piece 2814 and lid seal 2815.Constitute haptic configuration 2802 material is typically that solvent is welding and/or thermoweldable.Spacer element 2814 includes the lens for promoting fluid filling The passage of fluid communication between chamber 2812 and tactile storage chamber 2813 including barrier film 2826.The He of lens cavity 2812 of fluid filling Tactile storage chamber 2813 can form the closed system for such as sealing storage chamber.In this embodiment, tactile storage chamber 2813 will not example Such as deformed by being applied to the peripheral activating force of haptic configuration 2802.On the contrary, can be isolated in order to avoid undergoing from eyes Cystic structures delivering direct force diaphragm element 2826 for adapt to fluid filling lens cavity or fluid optical component 2812 Interior pressure change and bend.Diaphragm element 2826 can be fluidly coupled to the lens cavity 2812 of fluid filling so that as schemed Volume increase and deflection of the anterior flexure of diaphragm element 2826 shown in 28B corresponding to the lens cavity 2812 of fluid filling The rear portion flexure of structure 2803.It is such when expecting to be used only in the power produced at the equatorial zone of capsule to adjust modulability Embodiment can have the advantage that.In such embodiments, the pressure in interior lens chamber can be negative.

The embodiment above it is many in, such as in the embodiment of Figure 24 to Figure 28 B, at AIOL all parts When drying regime, AIOL will be assembled.When optics or lens arrangement are made up of hydrophily PMMA copolymers, the system will be Assembling is hydrated when completing.When hydrated, hydrophilic len part will expand, so that the sealing of the chamber in enhancing structure.

The embodiment that Figure 29 shows AIOL, wherein lens or optical texture pass through lens 2910 are over-molded to AIOL Two half-unit 2906 and 2907 in each in and produce.As indicated, lens are identicals.However, in some embodiment party In case, such as when a lens are deflections, and another lens is when being not bending, it may be desirable to which lens are different 's.Haptic configuration 2902 including tactile fluid cavity 2913 can be in assembling by the peripheral cell of bending structure 2906 and will It is attached to mating surface 2903 and produced.In this embodiment, seam 2908 can keep uncombined.Implement such In scheme, when pressure is applied to the outer surface of haptic configuration 2902, lens 2910 will be displaced by and bend.Such structure is also Advantage can be provided by minimizing delivering cross section, because when structure is compressed, the first half and lower half can be at those Stretched on this.

Figure 30 figures show the lens arrangement of the AIOL from Figure 29, and it includes hole characteristic 2920, is arrived when lens are over-molded When in any half portion of AIOL structures, hole characteristic 2920 contributes to the fixation of the part of haptic configuration 2902.

The embodiment that Figure 31 shows AIOL3100, the AIOL3100 includes the deflection structure comprising concave regions 3111 The chamber 3112 of part 3103, rigid or not bending component 3110 and fluid filling.In this embodiment, female member 3111 Concave surface the core of concave regions 3111 is inwardly bent relative to rigid or not bending component, to produce deflection structure Part 3103 outwards deflects into convex configuration relative to rigid or not bending component.In many embodiments, when When AIOL3100 is placed in lens capsule, the inside flexure of recess area 3111 is forwardly on direction, and recess component The outside flexure of 3111 core is in backward directions, or in alternative embodiment, vice versa.In many realities Apply in scheme, concave regions 3111 have uniform thickness.

The embodiment that Figure 32 shows AIOL3200, it include the deflection component 3203 comprising concave regions 3211, Rigid or not bending component 3210, the lens cavity 3212 of fluid filling and include the haptic configuration of wall 3221.In the implementation In scheme, the rotation of the concave surface of female member 3211 by haptic configuration and haptic configuration wall 3221 relative to rigid member 3210 turns Change outside flexure of the deflection component 3203 relative to rigid member 3210 into so that when the exterior section direction of deflection component When rigid member is moved, the center of deflection component 3203 is separated with rigid member 3210.In many embodiments, when When AIOL3200 is placed in lens capsule, the inside flexures of concave regions 3211 is forwardly on direction, and spill shape structure The outside flexure of the core of part 3211 is in backward directions, or in alternative embodiment, vice versa.In many In embodiment, concave regions 3211 make the remainder of deflection component 3203 thinning, so as to as hinge.For example, spill Region 3211 can include the concave cutouts of the exterior surface area of deflection component 3203.

Figure 33 is shown in the schematic diagram for not bending the AIOL in configuration 3321 and flexure configuration 3322.AIOL includes rigidity Or not bending component 3310 (for example, optical surface of a more convex bendings), deflection component 3303 are (for example, have Uniform and constant thickness is to suppress the optical material of distortion), fluid-filled chamber 3312 and lever or cantilevered tactile knot Structure 3302.Lever-type structure haptics 3302 is thin near the first anchor point 3340 or such as outward flange of rigid member 3310 Rigid member 3310 is connected at partial region.First anchor point 3312 or region can be along extending through rigid member Any point of the axis of 3310 outward flange and the circumference of lever-type structure haptics 3302 or region.When AIOL is placed on eyes Lens capsule in when, the circumference of lever-type structure haptics 3302 can be in the direction of the optical axis transverse or perpendicular to eyes Upper extension.Lever-type structure haptics 3302 is also connected at the second anchor point 3341 or region by resilience extension 3311 To deflection component 3330.In many embodiments, resilience extension 3311 has the thickness than deflection component 3303 Small thickness.In these embodiments, lever-type structure haptics 3302 has thickness and the length bigger than the thickness.Lever The length of formula structure haptics 3302 can be more than the distance between the first anchor point 3340 and the second anchor point 3341 so that machine Tool leverage (for example, pressure of inward force or eyes from lens capsule) can be from lever-type structure haptics 3302 The ends of lens capsule of contact eyes be applied to the second anchor point 3341.

