CN106342826A - Fungicide composition - Google Patents
Fungicide composition Download PDFInfo
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- CN106342826A CN106342826A CN201610718278.1A CN201610718278A CN106342826A CN 106342826 A CN106342826 A CN 106342826A CN 201610718278 A CN201610718278 A CN 201610718278A CN 106342826 A CN106342826 A CN 106342826A
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- Prior art keywords
- ethirimol
- active component
- microbicide compositions
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- 0 *N1Sc2scccc2C1=* Chemical compound *N1Sc2scccc2C1=* 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/48—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with two nitrogen atoms as the only ring hetero atoms
- A01N43/54—1,3-Diazines; Hydrogenated 1,3-diazines
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/72—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms as ring hetero atoms
- A01N43/80—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms as ring hetero atoms five-membered rings with one nitrogen atom and either one oxygen atom or one sulfur atom in positions 1,2
Abstract
The invention provides a fungicide composition. The composition is prepared from two active components A and B; the active component A is a structure compound with a formula (I); the active component B is ethirimol or a derivative thereof; the weight ratio of the active component A to the active component B is 1 : (1 to 30). The invention further provides a preparation method and application of the composition. A test result shows that the synergistic effect of the fungicide composition provided by the invention is obvious; more importantly, the application amount is reduced, and the utilization cost is reduced. The fungicide composition provided by the invention can be used for effectively preventing and treating certain specific bacterium or fungus diseases of crops. By compounding fungicides with different acting mechanisms and acting manners, the fungicide composition has very good effects on the aspects of enlarging a fungicidal spectrum, delaying fungus and bacterium resistance, improving prevention and treatment effects and the like.
Description
Technical field
The invention belongs to agriculture plant protection field, more particularly to a kind of bactericidal composition with improvement performance, tool
Say it is to be related to a kind of bactericidal composition comprising BIT class and ethirimol and its derivant body.
Background technology
BIT class compound is a kind of new, wide-spectrum bactericide, is mainly used in preventing and treating and treats Cereal
The various bacteria such as crop, veterinary antibiotics, fungal disease.Its bactericidal action mechanism, the main destruction pathogenic bacteria nucleus that include are tied
Structure, so as to lose cardia and exhaustion is dead and the metabolism of interference pathogenic bacteria cell is so as to physiologic derangement, ultimately results in dead
Die two aspects.In disease early period of origination using can effective protection plant not infected by pathogen, disease takes the circumstances into consideration to increase after occurring
Dosage can substantially control spreading of pathogenic bacteria, thus reaching protection and the dual function rooted out.
Ethirimol (ethirimol) and its derivant bupirimate (bupirimate) belong to absorbability heterocyclic and kill
Microbial inoculum, is mainly used in preventing and treating the powdery mildew of the crops such as Fructus Mali pumilae, Fructus Fragariae Ananssae, Citrullus vulgariss, Fructus Cucumidis sativi, Fructus Vitis viniferae, greenhouse Flos Rosae Rugosae and Fructus Fragariae Ananssae.Its sterilization
Action character has an extremely strong killing effect to mycelium, conidium, receptive hypha etc., and can strongly suppress the formation of spore,
Block spore and infect source again, bactericidal effect is comprehensively thorough.For the crop having fallen ill, therapeutical effect well can be played,
The pathogenic bacteria in invaded plantses body can be rooted out, can substantially suppress the extension of pathogenic bacteria, no interactions resistance.
Actual pesticide experience have shown that, repeats and a kind of reactive compound of single-minded administration is preventing and treating harmful fungoid very
The fast selective of fungal bacterial strain will be led in the case of many, optionally dangerous for reducing refractory fungal bacterial strain, at present generally
Mixture using different activities compound prevents and treats harmful fungoid.By the reactive compound with the different mechanisms of action is entered
Row combination, delaying drug resistance can produce, reduces amount of application, reduce cost accounting.
Content of the invention
The purpose of the present invention is for antibacterial resistance and pedo relict problem in actual applications, filters out difference and kills
The antibacterial of bacterium principle is compounded, and obtains a kind of new microbicide compositions, to improve bactericidal agent for preventing and treating effect, delaying drug resistance
Produce, reduce amount of application, reduce cost accounting.
It is a further object to provide comprise two kinds of effective ingredient a and b bactericidal composition preparation method and
Agriculture field prevents and treats the application of corps diseases.
The purpose of the present invention can be reached by following measures:
A kind of microbicide compositions with potentiation, said composition comprises two kinds of active components of a and b, wherein activity
Component a is to have the structural compounds of formula (), and active component b is ethirimol and its derivant.
