CN106491938A - 一种用于乳腺增生的中药组合物 - Google Patents
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Abstract
本发明公开了一种用于乳腺增生的中药组合物,其原料按重量份包括:香附24~27份,柴胡18~21份,川楝子1~3份,青皮6~9份,香橼3~6份,陈皮12~15份,浙贝母9~12份,天葵子3~6份,海浮石12~15份,漏芦6~9份,红花6~9份,刘寄奴3~6份,王不留行6~9份,红藤6~9份,党参12~15份,穿心莲1~2份,甘草3~5份。本发明提出的用于乳腺增生的中药组合物,配伍合理,疗效显著,复发率低,可有效治疗乳腺增生,而且其毒副作用小,价格低廉。
Description
技术领域
本发明涉及技术领域,尤其涉及一种用于乳腺增生的中药组合物。
背景技术
乳腺增生是指乳腺上皮和纤维组织增生,乳腺组织导管和乳小叶在结构上的退行性病变及进行性结缔组织的生长,其发病原因主要是由于内分泌激素失调。乳腺增生症是女性最常见的乳房疾病,其发病率占乳腺疾病的首位。近些年来该病发病率呈逐年上升的趋势,年龄也越来越低龄化。据调查约有70~80%的女性都有不同程度的乳腺增生,多见于25~45岁的女性。
乳腺增生是一种妇科常见的疾病。好发于25~39岁左右的中年妇女,因为这段时间是女性性机能最旺盛的时期。表现为乳房的不同部位单发或多发地生长一些肿块,质地柔软,边界不清,可活动,常伴有不同程度的疼痛。尤其在月经前、劳累后或是生气(中医称气郁)等情绪波动时,肿块增大,疼痛加重,而在月经后肿块明显缩小,疼痛减轻。疼痛一般是胀痛,很少有刺痛感。应该提醒的是,乳腺增生有转变为乳腺痛的可能,所以如果患乳腺有增生时间较长者则应去医院检查,以便及时诊断和治疗。
发明内容
基于背景技术存在的技术问题,本发明提出了一种用于乳腺增生的中药组合物,配伍合理,疗效显著,复发率低,可有效治疗乳腺增生,而且其毒副作用小,价格低廉。
本发明提出的一种用于乳腺增生的中药组合物,其原料按重量份包括:香附24~27份,柴胡18~21份,川楝子1~3份,青皮6~9份,香橼3~6份,陈皮12~15份,浙贝母9~12份,天葵子3~6份,海浮石12~15份,漏芦6~9份,红花6~9份,刘寄奴3~6份,王不留行6~9份,红藤6~9份,党参12~15份,穿心莲1~2份,甘草3~5份。
香附,味辛、微苦、甘,性平。入肝、三焦经。能理气解郁,调经止痛。用于肝郁气滞,胸、胁、脘腹胀痛,消化不良,月经不调,经闭痛经,寒疝腹痛,乳房胀痛。
柴胡,味苦,性微寒,归肝、胆经。能和解表里,疏肝,升阳。用于感冒发热,寒热往来,胸胁胀痛,月经不调,子宫脱垂,脱肛。
川楝子,味苦,性寒。归肝、小肠、膀胱经。能舒肝行气止痛,驱虫。用于胸胁、脘腹胀痛,疝痛,虫积腹痛。
青皮,味苦、辛,性温。入肝、胆、胃经。能疏肝破气、消积化滞。用于胸肋脘胀痛,乳痈、疝痛,食积气滞。
香橼,味辛、苦、酸,性温。归肝、肺、脾经。能理气降逆,宽胸化痰。主治胸腹满闷;胁肋胀痛;咳嗽痰多。
陈皮,味辛、苦,性温。归脾、肺经。能理气健脾,调中,燥湿,化痰。主治脾胃气滞之脘腹胀满或疼痛、消化不良;湿浊阻中之胸闷腹胀、纳呆便溏;痰湿壅肺之咳嗽气喘。
浙贝母,味苦,性寒,归心经、肺经。能清热化痰,散结解毒。主治风热咳嗽,肺痈喉痹,瘰疬,疮疡肿毒。
天葵子,味甘、苦,性寒。归肝、胃经。能清热解毒,消肿散结。用于痈肿疔疮,乳痈,瘰疠,毒蛇咬伤。
海浮石,味咸,性平。入肝经。能清肺化痰,软坚散结。主治痰热喘嗽,老痰积块,题瘤,瘰疬,淋病,疝气,疮肿,目翳。
漏芦,味苦,性寒。入胃经。能清热解毒,消痈,下乳,舒筋通脉。用于乳痈肿痛,痈疽发背,瘰疬疮毒,乳汁不通,湿痹拘挛。
红花,味辛,性温。归肝、心经。能活血通经,散瘀止痛。用于经闭,痛经,恶露不行,症瘕痞块,跌扑损伤,疮疡肿痛。
