CN106729120A - 一种治疗呃逆的药物及其制备方法 - Google Patents

一种治疗呃逆的药物及其制备方法 Download PDF

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CN106729120A
CN106729120A CN201710144988.2A CN201710144988A CN106729120A CN 106729120 A CN106729120 A CN 106729120A CN 201710144988 A CN201710144988 A CN 201710144988A CN 106729120 A CN106729120 A CN 106729120A
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李子义
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Abstract

本发明公开了一种治疗呃逆的药物及其制备方法,其是由乌梅、白术、白芍、防风、柴胡、川芎、青皮、香附、山药、人参、石斛、麦冬、半夏、厚朴、陈皮、竹茹、石膏、丁香、代赭石、旋复花、太子参按一定重量配比制备而成,本发明药物具有补脾益胃,燥湿和中,理气解郁,健脾补肺,消痰下气的功能,用于治疗呃逆见效快、疗效好,不复发。

Description

一种治疗呃逆的药物及其制备方法
技术领域
[0001] 本发明涉及一种治疗呃逆的药物及其制备方法,属中药领域。
背景技术
[0002] 呃逆即打嗝,指气从胃中上逆,喉间频频作声,声音急而短促。是一个生理上常见 的现象,由横膈膜痉挛收缩引起的。呃逆频繁或持续24小时以上,称为难治性呃逆,多发生 于某些疾病。由于西药治疗副作用大,因此人们对有效治疗呃逆的中药药物存在极大的需 求,至今为止,还没有发现关于本发明的有关报道。
发明内容
[0003] 本发明人依据中医理论的研究和临床试验的反复验证,终于找到了有效治疗呃逆 的药物,从而完成了本发明。
[0004] 本发明的目的就是提供一种有效治疗呃逆的中药组合药物。
[0005] 本发明的另一目的就是提供了该中药组合药物的制备方法。
[0006] 本发明药物是选择乌梅、白术、白芍、防风、柴胡、川芎、青皮、香附、山药、人参、石 斛、麦冬、半夏、厚朴、陈皮、竹茹、石膏、丁香、代赭石、旋复花、太子参进行组合制备的,将这 些药物组合使得各药物功效产生协同作用,从而能够有效治疗呃逆。其中选用乌梅是因为 其性味酸,温,入肝,脾,肺,大肠经,有收敛生津,安蛔驱虫的功能,治久咳,虚热烦渴,久疟, 痢疾,便血,尿血,血崩,蛔厥腹痛,呕吐,钩虫病,牛皮癣,胬肉。选用白术是因为其性味苦 甘,温,入脾、胃经,有补脾,益胃,燥湿,和中的功能,治脾胃气弱,不思饮食,倦怠少气,虚 胀,泄泻,痰饮,水肿,黄疸,湿痹,小便不利,头晕,自汗,胎气不安。选用白芍是因为其性味 苦酸,凉,入肝、脾经,有养血柔肝,缓中止痛,敛阴收汗的功能,治胸腹胁肋疼痛,泻痢腹痛, 自汗盗汗,阴虚发热,月经不调,崩漏,带下。选用防风是因为其性味辛甘,温,入膀胱、肺、脾 经,有发表,祛风,胜湿,止痛的功能,治外感风寒,头痛,目眩,项强,风寒湿痹,骨节酸痛,四 肢挛急,破伤风。选用柴胡是因为其性味苦,凉,入肝、胆经,有和解表里,疏肝,升阳的功能, 治寒热往来,胸满胁痛,口苦耳聋,头痛目眩,疟疾,下利脱肛,月经不调,子宫下垂。选用川 芎是因为其性味辛,温,入肝、胆经,有行气开郁,祛风燥湿,活血止痛的功能,治风冷头痛旋 晕,胁痛腹疼,寒痹筋挛,经闭,难产,产后瘀阻块痛,痈疽疮疡。