In many embodiments, lever-type structure haptics 3302 surrounds the first anchor point 3340 of rigid member 3310 Rotation can on resilience extension 3311 applying power, to make resilience extension 3311 and deflection component 3303 exist Opposite direction is bent with opposite curvature.For example, the rotation resilience extension 3311 can be caused mobile closer to The rigid member 3310 of outside concave surface, and make deflection component 3303 further away from the rigidity with convex external surface Component 3310 is separated.The flexure of deflection component 3303 can relate to the transformation from the first diameter D1 to Second bobbin diameter D2, and second is straight Footpath D2 is less than the first diameter D1.The reduction of diameter dimension can cause (such as ball of deflection component 3303 of convex deflection division 3324 Shape deflection division) away from rigid member 3310.In flexure configuration 3322, the convex deflection division 3324 of deflection component 3303 can be with Characterized by curvature, and resilience extension 3311 can be characterized by opposite curvature.The curvature of convex deflection division 3324 Can be opposite with the curvature of resilience extension 3311.For example, the curvature of convex deflection division 3324 can along AIOL appearance Face is just, and the curvature of extension can include the negative cruvature along AIOL outer surface.

Change diametrically of the deflection component 3303 from D1 to D2 can produce corresponding away from rigid member 3310 Amplification motion so that the flexure height between the first height 3330 and the second height 3331 is more than corresponding change diametrically. In such embodiments, the positive camber of spherical deflection division can cause the chamber 3312 of fluid filling that the bending of more convex is presented Profile is to change AIOL focal power.The change in shape of the chamber 3312 of fluid filling can cause the increase in volume, and So as to which fluid is for example incorporated into the chamber 3312 of fluid filling from peripheral storage chamber.Alternatively or in combination, deflection component 3303 and fluid cavity 3312 change in shape can not there is no material change in the volume of chamber 3312 in the case of occur.Example Such as, for example by the exterior section withdrawn fluid from chamber 3312 without from peripheral storage chamber withdrawn fluid, the chamber 3312 of fluid filling Change in shape the reallocation of internal flow can be caused to change focal power.In addition, when AIOL is placed on lens capsule When middle, the rotation of lever-type structure haptics 3302 can cause deflection component 3303 and rigid member 3310 in forward direction On translated together relative to the outward flange of lever-type structure haptics 3302.This translation can further change the light focus of eyes Degree.Separation of the deflection component 3303 away from rigid member 3310, deflection component 3303 bend to increase its curvature, Yi Jike The translation of deflection component 3303 and rigid member 3310 together in forward direction can combine to change the focal power of eyes.Example Such as, the small contraction for the lens capsule that this combination can will accommodate AIOL is enlarged into significantly changing in AIOL focal power.Light This change in focal power can be significantly greater than separation, flexure and any one only in translational motion.

Haptic configuration described herein can comprising siloxanes, polyurethane or other suitable thermoplastics, PMMA and PMMA copolymers.In many embodiments, haptic configuration includes and the same or analogous material of optical texture.

Figure 34 A show the AIOL according to embodiment.As noted herein, the configuration 3421 not bent is shown with grey Go out, and bend configuration 3522 and shown with oblique line.AIOL includes internal opticses part 3525 as described herein and extension. The similar structure identified with similar rear two digits is identified herein.

Figure 34 B show the internal pressure of the AIOL chambers as shown in Figure 34 B.The pressure of inner chamber 3412 be shown as with Load and increase.It is this with the increased pressure of load show lever haptic configuration inward force and AIOL internal pressure all Contribute to the convex deflection division 3424 of internal opticses structure 3425.

Figure 35 A show the AIOL according to embodiment.As noted herein, the configuration 3521 not bent is shown with grey Go out, and bend configuration 3522 and shown with oblique line.AIOL includes internal opticses part 3525 as described herein and extension. The similar structure identified with similar rear two digits is identified herein.

Figure 35 B show the internal pressure of the AIOL chambers as shown in Figure 35 B.The pressure of inner chamber 3512 be shown as with Load and reduce.This pressure reduced with load shows that the inward force of lever haptic configuration can provide internal opticses The convex deflection division 3524 of structure 3525.Further, since pressure is negative value, the pressure response curve is shown, with the stream from chamber The pressure of body is on the contrary, the change in flexure and focal power is the result of the inside radial load of Mechanical Driven.Figure 35 B are shown The inward force of lever haptic configuration can bend deflection component 2502 with the negative pressure of inner chamber.

With reference to

With reference to can be used for combining one or more of many AIOL structures as disclosed herein.Structure can be with such as One or more combinations in many modes described herein, and step, process and material can be combined to provide AIOL The improved combination of structure.

For example, the combination of part can be used for one or more of many IOL parts, Ke Yiyong as described herein One or more in many IOL materials, can be used for modulability and non-regulated IOL, and can be used for such as this paper institutes One or more of many AIOL of description.Modulability IOL can include one or more haptics, and disc-shaped part is joined Pouch is connected to, power of lens is changed so as to the deformation in response to pouch.In many embodiments, it is one or more to touch Feel portion includes chamber, and the chamber is fluidly coupled to include the chamber of the first lenticular unit and the second lenticular unit.Haptics can be by herein Described soft material is made, such as acrylate polymer or siloxane polymer and combinations thereof.

While reference has been made to the polymer of rigid machining is combined, but combines can be used for hydration as disclosed herein Polymer, soft hydrated polymer, machining polymers, molded polymeric thing, molding dry polymer, molded-rigid-polymer, Mould the one or more in the hydrated polymer and combinations thereof of flexible polymer or molding.

In many embodiments, AIOL includes first component and second component.First component includes the first disk-shaped structure, And second component includes the second disk-shaped structure.Loop configuration extends with boundary between the first disk-shaped structure and the second disk-shaped structure Constant volume receive with greater than about 1.336 refractive index fluid chamber, 1.336 be the refractive index of the aqueous humor of eyes.When the first disk During the curvature increase of one or more of shape structure or the second disk-shaped structure, AIOL focal power increase.

First component and second component can be bonded to each other at one or more mating surfaces.Mating surface can be selected Position to reduce influence of the mating surface to AIOL optical property.For example, mating surface can surround loop configuration, the first disk One or more of shape part, second disc-shaped part and combinations thereof are extended circumferentially over upon.In many embodiments, mating surface It is located around connecing for one or more of loop configuration, the first disc-shaped part, second disc-shaped part and combinations thereof circumferentially extending In seam or near, part is combined together by seam.Seam is located remotely to the opticator of first component and second component There is provided improved optical property.

In many embodiments, first component and second component are machined rotationally symmetrical to provide on lathe Structure, such as the first disk-shaped structure and the second disk-shaped structure.Before part is combined together, first component or second One or more of part can include loop configuration.One or more annulars can be set on first component and second component Groove, to make first component optically be alignd with second component.Annular groove or a groove or multiple recessed for other shapings One or more parts of groove can be used as the mating surface for first component and second component to be combined together.