In formula (), r is selected from h or c1～c8Alkyl.
C in the present invention1～c8Alkyl refers to the straight or branched alkyl containing 1 to 8 carbon atom, and it includes c1Alkyl
(as methyl), c2Alkyl (as ethyl), c3Alkyl (as n-pro-pyl, isopropyl), c4Alkyl (as normal-butyl, isobutyl group, the tert-butyl group,
Sec-butyl), c5Alkyl (as n-pentyl etc.), c6Alkyl, c7Alkyl, c8Alkyl.It includes but is not limited to c1～c6Alkyl, c1～c5
Alkyl, c1～c4Alkyl etc..
In a kind of preferred version, r is selected from h or c1～c4Alkyl.
In a kind of preferred scheme, r is selected from h ,-ch3Or-c4h9.
In formula (), when r is for h, a is BIT (abbreviation bit in description).
In formula (), when r is-ch3When, a is 2- methyl isophthalic acid, and 2- benzisothiazole-3-ketone is (in description referred to as
mbit).
In formula (), when r is-c4h9When, a is 2- butyl-BIT, and " butyl " in this formula is excellent
Select normal-butyl (abbreviation bbit in description).
In active component b ethirimol derivant can using the various derivants of ethirimol in prior art, preferably include but
It is not limited to bupirimate.
Inventor is found by experiment that, the compositionss of the present invention are for preventing and treating crops antibacterial or fungal disease preventing and treating
Potentiation substantially it is often more important that amount of application reduces, reduces use cost.Compound structure type containing component a and component b is not
With mechanism of action is different, and both are compounding can to expand fungicidal spectrum, and can delay the product of pathogen resistance to a certain extent
Raw no interactions resistance and development speed, and component a and component b between.
The weight between two components in microbicide compositions of the present invention is than for 1:1～30.For making the drug effect between two components
Potentiation is more notable, and the weight ratio between weight two component of component a and component b can be optimized to 1:5～25 further.
In a kind of preferred scheme, the weight ratio between a and b two component can arbitrarily enter in the range of following proportionings
Row adjustment: 1:1,1:2,1:3,1:4,1:5,1:6,1:7,1:8,1:9,1:10,1:11,1:12,1:13,1:14,1:15,1:
16th, 1:17,1:18,1:19,1:20,1:21,1:22,1:23,1:24,1:25,1:26,1:27,1:28,1:29,1:30, also may be used
Selected with the range of forming in two proportionings of any of the above, these ratios can be understood as weight ratio it is also possible to wrap
Include mol ratio.
The compositionss of the present invention can make, by active component and insecticides adjuvant or adjuvant, the dosage form allowing on pesticide.Enter one
Step, said composition is made up of fair on pesticide the active component of 2～80% weight portions and the insecticides adjuvant of 98～20% weight portions
The dosage form permitted.
The invention provides comprising the bactericidal composition of component a and component b in terms of agriculture field preventing and treating corps diseases
Purposes, the particularly purposes in terms of preventing and treating the funguses of some crops or antibacterial.
Above-mentioned composition specifically can comprise insecticides adjuvant or adjuvant, for example carrier, solvent, dispersant, wetting agent, gluing
One or more of agent, thickening agent, binding agent, surfactant or fertilizer etc..Can mix conventional during applying
Auxiliary agent.
Suitable auxiliary agent or adjuvant can be solid or liquid, the material that they are commonly used during being typically formulation,
The mineral of for example natural or regeneration, solvent, dispersant, wetting agent, adhesive, thickening agent, binding agent.
The application process of the present composition includes the compositionss of the present invention being used for the aerial partss of plant growing, especially
It is leaf portion or blade face.Can select to soak seed or be applied in controlling object surface.The frequency applied and amount of application depend on pathogen
Biology and weather conditions of existence.Can be by the growth place of plant, such as rice field, soaked with the liquid preparation of compositionss, or
Compositionss are applied in soil person in solid form, and such as in granular form (soil application), compositionss can be by soil through planting
Thing root enters in plant body (systemic action).
The compositionss of the present invention can be prepared into acceptable various dosage forms, including but not limited to cream, suspension on pesticide
Agent, wettable powder, water dispersible granules, powder, granule, water preparation, aqueous emulsion, microemulsion, poison bait, mother solution, female powder etc., in one kind
In preferred version, the dosage form of the present invention adopts wettable powder, suspending agent, water dispersible granules, aqueous emulsion or microemulsion.According to this
The property of a little compositionss and apply compositionss purpose to be reached and ambient conditions, can select compositionss to spray,
Atomizing, dust, broadcast sowing or sprinkle the method poured or the like and apply.
