CN106619223A - Natural anti-aging cosmetic and preparation method thereof - Google Patents
Natural anti-aging cosmetic and preparation method thereof Download PDFInfo
- Publication number
- CN106619223A CN106619223A CN201611237337.XA CN201611237337A CN106619223A CN 106619223 A CN106619223 A CN 106619223A CN 201611237337 A CN201611237337 A CN 201611237337A CN 106619223 A CN106619223 A CN 106619223A
- Authority
- CN
- China
- Prior art keywords
- component
- skin
- genistein
- natural anti
- aging
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000002537 cosmetic Substances 0.000 title claims abstract description 44
- 230000003712 anti-aging effect Effects 0.000 title claims abstract description 33
- 238000002360 preparation method Methods 0.000 title claims abstract description 11
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims abstract description 27
- 239000002994 raw material Substances 0.000 claims abstract description 26
- TZBJGXHYKVUXJN-UHFFFAOYSA-N genistein Natural products C1=CC(O)=CC=C1C1=COC2=CC(O)=CC(O)=C2C1=O TZBJGXHYKVUXJN-UHFFFAOYSA-N 0.000 claims abstract description 24
- 235000006539 genistein Nutrition 0.000 claims abstract description 24
- 229940045109 genistein Drugs 0.000 claims abstract description 24
- ZCOLJUOHXJRHDI-CMWLGVBASA-N genistein 7-O-beta-D-glucoside Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1OC1=CC(O)=C2C(=O)C(C=3C=CC(O)=CC=3)=COC2=C1 ZCOLJUOHXJRHDI-CMWLGVBASA-N 0.000 claims abstract description 24
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 21
- IQVQXVFMNOFTMU-FLIBITNWSA-N (Z)-ligustilide Chemical compound C1CC=CC2=C1C(=C/CCC)/OC2=O IQVQXVFMNOFTMU-FLIBITNWSA-N 0.000 claims abstract description 20
- IQVQXVFMNOFTMU-DHZHZOJOSA-N Z-ligustilide Natural products C1CC=CC2=C1C(=C/CCC)\OC2=O IQVQXVFMNOFTMU-DHZHZOJOSA-N 0.000 claims abstract description 20
- 239000008367 deionised water Substances 0.000 claims abstract description 19
- 229910021641 deionized water Inorganic materials 0.000 claims abstract description 19
- VBICKXHEKHSIBG-UHFFFAOYSA-N 1-monostearoylglycerol Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCC(O)CO VBICKXHEKHSIBG-UHFFFAOYSA-N 0.000 claims abstract description 14
- WTVHAMTYZJGJLJ-UHFFFAOYSA-N (+)-(4S,8R)-8-epi-beta-bisabolol Natural products CC(C)=CCCC(C)C1(O)CCC(C)=CC1 WTVHAMTYZJGJLJ-UHFFFAOYSA-N 0.000 claims abstract description 13
- RGZSQWQPBWRIAQ-CABCVRRESA-N (-)-alpha-Bisabolol Chemical compound CC(C)=CCC[C@](C)(O)[C@H]1CCC(C)=CC1 RGZSQWQPBWRIAQ-CABCVRRESA-N 0.000 claims abstract description 13
- 229920002385 Sodium hyaluronate Polymers 0.000 claims abstract description 13
- RGZSQWQPBWRIAQ-LSDHHAIUSA-N alpha-Bisabolol Natural products CC(C)=CCC[C@@](C)(O)[C@@H]1CCC(C)=CC1 RGZSQWQPBWRIAQ-LSDHHAIUSA-N 0.000 claims abstract description 13
- 229940036350 bisabolol Drugs 0.000 claims abstract description 13
- HHGZABIIYIWLGA-UHFFFAOYSA-N bisabolol Natural products CC1CCC(C(C)(O)CCC=C(C)C)CC1 HHGZABIIYIWLGA-UHFFFAOYSA-N 0.000 claims abstract description 13
- XUGNVMKQXJXZCD-UHFFFAOYSA-N isopropyl palmitate Chemical compound CCCCCCCCCCCCCCCC(=O)OC(C)C XUGNVMKQXJXZCD-UHFFFAOYSA-N 0.000 claims abstract description 13
- 229940119170 jojoba wax Drugs 0.000 claims abstract description 13
- LXCFILQKKLGQFO-UHFFFAOYSA-N p-hydroxybenzoic acid methyl ester Natural products COC(=O)C1=CC=C(O)C=C1 LXCFILQKKLGQFO-UHFFFAOYSA-N 0.000 claims abstract description 13
- 229920002401 polyacrylamide Polymers 0.000 claims abstract description 13
- 229940010747 sodium hyaluronate Drugs 0.000 claims abstract description 13
- YWIVKILSMZOHHF-QJZPQSOGSA-N sodium;(2s,3s,4s,5r,6r)-6-[(2s,3r,4r,5s,6r)-3-acetamido-2-[(2s,3s,4r,5r,6r)-6-[(2r,3r,4r,5s,6r)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2- Chemical compound [Na+].CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 YWIVKILSMZOHHF-QJZPQSOGSA-N 0.000 claims abstract description 13
- AXTGDCSMTYGJND-UHFFFAOYSA-N 1-dodecylazepan-2-one Chemical compound CCCCCCCCCCCCN1CCCCCC1=O AXTGDCSMTYGJND-UHFFFAOYSA-N 0.000 claims abstract description 7
- WSDISUOETYTPRL-UHFFFAOYSA-N dmdm hydantoin Chemical compound CC1(C)N(CO)C(=O)N(CO)C1=O WSDISUOETYTPRL-UHFFFAOYSA-N 0.000 claims abstract 3
- 239000000284 extract Substances 0.000 claims description 22
- 239000002253 acid Substances 0.000 claims description 19
- 241000125175 Angelica Species 0.000 claims description 16
- 235000001287 Guettarda speciosa Nutrition 0.000 claims description 16
- 150000001413 amino acids Chemical class 0.000 claims description 13
- 125000000217 alkyl group Chemical group 0.000 claims description 12
- 235000011187 glycerol Nutrition 0.000 claims description 12
- 239000003906 humectant Substances 0.000 claims description 12
- 125000000913 palmityl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 claims description 12
- 238000003756 stirring Methods 0.000 claims description 12
- -1 methylparaben amino acid Chemical class 0.000 abstract description 7
- 230000009758 senescence Effects 0.000 abstract description 6
- 239000004615 ingredient Substances 0.000 abstract description 3
- CJWQYWQDLBZGPD-UHFFFAOYSA-N isoflavone Natural products C1=C(OC)C(OC)=CC(OC)=C1C1=COC2=C(C=CC(C)(C)O3)C3=C(OC)C=C2C1=O CJWQYWQDLBZGPD-UHFFFAOYSA-N 0.000 abstract description 3
- 150000002515 isoflavone derivatives Chemical class 0.000 abstract description 3
- 235000008696 isoflavones Nutrition 0.000 abstract description 3
- 230000001934 delay Effects 0.000 abstract description 2
- KSEBMYQBYZTDHS-HWKANZROSA-M (E)-Ferulic acid Natural products COC1=CC(\C=C\C([O-])=O)=CC=C1O KSEBMYQBYZTDHS-HWKANZROSA-M 0.000 abstract 3
- KSEBMYQBYZTDHS-HWKANZROSA-N ferulic acid Chemical compound COC1=CC(\C=C\C(O)=O)=CC=C1O KSEBMYQBYZTDHS-HWKANZROSA-N 0.000 abstract 3
- 235000001785 ferulic acid Nutrition 0.000 abstract 3
- 229940114124 ferulic acid Drugs 0.000 abstract 3
- KSEBMYQBYZTDHS-UHFFFAOYSA-N ferulic acid Natural products COC1=CC(C=CC(O)=O)=CC=C1O KSEBMYQBYZTDHS-UHFFFAOYSA-N 0.000 abstract 3
- QURCVMIEKCOAJU-UHFFFAOYSA-N trans-isoferulic acid Natural products COC1=CC=C(C=CC(O)=O)C=C1O QURCVMIEKCOAJU-UHFFFAOYSA-N 0.000 abstract 3
- PAEMERHSTIDLSE-QMCAAQAGSA-N (2r,3r,4s,5s,6r)-2-hexadecoxy-6-(hydroxymethyl)oxane-3,4,5-triol Chemical compound CCCCCCCCCCCCCCCCO[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O PAEMERHSTIDLSE-QMCAAQAGSA-N 0.000 abstract 1
- 235000010469 Glycine max Nutrition 0.000 abstract 1
- 244000068988 Glycine max Species 0.000 abstract 1
- 239000004909 Moisturizer Substances 0.000 abstract 1
- 229940075507 glyceryl monostearate Drugs 0.000 abstract 1
- 235000010270 methyl p-hydroxybenzoate Nutrition 0.000 abstract 1
- 239000004292 methyl p-hydroxybenzoate Substances 0.000 abstract 1
- 229960002216 methylparaben Drugs 0.000 abstract 1
- 230000001333 moisturizer Effects 0.000 abstract 1
- 239000001788 mono and diglycerides of fatty acids Substances 0.000 abstract 1
- 230000002195 synergetic effect Effects 0.000 abstract 1
- 210000003491 skin Anatomy 0.000 description 56
- 238000012360 testing method Methods 0.000 description 38
- 230000000694 effects Effects 0.000 description 23
- 230000037394 skin elasticity Effects 0.000 description 19
- 239000000523 sample Substances 0.000 description 17
- 230000032683 aging Effects 0.000 description 13
