CN106535911B - 含有作为活性成分的桑白皮提取物与卫矛提取物的牙周炎预防及治疗用口腔组合物 - Google Patents
含有作为活性成分的桑白皮提取物与卫矛提取物的牙周炎预防及治疗用口腔组合物 Download PDFInfo
- Publication number
- CN106535911B CN106535911B CN201680000808.7A CN201680000808A CN106535911B CN 106535911 B CN106535911 B CN 106535911B CN 201680000808 A CN201680000808 A CN 201680000808A CN 106535911 B CN106535911 B CN 106535911B
- Authority
- CN
- China
- Prior art keywords
- extract
- cortex mori
- preventing
- aqueous extract
- euonymus
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 239000000203 mixture Substances 0.000 title claims abstract description 47
- 201000001245 periodontitis Diseases 0.000 title claims abstract description 29
- 239000004480 active ingredient Substances 0.000 title claims abstract description 21
- 241000208368 Euonymus alatus Species 0.000 title claims description 34
- 239000000284 extract Substances 0.000 title abstract description 115
- 208000028169 periodontal disease Diseases 0.000 claims abstract description 13
- 235000013376 functional food Nutrition 0.000 claims abstract description 9
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 37
- 241000605862 Porphyromonas gingivalis Species 0.000 claims description 21
- 241000894006 Bacteria Species 0.000 claims description 11
- 239000000606 toothpaste Substances 0.000 claims description 9
- 229940034610 toothpaste Drugs 0.000 claims description 9
- 239000003814 drug Substances 0.000 claims description 8
- 239000000843 powder Substances 0.000 claims description 8
- 235000013361 beverage Nutrition 0.000 claims description 7
- 230000002401 inhibitory effect Effects 0.000 claims description 7
- 210000000214 mouth Anatomy 0.000 claims description 7
- 244000052616 bacterial pathogen Species 0.000 claims description 4
- 235000015218 chewing gum Nutrition 0.000 claims description 4
- 239000002775 capsule Substances 0.000 claims description 3
- 229940112822 chewing gum Drugs 0.000 claims description 3
- 239000008187 granular material Substances 0.000 claims description 3
- 238000004519 manufacturing process Methods 0.000 claims description 3
- 239000002324 mouth wash Substances 0.000 claims description 3
- 239000003826 tablet Substances 0.000 claims description 3
- 239000003599 detergent Substances 0.000 claims description 2
- 239000000668 oral spray Substances 0.000 claims description 2
- 229940041678 oral spray Drugs 0.000 claims description 2
- 239000006286 aqueous extract Substances 0.000 claims 8
- 229940126701 oral medication Drugs 0.000 claims 1
- 230000000694 effects Effects 0.000 abstract description 17
- 241001262617 Japonica Species 0.000 abstract 1
- 230000000844 anti-bacterial effect Effects 0.000 description 25
- 240000000249 Morus alba Species 0.000 description 18
- 235000008708 Morus alba Nutrition 0.000 description 18
- -1 octyl Methyl salicylate (Methyl salicylate) Chemical compound 0.000 description 12
- 239000000796 flavoring agent Substances 0.000 description 10
- 244000005700 microbiome Species 0.000 description 8
- 241000208367 Euonymus Species 0.000 description 7
- 235000013305 food Nutrition 0.000 description 7
- 239000011734 sodium Substances 0.000 description 7
- 229910052708 sodium Inorganic materials 0.000 description 7
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 7
- 235000019634 flavors Nutrition 0.000 description 6
- 238000002156 mixing Methods 0.000 description 6
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 5
- 230000001580 bacterial effect Effects 0.000 description 5
- 235000014113 dietary fatty acids Nutrition 0.000 description 5
- 239000000194 fatty acid Substances 0.000 description 5
- 229930195729 fatty acid Natural products 0.000 description 5
- 244000052769 pathogen Species 0.000 description 5
- 239000000243 solution Substances 0.000 description 5
- 208000010266 Aggressive Periodontitis Diseases 0.000 description 4
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 4
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 4
- 239000011230 binding agent Substances 0.000 description 4
- 239000003795 chemical substances by application Substances 0.000 description 4
- 208000002925 dental caries Diseases 0.000 description 4
- 239000012153 distilled water Substances 0.000 description 4
- RRAFCDWBNXTKKO-UHFFFAOYSA-N eugenol Chemical compound COC1=CC(CC=C)=CC=C1O RRAFCDWBNXTKKO-UHFFFAOYSA-N 0.000 description 4
- 235000013355 food flavoring agent Nutrition 0.000 description 4
- KWIUHFFTVRNATP-UHFFFAOYSA-N glycine betaine Chemical compound C[N+](C)(C)CC([O-])=O KWIUHFFTVRNATP-UHFFFAOYSA-N 0.000 description 4
- XMGQYMWWDOXHJM-UHFFFAOYSA-N limonene Chemical compound CC(=C)C1CCC(C)=CC1 XMGQYMWWDOXHJM-UHFFFAOYSA-N 0.000 description 4
- CDOSHBSSFJOMGT-UHFFFAOYSA-N linalool Chemical compound CC(C)=CCCC(C)(O)C=C CDOSHBSSFJOMGT-UHFFFAOYSA-N 0.000 description 4
- 239000007788 liquid Substances 0.000 description 4
- 239000003921 oil Substances 0.000 description 4
- 235000019198 oils Nutrition 0.000 description 4
- 201000006727 periodontosis Diseases 0.000 description 4
- 238000002360 preparation method Methods 0.000 description 4
- 238000012360 testing method Methods 0.000 description 4
- MGSRCZKZVOBKFT-UHFFFAOYSA-N thymol Chemical compound CC(C)C1=CC=C(C)C=C1O MGSRCZKZVOBKFT-UHFFFAOYSA-N 0.000 description 4
- GHXZTYHSJHQHIJ-UHFFFAOYSA-N Chlorhexidine Chemical compound C=1C=C(Cl)C=CC=1NC(N)=NC(N)=NCCCCCCN=C(N)N=C(N)NC1=CC=C(Cl)C=C1 GHXZTYHSJHQHIJ-UHFFFAOYSA-N 0.000 description 3
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 description 3
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 3
- 239000003945 anionic surfactant Substances 0.000 description 3
- 239000008280 blood Substances 0.000 description 3
- 210000004369 blood Anatomy 0.000 description 3
- 150000001720 carbohydrates Chemical class 0.000 description 3
- 235000014633 carbohydrates Nutrition 0.000 description 3
- 229960003260 chlorhexidine Drugs 0.000 description 3
- 229940079593 drug Drugs 0.000 description 3
- 235000003599 food sweetener Nutrition 0.000 description 3
- 235000013402 health food Nutrition 0.000 description 3
- 239000003906 humectant Substances 0.000 description 3
- 239000004615 ingredient Substances 0.000 description 3
- 230000002265 prevention Effects 0.000 description 3
- 229940071089 sarcosinate Drugs 0.000 description 3
- 239000003765 sweetening agent Substances 0.000 description 3
- 239000001490 (3R)-3,7-dimethylocta-1,6-dien-3-ol Substances 0.000 description 2
- KRLBLPBPZSSIGH-CSKARUKUSA-N (6e)-3,7-dimethylnona-1,6-dien-3-ol Chemical compound CC\C(C)=C\CCC(C)(O)C=C KRLBLPBPZSSIGH-CSKARUKUSA-N 0.000 description 2
- CDOSHBSSFJOMGT-JTQLQIEISA-N (R)-linalool Natural products CC(C)=CCC[C@@](C)(O)C=C CDOSHBSSFJOMGT-JTQLQIEISA-N 0.000 description 2
- WUOACPNHFRMFPN-SECBINFHSA-N (S)-(-)-alpha-terpineol Chemical compound CC1=CC[C@@H](C(C)(C)O)CC1 WUOACPNHFRMFPN-SECBINFHSA-N 0.000 description 2
- WEEGYLXZBRQIMU-UHFFFAOYSA-N 1,8-cineole Natural products C1CC2CCC1(C)OC2(C)C WEEGYLXZBRQIMU-UHFFFAOYSA-N 0.000 description 2
- 239000001074 1-methoxy-4-[(E)-prop-1-enyl]benzene Substances 0.000 description 2
- OWEGMIWEEQEYGQ-UHFFFAOYSA-N 100676-05-9 Natural products OC1C(O)C(O)C(CO)OC1OCC1C(O)C(O)C(O)C(OC2C(OC(O)C(O)C2O)CO)O1 OWEGMIWEEQEYGQ-UHFFFAOYSA-N 0.000 description 2
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 description 2
