CN106890277A - A kind of infantile pertussis phase chronic cough with pneumonia clearing lung and eliminating phlegm Chinese medicine preparation and preparation method thereof - Google Patents
A kind of infantile pertussis phase chronic cough with pneumonia clearing lung and eliminating phlegm Chinese medicine preparation and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a kind of infantile pertussis phase chronic cough with the clearing lung and eliminating phlegm Chinese medicine preparation and preparation method thereof of pneumonia, it is related to field of traditional Chinese.The Chinese medicine preparation, is made up of the raw material of following weight portion：16~28 parts of Centipeda minima, 10~20 parts of lankong lily bulb, 10~20 parts of earthworm, 8~16 parts of Malus spectabilis leaf, 5~15 parts of centipede, 5~10 parts of Tabasheer, 3~9 parts of the root of large-flowered skullcap, 6~12 parts of the root bark of Chinese wolf-berry, 12~18 parts of dandelion, 5~9 parts of Radix Glycyrrhizae.Reasonable recipe compatibility of the present invention, based on clearing lung and eliminating phlegm cough-relieving, supplemented by spasmolysis is relieving convulsion, has targetedly curative effect to pertussis with pneumonia.
Description
Technical field
The present invention relates to technical field of traditional Chinese medicine preparation, more particularly to a kind of infantile pertussis phase chronic cough with pneumonia clearing lung-heat
Resolving sputum Chinese medicine preparation and preparation method thereof.
Background technology
Pertussis is a kind of common Acute respiratory infectious disease caused by Bordetella pertussis of children, and its Clinical symptoms is
Paroxysmal spasmodic cough, cough end are characterized with " crow " sample roar to a high-profile, the reason for cause this sick mainly diseases caused by external factors when
Evil epidemic disease poison, and lung qi is influenceed through respiratory tract, after Bordetella pertussis invades respiratory tract, produces endotoxin, cause larynx, tracheae,
Tunica mucosa bronchiorum inflammation, a large amount of mucus of mucous membrane mucus glands secrete, its mucus sexual secretion is accumulated in trachea-bronchial epithelial cell, constantly
Stimulate nerve endings receptor in mucous membrane, form the excitement of coughing centre and produce strong continuity spasmodic cough, one hundred days
The Symptoms coughed are：In addition to pertussis general features, companion sees that cough is acute anxious, flushes red, or expectoration blood, or nasal cavity goes out
Blood, yellow tongue fur, the micro- number of veins string etc.；The course of disease is more long, can delay 2~3 months, and for infant is multiple within 5 years old, whole year can fall ill,
Winter, season in spring two are the high-incidence season, and infant's state of an illness of hypoimmunity is particularly acute, and smaller easier hair pneumonia of children age etc. is serious
Complication, this sick appeal is stronger, and malpractice is with the passing of time weak, and baby due to glottis it is narrow easily because thick secretions are stifled
Fill in and the complication such as asphyxia, cyanosis, convulsions, pneumonia, atelectasis occur, this state of an illness is obstinate, the violent spasmodic cough for causing
Easily cause a series of more serious complication such as cerebral anoxia, brain tissue damage, case fatality rate is higher.And pertussis merges pneumonia
It is most common complication, infant is common, and paroxysmal spasmodic cough is not true to type, and sputum is more.
At present, using antibiotic medicines such as ROX, azithromycins more than this disease of western medical treatment, though there is certain curative effect,
Side effect greatly, can also produce drug-resistant effect, and it is child administration to be difficult, and price is again extremely expensive, in cure rate, treatment means, controls
The aspects such as treatment expense are difficult to reach satisfied effect, although and the Chinese medicine species of existing absorbed infantile pertussis merging pneumonia is numerous
It is many, but curative effect is little, much all uses many taste traditional Chinese medicine ingredients, treatment and its adjoint Pneumonia of alleviation of infantile pertussis
The specific aim of disease is not strong, misses golden hour, delays the state of an illness.The traditional Chinese medical science thinks that the main cause of pertussis morbidity is diseases caused by external factors epidemic disease
It is malicious, interior accumulate volt phlegm caused by, and Chinese medicine preparation, Small side effects, and cheap, the traditional Chinese medical science takes clearing lung and eliminating phlegm, stopping nausea and vomiting by lowering the adverse flow of QI, town
The treatment such as Dingan County god achieves good effect, therefore a kind of both safe and effective Chinese medicine preparation of invention is significant.
The content of the invention
For above-mentioned problem, in order to overcome stage of spasmodic cough in treatment pertussis to be in the prior art difficult to alleviate and can not
The deficiency effected a permanent cure, the present invention provides a kind of clearing lung and eliminating phlegm Chinese medicine preparation of infantile pertussis phase chronic cough with pneumonia, with clearing lung-heat
Based on phlegm and relieving cough, supplemented by spasmolysis is relieving convulsion, there is targetedly curative effect with pneumonia to pertussis.