- 239000013068 control sample Substances 0.000 description 13
- 230000037303 wrinkles Effects 0.000 description 13
- 230000006870 function Effects 0.000 description 10
- 230000009759 skin aging Effects 0.000 description 10
- 230000008859 change Effects 0.000 description 8
- 238000000034 method Methods 0.000 description 8
- 230000002087 whitening effect Effects 0.000 description 7
- 229940011871 estrogen Drugs 0.000 description 6
- 239000000262 estrogen Substances 0.000 description 6
- 229910052757 nitrogen Inorganic materials 0.000 description 6
- IJGRMHOSHXDMSA-UHFFFAOYSA-N nitrogen Substances N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 6
- 150000003254 radicals Chemical class 0.000 description 6
- 230000008569 process Effects 0.000 description 5
- XUMBMVFBXHLACL-UHFFFAOYSA-N Melanin Chemical compound O=C1C(=O)C(C2=CNC3=C(C(C(=O)C4=C32)=O)C)=C2C4=CNC2=C1C XUMBMVFBXHLACL-UHFFFAOYSA-N 0.000 description 4
- 238000010521 absorption reaction Methods 0.000 description 4
- 230000007423 decrease Effects 0.000 description 4
- 230000009245 menopause Effects 0.000 description 4
- 239000000203 mixture Substances 0.000 description 4
- 102000008186 Collagen Human genes 0.000 description 3
- 108010035532 Collagen Proteins 0.000 description 3
- 241000196324 Embryophyta Species 0.000 description 3
- 208000003351 Melanosis Diseases 0.000 description 3
- 238000006243 chemical reaction Methods 0.000 description 3
- 229920001436 collagen Polymers 0.000 description 3
- 125000004122 cyclic group Chemical group 0.000 description 3
- 239000003814 drug Substances 0.000 description 3
- 210000002615 epidermis Anatomy 0.000 description 3
- 210000001061 forehead Anatomy 0.000 description 3
- 150000002632 lipids Chemical class 0.000 description 3
- 239000000463 material Substances 0.000 description 3
- 238000005259 measurement Methods 0.000 description 3
- 210000000216 zygoma Anatomy 0.000 description 3
- QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 description 2
- 102000004190 Enzymes Human genes 0.000 description 2
- 108090000790 Enzymes Proteins 0.000 description 2
- 206010020649 Hyperkeratosis Diseases 0.000 description 2
- 208000001126 Keratosis Diseases 0.000 description 2
- 239000004480 active ingredient Substances 0.000 description 2
- 238000004458 analytical method Methods 0.000 description 2
- 230000003064 anti-oxidating effect Effects 0.000 description 2
- 230000003078 antioxidant effect Effects 0.000 description 2
- 230000015572 biosynthetic process Effects 0.000 description 2
- 230000017531 blood circulation Effects 0.000 description 2
- 230000008021 deposition Effects 0.000 description 2
- 235000005911 diet Nutrition 0.000 description 2
- 230000037213 diet Effects 0.000 description 2
- 230000007613 environmental effect Effects 0.000 description 2
- 230000001076 estrogenic effect Effects 0.000 description 2
- 238000000605 extraction Methods 0.000 description 2
- 210000000887 face Anatomy 0.000 description 2
- 235000013305 food Nutrition 0.000 description 2
- 239000011159 matrix material Substances 0.000 description 2
- 230000007246 mechanism Effects 0.000 description 2
- 239000012528 membrane Substances 0.000 description 2
- OKKJLVBELUTLKV-UHFFFAOYSA-N methanol Natural products OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 2
- 239000000178 monomer Substances 0.000 description 2
- 230000036651 mood Effects 0.000 description 2
- 230000002265 prevention Effects 0.000 description 2
- 238000011084 recovery Methods 0.000 description 2
- 230000000638 stimulation Effects 0.000 description 2
- 208000037259 Amyloid Plaque Diseases 0.000 description 1
- 241000213006 Angelica dahurica Species 0.000 description 1
- 241000208340 Araliaceae Species 0.000 description 1
- 206010003694 Atrophy Diseases 0.000 description 1
- 235000005979 Citrus limon Nutrition 0.000 description 1
- 244000131522 Citrus pyriformis Species 0.000 description 1
- CIWBSHSKHKDKBQ-DUZGATOHSA-N D-isoascorbic acid Chemical compound OC[C@@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-DUZGATOHSA-N 0.000 description 1
- 201000004624 Dermatitis Diseases 0.000 description 1
- 206010013786 Dry skin Diseases 0.000 description 1
- 102100038595 Estrogen receptor Human genes 0.000 description 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 1
- CWYNVVGOOAEACU-UHFFFAOYSA-N Fe2+ Chemical compound [Fe+2] CWYNVVGOOAEACU-UHFFFAOYSA-N 0.000 description 1
- 229920001503 Glucan Polymers 0.000 description 1
- 241000244365 Ligusticum sinense Species 0.000 description 1
- 235000005035 Panax pseudoginseng ssp. pseudoginseng Nutrition 0.000 description 1
- 235000003140 Panax quinquefolius Nutrition 0.000 description 1
- 235000014676 Phragmites communis Nutrition 0.000 description 1
- 241000221095 Simmondsia Species 0.000 description 1
- 235000004433 Simmondsia californica Nutrition 0.000 description 1
- 206010040880 Skin irritation Diseases 0.000 description 1
- OUUQCZGPVNCOIJ-UHFFFAOYSA-M Superoxide Chemical compound [O-][O] OUUQCZGPVNCOIJ-UHFFFAOYSA-M 0.000 description 1
- 102100024036 Tyrosine-protein kinase Lck Human genes 0.000 description 1
- 208000027418 Wounds and injury Diseases 0.000 description 1
- 230000002159 abnormal effect Effects 0.000 description 1
- 230000001133 acceleration Effects 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 230000004913 activation Effects 0.000 description 1
- 230000007815 allergy Effects 0.000 description 1
- 229940069521 aloe extract Drugs 0.000 description 1
- 229910021529 ammonia Inorganic materials 0.000 description 1
- 230000008485 antagonism Effects 0.000 description 1
- 230000001833 anti-estrogenic effect Effects 0.000 description 1
- 230000003110 anti-inflammatory effect Effects 0.000 description 1
- 230000001153 anti-wrinkle effect Effects 0.000 description 1
- 239000003963 antioxidant agent Substances 0.000 description 1
- 235000006708 antioxidants Nutrition 0.000 description 1
- 230000037444 atrophy Effects 0.000 description 1
- 230000003796 beauty Effects 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000008901 benefit Effects 0.000 description 1
- 230000005540 biological transmission Effects 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 210000004027 cell Anatomy 0.000 description 1
- 230000032677 cell aging Effects 0.000 description 1
- 230000004663 cell proliferation Effects 0.000 description 1
- 239000003153 chemical reaction reagent Substances 0.000 description 1
- 230000000536 complexating effect Effects 0.000 description 1
- 239000000470 constituent Substances 0.000 description 1
- 230000006378 damage Effects 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 230000035622 drinking Effects 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 235000013399 edible fruits Nutrition 0.000 description 1
- 230000002500 effect on skin Effects 0.000 description 1
- 210000004177 elastic tissue Anatomy 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 210000001339 epidermal cell Anatomy 0.000 description 1
- 108010038795 estrogen receptors Proteins 0.000 description 1
- 238000011156 evaluation Methods 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 210000001508 eye Anatomy 0.000 description 1
