CN107011287A - 2‑哌嗪‑1‑基‑4h‑1,3‑苯并噻嗪‑4‑酮衍生物及其用于治疗哺乳动物感染的用途 - Google Patents

2‑哌嗪‑1‑基‑4h‑1,3‑苯并噻嗪‑4‑酮衍生物及其用于治疗哺乳动物感染的用途 Download PDF

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Publication number
CN107011287A
CN107011287A CN201710192245.2A CN201710192245A CN107011287A CN 107011287 A CN107011287 A CN 107011287A CN 201710192245 A CN201710192245 A CN 201710192245A CN 107011287 A CN107011287 A CN 107011287A
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CN
China
Prior art keywords
compound
benzothiazin
trifluoromethyl
piperazine
broad
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Pending
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CN201710192245.2A
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English (en)
Chinese (zh)
Inventor
V·马卡洛瓦
S·科尔
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Ecole Polytechnique Federale de Lausanne EPFL
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Ecole Polytechnique Federale de Lausanne EPFL
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Publication of CN107011287A publication Critical patent/CN107011287A/zh
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A61K31/5415—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with carbocyclic ring systems, e.g. phenothiazine, chlorpromazine, piroxicam
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A61P31/06—Antibacterial agents for tuberculosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A61P31/08—Antibacterial agents for leprosy
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D279/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one sulfur atom as the only ring hetero atoms
    • C07D279/04—1,3-Thiazines; Hydrogenated 1,3-thiazines
    • C07D279/08—1,3-Thiazines; Hydrogenated 1,3-thiazines condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
  • Plural Heterocyclic Compounds (AREA)
CN201710192245.2A 2010-11-19 2011-11-21 2‑哌嗪‑1‑基‑4h‑1,3‑苯并噻嗪‑4‑酮衍生物及其用于治疗哺乳动物感染的用途 Pending CN107011287A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
RU2010000688 2010-11-19
RUPCT/RU2010/000688 2010-11-19
CN2011800558135A CN103221399A (zh) 2010-11-19 2011-11-21 2-哌嗪-1-基-4h-1,3-苯并噻嗪-4-酮衍生物及其用于治疗哺乳动物感染的用途

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
CN2011800558135A Division CN103221399A (zh) 2010-11-19 2011-11-21 2-哌嗪-1-基-4h-1,3-苯并噻嗪-4-酮衍生物及其用于治疗哺乳动物感染的用途

Publications (1)

Publication Number Publication Date
CN107011287A true CN107011287A (zh) 2017-08-04

Family

ID=45349249

Family Applications (2)

Application Number Title Priority Date Filing Date
CN201710192245.2A Pending CN107011287A (zh) 2010-11-19 2011-11-21 2‑哌嗪‑1‑基‑4h‑1,3‑苯并噻嗪‑4‑酮衍生物及其用于治疗哺乳动物感染的用途
CN2011800558135A Pending CN103221399A (zh) 2010-11-19 2011-11-21 2-哌嗪-1-基-4h-1,3-苯并噻嗪-4-酮衍生物及其用于治疗哺乳动物感染的用途

Family Applications After (1)

Application Number Title Priority Date Filing Date
CN2011800558135A Pending CN103221399A (zh) 2010-11-19 2011-11-21 2-哌嗪-1-基-4h-1,3-苯并噻嗪-4-酮衍生物及其用于治疗哺乳动物感染的用途

Country Status (19)

Country Link
US (1) US8796264B2 (https=)
EP (1) EP2640712B1 (https=)
JP (1) JP6061346B2 (https=)
KR (2) KR101851774B1 (https=)
CN (2) CN107011287A (https=)
AU (1) AU2011330742B2 (https=)
BR (1) BR112013012280B1 (https=)
CA (1) CA2817931C (https=)
EA (1) EA023879B1 (https=)
ES (1) ES2690728T3 (https=)
GE (1) GEP201606545B (https=)
HU (1) HUE040152T2 (https=)
IL (1) IL226289A (https=)
LT (1) LT2640712T (https=)
PL (1) PL2640712T3 (https=)
TR (1) TR201815010T4 (https=)
UA (1) UA109557C2 (https=)
WO (1) WO2012066518A1 (https=)
ZA (1) ZA201303829B (https=)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103508980B (zh) * 2012-06-14 2016-07-06 四川大学 苯并噻嗪-4-酮衍生物及其制备方法和用途
CN104211708B (zh) * 2013-05-29 2018-08-24 中国医学科学院药物研究所 苯并噁嗪酮衍生物及其作为抗菌剂的应用
CN106659716B (zh) 2014-01-24 2021-03-12 人工智能治疗公司 阿吡莫德组合物及其使用方法
DE102014012546A1 (de) * 2014-09-26 2016-03-31 Martin-Luther-Universität Halle-Wittenberg Antimykobakteriell wirksame Substanzen, Verfahren zu ihrer Herstellung und deren Verwendung
US10206910B2 (en) 2014-11-07 2019-02-19 Lam Therapeutics, Inc. Apilimod for use in the treatment of renal cancer
EP3072889A1 (en) * 2015-03-23 2016-09-28 Ecole Polytechnique Federale De Lausanne (Epfl) 2-Homopiperazine-1-yl-4H-1,3-benzothiazine-4-one derivatives and process for the preparation of 2-(homo)piperazine 1,3-benzothiazine-4-one hydrochlorides
RU2752568C2 (ru) * 2016-09-22 2021-07-29 Ляйбниц-Институт Фюр Натурштофф-Форшунг Унд Инфекционсбиологи Е.Ф. Ханс-Кнёлль Институт (Хки) Новые антимикробные соединения, их применение для лечения инфекций млекопитающих и новый метаболический механизм
CN108929329B (zh) * 2017-05-24 2020-12-11 中国医学科学院药物研究所 2-氮杂环-5-三氟甲基-8-硝基苯并(硫代)吡喃-4-酮类化合物
RU2751163C9 (ru) * 2020-04-06 2021-10-20 Общество С Ограниченной Ответственностью "Ниармедик Плюс" Фармацевтическая композиция на основе макозинона для лечения туберкулеза, включая его формы с множественной и широкой лекарственной устойчивостью.
CN111303075A (zh) * 2020-04-08 2020-06-19 苏州大学 苯并噻嗪酮衍生物及其制备方法与作为抗结核药物的应用
KR102409518B1 (ko) 2020-06-22 2022-06-17 조은바이오주식회사 대량의 하천수를 저장하여 인공양어장을 조성함과 동시에 미세먼지 발생량을 줄여주도록 유도시켜서 대기중의 오염된 공기를 개선시킴과 동시에 비중이 무거운 깨끗한 물 분자를 우선적으로 배출하여 오염된 하천수를 깨끗한 하천수로 정화시키도록 구성되는 자연친화적인 친환경 저수시스템을 이용하여 대량의 전기를 생산하면서 저수지, 호수,댐, 석호,하천,강의 수질을 자연정화시키는 자연친화적인 수질정화 친환경공법