To solve the above problems, the technical solution adopted by the present invention is as follows：
A kind of infantile pertussis phase chronic cough is made up with the clearing lung and eliminating phlegm Chinese medicine preparation of pneumonia of the raw material of following weight portion：Goose
16~28 parts of grass, 10~20 parts of lankong lily bulb, 10~20 parts of earthworm, 8~16 parts of Malus spectabilis leaf, 5~15 parts of centipede, Tabasheer are not eaten
5~10 parts, 3~9 parts of the root of large-flowered skullcap, 6~12 parts of the root bark of Chinese wolf-berry, 12~18 parts of dandelion, 5~12 parts of corn stigma, 5~9 parts of Radix Glycyrrhizae.
Preferably, Chinese medicine preparation of the present invention, is made up of the raw material of following weight portion：20~25 parts of Centipeda minima, billows river hundred
Close 12~16 parts, 12~15 parts of earthworm, 10~15 parts of Malus spectabilis leaf, 8~12 parts of centipede, 6~8 parts of Tabasheer, 5~8 parts of the root of large-flowered skullcap,
8~10 parts of bone skin, 15~17 parts of dandelion, 6~10 parts of corn stigma, 6~8 parts of Radix Glycyrrhizae.
Preferably, Chinese medicine preparation of the present invention, it is characterised in that be made up of the raw material of following weight portion：22 parts of Centipeda minima,
15 parts of lankong lily bulb, 13 parts of earthworm, 12 parts of Malus spectabilis leaf, 10 parts of centipede, 7 parts of Tabasheer, 6 parts of the root of large-flowered skullcap, 9 parts of the root bark of Chinese wolf-berry, dandelion
16 parts, 8 parts of corn stigma, 7 parts of Radix Glycyrrhizae.
Further, Chinese medicine preparation of the present invention, the Chinese medicine preparation is decoction, pill, sublimed preparation, tablet, capsule, punching
Agent, granule, extract, powder, sugar coated tablet, oral liquid, honey pill agent, sublimed preparation, solution or syrup.
Wherein, infantile pertussis phase chronic cough of the present invention with the clearing lung and eliminating phlegm Chinese medicine preparation of pneumonia preparation method, including
Following steps：
（1）By said components proportioning weigh respectively Centipeda minima, lankong lily bulb, earthworm, Malus spectabilis leaf, centipede, Tabasheer, the root of large-flowered skullcap,
Each taste Chinese medicine of the root bark of Chinese wolf-berry, dandelion, corn stigma, Radix Glycyrrhizae；
（2）Centipede, the root bark of Chinese wolf-berry, Radix Glycyrrhizae are crushed respectively, frying is levigate, cross 100~150 mesh sieves, obtain fine powder a, it is standby；
（3）Centipeda minima, lankong lily bulb, Malus spectabilis leaf, corn stigma are pulverized and mixed respectively, initial 10~15 times of weight of medicinal material are added
Distilled water, soak 15~20h, backflow decoct 3~5h, filtering, add 6~8 times of distilled water of weight of initial weight, flow back
2~3h is decocted, filter residue is filtered and retain, merging filtrate is concentrated into the concentrate that 60 DEG C of relative densities are 1.15~1.20 standby；
（4）By earthworm, Tabasheer, the root of large-flowered skullcap, dandelion medicinal material, it is pulverized and mixed respectively, plus 10~concentration 70 of 12 times of weight~
90% ethanol, 10~16h of immersion, refluxing extraction 2 times, 1~2h, filters, merging filtrate every time, and vacuum distillation removes ethanol, and
It is concentrated into the concentrate that 60 DEG C of relative densities are 1.15~1.20 standby；
（5）By step（3）With（4）The concentrate of gained merges, and it is in 1.38~1.42 to continue to be concentrated into 60 DEG C of relative densities
Medicine medicinal extract, is dried under vacuum to dry extract, crushes levigate, crosses 100~150 mesh sieves, obtains fine powder b, standby；
（6）Fine powder a and fine powder b are well mixed, appropriate auxiliary material is added, using modern general Chinese medicine preparation technology, is made
The Chinese medicine finished product preparation that clinic needs.
It is further preferred that step（6）It is middle to be well mixed fine powder a and fine powder b, add appropriate superfine silica gel powder, α-gala
Sugar mixing, with ethanol as wetting agent, granulation is dried, and whole grain is encapsulated, and capsule is obtained；Or step（6）It is middle by fine powder a, step
Suddenly（3）And step（4）In concentrate mixing, add suitable amount of sucrose and preservative mixing, stir evenly, be concentrated at 60 DEG C relative
Density is 1.48~1.56, stands 20~30h, and filtration, packing obtains syrup.
