CN106728339A - It is a kind of to promote Chinese medicine preparation of sow lactation and preparation method and application - Google Patents

It is a kind of to promote Chinese medicine preparation of sow lactation and preparation method and application Download PDF

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Publication number
CN106728339A
CN106728339A CN201710139854.1A CN201710139854A CN106728339A CN 106728339 A CN106728339 A CN 106728339A CN 201710139854 A CN201710139854 A CN 201710139854A CN 106728339 A CN106728339 A CN 106728339A
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sow
chinese medicine
pangolin
preparation
oral liquid
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CN201710139854.1A
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Inventor
乔家运
李海花
朱琪
李玉鹏
王文杰
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Tianjin Institute of Animal Husbandry and Veterinary Science
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Tianjin Institute of Animal Husbandry and Veterinary Science
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/36Skin; Hair; Nails; Sebaceous glands; Cerumen; Epidermis; Epithelial cells; Keratinocytes; Langerhans cells; Ectodermal cells
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/23Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A61K36/232Angelica
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/23Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A61K36/236Ligusticum (licorice-root)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/25Araliaceae (Ginseng family), e.g. ivy, aralia, schefflera or tetrapanax
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/28Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A61K36/284Atractylodes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/34Campanulaceae (Bellflower family)
    • A61K36/344Codonopsis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/36Caryophyllaceae (Pink family), e.g. babysbreath or soapwort
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/42Cucurbitaceae (Cucumber family)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/80Scrophulariaceae (Figwort family)
    • A61K36/804Rehmannia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0053Mouth and digestive tract, i.e. intraoral and peroral administration
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/08Solutions
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K2236/00Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30Extraction of the material
    • A61K2236/33Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/331Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K2236/00Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30Extraction of the material
    • A61K2236/39Complex extraction schemes, e.g. fractionation or repeated extraction steps

Abstract

The invention discloses a kind of Chinese medicine preparation preparation method of promotion milking sow lactation.It is made up of the 30g of pangolin 15, the 35g of the stem pith of the rice-paper plant 20, the 20g of the seed of cowherb 15,10 20g that play both sides of the street, the 60g of luffa 30, the 35g of Radix Angelicae Sinensis 15, the 40g of Radix Codonopsis 20, the 35g of the bighead atractylodes rhizome 15, the 30g of Ligusticum wallichii 20, the 35g of cultivated land 20, and tune is made oral liquid with sucrose, phosphatide and sodium citrate(Sow milk passes through oral liquid).The present invention further discloses this oral liquid the total serum protein of milking sow, albumin, globulin, Archon than, the aspect such as growth hormone, capacity of milk secretion of sow application.Result shows:Oral liquid is gavaged by lactating sow, the milk performance of sow can be promoted, improve the growth performance of suckling pig.