选用青皮是因为其性味苦 辛,微温,入肝、胆经,有疏肝破气,散结消痰的功能,治胸胁胃脘疼痛,疝气,食积,乳肿,乳 核,久疟癖块。选用香附是因为其性味辛微苦干,平,入肝、三焦经,有理气解郁,止痛调经的 功能,治肝胃不和,气郁不舒,胸腹胁肋胀痛,痰饮痞满,月经不调,崩漏带下。选用山药是因 为其性味甘,平,入肺、脾、肾经,有健脾,补肺,固肾,益精的功能,治脾虚泄泻,久痢,虚劳咳 嗽,消渴,遗精、带下,小便频数。选用人参是因为其性味甘微甘,温,入脾、肺经,有大补元 气,固脱生津,安神的功能,治劳伤虚损,食少,倦怠,反胃吐食,大便滑泄,虚咳喘促,自汗暴 脱,惊悸,健忘,眩晕头痛,阳萎,尿频,消渴,妇女崩漏,小儿慢惊及久虚不复,一切气血津液 不足之症。选用石斛是因为其性味甘淡微咸,寒,入有、肺、肾经,有生津益胃,清热养阴的功 能,治热病伤津,口干烦喝,病后虚热,阴伤目暗。选用麦冬是因为其性味甘微苦,寒,入肺、 胃、心经,有养阴润肺,清心、除烦,益胃生津的功能,治肺燥干咳,吐血,略血,肺痿,肺痈,虚 劳烦热,清渴,热病津伤,咽干口燥,便秘。选用半夏是因为其性味辛,温,有毒,入脾、胃经, 有燥湿化痰,降逆止呕,清痞散结的功能,治湿痰冷饮呕吐,反胃,咳喘痰多,我膈胀满,痰厥 头痛,头晕不眠,外消痈肿。选用厚朴是因为其性味苦辛,温,入脾、胃、大肠经,有温中,下 气,燥湿,消痰的功能,治胸腹痞满胀痛,反胃、呕吐,宿食不消,痰饮喘咳,寒湿泻痢。选用陈 皮是因为其性味苦、辛,温,归肺、脾经,有理气健脾,燥湿化痰的功能,治胸脘胀满,食少吐 泻,咳嗽痰多。选用竹茹是因为其性味甘,凉,入胃、胆经,有清热,凉血,化痰,止吐的功能, 治烦热呕吐、呃逆,痰热咳喘,吐血,衄血,崩漏,恶阻,胎动,惊癎。选用石膏是因为其性味辛 甘,寒,入肺、胃经,生用有解肌清热,除烦止渴的功能,治热病壮热不退,心烦神昏,谵语发 狂,口渴咽干,肺热喘急,中暑自汗,胃火头痛、牙痛,热毒壅盛,发斑发疹,口舌生疮,煅敷生 肌敛疮,外治痈疽疮疡,溃不收回,汤火烫伤。选用丁香是因为其性味辛,温,入胃、脾、肾经, 有温中,暖肾,降逆的功能,治呃逆,呕吐,反胃,泻痢,心腹冷痛,痃癖,疝气,癣疾。选用代赭 石是因为其性味苦甘,平,入肝、胃、心胞经,有平肝镇逆,凉血止血的功能,治噫气呕逆,噎 膈反胃,哮喘,惊癎,吐血,鼻衄,肠风,痔痿,崩漏带下。选用旋复花是因为其性味咸,温,入 肺、肝、胃经,有消痰,下气,软坚,行水的功能,治胸中痰结,胁下胀满,咳喘,呃逆,唾如胶 漆,心下痞硬,噫气不除,大腹水肿。选用太子参是因为其性味甘苦,微温,入心、脾、肺三经, 有补肺、健脾的功能,治肺虚咳嗽,脾虚食少,心t季目汗,精神疲之。
具体实施方式
[0007] 本发明组分的药物用量也是发明人经过大量摸索总结得出的,各组分的用量在下述重 量范围内都具有较好的疗效: 乌梅6-10克,白术10-20克,白芍10-20克,防风5-15克,柴胡5-15克,川芎5-15克,青皮 5-15克,香附5-15克,山药5-15克,人参5-15克,石斛10-20克,麦冬5-15克,半夏10-14克,厚 朴5-15克,陈皮4-8克,竹茹5-15克,石膏10-20克,丁香10-20克,代赭石15-25克,旋复花15-25克,太子参15-25克。
[0008] 优选为: 乌梅8克,白术15克,白芍15克,防风10克,柴胡10克,川考10克,青皮10克,香附10克,山 药10克,人参10克,石斛15克,麦冬10克,半夏12克,厚朴10克,陈皮6克,竹茹10克,石膏15 克,丁香15克,代赭石20克,旋复花20克,太子参20克。