Above-mentioned prescription, the drug effect of each Chinese herbal medicine is as follows：
Centipeda minima, with expelling wind and clearing away cold, wins wet, goes screen, leads to effect of nasal obstruction.Cure cold, tremble with fear and roar, larynx numbness, pertussis, eruptive disease
Stomachache, amebic dysentery, malaria, infantile malnutrition due to digestive disturbances or intestinalparasites is rushed down, nasosinusitis, nasal polyp, and mesh screen is puckery to itch, ulcer on the shank, mange, bruise.
Lankong lily bulb, for moistening the lung and relieve the cough, heat clearing and tranquillizing.Pulmonary tuberculosis is controlled, chronic cough is spitted blood, chronic bronchitis, dimly not
The disease such as sleep.
Earthworm, cold in nature, taste is salty.There is The flat liver of heat-clearing, Zhichuan dredging collateral.Return liver, stomach, lung, bladder warp.Cure mainly hyperpyrexia
Agitation, twitch, dyspnea and cough due to lung-heat, thermojunction renal shutdown, numbness pain limb fiber crops, hemiplegia, and the card such as sore swollen toxin.Cure mainly high fanatical
It is dry, convulsion, headache due to pathogenic wind-heat, hot eyes, hemiplegia etc..
Malus spectabilis leaf, has functions that clearing heat for detumescence.Control pharyngalgia, large carbuncle, traumatic injury.
Centipede, ceases wind antispastic, dispersing pathogen accumulation, the effect removed obstruction in channels to relieve pain.It is mainly used in child convulsion, tic spasm, apoplexy
The card such as mouth, hemiplegia, lockjaw, rheumatoid arthritis stubborn, sore, scrofula, venomous snake bite.It is additionally operable to treat tuberculosis on modern clinic
(tuberculous pleurisy, Tuberculous pleurisy, pulmonary tuberculosis, sporadic tuberculosis, bone tuberculosis, tuberculosis of breast and tuberculosis of cervical lymph nodes etc.),
Cancer (cancer of the esophagus, breast cancer, cutaneum carcinoma, lung cancer, the cancer of the uterus, adenocarcinoma of lip etc.).
Tabasheer, is called tabasheer, henon bamboo Huang, bamboo pseudo-ginseng, XUESANQI, bamboo ginseng, red dumpling, the red dumpling of bamboo, the red plaque of bamboo, light
Chrysanthemum, nandina, henon bamboo, bamboo, bamboo cocoon；Tabasheer has functions that preventing phlegm from forming and stopping coughing, promoting blood circulation by removing wind, dampness removing；Cure mainly cough phlegm
Many, pertussis, under band, stomachache, arthralgia pain due to rheumatism, child convulsion, traumatic injury.
The root of large-flowered skullcap, with heat-clearing and damp-drying drug, cool blood is antiabortive, detoxicating functions.Cure mainly warm heat disease, the infection of the upper respiratory tract, cough with lung heat,
The diseases such as neonatal jaundice caused by dampness-heat, pneumonia, dysentery, hemoptysis, hot eyes, fetal irritability, hypertension, carbuncle swells furuncle sore.
The root bark of Chinese wolf-berry, alias Chinese wolfberry skin, with cool blood except steaming, clearing lung-heat fall fire effect.Consumptive disease hectic fever night sweat is controlled, lung heat cough and asthma is spitted blood,
Bleeding from five sense organs or subcutaneous tissue, blood strangury is quenched one's thirst, hypertension, carbuncle swells, dislikes sore.
Dandelion, flat property and sweet taste slight bitter.With clearing heat and detoxicating, effect of dispersing swelling and dissipating binds.There is significant galgctogogue action, treat
Mastitis is largely effective.No matter decoct juice oral, still smash mud external application, all there is effect.Additionally, dandelion also has diuresis, laxative, moves back
Jaundice, cholagogic, aid digestion, increasing appetite, treat gastric and duodenal ulcer, can also prevent for cancer, stomach cancer, the cancer of the esophagus and various cancers
The effects such as.
Corn stigma, mild-natured, slightly sweet flavor is nontoxic.Enter liver, kidney, bladder warp.Diuresis, expels the heat-evil, soothing the liver, cholagogic.Control ephritis water
It is swollen, tinea pedis, icterohepatitis, hypertension, cholecystitis, gall stone, diabetes, hematemesis and epistaxis, nasosinusitis, acute mastitis.
Radix Glycyrrhizae：It is mild-natured, sweet, return 12 warps.There are removing toxic substances, eliminating the phlegm, analgesic, spasmolysis so that the pharmacological action such as anticancer.In
On doctor, Radix Glycyrrhizae is invigorated the spleen and benefited qi, and moistening lung, emergency removing toxic substances, hundred medicines of mediation are coughed in taste.Licorice is with curing mainly abscess of throat, pain subcutaneous ulcer sore, stomach
Enteron aisle ulcer and antidote poison, food poisoning etc..
