CN106901287A - A kind of Chinese medicinal alcoholism-relieving protect liver jelly and preparation method based on probiotics fermention - Google Patents

A kind of Chinese medicinal alcoholism-relieving protect liver jelly and preparation method based on probiotics fermention Download PDF

Info

Publication number
CN106901287A
CN106901287A CN201710161107.8A CN201710161107A CN106901287A CN 106901287 A CN106901287 A CN 106901287A CN 201710161107 A CN201710161107 A CN 201710161107A CN 106901287 A CN106901287 A CN 106901287A
Authority
CN
China
Prior art keywords
jelly
relieving
probiotics fermention
liver
alcoholism
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN201710161107.8A
Other languages
Chinese (zh)
Inventor
王艺霖
郝委委
谷劲松
单秋丽
陈珺楠
刘佳宁
王芬
李伟光
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Jinan
Original Assignee
University of Jinan
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of Jinan filed Critical University of Jinan
Priority to CN201710161107.8A priority Critical patent/CN106901287A/en
Publication of CN106901287A publication Critical patent/CN106901287A/en
Pending legal-status Critical Current

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/56Materials from animals other than mammals
    • A61K35/63Arthropods
    • A61K35/64Insects, e.g. bees, wasps or fleas
    • A61K35/644Beeswax; Propolis; Royal jelly; Honey
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/22Anacardiaceae (Sumac family), e.g. smoketree, sumac or poison oak
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/28Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A61K36/287Chrysanthemum, e.g. daisy
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/32Burseraceae (Frankincense family)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/42Cucurbitaceae (Cucumber family)
    • A61K36/424Gynostemma
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/48Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/488Pueraria (kudzu)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/60Moraceae (Mulberry family), e.g. breadfruit or fig
    • A61K36/605Morus (mulberry)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/62Nymphaeaceae (Water-lily family)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/72Rhamnaceae (Buckthorn family), e.g. buckthorn, chewstick or umbrella-tree
    • A61K36/725Ziziphus, e.g. jujube
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/73Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
    • A61K36/734Crataegus (hawthorn)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/73Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
    • A61K36/736Prunus, e.g. plum, cherry, peach, apricot or almond
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/81Solanaceae (Potato family), e.g. tobacco, nightshade, tomato, belladonna, capsicum or jimsonweed
    • A61K36/815Lycium (desert-thorn)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/88Liliopsida (monocotyledons)
    • A61K36/899Poaceae or Gramineae (Grass family), e.g. bamboo, corn or sugar cane
    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23VINDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2002/00Food compositions, function of food ingredients or processes for food or foodstuffs
    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23VINDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2400/00Lactic or propionic acid bacteria
    • A23V2400/21Streptococcus, lactococcus
    • A23V2400/249Thermophilus
    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23VINDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2400/00Lactic or propionic acid bacteria
    • A23V2400/51Bifidobacterium
    • A23V2400/517Bifidum
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30Extraction of the material
    • A61K2236/33Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/331Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction

Abstract

Efficient relieving alcoholism and protecting liver jelly and preparation method are prepared based on probiotics fermention herbal composite the invention discloses one kind; the traditional Chinese medicine ingredients of the jelly antialcoholism action are made up of Chinese medicine materials such as roselle, dracontomelon duperreanum, flower of kudzuvine, olive, dark plums; this product passes through probiotics fermention; with it is in good taste, dispelling effects of alcohol is obvious the characteristics of; the symptoms such as drunk rear digestive discomfort, headache can be alleviated; the wine that can disappear product, the polydipsia that disappears, dampness removing heat-clearing etc. are acted on, and have protective effect to liver.Gastrointestinal mucosa is protected in fruit juice gel quality guarantee, mitigates stimulation and damage of the alcohol to gastrointestinal mucosa, and protection and plerosis function are played in the position to having damaged.

