CN106798701A - 一种用于防治皮肤瘙痒的中药沐浴露及其制备方法 - Google Patents
一种用于防治皮肤瘙痒的中药沐浴露及其制备方法 Download PDFInfo
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- CN106798701A CN106798701A CN201710157877.5A CN201710157877A CN106798701A CN 106798701 A CN106798701 A CN 106798701A CN 201710157877 A CN201710157877 A CN 201710157877A CN 106798701 A CN106798701 A CN 106798701A
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Abstract
本发明具体涉及一种用于防治皮肤瘙痒的中药沐浴露，属于日常清洁护理用品领域，为解决肌肤瘙痒人群的问题、同时避免更多的人群出现此困扰，本发明提供一种用于防治皮肤瘙痒的中药沐浴露，本发明的用于防治皮肤瘙痒的中药沐浴露是由以下重量份数的组分为原料混配制成的：中药提取液30‑50份，乳化增溶剂3‑8份，植物源表面活性剂10‑16份，氯化钠0.6‑1.0份，柠檬酸0.02‑0.08份，防腐剂0.1‑0.3份，植物香精0.2‑0.6份，纯化水30‑50份；所述的中药提取液是由以下中药原料：板蓝根，薄荷，苦参，紫苏，黄柏，蛇床子，地肤子，金银花，本发明可广泛应用到日常清洁护理领域中。
Description
技术领域
本发明具体涉及一种用于防治皮肤瘙痒的中药沐浴露，属于日常清洁护理用品领域。
背景技术
沐浴露是现代人洗澡时必不可少的清洁护理用品，市场上沐浴露的种类繁多，但以中药为主要成分，能起到防治诸如皮癣、湿疹等引起的皮肤瘙痒等肌肤不适的沐浴露却很少。目前市售的沐浴露大多是仅有清洁去污作用的日常清洁用品，这类沐浴露主要用具有价格低廉、高起泡、强去污性能的阴离子表面活性剂制备而成，存在破坏皮脂膜、破坏肌肤微环境等隐患。
皮肤病理(如皮肤瘙痒、皮癣、湿疹等)状态下的表皮已损伤、皮肤微环境已经失衡，因而，很多患者在就医时会被医生告知“不要用香皂、沐浴露洗澡”，因为，此时使用那些常规沐浴产品，只会引起更严重的瘙痒问题。
发明内容
为解决肌肤瘙痒人群的问题、同时避免更多的人群出现此困扰，本发明提供一种用于防治皮肤瘙痒的中药沐浴露。
该发明使用多味具有抗菌、抗病毒、润肤止痒、调理肌肤微环境等功效的皮肤科外用中药，抗菌抗病毒的同时，能很好的缓解、防治各种皮肤问题，防止皮肤进一步损伤，并具有一定的治疗作用，健康皮肤亦可安全使用。
本发明的用于防治皮肤瘙痒的中药沐浴露是由以下重量份数的组分为原料混配制成的：
所述的中药提取液是由以下重量份数的中药原料：
一种用于防治皮肤瘙痒的中药沐浴露，所述各组分的较佳重量份数为：
所述的中药提取液包括以下重量份的中药原料：
所述的植物源表面活性剂是由椰油酰胺丙基甜菜碱、烷基糖苷、甜菜碱、椰油酰胺中的一种或几种的混合物。