It can use various technologies that first component and second component are bonded to each other.It is, for example, possible to use directly in conjunction with side Method is coupled mating surface described herein.Direct bonding method, which can be advantageously provided, continuously combines linking part, the knot Linking part is closed with the similar material and mechanical performance to the remainder of structure.For example, can be similar to reference to linking part The first component and second component of structure and expand.Exemplary direct bonding method can include thermal, solvent combination, office Portion is welded or surface is modified.

The thermal of first component and second component can be related to part (for example, at or near mating surface) heating To the temperature of the glass transition temperature for the one or both being close to or higher than in part.During heating process, it can apply Pressure is to increase contact force of the part between mating surface.It can cause part using appropriate temperature and pressure condition Polymer chain phase counterdiffusion and entangled with one another between mating surface, so that first component and second component are combined one Rise.

Solvent combination, which can be related to the mating surface of first component and second component, applies suitable solvent.Solvent can be with Make the polymer chain solvate of part at mating surface, so that the chain-mobility between increasing mating surface and mutually expansion Dissipate.For example, handling mating surface by using suitable solvent can promote by the molten of the part of HEMA and MMA copolymer manufacture Agent is combined.Exemplary solvent can include EGDMA, diethylene glycol dimethacrylate (DEGDMA), triethylene glycol dimethyl allene Acid esters (TEGDMA), water, methanol, ethanol, acetone, dimethyl sulfoxide (DMSO), acetonitrile, isopropanol, n-hexyl alcohol, dichloroethylene, dichloromethane Alkane, hexamethylene or their suitable combination.Mating surface can be cleaned, and then use wet with solvent.Mating surface can be with It is in contact with each other and by being subjected to suitable pressure and temperature condition (such as using forcing press, baking oven, heating plate) up to pre- fixed length The time of degree combines.

Local welding, which can be related at or near composition surface, applies energy with focusing on, and table is combined to heat and soften Face, so that part be combined together.The energy of appropriate format can include ultrasonic energy, microwave energy or infrared energy. Under certain situation, suitable part can be formed in one or more parts, table is combined so as to which the energy of application is directed to The appropriate area in face.

As another example, suitable process for modifying surface can apply in mating surface described herein one It is individual or multiple, so as to realize directly in conjunction with.Surface, which is modified, can relate to processing mating surface to increase its surface energy, so as to improve table Face contacts and increases the degree of the polymer chains entanglement between mating surface.In many embodiments, plasma can be passed through Body activation, UV exposures and/or ozone exposure are modified mating surface.The ginseng of surface modification treatment described herein can be selected Number (such as processing time), to optimize the degree of surface rearrangement of the polymer chain at mating surface.

Alternatively or additionally, it can use using the indirect combination technology of proper adhesive come the first component with reference to AIOL And second component.Adhesive can be applied at least a portion of mating surface described herein.In many embodiments, Adhesive of the selection with the material and mechanical performance similar with second component to first component.For example, adhesive can be included The prepolymer of the polymer of part.Prepolymer can include the monomer of such as polymer, oligomer, partially cured monomer, One or more in grain or nano particle.The embodiment of such combination can provide advantage, because no seam or depositing In the seam of reduction, there is the mechanical property similar with structure with reference to linking part.For example, adhesive can be similar to first component Expanded with second component.For example, when adhesive is circumferentially set around first component and second component as described above, this can To be helpful, because these parts generally diametrically can expand with circumference.Subtract along AIOL mating surface Small stress is helpful, because AIOL can be made smaller to reduce insertion size, and can include being configured to subtracting Small stress and the thin deformable structure deformed.

In many embodiments, adhesive (for example, prepolymer) solidifies to combine first component and second component Together.Solidification process can be directed to use with one or more components of technology polymeric binder well known by persons skilled in the art. For example, the precursor monomer in prepolymer can partially or completely be polymerize by adding initiator.Initiator may, for example, be light Initiator, such as Irgacure 651 (I651, Ciba-Geigy), or radical initiator, such as 2,2'- azos double (isobutyronitriles), 2,2'- azos double (2,4- methyl pentane nitriles), dilauroyl peroxide or two (4- tert-butylcyclohexyls) peroxy dicarbonates. In many embodiments, monomer polymerize in the presence of crosslinking agent.Crosslinking agent can comprising EGDMA, DEGDMA or One or more in TEGDMA.The polymerization of monomer and crosslinking agent can form interpenetrating polymer networks (IPN), IPN polymerization Thing network can tangle with first component and second component, so that they be bound up.In some cases, it can use Suitable activator, to provide exposed reactive group, is enable in mating surface and pre-polymerization to activate mating surface Chemical bond is formed between thing and/or crosslinking agent., can be by rinsing, immersing suitable solvent or ability after polymerization process Other methods known to the those of ordinary skill of domain remove excessive reagent.

Combination technology described herein can be during AIOL described herein manufacture any point application.For example, First component and second component can be bonded to each other when in the rigid configuration generally dried.Each in part It can be provided with rigid arrangement, for being machined and being combined with adhesive one when in rigid arrangement Rise.Part can be then hydrated.Alternatively, part can be combined when in partly or completely full hydrated configuration.

In many embodiments, the first lenticular unit and the second lenticular unit include hydroxyethyl methacrylate and methyl The copolymer of methyl acrylate.When solidified, adhesive includes the copolymerization of hydroxyethyl methacrylate and methyl methacrylate Thing.It is fully hydrated that this configuration can allow adjoint significant expansion lens to be expanded to from rigid incompletely hydrated configuration Configuration, and suppress the stress of adhesive positioned to part and along seam.It will be recognized by one of ordinary skill in the art that polymerization The rigid incompletely hydrated configuration of thing material includes the polymer with water a small amount of enough, thinks first component and second The polymeric material of part provides rigidity.Incompletely hydrated configuration can include water (such as 0.2%- by being no more than about 5% 3% water) composition generally dry configuration so that polymeric material includes enough rigidity, for making material mechanical It is processed into accordance with optical tolerance, this will readily appreciate that to one of ordinary skill in the art.For example, when AIOL be placed on it is crystalline In somatocyst or when being placed in the hydration buffer solution that those of ordinary skill in the art are understood, polymer may be expanded to hydration shape State is simultaneously inflated gradually to fully hydrated state.Polymer in fully hydrated state can be by e.g., from about 15% to 30% Water is constituted, and this depends on selected material.Polymer in fully hydrated state can expand more than 10%, for example 10% to 15%.

