CN106474418A - 用于治疗胃病的中药组合物及其制备方法 - Google Patents
用于治疗胃病的中药组合物及其制备方法 Download PDFInfo
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- CN106474418A CN106474418A CN201611234156.1A CN201611234156A CN106474418A CN 106474418 A CN106474418 A CN 106474418A CN 201611234156 A CN201611234156 A CN 201611234156A CN 106474418 A CN106474418 A CN 106474418A
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Abstract
本发明提供一种治疗胃病的中药组合物,按质量百分比由以下组分组成:佛手6%~8%、牡蛎5%~7%、葛根5%~7%、小茴香3%~4%、代代花3%~4%、山药5%~7%、淡豆豉5%~7%、麦芽5%~7%、大枣5%~7%、甘草3%~4%、黑胡椒3%~4%、丁香3%~4%、山楂5%~7%、藿香5%~7%、鸡内金5%~7%、砂仁3%~4%、肉豆蔻5%~7%、肉桂3%~4%、枳椇子6%~8%,以上各组份的质量百分比总和为100%。将上述组份混合后加水熬成膏状后与麦芽糊精以及山梨酸钾混合制粒,干燥,灭菌,即成。采取口服治疗方式,对于慢性胃炎、胃及十二指肠溃疡有良好的治疗作用,具有无毒副作用,疗效好,不易复发的特点。
Description
技术领域
本发明属于药食同源范畴的中药组合物,具体涉及一种用于治疗胃病的中药组合物及其制备方法。
背景技术
胃病是人群中最多见的却最难治的疾病之一,多见急慢性胃炎、胃及十二指肠溃疡病;工作过度紧张、食无定时、吃饱后马上工作或运动、饮酒过多、吃辣过度、经常进食难消化的食物都会引起胃病,上述饮食和习惯可导致胃酸过度分泌而破坏胃、十二指肠的保护层,从而产生溃疡。胃病的主要症状表现为上腹痛、反酸、气胀、恶心呕吐,一般需要经过较长时间的治疗。目前治疗胃炎、胃及十二指肠溃疡病的方法有中医治疗和西医治疗,针对胃炎西医治疗一般以阿莫西林+奥美拉唑+甲硝唑,即三联疗法,制酸抗感染为主,基本只能缓解或者解除症状;针对胃及十二指肠溃疡病,采用的药物有铝镁凝胶、斯达舒等。长期服用西药,有伤胃气,导致患者不思饮食,营养不良,还有皮疹、腹泻、肝损害等不良反应。中医治疗胃病以寒热虚实、寒热错杂为治病范畴比较常见,但忽视了脾胃久虚,积淤不畅等症,仅仅平衡脾胃阴阳是不够,因此导致疗效不佳,大多数患者反馈仅是胃痛症状消失,但是饮食量不增,且消化吸收没有得到改善。
发明内容
本发明的目的是提供一种治疗胃病的中药组合物,采用固体汤药的治疗手段,用于慢性胃炎、胃及十二指肠溃疡的治疗,具有无毒副作用,不复发、治愈率高的特点。
本发明所采用的技术方案是,
用于治疗胃病的中药组合物,其特征在于,按质量百分比由以下组分组成:佛手6%~8%、牡蛎5%~7%、葛根5%~7%、小茴香3%~4%、代代花3%~4%、山药5%~7%、淡豆豉5%~7%、麦芽5%~7%、大枣5%~7%、甘草3%~4%、黑胡椒3%~4%、丁香3%~4%、山楂5%~7%、藿香5%~7%、鸡内金5%~7%、砂仁3%~4%、肉豆蔻5%~7%、肉桂3%~4%、枳椇子6%~8%,以上各组份的质量百分比总和为100%。
