CN106620069A - Medicinal composition for treating skin allergy caused by insect bites and stings and preparation method of medicinal composition - Google Patents
Medicinal composition for treating skin allergy caused by insect bites and stings and preparation method of medicinal composition Download PDFInfo
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- CN106620069A CN106620069A CN201710143091.8A CN201710143091A CN106620069A CN 106620069 A CN106620069 A CN 106620069A CN 201710143091 A CN201710143091 A CN 201710143091A CN 106620069 A CN106620069 A CN 106620069A
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Abstract
The invention relates to the field of traditional Chinese medicines, and in particular relates to a medicinal composition for treating skin allergy caused by insect bites and stings and a preparation method of the medicinal composition. The medicinal composition is prepared from the following raw materials in parts by weight: 10-18 parts of dilleniad extract, 6-12 parts of amur barberry root and branchlet extract, 10-15 parts of magnolia figo flowers, 5-10 parts of all-grass of Hemigraphis procumbens (Lour.) Merr., 4-12 parts of folium cycas, 3-10 parts of beewax, 3-12 parts of herba speranskiae tuberculatae, 5-10 parts of flos jasmini grandiflori immaturus, 6-12 parts of folium et caulis indigoferae tinctoriae, 3-8 parts of radix notoginseng, 3-8 parts of borneol, 3-8 parts of pomegranate bark, 4-9 parts of castor beans, 6-12 parts of herba scutellariae barbatae, 3-6 parts of cortex phellodendri, 4-7 parts of herba commelinae, 3-5 parts of herba menthae, and 1-10 parts of licorice root. The medicinal composition has the obvious curative effects for skin allergy caused by insect bites and stings, has the efficacies of reinforcing qi and nourishing blood and clearing heat and promoting diuresis, and is mild in drug property, free of side effects, and suitable for the vast common patients.
Description
Technical field
The present invention relates to the field of Chinese medicines, especially, is related to a kind of for medicine group allergic caused by mosquito bite and insect bite
Compound and preparation method thereof.
Background technology
Allergic caused by mosquito bite and insect bite is the mistake caused due to the venom of insect or the metabolin contact skin of polypide
Quick reaction, patient can feel acute pruritus, sometimes pimpling, the papulo-vesicle even pain of bulla and accompanied by intense.And mosquito
The venom or metabolin of worm enters human body often through biting, if process to be also possible to that serious consequence can be caused not in time, very
To harmful to human safety.It is usually to be used for using Western medicine for method allergic caused by mosquito bite and insect bite, but Western medicine pair
Effect is larger and excitant is larger, less suitable to some crowds, such as infant；Conditioning radical cure is carried out more from inherence using Chinese medicine
Meet the demand of people.But great majority are to cause allergic Chinese medicine for a variety of causes on market, and specific aim is not strong, and
It is much to play a part of alleviation, eliminating symptom and discomfort needs longer time, additionally, in antalgesic-antipruritic and subdhing swelling and detoxicating side
Face effect is not very notable.
The content of the invention
It is not strong in order to solve specific aim present in prior art, the problems such as drug effect is not very notable, the invention provides
It is a kind of for pharmaceutical composition allergic caused by mosquito bite and insect bite and preparation method thereof, the pharmaceutical composition is being stung for mosquito
Allergic aspect has significant curative effect caused by insect bite, moreover it is possible to nourishing qi and blood, clearing heat and promoting diuresis, and the property of medicine is gentle, without pair
Effect, it is adaptable to vast masses patient.Additionally, the present invention also provides a kind of method for preparing the pharmaceutical composition.
It is of the present invention for pharmaceutical composition allergic caused by mosquito bite and insect bite by following parts by weight original
Material is prepared from：
Dilleniad extract 10-18 parts, barberry extract 6-12 parts, Michelia figo 10-15 parts, attached column flower 5-10 parts, folium cycas 4-
12 parts, beeswax 3-10 parts, lopseed 3-12 parts, jasmine 5-10 parts, wooden indigo plant 6-12 parts, pseudo-ginseng 3-8 parts, borneol 3-8 parts, pomegranate
Skin 3-8 parts, castor bean 4-9 parts, Sculellaria barbata 6-12 parts, golden cypress 3-6 parts, dayflower 4-7 parts, peppermint 3-5 parts and Radix Glycyrrhizae 1-10 parts.
It is preferred that the formula for going out 3 pharmaceutical compositions is：
1st, 10 parts of dilleniad extract, 6 parts of barberry extract, 10 parts of Michelia figo, attached column spend 5 parts, folium cycas 4- parts, 3 parts of beeswax,
3 parts of lopseed, 5 parts of jasmine, 6 parts of wood indigo plant, 3 parts of pseudo-ginseng, 3 parts of borneol, 3 parts of granatum, 4 parts of castor bean, 6 parts of Sculellaria barbata, Huang
1 part of 3 parts of cypress, 4 parts of dayflower, 3 parts of peppermint and Radix Glycyrrhizae.