刘寄奴,味苦,性温。归心、脾经。能破血通经,敛疮消肿。主治经闭症瘕,胸腹胀痛,产后血瘀,跌打损伤,金疮出血,痈毒焮肿。
王不留行,味苦,性平。归肝,胃经。能活血通经,下乳消痈,利尿通淋。主治血瘀经闭,痛经,难产;产后乳汁不下,乳痈肿痛;热淋,血淋,石淋。
红藤,味苦,性平,入大肠经。具有清热解毒、活血散瘀、祛风杀虫的功效。用于肠痈腹痛、风湿痹痛、跌打伤痛,妇女痛经,赤痢,血淋,疳积虫痛等症。
党参,味甘、微酸,性平。归脾、肺经。能补中益气,健脾益肺。用于脾肺虚弱,气短心悸,食少便溏,虚喘咳嗽,内热消渴。
穿心莲,味苦,性寒。归心、肺、大肠、膀胱经。具有清热解毒,凉血,消肿,燥湿的功效。主治感冒发热,咽喉肿痛,口舌生疮,顿咳劳嗽,泄泻痢疾,热淋涩痛,痈肿疮疡,毒蛇咬伤。
甘草,味甘,性平,归十二经。能补脾益气,清热解毒,祛痰止咳,缓急止痛,调和诸药。用于脾胃虚弱,倦怠乏力,心悸气短,咳嗽痰多,脘腹、四肢挛急疼痛,痈肿疮毒,缓解药物毒性、烈性。
优选地,香附、柴胡、川楝子的重量比为25~26:19~20:1.5~2.5。
优选地,其原料按重量份包括:香附25~26份,柴胡19~20份,川楝子1.5~2.5份,青皮7~8份,香橼4~5份,陈皮13~14份,浙贝母10~11份,天葵子4~5份,海浮石13~14份,漏芦7~8份,红花7~8份,刘寄奴4~5份,王不留行7~8份,红藤7~8份,党参13~14份,穿心莲1.2~1.8份,甘草3.5~4.5份。
优选地,青皮、香橼、陈皮、浙贝母、天葵子、海浮石、漏芦的重量比为5:3:9:7:3:9:5。
优选地,红花、刘寄奴、王不留行、红藤的重量比为5:3:5:5。
优选地,其原料按重量份包括:香附25.5份,柴胡19.5份,川楝子2份,青皮7.5份,香橼4.5份,陈皮13.5份,浙贝母10.5份,天葵子4.5份,海浮石13.5份,漏芦7.5份,红花7.5份,刘寄奴4.5份,王不留行7.5份,红藤7.5份,党参13.5份,穿心莲1.5份,甘草4份。
本发明制备方法如下:将上述药物混合后,加水,武火煮沸,再用文火煎煮1~2h,冷却,滤去药渣即得。
乳络为肝胃所主,因肝郁胃阻,而乳络不畅,日久则痰聚血凝成癖,发为乳腺增生,肝郁气血失畅,累及冲任,故月经不调,女性乳房属于生殖系统,故冲任失调又反之累及乳络,故乳病症状随月经而变化。综上所述,乳癖之病为肝气郁结,冲任失调,而致气滞痰凝血瘀于乳络,结成乳癖。
本发明采用香附、柴胡、川楝子相互配合,舒肝行气,理气解郁,调经止痛;以青皮、香橼、陈皮、浙贝母、天葵子、海浮石、漏芦相互配合,疏肝破气,理气健脾,软坚散结,清热解毒,舒筋通脉,而红花、刘寄奴、王不留行、红藤相互配合,活血通经,散瘀止痛,下乳消痈,;再以党参补中益气,健脾益肺,穿心莲清热消肿,甘草调和诸药;上述诸药配合,能够肝气畅达而气血流通,化痰祛瘀,软坚散结而标本兼顾。
具体实施方式
下面,通过具体实施例对本发明的技术方案进行详细说明。
实施例1
本发明提出的一种用于乳腺增生的中药组合物,其原料按重量份包括:香附24份,柴胡21份,川楝子1份,青皮9份,香橼3份,陈皮15份,浙贝母9份,天葵子6份,海浮石12份,漏芦9份,红花6份,刘寄奴6份,王不留行6份,红藤9份,党参12份,穿心莲2份,甘草3份。
实施例2
本发明提出的一种用于乳腺增生的中药组合物,其原料按重量份包括:香附27份,柴胡18份,川楝子3份,青皮6份,香橼6份,陈皮12份,浙贝母12份,天葵子3份,海浮石15份,漏芦6份,红花9份,刘寄奴3份,王不留行9份,红藤6份,党参15份,穿心莲1份,甘草5份。
实施例3
本发明提出的一种用于乳腺增生的中药组合物,其原料按重量份包括:香附25份,柴胡20份,川楝子1.5份,青皮8份,香橼4份,陈皮14份,浙贝母10份,天葵子5份,海浮石13份,漏芦8份,红花7份,刘寄奴5份,王不留行7份,红藤8份,党参13份,穿心莲1.8份,甘草3.5份。
实施例4
