CN106618811A - Functional bionic artificial cervical disc - Google Patents

Functional bionic artificial cervical disc Download PDF

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Publication number
CN106618811A
CN106618811A CN201710096703.2A CN201710096703A CN106618811A CN 106618811 A CN106618811 A CN 106618811A CN 201710096703 A CN201710096703 A CN 201710096703A CN 106618811 A CN106618811 A CN 106618811A
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CN
China
Prior art keywords
nucleus pulposus
boss
artificial disc
rigid endplate
groove
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Granted
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CN201710096703.2A
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Chinese (zh)
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CN106618811B (en
Inventor
孟阳
冯巧芳
姜秀娟
张立群
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Beijing University of Chemical Technology
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Wuxi Baolai Fu Medical Instrument Ltd Co
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Priority to CN201710096703.2A priority Critical patent/CN106618811B/en
Publication of CN106618811A publication Critical patent/CN106618811A/en
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02Prostheses implantable into the body
    • A61F2/30Joints
    • A61F2/44Joints for the spine, e.g. vertebrae, spinal discs
    • A61F2/442Intervertebral or spinal discs, e.g. resilient
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02Prostheses implantable into the body
    • A61F2/30Joints
    • A61F2002/30001Additional features of subject-matter classified in A61F2/28, A61F2/30 and subgroups thereof
    • A61F2002/30003Material related properties of the prosthesis or of a coating on the prosthesis
    • A61F2002/30004Material related properties of the prosthesis or of a coating on the prosthesis the prosthesis being made from materials having different values of a given property at different locations within the same prosthesis
    • A61F2002/30014Material related properties of the prosthesis or of a coating on the prosthesis the prosthesis being made from materials having different values of a given property at different locations within the same prosthesis differing in elasticity, stiffness or compressibility

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  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Cardiology (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Transplantation (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Prostheses (AREA)

Abstract

The invention relates to a functional bionic artificial cervical disc, which comprises an upper rigid end plate, a lower rigid end plate and nucleus pulposus which is arranged between the upper rigid end plate and the lower rigid end plate, wherein a hollow ring is arranged at the outer side of the nucleus pulposus; in correspondence to the hollow ring, an upper convex part, which is perpendicularly inserted and clamped in the hollow ring, is arranged on the upper rigid end plate and a lower convex part, which is perpendicularly inserted and clamped in the hollow ring, is arranged on the lower rigid end plate; a first groove, in correspondence to a contact surface of the upper rigid end plate, is formed in the middle of the nucleus pulposus and a second groove, in correspondence to a contact surface of the lower rigid end plate, is formed in the middle of the nucleus pulposus; a first boss is arranged on the upper rigid end plate, and correspondingly, a second boss is arranged on the lower rigid end plate; and a transition layer is arranged between the nucleus pulposus and the upper rigid end plate and a transition layer is arranged between the nucleus pulposus and the lower rigid end plate. The artificial cervical disc provided by the invention is capable of doing activities of rotation, inflexion-extension and lateral bending within a three-dimensional space by six degrees of freedom, so as to achieve movement functions of normal cervical disc in a human body; and in addition, the functional bionic artificial cervical disc is excellent in biomechanic adaptability.