2nd, 18 parts of dilleniad extract, 12 parts of barberry extract, 15 parts of Michelia figo, attached column spend 10 parts, 12 parts of folium cycas, honeybee
10 parts of wax, 12 parts of lopseed, 10 parts of jasmine, wood are blue 12 parts, 8 parts of pseudo-ginseng, 8 parts of borneol, 8 parts of granatum, 9 parts of castor bean, half
10 parts of 12 parts of lotus of branch, 6 parts of golden cypress, 7 parts of dayflower, 5 parts of peppermint and Radix Glycyrrhizae.
3rd, 14 parts of dilleniad extract, 9 parts of barberry extract, 12 parts of Michelia figo, attached column spend 8 parts, 8 parts of folium cycas, beeswax 6
Part, 8 parts of lopseed, 8 parts of jasmine, blue 9 parts wood, 6 parts of pseudo-ginseng, 6 parts of borneol, 6 parts of granatum, 7 parts of castor bean, 9 parts of Sculellaria barbata,
5 parts of 5 parts of golden cypress, 6 parts of dayflower, 4 parts of peppermint and Radix Glycyrrhizae.
Preferably, described pharmaceutical composition is made into oral formulations and external preparation.
Preferably, the oral formulations are powder, tablet and granule.
Preferably, the external preparation is cream and ointment.
Preferably, the preparation method of the dilleniad extract includes following step：Dilleniad root summer, autumn excavation, bark
Spring, summer, autumn strip, and dry standby, weigh the root and skin of dilleniad, smash to pieces, add the distilled water of 4-6 times of initial weight,
Subsequently immersion 30-40min, backflow decoction 1-2 time, return time is 1-2h, is filtered, and obtains filtrate, drying under reduced pressure, mistake after crushing
80-100 mesh sieves, obtain final product dilleniad extract.
Preferably, the preparation method of the barberry extract includes following step：Barberry rhizome spring, autumn excavation, clean
Dry, it is standby, barberry rhizome is weighed, smash to pieces, the distilled water of 4-6 times of initial weight is added, 30-40min is subsequently soaked, backflow is decocted
Boil 1-2 time, return time is 1-2h, filter, obtain filtrate, drying under reduced pressure crosses 80-100 mesh sieves, obtains final product barberry extraction after crushing
Thing.
Accordingly, the preparation method of pharmaceutical composition of the present invention includes following step：
1）Michelia figo, attached column flower, jasmine, lopseed, wood indigo plant, granatum and dayflower are weighed, is crushed, be well mixed, it is standby；
2）Toward step 1）Traditional Chinese medicine powder adds the ethanol solution that medicinal powder weight 3-5 times concentration is 50%-60%, refluxing extraction 1-3 time to return
The stream time be 2-3h, merging filtrate, retain filter residue, filtrate recycling ethanol, being evaporated to relative density under 65-75 DEG C of environment is
The medicinal extract of 1.20-1.25, drying under reduced pressure crosses 80-100 mesh sieves after crushing, obtain medicinal extract fine powder；
3）Folium cycas, pseudo-ginseng, castor bean, Sculellaria barbata, golden cypress, peppermint and Radix Glycyrrhizae are weighed, is crushed, be well mixed, it is standby；
4）Take step 3）Traditional Chinese medicine powder, adds step 2）In filter residue, mixing obtains mixture, adds mixture weight 4-6 times
Distilled water, soaks 1-2 hours, and backflow decocts 2-3 hours, filters, and adds the distilled water of mixture weight 2-3 times, and backflow is decocted
1-1..5 hours are boiled, are filtered, merging filtrate, be evaporated to the medicinal extract that relative density under 65-75 DEG C of environment is 1.20-1.25,
Drying under reduced pressure, crosses 80-100 mesh sieves after crushing, obtain medicinal extract fine powder；
5）Borneol and beeswax are ground into into fine powder, 80-100 mesh sieves are crossed, it is standby；
6）By dilleniad extract, barberry extract and step 2）Middle medicinal extract fine powder and step 4）Middle medicinal extract fine powder and step 5）
Middle fine powder mixing, stirs, and obtains final product pharmaceutical composition of the present invention.
Dilleniad：Yunnan Province is distributed mainly on, is root, the skin of Dilleniaceae plant dilleniad；For hemostasis swelling, skin
Skin redness, nameless sores or boils, ulcer sores, worm snake bite, dysentery, enteritis, rotavirus enteritis, taste is sour, puckery, puts down；The thoughts of returning home, large intestine two
Jing；Also there is removing toxic substances, it is allergic with effective radical cure effect for caused by mosquito bite and insect bite；Bark fat containing white birch
Aldehyde, betulin, lupeol, cupreol, betulic acid, myricetin, the β of 3 beta-hydroxy lupane -13,28 lactones disappear
Rotation dihydro Isorhamnetin, Kaempferol glycoside and quercetin derivative etc..
Barberry：Barberry potted plant can be viewed and admired, and be to plant flower hedge, intersperse the good material of mountain stone, and barberry branch is close, attitude rounding, the spring
Open chrysanthemum, autumn knot haw, late autumn leaf color is purplish red, and the fruit Jing winters do not fall, be all good ornamencal flower and tree of flower, fruit, leaf；Fruit branch can be inserted
Bottle, root, stem are used as medicine, and rhizome is used as medicine and can be generally used for controlling chordapsus, dysentery with heat-clearing and damp-drying drug, purging intense heat and detonicating, anti-inflammation
Deng, but clinical tests prove that, for allergic with good curative effect caused by mosquito bite and insect bite.