所述的乳化增溶剂是由聚氧乙烯脱水山梨醇单油酸酯、氢化蓖麻油、辛普高效增溶剂中的一种或几种的混合物。
所述的防腐剂是由谷物发酵产物—A.SAP抗菌剂、植物防腐—萝卜根发酵产物、氯化十六烷基吡啶中的一种或几种的混合物。
所述的中药沐浴露的pH为5.0-7.0。
一种制备用于防治皮肤瘙痒的中药沐浴露的方法，是将板蓝根、薄荷、苦参、紫苏、黄柏、蛇床子、地肤子和金银花按照所述重量份数混合，以水为溶剂进行提取，并在提取液中调配所述重量份数的植物源表面活性剂、乳化增溶剂、植物香精、柠檬酸、防腐剂和氯化钠后灌装制成。
一种用于防治皮肤瘙痒的中药沐浴露的制备方法，包括以下先后顺序制备步骤：
原料预处理步骤：将板蓝根、薄荷、苦参、紫苏、黄柏、蛇床子、地肤子和金银花八味中药进行精选，清洗，烘干备用；
第一次煎煮步骤：将预处理后的原料按所述重量份数称重混合，置于煎煮锅中，加入8-12倍量纯化水，浸泡30分钟。加热沸腾后保持微沸状态煎煮60分钟，200目筛过滤，滤液存于储液罐中；
第二次煎煮步骤：药渣倒回煎煮锅中，加入6-8倍量纯化水进行第二次煎煮，加热沸腾后保持微沸状态煎煮60分钟，200目筛过滤，滤液存于储液罐中；
混合浓缩步骤：将第一次煎煮步和第二次煎煮步骤所得的药液合并，于煎煮锅中减压真空浓缩至1.10±0.02g/ml(65±2℃下测定)，200目筛过滤得中药浓缩液；
再将中药浓缩液于0-4℃的低温冷库中储存，常温下，提取的中药提取液中有效成分以大分子形式存在极不稳定，而在0-4℃的低温下保存可最大程度保持有效成分含量，提升产品功效。使用时再用纯化水稀释10倍，并经200目滤布过滤后，得中药提取液投料；
调配步骤：在所述重量份数的纯化水中加入所述重量份数的乳化增溶剂、植物源表面活性剂充分搅拌均匀；用所述重量份数的柠檬酸调pH值至5.0-7.0，缓慢加入所述重量份数的中药提取液，充分搅拌混匀；将所述重量份数的防腐剂、植物香精依次加入调配罐中，充分搅拌混匀；将所述重量份数的氯化钠缓慢撒入调配罐中，充分搅拌均匀，用200目滤布充分过滤；
灌装步骤：经检验合格后进行灌装。
本发明中的苦参，清热燥湿、祛风杀虫，疗皮肤之瘙痒。煎剂在试管中，高浓度(1：100)对结核杆菌有抑制作用。煎剂(8％)、水浸剂(1：3)在体外对某些常见的皮肤真菌有不同程度的抑制作用。
本发明中的紫苏，外开皮毛，散邪而解表。《履巉岩本草》记载"止金疮出血；疗痔疾，煎汤洗之。"紫苏叶在试管内能抑制葡萄球菌的生长。
本发明中的黄柏，清热燥湿，泻火除蒸，解毒疗疮。用治湿热疮疡、湿疹之症，既可内服，又可外用。黄柏抗菌有效成分为小檗碱，体外试验对金黄色葡萄球菌、肺炎球菌、白喉杆菌、草绿色链球菌、痢疾杆菌(宋内氏除外)等均有效；在试管中，黄柏煎剂或浸剂对若干常见的致病性真菌有不同程度的抑菌作用，其水煎剂还能杀死钩端螺旋体。
本发明中的蛇床子，辛、苦，温；解毒杀虫燥湿祛风。外治外阴湿疹，湿疹疥癣；寒湿带下；湿痹腰痛。是中医皮肤科外用药物中常用的一味中药，在临床治疗过程中，发现其止痒效果特别好，在中药悠久的历史中，它活跃于皮肤病的治疗方剂中，被誉为“皮肤科的止痒剂”。
本发明中的地肤子，清热利湿，祛风止痒。用于小便涩痛，阴痒带下，风疹，湿疹，皮肤瘙痒。《别录》中记载："去皮肤中热气，散恶疮，疝瘕，强阴，使人润泽。"其水浸剂(1：3)在试管内对许兰氏黄癣菌，奥杜盎氏小芽胞癣菌等皮肤真菌有抑制作用。