- 108010011485 Aspartame Proteins 0.000 description 2
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical group [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 description 2
- NPBVQXIMTZKSBA-UHFFFAOYSA-N Chavibetol Natural products COC1=CC=C(CC=C)C=C1O NPBVQXIMTZKSBA-UHFFFAOYSA-N 0.000 description 2
- 244000223760 Cinnamomum zeylanicum Species 0.000 description 2
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 description 2
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 description 2
- 208000006558 Dental Calculus Diseases 0.000 description 2
- ULGZDMOVFRHVEP-RWJQBGPGSA-N Erythromycin Chemical compound O([C@@H]1[C@@H](C)C(=O)O[C@@H]([C@@]([C@H](O)[C@@H](C)C(=O)[C@H](C)C[C@@](C)(O)[C@H](O[C@H]2[C@@H]([C@H](C[C@@H](C)O2)N(C)C)O)[C@H]1C)(C)O)CC)[C@H]1C[C@@](C)(OC)[C@@H](O)[C@H](C)O1 ULGZDMOVFRHVEP-RWJQBGPGSA-N 0.000 description 2
- 239000005770 Eugenol Substances 0.000 description 2
- 229920001503 Glucan Polymers 0.000 description 2
- GUBGYTABKSRVRQ-PICCSMPSSA-N Maltose Natural products O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@@H](CO)OC(O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-PICCSMPSSA-N 0.000 description 2
- 244000024873 Mentha crispa Species 0.000 description 2
- 235000014749 Mentha crispa Nutrition 0.000 description 2
- 229920003171 Poly (ethylene oxide) Polymers 0.000 description 2
- UVMRYBDEERADNV-UHFFFAOYSA-N Pseudoeugenol Natural products COC1=CC(C(C)=C)=CC=C1O UVMRYBDEERADNV-UHFFFAOYSA-N 0.000 description 2
- REFJWTPEDVJJIY-UHFFFAOYSA-N Quercetin Chemical compound C=1C(O)=CC(O)=C(C(C=2O)=O)C=1OC=2C1=CC=C(O)C(O)=C1 REFJWTPEDVJJIY-UHFFFAOYSA-N 0.000 description 2
- 244000178231 Rosmarinus officinalis Species 0.000 description 2
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 2
- DBMJMQXJHONAFJ-UHFFFAOYSA-M Sodium laurylsulphate Chemical compound [Na+].CCCCCCCCCCCCOS([O-])(=O)=O DBMJMQXJHONAFJ-UHFFFAOYSA-M 0.000 description 2
- 229920002125 Sokalan® Polymers 0.000 description 2
- 241000194019 Streptococcus mutans Species 0.000 description 2
- 239000005844 Thymol Substances 0.000 description 2
- TVXBFESIOXBWNM-UHFFFAOYSA-N Xylitol Natural products OCCC(O)C(O)C(O)CCO TVXBFESIOXBWNM-UHFFFAOYSA-N 0.000 description 2
- 239000003242 anti bacterial agent Substances 0.000 description 2
- 239000000605 aspartame Substances 0.000 description 2
- IAOZJIPTCAWIRG-QWRGUYRKSA-N aspartame Chemical compound OC(=O)C[C@H](N)C(=O)N[C@H](C(=O)OC)CC1=CC=CC=C1 IAOZJIPTCAWIRG-QWRGUYRKSA-N 0.000 description 2
- 235000010357 aspartame Nutrition 0.000 description 2
- 229960003438 aspartame Drugs 0.000 description 2
- WPYMKLBDIGXBTP-UHFFFAOYSA-N benzoic acid Chemical compound OC(=O)C1=CC=CC=C1 WPYMKLBDIGXBTP-UHFFFAOYSA-N 0.000 description 2
- 229960003237 betaine Drugs 0.000 description 2
- 239000001506 calcium phosphate Substances 0.000 description 2
- OSGAYBCDTDRGGQ-UHFFFAOYSA-L calcium sulfate Chemical compound [Ca+2].[O-]S([O-])(=O)=O OSGAYBCDTDRGGQ-UHFFFAOYSA-L 0.000 description 2
- 239000003093 cationic surfactant Substances 0.000 description 2
- 229960005233 cineole Drugs 0.000 description 2
- 235000017803 cinnamon Nutrition 0.000 description 2
- QMVPMAAFGQKVCJ-UHFFFAOYSA-N citronellol Chemical compound OCCC(C)CCC=C(C)C QMVPMAAFGQKVCJ-UHFFFAOYSA-N 0.000 description 2
- JOZKFWLRHCDGJA-UHFFFAOYSA-N citronellol acetate Chemical compound CC(=O)OCCC(C)CCC=C(C)C JOZKFWLRHCDGJA-UHFFFAOYSA-N 0.000 description 2
- 150000001875 compounds Chemical class 0.000 description 2
- GHVNFZFCNZKVNT-UHFFFAOYSA-N decanoic acid Chemical compound CCCCCCCCCC(O)=O GHVNFZFCNZKVNT-UHFFFAOYSA-N 0.000 description 2
- 201000010099 disease Diseases 0.000 description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
- 238000004821 distillation Methods 0.000 description 2
- LQZZUXJYWNFBMV-UHFFFAOYSA-N dodecan-1-ol Chemical compound CCCCCCCCCCCCO LQZZUXJYWNFBMV-UHFFFAOYSA-N 0.000 description 2
- 239000002552 dosage form Substances 0.000 description 2
- 238000001035 drying Methods 0.000 description 2
- 229960002217 eugenol Drugs 0.000 description 2
- 235000011389 fruit/vegetable juice Nutrition 0.000 description 2
- 235000011187 glycerol Nutrition 0.000 description 2
- LPLVUJXQOOQHMX-UHFFFAOYSA-N glycyrrhetinic acid glycoside Natural products C1CC(C2C(C3(CCC4(C)CCC(C)(CC4C3=CC2=O)C(O)=O)C)(C)CC2)(C)C2C(C)(C)C1OC1OC(C(O)=O)C(O)C(O)C1OC1OC(C(O)=O)C(O)C(O)C1O LPLVUJXQOOQHMX-UHFFFAOYSA-N 0.000 description 2
- 229960004949 glycyrrhizic acid Drugs 0.000 description 2
- UYRUBYNTXSDKQT-UHFFFAOYSA-N glycyrrhizic acid Natural products CC1(C)C(CCC2(C)C1CCC3(C)C2C(=O)C=C4C5CC(C)(CCC5(C)CCC34C)C(=O)O)OC6OC(C(O)C(O)C6OC7OC(O)C(O)C(O)C7C(=O)O)C(=O)O UYRUBYNTXSDKQT-UHFFFAOYSA-N 0.000 description 2
- 235000019410 glycyrrhizin Nutrition 0.000 description 2
- LPLVUJXQOOQHMX-QWBHMCJMSA-N glycyrrhizinic acid Chemical compound O([C@@H]1[C@@H](O)[C@H](O)[C@H](O[C@@H]1O[C@@H]1C([C@H]2[C@]([C@@H]3[C@@]([C@@]4(CC[C@@]5(C)CC[C@@](C)(C[C@H]5C4=CC3=O)C(O)=O)C)(C)CC2)(C)CC1)(C)C)C(O)=O)[C@@H]1O[C@H](C(O)=O)[C@@H](O)[C@H](O)[C@H]1O LPLVUJXQOOQHMX-QWBHMCJMSA-N 0.000 description 2
- 235000001510 limonene Nutrition 0.000 description 2
- 229940087305 limonene Drugs 0.000 description 2
- 229930007744 linalool Natural products 0.000 description 2
- HEBKCHPVOIAQTA-UHFFFAOYSA-N meso ribitol Natural products OCC(O)C(O)C(O)CO HEBKCHPVOIAQTA-UHFFFAOYSA-N 0.000 description 2
- RUVINXPYWBROJD-UHFFFAOYSA-N para-methoxyphenyl Natural products COC1=CC=C(C=CC)C=C1 RUVINXPYWBROJD-UHFFFAOYSA-N 0.000 description 2
- 239000006072 paste Substances 0.000 description 2
- 230000000144 pharmacologic effect Effects 0.000 description 2
- 238000010298 pulverizing process Methods 0.000 description 2
- HELXLJCILKEWJH-NCGAPWICSA-N rebaudioside A Chemical compound O([C@H]1[C@H](O)[C@@H](CO)O[C@H]([C@@H]1O[C@H]1[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O1)O)O[C@]12C(=C)C[C@@]3(C1)CC[C@@H]1[C@@](C)(CCC[C@]1([C@@H]3CC2)C)C(=O)O[C@H]1[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O1)O)[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O HELXLJCILKEWJH-NCGAPWICSA-N 0.000 description 2
- 230000002829 reductive effect Effects 0.000 description 2
- 238000010992 reflux Methods 0.000 description 2
- 235000002020 sage Nutrition 0.000 description 2
- 150000003839 salts Chemical class 0.000 description 2
- 108700004121 sarkosyl Proteins 0.000 description 2
- 239000000377 silicon dioxide Substances 0.000 description 2
- PUZPDOWCWNUUKD-UHFFFAOYSA-M sodium fluoride Chemical compound [F-].[Na+] PUZPDOWCWNUUKD-UHFFFAOYSA-M 0.000 description 2
- KSAVQLQVUXSOCR-UHFFFAOYSA-M sodium lauroyl sarcosinate Chemical compound [Na+].CCCCCCCCCCCC(=O)N(C)CC([O-])=O KSAVQLQVUXSOCR-UHFFFAOYSA-M 0.000 description 2
- 235000019333 sodium laurylsulphate Nutrition 0.000 description 2
- 239000000600 sorbitol Substances 0.000 description 2
- 235000010356 sorbitol Nutrition 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 239000004094 surface-active agent Substances 0.000 description 2
- 229960000790 thymol Drugs 0.000 description 2
- 239000003053 toxin Substances 0.000 description 2
- 231100000765 toxin Toxicity 0.000 description 2
- 108700012359 toxins Proteins 0.000 description 2
- RUVINXPYWBROJD-ONEGZZNKSA-N trans-anethole Chemical compound COC1=CC=C(\C=C\C)C=C1 RUVINXPYWBROJD-ONEGZZNKSA-N 0.000 description 2