- 230000001815 facial effect Effects 0.000 description 1
- 210000001097 facial muscle Anatomy 0.000 description 1
- 229910001448 ferrous ion Inorganic materials 0.000 description 1
- 230000014509 gene expression Effects 0.000 description 1
- 235000008434 ginseng Nutrition 0.000 description 1
- 235000020710 ginseng extract Nutrition 0.000 description 1
- 210000003128 head Anatomy 0.000 description 1
- 239000005556 hormone Substances 0.000 description 1
- 229940088597 hormone Drugs 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 208000014674 injury Diseases 0.000 description 1
- 238000007689 inspection Methods 0.000 description 1
- 150000002596 lactones Chemical class 0.000 description 1
- 239000002346 layers by function Substances 0.000 description 1
- 239000006210 lotion Substances 0.000 description 1
- 239000002932 luster Substances 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 230000010534 mechanism of action Effects 0.000 description 1
- 239000002207 metabolite Substances 0.000 description 1
- 230000004089 microcirculation Effects 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000003020 moisturizing effect Effects 0.000 description 1
- 230000004660 morphological change Effects 0.000 description 1
- 239000005445 natural material Substances 0.000 description 1
- 231100000252 nontoxic Toxicity 0.000 description 1
- 230000003000 nontoxic effect Effects 0.000 description 1
- 235000015097 nutrients Nutrition 0.000 description 1
- 239000004006 olive oil Substances 0.000 description 1
- 235000008390 olive oil Nutrition 0.000 description 1
- 230000003287 optical effect Effects 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- 238000011056 performance test Methods 0.000 description 1
- 230000035699 permeability Effects 0.000 description 1
- 150000003904 phospholipids Chemical class 0.000 description 1
- 230000035790 physiological processes and functions Effects 0.000 description 1
- 239000003075 phytoestrogen Substances 0.000 description 1
- 239000010773 plant oil Substances 0.000 description 1
- 239000003755 preservative agent Substances 0.000 description 1
- 230000002335 preservative effect Effects 0.000 description 1
- 230000001737 promoting effect Effects 0.000 description 1
- 230000005855 radiation Effects 0.000 description 1
- 238000007348 radical reaction Methods 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 230000000979 retarding effect Effects 0.000 description 1
- 210000001732 sebaceous gland Anatomy 0.000 description 1
- 210000000697 sensory organ Anatomy 0.000 description 1
- 230000037384 skin absorption Effects 0.000 description 1
- 231100000274 skin absorption Toxicity 0.000 description 1
- 210000004927 skin cell Anatomy 0.000 description 1
- 208000017520 skin disease Diseases 0.000 description 1
- 230000036556 skin irritation Effects 0.000 description 1
- 231100000475 skin irritation Toxicity 0.000 description 1
- 230000036548 skin texture Effects 0.000 description 1
- 230000000391 smoking effect Effects 0.000 description 1
- 235000010352 sodium erythorbate Nutrition 0.000 description 1
- 241000894007 species Species 0.000 description 1
- 238000007619 statistical method Methods 0.000 description 1
- 238000007920 subcutaneous administration Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- 238000005211 surface analysis Methods 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
- 210000001138 tear Anatomy 0.000 description 1
- 238000010998 test method Methods 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- 239000011573 trace mineral Substances 0.000 description 1
- 235000013619 trace mineral Nutrition 0.000 description 1
- 239000011782 vitamin Substances 0.000 description 1
- 229940088594 vitamin Drugs 0.000 description 1
- 235000013343 vitamin Nutrition 0.000 description 1
- 229930003231 vitamin Natural products 0.000 description 1
- 150000003722 vitamin derivatives Chemical class 0.000 description 1
- 239000000341 volatile oil Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
- A61K8/922—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/345—Alcohols containing more than one hydroxy group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/36—Carboxylic acids; Salts or anhydrides thereof
- A61K8/365—Hydroxycarboxylic acids; Ketocarboxylic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/37—Esters of carboxylic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/37—Esters of carboxylic acids
- A61K8/375—Esters of carboxylic acids the alcohol moiety containing more than one hydroxy group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/4906—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with one nitrogen as the only hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/494—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom
- A61K8/4946—Imidazoles or their condensed derivatives, e.g. benzimidazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/4973—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/4973—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom
- A61K8/498—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom having 6-membered rings or their condensed derivatives, e.g. coumarin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/60—Sugars; Derivatives thereof
- A61K8/604—Alkylpolyglycosides; Derivatives thereof, e.g. esters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/735—Mucopolysaccharides, e.g. hyaluronic acid; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/81—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions involving only carbon-to-carbon unsaturated bonds
- A61K8/8141—Compositions of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by only one carboxyl radical, or of salts, anhydrides, esters, amides, imides or nitriles thereof; Compositions of derivatives of such polymers
- A61K8/8158—Homopolymers or copolymers of amides or imides, e.g. (meth) acrylamide; Compositions of derivatives of such polymers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/02—Preparations for care of the skin for chemically bleaching or whitening the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Birds (AREA)
- Emergency Medicine (AREA)
- Dermatology (AREA)
- Chemical & Material Sciences (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Gerontology & Geriatric Medicine (AREA)
- Cosmetics (AREA)
Abstract
The invention provides a natural anti-aging cosmetic and a preparation method thereof. The cosmetic is prepared from the following raw materials: component A: jojoba oil, isopropyl palmitate, polyacrylamide, bisabolol, azone, hexadecyl glucoside and glyceryl monostearate; component B: sodium hyaluronate, a methylparaben amino acid moisturizer, 1,3-dihydroxylmethyl-5,5-dimethylhydantoin; component C: genistein, ferulic acid, ligustilide and glycerol; the balance of deionized water, and the total weight percentage of the raw materials is 100%. The natural anti-aging cosmetic is applicable to postmenopausal women, and fundamentally delays the senescence of the postmenopausal women by adding genistein as an effective ingredient of soybean isoflavones as well as ferulic acid and ligustilide; genistein is used in combination with ferulic acid and ligustilide and can play a more synergistic role.