Description

A kind of Chinese medicinal alcoholism-relieving protect liver jelly and preparation method based on probiotics fermention
Technical field
The present invention relates to food, the technical field of health care, specifically a kind of Antialcoholic liver-protecting jelly is mainly used in alleviation liquor-saturated Wine, replenish qi to invigorate the spleen, dampness elimination is quenched one's thirst.
Background technology
China is the native place of wine, is also the cradle of spirits culture, is one of earliest country of making wine in the world.Drink conduct A kind of culture of food, in the time immemorial generation be formed the courtesy that everybody has to comply with.Chinese's is hospitable, is played in feast Drip is drenched to cause to the greatest extent.The affection exchange of person to person is often elevated when toasting.When Chinese toast, often all thinking to drink other side more Wine, the friendship of owner oneself has been discharged to represent, guest drinks more, and owner is glaier.Whether friend's exchange or work Dinner party, it be all essential to be drunk, but part population is drunk easily liquor-saturated and can produce adverse reaction.
Alcohol is close nervous substances, and Central nervous have inhibitory action.One time heavy drinking can produce state of intoxication, be normal The acute alcoholism seen.The difference of everyone capacity for liquor size is the difference of its internal enzyme.Once internal enzyme is not enough to Decompose acetaldehyde, it will assemble acetaldehyde, our common drunk symptoms occur when a little.Will be endangered when acetaldehyde reaches a certain amount And life.
Many people drink do not drink, drink how much wine with it is whether sincere, whether loyal to one's friends, whether have the ability to connect, this It is one of major reason that compatriots' alcoholism occurs repeatedly.
Some countries(Such as Europe, America)Acute alcoholism generation it is very universal, be to be only second to painstaking effort in the U.S. Pipe disease, tumour and occupy the public health event of the 3rd.China has document report patients with acute alcoholism to account for same period urgency The 0.5% of patient is examined, the 49% of patients with acute intoxication is accounted for.The present invention plays prevention acute alcoholism effect according to theory of traditional Chinese medical science.
Disintoxicating product is inconvenient to carry based on the medicine that relieves the effect of alcohol, health products, drink in the market, and moulding is not attractive in appearance enough.This A kind of new jelly that relieves the effect of alcohol of invention, compact can be carried with, appearance looks elegant, can be positioned in hotel's dining service plate, Taken when needing to sober up, good drug efficacy, instant effect, meanwhile, oral mouthfeel is improved.
The content of the invention
Present invention aim at a kind of Antialcoholic liver-protecting jelly with health role is provided, the jelly that relieves the effect of alcohol has various solutions Into being grouped into, effect becomes apparent from wine during with sobering-up functions, especially disposable heavy drinking well.
The technical scheme is that:
A kind of Chinese medicinal alcoholism-relieving protect liver jelly based on probiotics fermention, the composition of its traditional Chinese medicine ingredients includes following originals by weight Material:9~15g of roselle, 10~15g of dracontomelon duperreanum, 3~12g of flower of kudzuvine, 6~12g of olive, 6~12g of dark plum, 10~15g of chrysanthemum, mulberry 10~15g of Shen, 15~30g of rhizoma imperatae, 10~15g of honey, 6~9g of water lily, 15~30g of gynostemma pentaphylla, hawthorn 5-20g, the fruit of Chinese wolfberry 15-20g, sucrose 5-10g.
Preferably, the composition of its traditional Chinese medicine ingredients is following raw materials by weight:Roselle 15g, dracontomelon duperreanum 10g, Pueraria lobota Flower 12g, olive 10g, dark plum 10g, chrysanthemum 15g, mulberries 10g, rhizoma imperatae 15g, honey 15g, water lily 9g, gynostemma pentaphylla 20g, hawthorn 5-20g, fruit of Chinese wolfberry 15-20g, sucrose 5-10g.
Further preferably, wherein the raw material of traditional Chinese medicine ingredients also includes 10~15g of spina date seed.
Further preferably, its traditional Chinese medicine ingredients composition is following components by weight:Roselle 15g, dracontomelon duperreanum 10g, Pueraria lobota Flower 12g, olive 10g, dark plum 10g, chrysanthemum 15g, mulberries 10g, rhizoma imperatae 15g, spina date seed 10g, honey 15g, water lily 9g, strand Blue 20g, hawthorn 5-20g, fruit of Chinese wolfberry 15-20g, sucrose 5-10g.
Present invention also offers a kind of preparation method of the Chinese medicinal alcoholism-relieving protect liver jelly based on probiotics fermention, specific steps It is as follows:
(1)The chinese medicine material in addition to sucrose in formula, plus 1L water are weighed, after being cooked by slow fire 45 minutes, the dregs of a decoction is filtered off, soup is made Agent;Sucrose is added, pH to 7.0 is adjusted with NaOH;Gained mixture autoclaving 30 minutes at 115 DEG C, obtain decoction mixing Thing;
(2)With MRS culture mediums activate bifidobacterium bifidum, lactobacillus acidophilus, with LB culture mediums activate Bacillus subtillis, and with The % of percentage by volume 0.1% to 10 is inoculated into decoction mixture, the inoculation solution is placed in into constant-temperature table culture, and be fermented into , at 25 DEG C -37 DEG C, the time is 3-4 days, is derived from target liq probiotics fermention herbal composite for liquid, culture and fermentation Liquid, it is standby;