上述用于治疗胃病中药组合物的制备方法,包括以下操作步骤:
步骤1,
按质量百分比,称取佛手6%~8%、牡蛎5%~7%、葛根5%~7%、小茴香3%~4%、代代花3%~4%、山药5%~7%、淡豆豉5%~7%、麦芽5%~7%、大枣5%~7%、甘草3%~4%、黑胡椒3%~4%、丁香3%~4%、山楂5%~7%、藿香5%~7%、鸡内金5%~7%、砂仁3%~4%、肉豆蔻5%~7%、肉桂3%~4%、枳椇子6%~8%,以上各组份的质量百分比总和为100%;
步骤2,
将步骤1中的19味原料加水煎煮两次,第一次加10倍量的水,煎煮2小时,第二次加6倍量的水,煎煮2小时,合并两次煎液,过滤,滤液浓缩至相对密度为1.20~1.40(60℃)的稠膏;
步骤3,
另取麦芽糊精和山梨酸钾,并将麦芽糊精和山梨酸钾粉碎过80目,备用;
步骤4,
按质量百分比,称取步骤1得到的稠膏24%~26.97%、麦芽糊精73%~75.97%和山梨酸钾0.01%~0.03%,以上各组份的质量百分比总和为100%;将稠膏与水搅拌均匀得到喷浆,稠膏与水的重量比为1:2;
步骤5,
在多功能流化床中,将麦芽糊精和山梨酸钾进行物料加热预混,得到混合物料,然后往混合物料上喷浆进行制粒,最后烘干、降温、出料、关机;
步骤6,
最后整粒和灌装,即得。
上述步骤5中,将麦芽糊精和山梨酸钾置于多功能流化床中,风量设置为15m3/h~25m3/h,进风温度设置为80℃~100℃,对物料进行加热预混7~15分钟,得到混合物料;预混完毕后,通过调节风量及进风温度,使得混合物料温度达到35℃~40℃,然后多功能流化床开始喷浆,喷浆速度设置为15rpm~20rpm,雾化压力为1.50bar~2.0bar,由于喷浆后物料加重,温度降低,随时调节风量保持物料充分跳跃,并随时调节进风温度使物料温度保持在35℃~40℃,喷浆15min~30min后关闭喷浆,完成制粒;再将多功能流化床的进风温度设置为100℃对物料进行干燥,调节风量保持物料充分跳跃,当物料的水分≤2.0%时,将进风温度降至25℃~45℃,使物料的温度降为25℃~45℃,最后出料关机。
上述步骤6中,将步骤5得到的干颗粒在振荡筛上选取14目~60目之间的颗粒完成整粒,然后将选取的干颗粒装入袋中完成灌装。
本发明的有益效果是:治疗慢性胃炎、胃及十二指肠溃疡能在一个疗程内让患者减轻痛苦、缓解症状,并最终通过百日服用达到彻底治愈的目的;诸药合用具有増行气消痞除满、和胃修复胃黏膜损伤、温中理气、健脾和胃、散瘀止血和消肿解毒功效;且本发明中药无毒副作用,治愈率高,无复发。
具体实施方式
本发明提供一种用于治疗胃病的中药组合物,按质量百分比由以下组分组成:佛手6%~8%、牡蛎5%~7%、葛根5%~7%、小茴香3%~4%、代代花3%~4%、山药5%~7%、淡豆豉5%~7%、麦芽5%~7%、大枣5%~7%、甘草3%~4%、黑胡椒3%~4%、丁香3%~4%、山楂5%~7%、藿香5%~7%、鸡内金5%~7%、砂仁3%~4%、肉豆蔻5%~7%、肉桂3%~4%、枳椇子6%~8%,以上各组份的质量百分比总和为100%。
本发明中药的药理作用如下:
佛手:辛,苦,酸,温,归肝脾胃肺经疏肝理气,和胃止痛,燥湿化痰,用于肝胃气滞,胸胁胀痛,胃脘痞满,食少呕吐,咳嗽痰多。
牡蛎:重镇安神,潜阳补阴,软坚散结,用于惊悸失眠,眩晕耳鸣,煅牡蛎收敛固涩,制酸止痛。用于自汗盗汗,遗精滑精,崩漏带下,胃痛吞酸。
葛根:解肌退热,生津止渴,透疹,升阳止泻,通经活络,解酒毒,用于外感发热头痛,项背强痛,口渴,消渴,麻疹不透,热痢,泄泻,眩晕头痛,中风偏瘫,胸痹心痛,酒毒伤中。