本发明提出的一种用于乳腺增生的中药组合物,其原料按重量份包括:香附26份,柴胡19份,川楝子2.5份,青皮7份,香橼5份,陈皮13份,浙贝母11份,天葵子4份,海浮石14份,漏芦7份,红花8份,刘寄奴4份,王不留行8份,红藤7份,党参14份,穿心莲1.2份,甘草4.5份。
实施例5
本发明提出的一种用于乳腺增生的中药组合物,其原料按重量份包括:香附25.5份,柴胡19.5份,川楝子2份,青皮7.5份,香橼4.5份,陈皮13.5份,浙贝母10.5份,天葵子4.5份,海浮石13.5份,漏芦7.5份,红花7.5份,刘寄奴4.5份,王不留行7.5份,红藤7.5份,党参13.5份,穿心莲1.5份,甘草4份。
采用实施例5所得中药组合物进行人体临床实验:
通过筛选女性门诊患者,选择确诊为乳腺增生的患者120例,年龄最小者28岁,年龄最大者54岁,患者均知情同意参与实验。随机分成两组,对照组口服乳癖消,一次5~6片,一日3次;实验组口服本发明实施例5所得中药煎剂,每日一次。7天一个疗程,6个疗程治疗后,结果如下:
组别 | n | 痊愈 | 显效 | 有效 | 总有效率 | 无效 |
实验组 | 60 | 33 | 15 | 10 | 96.67% | 2 |
对照组 | 60 | 21 | 14 | 14 | 81.67% | 11 |
由上表可知:本发明所得药剂的疗效显著,优于现有技术。
随访半年,实验组33例痊愈患者,复发5例;对照组21例痊愈患者,复发7例,由此可知本发明复发率低。
其中疗效标准参照《中医病症判断疗效标准》中有关疗效标准:
治愈:临床症状全部消失,实验室检查正常。
显效:临床症状基本消失,试验室检查各相关指标接近正常水平。
有效:临床症状减轻,试验室检查各相关指标有所改善,体征有改善。
无效:临床症状无明显好转或加重。
以上所述,仅为本发明较佳的具体实施方式,但本发明的保护范围并不局限于此,任何熟悉本技术领域的技术人员在本发明揭露的技术范围内,根据本发明的技术方案及其发明构思加以等同替换或改变,都应涵盖在本发明的保护范围之内。
Claims (6)
1.一种用于乳腺增生的中药组合物,其特征在于,其原料按重量份包括:香附24~27份,柴胡18~21份,川楝子1~3份,青皮6~9份,香橼3~6份,陈皮12~15份,浙贝母9~12份,天葵子3~6份,海浮石12~15份,漏芦6~9份,红花6~9份,刘寄奴3~6份,王不留行6~9份,红藤6~9份,党参12~15份,穿心莲1~2份,甘草3~5份。
2.根据权利要求1所述用于乳腺增生的中药组合物,其特征在于,香附、柴胡、川楝子的重量比为25~26:19~20:1.5~2.5。
3.根据权利要求1或2所述用于乳腺增生的中药组合物,其特征在于,其原料按重量份包括:香附25~26份,柴胡19~20份,川楝子1.5~2.5份,青皮7~8份,香橼4~5份,陈皮13~14份,浙贝母10~11份,天葵子4~5份,海浮石13~14份,漏芦7~8份,红花7~8份,刘寄奴4~5份,王不留行7~8份,红藤7~8份,党参13~14份,穿心莲1.2~1.8份,甘草3.5~4.5份。
4.根据权利要求1-3任一项所述用于乳腺增生的中药组合物,其特征在于,青皮、香橼、陈皮、浙贝母、天葵子、海浮石、漏芦的重量比为5:3:9:7:3:9:5。
5.根据权利要求1-4任一项所述用于乳腺增生的中药组合物,其特征在于,红花、刘寄奴、王不留行、红藤的重量比为5:3:5:5。
6.根据权利要求1-5任一项所述用于乳腺增生的中药组合物,其特征在于,其原料按重量份包括:香附25.5份,柴胡19.5份,川楝子2份,青皮7.5份,香橼4.5份,陈皮13.5份,浙贝母10.5份,天葵子4.5份,海浮石13.5份,漏芦7.5份,红花7.5份,刘寄奴4.5份,王不留行7.5份,红藤7.5份,党参13.5份,穿心莲1.5份,甘草4份。
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