In sum, the beneficial effects of the invention are as follows：
1st, we merge symptoms of pneumonia according to Traditional Chinese medical theory for pertussis, and Centipeda minima is good at expelling wind and clearing away cold and leads in side
Nasal obstruction, centipede is longer than ceases wind antispastic, and dispersing pathogen accumulation, the effect removed obstruction in channels to relieve pain, property is apt to walk to alter, and the effect of expelling endogenous wind to relieve convulsion is rather strong,
And property is strong with sudden force, it is good at removing toxic substances, Centipeda minima is associated with centipede, the child convulsion, hyperpyrexia for pertussis appearance are irritated, convulsion is fainted
The diseases such as tic；Shared with lankong lily bulb, Tabasheer, dandelion and corn stigma, with clearing lung-heat heat, soothing the liver diuresis, preventing phlegm from forming and stopping coughing
Effect, for symptoms such as infection of the upper respiratory tract pneumonia abundant expectoration, cough with lung heat, then with earthworm, Malus spectabilis leaf, the root of large-flowered skullcap, root bark of Chinese wolf-berry compatibility,
With heat-clearing and fire-reducing, dredging collateral of relievining asthma, cool blood relieving restlessness, effect of dispersing swelling and dissipating binds are sweet for symptoms such as hyperpyrexia agitation, arthralgia pain due to rheumatism
Grass is invigorated the spleen and benefited qi, and moistening lung, emergency removing toxic substances, hundred medicines of mediation, energy clearing lung-heat heat, preventing phlegm from forming and stopping coughing, infantile pertussis chronic cough of releiving are coughed in taste
Various symptoms, and merge pneumonia for pertussis, based on clearing lung and eliminating phlegm cough-relieving, supplemented by spasmolysis is relieving convulsion, to pertussis with lung
Inflammation has targetedly curative effect.
2nd, preparation method of the present invention is simple, and effect is substantially, and security is good, applied widely, each bulk drug in we
It is food or medicine-food two-purpose food materials, wide material sources, healthy, green, safety has no toxic side effect to human body.
Specific embodiment
A kind of infantile pertussis phase chronic cough with pneumonia clearing lung and eliminating phlegm Chinese medicine preparation, by the raw material system of following weight portion
Into：16~28 parts of Centipeda minima, 10~20 parts of lankong lily bulb, 10~20 parts of earthworm, 8~16 parts of Malus spectabilis leaf, 5~15 parts of centipede,
5~10 parts of Tabasheer, 3~9 parts of the root of large-flowered skullcap, 6~12 parts of the root bark of Chinese wolf-berry, 12~18 parts of dandelion, 5~12 parts of corn stigma, Radix Glycyrrhizae 5~9
Part.
Used as the preferred embodiment for the present invention, Chinese medicine preparation of the present invention is made up of the raw material of following weight portion：Centipeda minima
20~25 parts, 12~16 parts of lankong lily bulb, 12~15 parts of earthworm, 10~15 parts of Malus spectabilis leaf, 8~12 parts of centipede, Tabasheer 6~8
Part, 5~8 parts of the root of large-flowered skullcap, 8~10 parts of the root bark of Chinese wolf-berry, 15~17 parts of dandelion, 6~10 parts of corn stigma, 6~8 parts of Radix Glycyrrhizae.
As the preferred embodiment for the present invention, Chinese medicine preparation of the present invention, it is characterised in that by the raw material system of following weight portion
Into：22 parts of Centipeda minima, 15 parts of lankong lily bulb, 13 parts of earthworm, 12 parts of Malus spectabilis leaf, 10 parts of centipede, 7 parts of Tabasheer, 6 parts of the root of large-flowered skullcap,
9 parts of the root bark of Chinese wolf-berry, 16 parts of dandelion, 8 parts of corn stigma, 7 parts of Radix Glycyrrhizae.
Further, Chinese medicine preparation of the present invention, the Chinese medicine preparation is decoction, pill, sublimed preparation, tablet, capsule, punching
Agent, granule, extract, powder, sugar coated tablet, oral liquid, honey pill agent, sublimed preparation, solution or syrup.