本发明中的板蓝根，具解毒功效，《分类草药性》中记载：解诸毒恶疮，散毒去火，捣汁或服或涂。抗菌抗病毒作用极佳，其水浸液对枯草杆菌、金黄色葡萄球菌，八联球菌、大肠杆菌、伤寒杆菌、副伤寒甲杆菌、痢疾(志贺氏、弗氏)杆菌、肠炎杆菌等都有抑制作用。
本发明中的薄荷，宣散风热，清头目，透疹。用于风温初起，口疮、风疹、麻疹。薄荷中的薄荷醇局部应用可治头痛、神经痛、瘙痒等。抗病毒作用--薄荷水煎剂1：20浓度，对病毒ECHO11株有抑制作用。镇痛、止痒作用--薄荷脑主要作外用止痒、微弱的局麻及对抗刺激剂，涂于局部由于刺激神经而引起凉感，并抑制痛觉神经。杀菌作用--薄荷脑有很强的杀菌作用，d-薄荷脑比L-薄荷脑的抑菌作用强。
本发明中的金银花，清热解毒作用极佳，在外科中为常用之品，一般用于有红肿热痛的疮痈肿毒，用新鲜者捣烂外敷。金银花抗菌作用极佳，在体外对多种细菌：如伤寒杆菌、副伤寒杆菌、大肠杆菌、变形杆菌、绿脓杆菌、百日咳杆菌，霍乱弧菌以及葡萄球菌、链球菌、肺炎双球菌、脑膜炎球菌等，均有抑制作用；金银花提取液对金黄色葡萄球菌有效；对慢性气管炎中某些常见细菌：如肺炎球菌、甲型链球菌、卡他球菌；也有抑菌作用(平板法)。
复方中药中苦参、黄柏、地肤子、板蓝根、金银花等，苦寒，行清热解毒、泻火燥湿之效；辅以紫苏、蛇床子，辛温，行气散寒、祛风解表；薄荷，辛凉，宣散风热，除秽透疹。诸药配伍，对无论寒、热、湿毒淤积引起的肌肤疾患，均有良好的功效，且具有协同增效作用。而从现代药理研究方面分析：此配方中，板蓝根抗病毒；苦参破坏细菌细胞壁和细胞膜结构；黄柏抑制细菌DNA复制；地肤子可以使真菌菌丝体粘连，细胞壁破损，最终菌丝断裂；金银花通过抑制单核巨噬细胞的活化和分化，并抑制炎症介质生成，起到抑制炎症反应效果；蛇床子通过影响组织胺释放及拮抗Schultz-Dzle反应，起到优秀的抗过敏作用；薄荷中的薄荷脑和薄荷醇可以通过改变皮肤角质层细胞的排列，来促进药物有效成分更快的通过皮肤屏障进入真皮层，解决肌肤问题；这样配伍使用，理论上对于病菌的抑制和杀灭作用，以及抗炎抗过敏方面具有协同增效作用。
在实验室体外抑菌率测定实验中，此复方中药经煎煮提取、浓缩得到的提取液的抑菌效果显著优于这些中药单独提取、浓缩后，再把提取液进行简单混合的抑菌效果。说明，此复方中药的配伍在抑菌性能方面具有良好的协同增效作用。
本发明中的复方中药，采用现代制药工艺萃取有效成分，使得本发明的用于防治皮肤瘙痒的中药沐浴露具有良好的抑菌抗病毒、润肤去燥、祛湿止痒效果，缓解各种肌肤不适，安全温和，是各种皮肤问题引起的皮肤瘙痒人群沐浴的最佳选择。
本发明依据GB 15979-2002《一次性使用卫生用品卫生标准》附录C规定的方法，分别在各自的检测条件下对本发明的用于防治皮肤瘙痒的中药沐浴露的抑菌性能及抑菌率稳定性(样品于40±2℃恒温箱中放置3个月)进行检测，具体检测结果如下：
表一：抑菌率检测结果
表二：样品于40±2℃恒温箱中放置3个月后抑菌率检测结果
以上检测结果表明：本发明的用于防治皮肤瘙痒的中药沐浴露，对细菌、真菌均具有较强的抑菌性能，且稳定性良好，保质期可达2年以上。
