CN107007731B - 一种治疗结膜炎的中药组合物及制备方法 - Google Patents
一种治疗结膜炎的中药组合物及制备方法 Download PDFInfo
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Abstract
本发明公开了一种治疗结膜炎的中药组合物,属于医药技术领域。该治疗结膜炎的中药组合物由以下重量份的原料制成:锦灯笼8‑12份、密蒙花6‑10份、决明子8‑12份、熟地黄5‑10份、蝉蜕3‑6份、梅片3‑6份、炙甘草3‑6份、谷精草8‑12份、知母8‑12份、白芷3‑6份、槟榔3‑6份。本发明的治疗结膜炎的中药组合物清热泻火,能够有效缓解眼部疲劳、消除眼部干涩红肿、眼痒、视物模糊等不适症状,所选药物配伍相宜,疗效显著,安全性高,长时间使用不会产生依赖症。
Description
技术领域
本发明涉及医药技术领域,具体涉及一种治疗结膜炎的中药组合物及制备方法。
背景技术
结膜炎是结膜组织在外界和机体自身因素的作用而发生的炎性反应的统称。虽然结膜炎本身对视力影响并不严重,但是当其炎症波及角膜或引起并发症时,可导致视力的损害。根据结膜炎的病情及病程,可分为急性、亚急性和慢性三类。其中,急性结膜炎眼睛起初常有异物感、烧灼、刺痛以及畏光等症状,继而引发眼睛结膜充血以及粘液性分泌物逐渐增多。
因此发明一种疗效显著的治疗结膜炎的中药组合物具有很大的实用价值。
发明内容
本发明提供一种治疗结膜炎的中药组合物,可以解决现有技术中的上述问题。
本发明提供了一种治疗结膜炎的中药组合物,由以下重量份的原料制成:锦灯笼8-12份、密蒙花6-10份、决明子8-12份、熟地黄5-10份、蝉蜕3-6份、梅片3-6份、炙甘草3-6份、谷精草8-12份、知母8-12份、白芷3-6份、槟榔3-6份。
较佳地,所述治疗结膜炎的中药组合物由以下重量份的原料制成:锦灯笼10份、密蒙花8份、决明子10份、熟地黄8份、蝉蜕5份、梅片5份、炙甘草5份、谷精草10份、知母10份、白芷5份、槟榔5份。
较佳地,所述治疗结膜炎的中药组合物由以下重量份的原料制成:锦灯笼9份、密蒙花8份、决明子10份、熟地黄6份、蝉蜕4份、梅片6份、炙甘草4份、谷精草11份、知母9份、白芷4份、槟榔4份。
较佳地,所述治疗结膜炎的中药组合物由以下重量份的原料制成:锦灯笼10份、密蒙花10份、决明子9份、熟地黄7份、蝉蜕5份、梅片4份、炙甘草6份、谷精草9份、知母12份、白芷6份、槟榔6份。
本发明提供了所述治疗结膜炎的中药组合物的制备方法,包括以下步骤:
步骤1:将各个所述原料干燥、粉碎至80-120目粉末备用;
步骤2:按重量份称取各个所述原料的粉末,混匀,然后加入总粉末重量的8-10倍的水,浸泡2-4小时,加热至沸腾,保温0.5-2小时,过滤得滤液,分离出滤渣;
步骤3:将步骤2收集的滤渣,再加入总粉末重量的0.5~5倍水,煎煮0.5~2h,过滤,得到滤液,合并两次滤液,将滤液浓缩为之前体积的30-80%,待滤液降温至50-65℃,再加入占浓缩后的滤液体积40~60%的乙醇,进行醇沉,静置48h后减压回收乙醇;
步骤4:将步骤3醇沉之后的滤液浓缩至相对密度为1.08-1.18,得到提取液。
本医药中的各个原料的药理如下:
锦灯笼:甘,微苦,清香,辛,寒。归肺,胃,心,大肠经。既能宣散风热,还善清解解毒,用于各种热性病,如身热、发疹、发斑、热毒疮痈、咽喉肿痛等症。
密蒙花:性味苦,寒。清心,去热,止血,涩精。治心烦,口渴,吐血,遗精,平和五脏之气。
决明子:味甘、咸、苦,性微寒。归肝、大肠经。具有清肝明目、通便的功能。主治高血压、头痛、眩晕、急性结膜炎、角膜溃疡、青光眼、痈疖疮疡等症。
熟地黄:味甘;性温。归肝;肾经。补血滋润;益精填髓。用于血虚萎黄;眩晕心悸;月经不调;崩不止;肝肾阴亏;潮热盗汗;遗精阳痿;不育不孕;月经不调;崩漏下血;腰膝酸软;耳鸣耳聋;头目昏花;须发早白;消渴;便秘;肾虚喘促。