Wherein, infantile pertussis phase chronic cough of the present invention with the clearing lung and eliminating phlegm Chinese medicine preparation of pneumonia preparation method, including
Following steps：
（1）By said components proportioning weigh respectively Centipeda minima, lankong lily bulb, earthworm, Malus spectabilis leaf, centipede, Tabasheer, the root of large-flowered skullcap,
Each taste Chinese medicine of the root bark of Chinese wolf-berry, dandelion, corn stigma, Radix Glycyrrhizae；
（3）Centipede, the root bark of Chinese wolf-berry, Radix Glycyrrhizae are crushed respectively, frying is levigate, cross 100~150 mesh sieves, obtain fine powder a, it is standby；
（3）Centipeda minima, lankong lily bulb, Malus spectabilis leaf, corn stigma are pulverized and mixed respectively, initial 10~15 times of weight of medicinal material are added
Distilled water, soak 15~20h, backflow decoct 3~5h, filtering, add 6~8 times of distilled water of weight of initial weight, flow back
2~3h is decocted, filter residue is filtered and retain, merging filtrate is concentrated into the concentrate that 60 DEG C of relative densities are 1.15~1.20 standby；
（4）By earthworm, Tabasheer, the root of large-flowered skullcap, dandelion medicinal material, it is pulverized and mixed respectively, plus 10~concentration 70 of 12 times of weight~
90% ethanol, 10~16h of immersion, refluxing extraction 2 times, 1~2h, filters, merging filtrate every time, and vacuum distillation removes ethanol, and
It is concentrated into the concentrate that 60 DEG C of relative densities are 1 .15~1 .20 standby；
（5）By step（3）With（4）The concentrate of gained merges, and it is in 1.38~1.42 to continue to be concentrated into 60 DEG C of relative densities
Medicine medicinal extract, is dried under vacuum to dry extract, crushes levigate, crosses 100~150 mesh sieves, obtains fine powder b, standby；
（6）Fine powder a and fine powder b are well mixed, appropriate auxiliary material is added, using modern general Chinese medicine preparation technology, is made
The Chinese medicine finished product preparation that clinic needs.
As the preferred embodiment for the present invention, step（6）It is middle to be well mixed fine powder a and fine powder b, add appropriate micro mist silicon
Glue, α-galactolipin mixing, with ethanol as wetting agent, granulation is dried, and whole grain is encapsulated, and capsule is obtained；Or step（6）It is middle to incite somebody to action
Fine powder a, step（3）And step（4）In concentrate mixing, add suitable amount of sucrose and preservative mixing, stir evenly, it is dense at 60 DEG C
It is 1.48~1.56 to be reduced to relative density, stands 20~30h, and filtration, packing obtains syrup.
The present invention is described in further detail with reference to embodiment：
Embodiment 1
Infantile pertussis phase chronic cough with the clearing lung and eliminating phlegm of pneumonia syrup prescription：22 parts of Centipeda minima, 15 parts of lankong lily bulb,
13 parts of earthworm, 12 parts of Malus spectabilis leaf, 10 parts of centipede, 7 parts of Tabasheer, 6 parts of the root of large-flowered skullcap, 9 parts of the root bark of Chinese wolf-berry, 16 parts of dandelion, corn stigma 8
Part, 7 parts of Radix Glycyrrhizae.
Wherein, infantile pertussis phase chronic cough of the present invention with the clearing lung and eliminating phlegm Chinese medicine preparation of pneumonia preparation method, including
Following steps：
（1）By said components proportioning weigh respectively Centipeda minima, lankong lily bulb, earthworm, Malus spectabilis leaf, centipede, Tabasheer, the root of large-flowered skullcap,
Each taste Chinese medicine of the root bark of Chinese wolf-berry, dandelion, corn stigma, Radix Glycyrrhizae；
（2）Centipede, the root bark of Chinese wolf-berry, Radix Glycyrrhizae are crushed respectively, frying is levigate, cross 120 mesh sieves, obtain fine powder a, it is standby；
（3）Centipeda minima, lankong lily bulb, Malus spectabilis leaf, corn stigma are pulverized and mixed respectively, initial 12 times of steamings of weight of medicinal material are added
Distilled water, soaks 18h, and backflow decocts 4h, and filtering adds 7 times of distilled water of weight of initial weight, and backflow decocts 2.5h, filtering
And retaining filter residue, merging filtrate is concentrated into the concentrate that 60 DEG C of relative densities are 1.15 standby；
（4）By earthworm, Tabasheer, the root of large-flowered skullcap, dandelion medicinal material, it is pulverized and mixed respectively, plus 12 times of ethanol of the concentration of weight 80%,
Immersion 12h, refluxing extraction 2 times, each 1.5h, filtering, merging filtrate, vacuum distillation removes ethanol, and is concentrated into 60 DEG C relatively
Density be 1.15 concentrate it is standby；
（5）By fine powder a, step（3）And step（4）In concentrate mixing, add suitable amount of sucrose and preservative mixing, stir evenly,
It is 1.48 that relative density is concentrated at 60 DEG C, stands 25h, and filtration, packing obtains syrup.
Embodiment 2
Infantile pertussis phase chronic cough with the clearing lung and eliminating phlegm of pneumonia syrup prescription：25 parts of Centipeda minima, 16 parts of lankong lily bulb,
15 parts of earthworm, 15 parts of Malus spectabilis leaf, 8 parts of centipede, 6 parts of Tabasheer, 5 parts of the root of large-flowered skullcap, 8 parts of the root bark of Chinese wolf-berry, 17 parts of dandelion, corn stigma 10
Part, 8 parts of Radix Glycyrrhizae.