Description

A kind of function bionicses type cervical artificial disc
Technical field
The present invention relates to a kind of function bionicses type cervical artificial disc, belongs to medical embedded property orthopedic medical device field skill Art field.
Background technology
Cervical spondylosis are a kind of common disease and frequently-occurring disease, and according to statistics the current cervical spondylosis patients of China are up to 50,000,000 People, the process and the quickening of modern life rhythm with aging, the incidence of disease of China's cervical intervertebral disk disease rises year by year.In neck In the treatment therapeutic method of surgery of disc disease, cervical artificial disc displacement is considered as that a kind of very forward position is effectively treated Method, this method can be replaced original interverbebral disc and exercised its function by being implanted into one in intervertenral space with the device of activity, Realize retaining the motor function of cervical vertebra motion, while providing the stability required for cervical vertebra, prevent and delay adjacent phases regression Occurrence and development, so as to reach the purpose for the treatment of.
Have more than ten kind cervical intervertebral disk prosthesis listings in the world at present or Jing FDA approvals enter clinical stage, and at home, There is no the cervical intervertebral disk prosthesis launch of independent research.At present major part cervical intervertebral disk prosthesis are set using the sliding structure of ball-and-socket Meter, such as the intervertebral disk prosthesis disclosed in A etc. of A, CN 101961270 of patent CN 102648879, this hard support mechanical characteristic with The perfect structure of human cervical spine disk and mechanics sex character difference are larger, not with elasticity, can not protect well when being shaken Cervical vertebra protective, and there is certain abrasive dust hidden danger in Long-Time Service, surrounding tissue is impacted.Human cervical spine disk essence On be a kind of resilient structure of tool, it is clear that the sliding friction structure of traditional hard support can not be simulated well between human cervical spine The structure and activity characteristic of disk.In the last few years, the research for beginning with some resilient artificial disc after arthroplasty of tool occurs, but still There are problems that, the generation of the chip that on the one hand remains difficult to avoid to rub, on the other hand its biomechanics characteristic is being still with human body just Often cervical intervertebral disk differs greatly.The clinical practice of multiclass cervical artificial disc product shows, cervical artificial disc is displaced After the human cervical spine disk of pathology, good therapeutic effect can be reached, but due to the biomechanics characteristic of cervical artificial disc With differing greatly for human normal disk, after implantation human body, being implanted into the mobility of the cervical vertebra of sections can significantly increase, adjacent little Guan The stress of section and ligament increases, and after the implantation long period, raising occurs in the ectopic ossification incidence for being implanted into sections.Therefore exploitation one Plant biomechanics characteristic to produce with the function bionicses type cervical artificial disc without friction-type that human normal cervical intervertebral disk is more nearly Product, have great importance for the development of cervical artificial disc replacement and the treatment of cervical spondylosis is promoted.
The content of the invention
The invention aims to solve the above problems, there is provided a kind of simple structure, function bionicses compact to design Type cervical artificial disc.
The present invention is adopted the following technical scheme that:A kind of function bionicses type cervical artificial disc, including upper rigid endplate, it is lower just Property soleplate and the nucleus pulposus being arranged between rigid endplate and lower rigid endplate, are provided with hollow circle, institute on the outside of the nucleus pulposus State the hollow circle of rigid endplate correspondence and be provided with the upper projecting portion for being inserted perpendicularly into and being fastened in hollow circle, the lower rigid endplate The hollow circle of correspondence is provided with the lower convex portion for being inserted perpendicularly into and being fastened in hollow circle, and the middle part of the nucleus pulposus corresponds to respectively above just Property soleplate and the contact surface of lower rigid endplate be provided with the first groove and the second groove, the first groove of the upper rigid endplate correspondence First boss is provided with, the second groove of the lower rigid endplate correspondence is provided with second boss, the nucleus pulposus and upper rigid endplate Between be provided with transition zone, lower transition zone, the upper rigid endplate and lower rigidity are provided between the nucleus pulposus and lower rigid endplate The angle β of the rear and front end of soleplate is in 2-8 °.
Further, the first boss, the cross section of second boss are circular or rectangle, the first boss, second Portion cross-sectional area of the boss in the first groove, the second groove gradually increases or reduces or constant.
Further, arrange fluted on the cross section of the first boss and second boss.
Further, filled with the low modulus of elasticity materials that elastic modelling quantity is 0.1 ~ 2MPa in the hollow circle.
Further, be provided with the side that the upper transition zone and lower transition zone contact with nucleus pulposus several grooves, Hole or pit.
Further, the cross-sectional area of first groove and the second groove is 10 ~ 40mm2
Further, the distance that hollow circle is arrived in the two ends outside of the nucleus pulposus is 0.2 ~ 2mm.