蝉蜕:咸、甘、寒、无毒。归肺、肝经。散风除热,利咽,透疹,退翳,解痉。用于风热感冒,咽痛,音哑,麻疹不透,风疹瘙痒,目赤翳障,惊风抽搐,破伤风。
梅片:气清香,味辛、苦、凉;归心、脾、肺经;主治通诸窍,散郁火,消肿止痛,去翳明目。用于中风口禁,惊痈痰迷。外用治喉痹齿痛,口疮痈痬,目赤肤翳。
炙甘草:含有甘草甜素、甘草次酸、甘草多糖等多种化学成分,具有抗炎及抗变态反应作用,可调节机体免疫功能,抗肿瘤和止痛作用。因此炙甘草的主要功效是和中缓急,润肺,解毒,调和诸药。常用于脾胃虚弱,倦怠乏力,心动悸,脉结代,可解附子毒。
谷精草:味辛,性寒凉,归肺经。能清热解毒、消肿疗疮、利尿除湿、清热止痢、健胃消食,用治实热、热毒、湿邪、疾热为患的肺痈、疮疡肿毒、痔疮便血、脾胃积热等。现代药理实验表明,本品具有抗菌、抗病毒、提高机体免疫力、利尿等作用。
知母:味苦、甘,性寒,入肺、胃、肾经,有泻热除烦,滋阴润燥、清肺止咳的作用,主治外感热病,高热烦躁,肺热燥咳,内热消渴等症状;其苦寒质润,性沉降,既能清热,又能生津,善治温热病邪入气分,热盛伤津;也用于治疗消渴症;痰热壅肺而喘,肺燥咳嗽,痰少不利;阴虚火旺,虚火上炎等症状。
白芷:性温,味辛,气芳香,微苦。功能主治:祛风湿,活血排脓,生肌止痛。用于头痛、牙痛、鼻渊、肠风痔漏、赤白带下、痈疽疮疡、皮肤瘙痒。
槟榔:味苦,辛,性温。归胃、大肠经。驱虫;消积;下气;行水;截疟。虫积;食滞;脘腹胀痛;泻痢后重;脚气;水肿;疟疾。
与现有技术相比,本发明的有益效果是:本发明的治疗结膜炎的中药组合物清热泻火,能够有效缓解眼部疲劳、消除眼部干涩红肿、眼痒、视物模糊等不适症状,所选药物配伍相宜,疗效显著,安全性高,长时间使用不会产生依赖症。
具体实施方式
下面对本发明的具体实施方式进行详细描述,但应当理解本发明的保护范围并不受具体实施方式的限制。基于本发明中的实施例,本领域普通技术人员在没有做出创造性劳动的前提下所获得的所有其他实施例,都属于本发明保护的范围。
实施例1:
一种治疗结膜炎的中药组合物,由以下重量份的原料制成:锦灯笼10份、密蒙花8份、决明子10份、熟地黄8份、蝉蜕5份、梅片5份、炙甘草5份、谷精草10份、知母10份、白芷5份、槟榔5份。
实施例2:
一种治疗结膜炎的中药组合物,由以下重量份的原料制成:锦灯笼9份、密蒙花8份、决明子10份、熟地黄6份、蝉蜕4份、梅片6份、炙甘草4份、谷精草11份、知母9份、白芷4份、槟榔4份。
实施例3:
一种治疗结膜炎的中药组合物,由以下重量份的原料制成:锦灯笼10份、密蒙花10份、决明子9份、熟地黄7份、蝉蜕5份、梅片4份、炙甘草6份、谷精草9份、知母12份、白芷6份、槟榔6份。
实施例4:
上述治疗结膜炎的中药组合物的制备方法包括以下步骤:
步骤1:将各个所述原料干燥、粉碎至80目粉末备用;
步骤2:按重量份称取各个所述原料的粉末,混匀,然后加入总粉末重量的10倍的水,浸泡3小时,加热至沸腾,保温1小时,过滤得滤液,分离出滤渣;
步骤3:将步骤2收集的滤渣,再加入总粉末重量的4倍水,煎煮1h,过滤,得到滤液,合并两次滤液,将滤液浓缩为之前体积的60%,待滤液降温至60℃,再加入占浓缩后的滤液体积50%的乙醇,进行醇沉,静置48h后减压回收乙醇;
步骤4:将步骤3醇沉之后的滤液浓缩至相对密度为1.10,得到提取液。
实施例5:
上述治疗结膜炎的中药组合物的制备方法包括以下步骤:
步骤1:将各个所述原料干燥、粉碎至80目粉末备用;
步骤2:按重量份称取各个所述原料的粉末,混匀,然后加入总粉末重量的9倍的水,浸泡2.5小时,加热至沸腾,保温1.5小时,过滤得滤液,分离出滤渣;
步骤3:将步骤2收集的滤渣,再加入总粉末重量的3倍水,煎煮0.5h,过滤,得到滤液,合并两次滤液,将滤液浓缩为之前体积的50%,待滤液降温至60℃,再加入占浓缩后的滤液体积55%的乙醇,进行醇沉,静置48h后减压回收乙醇;
步骤4:将步骤3醇沉之后的滤液浓缩至相对密度为1.15,得到提取液。
也可以采用本领域现有技术制成各种剂型,冲剂、胶囊和药片等。
临床应用
为了验证本发明的治疗结膜炎的中药组合物的治疗效果,我们选取100例患有剂型结膜炎的患者进行临床试验。