Michelia figo：Containing abundant nutrient content, bioactive ingredients and natural plant essence, mood can be not only made one
Please, inspire enthusiasm, also there is promoting blood circulation for regulating menstruation, foster skin beauty treatment, decompression of calming the nerves, fibre body body beautification, health body-building and eliminate disease and prolong life
Magical effect, in addition to the effect for possessing general natural plants flowers and plants, moreover it is possible to removing pattogenic heat from the blood and toxic material from the body, containing diuresis composition, can promote
The discharge of vivotoxin, improves metabolism, for the symptom such as allergic can effectively be alleviated.
Attached column is spent：For the herb of acanthaceous plant attached column flower, summer, autumn harvesting, clean, using fresh herb cheekbone is dried, mildly bitter flavor,
It is pungent, it is cool in nature；With clearing heat and detoxicating；Removing dampness through diuresis and relieving itching；Effect of swelling and pain relieving, for caterpillar has stabbed significant curative effect.
Folium cycas：The leaf of dicotyledon medicine Agavaceae ti；It is sweet, light, it is cool in nature；With heat-clearing, effect of hemostasis,
For the symptom that the allergic congested or patient scratching for causing causes bleeding to cause has mitigation.
Beeswax：The product are the wax that apidae insect apis cerana or apis mellifera Linnaeus are secreted, and honeycomb is put in water and is heated, filter
Cross, condensation takes wax or re-refines and forms；Its Main Ingredients and Appearance has:Acids, free fatty, free alkyl alcohol and carbohydrate,
Additionally, also carotenoid, vitamin A, aromatic substance etc., with inducing astrigency, sore, myogenic, pain relieving, the effect of conditioning, also have
Have harmonizing yingfen and weifen, a nourishing qi and blood, wind-dispelling moisturize and blood removing toxic substances efficiency.
Lopseed：It is bitter, pungent, it is warm in nature；With invigorate blood circulation, wind-expelling pain-stopping, effect of external application removing toxic substances.
Jasmine：Hardship, puts down, nontoxic；Can be used for skin sufferings, originate in Yunnan, Sichuan, Tibet and Himalaya Region.
It is wooden blue：For the blue leaf of dicotyledon medicine legume wood and stem；Hardship, trembles with fear；It is distributed in Shandong, Jiangsu, Fujian, platform
The ground such as gulf, Guangdong, Guangxi, Hubei, Sichuan, Yunnan, summer, autumn harvesting, leaf energy removing pattogenic heat from the blood and toxic material from the body, purging intense heat dissipate strongly fragrant；Root and cauline leaf external application,
Pyogenic infections can be controlled, root can solve worm poison.
Pseudo-ginseng：The effect of with detumescence ding-tong.
Granatum：Taste is sour, puckery, warm in nature；Can be with relieving iching by astringing, desinsection removing toxic substances.
Castor bean：Swell and ache with dissipation, effect of pain relieving myogenic.
Sculellaria barbata：Sun plant all herbal medicine, it is cold in nature with functions such as clearing heat and detoxicating, promoting blood circulation, swelling and pain relieving, anticancers
Taste acid, herb has removing pattogenic heat from the blood and toxic material from the body, blood stasis removing analgesic, detumescence and heat-clearing profit containing compositions such as multivitamin, trace element and amino acid
Wet the effect of.
The invention has the advantages that：
1st, using the comparatively gentle herbaceous plant of the property of medicine and Chinese medicine, most of herbaceous plant can for pharmaceutical composition of the present invention
Be used as medicine and can play a part of to view and admire, between each composition of inventive formulation collaboration is played a part of, can nourishing qi and blood, heat-clearing profit
Wet, allergic aspect also has significant curative effect caused by for mosquito bite and insect bite, can at short notice reach detumescence and stop
Bitterly, effect of anti-itch detoxification, can effectively eliminate the harm that the venom or metabolin of mosquito bite and insect bite are produced to human body, while reaching again
Conditioning and the effect treated；Additionally, also using the composition of myogenic foster skin beauty treatment so that the skin after allergic is quickly recovered to
Delicate state；
2nd, pharmaceutical composition of the present invention is with strong points, especially for allergic evident in efficacy caused by mosquito bite and insect bite, and fits
For vast masses patient, additionally, the medicine use it is also very convenient, both can orally can be with external application, can be according to not
Same requirement is used；
3rd, by clinical trial, pharmaceutical composition of the present invention is made after the formulation of various oral and external applications is taken to patient and is used
In effect is significant, cure rate is higher, it is seen then that pharmaceutical composition of the present invention can be used as allergic caused by mosquito bite and insect bite
Medicine use, clinical value is higher.
In addition to objects, features and advantages described above, the present invention also has other objects, features and advantages.
Below the present invention is further detailed explanation.
Specific embodiment
Embodiments of the invention are described in detail below, but the present invention can be limited according to claim and covered
Multitude of different ways implement.