The compositionss of the present invention can be prepared into various dosage forms by available known method, can by effective ingredient with help
Agent, such as solvent, solid carrier, can uniformly mix together with surfactant when needing, grind, the agent required for being prepared into
Type.
Above-mentioned solvent is selected from aromatic hydrocarbon, preferably contains 8-12 carbon atom, such as xylene mixture or substituted benzene, phthalein
Esters of gallic acid, such as Dibutyl phthalate or phthalandione two octanoic acid, fat hydrocarbon, such as thiacyclohexane or paraffin, alcohol and ethylene glycol and their ether
And ester, such as ethanol, ethylene glycol, ethylene glycol monomethyl；Ketone, such as cyclohexanone, highly polar solvent, such as n- methyl -2- pyrrolidine
Ketone, dimethyl sulfoxide or dimethylformamide, and vegetable oil or vegetable oil, such as soybean oil.
Above-mentioned solid carrier, such as powder and the typically natural mineral fillers dispersibling agent, such as Talcum, kaolinite
Soil, montmorillonite or active hargil.In order to manage the physical property of compositionss it is also possible to add polymolecularity silicic acid or polymolecularity
Adsorpting polymerization thing carrier, such as granulated adsorptive carriers or non-adsorbed carrier, suitable granulated adsorptive carriers are porous types, such as floating
Stone, Bentonite or bentonite；Suitable non-adsorbed carrier such as calcite or sand.Further, it is possible to use substantial amounts of inorganic in nature or have
The prefabricated material granulating of machine property is as carrier, particularly dolomite.
According to the chemical property of the effective ingredient in the compositionss of the present invention, suitable surfactant is sulfomethylated lignin
Acid, LOMAR PWA EINECS 246-676-2, phenolsulfonic acid, alkali salt or amine salt, alkylaryl sulfonatess, alkyl sulfate, alkylsulfonate, fat
Alcohol sulfate, fatty acid and sulphated fatty alcohol glycol ether, the also condensation substance of sulfonated naphthalene and naphthalene derivativeses and formaldehyde, naphthalene or
LOMAR PWA EINECS 246-676-2 and the condensation substance of phenol and formaldehyde, NONIN HS 240, ethoxylated isooctyl-phenol, octyl phenol, nonyl phenol,
Alkylaryl polyglycol ether, tributyl benzene polyglycol ether, three stearyl phenyl polyglycol ethers, alkyl aryl polyether alcohol,
Ethoxylated castor oil, polyoxyethylene alkyl ether, ethylene oxide condensation substance, ethoxylation polyoxypropylene, Laurel acid polyethylene glycol
Ether acetal, sorbitol ester, lignin sulfite waste liquor and methylcellulose.
When preparing liquid or solid dosage formss, first active component a can be dissolved in some specific alkaline matters, form benzene
And isothiazoline slaine, suitable alkaline matter includes: alkali carbonate, alkali metal hydroxide are (as sodium hydroxide, hydrogen
Potassium oxide), alkali metal alkoxyl carbonate, alkali metal alcoholates or Bis(methoxy)magnesium.
In the compositionss of the present invention, two kinds of effective ingredient show as synergistic effect, and the activity of said composition is than using individualized
The expected summation of activity of compound, and the individually activity of single compound is more notable.Synergistic effect shows as allowing amount of application
Reduce, broader antifungal controls spectrum, instant effect, more longlasting prevention effect, pass through only once or minority is applied more several times
Good controls plant pest funguses and broadens the possible administration interval time.These characteristics are that plant epiphyte controls practice
During especially need.
The microbicide compositions of the present invention can be applicable to agriculture field preventing and treating corps diseases aspect, crop disease here
Evil particularly sigatoka, wheat rust, target, wildfire, rice sheath blight disease or tomato bacterial angle
Pinta etc..But the disease that the present composition can be applied is not limited to aforementioned several, the targeted concrete disease of the present invention
Disease includes but is not limited to wheat diseases (such as: wheat scab, wheat powdery mildew, wheat rust etc.), rice disease (such as: Oryza sativa L.