小茴香:辛,温。归脾胃肝肾经散寒止痛,理气和胃。用于寒疝腹痛,睾丸偏坠,痛经,少腹冷痛,食少吐泻。
代代花:性微寒,味苦、酸行气宽中,消食,化痰,能舒肝理气,和胃止呕。胸腹闷胀痛、食积不化、痰饮、脱肛、胸胁不舒、恶心呕吐、不思饮食。
山药:甘,平,归皮肺肾经补脾养胃,生津益肺,用于脾虚食少,久泻不止,肺虚喘咳,肾虚遗精,带下,尿频,虚热消渴。麸炒山药补脾健胃。用于脾虚食少,泄泻便溏,白带过多。
淡豆豉:解表,除烦,宣发郁热,用于感冒,寒热头痛,烦躁胸闷,虚烦不眠。
麦芽:甘,平,归脾胃经行气消食,健脾开胃,回乳消胀,用于食积不消,脘腹胀痛,脾虚食少,乳汁郁积,乳房胀痛,妇女断乳,肝郁肋痛,肝胃气痛。
大枣:甘,温,归脾胃心经补中益气,养血安神,用于脾虚食少,乏力便溏,妇人脏躁。
甘草:甘,平。归心肺脾胃经补脾益气,清热解毒,去痰止咳,缓急止痛,调和诸药。用于脾胃虚弱,倦怠乏力,心悸气短,咳嗽痰多,脘腹,四肢挛急疼痛,痈肿疮毒,缓解药物毒性烈性。
黑胡椒:温中散寒,下气,消痰,用于胃寒呕吐,腹痛泄泻,食欲不振,癫痫痰多。
丁香:辛,温。归脾胃肺肾经温中降逆,补肾助阳。用于脾胃虚寒呃逆呕吐,食少止泻,心腹冷痛,肾虚阳痿。
山楂:酸甘微温归脾胃肝经消食健胃,行气散瘀,化浊降脂。用于肉食积滞,胃脘胀满,泻痢腹痛,淤血经闭,产后瘀阻,心腹刺痛,胸痹心痛,疝气疼痛,高脂血症。
藿香:芳香化浊,和中止呕,发表解暑,用于湿浊中阻,脘痞呕吐,暑湿表症,湿温初起,发热倦怠,胸闷不舒,寒湿闭暑,腹痛吐泻,鼻渊头痛。
鸡内金:健胃消食,涩精止遗,通淋化石,用于食积不消,呕吐泻痢,小儿疳积,遗尿,遗精,石林涩痛,胆胀肋痛。
砂仁:化湿开胃,温脾止泻,理气安胎。用于湿浊中阻,脘痞不饥,脾胃虚寒,呕吐泄泻,妊娠恶阻,胎动不安。
肉豆蔻:辛,温,归脾胃大肠经温中行气,涩肠止泻,用于脾胃虚寒,久泻不止,脘腹胀痛,食少呕吐。
肉桂:辛,甘,大热归肾脾心肝经补火助阳,引火归元,散寒止痛,温通经脉,用于阳痿宫冷,腰膝冷痛,肾虚作喘,虚阳上浮,眩晕目赤,心腹冷痛,虚寒吐泻,寒疝腹痛,痛经闭经。
枳椇子:治酒醉,烦热,口渴,呕吐,二便不利。
胃病即慢性胃炎多因脾胃素虚,升降失职,寒热互结,气壅湿聚所致。治宜健脾和胃,消痞除满,平调寒热。根据《中国药典》,方中佛手苦辛温行气消痞为君;代代花苦辛凉行气除满为臣。二者合用,以増行气消痞除满之效。葛根、肉豆蔻、砂仁清热除湿消痞;牡蛎性寒,制酸止痛、软坚散结而和胃,利于修复胃黏膜损伤;加入小茴香、黑胡椒、丁香、肉桂各适量以辛热温中祛寒,八味相伍,平调寒热升降,共助佛代行气消痞除满之功;麦芽、山楂、鸡内金消食和胃;山药、淡豆豉、大枣、藿香,益气健脾、祛湿和中;枳椇子甘酸平,善长护胃解酒毒,缓解饮酒过量及酒后不适;葛根、肉豆蔻、砂仁、牡蛎、小茴香、黑胡椒、丁香、肉桂、麦芽、山楂、鸡内金、山药、淡豆豉、大枣、藿香、枳椇子共为佐药。甘草调和药性,为使。全方消补兼施、寒热升降并举,共奏健脾和胃,消痞除满,平调寒热之功。
本发明中药组合物采用口服的方式,每次口服10克,每天2次,一个月为一个疗程。
下面结合具体实施例对本发明进行详细说明。
实施例1
用于治疗胃病中药组合物的制备方法,包括以下操作步骤:
步骤1,
称取佛手7kg、牡蛎5kg、葛根5kg、小茴香3kg、代代花4kg、山药7kg、淡豆豉7kg、麦芽6kg、大枣6kg、甘草3kg、黑胡椒3kg、丁香4kg、山楂6kg、藿香6kg、鸡内金7kg、砂仁3kg、肉豆蔻7kg、肉桂4kg、枳椇子7kg;