Description

It is a kind of to promote Chinese medicine preparation of sow lactation and preparation method and application
Technical field
The invention belongs to farm animals nutrition technique research field, it is related to promote the Chinese medicine preparation preparation side of sow lactation Method.
Background technology
In the development model of modern pig-breeding intensive manufacture, sow is key link, especially lactating sow, is undertaken Raising newborn piglet, makes the important task of overall swinery sustainable development.
Pig breast is the unique channel that nutrition is obtained after piglet birth, and the quality of lactation amount and milk composition quality directly affects son A series of growth and development state after pig birth, growth performance and healthy development to piglet play an important roll.Contain in pig breast There are the nutriments such as lactose, lactoprotein, butterfat and bioactie agent.And milk yield of sow number and milk quality be subject to mother The influence of many factors such as pig feed intake, mammary development situation and hormonal readiness.In modern intensive production, often there is body in sow Condition is too obese, overnutrition, upsets the phenomenon of organism endocrine, influences the lactation amount in its postpartum.Sow Postpartum constitution is weak, Disease ability is resisted, lactation is also have impact on.
At present, frequently with various drug therapies, the long-term abuse of various medicines, the especially use of antibiotic can induce disease The drug resistance of pathogenic microorganism, it is often more important that chemicals causes medicine possibly through being connected between lactating sow in piglet body Residual, so that do harm to huamn body.
The content of the invention
This research gavages the current oral liquid of sow milk by lactating sow, can adjust milk yield of sow and quality, improves Piglet growth performance.
To achieve the above object, the invention discloses following technology contents:
A kind of Chinese medicine preparation of promotion sow lactation(Sow milk passes through oral liquid), it is characterised in that it is by the original of following weight Material composition:
Pangolin 15-30g stem pith of the rice-paper plant 20-35g seeds of cowherb 15-20g plays both sides of the street 10-20g luffa 30-60g Radix Angelicae Sinensis 15-35g parties Ginseng 20-40g bighead atractylodes rhizome 15-35g Ligusticum wallichii 20-30g cultivated lands 20-35g is adjusted and is made oral liquid with sucrose, phosphatide and sodium citrate.
The Chinese medicine preparation of currently preferred promotion sow lactation(Sow milk passes through oral liquid), it is characterised in that it be by The raw material composition of following weight:
Pangolin 20g, stem pith of the rice-paper plant 30g, seed of cowherb 20g, the 20g that plays both sides of the street, luffa 60g, Radix Angelicae Sinensis 35g, Radix Codonopsis 35g, the bighead atractylodes rhizome 25g, Ligusticum wallichii 25g, cultivated land 30g, tune are made 1 with sucrose, phosphatide and sodium citrate:5 oral liquids.
The present invention further discloses the preparation method of the Chinese medicine preparation for promoting sow lactation:
(1)Traditional vinegar system of pangolin combines modern superfine communication technique
Traditional vinegar system:Take sand to put in pot, after making popular with high heat, add net pangolin of the same size, stir to heaving, in golden yellow During color, take out, weed out sand, pour into vinegar liquid in time, stir, slightly soak, pull out, dry.Crush and use:Supersonic airstream high frequency Vibration ultramicro grinding, crosses 400 mesh sieves standby.
(2)Concentration is slightly considered in remaining herbal medicine immersion boiling
Chinese medicine another name weight, plus 10 times of amount water immersion 2h, boiling are extracted twice, merge extract solution and be concentrated into 5 times of amounts, and coarse filtration is standby With.
(3)Medicine solid-liquid emulsified mixed suspension is closed in configuration
Pangolin Ultramicro-powder and Chinese medicine extract are sufficiently mixed tune with sucrose, phosphatide and sodium citrate to scale, are added The emulsifying device that homogenizes carries out emulsification processing.
(4)Quantitative separating
Packing cubing, every bottle of 1500mL.
(5)Quality inspection is encapsulated
Finished product should be well mixed, color and luster is consistent.Packaging is using brown sealed polyethylene plastic bag, and external application plastic-aluminum vacuum is self-styled.More Good prevents discoloration, decomposes, so as to guaranteed quality and take effect.
The present invention further discloses promoting the Chinese medicine preparation of sow lactation for adjusting milk yield of sow and quality, carry Application in terms of piglet growth performance high.Particularly:Total protein, albumin, globulin, Archon ratio and life in lactating sow serum Hormone-content long, capacity of milk secretion of sow.Result of the test shows:Gavaging the current oral liquid of sow milk to test group lactating sow can show Write(P < 0.05)Capacity of milk secretion of sow and quality are improved, while test group is notable(P < 0.05)Improve the wean nest of 28d piglets Weight.
The present invention is principle to adjust lactation amount and quality, by improving body growth hormonal readiness with protein content in breast To improve body milk performance, effect is significant.