- 235000012141 vanillin Nutrition 0.000 description 2
- MWOOGOJBHIARFG-UHFFFAOYSA-N vanillin Chemical compound COC1=CC(C=O)=CC=C1O MWOOGOJBHIARFG-UHFFFAOYSA-N 0.000 description 2
- FGQOOHJZONJGDT-UHFFFAOYSA-N vanillin Natural products COC1=CC(O)=CC(C=O)=C1 FGQOOHJZONJGDT-UHFFFAOYSA-N 0.000 description 2
- 235000013311 vegetables Nutrition 0.000 description 2
- 229940088594 vitamin Drugs 0.000 description 2
- 239000011782 vitamin Substances 0.000 description 2
- 239000000811 xylitol Substances 0.000 description 2
- 235000010447 xylitol Nutrition 0.000 description 2
- HEBKCHPVOIAQTA-SCDXWVJYSA-N xylitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)CO HEBKCHPVOIAQTA-SCDXWVJYSA-N 0.000 description 2
- 229960002675 xylitol Drugs 0.000 description 2
- NOOLISFMXDJSKH-UTLUCORTSA-N (+)-Neomenthol Chemical compound CC(C)[C@@H]1CC[C@@H](C)C[C@@H]1O NOOLISFMXDJSKH-UTLUCORTSA-N 0.000 description 1
- FTLYMKDSHNWQKD-UHFFFAOYSA-N (2,4,5-trichlorophenyl)boronic acid Chemical compound OB(O)C1=CC(Cl)=C(Cl)C=C1Cl FTLYMKDSHNWQKD-UHFFFAOYSA-N 0.000 description 1
- CDVZCUKHEYPEQS-IBVPOFDWSA-N (2r,3s,4r)-2,3,4,5-tetrahydroxypentanal Chemical compound OC[C@@H](O)[C@H](O)[C@@H](O)C=O.OC[C@@H](O)[C@H](O)[C@@H](O)C=O CDVZCUKHEYPEQS-IBVPOFDWSA-N 0.000 description 1
- NOOLISFMXDJSKH-ZDGBYWQASA-N (2s,5r)-5-methyl-2-propan-2-ylcyclohexan-1-ol Chemical compound CC(C)[C@@H]1CC[C@@H](C)CC1O NOOLISFMXDJSKH-ZDGBYWQASA-N 0.000 description 1
- DZWDEGBGKYCSKL-UHFFFAOYSA-N (4-hydroxy-3-methoxyphenyl)methyl acetate Chemical compound COC1=CC(COC(C)=O)=CC=C1O DZWDEGBGKYCSKL-UHFFFAOYSA-N 0.000 description 1
- QYIXCDOBOSTCEI-QCYZZNICSA-N (5alpha)-cholestan-3beta-ol Chemical compound C([C@@H]1CC2)[C@@H](O)CC[C@]1(C)[C@@H]1[C@@H]2[C@@H]2CC[C@H]([C@H](C)CCCC(C)C)[C@@]2(C)CC1 QYIXCDOBOSTCEI-QCYZZNICSA-N 0.000 description 1
- OYHQOLUKZRVURQ-NTGFUMLPSA-N (9Z,12Z)-9,10,12,13-tetratritiooctadeca-9,12-dienoic acid Chemical compound C(CCCCCCC\C(=C(/C\C(=C(/CCCCC)\[3H])\[3H])\[3H])\[3H])(=O)O OYHQOLUKZRVURQ-NTGFUMLPSA-N 0.000 description 1
- WRIDQFICGBMAFQ-UHFFFAOYSA-N (E)-8-Octadecenoic acid Natural products CCCCCCCCCC=CCCCCCCC(O)=O WRIDQFICGBMAFQ-UHFFFAOYSA-N 0.000 description 1
- QMVPMAAFGQKVCJ-SNVBAGLBSA-N (R)-(+)-citronellol Natural products OCC[C@H](C)CCC=C(C)C QMVPMAAFGQKVCJ-SNVBAGLBSA-N 0.000 description 1
- SVIJYLPSHPPVQF-UHFFFAOYSA-N 2-[2,2-diaminoethyl(dodecyl)amino]acetic acid Chemical compound CCCCCCCCCCCCN(CC(N)N)CC(O)=O SVIJYLPSHPPVQF-UHFFFAOYSA-N 0.000 description 1
- GMGBBMQOXFAWRS-UHFFFAOYSA-N 2-[2,2-diaminoethyl(tetradecyl)amino]acetic acid Chemical compound CCCCCCCCCCCCCCN(CC(N)N)CC(O)=O GMGBBMQOXFAWRS-UHFFFAOYSA-N 0.000 description 1
- LQJBNNIYVWPHFW-UHFFFAOYSA-N 20:1omega9c fatty acid Natural products CCCCCCCCCCC=CCCCCCCCC(O)=O LQJBNNIYVWPHFW-UHFFFAOYSA-N 0.000 description 1
- XGRSAFKZAGGXJV-UHFFFAOYSA-N 3-azaniumyl-3-cyclohexylpropanoate Chemical compound OC(=O)CC(N)C1CCCCC1 XGRSAFKZAGGXJV-UHFFFAOYSA-N 0.000 description 1
- SLXKOJJOQWFEFD-UHFFFAOYSA-N 6-aminohexanoic acid Chemical compound NCCCCCC(O)=O SLXKOJJOQWFEFD-UHFFFAOYSA-N 0.000 description 1
- QSBYPNXLFMSGKH-UHFFFAOYSA-N 9-Heptadecensaeure Natural products CCCCCCCC=CCCCCCCCC(O)=O QSBYPNXLFMSGKH-UHFFFAOYSA-N 0.000 description 1
- 239000005711 Benzoic acid Substances 0.000 description 1
- 239000005632 Capric acid (CAS 334-48-5) Substances 0.000 description 1
- 241000208365 Celastraceae Species 0.000 description 1
- JOZKFWLRHCDGJA-LLVKDONJSA-N Citronellyl acetate Natural products CC(=O)OCC[C@H](C)CCC=C(C)C JOZKFWLRHCDGJA-LLVKDONJSA-N 0.000 description 1
- 229920000858 Cyclodextrin Polymers 0.000 description 1
- KVSNMTUIMXZPLU-UHFFFAOYSA-N D:A-friedo-oleanane Natural products CC12CCC3(C)C4CC(C)(C)CCC4(C)CCC3(C)C2CCC2(C)C1CCCC2C KVSNMTUIMXZPLU-UHFFFAOYSA-N 0.000 description 1
- ZAKOWWREFLAJOT-UHFFFAOYSA-N DL-alpha-tocopherylacetate Chemical compound CC(=O)OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C ZAKOWWREFLAJOT-UHFFFAOYSA-N 0.000 description 1
- NOOLISFMXDJSKH-UHFFFAOYSA-N DL-menthol Natural products CC(C)C1CCC(C)CC1O NOOLISFMXDJSKH-UHFFFAOYSA-N 0.000 description 1
- 239000004375 Dextrin Substances 0.000 description 1
- 229920001353 Dextrin Polymers 0.000 description 1
- 235000019739 Dicalciumphosphate Nutrition 0.000 description 1
- 239000004097 EU approved flavor enhancer Substances 0.000 description 1
- 241000196324 Embryophyta Species 0.000 description 1
- 239000004386 Erythritol Substances 0.000 description 1
- UNXHWFMMPAWVPI-UHFFFAOYSA-N Erythritol Natural products OCC(O)C(O)CO UNXHWFMMPAWVPI-UHFFFAOYSA-N 0.000 description 1
- WEEGYLXZBRQIMU-WAAGHKOSSA-N Eucalyptol Chemical compound C1C[C@H]2CC[C@]1(C)OC2(C)C WEEGYLXZBRQIMU-WAAGHKOSSA-N 0.000 description 1
- 239000001512 FEMA 4601 Substances 0.000 description 1
- JUUHNUPNMCGYDT-UHFFFAOYSA-N Friedelin Natural products CC1CC2C(C)(CCC3(C)C4CC(C)(C)CCC4(C)CCC23C)C5CCC(=O)C(C)C15 JUUHNUPNMCGYDT-UHFFFAOYSA-N 0.000 description 1
- 239000005715 Fructose Substances 0.000 description 1
- 229930091371 Fructose Natural products 0.000 description 1
- RFSUNEUAIZKAJO-ARQDHWQXSA-N Fructose Chemical compound OC[C@H]1O[C@](O)(CO)[C@@H](O)[C@@H]1O RFSUNEUAIZKAJO-ARQDHWQXSA-N 0.000 description 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 1
- 239000004378 Glycyrrhizin Substances 0.000 description 1
- 206010061218 Inflammation Diseases 0.000 description 1
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 1
- VTAJIXDZFCRWBR-UHFFFAOYSA-N Licoricesaponin B2 Natural products C1C(C2C(C3(CCC4(C)CCC(C)(CC4C3=CC2)C(O)=O)C)(C)CC2)(C)C2C(C)(C)CC1OC1OC(C(O)=O)C(O)C(O)C1OC1OC(C(O)=O)C(O)C(O)C1O VTAJIXDZFCRWBR-UHFFFAOYSA-N 0.000 description 1
- OSWPMRLSEDHDFF-UHFFFAOYSA-N Methyl salicylate Natural products COC(=O)C1=CC=CC=C1O OSWPMRLSEDHDFF-UHFFFAOYSA-N 0.000 description 1
- 239000005642 Oleic acid Substances 0.000 description 1
- ZQPPMHVWECSIRJ-UHFFFAOYSA-N Oleic acid Natural products CCCCCCCCC=CCCCCCCCC(O)=O ZQPPMHVWECSIRJ-UHFFFAOYSA-N 0.000 description 1
- 208000025157 Oral disease Diseases 0.000 description 1
- 244000131316 Panax pseudoginseng Species 0.000 description 1
- 235000005035 Panax pseudoginseng ssp. pseudoginseng Nutrition 0.000 description 1
- 235000003140 Panax quinquefolius Nutrition 0.000 description 1
- 229920002230 Pectic acid Polymers 0.000 description 1
- 229930182555 Penicillin Natural products 0.000 description 1
- JGSARLDLIJGVTE-MBNYWOFBSA-N Penicillin G Chemical compound N([C@H]1[C@H]2SC([C@@H](N2C1=O)C(O)=O)(C)C)C(=O)CC1=CC=CC=C1 JGSARLDLIJGVTE-MBNYWOFBSA-N 0.000 description 1
- 239000004721 Polyphenylene oxide Substances 0.000 description 1
- 239000004743 Polypropylene Substances 0.000 description 1
- 239000004372 Polyvinyl alcohol Substances 0.000 description 1
- OFOBLEOULBTSOW-UHFFFAOYSA-N Propanedioic acid Natural products OC(=O)CC(O)=O OFOBLEOULBTSOW-UHFFFAOYSA-N 0.000 description 1
- ZVOLCUVKHLEPEV-UHFFFAOYSA-N Quercetagetin Natural products C1=C(O)C(O)=CC=C1C1=C(O)C(=O)C2=C(O)C(O)=C(O)C=C2O1 ZVOLCUVKHLEPEV-UHFFFAOYSA-N 0.000 description 1
- HELXLJCILKEWJH-SEAGSNCFSA-N Rebaudioside A Natural products O=C(O[C@H]1[C@@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1)[C@@]1(C)[C@@H]2[C@](C)([C@H]3[C@@]4(CC(=C)[C@@](O[C@H]5[C@H](O[C@H]6[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O6)[C@@H](O[C@H]6[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O6)[C@H](O)[C@@H](CO)O5)(C4)CC3)CC2)CCC1 HELXLJCILKEWJH-SEAGSNCFSA-N 0.000 description 1