Banded sclerotial blight, rice green smut, rice blast, paddy bacterial streak etc.), maize diseases (such as: smut of maize, Semen Maydiss are big
Pinta, corn southern leaf blight), cucumber disease (such as: cucumber downy mildew, powdery mildew of cucumber, cucumber anthracnose, Fructus Cucumidis sativi bacillary angle speckle
Disease etc.), tomato disease (such as: anthracnose of tomato, graw mold of tomato, tomato bacterial angular leaf spot etc.), grape disease (such as: Fructus Vitis viniferae
Downy mildew, grape grey mould, uncinula necator), apple disease (as ring rot of apple, apple anthracnose etc.), citrus disease (Citrus chachiensis Hort.
Fructus Citri tangerinae Peptic Ulcerss, Citrus scab simultaneously, citrus anthracnose), tobacco diseases (wildfire) etc..
The other features showing of the bactericidal composition of the present invention are mainly shown as: 1, the compositionss mixture tool of the present invention
There is obvious potentiation；2nd, because two single dose chemical constitutions of this compositions are widely different, the mechanism of action is entirely different, no
There is cross resistance, two single doses can be delayed to be used alone produced resistance problem；3rd, the compositionss of the present invention to crop safety,
Preventive effect is good.Tests prove that, microbicide compositions stable chemical nature of the present invention, potentiation is notable, controlling object is shown bright
Aobvious potentiation and complementary action.
Specific embodiment
In order that the objects, technical solutions and advantages of the present invention become more apparent, with reference to embodiments, to the present invention
It is further elaborated.It should be appreciated that specific embodiment described herein, only in order to explain the present invention, is not used to limit
Determine the present invention, all any modification, equivalent and improvement made within the spirit and principles in the present invention etc., should be included in
Within protection scope of the present invention.
In all formula of following examples, percentage ratio is all weight percentage.The processing work of the various preparation of the present composition
Skill is prior art, can be varied from according to different situations.
First, dosage form preparation embodiment
(1) processing of water dispersible granules and embodiment
Mix homogeneously, active component activity packet a and active component b through gas in the ratio of formula with auxiliary agent and filler
Stream is ground into wettable powder, adds a certain amount of water mixing extruder grain, water dispersible granules is obtained and produces after drying screening
Product.
(1) active component a (bit) and active component ethirimol and its derivant prepare water dispersible granules
Embodiment 1:10%bit bupirimate water dispersible granules (1:1)
Bit 5%, bupirimate 5%, sodium lignin sulfonate 8%, potassium sulfate 6%, methylcellulose 6%, Linesless charcoal
Black 5%, precipitated calcium carbonate complements to 100%.
Embodiment 2:22%bit ethirimol water dispersible granules (1:10)
Bit 2%, ethirimol 20%, methyl naphthalene sulfonate formaldehyde condensate 6%, naphthalene sulfonic acid potassium 8%, ammonium alkyl sulfate
6%, kieselguhr complements to 100%.
(2) active component a (mbit) and active component ethirimol and its derivant prepare water dispersible granules
Embodiment 3:10%mbit bupirimate water dispersible granules
Mbit 5%, bupirimate 5%, remaining component is prepared according to the method for embodiment 1.
Embodiment 4:22%mbit ethirimol water dispersible granules
Mbit 2%, ethirimol 20%, remaining component is prepared according to the method for embodiment 2.
(3) active component a (bbit) and active component ethirimol and its derivant prepare water dispersible granules
Embodiment 5:10%bbit bupirimate water dispersible granules
Bbit 5%, bupirimate 5%, remaining component is prepared according to the method for embodiment 1.
Embodiment 6:22%bbit ethirimol water dispersible granules
Bbit 2%, ethirimol 20%, remaining component is prepared according to the method for embodiment 2.
(2) processing of suspending agent and embodiment
By active component activity packet a and active component b, each component is by joining with dispersant, wetting agent, thickening agent and water etc.
The ratio mix homogeneously of side, after sand milling and/or high speed shear, obtains semi-finished product, adds the filtration of water mix homogeneously and be after analysis
Obtain finished product.
(1) active component a (bit) and active component ethirimol and its derivant prepare suspending agent
Embodiment 7:10.5%bit ethirimol suspending agent (1:20)
Bit 0.5%, ethirimol 10%, kieselguhr 5%, sodium sulfonate 4%, xanthan gum 4%, toluene 6%, ethylene oxide contracts
Compound 8%, water complements to 100%.
Embodiment 8:52%bit bupirimate suspending agent (1:25)
Bit 2%, bupirimate 50%, calcite 8%, ethylene glycol 4%, lignin sulfonic acid potassium 8%, methyl naphthalene sulphur
Sour sodium formaldehyde condensation substance 5%, water complements to 100%.