With rare Chinese medicine pangolin as main ingredient in side in formula of the invention, it is aided with the stem pith of the rice-paper plant, the seed of cowherb and Radix Angelicae Sinensis etc., its Middle pangolin consumption is not to be exceeded 30g.
According to the various Chinese medicine physicochemical properties and active ingredient in this formula, the preparation technology to traditional Chinese powder medicine does the present invention System optimization, at utmost playing its drug action.We have mainly investigated following condition in development process:
(1)Rare medicinal herbs pangolin ultramicro grinding emulsified mixed suspension:
Crucial medicinal material pangolin in formula carries out supersonic airstream dither ultramicro grinding(Cross 400 mesh sieves), Ultramicro-powder With Chinese medicine extract emulsified mixed suspension.
(2)Soaking cooking coarse filtration:
Each Chinese medicine is all screened by the different immersions of its physicochemical property and digestion time.
(3)Chinese medicine extract configuration packing:
Each Chinese medical extract is mixed to scale, fine filtering packing again after sedimentation 2h.By using weight The contrast of method and volumetric method, we determine to use gravimetric method, and this method dosage is accurate, and error is small, easily adjustment.
(4)Packaged sterile:
Packaging is using brown vinyon bottle, external application plastic-aluminum vacuum seal.Discoloration is preferably prevented, is decomposed, so that guaranty Matter and take effect..
The pharmacological action of the Chinese medicine used in the present invention is as follows:
Pangolin
Process:Take sand to put in pot, after making popular with high heat, add net pangolin of the same size, stir to heaving, in golden yellow When, take out, sand is weeded out, pour into vinegar liquid in time, stir, slightly soak, pull out, dry.Pangolin is per 1000g rice vinegar 300mL.
Pharmacology:This product is stimulated the menstrual flow lower breast, and detumescence and apocenosis search the function of wind and removing obstruction in channels, agalactia etc. obstructed for Amenorrhea Disease.
The stem pith of the rice-paper plant
Process:Impurity is removed, sheet is cut.
Pharmacology:Reducing fever and causing diuresis, the lower breast of ventilation.For damp-warm syndrome urine, the puckery pain of gonorrhoea, oedema oliguria, agalactia.
The seed of cowherb
Process:The net seed of cowherb is taken, is put in frying container, heated with moderate heat, stir-fry bursts into major part is spent in vain, and taking-up is cooled.
Pharmacology:In invigorate blood circulation, lower breast, promoting diuresis for stranguria.For lack of lactation after delivery, Amenorrhea, stranguria, difficult urination.
Play both sides of the street
Process:Remove impurity and total carpopodium, cleaning, drying.
Pharmacology:Dispelling, collateral-activating, Li Shui stimulates the menstrual flow.For joint pain, numbness contracture, oedema turgor, the few Amenorrhea of breast.
Luffa
Process:Remove residual seed and crust, segment.
Pharmacology:Dredging collateral, promoting blood circulation, wind-dispelling.For numbness pain contraction, distending pain in the chest and hypochondrium, alactation.
Radix Angelicae Sinensis
Process:(RADIX ANGELICAE SINEINSIS) takes crude drug, removes impurity, cleans, and slightly moistens, shave, dries or low temperature drying.Weed out chip.
Pharmacology:Enrich blood, menstruation regulating relaxes bowel.Lost for deficiency of blood body, lusterless complexion, refreshing tired body is tired, the deficiency of blood is appointed in gestation punching, Bitterly, or vim and vigour stagnate abdominal pain, and few abdomen pain, prolonged lochia, trusted subordinate has a pain, blood deficiency and constipation etc..
Radix Codonopsis
Process:Crude drug is taken, except removing LU, is cleaned, run through, cut sheet, dried.
Pharmacology:Tool tonifying middle-Jiao and Qi, strengthening spleen and tonifying lung effect.For spleen and lung weakness, shortness of breath palpitations, anorexia and loose stool, virtual asthma cough, Heat Diabetes.
The bighead atractylodes rhizome
Process:Crude drug is taken, impurity is removed, size is separated, run through with water, cuts sheet, is dried.Weed out chip.
Pharmacology:With strengthening the spleen and replenishing qi, eliminate dampness and have diuretic effect, hidroschesis, antiabortive function.For spleen eating less, abdominal distention diarrhea, phlegm and retained fluid Feel dizzy and heart palpitations, oedema, spontaneous perspiration, fetal irritability etc..
Ligusticum wallichii
Process:Crude drug is taken, impurity is removed, size is separate, cleaned.People's crust degree of being can be pinched with bubble to nail, is taken out, billows Thoroughly, shave, dries.Weed out chip.
Pharmacology:With blood-activating and qi-promoting, the function of wind-expelling pain-stopping.For having difficult labour, postpartum stasis stomachache, side of body rib has a pain, and has a headache, Arthralgia pain due to rheumatism and traumatic injury, sore, carbuncle and painful swelling etc..
Cultivated land
Process:The clean dried rhizome of rehmannia is taken, is put in suitable container, Steam by water bath to black profit takes out, and shines to 1,000, cuts sheet, does It is dry.Weed out chip.