- HWTZYBCRDDUBJY-UHFFFAOYSA-N Rhynchosin Natural products C1=C(O)C(O)=CC=C1C1=C(O)C(=O)C2=CC(O)=C(O)C=C2O1 HWTZYBCRDDUBJY-UHFFFAOYSA-N 0.000 description 1
- 241000134968 Sapindales Species 0.000 description 1
- 244000228451 Stevia rebaudiana Species 0.000 description 1
- UEDUENGHJMELGK-HYDKPPNVSA-N Stevioside Chemical compound O([C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1O[C@]12C(=C)C[C@@]3(C1)CC[C@@H]1[C@@](C)(CCC[C@]1([C@@H]3CC2)C)C(=O)O[C@H]1[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O1)O)[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O UEDUENGHJMELGK-HYDKPPNVSA-N 0.000 description 1
- 229930006000 Sucrose Natural products 0.000 description 1
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 1
- 239000004098 Tetracycline Substances 0.000 description 1
- 208000010641 Tooth disease Diseases 0.000 description 1
- 229920001615 Tragacanth Polymers 0.000 description 1
- XEFQLINVKFYRCS-UHFFFAOYSA-N Triclosan Chemical compound OC1=CC(Cl)=CC=C1OC1=CC=C(Cl)C=C1Cl XEFQLINVKFYRCS-UHFFFAOYSA-N 0.000 description 1
- 229930003448 Vitamin K Natural products 0.000 description 1
- YKTSYUJCYHOUJP-UHFFFAOYSA-N [O--].[Al+3].[Al+3].[O-][Si]([O-])([O-])[O-] Chemical compound [O--].[Al+3].[Al+3].[O-][Si]([O-])([O-])[O-] YKTSYUJCYHOUJP-UHFFFAOYSA-N 0.000 description 1
- 238000002835 absorbance Methods 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 150000008065 acid anhydrides Chemical group 0.000 description 1
- 239000000654 additive Substances 0.000 description 1
- 239000000853 adhesive Substances 0.000 description 1
- 230000001070 adhesive effect Effects 0.000 description 1
- 235000010443 alginic acid Nutrition 0.000 description 1
- 239000000783 alginic acid Substances 0.000 description 1
- 229920000615 alginic acid Polymers 0.000 description 1
- 229960001126 alginic acid Drugs 0.000 description 1
- 150000004781 alginic acids Chemical class 0.000 description 1
- 229910052783 alkali metal Inorganic materials 0.000 description 1
- 150000001340 alkali metals Chemical class 0.000 description 1
- OVKDFILSBMEKLT-UHFFFAOYSA-N alpha-Terpineol Natural products CC(=C)C1(O)CCC(C)=CC1 OVKDFILSBMEKLT-UHFFFAOYSA-N 0.000 description 1
- QYIXCDOBOSTCEI-UHFFFAOYSA-N alpha-cholestanol Natural products C1CC2CC(O)CCC2(C)C2C1C1CCC(C(C)CCCC(C)C)C1(C)CC2 QYIXCDOBOSTCEI-UHFFFAOYSA-N 0.000 description 1
- AWUCVROLDVIAJX-UHFFFAOYSA-N alpha-glycerophosphate Natural products OCC(O)COP(O)(O)=O AWUCVROLDVIAJX-UHFFFAOYSA-N 0.000 description 1
- DTOSIQBPPRVQHS-PDBXOOCHSA-N alpha-linolenic acid Chemical compound CC\C=C/C\C=C/C\C=C/CCCCCCCC(O)=O DTOSIQBPPRVQHS-PDBXOOCHSA-N 0.000 description 1
- 235000020661 alpha-linolenic acid Nutrition 0.000 description 1
- 229940088601 alpha-terpineol Drugs 0.000 description 1
- 229910052782 aluminium Inorganic materials 0.000 description 1
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 description 1
- WNROFYMDJYEPJX-UHFFFAOYSA-K aluminium hydroxide Chemical compound [OH-].[OH-].[OH-].[Al+3] WNROFYMDJYEPJX-UHFFFAOYSA-K 0.000 description 1
- 229960002684 aminocaproic acid Drugs 0.000 description 1
- 230000000202 analgesic effect Effects 0.000 description 1
- 230000000954 anitussive effect Effects 0.000 description 1
- 230000003110 anti-inflammatory effect Effects 0.000 description 1
- 229940088710 antibiotic agent Drugs 0.000 description 1
- 229940124584 antitussives Drugs 0.000 description 1
- 229960005070 ascorbic acid Drugs 0.000 description 1
- 235000010323 ascorbic acid Nutrition 0.000 description 1
- 239000011668 ascorbic acid Substances 0.000 description 1
- 239000000305 astragalus gummifer gum Substances 0.000 description 1
- 239000003899 bactericide agent Substances 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 229960000686 benzalkonium chloride Drugs 0.000 description 1
- 229960001950 benzethonium chloride Drugs 0.000 description 1
- UREZNYTWGJKWBI-UHFFFAOYSA-M benzethonium chloride Chemical compound [Cl-].C1=CC(C(C)(C)CC(C)(C)C)=CC=C1OCCOCC[N+](C)(C)CC1=CC=CC=C1 UREZNYTWGJKWBI-UHFFFAOYSA-M 0.000 description 1
- 235000010233 benzoic acid Nutrition 0.000 description 1
- CADWTSSKOVRVJC-UHFFFAOYSA-N benzyl(dimethyl)azanium;chloride Chemical compound [Cl-].C[NH+](C)CC1=CC=CC=C1 CADWTSSKOVRVJC-UHFFFAOYSA-N 0.000 description 1
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 1
- JGQFVRIQXUFPAH-UHFFFAOYSA-N beta-citronellol Natural products OCCC(C)CCCC(C)=C JGQFVRIQXUFPAH-UHFFFAOYSA-N 0.000 description 1
- GUBGYTABKSRVRQ-QUYVBRFLSA-N beta-maltose Chemical compound OC[C@H]1O[C@H](O[C@H]2[C@H](O)[C@@H](O)[C@H](O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@@H]1O GUBGYTABKSRVRQ-QUYVBRFLSA-N 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 230000000740 bleeding effect Effects 0.000 description 1
- 230000017531 blood circulation Effects 0.000 description 1
- 210000000988 bone and bone Anatomy 0.000 description 1
- 210000004556 brain Anatomy 0.000 description 1
- 229910000019 calcium carbonate Inorganic materials 0.000 description 1
- 229960003563 calcium carbonate Drugs 0.000 description 1
- 235000010216 calcium carbonate Nutrition 0.000 description 1
- JUNWLZAGQLJVLR-UHFFFAOYSA-J calcium diphosphate Chemical group [Ca+2].[Ca+2].[O-]P([O-])(=O)OP([O-])([O-])=O JUNWLZAGQLJVLR-UHFFFAOYSA-J 0.000 description 1
- 229940043256 calcium pyrophosphate Drugs 0.000 description 1
- GFIKIVSYJDVOOZ-UHFFFAOYSA-L calcium;fluoro-dioxido-oxo-$l^{5}-phosphane Chemical compound [Ca+2].[O-]P([O-])(F)=O GFIKIVSYJDVOOZ-UHFFFAOYSA-L 0.000 description 1
- 235000014171 carbonated beverage Nutrition 0.000 description 1
- 235000010418 carrageenan Nutrition 0.000 description 1
- 239000000679 carrageenan Substances 0.000 description 1
- 229920001525 carrageenan Polymers 0.000 description 1
- 229940113118 carrageenan Drugs 0.000 description 1
- 239000004359 castor oil Substances 0.000 description 1
- 235000019438 castor oil Nutrition 0.000 description 1
- 125000002091 cationic group Chemical group 0.000 description 1
- 239000001913 cellulose Substances 0.000 description 1
- 229920002678 cellulose Polymers 0.000 description 1
- 229960001927 cetylpyridinium chloride Drugs 0.000 description 1
- YMKDRGPMQRFJGP-UHFFFAOYSA-M cetylpyridinium chloride Chemical compound [Cl-].CCCCCCCCCCCCCCCC[N+]1=CC=CC=C1 YMKDRGPMQRFJGP-UHFFFAOYSA-M 0.000 description 1
- 235000013351 cheese Nutrition 0.000 description 1
- 235000019219 chocolate Nutrition 0.000 description 1
- 229930007050 cineol Natural products 0.000 description 1
- 235000000484 citronellol Nutrition 0.000 description 1
- 239000000084 colloidal system Substances 0.000 description 1
- 239000003086 colorant Substances 0.000 description 1
- 235000009508 confectionery Nutrition 0.000 description 1
- 238000012790 confirmation Methods 0.000 description 1
- 238000001816 cooling Methods 0.000 description 1
- 229920001577 copolymer Polymers 0.000 description 1
- 238000012136 culture method Methods 0.000 description 1
- 238000012258 culturing Methods 0.000 description 1
- 230000006378 damage Effects 0.000 description 1
- 239000000551 dentifrice Substances 0.000 description 1
- 235000019425 dextrin Nutrition 0.000 description 1
- 235000019821 dicalcium diphosphate Nutrition 0.000 description 1