Embodiment 1：Powder
The preparing raw material of the pharmaceutical composition of the embodiment of the present invention 1 includes：10 parts of dilleniad extract, 6 parts of barberry extract, with a smile
Spend 10 parts, attached column spend 5 parts, folium cycas 4- parts, 3 parts of beeswax, 3 parts of lopseed, 5 parts of jasmine, blue 6 parts wood, 3 parts of pseudo-ginseng, borneol 3
1 part of part, 3 parts of granatum, 4 parts of castor bean, 6 parts of Sculellaria barbata, 3 parts of golden cypress, 4 parts of dayflower, 3 parts of peppermint and Radix Glycyrrhizae.
Preparation method is as follows：
Prepare dilleniad extract：Dilleniad root summer, autumn excavation, bark spring, summer, autumn strip, and dry standby, weigh five forks
The root and skin of fruit, smashs to pieces, adds the distilled water of 4-6 times of initial weight, subsequently soaks 35min, and backflow is decocted 1 time, return time
For 2h, filter, obtain filtrate, drying under reduced pressure crosses 100 mesh sieves, obtains final product dilleniad extract after crushing；
Prepare barberry extract：Barberry rhizome spring, autumn excavation, clean and dry, standby, weigh barberry rhizome, smash to pieces, add just
The distilled water that 6 times of starting weight amount, subsequently soaks 40min, and backflow is decocted 2 times, and return time is 2h, is filtered, and obtains filtrate, and decompression is dry
It is dry, 100 mesh sieves are crossed after crushing, obtain final product barberry extract；
3）Michelia figo, attached column flower, jasmine, lopseed, wood indigo plant, granatum and dayflower are weighed, is crushed, be well mixed, it is standby；
4）Toward step 3）Traditional Chinese medicine powder adds the ethanol solution that medicinal powder 4 times of concentration of weight are 60%, refluxing extraction 2 times, and return time is
2h, merging filtrate retains filter residue, and filtrate recycling ethanol is evaporated to the medicinal extract that relative density under 70 DEG C of environment is 1.25, subtracts
Pressure crosses 100 mesh sieves after dry, pulverize, and obtains medicinal extract fine powder；
5）Folium cycas, pseudo-ginseng, castor bean, Sculellaria barbata, golden cypress, peppermint and Radix Glycyrrhizae are weighed, is crushed, be well mixed, it is standby；
6）Take step 5）Traditional Chinese medicine powder, adds step 4）In filter residue, mixing obtains mixture, adds the steaming of 5 times of mixture weight
Distilled water, soaks 1 hour, and backflow is decocted 3 hours, filters, and adds the distilled water of 3 times of mixture weight, and backflow is decocted 1 hour,
Filter, merging filtrate, be evaporated to the medicinal extract that relative density under 70 DEG C of environment is 1.25, drying under reduced pressure crosses 100 mesh after crushing
Sieve, obtains medicinal extract fine powder；
7）Borneol and beeswax are ground into into fine powder, 100 mesh sieves are crossed, it is standby；
8）By dilleniad extract, barberry extract and step 4）Middle medicinal extract fine powder and step 6）Middle medicinal extract fine powder and step 7）
Middle fine powder mixing, stirs, and obtains final product pharmaceutical composition of the present invention；
9）Diluent lactose is added by equivalent method of progressively increasing, the amount ratio of fine powder and diluent is 1:100, obtain 100 times and dissipate, cross six
Number sieve, obtain loose powder, carry out quality inspection, Jing after quality inspection is qualified, packaging, obtain final product the medicinal composition powders of the embodiment of the present invention 1.
Embodiment 2：Powder
The preparing raw material of the pharmaceutical composition of the embodiment of the present invention 2 includes：18 parts of dilleniad extract, 12 parts of barberry extract, contain
Laugh at spend 15 parts, attached column spend 10 parts, 12 parts of folium cycas, 10 parts of beeswax, 12 parts of lopseed, 10 parts of jasmine, wood indigo plant 12 parts, pseudo-ginseng 8
Part, 8 parts of borneol, 8 parts of granatum, 9 parts of castor bean, 12 parts of Sculellaria barbata, 6 parts of golden cypress, 7 parts of dayflower, 5 parts of peppermint and Radix Glycyrrhizae 10
Part.
Preparation method is with embodiment 1.
Embodiment 3：Powder
The preparing raw material of the pharmaceutical composition of the embodiment of the present invention 3 includes：14 parts of dilleniad extract, 9 parts of barberry extract, with a smile
Spend 12 parts, attached column spend 8 parts, 8 parts of folium cycas, 6 parts of beeswax, 8 parts of lopseed, 8 parts of jasmine, blue 9 parts wood, 6 parts of pseudo-ginseng, borneol 6
5 parts of part, 6 parts of granatum, 7 parts of castor bean, 9 parts of Sculellaria barbata, 5 parts of golden cypress, 6 parts of dayflower, 4 parts of peppermint and Radix Glycyrrhizae.
Preparation method is with embodiment 1.
