CN106343986B - A kind of ambulatory blood pressure non-contact monitoring device based on camera - Google Patents

A kind of ambulatory blood pressure non-contact monitoring device based on camera Download PDF

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CN106343986B
CN106343986B CN201610834471.1A CN201610834471A CN106343986B CN 106343986 B CN106343986 B CN 106343986B CN 201610834471 A CN201610834471 A CN 201610834471A CN 106343986 B CN106343986 B CN 106343986B
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blood pressure
module
time
real
heart rate
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CN106343986A (en
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孟濬
赵夕朦
许文媛
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Zhejiang University ZJU
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/02—Detecting, measuring or recording pulse, heart rate, blood pressure or blood flow; Combined pulse/heart-rate/blood pressure determination; Evaluating a cardiovascular condition not otherwise provided for, e.g. using combinations of techniques provided for in this group with electrocardiography or electroauscultation; Heart catheters for measuring blood pressure
    • A61B5/021—Measuring pressure in heart or blood vessels
    • A61B5/02108—Measuring pressure in heart or blood vessels from analysis of pulse wave characteristics
    • A61B5/02125—Measuring pressure in heart or blood vessels from analysis of pulse wave characteristics of pulse wave propagation time
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
    • A61B5/0062—Arrangements for scanning
    • A61B5/0064—Body surface scanning
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
    • A61B5/0077—Devices for viewing the surface of the body, e.g. camera, magnifying lens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/72—Signal processing specially adapted for physiological signals or for diagnostic purposes
    • A61B5/7235—Details of waveform analysis

Abstract

The invention discloses a kind of ambulatory blood pressure non-contact monitoring device based on camera, including data acquisition unit, model training unit, real-time blood pressure output unit.Data acquisition unit includes image capture module and blood pressure acquisition module；Model training unit includes skin area location tracking module, extraction module, functional relation fitting module.Real-time blood pressure output unit acquires the skin video with two or more distance labels of the user by image capture module in real time, the phase difference and heart rate obtained in real time according to extraction module, by in phase difference and the model of heart rate input training, real-time ambulatory blood pressure is obtained.Blood pressure obtaining means of the invention can carry out the acquisition of ambulatory blood pressure under the conditions of discontiguous to target, human body will not be caused uncomfortable because of long term monitoring or night monitoring.The present invention combines target following technology with the blood pressure obtaining means, and the real-time blood pressure that dynamic human body may be implemented continuously acquires.

Description

A kind of ambulatory blood pressure non-contact monitoring device based on camera
Technical field
The present invention relates to field of biological medicine, and in particular to a kind of non-contact monitoring of blood pressure dress based on camera It sets.
Background technique
Ambulatory blood pressure (Ambulatory blood pressure, ABP) can be used for the identification, diagnosis and the heart of hypertension The assessment of cerebrovascular complication risk is that hypertension manages indispensable Testing index.When clinic blood pressure can only provide current The blood pressure at quarter, blood pressure obtained will receive the influence of current environment, pressure value occur abnormal, lead to White coat hypertension With appearance phenomena such as false hypertension.And studies have shown that painstaking effort can be better anticipated in ambulatory blood pressure relative to clinic blood pressure The morbidity and mortality of pipe disease.Ambulatory blood pressure is more sensitive and accurate to the classification of risk of cardiovascular diseases, with hypertension There is more close relationship.
Although ambulatory blood pressure has great importance for the diagnosis and prognosis of high blood pressure disease, due to ambulatory blood pressure Monitor needs to contact human body and is just able to achieve blood pressure acquisition, is the certain limitation of ambulatory blood pressure monitoring bring.According to 2013 Year European Hypertension Guideline, the limitation of ambulatory blood pressure monitors are mainly included in the limitation of application aspect and effect aspect.? Application aspect, in such a way that ambulatory blood pressure monitors obtain ambulatory blood pressure, in duplicate measurements or night sleep In the case of can cause patient do not accommodate resistance psychology, cause patient refuse wear；The higher cost of ambulatory blood pressure monitor, is not suitable for The whole people are universal to be used.In terms of effect, the effect is unsatisfactory for blood pressure acquisition of the ambulatory blood pressure monitors to dynamic human body, compared to Patient is in dynamic, is more suitable for monitoring of blood pressure when patient at rest's state；When using ambulatory blood pressure monitors, if blood pressure is supervised The step of survey, is lack of standardization, and the reproducibility of data is not high.