(2) active component a (mbit) and active component ethirimol and its derivant prepare suspending agent
Embodiment 9:10.5%mbit ethirimol suspending agent
Mbit 0.5%, ethirimol 10%, remaining component is prepared according to the method for embodiment 7.
Embodiment 10:52%mbit bupirimate suspending agent
Mbit 2%, bupirimate 50%, remaining component is prepared according to the method for embodiment 8.
(3) active component a (bbit) and active component ethirimol and its derivant prepare suspending agent
Embodiment 11:10.5%bbit ethirimol suspending agent
Bbit 0.5%, ethirimol 10%, remaining component is prepared according to the method for embodiment 7.
Embodiment 12:52%bbit bupirimate suspending agent
Bbit 2%, bupirimate 50%, remaining component is prepared according to the method for embodiment 8.
(3) processing of wettable powder and embodiment
Active component a and b active component and various auxiliary agents and filler etc. are sufficiently mixed in proportion, through ultrafine crusher powder
Wettable powder is obtained after broken.
(1) active component a (bit) and ethirimol and its derivant prepare wettable powder
Embodiment 13:18%bit ethirimol wettable powder (1:5)
Bit 3%, ethirimol 15%, potassium sulfonate 4%, alkylaryl sulfonatess 5%, white carbon 5%, precipitated calcium carbonate is mended
Enough to 100%.
Embodiment 14:32%bit bupirimate wettable powder (1:15)
Bit 2%, bupirimate 30%, pull open powder 6%, aliphatic alcohol sulfate 4%, bentonite 4%, kieselguhr is mended
Enough to 100%.
Embodiment 15:46.5%bit ethirimol wettable powder (1:30)
Bit 1.5%, ethirimol 45%, lignin sulfonic acid potassium 8%, methyl naphthalene sulfonate formaldehyde condensate 10%, xanthan
Glue 6%, Kaolin complements to 100%.
(2) active component a (mbit) and ethirimol and its derivant prepare wettable powder
Embodiment 16:18%mbit ethirimol wettable powder
Mbit 3%, ethirimol 15%, remaining component is prepared according to the method for embodiment 13.
Embodiment 17:32%mbit bupirimate wettable powder
Mbit 2%, bupirimate 30%, remaining component is prepared according to the method for embodiment 14.
Embodiment 18:46.5%mbit ethirimol wettable powder
Mbit 1.5%, ethirimol 45%, remaining component is prepared according to the method for embodiment 15.
(3) active component a (bbit) and ethirimol and its derivant prepare wettable powder
Embodiment 19:18%bbit ethirimol wettable powder
Bbit 3%, ethirimol 15%, remaining component is prepared according to the method for embodiment 13.
Embodiment 20:32%bbit bupirimate wettable powder
Bbit 2%, bupirimate 30%, remaining component is prepared according to the method for embodiment 14.
Embodiment 21:46.5%bbit ethirimol wettable powder
Bbit 1.5%, ethirimol 45%, remaining component is prepared according to the method for embodiment 15.
2nd, drug effect checking test
(1) Assays Example
Investigate the incidence of whole strain blade according to test grade scale, calculate disease index and prevention effect.
Prevention effect is converted into niqueMin (y), medicinal liquid is done height (μ g/ml) and is converted into logarithm value (x), with least square
Method calculates Konzentration c50 in virulence equation and suppression, calculates toxicity index level co-toxicity coefficient (ctc) of medicament according to the abundant method of Sun Yun.
Actual measurement toxicity index (ati)=(standard agent ec50/ reagent agent ec50) * 100
Percentage composition+b medicament toxicity index * the mixture of a in theoretical toxicity index (tti)=a medicament toxicity index * mixture
The percentage composition of middle b
Co-toxicity coefficient (ctc)=[mixture actual measurement toxicity index (ati)/mixture theoretical toxicity index (tti)] * 100
Ctc≤80, compositionss show as antagonism, 80 ＜ ctc ＜ 120, and compositionss show as summation action, ctc >=
120, compositionss show as potentiation.