Embodiment 4：Granule
The preparing raw material of the pharmaceutical composition of the embodiment of the present invention 4 includes：10 parts of dilleniad extract, 6 parts of barberry extract, with a smile
Spend 10 parts, attached column spend 5 parts, folium cycas 4- parts, 3 parts of beeswax, 3 parts of lopseed, 5 parts of jasmine, blue 6 parts wood, 3 parts of pseudo-ginseng, borneol 3
1 part of part, 3 parts of granatum, 4 parts of castor bean, 6 parts of Sculellaria barbata, 3 parts of golden cypress, 4 parts of dayflower, 3 parts of peppermint and Radix Glycyrrhizae.
Preparation method is as follows：
1）Prepare dilleniad extract：Dilleniad root summer, autumn excavation, bark spring, summer, autumn strip, and dry standby, weigh five
The root and skin of fork fruit, smashs to pieces, adds the distilled water of 6 times of initial weight, subsequently soaks 30min, and backflow is decocted 2 times, return time
For 2h, filter, obtain filtrate, drying under reduced pressure crosses 80 mesh sieves, obtains final product dilleniad extract after crushing；
2）Prepare barberry extract：Barberry rhizome spring, autumn excavation, clean and dry, standby, weigh barberry rhizome, smash to pieces, add
The distilled water that 6 times of initial weight, subsequently soaks 40min, and backflow is decocted 2 times, and return time is 2h, is filtered, and obtains filtrate, is reduced pressure
80 mesh sieves are crossed after dry, pulverize, barberry extract is obtained final product；
3）Michelia figo, attached column flower, jasmine, lopseed, wood indigo plant, granatum and dayflower are weighed, is crushed, be well mixed, it is standby；
4）Toward step 3）Traditional Chinese medicine powder adds the ethanol solution that medicinal powder 4 times of concentration of weight are 60%, refluxing extraction 2 times, and return time is
2h, merging filtrate retains filter residue, and filtrate recycling ethanol is evaporated to the medicinal extract that relative density under 70 DEG C of environment is 1.25, subtracts
Pressure crosses 80 mesh sieves after dry, pulverize, and obtains medicinal extract fine powder；
5）Folium cycas, pseudo-ginseng, castor bean, Sculellaria barbata, golden cypress, peppermint and Radix Glycyrrhizae are weighed, is crushed, be well mixed, it is standby；
6）Take step 5）Traditional Chinese medicine powder, adds step 4）In filter residue, mixing obtains mixture, adds the steaming of 5 times of mixture weight
Distilled water, soaks 1 hour, and backflow is decocted 3 hours, filters, and adds the distilled water of 3 times of mixture weight, and backflow is decocted 1 hour,
Filter, merging filtrate, be evaporated to the medicinal extract that relative density under 70 DEG C of environment is 1.25, drying under reduced pressure crosses 80 mesh after crushing
Sieve, obtains medicinal extract fine powder；
7）Borneol and beeswax are ground into into fine powder, 80 mesh sieves are crossed, it is standby；
8）By dilleniad extract, barberry extract and step 4）Middle medicinal extract fine powder and step 6）Middle medicinal extract fine powder and step 7）
Middle fine powder mixing, stirs, and obtains final product pharmaceutical composition of the present invention；
9）1 part of above-mentioned fine powder is taken, 3 parts of cane sugar powder, 1.5 parts of dextrin and appropriate amount of ethanol, softwood processed is crossed the pelleting of 16 mesh sieves, is dried,
Obtain final product the medicament composition granule agent of the embodiment of the present invention 4.
Embodiment 5：Granule
The preparing raw material of the pharmaceutical composition of the embodiment of the present invention 5 includes：18 parts of dilleniad extract, 12 parts of barberry extract, contain
Laugh at spend 15 parts, attached column spend 10 parts, 12 parts of folium cycas, 10 parts of beeswax, 12 parts of lopseed, 10 parts of jasmine, wood indigo plant 12 parts, pseudo-ginseng 8
Part, 8 parts of borneol, 8 parts of granatum, 9 parts of castor bean, 12 parts of Sculellaria barbata, 6 parts of golden cypress, 7 parts of dayflower, 5 parts of peppermint and Radix Glycyrrhizae 10
Part.
Preparation method is with embodiment 4.
Embodiment 6：Granule
The preparing raw material of the pharmaceutical composition of the embodiment of the present invention 6 includes：14 parts of dilleniad extract, 9 parts of barberry extract, with a smile
Spend 12 parts, attached column spend 8 parts, 8 parts of folium cycas, 6 parts of beeswax, 8 parts of lopseed, 8 parts of jasmine, blue 9 parts wood, 6 parts of pseudo-ginseng, borneol 6
5 parts of part, 6 parts of granatum, 7 parts of castor bean, 9 parts of Sculellaria barbata, 5 parts of golden cypress, 6 parts of dayflower, 4 parts of peppermint and Radix Glycyrrhizae.
Preparation method is with embodiment 4.
Embodiment 7：Cream
The preparing raw material of the pharmaceutical composition of the embodiment of the present invention 7 includes：10 parts of dilleniad extract, 6 parts of barberry extract, with a smile
Spend 10 parts, attached column spend 5 parts, folium cycas 4- parts, 3 parts of beeswax, 3 parts of lopseed, 5 parts of jasmine, blue 6 parts wood, 3 parts of pseudo-ginseng, borneol 3
1 part of part, 3 parts of granatum, 4 parts of castor bean, 6 parts of Sculellaria barbata, 3 parts of golden cypress, 4 parts of dayflower, 3 parts of peppermint and Radix Glycyrrhizae.