- NEFBYIFKOOEVPA-UHFFFAOYSA-K dicalcium phosphate Chemical compound [Ca+2].[Ca+2].[O-]P([O-])([O-])=O NEFBYIFKOOEVPA-UHFFFAOYSA-K 0.000 description 1
- 229910000390 dicalcium phosphate Inorganic materials 0.000 description 1
- 229940038472 dicalcium phosphate Drugs 0.000 description 1
- PCHPORCSPXIHLZ-UHFFFAOYSA-N diphenhydramine hydrochloride Chemical compound [Cl-].C=1C=CC=CC=1C(OCC[NH+](C)C)C1=CC=CC=C1 PCHPORCSPXIHLZ-UHFFFAOYSA-N 0.000 description 1
- 150000002016 disaccharides Chemical class 0.000 description 1
- 239000002934 diuretic Substances 0.000 description 1
- 230000001882 diuretic effect Effects 0.000 description 1
- 235000013399 edible fruits Nutrition 0.000 description 1
- 239000003792 electrolyte Substances 0.000 description 1
- 239000003974 emollient agent Substances 0.000 description 1
- HELXLJCILKEWJH-UHFFFAOYSA-N entered according to Sigma 01432 Natural products C1CC2C3(C)CCCC(C)(C(=O)OC4C(C(O)C(O)C(CO)O4)O)C3CCC2(C2)CC(=C)C21OC(C1OC2C(C(O)C(O)C(CO)O2)O)OC(CO)C(O)C1OC1OC(CO)C(O)C(O)C1O HELXLJCILKEWJH-UHFFFAOYSA-N 0.000 description 1
- XCDQFROEGGNAER-PFOIMGGJSA-N epi-Friedelanol Chemical compound C([C@H]1[C@]2(C)CC[C@@]34C)C(C)(C)CC[C@]1(C)CC[C@]2(C)[C@H]4CC[C@@]1(C)[C@H]3CC[C@H](O)[C@@H]1C XCDQFROEGGNAER-PFOIMGGJSA-N 0.000 description 1
- FWTBRZMBHIYQSW-UHFFFAOYSA-N epifriedelanol Natural products CC1C(O)C(O)CC2C1(C)CCC3C2(C)CCC4(C)C5CC(C)(C)CCC5(C)C(O)CC34C FWTBRZMBHIYQSW-UHFFFAOYSA-N 0.000 description 1
- UNXHWFMMPAWVPI-ZXZARUISSA-N erythritol Chemical compound OC[C@H](O)[C@H](O)CO UNXHWFMMPAWVPI-ZXZARUISSA-N 0.000 description 1
- 235000019414 erythritol Nutrition 0.000 description 1
- 229940009714 erythritol Drugs 0.000 description 1
- 229960003276 erythromycin Drugs 0.000 description 1
- 230000001747 exhibiting effect Effects 0.000 description 1
- 239000003172 expectorant agent Substances 0.000 description 1
- 230000003419 expectorant effect Effects 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 210000003746 feather Anatomy 0.000 description 1
- 150000002222 fluorine compounds Chemical class 0.000 description 1
- 239000006260 foam Substances 0.000 description 1
- 238000005187 foaming Methods 0.000 description 1
- 239000004088 foaming agent Substances 0.000 description 1
- 235000019264 food flavour enhancer Nutrition 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- OFMXGFHWLZPCFL-SVRPQWSVSA-N friedelin Chemical compound C([C@H]1[C@]2(C)CC[C@@]34C)C(C)(C)CC[C@]1(C)CC[C@]2(C)[C@H]4CC[C@@]1(C)[C@H]3CCC(=O)[C@@H]1C OFMXGFHWLZPCFL-SVRPQWSVSA-N 0.000 description 1
- MFVJCHSUSSRHRH-UHFFFAOYSA-N friedeline Natural products CC1(C)CCC2(C)CCC3C4(C)CCC5C(C)(C)C(=O)CCC5(C)C4CCC3(C)C2C1 MFVJCHSUSSRHRH-UHFFFAOYSA-N 0.000 description 1
- FBPFZTCFMRRESA-GUCUJZIJSA-N galactitol Chemical compound OC[C@H](O)[C@@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-GUCUJZIJSA-N 0.000 description 1
- 235000008434 ginseng Nutrition 0.000 description 1
- 239000008103 glucose Substances 0.000 description 1
- ZEMPKEQAKRGZGQ-XOQCFJPHSA-N glycerol triricinoleate Natural products CCCCCC[C@@H](O)CC=CCCCCCCCC(=O)OC[C@@H](COC(=O)CCCCCCCC=CC[C@@H](O)CCCCCC)OC(=O)CCCCCCCC=CC[C@H](O)CCCCCC ZEMPKEQAKRGZGQ-XOQCFJPHSA-N 0.000 description 1
- 239000001685 glycyrrhizic acid Substances 0.000 description 1
- 239000001963 growth medium Substances 0.000 description 1
- 229940093915 gynecological organic acid Drugs 0.000 description 1
- BTIJJDXEELBZFS-QDUVMHSLSA-K hemin Chemical compound CC1=C(CCC(O)=O)C(C=C2C(CCC(O)=O)=C(C)\C(N2[Fe](Cl)N23)=C\4)=N\C1=C/C2=C(C)C(C=C)=C3\C=C/1C(C)=C(C=C)C/4=N\1 BTIJJDXEELBZFS-QDUVMHSLSA-K 0.000 description 1
- 229940025294 hemin Drugs 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-M hydroxide Chemical group [OH-] XLYOFNOQVPJJNP-UHFFFAOYSA-M 0.000 description 1
- 230000001939 inductive effect Effects 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 230000004054 inflammatory process Effects 0.000 description 1
- 238000001802 infusion Methods 0.000 description 1
- 230000005764 inhibitory process Effects 0.000 description 1
- 229910052500 inorganic mineral Inorganic materials 0.000 description 1
- 229910052816 inorganic phosphate Inorganic materials 0.000 description 1
- QXJSBBXBKPUZAA-UHFFFAOYSA-N isooleic acid Natural products CCCCCCCC=CCCCCCCCCC(O)=O QXJSBBXBKPUZAA-UHFFFAOYSA-N 0.000 description 1
- MWDZOUNAPSSOEL-UHFFFAOYSA-N kaempferol Natural products OC1=C(C(=O)c2cc(O)cc(O)c2O1)c3ccc(O)cc3 MWDZOUNAPSSOEL-UHFFFAOYSA-N 0.000 description 1
- 239000008101 lactose Substances 0.000 description 1
- 229940094522 laponite Drugs 0.000 description 1
- 230000000670 limiting effect Effects 0.000 description 1
- KQQKGWQCNNTQJW-UHFFFAOYSA-N linolenic acid Natural products CC=CCCC=CCC=CCCCCCCCC(O)=O KQQKGWQCNNTQJW-UHFFFAOYSA-N 0.000 description 1
- 229960004488 linolenic acid Drugs 0.000 description 1
- 238000009630 liquid culture Methods 0.000 description 1
- XCOBTUNSZUJCDH-UHFFFAOYSA-B lithium magnesium sodium silicate Chemical compound [Li+].[Li+].[OH-].[OH-].[OH-].[OH-].[OH-].[OH-].[OH-].[OH-].[OH-].[OH-].[OH-].[OH-].[Na+].[Na+].[Mg+2].[Mg+2].[Mg+2].[Mg+2].[Mg+2].[Mg+2].[Mg+2].[Mg+2].[Mg+2].[Mg+2].[Mg+2].[Mg+2].[Mg+2].[Mg+2].[Mg+2].[Mg+2].O1[Si](O2)([O-])O[Si]3([O-])O[Si]1([O-])O[Si]2([O-])O3.O1[Si](O2)([O-])O[Si]3([O-])O[Si]1([O-])O[Si]2([O-])O3.O1[Si](O2)([O-])O[Si]3([O-])O[Si]1([O-])O[Si]2([O-])O3.O1[Si](O2)([O-])O[Si]3([O-])O[Si]1([O-])O[Si]2([O-])O3.O1[Si](O2)([O-])O[Si]3([O-])O[Si]1([O-])O[Si]2([O-])O3.O1[Si](O2)([O-])O[Si]3([O-])O[Si]1([O-])O[Si]2([O-])O3 XCOBTUNSZUJCDH-UHFFFAOYSA-B 0.000 description 1
- ZLNQQNXFFQJAID-UHFFFAOYSA-L magnesium carbonate Chemical compound [Mg+2].[O-]C([O-])=O ZLNQQNXFFQJAID-UHFFFAOYSA-L 0.000 description 1
- 239000001095 magnesium carbonate Substances 0.000 description 1
- 229910000021 magnesium carbonate Inorganic materials 0.000 description 1
- 239000011976 maleic acid Substances 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 239000002609 medium Substances 0.000 description 1
- DRLFMBDRBRZALE-UHFFFAOYSA-N melatonin Chemical compound COC1=CC=C2NC=C(CCNC(C)=O)C2=C1 DRLFMBDRBRZALE-UHFFFAOYSA-N 0.000 description 1
- 229940041616 menthol Drugs 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- RCYSGAYIEFAJTG-UHFFFAOYSA-N methyl acetate;propanoic acid Chemical compound CCC(O)=O.COC(C)=O RCYSGAYIEFAJTG-UHFFFAOYSA-N 0.000 description 1
- 229960001047 methyl salicylate Drugs 0.000 description 1
- 244000000010 microbial pathogen Species 0.000 description 1
- 239000011707 mineral Substances 0.000 description 1
- 235000010755 mineral Nutrition 0.000 description 1
- 239000011259 mixed solution Substances 0.000 description 1
- 150000002772 monosaccharides Chemical class 0.000 description 1
- 239000000278 mouth detergent Substances 0.000 description 1
- 208000030194 mouth disease Diseases 0.000 description 1
- 239000002736 nonionic surfactant Substances 0.000 description 1
- 231100000956 nontoxicity Toxicity 0.000 description 1
- 235000015097 nutrients Nutrition 0.000 description 1
- ZQPPMHVWECSIRJ-KTKRTIGZSA-N oleic acid Chemical compound CCCCCCCC\C=C/CCCCCCCC(O)=O ZQPPMHVWECSIRJ-KTKRTIGZSA-N 0.000 description 1
- 235000021313 oleic acid Nutrition 0.000 description 1
- 244000039328 opportunistic pathogen Species 0.000 description 1
- 150000007524 organic acids Chemical class 0.000 description 1