(3)Water and agar are put into pot, are heated while stir, all after dissolving, added citric acid and be allowed to dissolve;
(4)50 DEG C are cooled to, probiotics fermention herbal composite liquid is added, stirred;
(5)Add honey and hyaluronic acid is mixed thoroughly, jelly is made with Jelly machine.
As further restriction:Relieving alcoholism and protecting liver jelly is formulated composition by weight:Probiotics fermention herbal composite Liquid 10-20%, hyaluronic acid 0.5-1%, agar 0.15-0.5%, citric acid 0.15%, water adds to 100%.
Each property of raw material of jelly composition is as follows in detail in the present invention:
Roselle:Property is sour, cool;Return kidney channel;Kidney channel;With relieving the effect of alcohol, astringe the lung to stop cough, hypotensive the effect of.
Dracontomelon duperreanum:Property is sweet, sour, cool;Returns spleen, stomach, Liver Channel;With stomach invigorating, promote the production of body fluid, sober up, detoxify the effect of.
Flower of kudzuvine:Nature and flavor are sweet, flat, enter spleen, stomach.The effect of with activating spleen by relieving alcoholism.It is mainly used in insobriety and injures stomach Qi Headache, giddy, polydipsia, the glutted, acid regurgitation of chest diaphragm etc..
Olive:Property is sweet, sour, puckery, mild-natured;Return lung, stomach, spleen, Liver Channel;With removing heat from the lung and relieving sorethroat, promote the production of body fluid to quench thirst, detoxify.Master coughs Cough phlegm blood;Abscess of throat;Hot summer weather polydipsia;It is drunk;Fish and crab poisoning.
Dark plum:Nature and flavor are sour, flat;Enter liver, spleen, lung, large intestine channel;With the effects such as promoting the production of body fluid of astringing the lung, can be used for the treatment deficiency syndrome of the lung long Cough, the disease such as protracted dysentery and diarrhea, abnormal heat are quenched one's thirst.Can be promoted the production of body fluid to quench thirst because its is sour, therefore drunk polydipsia can be solved.
Chrysanthemum:Property is bitter, pungent, is slightly cold;Return liver, the heart channel of Hang-Shaoyin;With dispelling wind and heat from the body, flat liver improving eyesight, clearing heat and detoxicating effect.Can control and drink The diseases such as headache, the giddy that degree causes.
Mulberries:Also known as sorosis, its nature and flavor is sweet, cold;Enter the heart, liver and kidney channel;With nourishing yin and supplementing blood, ease constipation effect of promoting the production of body fluid.Can relieve the effect of alcohol.
Rhizoma imperatae:Also known as root of couch grass, its nature and flavor is sweet, cold;Enter lung, stomach, bladder warp;With cooling blood and hemostasis, reducing fever and causing diuresis it Effect.Can relieving alcoholism.
Spina date seed:Property is sweet, sour, flat;The thoughts of returning home, spleen, liver, gallbladder channel;With nourishing the liver, calming heart is calmed the nerves, the effect of arrest sweating.
Honey:Property is sweet, flat;Return lung, spleen, large intestine channel;With bowl spares, moisturize, relieve pain, the effect of removing toxic substances.For the empty pain of gastral cavity abdomen, Dryness of the lung dry cough, dry constipation of intestines;Control sore outward not hold back, scald.
Water lily:Property is sweet, bitter, flat;Return liver, the spleen channel;With relieving summer heat, relieve the effect of alcohol, the effect of arresting convulsion.Can be used for heatstroke, drunk polydipsia.
Gynostemma pentaphylla:It is property hardship, micro-sweet, cool in nature;Return lung, spleen, kidney channel;With heat-clearing, qi-restoratives, removing toxic substances, promote uric acid excretion it Effect.
Hawthorn:Property acid is sweet, tepor, returns spleen, stomach, Liver Channel.For meat stagnation, gastric ulcer fullness, diarrhea dysentery abdominal pain, trusted subordinate's thorn Bitterly, hyperlipemia.
The fruit of Chinese wolfberry:Property is sweet, flat.With the effect that nourishing the liver, nourshing kidney, moistening lung, qi-restoratives strengthening the essence, heat-clearing improving eyesight are promoted the production of body fluid, sobered up.
Hyaluronic acid can protect gastrointestinal mucosa, mitigate stimulation and damage of the alcohol to gastrointestinal mucosa, to the portion damaged Play protection and plerosis function in position.Hyaluronic acid is a kind of direct-connected polymeric acidic mucopolysaccharide, after it absorbs moisture, can be formed The harmful substances such as network structure, absorption alcohol;Hyaluronic acid can also be dispersed in the space of Chinese medicinal liquor, using Chinese medicinal liquor Gap structure and the network structure of hyaluronic acid reach the purpose of the harmful substance such as dual absorption and synergistic sorption alcohol, absorption Afterwards, excreted by enteron aisle.
Beneficial effects of the present invention are:
The invention provides a kind of Chinese medicinal alcoholism-relieving protect liver jelly based on probiotics fermention, using medicinal herb componentses and transparent acid esters Coordinated, hyaluronic acid can form stomach diaphragm, protect stomach, reach sober-up function so that the effect of traditional Chinese medicine ingredients Give full play to, both added the novel taste of jelly, be also suitable for user and take, be happy to take, and the purpose with Antialcoholic liver-protecting, It is anti-to be still drank after a night, protect cardiovascular health;It is innovative in the present invention to introduce.
Brief description of the drawings
Fig. 1:The enzyme activity of ADH in mouse liver lapping liquid.
Fig. 2:The enzyme activity of ALDH in mouse liver lapping liquid.
Specific embodiment
The present invention is described in further details with reference to embodiment, but is not limitation of the invention.
Embodiment 1
The jelly traditional Chinese medicine ingredients formula that relieves the effect of alcohol is:Roselle 15g, dracontomelon duperreanum 10g, flower of kudzuvine 12g, olive 10g, dark plum 10g, chrysanthemum 15g, mulberries 10g, rhizoma imperatae 15g, spina date seed 10g, honey 15g, water lily 9g, gynostemma pentaphylla 20g, hawthorn 20g, fruit of Chinese wolfberry 15g, sugarcane Sugared 10g.
Preparation method is:Weigh the chinese medicine material in addition to sucrose in being formulated, plus 1L water, after being cooked by slow fire about 45 minutes, filter The dregs of a decoction are removed, decoction is made;Sucrose is added, pH to 7.0 is adjusted with NaOH;Gained mixture at 115 DEG C in autoclaving 30 minutes, Obtain decoction mixture;Bifidobacterium bifidum, lactobacillus acidophilus are activated with MRS culture mediums, Ko subtilis are activated with LB culture mediums Bacillus, and be inoculated into decoction mixture with the % of percentage by volume 0.1% to 10, by the inoculation solution as constant-temperature table culture, And liquid is fermented into, at 25 DEG C -37 DEG C, the time is 3-4 days for culture and fermentation, is derived from target liq 500ml probiotics hair Ferment herbal composite liquid.Water and agar are put into pot, are heated while stir, all after dissolving, add lemon Acid is allowed to dissolve;50 DEG C are cooled to, probiotics fermention herbal composite liquid is added, stirred;Add honey and thoroughly Bright matter acid is mixed thoroughly, and jelly is made with Jelly machine.
Relieving alcoholism and protecting liver jelly is formulated composition by weight:Probiotics fermention herbal composite liquid 10-20% is transparent Matter acid 0.5-1%, agar 0.15-0.5%, citric acid 0.15%, water adds to 100%.
Drunk person is allowed to take product 300g, more on a small quantity, 30min or so can relieve the effect of alcohol.
Embodiment 2
The jelly traditional Chinese medicine ingredients formula that relieves the effect of alcohol is:Roselle 10g, dracontomelon duperreanum 15g, flower of kudzuvine 5g, olive 8g, dark plum 12g, chrysanthemum 15g, Mulberries 10g, rhizoma imperatae 30g, spina date seed 15g, honey 15g, water lily 9g, gynostemma pentaphylla 30g, hawthorn 5g, fruit of Chinese wolfberry 20g, sucrose 5g.
Preparation method is:Weigh the chinese medicine material in addition to sucrose in being formulated, plus 1L water, after being cooked by slow fire about 45 minutes, filter The dregs of a decoction are removed, decoction is made;Sucrose is added, pH to 7.0 is adjusted with NaOH;Gained mixture at 115 DEG C in autoclaving 30 minutes, Obtain decoction mixture;Bifidobacterium bifidum, lactobacillus acidophilus are activated with MRS culture mediums, Ko subtilis are activated with LB culture mediums Bacillus, and be inoculated into decoction mixture with the % of percentage by volume 0.1% to 10, by the inoculation solution as constant-temperature table culture, And liquid is fermented into, at 25 DEG C -37 DEG C, the time is 3-4 days for culture and fermentation, is derived from target liq 500ml probiotics hair Ferment herbal composite liquid.Water and agar are put into pot, are heated while stir, all after dissolving, add lemon Acid is allowed to dissolve;50 DEG C are cooled to, probiotics fermention herbal composite liquid is added, stirred;Add honey and thoroughly Bright matter acid is mixed thoroughly, and jelly is made with Jelly machine.
Relieving alcoholism and protecting liver jelly is formulated composition by weight:Probiotics fermention herbal composite liquid 10-20% is transparent Matter acid 0.5-1%, agar 0.15-0.5%, citric acid 0.15%, water adds to 100%.
Allowing drunk person to take the product 300g, 30min or so can relieve the effect of alcohol.
Test example 1
Relieve the effect of alcohol influence of the jelly to alcohol dehydrogenase and aldehyde dehydrogenase activity in acute alcoholism mice liver.
Healthy male mice in kunming(Shandong University's Experimental Animal Center), 20-25g of body weight.Mouse is randomly divided into four Group, every group 20, gavage volume is 0.1g/10g, such as table 1 below:
The mouse experiment of table 1 is grouped and gavage volume
Buy Mouse feeder one week, each group mouse is run out of grain 12 h that do not cut off the water supply after one week, the disposable gavage of each group exists respectively Mouse is put to death after 20min, 40min, 60min, 80min, 100min, liver is taken immediately, weighed, by 1:10 add precooling 1.5% Klorvess Liquid is respectively prepared liver tissue homogenate.NADH methods determine hepatic tissue ADH and ALDH activity.See Fig. 1 and Fig. 2. As seen from the figure, the enzyme activity of jelly group mouse ADH and ALDH of relieving the effect of alcohol has rising in various degree, illustrates that this jelly that relieves the effect of alcohol has significantly Dispelling effects of alcohol.