Description
Technical field
The present invention relates to cosmetic field, more particularly to a kind of natural anti-aging cosmetics and preparation method thereof.
Background technology
With advancing age, must all there are a series of retrogressions in terms of morphosis and physiological function in body
Change, here it is usually said " aging ".Skin senescence is an important component part of body aging, especially to postclimacteric
For women, the change of skin is huge, and the change of skin collagen causes skin elasticity reduction, effect of elastic resistance to weaken, therefore,
The beauty skin care product of various preventions and delay skin aging is increasingly subject to people's attention.
In view of injury of the chemistry skin care item to skin at present, people turn to sight has good safety, stability, effect
Fruit substantially and the high natural anti-aging cosmetics of cost performance, such as various Chinese medicine cosmetics.Application in TCM has in beautifying skin
Efficacy stability, persistently, to skin action temperature and, excitant it is little, safe, it is evident in efficacy the features such as.Patent
201510173817.3 disclose it is a kind of with whitening and anti-aging, remove wrinkle, the cosmetic composition of spot-removing function and cosmetics,
The function adding ingredient of this cosmetics have oat extract, Ginseng extract, arabo-ascorbic acid, Ma Zhi look for extract, glucan,
Reed fragrant plant oil, aloe extract, lemon yellow Jojoba coloured silk particle, ginseng one, whitening effect is good, goes wrinkle effect good, nti-freckle ability
It is remarkable.But the shortcoming of the present invention has:(1) containing various natural extracts, species is more so that extraction process is more complicated, while
Due to complicated component, it is difficult to determine the anti-ageing, whitening of performance, remove wrinkle, the concrete composition of nti-freckle and specific mechanism of action;(2) nothing
Method determines ratio standard when making, because different sources, the same medicine of different cultivars, its composition and content have difference,
Therefore the constituent structure of extract can be affected;(3) this cosmetics function is numerous, whitening and anti-aging, go wrinkle, nti-freckle, it can be difficult to
Determine that what its effect for accounting for main advantage is;(4) plurality of Chinese extract component is mixed and chemical matrix is blended in
After together, if unknown reaction can be played, the characteristic and function of cosmetics is affected.
Patent 201510165517.0 discloses a kind of skin care item formula of delay skin aging, fills a prescription by parts by weight
1 part of Aloe Vera Gel, 1 part of body lotion, 1 part of olive oil, 1 part of vitamin are made.The present invention can be disposed and cause Skin Cell aging
Free radical, can provide nutrient necessary to skin, and energy nourishes rough skin while skin surface free radical is removed, delaying skin declines
Always, cell senescence and the melanin deposition caused due to ultraviolet radiation can also be alleviated, is reached while delay skin aging
To the effect of skin whitening.But the present invention is the nourishing and protection on surface, activation and again can not be played to the functional layer of skin
Raw effect, it is impossible to the fundamentally aging of delaying skin.
Skin senescence is endogenous physiological aging and the coefficient result of exogenous environmental factor, and endogenous aging is root
This, environmental factor plays acceleration or retarding action on the basis of endogenous aging, therefore can solve in postmenopausal women for research
The natural cosmetics tool significance of source property aging.
The content of the invention
The purpose of the present invention is mainly to provide a kind of natural anti-aging cosmetics suitable for postmenopausal women and its preparation
Method, by the active ingredient genistein for adding plant estrogen isoflavones, fundamentally delays postmenopausal women
Aging.
The technical solution used in the present invention is as follows:
A kind of natural anti-aging cosmetics, are prepared from by the raw material of following percentage by weight:
Component A:Jojoba oil 2-8%, isopropyl palmitate 0.5-4%, polyacrylamide 0.2-4%, bisabolol
0.01-0.5%, azone 0.01-0.5%, Alkyl Polyglycoside of Hexadecyl 1-6%, glycerin monostearate 1-7%;
B component:Sodium Hyaluronate 1-5%, methyl hydroxybenzoate 0.2-0.4%, amino acid humectant 0.5-5%, 1,3- bis-
Methylol -5,5- dimethyl hydantoin 0.2-0.5%;
Component C:Genistein 0.1-0.4%, forulic acid 0.01-0.05%, ligustilide 0.01-0.05%, glycerine 1-
7%;
Balance of deionized water, adds up to 100%;
Preferably, the natural anti-aging cosmetics are prepared from by the raw material of following percentage by weight:
Component A:Jojoba oil 5%, isopropyl palmitate 1.0%, polyacrylamide 0.6%, bisabolol 0.1%, nitrogen
Ketone 0.1%, Alkyl Polyglycoside of Hexadecyl 2.5%, glycerin monostearate 1%;
B component:Sodium Hyaluronate 3.0%, methyl hydroxybenzoate 0.2%, amino acid humectant 2.0%, 1,3- dihydroxymethyls-
5,5- dimethyl hydantoins 0.1%;
Component C:Genistein 0.2%, forulic acid 0.02%, ligustilide 0.02%, glycerine 3.0%;
Balance of deionized water, adds up to 100%.
Main functional component is genistein in technical scheme, and genistein is mainly having for isoflavones
Effect composition, with antioxidation, with estrogen and antiestrogenic property, can suppress the activity for opening up analysis foreign matter enzyme II, can press down
The activity of LCK PTK processed.Its molecular weight is relatively low, can be dissolved in matrix and can absorbing transmission from skin, with
The ERs combination of skin of face, promotes skin collagen synthesis, stimulates epidermal cell proliferation, affects dividing for sebaceous glands
Secrete, delay cuticula atrophy and epidermis thinning, keep skin elasticity, reduce wrinkle, play estrogen-like action, meanwhile, may be used also
With by anti-oxidant come delay skin aging.
In the technical program, also added active ingredient forulic acid and ligustilide, both of which from angelica extract,
Forulic acid has antioxidation, by directly eliminating free radical, suppresses the membrane lipid peroxidatio reaction that superoxide radical causes
And radical reaction, and the infringement with various mechanism antagonism free radicals such as biological film phospholipid join protection membrane lipid to organizing,
Gloomy or not magnificent to the complexion caused by free radical retardance or raw sore swells, there is special efficacy.Additionally, forulic acid also has anti-inflammatory, pain relieving
Effect, while also good Transdermal absorption function is permeated with Transdermal absorption function, the absorption that can promote genistein is promoted;Ligusticum sinense oliver
Lactone is the main component of Chinese angelica volatile oil, with effect that is promoting blood circulation and removing blood stasis, improving skin microcirculation, can keep the life of skin
State is balanced, and prevents skin from abnormal change occurring, and controls deposition of the lipid metabolite in skin, prevention skin aging and senile plaque expelling
Generation.