- 235000005985 organic acids Nutrition 0.000 description 1
- 230000001717 pathogenic effect Effects 0.000 description 1
- LCLHHZYHLXDRQG-ZNKJPWOQSA-N pectic acid Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)O[C@H](C(O)=O)[C@@H]1OC1[C@H](O)[C@@H](O)[C@@H](OC2[C@@H]([C@@H](O)[C@@H](O)[C@H](O2)C(O)=O)O)[C@@H](C(O)=O)O1 LCLHHZYHLXDRQG-ZNKJPWOQSA-N 0.000 description 1
- 229940049954 penicillin Drugs 0.000 description 1
- KFHHGNBIPJDZPH-UHFFFAOYSA-D pentamagnesium [oxido(phosphonatooxy)phosphoryl] phosphate Chemical compound [Mg+2].[Mg+2].[Mg+2].[Mg+2].[Mg+2].[O-]P([O-])(=O)OP([O-])(=O)OP([O-])([O-])=O.[O-]P([O-])(=O)OP([O-])(=O)OP([O-])([O-])=O KFHHGNBIPJDZPH-UHFFFAOYSA-D 0.000 description 1
- 230000003239 periodontal effect Effects 0.000 description 1
- SHUZOJHMOBOZST-UHFFFAOYSA-N phylloquinone Natural products CC(C)CCCCC(C)CCC(C)CCCC(=CCC1=C(C)C(=O)c2ccccc2C1=O)C SHUZOJHMOBOZST-UHFFFAOYSA-N 0.000 description 1
- 238000005498 polishing Methods 0.000 description 1
- 229920003229 poly(methyl methacrylate) Polymers 0.000 description 1
- 229920001495 poly(sodium acrylate) polymer Polymers 0.000 description 1
- 239000004584 polyacrylic acid Substances 0.000 description 1
- 229920000570 polyether Polymers 0.000 description 1
- 239000010318 polygalacturonic acid Substances 0.000 description 1
- 239000004926 polymethyl methacrylate Substances 0.000 description 1
- 229920005862 polyol Polymers 0.000 description 1
- 150000003077 polyols Chemical class 0.000 description 1
- 229920000056 polyoxyethylene ether Polymers 0.000 description 1
- 229940051841 polyoxyethylene ether Drugs 0.000 description 1
- 229920002503 polyoxyethylene-polyoxypropylene Polymers 0.000 description 1
- 229920001155 polypropylene Polymers 0.000 description 1
- 229920001451 polypropylene glycol Polymers 0.000 description 1
- 229920001282 polysaccharide Polymers 0.000 description 1
- 239000005017 polysaccharide Substances 0.000 description 1
- 150000004804 polysaccharides Chemical class 0.000 description 1
- 229920002451 polyvinyl alcohol Polymers 0.000 description 1
- 239000001267 polyvinylpyrrolidone Substances 0.000 description 1
- 229920000036 polyvinylpyrrolidone Polymers 0.000 description 1
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 description 1
- 239000003755 preservative agent Substances 0.000 description 1
- 230000001681 protective effect Effects 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- ZUFQODAHGAHPFQ-UHFFFAOYSA-N pyridoxine hydrochloride Chemical compound Cl.CC1=NC=C(CO)C(CO)=C1O ZUFQODAHGAHPFQ-UHFFFAOYSA-N 0.000 description 1
- 239000011764 pyridoxine hydrochloride Substances 0.000 description 1
- 229960004172 pyridoxine hydrochloride Drugs 0.000 description 1
- 235000019171 pyridoxine hydrochloride Nutrition 0.000 description 1
- 229960001285 quercetin Drugs 0.000 description 1
- 235000005875 quercetin Nutrition 0.000 description 1
- 235000019203 rebaudioside A Nutrition 0.000 description 1
- 229940081974 saccharin Drugs 0.000 description 1
- 235000019204 saccharin Nutrition 0.000 description 1
- CVHZOJJKTDOEJC-UHFFFAOYSA-N saccharin Chemical compound C1=CC=C2C(=O)NS(=O)(=O)C2=C1 CVHZOJJKTDOEJC-UHFFFAOYSA-N 0.000 description 1
- 239000000901 saccharin and its Na,K and Ca salt Substances 0.000 description 1
- 229940085605 saccharin sodium Drugs 0.000 description 1
- 150000004671 saturated fatty acids Chemical class 0.000 description 1
- HFHDHCJBZVLPGP-UHFFFAOYSA-N schardinger α-dextrin Chemical compound O1C(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(O)C2O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC2C(O)C(O)C1OC2CO HFHDHCJBZVLPGP-UHFFFAOYSA-N 0.000 description 1
- AWUCVROLDVIAJX-GSVOUGTGSA-N sn-glycerol 3-phosphate Chemical compound OC[C@@H](O)COP(O)(O)=O AWUCVROLDVIAJX-GSVOUGTGSA-N 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- 239000011775 sodium fluoride Substances 0.000 description 1
- 235000013024 sodium fluoride Nutrition 0.000 description 1
- SUKJFIGYRHOWBL-UHFFFAOYSA-N sodium hypochlorite Chemical compound [Na+].Cl[O-] SUKJFIGYRHOWBL-UHFFFAOYSA-N 0.000 description 1
- 229940045885 sodium lauroyl sarcosinate Drugs 0.000 description 1
- 229960004711 sodium monofluorophosphate Drugs 0.000 description 1
- NNMHYFLPFNGQFZ-UHFFFAOYSA-M sodium polyacrylate Chemical compound [Na+].[O-]C(=O)C=C NNMHYFLPFNGQFZ-UHFFFAOYSA-M 0.000 description 1
- 229960000776 sodium tetradecyl sulfate Drugs 0.000 description 1
- KHCOJQDJOCNUGV-UHFFFAOYSA-M sodium;2-[methyl(tetradecanoyl)amino]acetate Chemical compound [Na+].CCCCCCCCCCCCCC(=O)N(C)CC([O-])=O KHCOJQDJOCNUGV-UHFFFAOYSA-M 0.000 description 1
- UPUIQOIQVMNQAP-UHFFFAOYSA-M sodium;tetradecyl sulfate Chemical compound [Na+].CCCCCCCCCCCCCCOS([O-])(=O)=O UPUIQOIQVMNQAP-UHFFFAOYSA-M 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 229960002920 sorbitol Drugs 0.000 description 1
- 239000007921 spray Substances 0.000 description 1
- 239000003381 stabilizer Substances 0.000 description 1
- ANOBYBYXJXCGBS-UHFFFAOYSA-L stannous fluoride Chemical compound F[Sn]F ANOBYBYXJXCGBS-UHFFFAOYSA-L 0.000 description 1
- 229960002799 stannous fluoride Drugs 0.000 description 1
- 230000003068 static effect Effects 0.000 description 1
- 229940013618 stevioside Drugs 0.000 description 1
- OHHNJQXIOPOJSC-UHFFFAOYSA-N stevioside Natural products CC1(CCCC2(C)C3(C)CCC4(CC3(CCC12C)CC4=C)OC5OC(CO)C(O)C(O)C5OC6OC(CO)C(O)C(O)C6O)C(=O)OC7OC(CO)C(O)C(O)C7O OHHNJQXIOPOJSC-UHFFFAOYSA-N 0.000 description 1
- 235000019202 steviosides Nutrition 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 239000011550 stock solution Substances 0.000 description 1
- 239000005720 sucrose Substances 0.000 description 1
- 150000005846 sugar alcohols Chemical class 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- 230000002195 synergetic effect Effects 0.000 description 1
- 229920001059 synthetic polymer Polymers 0.000 description 1
- 229920003002 synthetic resin Polymers 0.000 description 1
- 239000000057 synthetic resin Substances 0.000 description 1
- 238000010998 test method Methods 0.000 description 1
- 229960002180 tetracycline Drugs 0.000 description 1
- 229930101283 tetracycline Natural products 0.000 description 1
- 235000019364 tetracycline Nutrition 0.000 description 1
- 150000003522 tetracyclines Chemical class 0.000 description 1
- 230000008719 thickening Effects 0.000 description 1
- 239000002562 thickening agent Substances 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- GYDJEQRTZSCIOI-LJGSYFOKSA-N tranexamic acid Chemical compound NC[C@H]1CC[C@H](C(O)=O)CC1 GYDJEQRTZSCIOI-LJGSYFOKSA-N 0.000 description 1
- 229960000401 tranexamic acid Drugs 0.000 description 1
- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 description 1
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical group [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 1
- 229940078499 tricalcium phosphate Drugs 0.000 description 1
- 229910000391 tricalcium phosphate Inorganic materials 0.000 description 1
- 235000019731 tricalcium phosphate Nutrition 0.000 description 1
- 229960003500 triclosan Drugs 0.000 description 1
- 235000015112 vegetable and seed oil Nutrition 0.000 description 1
- 235000013343 vitamin Nutrition 0.000 description 1
- 229930003231 vitamin Natural products 0.000 description 1
- 235000019168 vitamin K Nutrition 0.000 description 1