[0009] 本发明药物的制备方法如下 一、备料 1、 乌梅:拣净杂质,筛去灰肩,洗净,晒干; 2、 白术:拣净杂质,用水浸泡,泡后捞出,润透,切片,晒干; 3、 白芍:拣去杂质,分开大小个,用水浸泡至八成透,捞出,晒晾,润至内外湿度均匀,切 片,干燥; 4、 防风:除去残茎,用水浸泡,捞出,润透切片,晒干; 5、 柴胡:拣去杂质,除去残茎,洗净泥沙,捞出,润透后及时切片,随即晒干; 6、 川考:拣去杂质,分开大、小个,用水浸泡,晒晾,闷润后切片,干燥; 7、 青皮:拣净杂质,用水浸泡,捞出,润透,切片,晒干; 8、 香附:拣去杂质,礙成碎粒,鑛去细毛及细末; 9、 山药:拣净杂质,用水浸泡至山药中心部软化为止,捞出稍晾,切片晒干或烘干; 10、 人参:除去户头,切段; 11、 石斛:取干燥的石斛,用水泡约至八成透,闷润,除去残根及黑枝,切段,撞去薄膜, 晒干; 12、 麦冬:拣净杂质,用水浸泡,捞出,润透后抽去心,再洗净晒干; 13、 半夏:拣去杂质,筛去灰肩; 14、 厚朴:用水浸泡捞出,润透后刮去粗皮,洗净,切丝,晾干; 15、 陈皮:取原药材,除去杂质及变黑的果皮,抢水洗净,润软,切丝,晒干或低温干燥, 筛去灰肩; 16、 竹茹:除去硬竹签、杂质,抖掉灰肩,揉成小团或切段; 17、 石膏:去净杂石,洗净泥土,打碎成小块; 18、 丁香:找去杂质、花梗,筛去灰肩,用时捣碎; 19、 代赭石:除去杂质,砸碎,过筛; 20、 旋复花:拣净杂质,除去梗叶,筛去泥土; 21、 太子参:摘除须根,晒干。
[0010] 二、制备 1、 将所述重量的乌梅、白术、白芍、防风、柴胡、川考、青皮、香附、山药、人参、石斛、麦 冬、半夏、厚朴、陈皮、竹茹、石膏、丁香、代赭石、旋复花、太子参放入煎药容器内,加水6倍 量,浸泡120分钟后,武火煎煮沸腾,再用文火煎煮20分钟,过滤得第一次煎煮液,将第一次 煎煮液倒入容器内; 2、 将过滤的药渣加水5倍量,武火煮沸,再用文火煎煮20分钟,过滤得第二次煎煮液; 3、 将两次煎煮液混合搅拌均匀,分为2剂服用。
[0011] 组方中郁金有补脾益胃,燥湿和中的功能为君药;香附有理气解郁的功能;山药有 健脾补肺,固肾益精的功能,二者为臣药,三味药共同发挥补脾益胃,燥湿和中,理气解郁, 健脾补肺的作用,治疗呃逆效力全面,且以补脾益胃,理气解郁,健脾补肺为主可治本,陈皮 有理气健脾,燥湿化痰的功能为佐药,旋复花有消痰下气,软坚行水的功能为使药,与下余 诸药是治标。
[0012] 本发明药物具有补脾益胃,燥湿和中,理气解郁,健脾补肺,消痰下气的功能,用于 治疗呃逆,疗程短、见效快、治愈后不复发。
[0013] 以下通过试验例来进一步阐述本发明所述药物的有益效果,这些试验例包括本发 明药物的动物毒性试验报告和临床疗效观察资料。
[0014] [试验例1]本发明药物的动物毒性试验报告: 取家兔30只,雌雄兼用,体重2.0—2.5kg,分两组,每组15只,其中一组为超剂量试验 组,另一组为正常量试验组。超常量组为20ml/kg,正常量为10ml/kg,给药方式为灌胃法给 药,每天两次,连服7天,每天观察给药反应,结果表明二组家兔活动、饮食正常,药物无不良 毒副作用。
[0015] [试验例2]本发明药物的临床疗效观察 1、一般资料 收治呃逆门诊患者共23例。
[0016] 2、诊断标准 呃逆为膈肌痉挛引起的收缩运动,吸气时声门突然关闭发出一种短促的声音。可发于 单侧或双侧的膈肌。有的可持续较长时间而成为顽固性呃逆。
[0017] 3、治疗方法 选用上述药剂,给患者服用,每次服用1剂,每天早、晚各服1次,连续服用7天。
[0018] 4、疗效评定标准 显效:呃逆症状消失,恢复正常,痊愈; 好转:呃逆症状明显好转,逐步恢复正常; 无效:达不到好转标准者。
[0019] 5、治疗结果(见下表)
Figure CN106729120AD00071
在上述治疗中,用本发明药物治疗呃逆患者23例,结果显效21例,显效率为91.30%,好 转2例,总有效率为100%。