Preparation method is as follows：
1）Prepare dilleniad extract：Dilleniad root summer, autumn excavation, bark spring, summer, autumn strip, and dry standby, weigh five
The root and skin of fork fruit, smashs to pieces, adds the distilled water of 6 times of initial weight, subsequently soaks 30min, and backflow is decocted 2 times, return time
For 2h, filter, obtain filtrate, drying under reduced pressure crosses 80 mesh sieves, obtains final product dilleniad extract after crushing；
2）Prepare barberry extract：Barberry rhizome spring, autumn excavation, clean and dry, standby, weigh barberry rhizome, smash to pieces, add
The distilled water that 6 times of initial weight, subsequently soaks 40min, and backflow is decocted 2 times, and return time is 2h, is filtered, and obtains filtrate, is reduced pressure
80 mesh sieves are crossed after dry, pulverize, barberry extract is obtained final product；
3）Michelia figo, attached column flower, jasmine, lopseed, wood indigo plant, granatum and dayflower are weighed, is crushed, be well mixed, it is standby；
4）Toward step 3）Traditional Chinese medicine powder adds the ethanol solution that medicinal powder 4 times of concentration of weight are 60%, refluxing extraction 2 times, and return time is
2h, merging filtrate retains filter residue, and filtrate recycling ethanol is evaporated to the medicinal extract that relative density under 70 DEG C of environment is 1.25, subtracts
Pressure crosses 80 mesh sieves after dry, pulverize, and obtains medicinal extract fine powder；
5）Folium cycas, pseudo-ginseng, castor bean, Sculellaria barbata, golden cypress, peppermint and Radix Glycyrrhizae are weighed, is crushed, be well mixed, it is standby；
6）Take step 5）Traditional Chinese medicine powder, adds step 4）In filter residue, mixing obtains mixture, adds the steaming of 5 times of mixture weight
Distilled water, soaks 1 hour, and backflow is decocted 3 hours, filters, and adds the distilled water of 3 times of mixture weight, and backflow is decocted 1 hour,
Filter, merging filtrate, be evaporated to the medicinal extract that relative density under 70 DEG C of environment is 1.25, drying under reduced pressure crosses 80 mesh after crushing
Sieve, obtains medicinal extract fine powder；
7）Borneol and beeswax are ground into into fine powder, 80 mesh sieves are crossed, it is standby；
8）By dilleniad extract, barberry extract and step 4）Middle medicinal extract fine powder and step 6）Middle medicinal extract fine powder and step 7）
Middle fine powder mixing, stirs, and obtains final product pharmaceutical composition of the present invention；
9）By fine drug powder of the present invention and emulsified bases 1:4 proportional arrangement is into cream.
Embodiment 8：Cream
The preparing raw material of the pharmaceutical composition of the embodiment of the present invention 8 includes：18 parts of dilleniad extract, 12 parts of barberry extract, contain
Laugh at spend 15 parts, attached column spend 10 parts, 12 parts of folium cycas, 10 parts of beeswax, 12 parts of lopseed, 10 parts of jasmine, wood indigo plant 12 parts, pseudo-ginseng 8
Part, 8 parts of borneol, 8 parts of granatum, 9 parts of castor bean, 12 parts of Sculellaria barbata, 6 parts of golden cypress, 7 parts of dayflower, 5 parts of peppermint and Radix Glycyrrhizae 10
Part.
Preparation method is with embodiment 7.
Embodiment 9：Cream
The preparing raw material of the pharmaceutical composition of the embodiment of the present invention 9 includes：14 parts of dilleniad extract, 9 parts of barberry extract, with a smile
Spend 12 parts, attached column spend 8 parts, 8 parts of folium cycas, 6 parts of beeswax, 8 parts of lopseed, 8 parts of jasmine, blue 9 parts wood, 6 parts of pseudo-ginseng, borneol 6
5 parts of part, 6 parts of granatum, 7 parts of castor bean, 9 parts of Sculellaria barbata, 5 parts of golden cypress, 6 parts of dayflower, 4 parts of peppermint and Radix Glycyrrhizae.
Preparation method is with embodiment 7.
Embodiment 10：Clinical testing
1st, physical data
Clinical observation is by allergic patient caused by mosquito bite and insect bite, and observation index is as follows：There is red or white papule in skin,
It is rubescent to itch, swelling tertia, situations such as water outlet.Clinical testing patient's list is included Jing after patient agrees to, totally 40.By patient with
Machine is divided into 4 groups, per group each 10, the influence factor such as two groups of ages, state of an illness distributions, is statistically analyzed, poor without conspicuousness
It is different, meet packet condition.
2nd, trial drug and test method
A groups：Medicinal composition powders of the present invention prepared by the oral embodiment of the present invention 1, each 10g daily 2 times, serve on 5 days；
B groups：Medicament composition granule agent of the present invention prepared by the oral embodiment of the present invention 4, each 10g daily 2 times, serve on 5
My god；
C groups：Smear the embodiment of the present invention 7 preparation pharmaceutical composition cream of the present invention, each uniform application on wound, often
It 2 times, it serve on 5 days；
Control group：The antipruritic antibacterial cream of hundred grass is smeared, each uniform application daily 2 times, serve on 5 days on wound.