Further, first groove and the second groove are surrounded and formed by first raised, the second projection and nucleus pulposus body, It is arc-shaped connection or right angle connection between first projection and the second projection and nucleus pulposus body, nucleus pulposus body middle part is provided with Plus thick portion.
Further, the described first raised and the second projection end is in tip-shape or flat.
The invention has the advantages that:(1)Cervical artificial disc elasticity is non-hard support slide construction, by the bullet of nucleus pulposus Property deformation effectively realize cervical artificial disc rotating, bend and stretch, the activity in lateral bending three-dimensional six-freedom degree space;(2)Biological Strength Learn characteristic close with human normal interverbebral disc, after implantation human body, can preferably rebuild human cervical spine biomethanics;(3)People The rigid endplate of work cervical intervertebral disk is combined with nucleus pulposus close and firm, there is no frictional interface, effectively reduces or eliminate rigid endplate The abrasive dust hidden danger caused because of interface friction with nucleus pulposus;(4)The surface that upper and lower rigid endplate is contacted with vertebra adopts and vertebral surface Approximate profile design is good with the identical property of human vertebrae after implantation with the angle of inclination close with human body intervertenral space.
Description of the drawings
Fig. 1 is the structural representation of the present invention.
Fig. 2 is the structural representation of the first boss of cervical artificial disc in the present invention.
Fig. 3 is the schematic diagram of upper transition zone in the present invention.
Fig. 4 is the schematic diagram of cervical artificial disc nucleus pulposus different structure in the present invention.
Fig. 5 is, by the cervical artificial disc implantation vertebra in Fig. 4, to apply the mobility feelings produced after identical torque Condition.
Reference:Upper rigid endplate 1, lower rigid endplate 2, nucleus pulposus 3, hollow circle 4, upper projecting portion 5, lower convex portion 6, the One groove 7, the second groove 8, first boss 9, second boss 10, upper transition zone 11, lower transition zone 12, the first projection 13, second Raised 14, nucleus pulposus body 15.
Specific embodiment
Below in conjunction with accompanying drawing, the invention will be further described.
As shown in figure 1, a kind of function bionicses type cervical artificial disc, including upper rigid endplate 1, lower rigid endplate 2 and set The nucleus pulposus 3 being placed between rigid endplate 1 and lower rigid endplate 2, the outside of nucleus pulposus 3 is provided with hollow circle 4, upper rigid endplate 1 The hollow circle 4 of correspondence is provided with the upper projecting portion 5 for being inserted perpendicularly into and being fastened in hollow circle 4, and the lower correspondence of rigid endplate 2 is hollow to enclose 4 Be provided with the lower convex portion 6 being inserted perpendicularly into and be fastened in hollow circle 4, the middle part of nucleus pulposus 3 correspond to respectively upper rigid endplate 1 and under The contact surface of rigid endplate 2 is provided with the first groove 7 and the second groove 8, and the first groove 7 of correspondence of upper rigid endplate 1 is provided with the One boss 9, second groove 8 of the lower correspondence of rigid endplate 2 is provided with second boss 10, is provided between nucleus pulposus 3 and upper rigid endplate 1 Transition zone 11, is provided with lower transition zone 12, before and after upper rigid endplate 1 and lower rigid endplate 2 between nucleus pulposus 3 and lower rigid endplate 2 The angle β at two ends is in 2-8 °.
First boss 9, the cross section of second boss 10 are circular or rectangle, and first boss 9, second boss 10 are recessed first Portion cross-sectional area in groove 7, the second groove 7 gradually increases or reduces or constant, first boss 9 and second boss 10 it is transversal Arrange on face fluted.It is illustrated in figure 2 the structural representation of the first boss 9 of cervical artificial disc in the present invention.First is convex The cross-sectional area of platform 9 gradually increases to the inside of nucleus pulposus(2-1,2-3,2-4,2-5)Or reduce(2-2)Or be basically unchanged(2-6), it is horizontal The shape of sectional area is rounded(2-1,2-2)Or rectangle(2-3,2-4,2-5,2-6), the knot such as groove is additionally provided with first boss 9 Structure(2-5,2-6).The structure design of first boss 9, can reach the elastic deformation for adjusting cervical artificial disc under external force load, It is allowed to the effect of the more biomechanics characteristic of matching normal human's cervical intervertebral disk.
Under the conditions of same load is born, the deformation of nucleus pulposus 3 has important relationship with the internal geometry of nucleus pulposus, leads to Thickness, the cross-sectional area of the material of nucleus pulposus center are overregulated, the performance of nucleus pulposus can be adjusted so that by extraneous load When, produce the activity similar to human cervical spine disk.In the periphery of nucleus pulposus 3 containing hollow circle 4, internal non-filler or filling one Circle elastomeric material, the elastic modelling quantity of the elastomeric material filled in the range of 0.1 ~ 2MPa, the hollow structure of hollow circle 4 Design, mainly ensures that cervical artificial disc when by extraneous load, can be relatively easy to activity, while passing through hollow knot The adjustment of structure physical dimension and internal possible filler, has cervical artificial disc appropriate close with human cervical spine disk Activity.The thickness of the material that the outside of nucleus pulposus 3 is arrived between hollow circle is in the range of 0.2 ~ 2mm.The side of setting one of this structure Face can adjust the activity of cervical artificial disc, on the other hand prevent the filler abjection of inside.