Claims (3)

1. 一种治疗呃逆的药物,其特征在于:它是由下列重量范围内的原料药制成: 乌梅6-10克,白术10-20克,白芍10-20克,防风5-15克,柴胡5-15克,川芎5-15克,青皮 5-15克,香附5-15克,山药5-15克,人参5-15克,石斛10-20克,麦冬5-15克,半夏10-14克,厚 朴5-15克,陈皮4-8克,竹茹5-15克,石膏10-20克,丁香10-20克,代赭石15-25克,旋复花15-25克,太子参15-25克。
2. 根据权利要求1所述的药物,其中各原料药的用量为: 乌梅8克,白术15克,白芍15克,防风10克,柴胡10克,川考10克,青皮10克,香附10克,山 药10克,人参10克,石斛15克,麦冬10克,半夏12克,厚朴10克,陈皮6克,竹茹10克,石膏15 克,丁香15克,代赭石20克,旋复花20克,太子参20克。
3. 根据权利要求1或2所述药物的制备方法,它包括下列步骤: (一) 备料 (1) 乌梅:拣净杂质,筛去灰肩,洗净,晒干; (2) 白术:拣净杂质,用水浸泡,泡后捞出,润透,切片,晒干; (3) 白芍:拣去杂质,分开大小个,用水浸泡至八成透,捞出,晒晾,润至内外湿度均匀, 切片,干燥; (4) 防风:除去残茎,用水浸泡,捞出,润透切片,晒干; (5) 柴胡:拣去杂质,除去残茎,洗净泥沙,捞出,润透后及时切片,随即晒干; (6) 川芎:拣去杂质,分开大、小个,用水浸泡,晒晾,闷润后切片,干燥; (7) 青皮:拣净杂质,用水浸泡,捞出,润透,切片,晒干; (8) 香附:拣去杂质,礙成碎粒,鑛去细毛及细末; (9) 山药:拣净杂质,用水浸泡至山药中心部软化为止,捞出稍晾,切片晒干或烘干; (10) 人参:除去户头,切段; (11) 石斛:取干燥的石斛,用水泡约至八成透,闷润,除去残根及黑枝,切段,撞去薄膜, 晒干; (12) 麦冬:拣净杂质,用水浸泡,捞出,润透后抽去心,再洗净晒干; (13) 半夏:拣去杂质,筛去灰肩; (14) 厚朴:用水浸泡捞出,润透后刮去粗皮,洗净,切丝,晾干; (15) 陈皮:取原药材,除去杂质及变黑的果皮,抢水洗净,润软,切丝,晒干或低温干燥, 筛去灰肩; (16) 竹茹:除去硬竹签、杂质,抖掉灰肩,揉成小团或切段; (17) 石膏:去净杂石,洗净泥土,打碎成小块; (18) 丁香:找去杂质、花梗,筛去灰肩,用时捣碎; (19) 代赭石:除去杂质,砸碎,过筛; (20) 旋复花:拣净杂质,除去梗叶,筛去泥土; (21) 太子参:摘除须根,晒干; (二) 制备 (1)将所述重量的乌梅、白术、白芍、防风、柴胡、川芎、青皮、香附、山药、人参、石斛、麦 冬、半夏、厚朴、陈皮、竹茹、石膏、丁香、代赭石、旋复花、太子参放入煎药容器内,加水6倍 量,浸泡120分钟后,武火煎煮沸腾,再用文火煎煮20分钟,过滤得第一次煎煮液,将第一次 煎煮液倒入容器内; (2) 将过滤的药渣加水5倍量,武火煮沸,再用文火煎煮20分钟,过滤得第二次煎煮液; (3) 将两次煎煮液混合搅拌均匀,分为2剂服用。
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Application publication date: 20170531