3rd, standard is treated：
Subjective symptom：Scorching hot, itch, pain is dried, furfur and tension；
Objective sign：Marjoram Extract, erythema or flush, oedema, papule useless fellow or pigmentation or atrophoderma.
4th, efficacy determination：
1）Cure：Papule all disappears, and itches without distending pain pain, and skin colour recovers normal；
2）Effectively：Papule is reduced or disappeared, and mitigation of itching is ached in swelling, and skin colour thickness has improvement；
3）It is invalid：Without improving or increase before and after treatment.
5th, treatment results, as shown in table 1
The treatment results of table 1
| Group | Number | Cure（Rate） | Effectively | Do not heal |
| A groups | 10 | 10（100%） | 0 | 0 |
| B groups | 10 | 10（100%） | 0 | 0 |
| C groups | 10 | 10（100%） | 0 | 0 |
| Control group | 10 | 4（40%） | 2 | 4 |
5th, conclusion (of pressure testing)
Clinical testing data shows that pharmaceutical composition of the present invention is used for effect is significant allergic caused by mosquito bite and insect bite, controls
More rate is up to 100%, hence it is evident that higher than control group.Clinical testing proves that pharmaceutical composition of the present invention is used for skin caused by mosquito bite and insect bite
Allergy is rapid-action, effect is significant, can use as medicine allergic caused by mosquito bite and insect bite is used for, clinical generalization value
It is high.
The preferred embodiments of the present invention are the foregoing is only, the present invention is not limited to, for the skill of this area
For art personnel, the present invention can have various modifications and variations.It is all within the spirit and principles in the present invention, made any repair
Change, equivalent, improvement etc., should be included within the scope of the present invention.
Claims (10)
1. be used for allergic pharmaceutical composition caused by mosquito bite and insect bite, it is characterised in that described pharmaceutical composition by with
The raw material of lower parts by weight is prepared from：
Dilleniad extract 10-18 parts, barberry extract 6-12 parts, Michelia figo 10-15 parts, attached column flower 5-10 parts, folium cycas 4-
12 parts, beeswax 3-10 parts, lopseed 3-12 parts, jasmine 5-10 parts, wooden indigo plant 6-12 parts, pseudo-ginseng 3-8 parts, borneol 3-8 parts, pomegranate
Skin 3-8 parts, castor bean 4-9 parts, Sculellaria barbata 6-12 parts, golden cypress 3-6 parts, dayflower 4-7 parts, peppermint 3-5 parts and Radix Glycyrrhizae 1-10 parts.
2. it is according to claim 1 for pharmaceutical composition allergic caused by mosquito bite and insect bite, it is characterised in that institute
The pharmaceutical composition stated is prepared from by the raw material of following parts by weight：
10 parts of dilleniad extract, 6 parts of barberry extract, 10 parts of Michelia figo, attached column spend 5 parts, folium cycas 4- parts, 3 parts of beeswax, thoroughly
3 parts of bone grass, 5 parts of jasmine, 6 parts of wood indigo plant, 3 parts of pseudo-ginseng, 3 parts of borneol, 3 parts of granatum, 4 parts of castor bean, 6 parts of Sculellaria barbata, golden cypress 3
1 part of part, 4 parts of dayflower, 3 parts of peppermint and Radix Glycyrrhizae.
3. it is according to claim 1 for pharmaceutical composition allergic caused by mosquito bite and insect bite, it is characterised in that institute
The pharmaceutical composition stated is prepared from by the raw material of following parts by weight：
18 parts of dilleniad extract, 12 parts of barberry extract, 15 parts of Michelia figo, attached column spend 10 parts, 12 parts of folium cycas, beeswax 10
Part, 12 parts of lopseed, 10 parts of jasmine, blue 12 parts wood, 8 parts of pseudo-ginseng, 8 parts of borneol, 8 parts of granatum, 9 parts of castor bean, Sculellaria barbata
10 parts of 12 parts, 6 parts of golden cypress, 7 parts of dayflower, 5 parts of peppermint and Radix Glycyrrhizae.
4. it is according to claim 1 for pharmaceutical composition allergic caused by mosquito bite and insect bite, it is characterised in that institute
The pharmaceutical composition stated is prepared from by the raw material of following parts by weight：
14 parts of dilleniad extract, 9 parts of barberry extract, 12 parts of Michelia figo, attached column spend 8 parts, 8 parts of folium cycas, 6 parts of beeswax, thoroughly
8 parts of bone grass, 8 parts of jasmine, 9 parts of wood indigo plant, 6 parts of pseudo-ginseng, 6 parts of borneol, 6 parts of granatum, 7 parts of castor bean, 9 parts of Sculellaria barbata, golden cypress 5
5 parts of part, 6 parts of dayflower, 4 parts of peppermint and Radix Glycyrrhizae.
5. it is according to claim 1 for pharmaceutical composition allergic caused by mosquito bite and insect bite, it is characterised in that institute
State pharmaceutical composition and be made into oral formulations and external preparation.