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007134625A1 (en) * 2006-05-24 2007-11-29 Leibniz Institute For Natural Product Research And Infection Biology E.V. Hans-Knöll-Institut (Hki) New benzothiazinone derivatives and their use as antibacterial agents
WO2009010163A1 (en) * 2007-07-16 2009-01-22 Leibniz-Institut Für Naturstoff-Forschung Und Infektionsbiologie E.V. Hans-Knöll-Institut New antimicrobial compounds, their synthesis and their use for treatment of mammalian infections
CN102367239A (zh) * 2011-07-20 2012-03-07 沈阳药科大学 2-芳基-2,3-二氢-4h-1,3-苯并噻嗪-4-酮衍生物及其用途

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3470168A (en) * 1967-03-31 1969-09-30 American Home Prod 2-substituted-4h-1,3-benzothiazin-4-one derivatives
US3522247A (en) 1967-11-07 1970-07-28 Pfizer & Co C 2-amino-6,7-disubstituted-4h-1,3-benzothiazine-4-ones as bronchodilators
EP2380886A1 (en) * 2010-04-23 2011-10-26 Vadim A. Makarov Process for the preparation of 2-aminosubstituted 1,3-benzothiazine-4-ones

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007134625A1 (en) * 2006-05-24 2007-11-29 Leibniz Institute For Natural Product Research And Infection Biology E.V. Hans-Knöll-Institut (Hki) New benzothiazinone derivatives and their use as antibacterial agents
WO2009010163A1 (en) * 2007-07-16 2009-01-22 Leibniz-Institut Für Naturstoff-Forschung Und Infektionsbiologie E.V. Hans-Knöll-Institut New antimicrobial compounds, their synthesis and their use for treatment of mammalian infections
CN102367239A (zh) * 2011-07-20 2012-03-07 沈阳药科大学 2-芳基-2,3-二氢-4h-1,3-苯并噻嗪-4-酮衍生物及其用途

Also Published As

Publication number Publication date
AU2011330742B2 (en) 2016-10-13
EA201390639A1 (ru) 2013-09-30
TR201815010T4 (tr) 2018-11-21
KR20140012956A (ko) 2014-02-04
IL226289A (en) 2016-07-31
US20130245007A1 (en) 2013-09-19
AU2011330742A1 (en) 2013-06-27
KR101871970B1 (ko) 2018-08-02
KR101851774B1 (ko) 2018-04-25
WO2012066518A1 (en) 2012-05-24
CN103221399A (zh) 2013-07-24
US8796264B2 (en) 2014-08-05
JP2013542980A (ja) 2013-11-28
LT2640712T (lt) 2018-11-12
BR112013012280A2 (pt) 2020-09-01
CA2817931A1 (en) 2012-05-24
IL226289A0 (en) 2013-07-31
EP2640712B1 (en) 2018-07-11
CA2817931C (en) 2017-10-31
KR20170137211A (ko) 2017-12-12
PL2640712T3 (pl) 2019-03-29
EP2640712A1 (en) 2013-09-25
ES2690728T3 (es) 2018-11-22
ZA201303829B (en) 2014-01-29
JP6061346B2 (ja) 2017-01-18
GEP201606545B (en) 2016-09-26
BR112013012280B1 (pt) 2022-01-04
EA023879B1 (ru) 2016-07-29
UA109557C2 (uk) 2015-09-10
HUE040152T2 (hu) 2019-02-28

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Application publication date: 20170804

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