1st, bit and ethirimol compound and sigatoka toxicity test are tested
Table 1.bit is compounded to sigatoka toxicity test interpretation of result with ethirimol
| Medicament title | ec50(μg/ml) | ati | tti | Co-toxicity coefficient (ctc) |
| bit | 21.57 | 100.00 | \ | \ |
| Ethirimol | 14.92 | 144.57 | \ | \ |
| Bit: ethirimol=1:1 | 14.15 | 152.39 | 122.29 | 124.62 |
| Bit: ethirimol=1:5 | 11.86 | 181.82 | 137.14 | 132.58 |
| Bit: ethirimol=1:10 | 10.57 | 204.16 | 140.52 | 145.29 |
| Bit: ethirimol=1:15 | 9.59 | 224.91 | 141.78 | 158.63 |
| Bit: ethirimol=1:20 | 10.28 | 209.77 | 142.45 | 147.26 |
| Bit: ethirimol=1:25 | 11.13 | 193.83 | 142.86 | 135.68 |
| Bit: ethirimol=1:30 | 12.01 | 179.59 | 143.13 | 125.47 |
Result (table 1) shows, bit and ethirimol compound the prevention effect to sigatoka and significantly improve, and the two is described
Compounding have significant potentiation to sigatoka preventing and treating.Experiment finds, bit is not wanted in the present invention with the proportioning of ethirimol
When in the range of asking, combination thing is difficult to synergistic function to sigatoka.
2nd, bit and bupirimate compound and wheat rust toxicity test are tested
Table 2.bit is compounded to wheat rust toxicity test interpretation of result with bupirimate
Result (table 2) shows, bit and bupirimate compound the prevention effect to wheat rust and significantly improve, explanation
The two compounding wheat rust is prevented and treated has significant potentiation.Experiment finds, the proportioning of bit and bupirimate is not at this
When in the required scope of invention, combination thing is difficult to synergistic function to wheat rust.
3rd, mbit and ethirimol are tested to target toxicity test
Table 3.mbit is compounded to target toxicity test interpretation of result with ethirimol
| Medicament title | ec50(μg/ml) | ati | tti | Co-toxicity coefficient (ctc) |
| mbit | 24.26 | 100.00 | \ | \ |
| Ethirimol | 14.94 | 162.38 | \ | \ |
| Mbit: ethirimol=1:1 | 14.86 | 163.29 | 131.19 | 124.47 |
| Mbit: ethirimol=1:5 | 12.64 | 191.95 | 151.98 | 126.30 |
| Mbit: ethirimol=1:10 | 11.44 | 212.01 | 156.71 | 135.29 |
| Mbit: ethirimol=1:15 | 10.42 | 232.90 | 158.48 | 146.96 |
| Mbit: ethirimol=1:20 | 11.10 | 218.57 | 159.41 | 137.11 |
| Mbit: ethirimol=1:25 | 11.90 | 203.93 | 159.98 | 127.47 |
| Mbit: ethirimol=1:30 | 12.37 | 196.16 | 160.37 | 122.32 |
Result (table 3) shows, mbit and ethirimol compound the prevention effect to target and significantly improve, and illustrate two
Person compounds has significant potentiation to target preventing and treating.Experiment finds, the proportioning of mbit and ethirimol is not at this
When in bright required scope, combination thing is difficult to synergistic function to target.
4th, mbit and bupirimate compound and wildfire toxicity test are tested
Table 4.mbit is compounded to wildfire toxicity test interpretation of result with bupirimate
Result (table 4) shows, mbit and bupirimate compound the prevention effect to wildfire and significantly improve, and say
The two compounding wildfire is prevented and treated bright has significant potentiation.Experiment finds, the proportioning of mbit and bupirimate
When not in scope of the presently claimed invention, combination thing is difficult to synergistic function to wildfire.
5th, bbit and ethirimol compound and rice sheath blight disease toxicity test are tested
Table 5.bbit is compounded to rice sheath blight disease toxicity test interpretation of result with ethirimol
| Medicament title | ec50(μg/ml) | ati | tti | Co-toxicity coefficient (ctc) |
| bbit | 16.32 | 100.00 | \ | \ |
| Ethirimol | 9.58 | 170.35 | \ | \ |
| Bbit: ethirimol=1:1 | 9.48 | 172.16 | 135.18 | 127.36 |
| Bbit: ethirimol=1:5 | 7.43 | 219.65 | 158.63 | 138.47 |
| Bbit: ethirimol=1:10 | 6.78 | 240.88 | 163.95 | 146.92 |
| Bbit: ethirimol=1:15 | 6.22 | 262.26 | 165.95 | 158.03 |
| Bbit: ethirimol=1:20 | 6.64 | 245.92 | 167.00 | 147.26 |
| Bbit: ethirimol=1:25 | 6.95 | 234.72 | 167.64 | 140.01 |
| Bbit: ethirimol=1:30 | 7.55 | 216.20 | 168.08 | 128.63 |
Result (table 5) shows, bbit and ethirimol compound the prevention effect to rice sheath blight disease and significantly improve, and the two is described
Compounding have significant potentiation to rice sheath blight disease controlling.Experiment finds, the proportioning of bbit and ethirimol is not in institute of the present invention
When in the range of requirement, combination thing is difficult to synergistic function to rice sheath blight disease.