本发明的用于防治皮肤瘙痒的中药沐浴露，用健康家兔做急性皮肤刺激实验，肉眼观察72小时，结果实验部位无水肿、红斑，表明本发明对皮肤无刺激和致敏性。
本发明的用于防治皮肤瘙痒的中药沐浴露，长效抑制各种致病菌的滋生，安全温和呵护肌肤。符合现代人们追求便捷快速、高效安全的生活主张。
具体实施方式
实施例1
称取苦参15kg、紫苏6kg、黄柏10kg、蛇床子8kg、地肤子7kg、板蓝根28kg、薄荷18kg、金银花10kg，置于煎煮锅中，加入10倍量纯化水，浸泡30分钟。加热沸腾后保持微沸状态煎煮60分钟，200目筛过滤，滤液存于储液罐中。药渣倒回煎煮锅中，加入8倍量纯化水进行第二次煎煮，加热沸腾后保持微沸状态煎煮60分钟，200目筛过滤，滤液存于储液罐中。将两次煎煮的药液合并，于煎煮锅中减压真空浓缩至1.10±0.02g/ml(65±2℃下测定)，200目筛过滤得中药浓缩液。
将40.65kg的纯化水加入调配罐中，开启热水循环通过夹套加热，开启搅拌器。电机转速调至200r/min。温度升至40℃，关闭热水循环。将6kg的乳化增溶剂、12kg的植物源表面活性剂缓慢加入调配罐中，充分搅拌均匀。用0.05kg柠檬酸调节体系pH值至5.0-7.0，缓慢加入40kg的中药提取液，充分搅拌混匀。将0.2kg的防腐剂、0.3kg植物香精依次加入调配罐中，并充分搅拌混匀。将0.8kg的氯化钠缓慢撒入调配罐中充分搅拌混匀，用200目滤布充分过滤。
经检验合格后，灌装制成本发明的用于防治皮肤瘙痒的中药沐浴露。
实施例2
称取苦参17kg、紫苏8kg、黄柏8kg、蛇床子10kg、地肤子9kg、板蓝根25kg、薄荷18kg、金银花8kg，置于煎煮锅中，加入10倍量纯化水，浸泡30分钟。加热沸腾后保持微沸状态煎煮60分钟，200目筛过滤，滤液存于储液罐中。药渣倒回煎煮锅中，加入8倍量纯化水进行第二次煎煮，加热沸腾后保持微沸状态煎煮60分钟，200目筛过滤，滤液存于储液罐中。将两次煎煮的药液合并，于煎煮锅中减压真空浓缩至1.10±0.02g/ml(65±2℃下测定)，200目筛过滤得中药浓缩液。
将29.74kg的纯化水加入调配罐中，开启热水循环通过夹套加热，开启搅拌器。电机转速调至200r/min。温度升至40℃，关闭热水循环。将4kg的乳化增溶剂、15kg的植物源表面活性剂缓慢加入调配罐中，充分搅拌均匀。用0.06kg柠檬酸调节体系pH值至5.0-7.0，缓慢加入50kg的中药提取液，充分搅拌混匀。将0.1kg的防腐剂、0.5kg植物香精依次加入调配罐中，并充分搅拌混匀。将0.6kg的氯化钠缓慢撒入调配罐中充分搅拌混匀，用200目滤布充分过滤。
经检验合格后，灌装制成本发明的用于防治皮肤瘙痒的中药沐浴露。
实施例3
称取苦参12kg、紫苏8kg、黄柏12kg、蛇床子10kg、地肤子8kg、板蓝根30kg、薄荷15kg、金银花7kg，置于煎煮锅中，加入10倍量纯化水，浸泡30分钟。加热沸腾后保持微沸状态煎煮60分钟，200目筛过滤，滤液存于储液罐中。药渣倒回煎煮锅中，加入8倍量纯化水进行第二次煎煮，加热沸腾后保持微沸状态煎煮60分钟，200目筛过滤，滤液存于储液罐中。将两次煎煮的药液合并，于煎煮锅中减压真空浓缩至1.10±0.02g/ml(65±2℃下测定)，200目筛过滤得中药浓缩液。