步骤2,
将步骤1中的19味原料加水煎煮两次,第一次加10倍量的水,煎煮2小时,第二次加6倍量的水,煎煮2小时,合并两次煎液,过滤,滤液浓缩至相对密度为1.35(60℃)的稠膏;
步骤3,
另取麦芽糊精和山梨酸钾,并将麦芽糊精和山梨酸钾粉碎过80目,备用;
步骤4,
称取稠膏20.5kg、麦芽糊精61.5kg和山梨酸钾20g;将稠膏与水搅拌均匀得到喷浆,稠膏与水的重量比为1:2;
步骤5,
将麦芽糊精和山梨酸钾置于多功能流化床中,风量设置为20m3/h,进风温度设置为90℃,对物料进行加热预混10分钟,得到混合物料;预混完毕后,通过调节风量及进风温度,使得混合物料温度达到36℃,然后多功能流化床开始喷浆,喷浆速度设置为17rpm,雾化压力为1.70bar,由于喷浆后物料加重,温度降低,随时调节风量保持物料充分跳跃,并随时调节进风温度使物料温度保持在36℃,喷浆20min后关闭喷浆,完成制粒;再将多功能流化床的进风温度设置为100℃对物料进行干燥,调节风量保持物料充分跳跃,当物料的水分≤2.0%时,将进风温度降至25℃,使物料的温度降为25℃,最后出料关机;
步骤6,
将步骤5得到的干颗粒在振荡筛上选取14目~60目之间的颗粒完成整粒,然后将选取的干颗粒装入袋中完成灌装。
实施例2
用于治疗胃病中药组合物的制备方法,包括以下操作步骤:
步骤1,
称取佛手8kg、牡蛎6kg、葛根6kg、小茴香3kg、代代花3kg、山药6kg、淡豆豉6kg、麦芽7kg、大枣5kg、甘草4kg、黑胡椒3kg、丁香3kg、山楂7kg、藿香7kg、鸡内金6kg、砂仁4kg、肉豆蔻6kg、肉桂3kg、枳椇子7kg;
步骤2,
将步骤1中的19味原料加水煎煮两次,第一次加10倍量的水,煎煮2小时,第二次加6倍量的水,煎煮2小时,合并两次煎液,过滤,滤液浓缩至相对密度为1.20(60℃)的稠膏;
步骤3,
另取麦芽糊精和山梨酸钾,并将麦芽糊精和山梨酸钾粉碎过80目,备用;
步骤4,
称取稠膏24kg、麦芽糊精75.97kg和山梨酸钾30g;将稠膏与水搅拌均匀得到喷浆,稠膏与水的重量比为1:2;
步骤5,
将麦芽糊精和山梨酸钾置于多功能流化床中,风量设置为25m3/h,进风温度设置为80℃,对物料进行加热预混7分钟,得到混合物料;预混完毕后,通过调节风量及进风温度,使得混合物料温度达到40℃,然后多功能流化床开始喷浆,喷浆速度设置为15rpm,雾化压力为1.50bar,由于喷浆后物料加重,温度降低,随时调节风量保持物料充分跳跃,并随时调节进风温度使物料温度保持在40℃,喷浆15min后关闭喷浆,完成制粒;再将多功能流化床的进风温度设置为100℃对物料进行干燥,调节风量保持物料充分跳跃,当物料的水分≤2.0%时,将进风温度降至35℃,使物料的温度降为35℃,最后出料关机;
步骤6,
将步骤5得到的干颗粒在振荡筛上选取14目~60目之间的颗粒完成整粒,然后将选取的干颗粒装入袋中完成灌装。
实施例3
用于治疗胃病中药组合物的制备方法,包括以下操作步骤:
步骤1,
称取佛手7kg、牡蛎7kg、葛根7kg、小茴香4kg、代代花4kg、山药5kg、淡豆豉7kg、麦芽5kg、大枣7kg、甘草4kg、黑胡椒4kg、丁香4kg、山楂5kg、藿香5kg、鸡内金6kg、砂仁4kg、肉豆蔻5kg、肉桂4kg、枳椇子6kg;
步骤2,
将步骤1中的19味原料加水煎煮两次,第一次加10倍量的水,煎煮2小时,第二次加6倍量的水,煎煮2小时,合并两次煎液,过滤,滤液浓缩至相对密度为1.30(60℃)的稠膏;