Figure 36 shows the method 3600 for making and providing AIOL.

There is provided polymeric material block as described herein at step 3610.Material block is cut into first component 3612 and second component 3614.Polymeric material includes rigid arrangement as described herein.

At step 3620, first component 3612 and second component 3614 are shaped as AIOL the first lenticular unit 3622 With the second lenticular unit 3624.These parts can in many ways in one or more shape, for example got on the bus in lathe Cut, cut, the other known method of ablation and shaped optical lens.Alternatively or in combination, part can be molded.Portion Part 3622, one or more of 3624 includes being configured to the features 3626 for receiving opposed parts (for example, features 3626 can With including annular groove).Passage 3628 can be provided to allow the fluid communication with AIOL chamber 3636.Alternatively or combination Ground, when first component and second component are combined together, passage 3628 can be formed.

At step 3630, first component 3622 and second component 3624 and the adhesive being arranged in features 3626 3632 are combined together.First component 3622 and second component 3624 define chamber 3636.

The prepolymer of polymer of the adhesive 3632 comprising part 3612 and 3614.Although component is shown as by single piece There is provided, but polymeric material can be provided with the material block of the separation with similar polymer component.

Haptics 3638 can be fixed to AIOL3635 so that IOL inner chamber is fluidly coupled to the chamber of haptics.Touch Feel portion can include the material or different materials similar to AIOL.

Haptics 3638 can have thickness 3639.For example, AIOL can include acrylate as described herein, and And haptics 3638 can include soft silicon materials.For example, when AIOL includes rigid arrangement, haptics can include being inserted into Soft material in AIOL.

AIOL in rigid arrangement is included across size 3634, such as diameter.AIOL can be included in AIOL bodies Foremost portion and AIOL bodies decline between the thickness 3648 that extends.

At step 3640, AIOL3635 is hydrated to the configuration that is generally hydrated to reduce rigidity so that AIOL includes Soft material.In hydration configuration, AIOL size increase, and mutually can proportionally increase.In many embodiments, The increase includes the percent similarity increase along each dimension.

In many embodiments, the hydration of the hydration level in rigid arrangement including scheduled volume is so as to by lenticular unit Accurately it is machined into the appropriate refracting power when AIOL includes fully hydrated state when AIOL is being implanted into eyes.

The disk shaped optical structure of upper member 3622 can be for example flat or lens shape.Lower member 3622 Disk shaped optical structure can be flat or lens shape, for example, cause the deformation of one or more of optical texture to provide Focal power.

Figure 37 shows the optical texture of deformation, and the optical texture has the surface profile of flexure so as to as retouched herein The spherical surface profile 3700 for the bending stated provides focal power.AIOL fluid can be more than 1.33 refractive index of aqueous humor, To provide the focal power of increase with curved surface 3700.Optical component 3624, which can be included in the first configuration, not to be provided significantly Focal power general planar shape, and can be deformed to provide for adjust focal power bending spherical surface Profile 3700.

Although with reference to acrylate, polymer and prepolymer can include such as silicone hydrogel material.

Figure 38 A show AIOL, and wherein (the two is in the page before the foremost portion of haptics for AIOL foremost portion Bottom is shown), wherein AIOL deflection component is configured to the translational and rotational movement flexure of haptics.Alternative real Apply in scheme, as described herein, lens can be placed with opposite previous dynasty direction.As described herein, deflection structure Part 3803 includes enough radial strengths so that the radially inner power to the exterior section of deflection component causes deflection structure The flexure of the interior section of part.

Deflection component can in many ways in one or more configurations to provide radial strength, it is at least interior to make Portion part is for example bent with regard to one or more of modulus of elasticity, thickness or diameter.

AIOL includes not bending configuration 3821 and for near-sighted flexure configuration 3822 for far vision.AIOL is depicted It is connected to in non-regulated configuration, non-regulated configuration has before the planar configuration of lever haptic configuration 3802 Facial planes deflection component 3803.The external structure of haptics 3802 is configured to engage lens capsule, and can include such as The structure described herein for being used to reduce the pressure on capsule.Rigid member 3810 can include being used to provide focal power for far vision Lens.Deflection component 3803 can include the component of general planar, and the component of the general planar has for example substantially Upper constant thickness.Deflection component 3803 includes internal opticses part 3825 and extension 3811.Extension 3811 is internally Extend between opticator 3825 and the haptic configuration 3802 for translating and rotating.When interior opticator 3825 includes convex deflection division When 3824, internally the fluid of the chamber below opticator is shaped as provides optical correction near vision.

As described herein, deflection component 3803 and rigid member 3810 define at least one of inner chamber 3812 Point.

AIOL includes the center thickness that the outer surface of deflection component 3803 is extended to from the outer surface of rigid member 3810. The center thickness can include the first center thickness 3830 of lens in far vision configuration, and can be near vision is configured The second center thickness 3831 including lens.The increase of the thickness of lens centre is relevant with the focal power of the increase of lens.Lens Increase focal power square substantially inverse correlation also with the diameter of central optic portion.Extension can reduce opticator Diameter, and between the first distance 3830 and second distance 3831 knots modification provide increase focal power.

Rigid member 3810 is connected to haptic configuration 3802 so that when lens regulation is near vision, haptic configuration 3802 rotations.Haptic configuration 3802 extends to the first anchorage zone, such as anchor point 3840, around the haptics of anchor point 3840 Translate and rotate relative to rigid member 3810.Haptic configuration extends from the first anchorage zone to the distance of the wall of lens capsule. Haptic configuration 3802 extends to the second anchorage zone, such as the second anchor point 3841.Second anchorage zone 3841 is connected to flexible Bent component 3803, to cause inward force on deflection component.From first area to the haptics of engagement lens capsule The distance of external structure is more than the distance from first area to second area., should apart from upper at least some embodiments Difference can provide at least some mechanical levers effect of the lens capsule power on deflection component 3803.Act on deflection structure The radial load of lens capsule on part 3802 causes the convex deflection division 3824 of deflection film.Extension 3811 includes conversely recessed Curvature.