A kind of natural anti-aging cosmetics, are prepared from by the raw material of following percentage by weight:
Component A:Jojoba oil 2-8%, isopropyl palmitate 0.5-4%, polyacrylamide 0.2-4%, bisabolol
0.01-0.5%, azone 0.01-0.5%, Alkyl Polyglycoside of Hexadecyl 1-6%, glycerin monostearate 1-7%;
B component:Sodium Hyaluronate 1-5%, methyl hydroxybenzoate 0.2-0.4%, amino acid humectant 0.5-5%, 1,3- bis-
Methylol -5,5- dimethyl hydantoin 0.2-0.5%;
Component C:Genistein 0.1-0.4%, angelica extract 0.5-2.0%, glycerine 1-7%;
Balance of deionized water, adds up to 100%;
Containing forulic acid and ligustilide wherein in angelica extract.
Preferably, the natural anti-aging cosmetics are prepared from by the raw material of following percentage by weight:
Component A:Jojoba oil 5%, isopropyl palmitate 1.0%, polyacrylamide 0.6%, bisabolol 0.1%, nitrogen
Ketone 0.1%, Alkyl Polyglycoside of Hexadecyl 2.5%, glycerin monostearate 1%;
B component:Sodium Hyaluronate 3.0%, methyl hydroxybenzoate 0.2%, amino acid humectant 2.0%, 1,3- dihydroxymethyls-
5,5- dimethyl hydantoins 0.1%;
Component C:Genistein 0.2%, angelica extract 2.0%, glycerine 3.0%;
Balance of deionized water, adds up to 100%;
Containing forulic acid and ligustilide wherein in angelica extract.
In the technical program, pure forulic acid and ligustilide is replaced using angelica extract, not only reduce production
Cost, it is even more important that angelica extract in addition to containing forulic acid and ligustilide, also containing amino acid, trace element and
Other organic principles, therefore angelica extract not only has the function of forulic acid and ligustilide, also with other functions, such as
Angelica extract has abundant moisture-keeping functions, stores after skin absorption and is contained in epidermis, makes keratoderma keep the aqueous of abundance
Amount, plays " direct moisturizing " mechanism.Angelica extract also has removes free radical and complexing ferrous ion ability and to junket ammonia
Sour enzyme has rejection ability, plays anti-aging and whitening function.
Further, the cosmetics are primarily adapted for use in postclimacteric old women.
A kind of preparation method of above-mentioned anti-aging cosmetics, comprises the following steps:
S1:All raw materials of component A are heated into 80-90 DEG C in beaker, I phases are stirred to after being completely dissolved to obtain;
S2:All raw materials of B component are added one by one in deionized water, 80-90 DEG C is heated to, is stirred to after being completely dissolved
Obtain II phase;
S3:II is added in I phases, with homogenizer homogeneous 1-5min, stirring is cooled to 40 DEG C, adds component C, stir to
It is well mixed.
The present invention shares genistein with angelica extract with forulic acid and ligustilide or genistein, can play more
Good collaboration facilitation, so that its delay skin aging, keeps skin of face elasticity, reduces wrinkle, promotes face blood
Circulation, keeps having rosy cheeks, and suppresses the formation of dermal melanin, also acts as skin whitening effect.Plant can also be promoted female sharp simultaneously
The Transdermal absorption of element, drug extract itself can play the good anti-oxidant effect of guaranteeing the quality again.
The present invention anti-aging cosmetics be primarily adapted for use in women after menopause, to solve menopause after women endogenous physiological
For the purpose of aging, pure white fine and smooth, the pure and fresh simple and elegant, sense organ of smell of color and luster comfortably moistens, non-greasy, good permeability, sooner or later can
Use, and without essence and preservative, it is little to skin irritation, have no toxic side effect, it is safe and reliable.
Specific embodiment
The principle and feature of the present invention are described below, example is served only for explaining the present invention, is not intended to limit
Determine the scope of the present invention.
The part material source arrived used in following examples is as follows:Genistein (purity 98wt%) is purchased from Yuquan monomer
Storehouse;Forulic acid (purity >=98wt%), ligustilide (purity >=98wt%) are purchased from Shanghai experiment reagent consumptive material home office;Radix Angelicae Sinensis is carried
Take thing to converge purchased from natural material.
Embodiment 1
A kind of natural anti-aging cosmetics, are prepared from by the raw material of following percentage by weight:
Component A:Jojoba oil 5%, isopropyl palmitate 1.0%, polyacrylamide 0.6%, bisabolol 0.1%, nitrogen
Ketone 0.1%, Alkyl Polyglycoside of Hexadecyl 2.5%, glycerin monostearate 1%;
B component:Sodium Hyaluronate 3.0%, methyl hydroxybenzoate 0.2%, amino acid humectant 2.0%, 1,3- dihydroxymethyls-
5,5- dimethyl hydantoins 0.1%;
Component C:Genistein 0.2%, forulic acid 0.02%, ligustilide 0.02%, glycerine 3.0%;
Balance of deionized water, adds up to 100%;
The preparation process of the natural anti-aging cosmetics is as follows:
S1:All raw materials of component A are heated into 80-90 DEG C in beaker, I phases are stirred to after being completely dissolved to obtain;
S2:All raw materials of B component are added one by one in deionized water, 80-90 DEG C is heated to, is stirred to after being completely dissolved
Obtain II phase;
S3:II is added in I phases, with homogenizer homogeneous 1-5min, stirring is cooled to 40 DEG C, adds component C, stir to
It is well mixed.
Embodiment 2
A kind of natural anti-aging cosmetics, are prepared from by the raw material of following percentage by weight:
Component A:Jojoba oil 2%, isopropyl palmitate 0.6%, polyacrylamide 0.3%, bisabolol 0.05%, nitrogen
Ketone 0.05%, Alkyl Polyglycoside of Hexadecyl 1.5%, glycerin monostearate 7%;
B component:Sodium Hyaluronate 2.0%, methyl hydroxybenzoate 0.2%, amino acid humectant 1.0%, 1,3- dihydroxymethyls-
5,5- dimethyl hydantoins 0.1%;
Component C:Genistein 0.2%, forulic acid 0.02%, ligustilide 0.02%, glycerine 2.0%;
Balance of deionized water, adds up to 100%;
The preparation process of the natural anti-aging cosmetics is as follows:
S1:All raw materials of component A are heated into 80-90 DEG C in beaker, I phases are stirred to after being completely dissolved to obtain;
S2:All raw materials of B component are added one by one in deionized water, 80-90 DEG C is heated to, is stirred to after being completely dissolved
Obtain II phase;
S3:II is added in I phases, with homogenizer homogeneous 1-5min, stirring is cooled to 40 DEG C, adds component C, stir to
It is well mixed.