步骤3,
另取麦芽糊精和山梨酸钾,并将麦芽糊精和山梨酸钾粉碎过80目,备用;
步骤4,
称取稠膏26.97kg、麦芽糊精73kg和山梨酸钾30g;将稠膏与水搅拌均匀得到喷浆,稠膏与水的重量比为1:2;
步骤5,
将麦芽糊精和山梨酸钾置于多功能流化床中,风量设置为15m3/h,进风温度设置为100℃,对物料进行加热预混12分钟,得到混合物料;预混完毕后,通过调节风量及进风温度,使得混合物料温度达到38℃,然后多功能流化床开始喷浆,喷浆速度设置为18rpm,雾化压力为2.0bar,由于喷浆后物料加重,温度降低,随时调节风量保持物料充分跳跃,并随时调节进风温度使物料温度保持在38℃,喷浆30min后关闭喷浆,完成制粒;再将多功能流化床的进风温度设置为100℃对物料进行干燥,调节风量保持物料充分跳跃,当物料的水分≤2.0%时,将进风温度降至30℃,使物料的温度降为30℃,最后出料关机;
步骤6,
将步骤5得到的干颗粒在振荡筛上选取14目~60目之间的颗粒完成整粒,然后将选取的干颗粒装入袋中完成灌装。
实施例4
用于治疗胃病中药组合物的制备方法,包括以下操作步骤:
步骤1,
称取佛手6kg、牡蛎6kg、葛根7kg、小茴香4kg、代代花3kg、山药5kg、淡豆豉5kg、麦芽6kg、大枣6kg、甘草3kg、黑胡椒4kg、丁香4kg、山楂7kg、藿香7kg、鸡内金5kg、砂仁3kg、肉豆蔻7kg、肉桂4kg、枳椇子8kg;
步骤2,
将步骤1中的19味原料加水煎煮两次,第一次加10倍量的水,煎煮2小时,第二次加6倍量的水,煎煮2小时,合并两次煎液,过滤,滤液浓缩至相对密度为1.40(60℃)的稠膏;
步骤3,
另取麦芽糊精和山梨酸钾,并将麦芽糊精和山梨酸钾粉碎过80目,备用;
步骤4,
称取稠膏24.02kg、麦芽糊精75.97kg和山梨酸钾10g;将稠膏与水搅拌均匀得到喷浆,稠膏与水的重量比为1:2;
步骤5,
将麦芽糊精和山梨酸钾置于多功能流化床中,风量设置为20m3/h,进风温度设置为95℃,对物料进行加热预混15分钟,得到混合物料;预混完毕后,通过调节风量及进风温度,使得混合物料温度达到35℃,然后多功能流化床开始喷浆,喷浆速度设置为20rpm,雾化压力为1.70bar,由于喷浆后物料加重,温度降低,随时调节风量保持物料充分跳跃,并随时调节进风温度使物料温度保持在35℃,喷浆25min后关闭喷浆,完成制粒;再将多功能流化床的进风温度设置为100℃对物料进行干燥,调节风量保持物料充分跳跃,当物料的水分≤2.0%时,将进风温度降至45℃,使物料的温度降为45℃,最后出料关机;
步骤6,
将步骤5得到的干颗粒在振荡筛上选取14目~60目之间的颗粒完成整粒,然后将选取的干颗粒装入袋中完成灌装。
一、本发明药物治疗胃及十二指肠溃疡的临床资料:
1、病例选择:
近年观察225例经X线钡剂或胃镜检查确诊的胃及十二指肠溃疡。男120例,女105例,年龄最小20岁,最大56岁,平均35岁;病程最短6个月,最长2年;胃溃疡138例,十二指肠溃疡87例。
主要症状:上腹疼痛或“烧心”感,饭后缓解,胃反酸,平时腹脘涨满。
2、治疗方法:
口服本发明中药,每次口服10克,每天2次,一个月为一个疗程。
3、疗效判定:
治愈:体征及症状完全改善,上腹部疼痛消失,内镜检查,溃疡面白苔已消失,变成红色充血瘢痕,病变部位恢复正常。
显效:胃痛消失或缓解,其他症状显著减轻,内镜检查,溃疡面积缩小,其周围可见粘膜上皮再生的红晕,病变部位明显改善。