Pharmacology:With nourishing yin and supplementing blood, the function of beneficial to spirit and marrow.For the deficiency of liver-yin and kidney-yin, soreness and weakness of waist and knees, osteopyrexia and fever, interior heat Quench one's thirst, blood deficiency chlorosis, palpitation and severe palpitation.
More detailed description of the present invention is as follows:
1 materials and methods
1.1 Chinese medicine preparation prescriptions
Title:Sow milk passes through oral liquid
Formula:It is pangolin 20g, stem pith of the rice-paper plant 30g, seed of cowherb 20g, the 20g that plays both sides of the street, luffa 60g Radix Angelicae Sinensis 35g, Radix Codonopsis 35g, white Art 25g, Ligusticum wallichii 25g, cultivated land 30g, tune are made 1 with sucrose, phosphatide and sodium citrate:5 oral liquids.
Indication:Logical breast, the promoting flow of qi and blood circulation.We to sow postpartum 2-3d breasts less or agalasisa effect is obvious.
Usage and dosage:Direct or water is adjusted and gavaged, and once a day, a 300mL, combination 5 days is a course for the treatment of to sow consumption, Drug withdrawal 1-3 days, continues next course for the treatment of, so circulation.
Experiment uses corn-soybean meal diet, with reference to NRC(1998)The feeding standard of middle lactating sow is foundation, basis Daily ration composition is as follows:
Corn 50.50, wheat 12, dregs of beans 18.00, wheat bran 9.85, corn protein powder 4, soya-bean oil 1.75, stone flour 0.8, lysine 0.38th, calcium monohydrogen phosphate 1.27, salt 0.45, premix 1(It is commercially available:Above raw material is commercially available).
Digestible energy(MJ/kg):13.66th, thick protein(%):16.89th, lysine(%):0.96th, calcium(%):0.91st, total phosphorus (%):0.85.
Note:Vitamin, mineral trace element, amino acid etc. necessary to body are included in premix.
1.2 experimental designs
Experiment selection parity and the expected date of childbirth close latter half of gestation(Du × long × big)Sow 12, body condition health, by completely with Machine divides into two treatment, blank control group:Feeding basal diet, but Chinese medicine preparation is not gavaged;Test group:Feeding basic day Grain, and gavage Chinese medicine preparation.Each treatment 6 repetitions, each repeat 1 sow, formal test in after childbirth, to piglet The wean of 28 ages in days terminates.
1.3 feedings and managements
Experiment sow is transferred to same childbirth house high bed raising antenatal.The raising of 15 day laundering period is first passed through, is opened within 7 days before the expected date of childbirth Begin to gavage appropriate Chinese medicine preparation to test group sow(Preliminary trial period), until 28 ages in days wean.Test pig raises pipe using identical Reason and environmental condition, dry mash feeding, free choice feeding and drinking-water carry out disinfection by pig farm feeding and management code and clearly during experiment The work such as clean health.
1.4 Testing index and method
1.4.1 Milking ability
Claim 1 age in days and 28 ages in days that the body weight of piglet is tested per nest respectively, calculate Milking ability.
1.4.3 Serum Indexes
In puerperal 18th d and 28 d early mornings, the sow ear vein of each treatment group is taken a blood sample with vacuum test tube 10ml, room temperature places 30min, 3000r/min centrifugation 10min, takes supernatant and is sub-packed in 1.5ml centrifuge tubes.
Growth hormone(GH):Kit is purchased from French Bake Man, is operated by kit requirement;With full-automatic biochemical point Analyzer(Step auspicious BS-200)Determine total protein in sow serum(TP), albumin(ALB)Concentration, calculate globulin concentration and white Ball ratio.Kit builds up Co., Ltd of Bioengineering Research Institute purchased from Nanjing, is operated by kit requirement.
1.5 statistical analyses
Statistics uses one-way ANOVA(IBM SPSS Statistics 20.0)Variance test is analyzed.In text data with " means standard deviation " is represented, probabilityP <Significant difference, probability are thought when 0.05P <Think that difference is extremely notable when 0.01.
2 results and analysis
2.1 Milking abilities
As shown in Table 1, the 28 ages in days wean nest counterpoise and Milking ability of test group piglet are notable(P<0.05)Improve.Therefore, to secreting Wet nurse pig gavages the current oral liquid of sow milk and can improve the Milking ability of 28 age in days weanling pig nest counterpoises and sow.
Influence of the Chinese medicine preparation to capacity of milk secretion of sow is added in the daily ration of table 1
Note:Colleague's shoulder mark in table, lowercase is different, represents that control group is notable with test group result difference(p<0.05);Capitalization Alphabetical different expression control groups are extremely notable with test group result difference(p<0.01).
2.2 Serum Indexes
The content of total protein is relevant with the absorption of body protein and metabolism status in serum.Test group total protein content is high, says The bright digestion that improve sow to protein, absorption.Albumin can be used for repair tissue, maintain plasma osmolarity, influence body It is immunized.Globulin content has reacted the antibody level of body to a certain extent.Growth hormone can improve animal growth rate, Promote muscle growth, be also one of important hormone of regulation mammogenesis.As shown in Table 2, compared with control group, test group is notable (P < 0.05)Improve growth hormone concentration, total protein and globulin content, 18 ages in days and 28 in 18 ages in days and 28 age in days serum Age in days albumin content is respectively increased 7.38% and 8.29%.Therefore, Chinese medicine preparation may advantageously facilitate lactating sow to nutriment Digest and assimilate and mammogenesis so that promote lactation and improve breast in albumen and antibody content, further promote piglet growth Development.