Claims (6)

1. a kind of Chinese medicinal alcoholism-relieving protect liver jelly based on probiotics fermention, it is following that the composition of its traditional Chinese medicine ingredients includes by weight Raw material:9~15g of roselle, 10~15g of dracontomelon duperreanum, 3~12g of flower of kudzuvine, 6~12g of olive, 6~12g of dark plum, 10~15g of chrysanthemum, 10~15g of mulberries, 15~30g of rhizoma imperatae, 10~15g of honey, 6~9g of water lily, 15~30g of gynostemma pentaphylla, hawthorn 5-20g, matrimony vine Sub- 15-20g, sucrose 5-10g.
2. Chinese medicinal alcoholism-relieving protect liver jelly according to claim 1, the composition of its traditional Chinese medicine ingredients is following originals by weight Material:Roselle 15g, dracontomelon duperreanum 10g, flower of kudzuvine 12g, olive 10g, dark plum 10g, chrysanthemum 15g, mulberries 10g, rhizoma imperatae 15g, honey 15g, water lily 9g, gynostemma pentaphylla 20g, hawthorn 5-20g, fruit of Chinese wolfberry 15-20g, sucrose 5-10g.
3. the Chinese medicinal alcoholism-relieving protect liver jelly according to claim 1 or 2, it is characterised in that wherein the raw material of traditional Chinese medicine ingredients is also Including 10~15g of spina date seed.
4. Chinese medicinal alcoholism-relieving protect liver jelly according to claim 3, it is characterised in that its traditional Chinese medicine ingredients composition is for by weight Following components:Roselle 15g, dracontomelon duperreanum 10g, flower of kudzuvine 12g, olive 10g, dark plum 10g, chrysanthemum 15g, mulberries 10g, rhizoma imperatae 15g, spina date seed 10g, honey 15g, water lily 9g, gynostemma pentaphylla 20g, hawthorn 5-20g, fruit of Chinese wolfberry 15-20g, sucrose 5-10g.
5. a kind of preparation method of the Chinese medicinal alcoholism-relieving protect liver jelly based on probiotics fermention, comprises the following steps that:
(1)The chinese medicine material in addition to sucrose in formula, plus 1L water are weighed, after being cooked by slow fire 45 minutes, the dregs of a decoction is filtered off, soup is made Agent;Sucrose is added, pH to 7.0 is adjusted with NaOH;Gained mixture autoclaving 30 minutes at 115 DEG C, obtain decoction mixing Thing;
(2)With MRS culture mediums activate bifidobacterium bifidum, lactobacillus acidophilus, with LB culture mediums activate Bacillus subtillis, and with The % of percentage by volume 1% to 10 is inoculated into decoction mixture, the inoculation solution is placed in into constant-temperature table culture, and be fermented into liquid , at 25 DEG C -37 DEG C, the time is 3-4 days, is derived from target liq 500ml probiotics fermention Chinese herbal medicine groups for body, culture and fermentation Compound liquid, it is standby;
(3)Water and agar are put into pot, are heated while stir, all after dissolving, added citric acid and be allowed to dissolve;
(4)50 DEG C are cooled to, probiotics fermention herbal composite liquid is added, stirred;
(5)Add honey and hyaluronic acid is mixed thoroughly, jelly is made with Jelly machine.
6. the preparation method of the Chinese medicinal alcoholism-relieving protect liver jelly based on probiotics fermention according to claim 5, its feature exists In relieving alcoholism and protecting liver jelly is by weight composition is formulated:Probiotics fermention herbal composite liquid 10-20%, hyaluronic acid 0.5-1%, agar 0.15-0.5%, citric acid 0.15%, water adds to 100%.
CN201710161107.8A 2017-03-17 2017-03-17 A kind of Chinese medicinal alcoholism-relieving protect liver jelly and preparation method based on probiotics fermention Pending CN106901287A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN201710161107.8A CN106901287A (en) 2017-03-17 2017-03-17 A kind of Chinese medicinal alcoholism-relieving protect liver jelly and preparation method based on probiotics fermention