Embodiment 3
A kind of natural anti-aging cosmetics, are prepared from by the raw material of following percentage by weight:
Component A:Jojoba oil 5%, isopropyl palmitate 1.0%, polyacrylamide 0.6%, bisabolol 0.1%, nitrogen
Ketone 0.1%, Alkyl Polyglycoside of Hexadecyl 2.5%, glycerin monostearate 1%;
B component:Sodium Hyaluronate 3.0%, methyl hydroxybenzoate 0.2%, amino acid humectant 2.0%, 1,3- dihydroxymethyls-
5,5- dimethyl hydantoins 0.1%;
Component C:Genistein 0.2%, angelica extract 2%, glycerine 3.0%;
Balance of deionized water, adds up to 100%;
The preparation process of the natural anti-aging cosmetics is as follows:
S1:All raw materials of component A are heated into 80-90 DEG C in beaker, I phases are stirred to after being completely dissolved to obtain;
S2:All raw materials of B component are added one by one in deionized water, 80-90 DEG C is heated to, is stirred to after being completely dissolved
Obtain II phase;
S3:II is added in I phases, with homogenizer homogeneous 1-5min, stirring is cooled to 40 DEG C, adds component C, stir to
It is well mixed.
Embodiment 4
A kind of natural anti-aging cosmetics, are prepared from by the raw material of following percentage by weight:
Component A:Jojoba oil 2%, isopropyl palmitate 0.6%, polyacrylamide 0.3%, bisabolol 0.05%, nitrogen
Ketone 0.05%, Alkyl Polyglycoside of Hexadecyl 1.5%, glycerin monostearate 7%;
B component:Sodium Hyaluronate 2.0%, methyl hydroxybenzoate 0.2%, amino acid humectant 1.0%, 1,3- dihydroxymethyls-
5,5- dimethyl hydantoins 0.1%;
Component C:Genistein 0.2%, angelica extract 0.5%, glycerine 2.0%;
Balance of deionized water, adds up to 100%;
The preparation process of the natural anti-aging cosmetics is as follows:
S1:All raw materials of component A are heated into 80-90 DEG C in beaker, I phases are stirred to after being completely dissolved to obtain;
S2:All raw materials of B component are added one by one in deionized water, 80-90 DEG C is heated to, is stirred to after being completely dissolved
Obtain II phase;
S3:II is added in I phases, with homogenizer homogeneous 1-5min, stirring is cooled to 40 DEG C, adds component C, stir to
It is well mixed.
The following is the anti-aging performance test to product:
1st, test object
In Kiamusze City the age physiological menopause in -75 years old 55 years old women, without major disease, without skin disease and allergy
History, do not apply some make up at ordinary times and go out at ordinary times less, without the strong Exposure to Sunlight of long-time, without habits of smoking and alcohol drinking person, test number is 40
People.
2nd, method of testing
(1) skin elasticity test
Sooner or later each to wipe once in tester's forehead, canthus and cheekbone portion as test zone, left side face wipes control sample,
Right side face wipes test sample, and genistein, forulic acid and Ligustilide, other components and embodiment 1 are not contained in control sample
Identical, test sample adopts the formula of embodiment 1, and using method is Blind Test (do not tell tester two kinds and wipe the white difference of faces).
Diet keeps light, rule during test, and the product of pungent stimulation and cold and cool raw food are eaten less, and the sleep for keeping rule sufficient is not long
Time strong Exposure to Sunlight, keeps the happiness that is in a light hearted mood, period not to wipe other cosmetics as far as possible.Using after two months, adopt
Cutometer MPA580 skin elasticities instrument tests the skin elasticity of wiped area, and test result is as shown in table 1.It is tested during test
Person loosens facial muscle groups, gently closes eyes, avoids speaking and various expressions in measurement process, and test environment phase is kept in measurement
To stable, light, sound interference are avoided;Probe positions are correct during skin surface direct measurement, should be same to same position
One tested region is carried out;Using firmly wanting uniform during probe, the pressure of applying should continued for constant.In order to preferably evaluate gained
Data, introduce parameter R2, R5 and R7, these three parameters represent the ability that original position is returned to after skin deformation, they
Value be closer to 1, skin elasticity is better.Wherein R2 indicates that the springback capacity Ua without skin during negative pressure draws with there is maximum during negative pressure
The ratio of the amount of stretching Uf;R5 for skin test first time cyclic process in skin recovery process elastic part Ur with plus negative pressure process
Elastic part Ue ratio;R7 for skin test first time cyclic process in skin recovery process elastic part Ur with it is current
The ratio of maximum tension amount Uf of skin in cyclic process.
(2) dermatoglyph test
Sooner or later each to wipe once in tester's forehead, canthus and cheekbone portion as test zone, left side face wipes control sample,
Right side face wipes test sample, and genistein, forulic acid and Ligustilide, other components and embodiment 1 are not contained in control sample
Identical, test sample adopts the formula of embodiment 1, and using method is Blind Test (do not tell tester two kinds and wipe the white difference of faces).
Diet keeps light, rule during test, and the product of pungent stimulation and cold and cool raw food are eaten less, and the sleep for keeping rule sufficient is not long
Time strong Exposure to Sunlight, keeps the happiness that is in a light hearted mood, period not to wipe other cosmetics as far as possible.Using after two months, using VC98
Viable skin surface analysis system tests the dermatoglyph of wiped area, and test result is as shown in table 2.Dermatoglyph test result
Evaluated using following four parameter:
Sesc:Show the peeling degree of keratoderma, drawn by the ratio for calculating bright pixel, value is less, and cuticula contains
The water yield is higher, and skin is more smooth;
Ser:Show skin roughness, drawn by the ratio for calculating dark pixel, value is higher, represents skin more coarse;
Sew:Show wrinkle of skin degree, proportional to the quantity of wrinkle and depth, wrinkle of skin is more, its value is higher;
Sesm:Show the smoothness of skin, proportional to the depth of wrinkle and form, value is bigger, and skin is more smooth.
(3) statistical method
Each being described property of parameter is analyzed using statistical package, skin elasticity, texture compare to be checked using t.
Inspection level α=0.05.
(4) test result
Before and after the control sample of table 1 and test sample are wiped, the coefficient of skin elasticity of different parts
In table 1, the value of R2, R5 and R7 before and after sample is used by contrast, using control sample and test sample
Afterwards, the value of R2, R5 and R7 increases, and difference is respectively provided with statistical significance (P ﹤ 0.05);Test sample is to skin elasticity
Effect compares with control sample, and difference has statistical significance (P ﹤ 0.05), and test sample effect is better than control sample, illustrates this
Product is really with the effect for improving old women skin elasticity after menopause more more preferable than control sample.
Before and after the control sample of table 2 and test sample are wiped, the texture parameter values of skin different parts
In table 2, by contrast using each dermatoglyph parameter before and after sample, using control sample and test specimens
After product, Ser, Sew, Sesc value decreases, and Sesm values increase, statistically significant (the P ﹤ of numerical value difference
0.05);Test sample compares the effect of dermatoglyph with control sample, and difference has statistical significance (P ﹤ 0.05), test
Sample effect is better than control sample, illustrates that the product for adding active component improves ratio without active component to dermatoglyph
Product is bigger, is more beneficial for post menopausal old women skin smooth and moistens, and texture is reduced.
(5) discuss
Skin elasticity goes down, texture increases and deepens the key character for being skin senescence.These skin surface characteristics are entered
Row quantifies, evaluates, and is that cosmetic dermatology studies commonly used important means.