AIOL part, such as rigid member, deflection component and one or more haptics can include and this paper institutes The identical polymer of description.For example, these parts can have the pliability and rigidity of the variable quantity depending on thickness.Permitted In many embodiments, haptics includes a thickness, works as it and rotation is utilized in response to the radially inwardly power from lens capsule Or one or more of translation is radially-inwardly promoted during deflection component, at least partly reversibly deform.

Figure 38 B show the inside cavity pressure of the load in response to the AIOL in such as Figure 38 A.AIOL internal pressure with AIOL load approximately linearly increases.

The combination of internal pressure and radially inner power can bend component 3803, to be provided when eyes are adjusted Focal power, it is as described herein.Relative to it is corresponding with the power that lens capsule is acted on AIOL it is one or more it is disclosed most Big load value, the load modeled is normalized, and it is easily true that this can be based on disclosed data by those of ordinary skill in the art It is fixed.Material character such as this paper AIOL modeled can be easily true based on the public data for material as described herein It is fixed.

Figure 39 A show modulability intraocular lens 3900.Intraocular lens 3900 can include center lens region 3904 and the peripheral corrugated part region 3903 with two corrugated parts 3903a, 3903b.Intraocular lens 3900 can be fabricated to Two parts：Top half 3900a and bottom half portion 3900b.Used material can be submissive, such as hydrophily propylene Acid or hydrogel.Other materials can be used alternatively or in combination.Two half-unit 3900a, 3900b can be by joint Top half 3900a is adhered to bottom half portion 3900b to assemble at 3901, as shown in Figure 39 B.Two half-unit 3900a, Cavity 3905 between 3900b can fill high-index fluid, so as to cause intraocular lens 3900 to be used as lens.

The function of dual damascene tubulose features 3903 can increase the response of intraocular lens 3900.Corrugated part 3903 Outermost side 3903c can interact with the pouch of eyes.When bag applies pressure to corrugated part 3903, fluid can be from Corrugated part region 3903 is displaced in center lens cavity.Increased pressure can cause top lens component 3900a to become upwards Shape, so as to change its radius of curvature and therefore produce focal power change and adjust.The corrugated part 3903a of most inner side can be adjusted making Obtaining its outermost wall can be very submissive.Any pressure applied from outermost corrugated part 3903b most inwall can be in fluid Displacement, which goes out in the most corrugated part 3903a cavitys of inner side, to be converted.By this way, if due to along outermost corrugated part 3903 glue-lines and there is the increase in rigidity, then deformation can still be allowed to most inner side corrugated part 3903a in occur.

Can be on bottom half portion 3900b inner surface 3906b, or alternatively, in top half 3900a inner surface The discrete protuberance of a line or projection 3902 are set up on 3906a, as shown in Figure 39 B.Projection 3902 can be used for keeping two and half Gap between portion, so as to contribute to manufacture.

Any one in the features of intraocular lens 3900 can be with other intraocular lenses described herein spy Any one combination in portion is levied, and vice versa.

Figure 40 A and Figure 40 B show modulability intraocular lens 4000.Intraocular lens 4000 can include center lens Region 4004 and peripheral corrugated part region 4003.Intraocular lens 4000 can be fabricated to two parts：Top half point 4000a With bottom half part 4000b.Used material can be submissive, such as hydrophilic acrylic or hydrogel.Other materials It can use alternatively or in combination.Two half-unit 4000a, 4000b can by joint 4001 by top half 4000a It is adhered to base section 4000b to assemble, as shown in Figure 40 B.Cavity 4005 between two half-unit 4000a, 4000b can be with High-index fluid is filled, so as to cause intraocular lens 4000 to be used as lens.

The paddle (paddle) 4002 of series of discrete can be built along the outermost wall of corrugated part 4003.When bag is to oar When shape portion 4002 applies pressure, paddle 4002 can transfer force to the outermost wall of corrugated part 4003, cause the wall radially to Interior deformation.By this way, fluid can be displaced in center lens cavity 4005 from corrugated part region 4003.As in Figure 40 A Shown, periphery of the paddle 4002 along intraocular lens 4000 can not be continuously, to reduce component or lens 4000 circumferential rigidity and therefore reduce radial rigidity.

The fluid of displacement can cause the increase on pressure, and the pressure increase can cause top lens component 4000a is upwardly-deformed, so as to change its radius of curvature and therefore produce focal power change and adjust.Similar to intraocular lens 3900, can be on bottom half portion 4000b inner surface 4006b, or alternatively in top half as shown in Figure 39 B Discrete protuberance or projection is built on 4000a inner surface 4006a.Projection can be used for keeping two half-unit 4000a, 4000b Between spacing so that contribute to manufacture.

Any one in the features of intraocular lens 4000 can be with other intraocular lenses described herein spy Any one combination in portion is levied, and vice versa.

Figure 41 A show modulability intraocular lens 4100.Optical axis 4140 extends through center lens region 4104.Manually Crystalline lens 4100 can include such as center lens region 4104 and the peripheral corrugated part region with such as two corrugated parts 4103.The rigid attachment structure of annular can circumferentially extend around the center lens region 4104 for including optical axis.Annular rigid attachment Structure can include the first annular rigid attachment structure 4107a and the second ring on second component being located on first component Shape rigid attachment structure 4107b.

Two corrugated parts can include the inside continuous wave pattern portion 4103a being in fluid communication with each other and outside continuous wave pattern portion 4103b.In many embodiments, corrugated part includes one or more folding parts.The folding part of corrugated part have when pouch to The resistance to pouch, and the advantage that permission corrugated part is moved radially outward when pouch extends are reduced during interior promotion.Folding part Very gentle outside power against pouch can also be provided and coupled with improving with pouch.Those of ordinary skill in the art can The size in corrugated part region is set according to pouch with the bio-measurement method using such as optical coherence tomography.Corrugated part area Domain 4103 can include the second folding part 4108b on the first folding part 4108a and second component on first component.First folding Folded portion 4108a and the second folding part 4108b inwardly and can be extended towards one another on the direction similar to optical axis.First folds Portion and the second folding part continuously and can be extended circumferentially over upon around optical axis, for example, extend 360 degree around optical axis.Folding part this The flexure offer lens of folding part and coupling for lens capsule can be passed through by planting arrangement.