Summary of the invention
In view of the above-mentioned deficiencies in the prior art, it is an object of the present invention to provide a kind of portable strong non-contact, non-invasion, In real time, the unconstrained ambulatory blood pressure monitoring device based on camera.
The purpose of the present invention is achieved through the following technical solutions: a kind of ambulatory blood pressure based on camera is non-contact Monitoring device, comprising: data acquisition unit, model training unit, real-time blood pressure output unit.Wherein:
The data acquisition unit includes image capture module and blood pressure acquisition module；Described image acquisition unit is for obtaining The video information of the human skin with two or more distance labels is taken, and passes it to model training unit；It is described Blood pressure acquisition module acquires a blood pressure every the Δ t time by electronic sphygmomanometer, obtains blood pressure sequence B P1~BPm, and by its Pass to model training unit.
The model training unit includes skin area location tracking module, extraction module, functional relation fitting module.
The mark point P that the skin area location tracking module passes through spacing distance d on purported skin1~Pn(n is label Point number, n >=2) each frame image of transmitted to data acquisition unit video carries out the positioning of each mark point and with each label The cutting of label skin area centered on point, is integrated into the video sequence V that each mark point corresponds to skin area1~Vn, point The video clip V of Δ t is divided between not being cut into time11~V1m,V21~V2m,…,Vn1~Vnm(m is time hop counts, m >=2), To correspond to each group blood pressure BP that electronic sphygmomanometer measures simultaneously1~BPm。
The extraction module be based on imaging type photoplethysmography (Imaging Photoplethysmographic, IPPG principle) extracts the pulse signal of marked region video clip, and seeks same distance mark point pair under the same Δ t period Answer the phase difference average value between pulse signalAnd the heart rate HR of the period.
The functional relation fitting module is initially set up based on blood pressure BP, pulse signal phase differenceWith heart rate HR three Between functional relationThen the phase difference average value transmitted according to extraction moduleHeart rate HR and The pressure value of electronic sphygmomanometer acquisition carries out Function Fitting, obtains the undetermined coefficient a and k of the functional relation, completes the user's Model training.
The real-time blood pressure output unit by image capture module acquire in real time the user with two or more The skin video of distance label, the phase difference and heart rate obtained in real time according to extraction module, by phase difference and heart rate input training Model in, obtain real-time ambulatory blood pressure.
Further, the same distance mark point is
Further, described to be based on imaging type photoplethysmography specifically: using visible light as light source, by blood The variation of the light of the caused human skin surface of liquid volume variation is recorded in the form of video, then people is obtained from video The pulse signal of body and relevant physiological parameter.
Further, heart rate acquiring method includes but is not limited to seek frequency spectrum of the pulse signal within the scope of a band frequency simultaneously Take the corresponding frequency of its peak value.
Further, phase difference acquiring method includes but is not limited to the difference for seeking two sections of pulse signal phase frequency peak values, further according to Its required heart rate carries out being scaled the time.
The beneficial effects of the present invention are:
(1) blood pressure obtaining means of the invention can carry out the acquisition of ambulatory blood pressure under the conditions of discontiguous to target, Human body will not be caused uncomfortable because of long term monitoring or night monitoring.
(2) present invention combines target following technology with the blood pressure obtaining means, and the real-time of dynamic human body may be implemented Blood pressure continuously acquires.
Detailed description of the invention
Fig. 1 is overall structure block diagram of the invention；
Fig. 2 is skin area location tracking module operation schematic diagram of the present invention；
Fig. 3 is same distance mark point combination diagram of the present invention；
Fig. 4 is the specific work steps schematic diagram of the embodiment of the present invention；
Fig. 5 is the Function Fitting figure of the embodiment of the present invention.
Specific embodiment
It is detailed below according to attached drawing in order to which the non-contact blood pressure monitoring device of the invention based on camera is described in more detail Describe the bright present invention in detail.