Wherein, infantile pertussis phase chronic cough of the present invention with the clearing lung and eliminating phlegm Chinese medicine preparation of pneumonia preparation method, including
Following steps：
（1）By said components proportioning weigh respectively Centipeda minima, lankong lily bulb, earthworm, Malus spectabilis leaf, centipede, Tabasheer, the root of large-flowered skullcap,
Each taste Chinese medicine of the root bark of Chinese wolf-berry, dandelion, corn stigma, Radix Glycyrrhizae；
（2）Centipede, the root bark of Chinese wolf-berry, Radix Glycyrrhizae are crushed respectively, frying is levigate, cross 150 mesh sieves, obtain fine powder a, it is standby；
（3）Centipeda minima, lankong lily bulb, Malus spectabilis leaf, corn stigma are pulverized and mixed respectively, initial 15 times of steamings of weight of medicinal material are added
Distilled water, soaks 20h, and backflow decocts 5h, and filtering adds 8 times of distilled water of weight of initial weight, and backflow decocts 3h, and filtering is simultaneously
Retain filter residue, merging filtrate is concentrated into the concentrate that 60 DEG C of relative densities are 1.20 standby；
（4）By earthworm, Tabasheer, the root of large-flowered skullcap, dandelion medicinal material, it is pulverized and mixed respectively, plus 12 times of ethanol of the concentration of weight 90%,
Immersion 16h, refluxing extraction 2 times, each 2h, filtering, merging filtrate, vacuum distillation remove ethanol, and be concentrated into 60 DEG C it is relatively close
Spend for 1.20 concentrate is standby；
（5）By step（3）With（4）The concentrate of gained merges, and continues to be concentrated into the Chinese medical concrete that 60 DEG C of relative densities are 1.42,
It is dried under vacuum to dry extract, crushes levigate, cross 150 mesh sieves, obtains fine powder b, it is standby；
（6）Fine powder a and fine powder b are well mixed, appropriate superfine silica gel powder, α-galactolipin mixing, with ethanol as wetting agent, system is added
Grain, dries, and whole grain is encapsulated, and capsule is obtained.
Embodiment 3
Infantile pertussis phase chronic cough with the clearing lung and eliminating phlegm of pneumonia powder prescription：20 parts of Centipeda minima, 12 parts of lankong lily bulb,
Dragon 12 parts, 10 parts of Malus spectabilis leaf, 12 parts of centipede, 8 parts of Tabasheer, 8 parts of the root of large-flowered skullcap, 10 parts of the root bark of Chinese wolf-berry, 15 parts of dandelion, 6 parts of corn stigma,
6 parts of Radix Glycyrrhizae.
Wherein, infantile pertussis phase chronic cough of the present invention with the clearing lung and eliminating phlegm Chinese medicine preparation of pneumonia preparation method, including
Following steps：
（1）By said components proportioning weigh respectively Centipeda minima, lankong lily bulb, earthworm, Malus spectabilis leaf, centipede, Tabasheer, the root of large-flowered skullcap,
Each taste Chinese medicine of the root bark of Chinese wolf-berry, dandelion, corn stigma, Radix Glycyrrhizae；
（2）Centipede, the root bark of Chinese wolf-berry, Radix Glycyrrhizae are crushed respectively, frying is levigate, cross 100 mesh sieves, obtain fine powder a, it is standby；
（3）Centipeda minima, lankong lily bulb, Malus spectabilis leaf, corn stigma are pulverized and mixed respectively, initial 10 times of steamings of weight of medicinal material are added
Distilled water, soaks 15h, and backflow decocts 3h, and filtering adds 6 times of distilled water of weight of initial weight, and backflow decocts 2h, and filtering is simultaneously
Retain filter residue, merging filtrate is concentrated into the concentrate that 60 DEG C of relative densities are 1.15 standby；
（4）By earthworm, Tabasheer, the root of large-flowered skullcap, dandelion medicinal material, it is pulverized and mixed respectively, plus 10 times of ethanol of the concentration of weight 70%,
Immersion 10h, refluxing extraction 2 times, each 1h, filtering, merging filtrate, vacuum distillation remove ethanol, and be concentrated into 60 DEG C it is relatively close
Spend for 1.15 concentrate is standby；
（5）By step（3）With（4）The concentrate of gained merges, and continues to be concentrated into the Chinese medical concrete that 60 DEG C of relative densities are 1.38,
It is dried under vacuum to dry extract, crushes levigate, cross 100 mesh sieves, obtains fine powder b, it is standby；
（6）Fine powder a and fine powder b are well mixed, are sterilized, packing is obtained powder.
Embodiment 4
Infantile pertussis phase chronic cough with the clearing lung and eliminating phlegm of pneumonia tablet prescription：28 parts of Centipeda minima, 20 parts of lankong lily bulb,
Dragon 20 parts, 16 parts of Malus spectabilis leaf, 15 parts of centipede, 10 parts of Tabasheer, 3 parts of the root of large-flowered skullcap, 6 parts of the root bark of Chinese wolf-berry, 12 parts of dandelion, 5 parts of corn stigma,
5 parts of Radix Glycyrrhizae.Except step in preparation method（6）Difference, other steps of preparation method are identical with embodiment 1~3.