Several grooves, hole or recessed are provided with the side that upper transition zone 11 and lower transition zone 12 contact with nucleus pulposus 3 Hole.Enter when nucleus pulposus 3 is molded in pit, micropore, with rigid endplate strong bonded is formed, in cervical artificial disc activity, keep away Exempt from, because interfacial separation produces frictional interface, to cause abrasive dust to produce.As shown in figure 3, for the schematic diagram of upper transition zone, in upper rigidity eventually The side that plate contacts with nucleus pulposus, is provided with one layer of upper transition zone, can and nucleus pulposus form the combination of close and firm.Upper transition zone In containing by machining process formation groove structure(3-1), or containing the hole knot formed by spraying bead particles Structure(3-2), or the pit containing a large amount of uniform micron-scales(3-3).It is integrally formed with upper and lower rigid endplate in nucleus material During, nucleus material is full of in above-mentioned groove, hole, bowl configurations, and rigid endplate realizes the combination of close and firm.
The upper and lower rigid endplate of cervical artificial disc is set with the surface that vertebra is contacted using the profile approximate with vertebral surface Meter, the thickness of the upper and lower rigid endplate being implanted into after human body on rear side of human body is less than the thickness on front side of human body, artificial cervical Both sides are in 2-8 ° of angle before and after disk.Normal human's cervical intervertebral disk itself is presented certain angle, and the product in the present invention exists The angle close with human cervical spine disk is provided with during design, it is ensured that after implantation, cervical artificial disc can good match it is upper and lower Vertebra, makes product realize more preferably function bionicses effect.
Convex thorn structure is provided with the face that the upper and lower rigid endplate of cervical artificial disc is contacted with human vertebrae, and is sprayed There is one layer of titanium and hydroxyapatite coating layer beneficial to bone apposition growth.Ensure cervical artificial disc tool after cervical artificial disc implantation There is the osseointegration character in good Initial stability and later stage, it is to avoid the feelings of cervical artificial disc abjection occur in use Condition.
The geomery of the groove of nucleus pulposus first and the second groove is by first boss and the shape chi of second boss in the present invention Very little decision.Cervical artificial disc is presented in nucleus material and is flowed using nucleus pulposus and the integrally formed method of upper and lower rigid endplate During the mould for being placed with rigid endplate is injected into during state, then nucleus material is molded full of in rigid endplate, forms institute The elastic nucleus pulposus division center of design.
As shown in figure 4, for the schematic diagram of cervical artificial disc nucleus pulposus different structure in the present invention, the first groove and second recessed Groove is surrounded and formed by first raised, the second projection and nucleus pulposus body, is circular arc between the first projection and the second projection and nucleus pulposus body Shape connects(4-1、4-5)Or right angle connection(4-2、4-3、4-4), nucleus pulposus body middle part is provided with plus thick portion(4-3), first is convex Rise and the end of the second projection is in tip-shape(4-1、4-5)Or flat(4-2、4-3、4-4), wherein the first groove and second recessed The structure of groove is different, and in the first hollow circle and the second hollow circle low modulus elastomeric material is filled(4-4)Or non-filler(4- 1、4-2、4-3、4-5), the thickness difference in nucleus pulposus outside to hollow circle.Being designed to of these structures reaches regulation artificial cervical The effect of the mechanical characteristic of disk.
As shown in figure 5, being, by all kinds of cervical artificial disc implantation vertebras in Fig. 4, to apply what is produced after identical torque Mobility situation.Biomechanics characteristic between existing cervical artificial disc product and normal human's cervical vertebra still suffers from larger difference Away from existing product can cause the mobility for being implanted into sections after implantation human body(As before and after lateroflexion stretch, the work of lateral bending, torsional direction Dynamic degree)Substantially increase, so as to the ligament tissue that causes to be implanted into around sections, articular facets stress are excessive, cause various clinics to ask Topic.From the result in Fig. 5, the cervical artificial disc being related in the present invention is respectively provided with similar to human normal cervical intervertebral disk Biomechanics characteristic, after implantation human body, before being implanted into the mobility of sections and being implanted into(Normal human's cervical intervertebral disk)Mobility Difference less, can well rebuild the biomethanics of human cervical spine, with good function bionicses performance.All kinds of people in Fig. 4 In work cervical intervertebral disk structure mainly in nucleus pulposus central recess structure, hollow structure, hollow structure between filler design, groove There is certain difference in the aspects such as nucleus material thickness so that final mobility has certain difference, illustrate present invention product These special construction designs in product, can effectively adjust the biomechanics characteristic of cervical artificial disc, be allowed to be close to well The biomethanics of human cervical spine disk.