As shown in Figure 1, a kind of ambulatory blood pressure non-contact monitoring device based on camera, comprising: data acquisition unit, mould Type training unit, real-time blood pressure output unit.Wherein:
The data acquisition unit includes image capture module and blood pressure acquisition module；Described image acquisition unit is for obtaining The video information of the human skin with two or more distance labels is taken, and passes it to model training unit；It is described Blood pressure acquisition module acquires a blood pressure every the Δ t time by electronic sphygmomanometer, obtains blood pressure sequence B P1~BPm, and by its Pass to model training unit.
The model training unit includes skin area location tracking module, extraction module, functional relation fitting module.
The mark point P that the skin area location tracking module passes through spacing distance d on purported skin1~Pn(n is label Point number, n >=2) each frame image of transmitted to data acquisition unit video carries out the positioning of each mark point and with each label The cutting of label skin area centered on point, is integrated into the video sequence V that each mark point corresponds to skin area1~Vn, point The video clip V of Δ t is divided between not being cut into time11~V1m,V21~V2m,…,Vn1~Vnm(m is time hop counts, m >=2), To correspond to each group blood pressure BP that electronic sphygmomanometer measures simultaneously1~BPm, such as Fig. 2.
The extraction module be based on imaging type photoplethysmography (Imaging Photoplethysmographic, IPPG principle) extracts the pulse signal of marked region video clip, and seeks same distance mark point pair under the same Δ t period Answer the phase difference average value between pulse signalAnd the heart rate HR of the period.The same distance mark point isOr to meet other combinations apart from the same terms, such as Fig. 3.
The functional relation fitting module is initially set up based on blood pressure BP, pulse signal phase differenceWith heart rate HR three Between functional relationThen the phase difference average value transmitted according to extraction moduleHeart rate HR and The pressure value of electronic sphygmomanometer acquisition carries out Function Fitting, obtains the undetermined coefficient a and k of the functional relation, completes the user's Model training.
The derivation process of the functional relation is as follows: Pulse transit time (pulse wave transfer time, PWTT) meet relationship between blood pressure (blood pressure, BP)
BP=a+b × PWTT (1)
Wherein, the value of a and b and the vessel wall elasticity of human body are related, and same individual will not be occurred too in a short time Big change.Since the calculating of Pulse transit time is to make the peak value of the R wave of electrocardiogram (electrocardiogram, ECG) For the starting point of Pulse transit time measurement, the peak point of photoplethysmographic (Photoplethysmographic, PPG) Terminating point as measurement.Therefore, two fixing points P on human body1And P2Pulse transit time PWTT1, PWTT2Difference DELTA PWTT should meet relationship:
Δ PWTT=c × PWTT2 (2)
It is full by the difference of the available human blood-pressure of formula (1) formula (2) and the Pulse transit time between two fixing points Sufficient relationship:
BP=a+k × Δ PWTT (3)
Due to the pulse signal phase difference between two o'clockMeet between the difference Δ PWTT of Pulse transit time:
In formula, HR represents the heart rate value at individual current time, and the different parts on the same individual of synchronization are obtained Heart rate value it is identical.
It obtains formula (5) substitution formula (3) to meet relationship between blood pressure and the pulse signal phase difference of two fixed points:
In formula, undetermined coefficient a and k, heart rate HR and phase differenceFor unknown number.
The real-time blood pressure output unit by image capture module acquire in real time the user with two or more The skin video of distance label, the phase difference and heart rate obtained in real time according to extraction module, by phase difference and heart rate input training Model in, obtain real-time ambulatory blood pressure.
Δ t in the model training unit is mainly related to acquisition time needed for blood pressure acquisition module, and described real-time Δ t in blood pressure output unit is not constrained.
Wherein, between the image acquisition units and processing unit (i.e. model training unit), processing unit and output It can be attached partially or completely through wired or wireless way between unit (i.e. real-time blood pressure output unit), to guarantee data Effective transmission.It can all be connected according to actual needs using wired mode, all using wireless mode connection or part It is connected using wired mode connection, partially using wireless mode.