Influence of the Chinese medicine preparation to sow Serum Indexes is added in the daily ration of table 2
Note:Colleague's shoulder mark in table, lowercase is different, represents that control group is notable with test group result difference(p<0.05);Capitalization Alphabetical different expression control groups are extremely notable with test group result difference(p<0.01).
The present invention gavages Chinese medicine preparation to puerperal sow(Sow milk passes through oral liquid), the current oral liquid of sow milk enters Safety experiment is gone, its method is as follows:
1 step:
(1)Material and method:Du × the length of selection childbirth 1d × big piglet sow 6, clinical health, development are normal, experimental period 28 days, sow and piglet poisoning manifestations and death condition are observed in experimental period at any time.
(2)The feed for lactating sow raw material composition of feeding:
Corn 52.50, wheat 10, dregs of beans 17.50, wheat bran 10.35, corn protein powder 4, soya-bean oil 1.75, stone flour 0.8, bad ammonia Sour 0.38, calcium monohydrogen phosphate 1.27, salt 0.45, premix 1.
The current oral liquid of sow milk is gavaged by the 350ml amounts of gavaging to lactating sow to be tested.
2 results:The current oral liquid of sow milk is gavaged to lactating sow, continuous feeding 28 days has no obvious intoxicating phenomenon, Without death in observation period, each main organs of cut open inspection show no obvious abnormalities.
3 conclusions:By the 350ml amounts of gavaging the current oral liquid of sow milk, feeding effect safety are gavaged to lactating sow.
The good effect that the Chinese medicine preparation of promotion sow lactation disclosed by the invention has compared with prior art exists In:
Significantly(P < 0.05)Improve total protein, globulin and growth in Milking ability, weanling pig nest counterpoise, the serum of sow Hormone-content.
Specific embodiment
The present invention is described below by specific embodiment.Unless stated otherwise, technological means used in the present invention It is method known in those skilled in the art.In addition, embodiment is interpreted as illustrative, it is not intended to limit the present invention Scope, the spirit and scope of the invention are limited only by the claims that follow.To those skilled in the art, without departing substantially from this On the premise of invention spirit and scope, the various changes that are carried out to the material component and consumption in these embodiments or change Belong to protection scope of the present invention.Raw materials used and various Chinese medicines of the invention are commercially available.
Embodiment 1
The current oral liquid of sow milk is made up of the raw material of following weight:
Pangolin 20g, stem pith of the rice-paper plant 30g, seed of cowherb 20g, the 20g that plays both sides of the street, luffa 60g, Radix Angelicae Sinensis 35g, Radix Codonopsis 35g, the bighead atractylodes rhizome 25g, Ligusticum wallichii 25g, cultivated land 30g, tune are made 1 with sucrose, phosphatide and sodium citrate:5 oral liquids.
Embodiment 2
The current oral liquid of sow milk it be made up of the raw material of following weight:
Pangolin 15g, stem pith of the rice-paper plant 25g, seed of cowherb 15g, the 25g that plays both sides of the street, luffa 50g, Radix Angelicae Sinensis 35g, Radix Codonopsis 35g, the bighead atractylodes rhizome 35g, Ligusticum wallichii 30g, cultivated land 35g, tune are made 1 with sucrose, phosphatide and sodium citrate:5 oral liquids.
Embodiment 3(Embodiment 1-2)
Promote the preparation method of the Chinese medicine preparation of sow lactation:
(1)Traditional vinegar system of pangolin combines modern superfine communication technique
Traditional vinegar system:Take sand to put in pot, after making popular with high heat, add net pangolin of the same size, stir to heaving, in golden yellow During color, take out, weed out sand, pour into vinegar liquid in time, stir, slightly soak, pull out, dry.Crush and use:Supersonic airstream high frequency Vibration ultramicro grinding, crosses 400 mesh sieves standby.
(2)Concentration is slightly considered in remaining herbal medicine immersion boiling
Chinese medicine another name weight, plus 10 times of amount water immersion 2h, boiling are extracted twice, merge extract solution and be concentrated into 5 times of amounts, and coarse filtration is standby With.
(3)Medicine solid-liquid emulsified mixed suspension is closed in configuration
Pangolin Ultramicro-powder and Chinese medicine extract are sufficiently mixed tune with sucrose, phosphatide and sodium citrate to scale, are added The emulsifying device that homogenizes carries out emulsification processing.
(4)Quantitative separating
Packing cubing, every bottle of 1500mL.
(5)Quality inspection is encapsulated
Finished product should be well mixed, color and luster is consistent.Packaging is using brown sealed polyethylene plastic bag, and external application plastic-aluminum vacuum is self-styled.More Good prevents discoloration, decomposes, so as to guaranteed quality and take effect.