Claims (9)

1. a kind of function bionicses type cervical artificial disc, including upper rigid endplate(1), lower rigid endplate(2)And be arranged at just Property soleplate(1)With lower rigid endplate(2)Between nucleus pulposus(3), it is characterised in that:The nucleus pulposus(3)Outside be provided with it is hollow Circle(4), the upper rigid endplate(1)The hollow circle of correspondence(4)It is provided with the upper projecting portion being inserted perpendicularly into and be fastened in hollow circle (5), the lower rigid endplate(2)The hollow circle of correspondence(4)It is provided with and is inserted perpendicularly into and is fastened on hollow circle(4)In lower convex portion (6), the nucleus pulposus(3)Middle part correspond to upper rigid endplate respectively(1)With lower rigid endplate(2)Contact surface to be provided with first recessed Groove(7)With the second groove(8), the upper rigid endplate(1)The first groove of correspondence(7)It is provided with first boss(9), it is described lower firm Property soleplate(2)The second groove of correspondence(8)It is provided with second boss(10), the nucleus pulposus(3)With upper rigid endplate(1)Between be provided with Upper transition zone(11), the nucleus pulposus(3)With lower rigid endplate(2)Between be provided with lower transition zone(12), the upper rigid endplate(1) With lower rigid endplate(2)Rear and front end angle β be in 2-8 °.
2. function bionicses type cervical artificial disc as claimed in claim 1, it is characterised in that:The first boss(9), second Boss(10)Cross section be circular or rectangle, the first boss(9), second boss(10)In the first groove(7), it is second recessed Groove(8)Interior portion cross-sectional area gradually increases or reduces or constant.
3. function bionicses type cervical artificial disc as claimed in claim 2, it is characterised in that:The first boss(9)With Two boss(10)Cross section on arrange fluted.
4. function bionicses type cervical artificial disc as claimed in claim 1, it is characterised in that:The hollow circle(4)Middle filling Flexible modulus is the low modulus of elasticity materials of 0.1 ~ 2MPa.
5. function bionicses type cervical artificial disc as claimed in claim 1, it is characterised in that:The upper transition zone(11)With under Transition zone(12)With nucleus pulposus(3)Several grooves, hole or pit are provided with the side for contacting.
6. function bionicses type cervical artificial disc as claimed in claim 1, it is characterised in that:First groove(7)With Two grooves(8)Cross-sectional area be 10 ~ 40mm2
7. function bionicses type cervical artificial disc as claimed in claim 1, it is characterised in that:The nucleus pulposus(3)Two ends outside Side is to hollow circle(4)Distance be 0.2 ~ 2mm.
8. function bionicses type cervical artificial disc as claimed in claim 1, it is characterised in that:First groove(7)With Two grooves(8)It is raised by first(13), it is second raised(14)With nucleus pulposus body(15)Surround and formed, described first is raised(13)With Second is raised(14)It is that arc-shaped is connected or right angle connection between nucleus pulposus body, nucleus pulposus body(15)Middle part is provided with overstriking Portion.
9. function bionicses type cervical artificial disc as claimed in claim 9, it is characterised in that:Described first is raised(13)With Two is raised(14)End be in tip-shape or flat.
CN201710096703.2A 2017-02-22 2017-02-22 A kind of function bionics type cervical artificial disc Active CN106618811B (en)

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2021179628A1 (en) * 2020-03-09 2021-09-16 山东冠龙医疗用品有限公司 Intervertebral disc fusion cage

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EP2641571A1 (en) * 2004-06-30 2013-09-25 Synergy Disc Replacement Inc. Artificial spinal disc
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CN105534623A (en) * 2016-01-12 2016-05-04 四川大学华西医院 Bionic artificial intervertebral disc
CN105708584A (en) * 2016-01-18 2016-06-29 无锡宝通医疗投资有限公司 Integral bionic cervical disc prosthesis
CN106236334A (en) * 2016-09-30 2016-12-21 深圳清华大学研究院 Artificial cervical intervertebral disk prosthesis

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Publication number Priority date Publication date Assignee Title
EP2641571A1 (en) * 2004-06-30 2013-09-25 Synergy Disc Replacement Inc. Artificial spinal disc
US20070250168A1 (en) * 2004-12-28 2007-10-25 Beat Lechmann Modular intervertebral implant
CN201108513Y (en) * 2007-10-30 2008-09-03 冠亚国际科技股份有限公司 Spondyle filling blocks
KR20090118365A (en) * 2008-05-13 2009-11-18 윤강준 Intervertebral disc prosthesis
CN202027749U (en) * 2011-04-01 2011-11-09 北京化工大学 Integral artificial intervertebral disc
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CN204951241U (en) * 2015-07-10 2016-01-13 北京中安泰华科技有限公司 Kidney shape cervical vertebra intervertebral disc system
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CN105708584A (en) * 2016-01-18 2016-06-29 无锡宝通医疗投资有限公司 Integral bionic cervical disc prosthesis
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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2021179628A1 (en) * 2020-03-09 2021-09-16 山东冠龙医疗用品有限公司 Intervertebral disc fusion cage

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