CN106336437A - Method for preparing fructose from glucose - Google Patents
Method for preparing fructose from glucose Download PDFInfo
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- CN106336437A CN106336437A CN201610681628.1A CN201610681628A CN106336437A CN 106336437 A CN106336437 A CN 106336437A CN 201610681628 A CN201610681628 A CN 201610681628A CN 106336437 A CN106336437 A CN 106336437A
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- fructose
- glucose
- acid
- salt
- consumption
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- RFSUNEUAIZKAJO-ARQDHWQXSA-N Fructose Chemical compound OC[C@H]1O[C@](O)(CO)[C@@H](O)[C@@H]1O RFSUNEUAIZKAJO-ARQDHWQXSA-N 0.000 title claims abstract description 50
- 229930091371 Fructose Natural products 0.000 title claims abstract description 50
- 239000005715 Fructose Substances 0.000 title claims abstract description 50
- 238000000034 method Methods 0.000 title claims abstract description 45
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 title claims abstract description 42
- 239000008103 glucose Substances 0.000 title claims abstract description 34
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 claims abstract description 39
- 238000006243 chemical reaction Methods 0.000 claims abstract description 22
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims abstract description 20
- 239000003377 acid catalyst Substances 0.000 claims abstract description 12
- 159000000013 aluminium salts Chemical class 0.000 claims abstract description 9
- 229910000329 aluminium sulfate Inorganic materials 0.000 claims abstract description 9
- 229910052799 carbon Inorganic materials 0.000 claims abstract description 9
- 238000006317 isomerization reaction Methods 0.000 claims abstract description 9
- 150000003657 tungsten Chemical class 0.000 claims abstract description 6
- IYDGMDWEHDFVQI-UHFFFAOYSA-N phosphoric acid;trioxotungsten Chemical compound O=[W](=O)=O.O=[W](=O)=O.O=[W](=O)=O.O=[W](=O)=O.O=[W](=O)=O.O=[W](=O)=O.O=[W](=O)=O.O=[W](=O)=O.O=[W](=O)=O.O=[W](=O)=O.O=[W](=O)=O.O=[W](=O)=O.OP(O)(O)=O IYDGMDWEHDFVQI-UHFFFAOYSA-N 0.000 claims abstract description 4
- CGFYHILWFSGVJS-UHFFFAOYSA-N silicic acid;trioxotungsten Chemical compound O[Si](O)(O)O.O=[W]1(=O)O[W](=O)(=O)O[W](=O)(=O)O1.O=[W]1(=O)O[W](=O)(=O)O[W](=O)(=O)O1.O=[W]1(=O)O[W](=O)(=O)O[W](=O)(=O)O1.O=[W]1(=O)O[W](=O)(=O)O[W](=O)(=O)O1 CGFYHILWFSGVJS-UHFFFAOYSA-N 0.000 claims abstract description 4
- 238000004519 manufacturing process Methods 0.000 claims description 12
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 claims description 9
- VSCWAEJMTAWNJL-UHFFFAOYSA-K aluminium trichloride Chemical group Cl[Al](Cl)Cl VSCWAEJMTAWNJL-UHFFFAOYSA-K 0.000 claims description 8
- YOUIDGQAIILFBW-UHFFFAOYSA-J tetrachlorotungsten Chemical group Cl[W](Cl)(Cl)Cl YOUIDGQAIILFBW-UHFFFAOYSA-J 0.000 claims description 8
- 239000008121 dextrose Substances 0.000 claims description 7
- 150000003839 salts Chemical class 0.000 claims description 7
- PNEYBMLMFCGWSK-UHFFFAOYSA-N Alumina Chemical compound [O-2].[O-2].[O-2].[Al+3].[Al+3] PNEYBMLMFCGWSK-UHFFFAOYSA-N 0.000 claims description 6
- KLZUFWVZNOTSEM-UHFFFAOYSA-K Aluminium flouride Chemical compound F[Al](F)F KLZUFWVZNOTSEM-UHFFFAOYSA-K 0.000 claims description 4
- VYZAMTAEIAYCRO-UHFFFAOYSA-N Chromium Chemical compound [Cr] VYZAMTAEIAYCRO-UHFFFAOYSA-N 0.000 claims description 3
- 229910052804 chromium Inorganic materials 0.000 claims description 3
- 239000011651 chromium Substances 0.000 claims description 3
- BDERNNFJNOPAEC-UHFFFAOYSA-N propan-1-ol Chemical compound CCCO BDERNNFJNOPAEC-UHFFFAOYSA-N 0.000 claims description 3