- 239000011712 vitamin K Substances 0.000 description 1
- 150000003721 vitamin K derivatives Chemical class 0.000 description 1
- 229940046010 vitamin k Drugs 0.000 description 1
- 239000000230 xanthan gum Substances 0.000 description 1
- 229920001285 xanthan gum Polymers 0.000 description 1
- 235000010493 xanthan gum Nutrition 0.000 description 1
- 229940082509 xanthan gum Drugs 0.000 description 1
- UHVMMEOXYDMDKI-JKYCWFKZSA-L zinc;1-(5-cyanopyridin-2-yl)-3-[(1s,2s)-2-(6-fluoro-2-hydroxy-3-propanoylphenyl)cyclopropyl]urea;diacetate Chemical compound [Zn+2].CC([O-])=O.CC([O-])=O.CCC(=O)C1=CC=C(F)C([C@H]2[C@H](C2)NC(=O)NC=2N=CC(=CC=2)C#N)=C1O UHVMMEOXYDMDKI-JKYCWFKZSA-L 0.000 description 1
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/37—Celastraceae (Staff-tree or Bittersweet family), e.g. tripterygium or spindletree
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/60—Moraceae (Mulberry family), e.g. breadfruit or fig
- A61K36/605—Morus (mulberry)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Botany (AREA)
- Mycology (AREA)
- Epidemiology (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Medical Informatics (AREA)
- Alternative & Traditional Medicine (AREA)
- Birds (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Cosmetics (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
本发明涉及一种含有作为活性成分的桑白皮提取物与卫矛提取物的牙周病预防及治疗用口腔组合物。更具体地说，本发明涉及一种包含具有卓越的牙周炎预防、改善及治疗效果的作为活性成分的桑白皮提取物与卫矛提取物的口腔组合物。凭借本发明，提供了具有卓越的牙周炎预防、改善及治疗效果的口腔组合物或健康功能食品。
Description
技术领域
本发明涉及一种含有作为活性成分的桑白皮提取物与卫矛提取物的牙周病预防及治疗用口腔组合物，更具体地说，本发明涉及一种包含具有卓越的牙周炎预防、改善及治疗效果的作为活性成分的桑白皮提取物与卫矛提取物的口腔组合物。
背景技术
人的口腔内栖息着各种微生物，引起口腔疾病的口腔微生物大部分栖息在形成于牙齿与牙龈之间的细菌膜的菌斑上。
上述口腔微生物在菌斑生成毒素而这些微生物所生产的毒素则侵入牙周组织内引起牙龈的炎症、牙槽骨的破坏及感染而成为牙周病，这些细菌生成酸时则成为蛀齿原因。
如前所述，分布在口腔内的微生物能够引起臼齿及牙周病之类的疾病，这些微生物中的一部分还可以作为条件致病菌而导致各种疾病。
常驻于口腔内并且引起龋齿与牙周炎的病原性微生物有很多种，其中，变形链球菌(Streptococcus mutans)与牙龈卟啉单胞菌(Porphyromonas gingivalis)被视为引起牙周病的主病原体。
牙周炎的发病原因复杂而且其症状也呈多样化。其中，牙周炎的主要发生原因之一为口腔内微生物，这些微生物首先利用糖之类的物质生成不溶性葡聚糖，这些不溶性葡聚糖则和各种菌体一切附接在牙齿表面而形成牙石。该牙石则引起龋齿及牙周炎。
因此，预防牙周炎的最有效方法是使用能够抑制这些微生物的活性并且改善发生了炎症的牙龈血流的物质。亦即，预防牙周炎时虽然适当维持口腔内部清洁非常重要，但以预防治疗为目的混合了各种药剂的口腔用组合物也受到了瞩目。
尤其是，以预防及治疗牙周炎为目的而使用的药剂中青霉素、红霉素、四环素之类的抗生素虽然能够有效杀菌并抑制其生育，但是存在着诱使耐性菌出现之类的副作用。而且，洗必太(chlorhexidine)之类的抗菌剂虽然能够妨碍龋齿的形成，但是其毒性较强。
近来，人们为了解决前述问题而正在努力开发出除了现有口腔用清洗作用以外还具备优异药理作用及稳定性的口腔用组合物。
与此相关的先前技术可以举例大韩民国公开专利第10-2012-0022423号“含有作为活性成分的海燕窝提取物的腔卫生增进用组合物”和大韩民国公开专利第 10-2008-0113504号“含有作为活性成分的人参果实提取物的口腔细菌抑制用组合物”。
桑白皮是桑树(Morus alba L.)或同属植物的根皮，其在很久以前就作为消炎性利尿剂、缓和剂及镇咳祛痰剂应用于中医药剂。
近来，这些桑白皮所含各种成分逐渐被人们发现并且探明了其药理效果，尤其是，其降血压、降血糖及镇痛作用被广泛认知。
卫矛(winged spindle)是无患子目卫矛科的落叶灌木并且分布在韩国、日本、库页岛、中国地区。其嫩叶作为山菜食用而其树枝上的翼则称为归剪羽。叶子含有表木栓醇(epifriedelanol)、木栓酮(friedelin)、槲皮素(quercetin)、卫矛醇(dulcitol)。其种子油则含有饱和脂肪酸(20％)、油酸、亚油酸、亚麻酸、羊蜡酸及安息香酸等。在中医药上用于止血、驱淤血及生理痛。
为此，本发明人为了开发出对牙周炎致病菌具有卓越抗菌效果的药物而使用具备前述效能的桑白皮与卫矛并且确认其效能而完成了本发明。
解决的技术课题
本发明的目的是提供一种含有作为活性成分的桑白皮提取物与卫矛提取物的牙周病预防及治疗用口腔组合物。
本发明需要解决的技术课题不限于前述课题，本领域所属领域中具备通常知识者可以在下面的记载中明确地了解到前面没有提到的其它课题。
解决课题的技术方案
为了达到上述目的，本发明的牙周病预防及治疗用口腔组合物或牙周病预防及改善用健康功能食品的特征在于，含有作为活性成分的桑白皮提取物与卫矛提取物，并且呈现出对牙周炎病原菌的生长抑制活性。
上述牙周炎病原菌是牙龈卟啉单胞菌(Porphyromonas gingivalis)。
上述桑白皮提取物与卫矛提取物以1:1重量比组成。
上述桑白皮提取物或卫矛提取物是以乙醇(Ethanol)提取的。
上述口腔组合物具有选自牙膏类、口香糖、口腔清净剂、口腔清洗剂及口腔喷雾剂的一个以上的剂型。
上述健康功能食品具有选自粉末、颗粒、片剂、胶囊或饮料的一个以上的剂型。
有益效果
凭借本发明，能够提供一种含有作为活性成分的桑白皮提取物与卫矛提取物，具有卓越的牙周炎预防、改善及治疗效果的口腔组合物或健康功能食品。凭此，相比于现有的一般牙膏，本发明能够提高口腔用药效成分的稳定性并且发挥出预防及治疗牙周炎的效果。
附图说明
图1是示出桑白皮提取物的抗菌活性的曲线图。
图2是示出卫矛提取物的抗菌活性的曲线图。
图3是示出由桑白皮提取物(5ppm)+卫矛提取物(5ppm)构成的混合提取物(10ppm)的抗菌活性的曲线图。
图4是示出桑由白皮提取物(25ppm)+卫矛提取物(25ppm)构成的混合提取物(50ppm)的抗菌活性的曲线图。
具体实施方式
下面将详细说明本发明，下面将省略可能会非必要地混淆本发明主旨的公知结构或功能的详细说明。
本发明提供一种含有作为活性成分的桑白皮提取物与卫矛提取物的牙周病预防及治疗用口腔组合物。
此时，关于上述桑白皮提取物或卫矛提取物的提取，先让桑白皮或卫矛各自干燥再以各重量(g)的5～15倍溶剂提取，优选地，可溶于选自水、C1到C4低碳醇或其混合溶剂的提取物，优选地，利用乙醇在10到50℃下(在20到30℃下更佳)于1到150 小时期间(在3到36小时期间更佳)反复提取1到10次(反复提取3到5次更佳)后得到提取物。
把如前所述地制备的上述桑白皮提取物与卫矛提取物各自作为活性成分使用时，在提取物上桑白皮提取物需要以高浓度包含才能对牙周炎病原菌呈现出抗菌活性，卫矛提取物则在100ppm浓度下也没有呈现出抗菌活性。为此，为了制造出即使在低浓度提取物也能呈现出本发明所追求的针对牙周炎病原菌的抗菌活性地制造出可产品化的组合物，把上述桑白皮提取物与上述卫矛提取物混合使用较佳，相比于现有的一般牙膏，本发明不仅能够提高口腔用药效成分的稳定性，还能发挥出牙周炎疾病的预防及治疗效果。
此时，为了得到本发明所追求的对于牙周炎病原菌的最佳生长抑制活性，需要把上述桑白皮提取物与上述卫矛提取物以1:1重量比混合后作为牙周炎预防及治疗用口腔组合物的活性成分使用较佳，本发明尤其对牙周炎病原菌中的牙龈卟啉单胞菌(Porphyromonas gingivalis)呈现出抗菌活性。
如前所述，含有本发明的提取物的口腔组合物可以制成牙膏类、口香糖、口腔清净剂、口腔清洗剂及口腔喷雾剂之类的剂型后使用，但并不限定于此。
本发明的牙膏类包含选自研磨剂、黏结剂、保湿剂、活性成分、发泡剂、甜味料、调味剂的组合物。
关于研磨剂，可以把氢氧化铝、二氧化硅、硅酸铝、磷酸二钙、第二氢氧化物及酸酐、磷酸三钙、碳酸钙、焦磷酸钙、不溶性偏磷酸鈉、磷酸三镁、碳酸镁、硫酸钙、聚甲基丙烯酸甲酯、其它合成树脂等的1种或2种以上以整体组合物的约20-90％的量配合后使用(如果是膏状牙膏，则为20-60％)。
关于黏结剂，可以把角菜胶、各种增粘用纤维素衍生物、黄原胶、龙须胶(Tragacanth gum)之类的胶类、聚乙烯醇、聚丙烯酸钠、聚丙烯酸/马来酸共聚物、羧乙烯基聚合物之类的合成高分子衍生物等有机黏结剂和二氧化硅、锂藻土之类的无机黏结剂的1种或2种以上以整体组合物的约0.3-5％的量配合后使用。
关于牙膏类，在膏态与液态口腔用组合物方面可以在制造时把山梨醇、甘油、乙二醇、丙二醇、聚醚多元醇、聚丙二醇等的1种或2种以上作为保湿剂以整体组合物的约10-70％的量配合后使用。
另一方面，关于含有本发明的提取物的口腔组合物，可以把薄荷醇(Mentol)、茴香脑(Anetol)、丁香油酚(Eugenol)、柠檬油精(Limonene)、罗勒烯(Ocimene)、n-十二醇(n-Dodecy Alcohol)、香茅醇(Citronenol)、α-松油醇(a-Terpineol)、甲基水杨酸辛酯(Methyl salycilate)、乙酸甲酯(Methyl Acetate)、乙酸香草酯(Citronelyl Acetate)、桉油酚(Cineol)、芳樟醇(Linalool)、乙基芳樟醇(Ethyl Linalool)、香草醛(Vanillin)、麝香草酚(Thymol)、荷兰薄荷(Speamint)油、鼠尾草(Sage)油、迷迭香(Rosemary)油、桂皮(Cinamon)油之类的香料以单独或组合方式以整体组合物的0.1-10％，优选地，以 0.5-5％的量配合后使用。
而且，把糖精钠、甜菊苷、阿斯巴甜、D-木糖(D-Xylose)之类的甜味剂等以整体组合物的0-1％，优选地，以0.01-0.5％的量配合后使用。
而且，关于本发明的口腔组合物，可以把二氯苯氧氯酚、双氯苯双胍己烷、苄索氯铵、苯扎氯铵、氯化十六烷吡啶之类的阳离子性杀菌剂；单氟磷酸钠与单氟磷酸钙之类的碱金属单氟磷酸鹽；氟化钠、氟化亚锡之类的氟化物；氨甲环酸、ε-氨基已酸、铝克洛沙、二氢胆甾醇、甘草酸类、甘油磷酸、氯化钠、水溶性无机磷酸化合物、抗坏血酸(纳)、醋酸dl-a-生育酚、木糖醇、盐酸吡哆辛、聚乙烯吡咯烷酮之类的各种效能成分的1种或2种以上加以选择并配合后使用。
而且，在本发明的口腔组合物中作为泡沫成分使用的表面活性剂方面，可以使用阴离子表面活性剂、非离子表面活性剂及/或阳离子表面活性剂。在此，阴离子表面活性剂可以使用十二烷基硫酸钠、十四烷基硫酸钠之类的硫酸烷基钠；月桂酰肌氨酸钠(SodiumN-Lauroyl sarcosinate)、N-十四烷基肌氨酸钠(Sodium N-miristyl sarcosinate) 之类的N-酰基肌氨酸钠(Sodium N-acyl sarcosinate)等，非离子表面活性剂可以使用糖脂肪酸酯、麦芽糖脂肪酸酯、乳糖脂肪酸酯等源于糖的脂肪酸酯；聚氧乙烯氢化蓖麻油、高碳醇聚氧乙烯醚,聚氧乙烯聚氧丙烯共聚物、聚氧乙烯聚丙烯脂肪酸酯等。阳离子表面活性剂可以使用N-十二烷基二氨基乙基甘氨酸(N-LAURYL DIAMINOETHYLGLYCINE),N-十四烷基二氨基乙基甘氨酸之类的N-烷基二氨基乙基甘氨酸、N-烷基-N-羧甲基铵甜菜碱(N-ALKYLCARBOXYMETHYL AMMONIUM BETAINE)、N-烷基-1-羟乙基咪唑啉甜菜碱钠等。此时，泡沫成分主要使用阴离子表面活性剂，其中具有代表性者以十二烷基硫酸钠之类的烷基硫酸钠最广泛地使用。而且，这些表面活性剂可以单独使用1种或者把2种以上混合后使用，配合量通常以整体组合物的0.01-0.5％，更优选地，以0.05-0.3％使用。
而且，本发明还揭示了含有作为活性成分的上述提取物的牙周炎预防及改善用健康功能食品。
含有本发明的提取物的健康功能食品可以多样化地应用于预防及改善牙周炎的药剂、食品及饮料等处。可添加本发明的提取物的食品可以举例各种食品类、饮料、口香糖、茶维生素复合剂、健康辅助食品类等，能以粉末、颗粒、片剂、胶囊或饮料形态使用。
本发明的提取物本身几乎没有毒性及副作用，因此即使为了预防而长时间服用也能够放心使用。
为此，本发明的上述提取物可以为了预防及改善牙周炎而添加到食品或饮料。此时，关于食品或饮料中的上述提取物的量，本发明的健康食品组合物通常可以添加整体食品重量的0.01到15重量％，健康饮料组合物则能以 100mL 为 基准添加0.02到10g，优选地，能以0.3到1g的比率添加。
本发明的健康饮料组合物作为必要成分必须以所设定的比率含有上述提取物或化合物，除此之外，本发明对液体成分没有特别限制，和一般饮料一样地能把各种调味剂或天然碳水化合物等作为辅助性成分包含在内。前述天然碳水化合物可以举例单糖、诸如葡萄糖、果糖之类的二糖；诸如麦芽糖、蔗糖之类的多醣；诸如糊精、环糊精之类的一把糖及木糖醇、山梨糖醇、赤藓醇之类的糖醇。上述成分之外的调味剂可以使用天然调味剂(甜味蛋白、甜叶菊提取物(例如莱苞迪甙A、甘草皂苷等)及合成调味剂(糖精、阿斯巴甜等)。本发明的组合物 100mL 中 上述天然碳水化合物的比率通常是大约1到20g，优选地，大约5到12g。
除此之外，本发明的组合物还可以包含各种营养剂、维生素、矿物(电解质)、合成风味剂及天然风味剂之类的风味剂、着色剂及增味剂(乳酪、巧克力等)、果胶酸及其盐、藻酸及其盐、有机酸、保护性胶体增粘剂、pH调节剂、稳定剂、防腐剂、甘油、乙醇、碳酸饮料所用碳酸化剂等。除此之外，本发明的健康功能食品可以包含用来制作天然果汁、果汁饮料及蔬菜饮料的果肉。该成分可以独立使用或组合后使用。该添加剂的比率不是很重要，但通常以本发明的组合物100重量份为基准选择0到约20重量份。
下面将结合实施例及实验例进一步说明本发明，但这些实施例及实验例的目的仅仅在于说明本发明，其并不能限制本发明的请求范围。
<实施例1>制备由桑白皮提取物+卫矛提取物构成的混合提取物
甲.制备桑白皮提取物
利用精制水清洗桑白皮后，在常温下自然干燥了7天。
在上述干燥处理后以粉碎机予以粉末化，然后把该桑白皮粉末1kg放入70％乙醇10L 并 且在常温下回流提取3小时，反复进行3次后制成了提取物。
过滤上述提取物并且只回收余液，然后减压蒸馏得到液态桑白皮提取物(受领浓度:10000ppm)。
此时，利用灭菌蒸馏水以10倍为单位依次稀释上述制成的桑白皮提取物后制成了各个浓度(0.1、1、10、100、1000、10000ppm)。
乙.制备卫矛提取物
利用精制水清洗卫矛树枝后，在常温下自然干燥了7天。
在上述干燥处理后以粉碎机予以粉末化，然后把该卫矛粉末1kg放入70％乙醇10L 并 且在常温下回流提取3小时，反复进行3次后制成了提取物。
过滤上述提取物并且只回收余液，然后减压蒸馏得到液态卫矛提取物(受领浓度:10000ppm)。
此时，利用灭菌蒸馏水以10倍为单位依次稀释上述制成的卫矛提取物后制成了各个浓度(0.1、1、10、100、1000、10000ppm)。
丙.制备混合提取物