Corrugated part region can in many ways configure and allow outside storage chamber to join including one or more folding parts It is connected to inner chamber.Though it is shown that the corrugated part of two circumferentially extendings with the folding part extended therebetween, but for example may be used To provide the corrugated part of varying number, such as three or more corrugated parts.Corrugated part 4103a, 4103b are along center lens area The periphery in domain 4104 can be continuous.Corrugated part 4103a, 4103b can be annular, oval or rotationally symmetrical shapes. Fluid may reside in corrugated part 4103a, 4103b continuous internal capacity.Inner corrugations 4103a can be with center lens Region 4104 is in fluid communication.

Rigid attachment structure can be configured with when lens capsule is against corrugated part area away and by fluid in many ways Moved or from corrugated part region to center from when corrugated part zone-transfer is into center lens region 4104, suppressing radially inner The power of lens area 4104.When corrugated part region response is moved radially outward in the power of the reduction of lens capsule, rigidity connection The radial outward movement in center lens region 4014 is similarly suppressed in binding structure.First annular rigid attachment structure can include big In the first radial thickness of the first thickness in the first corrugated part region, and the second loop configuration can be including being more than the second ripple Second radial thickness of the second thickness in portion region.Although the other structures with lens, such as folding part are compared, rigid attachment knot The possible relative stiffness of structure, but rigid attachment structure can be configured to one or more of rolling volume, folding or compression, for Inserted through the small otch in eyes, for example.Intraocular lens 4100 can make in many ways, for example with lathe turning with Shape one or more parts, mould to form one or more parts or directly manufacture to be formed in one or more parts It is one or more.Alternatively or in combination, part with direct manufacture can be made based on the computer model of lens.Lens section Part can be with directly manufacturing separately fabricated or manufacture together.Lens, which can be directly fabricated to, includes the monolithic of part described herein Lens.

In many embodiments, intraocular lens is fabricated to two parts：Top component 4100a and bottom part 4100b.Used material can be submissive, such as hydrophilic acrylic or hydrogel.Other materials can alternatively or Use in combination.Two parts 4100a, 4100b can be attached to base portion by by top component 4100a at joint 4101 Part 4100b is assembled, as shown in fig. 41 a.Cavity 4105 between two parts 4100a, 4100b can fill high index of refraction Fluid, so as to provide deformable fluid space in the intraocular lens 4100 as the lens with variable optical strength.

Peripheral corrugated part region 4103 can include by top component 4100a and bottom part 4100b multiple folding parts The continuous fluid storage chamber or chamber defined, wherein folding part define inner corrugations 4103a and outer corrugations portion 4103b.Top Part 4100a and bottom part 4100b can internally between corrugated part 4103a and outer corrugations portion 4103b to interior folding, with Internally submissive region is defined between corrugated part 4103a and outer corrugations portion 4103b.The submissive region can internally corrugated part One or more fluid passages are defined between 4103a and outer corrugations portion 4103b.Fluid passage can be and inside in shape Closely similar annular, the periphery shapes or rotationally symmetrical of corrugated part 4103a and outer corrugations portion 4103b.In fore-and-aft direction On, the submissive region can be thinner than inner corrugations 4103a and outer corrugations portion 4103b.

Top component 4100a can include the plane institution movement 4110 (Figure 41 C) of deflection, and bottom part 4100a can With including the plano-convex component 4120 that can provide focal power (Figure 41 B).Alternatively, bottom part 4100a can include substantial The flat components of focal power are not provided；And top component 4100b can be prebuckling (or being the form of shell), think cavity 4105 provide shape, and cavity 4105 can fill Refractive fluid to provide focal power.When being placed in lens capsule, top Part 4100a may be at forward position, and bottom part 4100b may be at rear positions.Alternatively, top component 4100a may be at rear positions, and bottom part 4100b may be at forward position.

The function of double fold in multiple corrugations portion features 4103 can increase the machinery of intraocular lens 4100 Response.The outermost side 4103c of corrugated part 4103 can interact with the pouch of eyes.When bag is applied on corrugated part 4103 During plus-pressure, fluid can be displaced in center lens cavity 4105 from corrugated part region 4103.In center lens cavity 4105 The pressure of increase and the volume of fluid will generally cause top lens component 4100a upwardly-deformed and change its radius of curvature, And therefore produce focal power change and adjust.For example, plane institution movement 4110 with upward and can undergo subtracting in radius of curvature It is small.Alternatively or in combination, the spacing distance between two parts 4100a, 4100b increases in response to the pressure of increase, with Changing focal power, (that is, the peripheral region for defining center lens region 4104 of part 4100a, 4100b can be in fore-and-aft direction Upper separation).The corrugated part 4103a of most inner side can be adapted so that its outermost wall can be very submissive.From outermost ripple Pressure that portion 4103b most inwall applies, being caused by the power for the outermost folding part being applied in corrugated part can be in stream Position is removed to be converted in the most corrugated part 4103a cavitys of inner side.By this way, if due to along outermost corrugated part 4103 joint line and there is the increase in rigidity, then deformation still allows for occurring in most inner side corrugated part 4103a.

Corrugated part region 4103 can be around lens area optical axis it is rotationally symmetrical, in order to make.Corrugated part Rotational symmetry structure can the easily turning on lathe, or by can the moulded parts of easily lathe process formed.

For example, multiple protruding portion or projection or post 4102 can be disposed radially within bottom part 4100b inner surface On 4106b, as shown in Figure 41 A, 41B, or alternatively it is disposed radially within top component 4100a inner surface 4106a, And combinations thereof.Projection or post 4102 can be used for keeping the spacing between two parts, so as to contribute to manufacture.At some In embodiment, after top component 4100a and bottom part 4100b put together, projection or post 4102 can be incorporated into Another part of intraocular lens 4100.Space between adjacent projection or post 4102 may be used as corrugated part 4103 and sky The pipeline of fluid between chamber 4105.In some embodiments, projection or post 4102 can be another with intraocular lens 4100 One part is unrelated, so that the asymmetrical deformation of relative flat components is minimized.In some embodiments, with projection or post 4102 relative plane institution movements can include the outer annular regions that are contacted with projection or post 4102 and from outer annular regions and The inner circular shaped region for the deflection that projection or post 4102 are raised and separated.

Top section 4100a and base section 4100b including top component and bottom part can shapes in many ways Into.For example, top section 4100a and base section 4100b for example, by each part of turning on lathe or can pass through mould Make to be formed.In many embodiments, top section 4 and base section each include rotationally symmetrical structure, such as ripple Portion and other parts as described herein.Protuberance can be formed in many ways.Rotationally symmetrical part can be combined one Rise to form lens as disclosed herein.