The anti-wrinkle effect of the present invention is also adopted by skin elasticity, dermatoglyph tester and is evaluated.Test skin elasticity
Principle is based on suction and stretching principle.Test result shows that post menopausal all ages and classes female skin elasticity is using test specimens
There is notable difference after product, the age is bigger, coefficient of skin elasticity value is lower, and skin elasticity is poorer.It is ultraviolet except outdoor activities
Line irradiation is outer, and age growth is to cause skin aging, the main cause of elasticity attenuation.Skin fine structure shows, collagenous fibres
Density increases with the age and increases, misaligned, and elastic fibers then increases with the age and weares and teares, and these changes cause skin
Elasticity is reduced.In face, canthus skin elasticity is most obvious with change of age, is the portion that facial skin aging occurs changing earliest
Position, is look-out station that optimum is elected to be anti-ageing cosmetics curative effect, next to that forehead and cheekbone portion.
Dermatoglyph change is also the important indicator of skin aging, dermatoglyph is quantified using dermatoglyph measuring instrument examine
Survey, also play an important role in terms of cosmetics and skincare product evaluation of effect.Dermatoglyph measuring instrument VC98 that this test is used, is to adopt
With optical principle, measuring head is contained within a digital camera, with the texture image of its shooting skin surface under UVA light sources, it
Afterwards again with software kit to graphical analysis, the corresponding parametric values of roughness are drawn.Experimental result shows, different parts skin
Be present significant difference in SESC, SER, SEW and SESM value dermatoglyph after using test sample, as a result anticipate with statistics
Justice.Showing that the age is bigger using each parameter of test sample rear face, its numerical value change value is bigger, illustrates that the age is bigger, skin
Texture and Flexible change are more prominent, also more obvious to the action-reaction of phytoestrogen.Because except time course is aging and light
Aging outer, the decline of postmenopausal estrogen level is also the key factor of skin aging.Decrease in estrogen can be made in skin
Collagen content is reduced, collagenous fibres quantity, is arranged and morphologic change, and epidermis is thinning, and water content is reduced, and skin elasticity occurs
Decline, wrinkle increases the aging performances such as intensification.Estrogen replacement increases elasticity, reduces wrinkle to improving old women skin senescence
Line has definite curative effect, but is to prohibit the use of hormone to add for safety in cosmetics adding ingredient operating specification
's.And the material with estrogen active extracted in plant, the gentle effect of natural disposition slowly, make by pair nontoxic to body to skin
With the monomer molecule amount of extraction is little, can fully be absorbed by the skin, and with skin and subcutaneous estrogen receptor binding reparation skin is reached
Skin structure, recovers elasticity, reduces the effect of wrinkle, makes aging skin recapture young life.
The foregoing is only presently preferred embodiments of the present invention, not to limit the present invention, all spirit in the present invention and
Within principle, any modification, equivalent substitution and improvements made etc. should be included within the scope of the present invention.
Claims (6)
1. a kind of natural anti-aging cosmetics, it is characterised in that be prepared from by the raw material of following percentage by weight:
Component A:Jojoba oil 2-8%, isopropyl palmitate 0.5-4%, polyacrylamide 0.2-4%, bisabolol 0.01-
0.5%th, azone 0.01-0.5%, Alkyl Polyglycoside of Hexadecyl 1-6%, glycerin monostearate 1-7%;
B component:Sodium Hyaluronate 1-5%, methyl hydroxybenzoate 0.2-0.4%, amino acid humectant 0.5-5%, 1,3- dihydroxy first
Base -5,5- dimethyl hydantoin 0.2-0.5%;
Component C:Genistein 0.1-0.4%, forulic acid 0.01-0.05%, ligustilide 0.01-0.05%, glycerine 1-7%;
Balance of deionized water, adds up to 100%.
2. natural anti-aging cosmetics according to claim 1, it is characterised in that by the raw material system of following percentage by weight
It is standby to form:
Component A:Jojoba oil 5%, isopropyl palmitate 1.0%, polyacrylamide 0.6%, bisabolol 0.1%, azone
0.1%th, Alkyl Polyglycoside of Hexadecyl 2.5%, glycerin monostearate 1%;
B component:Sodium Hyaluronate 3.0%, methyl hydroxybenzoate 0.2%, amino acid humectant 2.0%, 1,3- dihydroxymethyl -5,5-
Dimethyl hydantoin 0.1%;
Component C:Genistein 0.2%, forulic acid 0.02%, ligustilide 0.02%, glycerine 3.0%;
Balance of deionized water, adds up to 100%.
3. a kind of natural anti-aging cosmetics, it is characterised in that be prepared from by the raw material of following percentage by weight:
Component A:Jojoba oil 2-8%, isopropyl palmitate 0.5-4%, polyacrylamide 0.2-4%, bisabolol 0.01-
0.5%th, azone 0.01-0.5%, Alkyl Polyglycoside of Hexadecyl 1-6%, glycerin monostearate 1-7%;
B component:Sodium Hyaluronate 1-5%, methyl hydroxybenzoate 0.2-0.4%, amino acid humectant 0.5-5%, 1,3- dihydroxy first
Base -5,5- dimethyl hydantoin 0.2-0.5%;
Component C:Genistein, 0.1-0.4%, angelica extract 0.5-2.0%, glycerine 1-7%;
Balance of deionized water, adds up to 100%;
Containing forulic acid and ligustilide wherein in angelica extract.
4. natural anti-aging cosmetics according to claim 3, it is characterised in that by the raw material system of following percentage by weight
It is standby to form:
Component A:Jojoba oil 5%, isopropyl palmitate 1.0%, polyacrylamide 0.6%, bisabolol 0.1%, azone
0.1%th, Alkyl Polyglycoside of Hexadecyl 2.5%, glycerin monostearate 1%;
B component:Sodium Hyaluronate 3.0%, methyl hydroxybenzoate 0.2%, amino acid humectant 2.0%, 1,3- dihydroxymethyl -5,5-
Dimethyl hydantoin 0.1%;
Component C:Genistein 0.2%, angelica extract 2.0%, glycerine 3.0%;
Balance of deionized water, adds up to 100%.
5. natural anti-aging cosmetics according to any one of claim 1-4, it is characterised in that the cosmetics are mainly fitted
For postclimacteric old women.