将49.84kg的纯化水加入调配罐中，开启热水循环通过夹套加热，开启搅拌器。电机转速调至200r/min。温度升至40℃，关闭热水循环。将3kg的乳化增溶剂、16kg的植物源表面活性剂缓慢加入调配罐中，充分搅拌均匀。用0.06kg柠檬酸调节体系pH值至5.0-7.0，缓慢加入30kg的中药提取液，充分搅拌混匀。将0.3kg的防腐剂、0.2kg植物香精依次加入调配罐中，并充分搅拌混匀。将0.6kg的氯化钠缓慢撒入调配罐中充分搅拌混匀，用200目滤布充分过滤。
经检验合格后，灌装制成本发明的用于防治皮肤瘙痒的中药沐浴露。
实施例4
称取苦参18kg、紫苏5kg、黄柏10kg、蛇床子10kg、地肤子10kg、板蓝根20kg、薄荷20kg、金银花12kg，置于煎煮锅中，加入10倍量纯化水，浸泡30分钟。加热沸腾后保持微沸状态煎煮60分钟，200目筛过滤，滤液存于储液罐中。药渣倒回煎煮锅中，加入8倍量纯化水进行第二次煎煮，加热沸腾后保持微沸状态煎煮60分钟，200目筛过滤，滤液存于储液罐中。将两次煎煮的药液合并，于煎煮锅中减压真空浓缩至1.10±0.02g/ml(65±2℃下测定)，200目筛过滤得中药浓缩液。
将45.56kg的纯化水加入调配罐中，开启热水循环通过夹套加热，开启搅拌器。电机转速调至200r/min。温度升至40℃，关闭热水循环。将8kg的乳化增溶剂、10kg的植物源表面活性剂缓慢加入调配罐中，充分搅拌均匀。用0.04kg柠檬酸调节体系pH值至5.0-7.0，缓慢加入35kg的中药提取液，充分搅拌混匀。将0.3kg的防腐剂、0.2kg植物香精依次加入调配罐中，并充分搅拌混匀。将0.9kg的氯化钠缓慢撒入调配罐中充分搅拌混匀，用200目滤布充分过滤。
经检验合格后，灌装制成本发明的用于防治皮肤瘙痒的中药沐浴露。
实施例5
称取苦参16kg、紫苏10kg、黄柏6kg、蛇床子10kg、地肤子5kg、板蓝根30kg、薄荷16kg、金银花10kg，置于煎煮锅中，加入10倍量纯化水，浸泡30分钟。加热沸腾后保持微沸状态煎煮60分钟，200目筛过滤，滤液存于储液罐中。药渣倒回煎煮锅中，加入8倍量纯化水进行第二次煎煮，加热沸腾后保持微沸状态煎煮60分钟，200目筛过滤，滤液存于储液罐中。将两次煎煮的药液合并，于煎煮锅中减压真空浓缩至1.10±0.02g/ml(65±2℃下测定)，200目筛过滤得中药浓缩液。
将34.62kg的纯化水加入调配罐中，开启热水循环通过夹套加热，开启搅拌器。电机转速调至200r/min。温度升至40℃，关闭热水循环。将5kg的乳化增溶剂、14kg的植物源表面活性剂缓慢加入调配罐中，充分搅拌均匀。用0.08kg柠檬酸调节体系pH值至5.0-7.0，缓慢加入45kg的中药提取液，充分搅拌混匀。将0.1kg的防腐剂、0.6kg植物香精依次加入调配罐中，并充分搅拌混匀。将0.6kg的氯化钠缓慢撒入调配罐中充分搅拌混匀，用200目滤布充分过滤。
经检验合格后，灌装制成本发明的用于防治皮肤瘙痒的中药沐浴露。
以上所述，仅是本发明的实施例，并非是对本发明作其他任何形式的限制，而依据本发明所提出的实施例所作的任何修改或等同变化，仍属于本发明所要求保护的范围。