Corrugated part 4103a, 4103b as disclosed herein can provide the improved of the lens capsule of fluid storage chamber and eyes Connection.Corrugated part 4103a, 4103b foldable structure can provide resilience spring function for storage chamber so that storage chamber can be against Lens capsule is promoted and allows lens capsule to move inward gentlely, and fluid is transferred into interior lens structure from storage chamber, with Focal power is provided.

Protuberance 4102 can form to provide front lenses part 4100a and posterior lens part in many ways 4100b fluid transfer and separation.For example, protuberance 4102 can provide discrete protuberance, projection or post.Alternatively, dash forward The part of such as loop configuration in wheel rim shape portion can be included by going out portion 4102.Wheel rim shape portion can have passage, passage at least portion Divide in ground incision wheel rim shape portion, to allow fluid to shift.Multiple protruding portion can separate to define by multiple protruding portion each other The multiple passages 4107 defined, so as to which chamber is fluidly coupled into storage chamber.

Protuberance 4102 may be located remotely from the part optically used of lens 4100, to suppress optical aberration and artifact.

Any one in the features of intraocular lens 4100 can be with other intraocular lenses described herein spy Any one combination in portion is levied, and vice versa.

Figure 42 shows the cross-sectional view of modulability intraocular lens 4200.Modulability intraocular lens, which include being similar to, to be adjusted The structure of section property intraocular lens 4100, the similar structure of last two bit identification of wherein reference.Modulability intraocular implants Body 4200 is arranged so that chamber 4205 is extended in second component.Compared with lens 4100, second component can include decrement Polymeric material, this can aid in folding, rolling volume or compression lens 4200, to configure with the saturating of narrow insertion profile Mirror, to be placed in the narrow incisions of eyes.

Any one in the features of intraocular lens 4200 can be with other intraocular lenses described herein spy Any one combination in portion is levied, and vice versa.

Although the preferred embodiment of the disclosure has been shown and described herein, for people in the art Member is it is evident that these embodiments are only provided in an illustrative manner.Without departing from the present invention, people in the art Member is it will be appreciated that many modifications, change and replacement.It should be appreciated that can be using described herein public affairs when implementing the disclosure The various alternatives for the embodiment opened.It is intended that following claims and limits the scope of invention, and thus covers at this Method and structure in the range of a little claims and its equivalent.

Claims

1. a kind of modulability intraocular lens, for being placed in the lens capsule of subject, the modulability intraocular lens Including：

First component, it has the first lens area and the first corrugated part region；

Second component, it has the second lens area and the second corrugated part region, and the second component is connected to described first Part；

Fluid cavity, it is between first lens area and second lens area；With

Fluid storage chamber, it is between the first corrugated part region and the second corrugated part region, the fluid storage chamber and institute Fluid cavity fluid communication is stated, is turned with the alteration of form in response to lens capsule between the fluid cavity and the fluid storage chamber Advection body, is changed with providing focal power for the modulability intraocular lens.

2. modulability intraocular lens according to claim 1, wherein first lenticular unit is bonded in joint To second lenticular unit.

3. modulability intraocular lens according to claim 1, are additionally included in the first component or second lens Protuberance on the inner surface of one or more of part, between being provided between the first component and the second component Gap.

4. modulability intraocular lens according to claim 1, wherein first lenticular unit is around described first The joint of lenticular unit and second lenticular unit circumferentially extending is adhered to second lenticular unit.

5. modulability intraocular lens according to claim 1, wherein the first wave line portion region surrounds described first Lens area circumferentially continuously extends, and the second corrugated part region is circumferentially continuously prolonged around second lens area Stretch.

6. modulability intraocular lens according to claim 1, wherein the first wave line portion region is included around described One or more folding parts that the optical axis of first lens area circumferentially continuously extends, and the second corrugated part region includes The one or more folding parts circumferentially continuously extended around the optical axis of second lens area.

7. modulability intraocular lens according to claim 1, wherein the first wave line portion region include inwardly and The first one or more folding parts circumferentially continuously extended around first lens area, and second corrugated part Region includes inwardly and surrounds second one or more folding parts that second lens area circumferentially continuously extends, described First one or more folding parts and second one or more folding parts are extended towards one another.

8. modulability intraocular lens according to claim 1, wherein the first component includes first annular rigidity connection Binding structure, the first annular rigid attachment structure is circumferential between first lens area and the first corrugated part region Extension, with suppress first lens area with the first corrugated part region move radially move radially, and Wherein described second component includes the second annular rigid attachment structure, and the described second annular rigid attachment structure is saturating described second Between mirror region and the second corrugated part region circumferentially extend, with suppress second lens area with second ripple Line portion region move radially move radially, and wherein described first annular structure include be more than the first corrugated part area First radial thickness of the first thickness in domain, and wherein described second loop configuration is including being more than the second corrugated part region Second thickness the second radial thickness.

9. modulability intraocular lens according to claim 1, wherein first lens area includes front lenses portion Part, and second lens area includes posterior lens part.

10. modulability intraocular lens according to claim 1, wherein first lens area includes the first plane structure Part, and second lens area includes the second plane institution movement.

11. modulability intraocular lens according to claim 1, wherein in the first component or the second component It is one or more including shell.

12. modulability intraocular lens according to claim 1, wherein in the first component or the second component One include in flat components, and the first component or the second component another include being shaped to provide focal power Plano-convex component.

13. modulability intraocular lens according to claim 1, wherein the fluid in the fluid cavity makes the fluid cavity It is configured to focal power.

14. modulability intraocular lens according to claim 13, wherein the focal power of the modulability intraocular lens Change include the change for the focal power that flow profile in the fluid cavity is provided.

15. modulability intraocular lens according to claim 14, wherein the shape of the fluid in the fluid cavity The change for the focal power that shape is provided includes the change of the shape of the fluid cavity.

16. modulability intraocular lens according to claim 1, wherein the focal power of the modulability intraocular lens Changing includes the change of the spacing distance between first lens area and second lens area.

17. modulability intraocular lens according to claim 1, wherein positioned at the corrugated part region and the lens region First lenticular unit is connected to second lenticular unit by protuberance between domain, and wherein described protruding parts in In one or more rigid attachment structures of one or more of first lenticular unit or second lenticular unit, with Gap is provided between the first component and the second component.