6. a kind of preparation method of the natural anti-aging cosmetics as described in any one of claim 1-4, it is characterised in that include
Following steps:
S1:All raw materials of component A are heated into 80-90 DEG C in beaker, I phases are stirred to after being completely dissolved to obtain;
S2:All raw materials of B component are added one by one in deionized water, 80-90 DEG C is heated to, is stirred to after being completely dissolved and is obtained II
Phase;
S3:II is added in I phases, with homogenizer homogeneous 1-5min, stirring is cooled to 40 DEG C, adds component C, stirs to mixing
It is uniform.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201611237337.XA CN106619223B (en) | 2016-12-28 | 2016-12-28 | A kind of natural anti-aging cosmetics and preparation method thereof |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201611237337.XA CN106619223B (en) | 2016-12-28 | 2016-12-28 | A kind of natural anti-aging cosmetics and preparation method thereof |
Publications (2)
Publication Number | Publication Date |
---|---|
CN106619223A true CN106619223A (en) | 2017-05-10 |
CN106619223B CN106619223B (en) | 2019-11-29 |
Family
ID=58831994
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN201611237337.XA Active CN106619223B (en) | 2016-12-28 | 2016-12-28 | A kind of natural anti-aging cosmetics and preparation method thereof |
Country Status (1)
Country | Link |
---|---|
CN (1) | CN106619223B (en) |
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN108309848A (en) * | 2018-03-27 | 2018-07-24 | 上海清轩生物科技有限公司 | The preparation method and its anti-apolexis composition of chlorella extract |
CN108338950A (en) * | 2018-03-27 | 2018-07-31 | 上海清轩生物科技有限公司 | With stablizing the anti-apolexis composition and application thereof for being adhered effect between epidermis and corium |
CN108652991A (en) * | 2018-05-25 | 2018-10-16 | 珀莱雅化妆品股份有限公司 | A kind of preparation method of the composition with smooth skin effect |
CN109646317A (en) * | 2018-12-29 | 2019-04-19 | 肇庆巧巧日用化工有限公司 | Preparation method of moisturizing cream for chest skin |
Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101234132A (en) * | 2007-01-31 | 2008-08-06 | 成都彩子化妆品有限公司 | New use of angelica sinensis or its extract in preparing skin care products |
CN104107159A (en) * | 2014-06-27 | 2014-10-22 | 陈海 | Cosmetic and preparation method thereof |
CN105106071A (en) * | 2015-09-15 | 2015-12-02 | 湖北穆兰同大科技有限公司 | Anti-wrinkle skin care product and preparation method thereof |
CN105193653A (en) * | 2015-09-15 | 2015-12-30 | 湖北穆兰同大科技有限公司 | Angelica sinensis anti-wrinkle cream and preparation method thereof |
CN105687031A (en) * | 2016-02-01 | 2016-06-22 | 东莞品派实业投资有限公司 | Total-effect multifunctional moisturizing cream and preparation method thereof |
CN105832568A (en) * | 2016-03-26 | 2016-08-10 | 佛山市芊茹化妆品有限公司 | Solid micro-emulsion, preparation method and application thereof |
-
2016
- 2016-12-28 CN CN201611237337.XA patent/CN106619223B/en active Active
Patent Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101234132A (en) * | 2007-01-31 | 2008-08-06 | 成都彩子化妆品有限公司 | New use of angelica sinensis or its extract in preparing skin care products |
CN104107159A (en) * | 2014-06-27 | 2014-10-22 | 陈海 | Cosmetic and preparation method thereof |
CN105106071A (en) * | 2015-09-15 | 2015-12-02 | 湖北穆兰同大科技有限公司 | Anti-wrinkle skin care product and preparation method thereof |
CN105193653A (en) * | 2015-09-15 | 2015-12-30 | 湖北穆兰同大科技有限公司 | Angelica sinensis anti-wrinkle cream and preparation method thereof |
CN105687031A (en) * | 2016-02-01 | 2016-06-22 | 东莞品派实业投资有限公司 | Total-effect multifunctional moisturizing cream and preparation method thereof |
CN105832568A (en) * | 2016-03-26 | 2016-08-10 | 佛山市芊茹化妆品有限公司 | Solid micro-emulsion, preparation method and application thereof |
Non-Patent Citations (1)
Title |
---|
高斌等: "大豆异黄酮与皮肤美容", 《中国化妆品》 * |
Cited By (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN108309848A (en) * | 2018-03-27 | 2018-07-24 | 上海清轩生物科技有限公司 | The preparation method and its anti-apolexis composition of chlorella extract |
CN108338950A (en) * | 2018-03-27 | 2018-07-31 | 上海清轩生物科技有限公司 | With stablizing the anti-apolexis composition and application thereof for being adhered effect between epidermis and corium |
CN108338950B (en) * | 2018-03-27 | 2020-04-24 | 上海清轩生物科技有限公司 | Anti-aging composition with function of stabilizing adhesion between epidermis and dermis and application thereof |
CN108309848B (en) * | 2018-03-27 | 2020-08-04 | 上海清轩生物科技有限公司 | Preparation method of chlorella extract and anti-aging composition thereof |
CN108652991A (en) * | 2018-05-25 | 2018-10-16 | 珀莱雅化妆品股份有限公司 | A kind of preparation method of the composition with smooth skin effect |
CN109646317A (en) * | 2018-12-29 | 2019-04-19 | 肇庆巧巧日用化工有限公司 | Preparation method of moisturizing cream for chest skin |
Also Published As
Publication number | Publication date |
---|---|
CN106619223B (en) | 2019-11-29 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CN105687055B (en) | A kind of eye maintenance Essence and preparation method thereof | |
CN111529417B (en) | Repairing eye cream with blue light resisting effect and preparation method thereof | |
CN106619223B (en) | A kind of natural anti-aging cosmetics and preparation method thereof | |
CN105534796B (en) | A kind of antiallergy toner containing Folium Artemisiae Argyi extract and preparation method thereof | |
TW200812638A (en) | Compositions comprising kakadu plum extract or acai berry extract | |
CN110279599B (en) | Whitening composition, set containing whitening composition and preparation method of set | |
CN105168054A (en) | Mask capable of supplementing water, whitening and removing wrinkles and preparation method of mask | |
CN107308057B (en) | Nontoxic hair softening cream capable of softening and nourishing hair and preparation method thereof | |
CN105662899A (en) | Skincare product having functions of repairing scar and resisting wrinkle and preparation method thereof | |
CN118001205B (en) | Anti-wrinkle active composition and application thereof, and anti-wrinkle cream | |
CN109044941B (en) | Skin firming, nourishing and moisturizing composition and preparation method and application thereof | |
CN114376949B (en) | Essence mask and preparation method and application thereof | |
CN103494719B (en) | Preparation method of anti-aging cream | |
CN113413355A (en) | Eye cream with instant brightening and wrinkle reducing effects and preparation method thereof | |
CN108354863A (en) | A kind of Shu Min remediation compositions | |
CN113171309B (en) | Whitening and moisturizing cosmetic composition containing phloretin as well as preparation and application thereof | |
CN110664643A (en) | Polypeptide essence with multiple-effect whitening effect and preparation method thereof | |
CN110433123A (en) | A kind of composite skin care product for having effects that repair | |
CN110559195A (en) | Mask powder with whitening and anti-aging functions and preparation method thereof | |
CN110302128A (en) | A kind of whitening antiallergic rich in natural product extraction ingredient is releived sleep mask and preparation method thereof | |
CN112516066B (en) | Oil control composition and application thereof in cosmetics | |
CN104188859B (en) | A kind of crease-resistant skin care emulsion containing natural component extract and preparation method thereof | |
CN109453056A (en) | A kind of moisture saver mask liquid and preparation method thereof | |
CN107854358A (en) | A kind of anti-apolexis composition and the skin care item containing said composition | |
CN113440468A (en) | Skin conditioner compound for whitening and brightening skin, novel skin cream and preparation method thereof |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
PB01 | Publication | ||
PB01 | Publication | ||
SE01 | Entry into force of request for substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
TA01 | Transfer of patent application right | ||
TA01 | Transfer of patent application right |
Effective date of registration: 20190214 Address after: 150040 24 Heping Road, Xiangfang District, Harbin, Heilongjiang. Applicant after: Heilongjiang University of Chinese Medicine Address before: 154007 Guanghua Street, Qianjin District, Jiamusi, Heilongjiang 39 Applicant before: Li Lingxia |
|
GR01 | Patent grant | ||
GR01 | Patent grant |