Claims (8)
1.一种用于防治皮肤瘙痒的中药沐浴露，其特征在于包括以下重量份的原料：
所述的中药提取液包括以下重量份的中药原料：
2.根据权利要求1所述的用于防治皮肤瘙痒的中药沐浴露，其特征是所述各组分的重量份数为：
所述的中药提取液包括以下重量份的中药原料：
3.根据权利要求1或2所述的用于防治皮肤瘙痒的中药沐浴露，其特征在于：所述的植物源表面活性剂是由椰油酰胺丙基甜菜碱、烷基糖苷、甜菜碱、椰油酰胺中的一种或几种的混合物。
4.根据权利要求1或2所述的用于防治皮肤瘙痒的中药沐浴露，其特征在于：所述的乳化增溶剂是由聚氧乙烯脱水山梨醇单油酸酯、氢化蓖麻油、辛普高效增溶剂中的一种或几种的混合物。
5.根据权利要求1或2所述的用于防治皮肤瘙痒的中药沐浴露，其特征在于：所述的防腐剂是由谷物发酵产物—A.SAP抗菌剂、植物防腐—萝卜根发酵产物、氯化十六烷基吡啶中的一种或几种的混合物。
6.根据权利要求1或2所述的用于防治皮肤瘙痒的中药沐浴露，其特征在于：所述的中药沐浴露的pH为5.0-7.0。
7.一种制备权利要求1或2所述的用于防治皮肤瘙痒的中药沐浴露的方法，其特征在于：将板蓝根、薄荷、苦参、紫苏、黄柏、蛇床子、地肤子和金银花按照所述重量份数混合，以水为溶剂进行提取，并在提取液中调配所述重量份数的植物源表面活性剂、乳化增溶剂、植物香精、柠檬酸、防腐剂和氯化钠后灌装制成。
8.根据权利要求7所述的用于防治皮肤瘙痒的中药沐浴露的制备方法，其特征在于：包括以下先后顺序制备的步骤：
原料预处理步骤：将板蓝根、薄荷、苦参、紫苏、黄柏、蛇床子、地肤子和金银花八味中药进行精选，清洗，烘干备用；
第一次煎煮步骤：将预处理后的原料按所述重量份数称重混合，置于煎煮锅中，加入8-12倍量纯化水，浸泡30分钟。加热沸腾后保持微沸状态煎煮60分钟，200目筛过滤，滤液存于储液罐中；
第二次煎煮步骤：药渣倒回煎煮锅中，加入6-8倍量纯化水进行第二次煎煮，加热沸腾后保持微沸状态煎煮60分钟，200目筛过滤，滤液存于储液罐中；
混合浓缩步骤：将第一次煎煮步和第二次煎煮步骤所得的药液合并，于煎煮锅中减压真空浓缩至1.10±0.02g/ml，200目筛过滤得中药浓缩液；
再将中药浓缩液于低温冷库中储存，使用时用纯化水稀释10倍，并经200目滤布过滤后，得中药提取液投料；
调配步骤：在所述重量份数的纯化水中加入所述重量份数的乳化增溶剂、植物源表面活性剂充分搅拌均匀；用所述重量份数的柠檬酸调pH值至5.0-7.0，缓慢加入所述重量份数的中药提取液，充分搅拌混匀；将所述重量份数的防腐剂、植物香精依次加入调配罐中，充分搅拌混匀；将所述重量份数的氯化钠缓慢撒入调配罐中，充分搅拌均匀，用200目滤布充分过滤；
灌装步骤：经检验合格后进行灌装。
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| CN113559044A (zh) * | 2021-08-26 | 2021-10-29 | 漳州柚皮王生物技术有限公司 | 一种具有预防皮肤病的沐浴露及其制备方法 |
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