Specifically, the non-contact blood pressure monitoring device of the invention based on camera, which can be only one, has camera function Desktop computer perhaps a laptop or an intelligent movable with camera function with camera function are whole End.At this point, input unit of the camera of equipment as system, processing unit of the process kernel as system or is deposited display screen Output unit of the storage unit as system.Non-contact blood pressure monitoring device based on camera of the invention, which is also possible to have, to be taken the photograph As the combination of the desktop computer of function, laptop or mobile intelligent terminal, for example, the intelligent movable with camera function is whole End is used as image acquisition units, and laptop process kernel and display screen are respectively as processing unit and output unit；For another example As input unit and processing unit, mobile intelligent terminal display screen is single as output for desktop computer camera and process kernel Member, etc..
Embodiment
Below for carrying out ambulatory blood pressure monitoring by the system that camera and computer form with one, base is illustrated In the non-contact blood pressure monitoring device of camera, as shown in Figure 1, comprising: data acquisition unit, model training unit, real-time blood Press output unit.Wherein:
The data acquisition unit includes image capture module and blood pressure acquisition module；Described image acquisition unit is for obtaining The video information of the human skin with two or more distance labels is taken, and passes it to model training unit；It is described Blood pressure acquisition module acquires a blood pressure every the Δ t time by electronic sphygmomanometer, obtains blood pressure sequence B P1~BPm, and by its Pass to model training unit.
The model training unit includes skin area location tracking module, extraction module, functional relation fitting module.
The mark point P that the skin area location tracking module passes through spacing distance d on purported skin1~Pn(n is label Point number, n >=2) each frame image of transmitted to data acquisition unit video carries out the positioning of each mark point and with each label The cutting of label skin area centered on point, is integrated into the video sequence V that each mark point corresponds to skin area1~Vn, point The video clip V of Δ t is divided between not being cut into time11~V1m,V21~V2m,…,Vn1~Vnm(m is time hop counts, m >=2), To correspond to each group blood pressure BP that electronic sphygmomanometer measures simultaneously1~BPm。
The extraction module be based on imaging type photoplethysmography (Imaging Photoplethysmographic, IPPG principle) extracts the pulse signal of marked region video clip, and seeks same distance mark point pair under the same Δ t period Answer the phase difference average value between pulse signalAnd the heart rate HR of the period.The same distance mark point isOr to meet other combinations apart from the same terms, such as Fig. 3.
The functional relation fitting module is initially set up based on blood pressure BP, pulse signal phase differenceWith heart rate HR three Between functional relationThen the phase difference average value transmitted according to extraction moduleHeart rate HR and The pressure value of electronic sphygmomanometer acquisition carries out Function Fitting, obtains the undetermined coefficient a and k of the functional relation, completes the user's Model training.
The real-time blood pressure output unit by image capture module acquire in real time the user with two or more The skin video of distance label, the phase difference and heart rate obtained in real time according to extraction module, by phase difference and heart rate input training Model in, obtain real-time ambulatory blood pressure.
The present invention is based on the specific work steps of the ambulatory blood pressure non-contact monitoring device of camera is as follows:
(1) data acquire
Image capture module is directed toward the skin area for carrying out distance label in advance by user, with obtain two or two, band with The video information of the human skin of upper distance label, and pass it to model training unit；At the same time, user adopts blood pressure Collection module is connected to electronic sphygmomanometer and acquires a blood pressure every the Δ t time, obtains blood pressure sequence B P1~BPm, and transmitted Give model training unit.
(2) model training
Model training unit receives the video information that image capture module is transmitted and blood pressure acquisition module is transmitted Blood pressure sequence B P1~BPm；Skin area location tracking module in model training unit passes through spacing distance d on purported skin Mark point P1~PnEach frame image of (n is mark point number, n >=2) video transmitted to data acquisition unit carries out each mark The cutting for remembering the positioning of point and the label skin area centered on each mark point, is integrated into each mark point and corresponds to skin region The video sequence V in domain1~Vn, the video clip V of Δ t is divided between being cut into time respectively11~V1m,V21~V2m,…,Vn1~ Vnm(m is time hop counts, m >=2), to correspond to each group blood pressure BP that electronic sphygmomanometer measures simultaneously1~BPm；Model training list Extraction module in member is based on imaging type photoplethysmography (Imaging Photoplethysmographic, IPPG) Principle extract the pulse signal of marked region video clip, and seek same distance mark point under the same Δ t period and correspond to arteries and veins The phase difference average value fought between signalAnd the heart rate HR of the period.The same distance mark point isFunction Fitting module in model training unit initially sets up base In blood pressure BP, pulse signal phase differenceFunctional relation between heart rate HR threeThen root The phase difference average value transmitted according to extraction moduleHeart rate HR and the pressure value of electronic sphygmomanometer acquisition carry out Function Fitting, obtain The undetermined coefficient a and k for obtaining the functional relation, complete the model training of the user.