Claims (5)

1. it is a kind of promote sow lactation Chinese medicine preparation, it is characterised in that it is made up of the dry product of following raw material medicaments, each taste medicine Shared weight is as follows:
Pangolin 15-30g, stem pith of the rice-paper plant 20-35g, seed of cowherb 15-20g, the 10-20g that plays both sides of the street, luffa 30-60g,
Radix Angelicae Sinensis 15-35g, Radix Codonopsis 20-40g, bighead atractylodes rhizome 15-35g, Ligusticum wallichii 20-30g, cultivated land 20-35g.
2. the Chinese medicine preparation of sow lactation is promoted described in claim 1, it is characterised in that it is made up of the raw material of following weight:
Pangolin 20g, stem pith of the rice-paper plant 30g, seed of cowherb 20g, the 20g that plays both sides of the street, luffa 60g, Radix Angelicae Sinensis 35g, Radix Codonopsis 35g, the bighead atractylodes rhizome 25g, Ligusticum wallichii 25g, cultivated land 30g.
3. the preparation method of Chinese medicine preparation described in any one of claim 1-2, it is characterised in that carried out by the steps:
(1)Traditional vinegar system of pangolin combines modern superfine communication technique:
Traditional vinegar system:Take sand to put in pot, after making popular with high heat, add net pangolin of the same size, stir to heaving, in golden yellow During color, take out, weed out sand, pour into vinegar liquid in time, stir, slightly soak, pull out, dry, crush and use:Supersonic airstream high frequency Vibration ultramicro grinding, crosses 400 mesh sieves standby;
(2)Concentration is slightly considered in remaining herbal medicine immersion boiling:
Chinese medicine another name weight, plus 10 times of amount water immersion 2h, boiling are extracted twice, merge extract solution and be concentrated into 5 times of amounts, and coarse filtration is standby With;
(3)Medicine solid-liquid emulsified mixed suspension is closed in configuration:
Pangolin Ultramicro-powder and Chinese medicine extract are sufficiently mixed tune with sucrose, phosphatide and sodium citrate to scale, are added The emulsifying device that homogenizes carries out emulsification processing;
(4)Quantitative separating:Packing cubing, every bottle of 1500mL;
(5)Quality inspection is encapsulated:Finished product should be well mixed, color and luster consistent, and packaging is using brown sealed polyethylene plastic bag, external application plastic-aluminum Vacuum is self-styled.
4. promote described in claim 1 Chinese medicine preparation of sow lactation improve sow total serum protein, albumin, globulin, Archon than with growth hormone content, improve milking sow lactation power in terms of application.
5. the application described in claim 4, raising sow milk performance therein is referred to:Have to sow good lactagogue, Improve breast matter, improve 0-28 age in days piglet daily gain performances.
CN201710139854.1A 2017-03-10 2017-03-10 It is a kind of to promote Chinese medicine preparation of sow lactation and preparation method and application Pending CN106728339A (en)

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Cited By (1)

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Publication number Priority date Publication date Assignee Title
CN111903612A (en) * 2020-08-29 2020-11-10 沈阳农业大学 Breeding method for northern farming and pasturing staggered donkey

Citations (1)

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Publication number Priority date Publication date Assignee Title
CN103191249A (en) * 2013-04-03 2013-07-10 北京大北农科技集团股份有限公司 Traditional Chinese medicine composition capable of promoting postpartum sow lactation, and applications thereof

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CN103191249A (en) * 2013-04-03 2013-07-10 北京大北农科技集团股份有限公司 Traditional Chinese medicine composition capable of promoting postpartum sow lactation, and applications thereof

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Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111903612A (en) * 2020-08-29 2020-11-10 沈阳农业大学 Breeding method for northern farming and pasturing staggered donkey
CN111903612B (en) * 2020-08-29 2022-05-20 沈阳农业大学 Feeding method for breeding donkey in northern farming-grazing staggered manner

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Application publication date: 20170531