CN106661547B - 调控毛发生长的方法和组合物 - Google Patents

调控毛发生长的方法和组合物 Download PDF

Info

Publication number
CN106661547B
CN106661547B CN201580046441.8A CN201580046441A CN106661547B CN 106661547 B CN106661547 B CN 106661547B CN 201580046441 A CN201580046441 A CN 201580046441A CN 106661547 B CN106661547 B CN 106661547B
Authority
CN
China
Prior art keywords
cells
induced
population
dermal papilla
neural crest
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
CN201580046441.8A
Other languages
English (en)
Chinese (zh)
Other versions
CN106661547A (zh
Inventor
A·V·特尔斯基克
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanford Burnham Prebys Medical Discovery Institute
Original Assignee
Sanford Burnham Prebys Medical Discovery Institute
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanford Burnham Prebys Medical Discovery Institute filed Critical Sanford Burnham Prebys Medical Discovery Institute
Publication of CN106661547A publication Critical patent/CN106661547A/zh
Application granted granted Critical
Publication of CN106661547B publication Critical patent/CN106661547B/zh
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Images

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0625—Epidermal cells, skin cells; Cells of the oral mucosa
    • C12N5/0627—Hair cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/28—Bone marrow; Haematopoietic stem cells; Mesenchymal stem cells of any origin, e.g. adipose-derived stem cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/36—Skin; Hair; Nails; Sebaceous glands; Cerumen; Epidermis; Epithelial cells; Keratinocytes; Langerhans cells; Ectodermal cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/14—Drugs for dermatological disorders for baldness or alopecia
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
    • C12N5/0662—Stem cells
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5044—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics involving specific cell types
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2500/00—Specific components of cell culture medium
    • C12N2500/30—Organic components
    • C12N2500/38—Vitamins
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/11—Epidermal growth factor [EGF]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/115—Basic fibroblast growth factor (bFGF, FGF-2)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
    • C12N2506/02—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from embryonic cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
    • C12N2506/13—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from connective tissue cells, from mesenchymal cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2533/00—Supports or coatings for cell culture, characterised by material
    • C12N2533/30—Synthetic polymers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2533/00—Supports or coatings for cell culture, characterised by material
    • C12N2533/50—Proteins
    • C12N2533/52—Fibronectin; Laminin

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • Cell Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Medicinal Chemistry (AREA)
  • Hematology (AREA)
  • General Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Urology & Nephrology (AREA)
  • Dermatology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Virology (AREA)
  • Rheumatology (AREA)
  • Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Analytical Chemistry (AREA)
  • Toxicology (AREA)
  • Food Science & Technology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • General Physics & Mathematics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
CN201580046441.8A 2014-07-09 2015-07-07 调控毛发生长的方法和组合物 Active CN106661547B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201462022639P 2014-07-09 2014-07-09
US62/022,639 2014-07-09
PCT/US2015/039397 WO2016007522A1 (en) 2014-07-09 2015-07-07 Methods and compositions to modulate hair growth

Publications (2)

Publication Number Publication Date
CN106661547A CN106661547A (zh) 2017-05-10
CN106661547B true CN106661547B (zh) 2021-03-30

Family

ID=55064772

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201580046441.8A Active CN106661547B (zh) 2014-07-09 2015-07-07 调控毛发生长的方法和组合物

Country Status (12)

Country Link
US (2) US10716808B2 (https=)
EP (2) EP4052714A1 (https=)
JP (2) JP6941052B2 (https=)
KR (1) KR102251129B1 (https=)
CN (1) CN106661547B (https=)
AU (2) AU2015287978B2 (https=)
CA (1) CA2954282C (https=)
ES (1) ES2909875T3 (https=)
IL (1) IL249696A0 (https=)
MX (1) MX2017000374A (https=)
SG (2) SG10202111888XA (https=)
WO (1) WO2016007522A1 (https=)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2015287978B2 (en) 2014-07-09 2021-04-29 Sanford-Burnham Medical Research Institute Methods and compositions to modulate hair growth
FR3071512B1 (fr) * 2017-09-28 2022-02-25 Oreal Signatures moleculaires de trois sous-populations de fibroblastes dermiques et equivalent de derme comprenant une de ces sous-populations
CN108324993B (zh) * 2018-01-15 2020-11-03 朱剑虹 一种诱导毛发再生的干细胞复合体、其制备方法及应用
WO2019215557A1 (en) * 2018-05-07 2019-11-14 Reelabs Pvt. Ltd. The method of autologous primary hair follicles preparation in 3d culture
US11468490B2 (en) 2019-01-11 2022-10-11 The Gillette Company Llc Method for providing a customized product recommendation
CN110531057B (zh) * 2019-07-01 2020-11-20 启迪禾美生物科技(嘉兴)有限公司 高通量筛选护肤品用活性组合物的方法
EP4419648A1 (en) * 2021-10-20 2024-08-28 dNovo Inc. Transdifferentiation of non-dermal papilla cells to dermal papilla cells
CN117551600B (zh) * 2024-01-04 2024-04-02 成都云测医学生物技术有限公司 一种促进诱导间充质干细胞分化为真皮乳头细胞的培养基及诱导方法
KR20250174330A (ko) * 2024-06-05 2025-12-12 주식회사 큐스템 모유두 세포 배양액 추출물을 포함하는 두피 모낭 신생 촉진용 조성물