Embodiment 5
Infantile pertussis phase chronic cough with the clearing lung and eliminating phlegm of pneumonia pill prescription：16 parts of Centipeda minima, 10 parts of lankong lily bulb,
Dragon 10 parts, 8 parts of Malus spectabilis leaf, 5 parts of centipede, 5 parts of Tabasheer, 9 parts of the root of large-flowered skullcap, 12 parts of the root bark of Chinese wolf-berry, 18 parts of dandelion, 12 parts of corn stigma,
9 parts of Radix Glycyrrhizae.Except step in preparation method（6）Difference, other steps of preparation method are identical with embodiment 1~3.
Make further checking to Chinese medicine preparation of the present invention below by experiment：
First, long term toxicity test：
Experimental animal SD rats are provided by Nanning City experimental animal and animal experimental center.Give various concentrations (38.5,12.3,
3.6g crude drugs/kg) Chinese medicine preparation of the invention, daily gavage once, continuous 90 days, lived and kill after last dose by 24 hours each groups
1/2 animal (male and female half and half), work is killed after remaining 1/2 animal continues to observe 2 weeks.Outward appearance, the general row of animal are observed during experiment
For, food ration, changes of weight, after administration 90 days and be discontinued carry out within 2 weeks hematology (RBC, HB, granulophilocyte, PLT, CT, WBC
And classification) and blood biochemical (AST, ALT, ALP, Glu, BUN, Crea, TP, T .BIL, ALB, CHOL), urine biochemistry, internal organs
The index checkings such as coefficient, Histopathology.Result of the test shows：Chinese medicine preparation of the invention is in high, medium and low dosage group animal one
As in good condition, appearance sign, behavioral activity, food-intake and body weight increase change without exception；Three dosage groups and control group
Hematological examination, blood biochemical analysis, urine biochemical analysis are between normal range (NR), group without significant difference；Each group main organs group
Pathological examination is knitted to show no obvious abnormalities.These parameters also have no change after being discontinued 2 weeks.This experiment dosage is respectively clinic
385,123,36 times of dosage, according to result of the test Chinese medicine preparation of the invention high, medium and low three dosage (38.5,
12.3rd, 3.6g crude drugs/kg) continuous 90 days administration rat is had no significant effect, it is extensive without clear and definite toxicity target organ and sensitive indicator
Multiple phase observation also has no retardance toxic reaction, points out the dose safety of Chinese medicine preparation clinical practice of the invention higher.
2nd, clinical trial
1st, treatment target：, simultaneously with pneumonia, minimum 30d is maximum 9 years old, average age 12 months for 86 pertussis infants.
2nd, drug usage consumption
Syrup is prepared using embodiment 1 to above-mentioned infant, three times a day, each 15g, equal one after each meal, medication period
Between disable antibiotic.
3rd, treatment results
After infant is taken medicine 1~3 week, clinical sign, paroxysmal spasmodic cough abundant expectoration and chicken crow the sound person of being wholly absent 82, and 4 invalid, and effective percentage reaches
95.3%.In healing case totally 48 within course for the treatment of 7d, totally 25 in 8~14d, 15~21d person totally 9.
Model case：Soup, female, 4 years old.Infant in being generated heat before 2 weeks, cough, 37.2 DEG C of body temperature, hospital treatment by runny nose
After 4d, body temperature is normal, but cough does not subtract, and increasingly aggravates, each continuous more than ten sound, particularly severe at nightfall in paroxysmal, abundant expectoration
And it is sticky, audible chicken crows sound when cough stops.Physical examination：Eye conjunctiva selects, and two eyelids slightly edema is flushed red when coughing, dehisced
Loll, both hands are clenched fist, tears and viscous phlegm are exchanged, red tongue with yellowish fur, the double pulmonary respiration sounds of auscultation are coarse.Surrounding hemogram, total white blood cells
15*109/ L, neutral 34%, lymph 76% is diagnosed as pertussis.The syrup for giving the preparation of embodiment 1 is taken, and paroxysmal spasmodic cough is bright after 2 days
It is aobvious to take a turn for the better, then dense phlegm reduction in 3 days is taken, fully recovered by continuing to take 2.Continue to take 3 to consolidate curative effect, follow-up January was not
Recurrence.
Claims (6)
1. a kind of infantile pertussis phase chronic cough with pneumonia clearing lung and eliminating phlegm Chinese medicine preparation, it is characterised in that by following weight portion
Raw material is made：16~28 parts of Centipeda minima, 10~20 parts of lankong lily bulb, 10~20 parts of earthworm, 8~16 parts of Malus spectabilis leaf, centipede 5~
15 parts, 5~10 parts of Tabasheer, 3~9 parts of the root of large-flowered skullcap, 6~12 parts of the root bark of Chinese wolf-berry, 12~18 parts of dandelion, 5~12 parts of corn stigma, Radix Glycyrrhizae
5~9 parts.