临床应用
为了验证本发明的中药组合物的治疗效果,我们选取100例(125眼)患有急性结膜炎的患者进行临床试验,症状体征为:发病急,病程短,自觉流泪、有异物感、干涩红肿、灼热感或痒痛等。结膜充血,分泌物多。
1、试验方法
取本发明实施例1采用实施例4的制备方法制备出的中药组合物30毫升,加入500毫升生理盐水中,结膜囊冲洗双眼约100毫升,每日2次,疗程3天,观察眼部症状及体征变化,疗程结束后判断疗效。
2、疗效判定标准
治愈:症状体征全部消失。
有效:全部症状消失或主要症状体征消失。
无效:全部症状体征无改善,甚至加重。
3、试验结果
试验结果见表1。
表1试验组和对照组疗效结果
治愈眼数/只 | 有效眼数/只 | 无效眼数/只 | 总有效率/% |
106 | 19 | 0 | 100 |
结果分析:从表1可以看出,本发明的治疗结膜炎的中药组合物的有效率为100%,疗效显著。
一个月后随访上述患者,症状均没有复发。
下面列举几个典型病例以说明本中药组合物的有益效果。
1、李某,女,36岁,患者自述,从两天前开始双眼有异物感,涩痒,之后眼结膜变红,分泌物特别多,经诊断为急性结膜炎。用本发明实施例制备的药物,连续用药3天,症状全部消失。
2、郑某,男40岁,自述旅游回来,先左眼睛感到难受,后来眼睛变红,结膜充血,视物不清,之后右眼也出现上述症状,分泌物增多,经诊断为急性传染性结膜炎,服用本发明实施例2的药物,服用5天,症状减轻,后又服用2天,症状全部消失。
本发明的治疗结膜炎的中药组合物清热泻火,能够有效缓解眼部疲劳、消除眼部干涩红肿、眼痒、视物模糊等不适症状,所选药物配伍相宜,疗效显著,安全性高,长时间使用不会产生依赖症。
尽管已描述了本发明的优选实施例,但本领域内的技术人员一旦得知了基本创造性概念,则可对这些实施例作出另外的变更和修改。所以,所附权利要求意欲解释为包括优选实施例以及落入本发明范围的所有变更和修改。
显然,本领域的技术人员可以对本发明进行各种改动和变型而不脱离本发明的精神和范围。这样,倘若本发明的这些修改和变型属于本发明权利要求及其等同技术的范围之内,则本发明也意图包含这些改动和变型在内。
Claims (4)
1.一种治疗结膜炎的中药组合物,其特征在于,由以下重量份的原料制成:锦灯笼8-12份、密蒙花6-10份、决明子8-12份、熟地黄5-10份、蝉蜕3-6份、梅片3-6份、炙甘草3-6份、谷精草8-12份、知母8-12份、白芷3-6份、槟榔3-6份,包括以下步骤:
步骤1:将各个所述原料干燥、粉碎至80-120目粉末备用;
步骤2:按重量份称取各个所述原料的粉末,混匀,然后加入总粉末重量的8-10倍的水,浸泡2-4小时,加热至沸腾,保温0.5-2小时,过滤得滤液,分离出滤渣;
步骤3:将步骤2收集的滤渣,再加入总粉末重量的0.5~5倍水,煎煮0.5~2h,过滤,得到滤液,合并两次滤液,将滤液浓缩为之前体积的30-80%,待滤液降温至50-65℃,再加入占浓缩后的滤液体积40~60%的乙醇,进行醇沉,静置48h后减压回收乙醇;
步骤4:将步骤3醇沉之后的滤液浓缩至相对密度为1.08-1.18,得到提取液。
2.如权利要求1所述的治疗结膜炎的中药组合物,其特征在于,由以下重量份的原料制成:锦灯笼10份、密蒙花8份、决明子10份、熟地黄8份、蝉蜕5份、梅片5份、炙甘草5份、谷精草10份、知母10份、白芷5份、槟榔5份。
3.如权利要求1所述的治疗结膜炎的中药组合物,其特征在于,由以下重量份的原料制成:锦灯笼9份、密蒙花8份、决明子10份、熟地黄6份、蝉蜕4份、梅片6份、炙甘草4份、谷精草11份、知母9份、白芷4份、槟榔4份。
4.如权利要求1所述的治疗结膜炎的中药组合物,其特征在于,由以下重量份的原料制成:锦灯笼10份、密蒙花10份、决明子9份、熟地黄7份、蝉蜕5份、梅片4份、炙甘草6份、谷精草9份、知母12份、白芷6份、槟榔6份。
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