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101755046A (zh) * 2007-07-20 2010-06-23 东国大学校产学协力团 采用间充质干细胞制备真皮乳头组织的方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030161815A1 (en) 2002-02-12 2003-08-28 Intercytex Limited Cell delivery system
GB0605450D0 (en) * 2006-03-17 2006-04-26 Intercytex Ltd Cell co-culture
JP6469655B2 (ja) 2013-05-03 2019-02-13 ザ ヘンリー エム． ジャクソン ファウンデーション フォー ザ アドヴァンスメント オブ ミリタリー メディシン インコーポレイテッド 代用皮膚および毛包新生の方法
JP6304818B2 (ja) * 2014-04-21 2018-04-04 花王株式会社 皮膚由来多能性前駆細胞の作製方法
AU2015287978B2 (en) 2014-07-09 2021-04-29 Sanford-Burnham Medical Research Institute Methods and compositions to modulate hair growth

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101755046A (zh) * 2007-07-20 2010-06-23 东国大学校产学协力团 采用间充质干细胞制备真皮乳头组织的方法

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
Dermal stem cells can differentiate down an endothelial lineage;Bell E等;《Stem Cells Dev》;20121101;第21卷(第16期);第3019-3030页 *
Generation of folliculogenic human epithelial stem cells from induced pluripotent stem cells;Yang R等;《Nat Commun》;20140128(第5期);第1-25页 *
hMSCs possess the potential to differentiate into DP cells in vivo and in vitro;Wu M等;《Cell Biol Int Rep》;20121231;第19卷(第2期);第37-43页 *
Microenvironmental reprogramming by three-dimensional culture enables dermal papilla cells to induce de novo human hair-follicle growth;Higgins CA等;《Proc Natl Acad Sci U S A》;20131203;第110卷(第49期);第19679-19688页 *
Molecular Biology of Hair Morphogenesis：Development and Cycling;VLADIMIR A. BOTCHKAREV等;《JOURNAL OF EXPERIMENTAL ZOOLOGY》;20031231;第298B卷;第164-180页 *
Wu M等.hMSCs possess the potential to differentiate into DP cells in vivo and in vitro.《Cell Biol Int Rep》.2012,第19卷(第2期),第37-43页. *

Also Published As

Publication number Publication date
US11839629B2 (en) 2023-12-12
US20170182095A1 (en) 2017-06-29
US10716808B2 (en) 2020-07-21
SG10202111888XA (en) 2021-11-29
SG11201700095SA (en) 2017-02-27
JP6941052B2 (ja) 2021-09-29
CA2954282C (en) 2023-04-04
IL249696A0 (en) 2017-02-28
AU2021209278B2 (en) 2023-09-07
MX2017000374A (es) 2017-08-25
KR20170020724A (ko) 2017-02-23
EP3167047A4 (en) 2018-04-25
JP2017525672A (ja) 2017-09-07
BR112017000085A2 (pt) 2017-10-31
ES2909875T3 (es) 2022-05-10
AU2015287978A1 (en) 2017-02-02
US20200345772A1 (en) 2020-11-05
CN106661547A (zh) 2017-05-10
EP4052714A1 (en) 2022-09-07
AU2015287978B2 (en) 2021-04-29
CA2954282A1 (en) 2016-01-14
EP3167047B1 (en) 2022-03-09
AU2021209278A1 (en) 2021-08-19
WO2016007522A1 (en) 2016-01-14
EP3167047A1 (en) 2017-05-17
JP2021119202A (ja) 2021-08-12
KR102251129B1 (ko) 2021-05-11

Similar Documents

Publication Publication Date Title
AU2021209278B2 (en) Methods and compositions to modulate hair growth
Yu et al. Isolation of a novel population of multipotent adult stem cells from human hair follicles
Gnedeva et al. Derivation of hair-inducing cell from human pluripotent stem cells
US10344266B2 (en) Cell mass capable of serving as a primitive organ-like structure comprised of a plurality of cell types of somatic origin
US20110165130A1 (en) Methods for Preparing Human Skin Substitutes from Human Pluripotent Stem Cells
SG183097A1 (en) Methods for preparing human melanocytes from human pluripotent stem cells
JP5258213B2 (ja) 体性に由来する複数の細胞種からなる原始的な器官様をなし得る細胞塊
HK40080429A (en) Methods and compositions to modulate hair growth
HK1235430A1 (en) Methods and compositions to modulate hair growth
HK1235430B (en) Methods and compositions to modulate hair growth
BR112017000085B1 (pt) Método para preparação de uma população de células papilares dérmicas induzidas

Legal Events

Date Code Title Description
PB01 Publication
PB01 Publication
SE01 Entry into force of request for substantive examination
SE01 Entry into force of request for substantive examination
GR01 Patent grant
GR01 Patent grant