- 229910052782 aluminium Inorganic materials 0.000 claims description 2
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 claims description 2
- DIZPMCHEQGEION-UHFFFAOYSA-H aluminium sulfate (anhydrous) Chemical compound [Al+3].[Al+3].[O-]S([O-])(=O)=O.[O-]S([O-])(=O)=O.[O-]S([O-])(=O)=O DIZPMCHEQGEION-UHFFFAOYSA-H 0.000 claims description 2
- 238000007171 acid catalysis Methods 0.000 claims 2
- 239000003795 chemical substances by application Substances 0.000 claims 2
- GRYLNZFGIOXLOG-UHFFFAOYSA-N Nitric acid Chemical compound O[N+]([O-])=O GRYLNZFGIOXLOG-UHFFFAOYSA-N 0.000 claims 1
- 238000000151 deposition Methods 0.000 claims 1
- 229910017604 nitric acid Inorganic materials 0.000 claims 1
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 abstract 1
- 150000001844 chromium Chemical class 0.000 abstract 1
- 239000004615 ingredient Substances 0.000 abstract 1
- 108090000790 Enzymes Proteins 0.000 description 6
- 102000004190 Enzymes Human genes 0.000 description 6
- 230000009466 transformation Effects 0.000 description 5
- 230000000052 comparative effect Effects 0.000 description 4
- 239000012429 reaction media Substances 0.000 description 4
- 241000894007 species Species 0.000 description 4
- IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 description 3
- ZMANZCXQSJIPKH-UHFFFAOYSA-N Triethylamine Chemical compound CCN(CC)CC ZMANZCXQSJIPKH-UHFFFAOYSA-N 0.000 description 3
- 239000002253 acid Substances 0.000 description 3
- 239000003054 catalyst Substances 0.000 description 3
- 238000006555 catalytic reaction Methods 0.000 description 3
- 230000000694 effects Effects 0.000 description 3
- 238000005516 engineering process Methods 0.000 description 3
- 239000003960 organic solvent Substances 0.000 description 3
- 230000002441 reversible effect Effects 0.000 description 3
- 241000196324 Embryophyta Species 0.000 description 2
- 108700040099 Xylose isomerases Proteins 0.000 description 2
- 239000002585 base Substances 0.000 description 2
- 239000001913 cellulose Substances 0.000 description 2
- 229920002678 cellulose Polymers 0.000 description 2
- 238000005660 chlorination reaction Methods 0.000 description 2
- 239000007791 liquid phase Substances 0.000 description 2
- 150000002772 monosaccharides Chemical class 0.000 description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
- BNGXYYYYKUGPPF-UHFFFAOYSA-M (3-methylphenyl)methyl-triphenylphosphanium;chloride Chemical compound [Cl-].CC1=CC=CC(C[P+](C=2C=CC=CC=2)(C=2C=CC=CC=2)C=2C=CC=CC=2)=C1 BNGXYYYYKUGPPF-UHFFFAOYSA-M 0.000 description 1
- 239000004382 Amylase Substances 0.000 description 1
- 102000013142 Amylases Human genes 0.000 description 1
- 108010065511 Amylases Proteins 0.000 description 1
- 208000035126 Facies Diseases 0.000 description 1
- -1 Meanwhile Chemical compound 0.000 description 1
- 229920002472 Starch Polymers 0.000 description 1
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 1
- 229930006000 Sucrose Natural products 0.000 description 1
- 239000003513 alkali Substances 0.000 description 1
- 150000001412 amines Chemical class 0.000 description 1
- 235000019418 amylase Nutrition 0.000 description 1
- 238000004458 analytical method Methods 0.000 description 1
- 239000008346 aqueous phase Substances 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 229910052599 brucite Inorganic materials 0.000 description 1
- 238000002485 combustion reaction Methods 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 230000001276 controlling effect Effects 0.000 description 1
- 230000007515 enzymatic degradation Effects 0.000 description 1
- 230000002349 favourable effect Effects 0.000 description 1