6th, bbit and bupirimate compound and tomato bacterial angular leaf spot toxicity test are tested
Table 6.bbit is compounded to tomato bacterial angular leaf spot toxicity test interpretation of result with bupirimate
Result (table 6) shows, bbit and bupirimate compound notable to the prevention effect of tomato bacterial angular leaf spot
Improve, illustrate that the two compounding tomato bacterial angular leaf spot is prevented and treated has significant potentiation.Experiment discovery, bbit and ethirimol
When the proportioning of sulphonic acid ester is not in scope of the presently claimed invention, combination thing is difficult to tomato bacterial angular leaf spot to be had
Synergistic function.
(2) field efficacy checking test
Test method: at the initial stage of a disease, carry out immediately spraying for the first time, carry out second dispenser after 7 days, each processes 4
Individual cell, each cell 20 square meter.11 days investigation statisticses incidences before the medicine and after second medicine, 5 points of each cell is random
Sampling, 5 plants of crops of every investigation, the lesion area investigating every blade in whole strain accounts for the percentage rate of blade area and is classified, and calculates
Disease index and prevention effect.
Expected preventive effect (%)=x+y-xy/100 (wherein, x, y are single dose preventive effect)
Grade scale:
0 grade: disease-free spot；
1 grade: leaf spot lesion is less than 5, length is less than 1cm；
3 grades: leaf spot lesion 6-10, part scab length is more than 1cm；
5 grades: leaf spot lesion 11-25, part scab is linked to be piece, and lesion area accounts for the 10-25% of leaf area；
7 grades: leaf spot lesion more than 26, scab is linked to be piece, and lesion area accounts for the 26-50% of leaf area；
9 grades: scab is linked to be piece, more than 50% or full leaf that lesion area accounts for leaf area are withered.
1st, bit and ethirimol and its derivant compound field efficacy experiment
Table 7bit and ethirimol and its derivant mixture are to wheat powdery mildew prevention effect
Measurement result (table 7) shows, the preventive effect that bit matches wheat powdery mildew with ethirimol and its derivant significantly improves,
Illustrating the two to compound to wheat powdery mildew has significant potentiation.
2nd, mbit and ethirimol and its derivant compound field efficacy experiment
Table 8mbit and ethirimol and its derivant mixture are to cucumber downy mildew prevention effect
Measurement result (table 8) shows, mbit is substantially carried to the preventive effect of cucumber downy mildew with ethirimol and its derivant mixture
Height, illustrating the two to compound to cucumber downy mildew has significant potentiation.
3rd, bbit and ethirimol and its derivant compound field efficacy experiment
Table 9bbit and ethirimol and its derivant mixture are to apple anthracnose prevention effect
Measurement result (table 9) shows, bbit is substantially carried to the preventive effect of apple anthracnose with ethirimol and its derivant mixture
Height, illustrating the two to compound to apple anthracnose has significant potentiation.
Claims (10)
1. a kind of microbicide compositions are it is characterised in that described compositionss comprise two kinds of active components of a and b, wherein activearm
Point a is the structural compounds with formula (), and active component b is ethirimol or derivatives thereof, and the ratio of the weight between two components is for 1:
1～30
In formula (), r is selected from h or c1～c8Alkyl.
2. microbicide compositions according to claim 1 are it is characterised in that in formula (), r is selected from h or c1～c4Alkyl.
3. microbicide compositions according to claim 1 are it is characterised in that in formula (), r is selected from h ,-ch3Or-c4h9, right
Active component a answered is respectively 1,2- benzisothiazole-3-ketone, 2- methyl isophthalic acid, 2- benzisothiazole-3-ketone or 2- fourth
Base -1,2- benzisothiazole-3-ketone.
4. microbicide compositions according to claim 1 are it is characterised in that in active component b, ethirimol derivant is selected from
Bupirimate.
5. microbicide compositions according to claim 1 are it is characterised in that the weight ratio of active component a and active component b
For 1:5～25.
6. the microbicide compositions according to any one in claim 1,2,3,4 or 5 it is characterised in that said composition by
Active component and insecticides adjuvant or adjuvant make the dosage form allowing on pesticide.