2. a kind of infantile pertussis phase chronic cough according to claim 1 with pneumonia clearing lung and eliminating phlegm Chinese medicine preparation, it is special
Levy is to be made up of the raw material of following weight portion：20~25 parts of Centipeda minima, 12~16 parts of lankong lily bulb, 12~15 parts of earthworm,
10~15 parts of Malus spectabilis leaf, 8~12 parts of centipede, 6~8 parts of Tabasheer, 5~8 parts of the root of large-flowered skullcap, 8~10 parts of the root bark of Chinese wolf-berry, dandelion 15~17
Part, 6~10 parts of corn stigma, 6~8 parts of Radix Glycyrrhizae.
3. a kind of infantile pertussis phase chronic cough according to claim 1 with pneumonia clearing lung and eliminating phlegm Chinese medicine preparation, it is special
Levy is to be made up of the raw material of following weight portion：22 parts of Centipeda minima, 15 parts of lankong lily bulb, 13 parts of earthworm, 12 parts of Malus spectabilis leaf, Wu
10 parts of centipede, 7 parts of Tabasheer, 6 parts of the root of large-flowered skullcap, 9 parts of the root bark of Chinese wolf-berry, 16 parts of dandelion, 8 parts of corn stigma, 7 parts of Radix Glycyrrhizae.
4. a kind of infantile pertussis phase chronic cough as described in claim 1-3 is any with pneumonia clearing lung and eliminating phlegm Chinese medicine preparation,
It is characterized in that：The Chinese medicine preparation be decoction, pill, sublimed preparation, tablet, capsule, electuary, granule, extract, powder,
Sugar coated tablet, oral liquid, honey pill agent, sublimed preparation, solution or syrup.
5. any one the infantile pertussis phase chronic cough according to claim 1-3 with pneumonia clearing lung and eliminating phlegm Chinese medicine system
The preparation method of agent, it is characterised in that comprise the following steps：
（1）By said components proportioning weigh respectively Centipeda minima, lankong lily bulb, earthworm, Malus spectabilis leaf, centipede, Tabasheer, the root of large-flowered skullcap,
Each taste Chinese medicine of the root bark of Chinese wolf-berry, dandelion, corn stigma, Radix Glycyrrhizae；
Centipede, the root bark of Chinese wolf-berry, Radix Glycyrrhizae are crushed respectively, frying is levigate, cross 100~150 mesh sieves, obtain fine powder a, it is standby；
（3）Centipeda minima, lankong lily bulb, Malus spectabilis leaf, corn stigma are pulverized and mixed respectively, initial 10~15 times of weight of medicinal material are added
Distilled water, soak 15~20h, backflow decoct 3~5h, filtering, add 6~8 times of distilled water of weight of initial weight, flow back
2~3h is decocted, filter residue is filtered and retain, merging filtrate is concentrated into the concentrate that 60 DEG C of relative densities are 1.15~1.20 standby；
（4）By earthworm, Tabasheer, the root of large-flowered skullcap, dandelion medicinal material, it is pulverized and mixed respectively, plus 10~concentration 70 of 12 times of weight~
90% ethanol, 10~16h of immersion, refluxing extraction 2 times, 1~2h, filters, merging filtrate every time, and vacuum distillation removes ethanol, and
It is concentrated into the concentrate that 60 DEG C of relative densities are 1.15~1.20 standby；
（5）By step（3）With（4）The concentrate of gained merges, and it is in 1.38~1.42 to continue to be concentrated into 60 DEG C of relative densities
Medicine medicinal extract, is dried under vacuum to dry extract, crushes levigate, crosses 100~150 mesh sieves, obtains fine powder b, standby；
（6）Fine powder a and fine powder b are well mixed, appropriate auxiliary material is added, using modern general Chinese medicine preparation technology, is made
The Chinese medicine finished product preparation that clinic needs.
6. a kind of infantile pertussis phase chronic cough according to claim 5 with the clearing lung and eliminating phlegm Chinese medicine preparation of pneumonia system
Preparation Method, it is characterised in that：Step（6）It is middle to be well mixed fine powder a and fine powder b, add appropriate superfine silica gel powder, α-galactolipin to mix
Close, with ethanol as wetting agent, granulation is dried, and whole grain is encapsulated, and capsule is obtained；Or step（6）It is middle by fine powder a, step（3）
And step（4）In concentrate mixing, add suitable amount of sucrose and preservative mixing, stir evenly, be concentrated into relative density at 60 DEG C
It is 1.48~1.56, stands 20~30h, filtration, packing obtains syrup.
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