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN201710161107.8A CN106901287A (en) 2017-03-17 2017-03-17 A kind of Chinese medicinal alcoholism-relieving protect liver jelly and preparation method based on probiotics fermention

Publications (1)

Publication Number Publication Date
CN106901287A true CN106901287A (en) 2017-06-30

Family

ID=59187899

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201710161107.8A Pending CN106901287A (en) 2017-03-17 2017-03-17 A kind of Chinese medicinal alcoholism-relieving protect liver jelly and preparation method based on probiotics fermention

Country Status (1)

Country Link
CN (1) CN106901287A (en)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107484997A (en) * 2017-09-14 2017-12-19 柳州衍生科技有限公司 A kind of health-care fruit jelly with anti-alcohol function and preparation method thereof
CN107736594A (en) * 2017-09-14 2018-02-27 柳州衍生科技有限公司 A kind of health-care fruit jelly with Soboring-up liver-protecting function and preparation method thereof
CN110313599A (en) * 2018-03-30 2019-10-11 广州溯原生物科技有限公司 A kind of anti-trioxypurine jelly and preparation method thereof
CN115399418A (en) * 2022-08-31 2022-11-29 福建农林大学 Probiotic fermented olive juice with liver protection effect and preparation method thereof

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101292764A (en) * 2007-04-23 2008-10-29 宁小静 Sobering food
WO2012172631A1 (en) * 2011-06-13 2012-12-20 Yoshino Masaru Fermented food paste
CN102934809A (en) * 2012-12-10 2013-02-20 济南大学 Compound prepared by probiotic-fermented traditional Chinese medicine (TCM) preparation as well as preparation method and application of compound
JP2013123424A (en) * 2011-12-16 2013-06-24 Yoshio Yurugi Processed fig and method for producing the same
CN103285252A (en) * 2012-12-27 2013-09-11 福建永生活力生物工程有限公司 Oral liquid for alleviating hangover and protecting liver, and preparation method thereof
CN106036690A (en) * 2016-05-24 2016-10-26 佛山科学技术学院 Honey-vinegar-black soybean jelly and preparation method thereof