(3) blood pressure output in real time:
Real-time blood pressure output unit by image capture module acquire in real time the user with two or more distances The skin video of label, the phase difference and heart rate obtained in real time according to extraction module, by the mould of phase difference and heart rate input training In type, real-time ambulatory blood pressure is obtained.
Step schematic diagram in the above-described embodiments is as shown in figure 4, wherein Function Fitting figure is as shown in Figure 5.
To one skilled in the art it should be understood that various modifications can be carried out according to design requirement and other factors, Combination is combined certainly and is changed, as long as they all fall in appended claims and its equivalent scheme limited range.

Claims (5)

1. a kind of ambulatory blood pressure non-contact monitoring device based on camera characterized by comprising data acquisition unit, mould Type training unit, real-time blood pressure output unit；Wherein:
The data acquisition unit includes image capture module and blood pressure acquisition module；Described image acquisition unit is for obtaining band The video information of the human skin of two or more distance labels, and pass it to model training unit；The blood pressure Acquisition module acquires a blood pressure every the △ t time by electronic sphygmomanometer, obtains blood pressure sequence B P1~BPm, and transmitted Give model training unit；
The model training unit includes skin area location tracking module, extraction module, functional relation fitting module；
The mark point P that the skin area location tracking module passes through spacing distance d on purported skin1~Pn；N is mark point Number, n >=2；Each frame image of video transmitted to data acquisition unit carries out the positioning of each mark point and with each mark point The cutting of the label skin area at center, is integrated into the video sequence V that each mark point corresponds to skin area1~Vn, exist respectively The video clip V of △ t is divided between being cut on time11~V1m,V21~V2m,...,Vn1~Vnm；M is time hop counts, m >=2；With right The each group blood pressure BP that should be measured simultaneously in electronic sphygmomanometer1~BPm；
The extraction module extracts the pulse letter of marked region video clip based on the principle of imaging type photoplethysmography Number, and seek same distance mark point under the same △ t period and correspond to phase difference average value between pulse signalAnd the period Heart rate HR；
The functional relation fitting module is initially set up based on blood pressure BP, pulse signal phase differenceBetween heart rate HR three Functional relationThen the phase difference average value transmitted according to extraction moduleHeart rate HR and electronics blood It presses the pressure value of instrument acquisition to carry out Function Fitting, obtains the undetermined coefficient a and k of the functional relation, complete the model training of user；
The real-time blood pressure output unit by image capture module acquire in real time the user with two or more distances The skin video of label, the phase difference and heart rate obtained in real time according to extraction module, by the mould of phase difference and heart rate input training In type, real-time ambulatory blood pressure is obtained.
2. a kind of ambulatory blood pressure non-contact monitoring device based on camera according to claim 1, which is characterized in that institute Stating same distance mark point is
3. a kind of ambulatory blood pressure non-contact monitoring device based on camera according to claim 1, which is characterized in that institute It states based on imaging type photoplethysmography specifically:, will be caused by volumetric blood variation using visible light as light source The variation of the light of human skin surface is recorded in the form of video, then the pulse signal and correlation of human body are obtained from video Physiological parameter.
4. a kind of ambulatory blood pressure non-contact monitoring device based on camera according to claim 1, which is characterized in that the heart Rate acquiring method includes but is not limited to the frequency spectrum sought pulse signal within the scope of a band frequency and takes the corresponding frequency of its peak value.
5. a kind of ambulatory blood pressure non-contact monitoring device based on camera according to claim 1, which is characterized in that phase Potential difference acquiring method includes but is not limited to the difference for seeking two sections of pulse signal phase frequency peak values, is scaled further according to heart rate required by it Time.
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