6. it is according to claim 5 for pharmaceutical composition allergic caused by mosquito bite and insect bite, it is characterised in that institute
Oral formulations are stated for powder, tablet and granule.
7. it is according to claim 5 for pharmaceutical composition allergic caused by mosquito bite and insect bite, it is characterised in that institute
External preparation is stated for cream and ointment.
8. it is according to claim 1 for pharmaceutical composition allergic caused by mosquito bite and insect bite, it is characterised in that institute
The preparation method for stating dilleniad extract includes following step：Dilleniad root summer, autumn excavation, bark spring, summer, autumn strip,
Dry standby, weigh the root and skin of dilleniad, smash to pieces, add the distilled water of 4-6 times of initial weight, subsequently soak 30-40min,
Backflow is decocted 1-2 time, and return time is 1-2h, is filtered, and obtains filtrate, and drying under reduced pressure crosses 80-100 mesh sieves, obtains final product five after crushing
Fork berry extract.
9. it is according to claim 1 for pharmaceutical composition allergic caused by mosquito bite and insect bite, it is characterised in that institute
The preparation method for stating barberry extract includes following step：Barberry rhizome spring, autumn excavation, clean and dry, standby, weigh barberry
Rhizome, smashs to pieces, adds the distilled water of 4-6 times of initial weight, subsequently soaks 30-40min, and backflow is decocted 1-2 time, and return time is
1-2h, filters, and obtains filtrate, and drying under reduced pressure crosses 80-100 mesh sieves, obtains final product barberry extract after crushing.
10. according to the arbitrary described preparation for pharmaceutical composition allergic caused by mosquito bite and insect bite of claim 1-9
Method, it is characterised in that the preparation method of described pharmaceutical composition includes following step：
1）Michelia figo, attached column flower, jasmine, lopseed, wood indigo plant, granatum and dayflower are weighed, is crushed, be well mixed, it is standby；
2）Toward step 1）Traditional Chinese medicine powder adds the ethanol solution that medicinal powder weight 3-5 times concentration is 50%-60%, refluxing extraction 1-3 time to return
The stream time be 2-3h, merging filtrate, retain filter residue, filtrate recycling ethanol, being evaporated to relative density under 65-75 DEG C of environment is
The medicinal extract of 1.20-1.25, drying under reduced pressure crosses 80-100 mesh sieves after crushing, obtain medicinal extract fine powder；
3）Folium cycas, pseudo-ginseng, castor bean, Sculellaria barbata, golden cypress, peppermint and Radix Glycyrrhizae are weighed, is crushed, be well mixed, it is standby；
4）Take step 3）Traditional Chinese medicine powder, adds step 2）In filter residue, mixing obtains mixture, adds mixture weight 4-6 times
Distilled water, soaks 1-2 hours, and backflow decocts 2-3 hours, filters, and adds the distilled water of mixture weight 2-3 times, and backflow is decocted
1-1..5 hours are boiled, are filtered, merging filtrate, be evaporated to the medicinal extract that relative density under 65-75 DEG C of environment is 1.20-1.25,
Drying under reduced pressure, crosses 80-100 mesh sieves after crushing, obtain medicinal extract fine powder；
5）Borneol and beeswax are ground into into fine powder, 80-100 mesh sieves are crossed, it is standby；
6）By dilleniad extract, barberry extract and step 2）Middle medicinal extract fine powder and step 4）Middle medicinal extract fine powder and step 5）
Middle fine powder mixing, stirs, and obtains final product pharmaceutical composition of the present invention.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201710143091.8A CN106620069A (en) | 2017-03-10 | 2017-03-10 | Medicinal composition for treating skin allergy caused by insect bites and stings and preparation method of medicinal composition |
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| Application Number | Priority Date | Filing Date | Title |
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| CN201710143091.8A CN106620069A (en) | 2017-03-10 | 2017-03-10 | Medicinal composition for treating skin allergy caused by insect bites and stings and preparation method of medicinal composition |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP4000689A1 (en) * | 2020-11-17 | 2022-05-25 | Fethiann Molecule Applied Co., Ltd. | Magnolia figo extract for use in reducing epidermal desquamation and promoting wound healing |
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| CN102716394A (en) * | 2012-06-13 | 2012-10-10 | 中国人民解放军总医院 | Medicine composition for treating skin diseases |
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| CN103705552A (en) * | 2013-12-26 | 2014-04-09 | 福建金源泉科技发展有限公司 | External liniment with function of improving allergy |
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| CN101953763A (en) * | 2009-07-20 | 2011-01-26 | 梁振 | Chinese medicinal herb repellent liquid |
| CN102716394A (en) * | 2012-06-13 | 2012-10-10 | 中国人民解放军总医院 | Medicine composition for treating skin diseases |
| CN102940715A (en) * | 2012-10-30 | 2013-02-27 | 广西梧州三鹤药业有限公司 | Pseudo-ginseng ointment and preparation method thereof |
| CN103705552A (en) * | 2013-12-26 | 2014-04-09 | 福建金源泉科技发展有限公司 | External liniment with function of improving allergy |
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