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101292764A (en) * 2007-04-23 2008-10-29 宁小静 Sobering food
WO2012172631A1 (en) * 2011-06-13 2012-12-20 Yoshino Masaru Fermented food paste
JP2013123424A (en) * 2011-12-16 2013-06-24 Yoshio Yurugi Processed fig and method for producing the same
CN102934809A (en) * 2012-12-10 2013-02-20 济南大学 Compound prepared by probiotic-fermented traditional Chinese medicine (TCM) preparation as well as preparation method and application of compound
CN103285252A (en) * 2012-12-27 2013-09-11 福建永生活力生物工程有限公司 Oral liquid for alleviating hangover and protecting liver, and preparation method thereof
CN106036690A (en) * 2016-05-24 2016-10-26 佛山科学技术学院 Honey-vinegar-black soybean jelly and preparation method thereof

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
姜锡瑞 等: "《生物发酵产业技术》", 31 May 2016, 中国轻工业出版社 *

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107484997A (en) * 2017-09-14 2017-12-19 柳州衍生科技有限公司 A kind of health-care fruit jelly with anti-alcohol function and preparation method thereof
CN107736594A (en) * 2017-09-14 2018-02-27 柳州衍生科技有限公司 A kind of health-care fruit jelly with Soboring-up liver-protecting function and preparation method thereof
CN110313599A (en) * 2018-03-30 2019-10-11 广州溯原生物科技有限公司 A kind of anti-trioxypurine jelly and preparation method thereof
CN115399418A (en) * 2022-08-31 2022-11-29 福建农林大学 Probiotic fermented olive juice with liver protection effect and preparation method thereof

Similar Documents

Publication Publication Date Title
CN102934809B (en) Composition prepared by probiotic-fermented traditional Chinese medicine (TCM) preparation as well as preparation method and application of compound
TWI500391B (en) Composition for reliving and preventing hangover and beverage comprising composition
CN107149068A (en) A kind of honey sobering-up beverage and preparation method thereof
CN106901287A (en) A kind of Chinese medicinal alcoholism-relieving protect liver jelly and preparation method based on probiotics fermention
CN104413333A (en) Ginger-flavor red date-black sugar block
CN103275844B (en) Whole-process fermenting ginger wine and preparation method thereof
CN107173656A (en) A kind of Chinese medicine fruits and vegetables probiotics fermented beverage and preparation method thereof
KR20140097961A (en) Beverage for curing of hangover
CN102696804B (en) Weight-loosing and bodybuilding traditional Chinese medicine tea
CN101085962A (en) Lophatherum gracile brongn and lalang grass wine
CN108185054A (en) A kind of lung treasured tea and preparation method thereof
CN108112717A (en) A kind of honeysuckle fire-lowering tea
CN107080136A (en) A kind of mulse and preparation method thereof
CN1200937A (en) Soboring-up liver-protecting medicine and preparation method therefor
CN112690382A (en) Beverage capable of clearing away heat and toxic materials
CN103750425B (en) Preparation method of red ginseng/fructus momordicae soup
CN102429065A (en) Method for making basil and mesona herbal tea
CN106222012A (en) A kind of fig wine alleviating rheumatism
CN106421519A (en) Health-care medical liquor
CN106309600A (en) Prescription and preparation process of de-alcoholic oral composition
CN108653476A (en) One kind is reduced internal heat anti-inflammatory, pharynx-clearing throat-benefiting Tea containing traditional Chinese medicine
CN114767826B (en) Sobering-up liver-protecting composition, beverage with sobering-up liver-protecting efficacy and preparation method thereof
CN109757573A (en) A kind of dark plum hoveniae semoveniae semen fermented tea composite beverage and preparation method thereof
CN103961627A (en) Traditional Chinese medicine sober up paste with dendrobium officinale
CN107753752A (en) A kind of relieving alcoholism and protecting liver stem of noble dendrobium electuary

Legal Events

Date Code Title Description
PB01 Publication
PB01 Publication
SE01 Entry into force of request for substantive examination
SE01 Entry into force of request for substantive examination
RJ01 Rejection of invention patent application after publication
RJ01 Rejection of invention patent application after publication

Application publication date: 20170630