无效:体征及症状无改变,症状如前。
4、结果:
临床观察治疗胃溃疡138例;十二指肠溃疡87例。服用本发明中药治疗胃及十二指肠溃疡,每日2次,每次10g,1个月为1疗程,3个疗程后治疗效果如表1所示;
表1
治疗人数 | 治愈 | 显效 | 无效 | |
胃溃疡 | 138 | 126 | 10 | 2 |
十二指肠溃疡 | 87 | 78 | 7 | 2 |
所收治的225例病例中,经3个疗程的治疗,其中治愈204例,显效17例,无效4例,总有效率达98.2%。结果表明,本发明的中药对治疗胃溃疡及十二指肠溃疡患者有极其显著疗效。
二、本发明药物治疗慢性胃炎的临床资料:
1、病例选择:
近年观察150例慢性胃炎病例,男80例,女70例,年龄最小20岁,最大65岁,平均40岁,病程最短3个月,最长2年。
主要症状:上腹部呈烧灼性疼痛或胀痛,疼痛可以因进食而加剧,胃反酸,恶心呕吐、食欲不振、脘腹胀满、嗳气乏力,有时可伴有腹泻、发热畏寒、脱水等全身症状。胃镜检查可见胃体黏膜有不同程度的点片状充血、水肿或糜烂、红白相间或见胃黏膜色泽改变、皱襞变细、平坦、静脉血管显露。
2、治疗方法:
口服本发明中药,每次口服10克,每天2次,一个月为一个疗程。
3、疗效判定:
治愈:临床症状消失,胃镜检查发现胃黏膜病变消失;
显效:临床症状减轻,胃镜检查胃黏膜病变基本消失或有明显改善;
无效:临床症状无明显改善,胃镜检查结果无明显变化。
4、结果:
临床观察治疗慢性胃炎150例;服用本发明中药治疗慢性胃炎,每日2次,每次10g,1个月为1疗程,3个疗程后治疗效果如表2所示;
表2
治疗人数 | 治愈 | 显效 | 无效 | |
胃溃疡 | 150 | 130 | 17 | 3 |
所收治的150例病例中,经3个疗程治疗后,其中治愈130例,显效17例,无效3例,总有效率达98%。结果表明,本发明的中药对治疗慢性胃炎患者有极其显著疗效。
病例1
李某,女,40岁,延安市宝塔区七里铺街人。患胃病3余年,时常嗳气、呕吐、反酸、疼痛,经胃镜检查确认为胃溃疡,胃部有红斑,并有多处溃疡和糜烂点;服用本发明中药,每天2次,每次口服10克,忌辛辣、动物油和烟酒;20天后恶心呕吐的症状消失,30天后明显好转,连服3个疗程,经胃镜复查,胃内红斑、糜烂症状完全消失。
病例2
陈某,男,29岁,榆林市文化北路人。自述:经常感觉到胃痛,空腹时加剧,近期出现上腹痛、吃饭没胃口、暖气、恶心、胃反酸,诊为慢性胃炎。服用本发明中药1个疗程,胃痛、呕吐的症状得到缓解,继续服用2个疗程,症状完全消失,治愈。
病例3
张某,男,47岁,镇安县后街人,有饮酒史。自述:2个月前出现上腹部阵发疼痛,痛时攻窜左胁,嗳气、大便不畅、舌苔薄白、脉沉弦。胃镜检查显示十二指肠球部溃疡、胃黏膜糜烂;服用本发明中药,三十天为一疗程,连续服用两个疗程后,临床症状消失,继续服用一个疗程后,胃镜检查显示胃黏膜溃疡面完全修复愈合,一年内未复发。
病例4
吴某,女,56岁,高陵县通远镇郭路村人。自述:一个月前上腹部疼痛,呈持续性钝痛,并伴有恶心、呕吐、胃反酸症状,开始时吐胃内容物,后来慢慢开始吐黄色胆汁。检查:患者上腹部压痛阳性,经胃肠道X线钡餐检查确诊为胃溃疡。服用本发明中药,服用方法:每天两次,每次10g,一个月为一个疗程。治疗两个疗程后,患者腹痛明显减轻,恶心、呕吐现象消失;继续用药一个疗程后,患者胃部溃疡面愈合,患者症状解除,三个月后复查,无复发。
病例5