按照各相同浓度备妥上述步骤甲中制成的桑白皮提取物与上述步骤乙中制成的卫矛提取物后，制成了以1:1重量比混合的混合提取物。
<实验例1>确认抗菌活性
为了确认桑白皮提取物与卫矛提取物及它们的混合提取物对牙周炎菌的抗菌活性，进行了MIC(mininal inhibitory concentration)测试。
1.试验对象菌株
所用的菌株是由ATCC美国模式培养物集存库(American type CultureCollection, ATCC BAA-1703TM)分配的作为牙周炎病原菌的牙龈卟啉单胞菌菌株。
2.试验方法
1)菌株培养条件
把上述获得分配的、作为牙周炎病原菌的牙龈卟啉单胞菌(Porphyromonasgingivalis)菌株接种到包含5ug/ml hemin与1ug/ml vitamin K的Brain heart infusionbroth 培养基后，在37℃进行了静止培养。
2)提取物的处理
①让最终混合液成为 1mL 地 把灭菌的液体培养基 0.9mL 、基 于各浓度的提取物 0.1mL( 10％，V/V)、 107cfu/mL 浓 度的细菌培养液 1m L 混 合到试验管后制成了混合液。
②关于提取物，对利用原液与灭菌蒸馏水以10倍为单位依次稀释的稀释液进行了处理。
③桑白皮提取物与卫矛提取物的混合处理组则把各提取物以 0.05mL 放 入，不处理提取物时则处理 0.1mL 的 灭菌蒸馏水。
3)培养方法
在37℃下培养试验管30小时，该试验管则装入了包含细菌培养液、提取物、灭菌后的液体培养基的上述①的混合液。
关于抗菌活性的判定，每培养3小时就取出各处理组的混合液 0.1mL 后 利用96well palte在600nm测量了细菌增殖所导致的吸光度变化。
2.实验结果
1)桑白皮提取物的抗菌活性
图1以牙龈卟啉单胞菌(Porphyromonas gingivalis)菌株为对象对桑白皮提取物的抗菌活性进行了试验，在低浓度的10ppm几乎没有抗菌活性，在25ppm下也只是呈现出较弱的抗菌活性。
2)卫矛提取物的抗菌活性
图2以牙龈卟啉单胞菌(Porphyromonas gingivalis)菌株为对象对卫矛提取物的抗菌活性进行了试验，在低浓度的10ppm、25ppm、50ppm下几乎没有抗菌活性。
3)由桑白皮提取物+卫矛提取物组成的混合提取物的抗菌活性
图3及图4以牙龈卟啉单胞菌(Porphyromonas gingivalis)菌株为对象对桑白皮提取物+卫矛提取物所构成的混合提取物的抗菌活性进行了试验，对混合提取物以 10ppm(图3)和对混合提取物以50ppm(图4)处理时检查了抗菌活性。
如图3所示，单独处理低浓度的卫矛提取物5ppm时(-■-)几乎没有呈现出活性，单独处理桑白皮提取物5ppm时(-▲-)也几乎没有呈现出活性。而且，作为本发明的活性成分的1:1混合提取液10ppm(桑白皮提取物与卫矛提取物各5ppm，实施例1)也几乎没有呈现出活性(-◆-)。
如图4所示，单独处理卫矛提取物25ppm时(-■-)几乎没有呈现出活性，单独处理桑白皮提取物25ppm时(-▲-)虽然微微地呈现出抗菌活性，但无法达到本发明所追求的抗菌活性，与此相反，作为本发明的活性成分的1:1混合提取液50ppm(桑白皮提取物与卫矛提取物各25ppm，实施例1)则对作为牙周炎病原菌的牙龈卟啉单胞菌 (Porphyromonasgingivalis)呈现出强大的抑制活性，相比于单独处理的提取物，作为本发明的活性成分的1:1混合提取液(桑白皮提取物与卫矛提取物各25ppm，实施例1) 被判定为对抗菌活性具备了相乘效应(-◆-)。
因此，利用根据本发明制备的牙周炎预防及治疗用组合物时能够对引起牙周炎的菌株发挥出优异的抗菌活性而能够发挥出预防及治疗牙周炎的效果，凭此，其可以作为健康食品、医药品之类的材料使用而得以提高其附加价值。
<制剂例1:牙膏的制备>
以70到75℃的温度把属于下述表1的a的成分投入制造单元后搅拌20分钟让粉体完全溶解，然后冷却到常温。
接着是保湿剂、甜味料及有益成分的溶解工序，把含有上述实施例1所制载体的属于b的成分以25到30℃投入制造单元后搅拌混合15分钟地予以溶解。
着是粉体及粘性剂混合工序，把属于c的成分在25到35℃混合后按阶段投入。下一个工序是起泡剂混合及第一阶段除沫工序，添加属于d的成分并且在25到35℃下历时40分钟的工序期间完成了第一阶段除沫。最后一个工序是香混合工序，添加属于e 的成分并且在25到35℃下进行第二阶段除沫后制成牙膏。
其组合物则遵守下列表1的内容。
[表1]
前文以优选实施例为主说明了前述本发明，本发明所属领域中具有通常知识者可以在本发明的本质性技术范围内实现不同于上述发明内容的其它形态的实施例。在此，本发明的本质性技术范围呈现在权利要求书中，与其出于同等范围内的一切差异均应阐释为属于本发明。
Claims (4)
1.一种组合物在制备牙周病预防及治疗用口腔药物中的用途，其特征在于，
以1:1重量比含有作为活性成分的桑白皮的70％(v/v)乙醇水溶液提取物与卫矛的70％(v/v)乙醇水溶液提取物，上述桑白皮的70％(v/v)乙醇水溶液提取物与卫矛的70％(v/v)乙醇水溶液提取物的浓度分别为25ppm以上，
并且，该牙周病预防及治疗用口腔药物呈现出对牙周炎致病菌的生长抑制活性，其中，该牙周炎致病菌是牙龈卟啉单胞菌(Porphyromonas gingivalis)。
2.根据权利要求1所述的用途，其特征在于，
上述口腔药物的剂型为牙膏、口香糖、口腔清净剂、口腔清洗剂或口腔喷雾剂。
3.一种组合物在制备牙周病改善用健康功能食品中的用途，其特征在于，
以1:1重量比含有作为活性成分的桑白皮的70％(v/v)乙醇水溶液提取物与卫矛的70％(v/v)乙醇水溶液提取物，上述桑白皮的70％(v/v)乙醇水溶液提取物与卫矛的70％(v/v)乙醇水溶液提取物的浓度分别为25ppm以上，
并且，该牙周病改善用健康功能食品呈现出对牙周炎病原菌的生长抑制活性，其中，该牙周炎病原菌是牙龈卟啉单胞菌(Porphyromonas gingivalis)。
4.根据权利要求3所述的用途，其特征在于，
上述健康功能食品的剂型为粉末、颗粒、片剂、胶囊或饮料。
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| KR1020150096890A KR101641213B1 (ko) | 2015-07-08 | 2015-07-08 | 상백피추출물과 화살나무추출물을 유효성분으로 포함하는 치주염 예방 및 치료용 구강조성물 |
| KR10-2015-0096890 | 2015-07-08 | ||
| PCT/KR2016/006266 WO2017007140A1 (ko) | 2015-07-08 | 2016-06-13 | 상백피추출물과 화살나무추출물을 유효성분으로 포함하는 치주염 예방 및 치료용 구강조성물 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN106535911A CN106535911A (zh) | 2017-03-22 |
| CN106535911B true CN106535911B (zh) | 2020-05-05 |
Family
ID=56680280
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201680000808.7A Expired - Fee Related CN106535911B (zh) | 2015-07-08 | 2016-06-13 | 含有作为活性成分的桑白皮提取物与卫矛提取物的牙周炎预防及治疗用口腔组合物 |
Country Status (3)
| Country | Link |
|---|---|
| KR (1) | KR101641213B1 (zh) |
| CN (1) | CN106535911B (zh) |
| WO (1) | WO2017007140A1 (zh) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR102022006B1 (ko) | 2017-09-07 | 2019-09-18 | 태이생명과학 주식회사 | 아스퍼질러스 나이거 분리 효소 처리된 황금 추출물을 유효성분으로 포함하는 치주질환 예방 또는 치료용 조성물 |
| KR20190058127A (ko) | 2017-11-21 | 2019-05-29 | 동의대학교 산학협력단 | 산청목 추출물을 포함하는 구강질환의 예방 또는 치료용 조성물 |
| KR102097387B1 (ko) | 2018-05-04 | 2020-04-06 | 원광대학교산학협력단 | 흑미를 유효성분으로 하는 구강질환 예방 및 치료를 위한 조성물 |
| KR102166701B1 (ko) | 2018-06-18 | 2020-10-16 | 스노우화이트팩토리(주) | 아스퍼질러스 나이거 균주를 이용한 황금 발효 추출물을 유효성분으로 포함하는 치주 질환 예방 또는 치료용 조성물 |
| KR20210133852A (ko) * | 2020-04-29 | 2021-11-08 | 한국 한의학 연구원 | 화살나무 추출물을 유효성분으로 함유하는 골질환의 예방, 개선 또는 치료용 조성물 |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107073061A (zh) * | 2015-05-15 | 2017-08-18 | 大韩民国（环境部国立生物资源馆） | 含有作为活性成分的桑白皮提取物与卫矛提取物的龋齿预防及治疗用口腔组合物 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20020082308A (ko) * | 2001-04-20 | 2002-10-31 | 강중열 | 귀전우 추출물을 함유하는 구강용 조성물 |
| KR20020087225A (ko) * | 2001-05-14 | 2002-11-22 | (주)바이오케어 | 구강 병원성균에 대한 항균제 |
| KR20110131498A (ko) * | 2010-05-31 | 2011-12-07 | 김선일 | 패각 또는 패산호로부터 추출한 알카리용액에 은이온을 포함하는 항균제와 이를 포함하여 조성된 조성물. |
| JP2014111652A (ja) * | 2014-02-28 | 2014-06-19 | Lotte Co Ltd | メチオニナーゼ阻害剤及びそれを含有する口腔用組成物並びに飲食品 |
-
2015
- 2015-07-08 KR KR1020150096890A patent/KR101641213B1/ko active IP Right Grant
-
2016
- 2016-06-13 CN CN201680000808.7A patent/CN106535911B/zh not_active Expired - Fee Related
- 2016-06-13 WO PCT/KR2016/006266 patent/WO2017007140A1/ko active Application Filing
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107073061A (zh) * | 2015-05-15 | 2017-08-18 | 大韩民国（环境部国立生物资源馆） | 含有作为活性成分的桑白皮提取物与卫矛提取物的龋齿预防及治疗用口腔组合物 |
Non-Patent Citations (1)
| Title |
|---|
| Kuwanon G: an antibacterial agent from the root bark of Morus alba against oral pathogens;K.M.Park等;《Journal of ethnopharmacology》;20031231(第84期);第181-185页，尤其是摘要、表2 * |
Also Published As
| Publication number | Publication date |
|---|---|
| WO2017007140A1 (ko) | 2017-01-12 |
| KR101641213B1 (ko) | 2016-07-20 |
| CN106535911A (zh) | 2017-03-22 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| KR100835899B1 (ko) | 생강 추출물 또는 이로부터 분리된 진저롤을 포함하는치주질환의 예방 또는 치료용 조성물 | |
| CN106535911B (zh) | 含有作为活性成分的桑白皮提取物与卫矛提取物的牙周炎预防及治疗用口腔组合物 | |
| KR100829045B1 (ko) | 독활 추출물 또는 이로부터 분리된 화합물을 포함하는치주질환의 예방 또는 치료용 조성물 | |
| CN107073061B (zh) | 含有作为活性成分的桑白皮提取物与卫矛提取物的龋齿预防及治疗用口腔组合物 | |
| KR102408893B1 (ko) | 갈화 추출물을 포함하는 구강질환 예방 또는 치료용 조성물 | |
| KR101778058B1 (ko) | 구취 유발균 및 구강내 점막 감염증에 대한 유효 성분으로 천연 약재 추출물을 함유하는 구강 위생 증진용 조성물 | |
| KR102562835B1 (ko) | 금앵자 추출물을 포함하는 구강질환 예방 또는 치료용 조성물 | |
| KR20170141034A (ko) | 인삼 추출물을 포함하는 구강질환 예방 또는 치료용 조성물 | |
| KR101881636B1 (ko) | 갈화 추출물을 포함하는 구강질환 예방 또는 치료용 조성물 | |
| KR20170142740A (ko) | 천연 복합물을 포함하는 구강질환 예방 또는 치료용 조성물 | |
| KR102632336B1 (ko) | 팥꽃 추출물을 포함하는 구강질환 예방 또는 치료용 조성물 | |
| KR102415612B1 (ko) | 과체 추출물을 포함하는 구강질환 예방 또는 치료용 조성물 | |
| KR102132873B1 (ko) | 청대, 오약, 천초 및 파고지 추출물을 포함하는 구강질환 예방 또는 치료용 조성물 | |
| KR102417082B1 (ko) | 청상자 추출물을 포함하는 구강질환 예방 또는 치료용 조성물 | |
| KR102156884B1 (ko) | 천련자 추출물을 포함하는 구강질환 예방 또는 치료용 조성물 | |
| KR102562831B1 (ko) | 조협 추출물을 포함하는 구강질환 예방 또는 치료용 조성물 | |
| KR102562830B1 (ko) | 지부자 추출물을 포함하는 구강질환 예방 또는 치료용 조성물 | |
| KR102562829B1 (ko) | 고량강 추출물을 포함하는 구강질환 예방 또는 치료용 조성물 | |
| KR20170103482A (ko) | 연전초 추출물을 포함하는 구강질환 예방 또는 치료용 조성물 | |
| KR20170120411A (ko) | 스코폴레틴을 포함하는 구강질환 예방 또는 치료용 조성물 | |
| KR102632335B1 (ko) | 지모 추출물을 포함하는 구강질환 예방 또는 치료용 조성물 | |
| KR102495895B1 (ko) | 생강 추출물을 포함하는 구강질환 예방 또는 치료용 조성물 | |
| KR101818211B1 (ko) | 우방자 추출물을 포함하는 구강질환 예방 또는 치료용 조성물 | |
| KR20200107917A (ko) | 천련자 추출물을 포함하는 구강질환 예방 또는 치료용 조성물 | |
| KR20170142975A (ko) | 익모초 추출물을 포함하는 구강질환 예방 또는 치료용 조성물 |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| GR01 | Patent grant | ||
| GR01 | Patent grant | ||
| CF01 | Termination of patent right due to non-payment of annual fee | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20200505 |