7. microbicide compositions according to claim 6 are it is characterised in that described dosage form is wettable powder, suspending agent
Or water dispersible granules.
8. the microbicide compositions according to claim 6 or 7 are it is characterised in that described insecticides adjuvant or adjuvant are selected from and carry
One or more of body, solvent, dispersant, wetting agent, adhesive, thickening agent, binding agent, surfactant or fertilizer.
9. in claim 1,2,3,4 or 5, the microbicide compositions described in any one prevent and treat corps diseases in agriculture field
The purposes of aspect.
10. purposes according to claim 9 is it is characterised in that described corps diseases are selected from sigatoka, Semen Tritici aestivi rust
Disease, target, wildfire, rice sheath blight disease or tomato bacterial angular leaf spot.
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610718278.1A CN106342826A (en) | 2016-08-24 | 2016-08-24 | Fungicide composition |
| PCT/CN2017/093018 WO2018036302A1 (en) | 2016-08-24 | 2017-07-14 | Fungicidal composition |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610718278.1A CN106342826A (en) | 2016-08-24 | 2016-08-24 | Fungicide composition |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN106342826A true CN106342826A (en) | 2017-01-25 |
Family
ID=57844878
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201610718278.1A Withdrawn CN106342826A (en) | 2016-08-24 | 2016-08-24 | Fungicide composition |
Country Status (2)
| Country | Link |
|---|---|
| CN (1) | CN106342826A (en) |
| WO (1) | WO2018036302A1 (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2018036302A1 (en) * | 2016-08-24 | 2018-03-01 | 江苏辉丰农化股份有限公司 | Fungicidal composition |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101669486A (en) * | 2009-10-16 | 2010-03-17 | 深圳诺普信农化股份有限公司 | Benzolkresoxim-methyl containing bactericide composition |
| CN101984809A (en) * | 2010-07-22 | 2011-03-16 | 福建诺德生物科技有限责任公司 | Oil suspension preparation using resin-based vegetable oil as carrier and preparation method thereof |
| CN102172240A (en) * | 2011-03-01 | 2011-09-07 | 陕西西大华特科技实业有限公司 | Bactericidal composition containing benziothiazolinone and methoxyl acrylic ester type bactericides |
| CN103704234A (en) * | 2014-01-07 | 2014-04-09 | 中国农业科学院植物保护研究所 | Composite for preventing and controlling agricultural bacterial disease |
| CN105685061A (en) * | 2016-02-29 | 2016-06-22 | 陕西西大华特科技实业有限公司 | Application of benziothiazolinone in preventing and treating potato seed-borne diseases and promoting rooting and germination |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU766476B2 (en) * | 1998-06-10 | 2003-10-16 | Bayer Intellectual Property Gmbh | Agents for combating plant pests |
| AU752045B2 (en) * | 1998-06-17 | 2002-09-05 | Bayer Aktiengesellschaft | Agents for controlling plant pests |
| CN106342826A (en) * | 2016-08-24 | 2017-01-25 | 江苏辉丰农化股份有限公司 | Fungicide composition |
-
2016
- 2016-08-24 CN CN201610718278.1A patent/CN106342826A/en not_active Withdrawn
-
2017
- 2017-07-14 WO PCT/CN2017/093018 patent/WO2018036302A1/en active Application Filing
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101669486A (en) * | 2009-10-16 | 2010-03-17 | 深圳诺普信农化股份有限公司 | Benzolkresoxim-methyl containing bactericide composition |
| CN101984809A (en) * | 2010-07-22 | 2011-03-16 | 福建诺德生物科技有限责任公司 | Oil suspension preparation using resin-based vegetable oil as carrier and preparation method thereof |
| CN102172240A (en) * | 2011-03-01 | 2011-09-07 | 陕西西大华特科技实业有限公司 | Bactericidal composition containing benziothiazolinone and methoxyl acrylic ester type bactericides |
| CN103704234A (en) * | 2014-01-07 | 2014-04-09 | 中国农业科学院植物保护研究所 | Composite for preventing and controlling agricultural bacterial disease |
| CN105685061A (en) * | 2016-02-29 | 2016-06-22 | 陕西西大华特科技实业有限公司 | Application of benziothiazolinone in preventing and treating potato seed-borne diseases and promoting rooting and germination |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2018036302A1 (en) * | 2016-08-24 | 2018-03-01 | 江苏辉丰农化股份有限公司 | Fungicidal composition |
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| Publication number | Publication date |
|---|---|
| WO2018036302A1 (en) | 2018-03-01 |
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