18. modulability intraocular lens according to claim 1, wherein the fluid reservoir room is included in inner corrugations area Submissive fold domain between domain and outer corrugations portion region, the submissive region is than the inner corrugations and the outside ripple Line portion is thin.

19. modulability intraocular lens according to claim 1, in addition to multiple protruding portion, the multiple protuberance connection It is connected to one or more of the first component or the second component and makes first lenticular unit and described second Lenticular unit is separated each other.

20. modulability intraocular lens according to claim 19, wherein the multiple protuberance portion is arranged on the ripple Between line portion region and the lens area.

21. modulability intraocular lens according to claim 19, wherein the multiple protuberance in the fluid cavity and Each defined between the fluid storage chamber in multiple fluid passages, the multiple fluid passage is defined in two adjacent protrusions Between portion.

22. modulability intraocular lens according to claim 1, wherein in the first component or the second component It is one or more including polymeric material.

23. modulability intraocular lens according to claim 22, wherein the polymeric material includes PMMA copolymers.

24. modulability intraocular lens according to claim 22, wherein the polymeric material is water penetration.

25. modulability intraocular lens according to claim 22, wherein the polymeric material is hydrophilic.

26. modulability intraocular lens according to claim 22, wherein the polymeric material is configured to adjust when described When section property intraocular lens is placed in lens capsule, the water in the lens capsule of subject is set to turn through the polymeric material Move on in one or more of the fluid cavity or the fluid storage chamber or from one in the fluid cavity or fluid storage chamber Or it is multiple in be transferred out to realize osmotic equilibrium.

27. modulability intraocular lens according to claim 22, wherein the polymeric material is more than to molecular weight 40kDa compound is impermeable.

28. the fluid in modulability intraocular lens according to claim 1, in addition to the fluid cavity, wherein described Fluid is included in solution, oil, silicone oil, dextran solution, high-molecular-weight dextran solution or other high-molecular weight compounds solution One or more.

29. modulability intraocular lens according to claim 1, wherein the fluid reservoir room includes surrounding the fluid cavity Periphery set continuous baffle arrangement.

30. modulability intraocular lens according to claim 29, wherein the continuous structure include annular, ellipse or One or more in non-rotational symmetric shape.

31. modulability intraocular lens according to claim 1, wherein the first component and the second component are foots Enough flexible is configured with the delivering for being folded into cross section reduction.

32. modulability intraocular lens according to claim 31, wherein the delivering configuration that the cross section reduces includes The one or more folding parts for surrounding delivering axis or rolling volume portion of the intraocular lens, the delivering axis is transverse to described The optical axis of modulability intraocular lens.

33. modulability intraocular lens according to claim 31, in addition to delivery tube or hole, and it is wherein described transversal The delivering configuration that face reduces includes the intraocular lens advanced into the delivery tube or hole.

34. modulability intraocular lens according to claim 1, wherein the fluid reservoir room includes haptic configuration to engage The lens capsule.

35. modulability intraocular lens according to claim 1, wherein the fluid in the fluid cavity, which has, is more than eyes Aqueous humor about 1.336 refractive index refractive index.

36. modulability intraocular lens according to claim 1, wherein first lens area or second lens Region does not provide focal power.

37. modulability intraocular lens according to claim 1, wherein the fluid in the fluid cavity provides focal power.

38. modulability intraocular lens according to claim 1, wherein first lenticular unit and second lens Part is bonded to each other.

39. modulability intraocular lens according to claim 32, wherein first lenticular unit and described second saturating Mirror element includes polymeric material, and wherein described first lenticular unit and second lenticular unit pass through polymeric material Prepolymer combine.

40. modulability intraocular lens according to claim 1, wherein first lenticular unit or second lens One or more of part is manufactured directly.

41. modulability intraocular lens according to claim 1, wherein first lenticular unit and second lens Part is manufactured directly together and including single workpiece.

42. modulability intraocular lens according to claim 1, wherein first lenticular unit and second lens Part is individually moulded and is combined together.

43. modulability intraocular lens according to claim 1, wherein first lenticular unit and second lens Part is by individually lathe process and is combined together.

44. modulability intraocular lens according to claim 1, wherein first lenticular unit and second lens Part is combined together at protuberance, and the protuberance extends between the first component and the second component.

45. modulability intraocular lens according to claim 1, wherein first lenticular unit includes the first manufacture Part, and second lenticular unit includes the second manufacture parts.

46. a kind of method, methods described includes providing the modulability intraocular lens as any one of preceding claims.

47. a kind of method that eyes for subject provide regulation, methods described includes：

Received with the external fluid storage chamber for the modulability intraocular lens being placed in the lens capsule of eyes from crystalline The compression stress of the change of somatocyst；

In response to the compression stress of the change received, in the inner-fluid chamber and the outside stream of the modulability intraocular lens Fluid is promoted between the corrugated part region of body storage chamber, the optical axis that the corrugated part region includes surrounding the intraocular lens is continuous The folding part of circumferentially extending；And

Fluid in response to being pushed to or promoting out the inner-fluid chamber, changes the size or shape of the inner-fluid chamber One or more of, to change the focal power of the modulability intraocular lens.

48. fluid connects each other for method according to claim 47, wherein inner corrugations region and outer corrugations portion region Lead to and be in fluid communication with the inner-fluid chamber.

49. method according to claim 47, wherein one or more of described corrugated part region is ring in shape It is shape, ellipse or rotationally symmetrical.

50. method as claimed in claim 47, wherein the fluid reservoir room includes haptic configuration, to engage lens capsule.

51. method according to claim 47, wherein one in changing the size or shape of the inner-fluid chamber or Multiple spacing distances including changing between the first lens area and the part of the second lens area.

52. method according to claim 47, wherein one in changing the size or shape of the inner-fluid chamber or The song of one or more of multiple the first lens areas or the second lens area that the inner-fluid chamber is defined including changing Rate radius.

53. method according to claim 47, wherein the modulability intraocular lens include defining the internal flow One in the first lens area and the second lens area of chamber, and first lens area or second lens area Or multiple plano-convex components including being configured to provide minimum power to the modulability intraocular lens.

54. method according to claim 47, wherein the inner-fluid chamber includes the fluid being located therein, and it is described Inner-fluid chamber provides shape to the fluid so that the fluid provides focal power for the modulability intraocular lens.

55. method according to claim 47, wherein increasing the compression stress of the change by fluid forces to the inside In fluid cavity.