刘某,男,61岁,渭南市华县人。自述:上腹部疼痛已1年有余,空腹时症状加重,伴有嗳气、胃反酸等症状,经常发作;曾经服用斯达舒药物,开始时病情有缓解,病情经常反复发作。检查:患者上腹部隐隐作痛,全身乏力,大便溏薄,舌质淡,苔薄白,脉细。经胃肠道X线钡餐检查发现十二指肠溃疡。服用本发明中药,服用方法:每天两次,每次10g,一个月为一个疗程。用药一个疗程后,患者腹痛消失,患者精神状态明显好转,部分症状及体征消失,继续用药两个疗程,患者痊愈。三个月后回访,无复发。
Claims (4)
1.用于治疗胃病的中药组合物,其特征在于,按质量百分比由以下组分组成:佛手6%~8%、牡蛎5%~7%、葛根5%~7%、小茴香3%~4%、代代花3%~4%、山药5%~7%、淡豆豉5%~7%、麦芽5%~7%、大枣5%~7%、甘草3%~4%、黑胡椒3%~4%、丁香3%~4%、山楂5%~7%、藿香5%~7%、鸡内金5%~7%、砂仁3%~4%、肉豆蔻5%~7%、肉桂3%~4%、枳椇子6%~8%,以上各组份的质量百分比总和为100%。
2.一种权利要求1所述用于治疗胃病中药组合物的制备方法,其特征在于,包括以下操作步骤:
步骤1,
按质量百分比,称取佛手6%~8%、牡蛎5%~7%、葛根5%~7%、小茴香3%~4%、代代花3%~4%、山药5%~7%、淡豆豉5%~7%、麦芽5%~7%、大枣5%~7%、甘草3%~4%、黑胡椒3%~4%、丁香3%~4%、山楂5%~7%、藿香5%~7%、鸡内金5%~7%、砂仁3%~4%、肉豆蔻5%~7%、肉桂3%~4%、枳椇子6%~8%,以上各组份的质量百分比总和为100%;
步骤2,
将步骤1中的19味原料加水煎煮两次,第一次加10倍量的水,煎煮2小时,第二次加6倍量的水,煎煮2小时,合并两次煎液,过滤,滤液浓缩至相对密度为1.20~1.40(60℃)的稠膏;
步骤3,
另取麦芽糊精和山梨酸钾,并将麦芽糊精和山梨酸钾粉碎过80目,备用;
步骤4,
按质量百分比,称取步骤1得到的稠膏24%~26.97%、麦芽糊精73%~75.97%和山梨酸钾0.01%~0.03%,以上各组份的质量百分比总和为100%;将稠膏与水搅拌均匀得到喷浆,稠膏与水的重量比为1:2;
步骤5,
在多功能流化床中,将麦芽糊精和山梨酸钾进行物料加热预混,得到混合物料,然后往混合物料上喷浆进行制粒,最后烘干、降温、出料、关机;
步骤6,
最后整粒和灌装,即得。
3.根据权利要求2所述用于治疗胃病中药组合物的制备方法,其特征在于:所述步骤5中,将麦芽糊精和山梨酸钾置于多功能流化床中,风量设置为15m3/h~25m3/h,进风温度设置为80℃~100℃,对物料进行加热预混7~15分钟,得到混合物料;预混完毕后,通过调节风量及进风温度,使得混合物料温度达到35℃~40℃,然后多功能流化床开始喷浆,喷浆速度设置为15rpm~20rpm,雾化压力为1.50bar~2.0bar,由于喷浆后物料加重,温度降低,随时调节风量保持物料充分跳跃,并随时调节进风温度使物料温度保持在35℃~40℃,喷浆15min~30min后关闭喷浆,完成制粒;再将多功能流化床的进风温度设置为100℃对物料进行干燥,调节风量保持物料充分跳跃,当物料的水分≤2.0%时,将进风温度降至25℃~45℃,使物料的温度降为25℃~45℃,最后出料关机。
4.根据权利要求2所述用于治疗胃病中药组合物的制备方法,其特征在于:所述步骤6中,将步骤5得到的干颗粒在振荡筛上选取14目~60目之间的颗粒完成整粒,然后将选取的干颗粒装入袋中完成灌装。
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