- 239000012847 fine chemical Substances 0.000 description 1
- 235000013305 food Nutrition 0.000 description 1
- 235000021433 fructose syrup Nutrition 0.000 description 1
- 150000002303 glucose derivatives Chemical class 0.000 description 1
- 238000004128 high performance liquid chromatography Methods 0.000 description 1
- JJWLVOIRVHMVIS-UHFFFAOYSA-N isopropylamine Chemical compound CC(C)N JJWLVOIRVHMVIS-UHFFFAOYSA-N 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 239000011259 mixed solution Substances 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- 150000002829 nitrogen Chemical class 0.000 description 1
- UYDPQDSKEDUNKV-UHFFFAOYSA-N phosphanylidynetungsten Chemical compound [W]#P UYDPQDSKEDUNKV-UHFFFAOYSA-N 0.000 description 1
- 230000029553 photosynthesis Effects 0.000 description 1
- 238000010672 photosynthesis Methods 0.000 description 1
- 239000002243 precursor Substances 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 238000000746 purification Methods 0.000 description 1
- 239000002994 raw material Substances 0.000 description 1
- 239000000376 reactant Substances 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 210000000582 semen Anatomy 0.000 description 1
- WNUPENMBHHEARK-UHFFFAOYSA-N silicon tungsten Chemical compound [Si].[W] WNUPENMBHHEARK-UHFFFAOYSA-N 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 239000008107 starch Substances 0.000 description 1
- 235000019698 starch Nutrition 0.000 description 1
- 239000005720 sucrose Substances 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
- WFKWXMTUELFFGS-UHFFFAOYSA-N tungsten Chemical group [W] WFKWXMTUELFFGS-UHFFFAOYSA-N 0.000 description 1
- 229910052721 tungsten Inorganic materials 0.000 description 1
- 239000010937 tungsten Substances 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H1/00—Processes for the preparation of sugar derivatives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H3/00—Compounds containing only hydrogen atoms and saccharide radicals having only carbon, hydrogen, and oxygen atoms
- C07H3/02—Monosaccharides
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
The invention discloses a method for preparing fructose from glucose. According to the method, in the presence of an acid catalyst and low carbon alcohol, glucose undergoes an isomerization reaction in a closed high-pressure environment so as to prepare fructose, wherein the acid catalyst is one or more ingredients selected from a group consisting of tungsten salt, aluminium salt, chromium salt, phosphotungstic acid and silicotungstic acid. The method has advantages of mild condition, simple process and high conversion efficiency.
Description
Technical field
The present invention relates to monosaccharide isomerization, in particular it relates to the method by Dextrose production Fructose.
Background technology
Glucose, as a kind of monosaccharide of paramount importance in nature, abundance, is widely present in cellulose family plant
In, such as Semen Maydiss, Radix Betae, yam etc., these plants produce glucose by photosynthesis.It is industrial that to produce glucose mainly sharp
With amylase and saccharifying enzymatic degradation of starch or cellulose.Inexpensive glucose is converted into the fine chemicals of higher value
Prospect is very wide, such as Fructose.The using value of Fructose is high, can be used for fructose syrup preparation, food service industry and energy combustion
The fields such as material precursor.
At present, industrial produce that Fructose is main to obtain the mixed solution of Fructose and glucose from biological enzymolysis sucrose,
Separated purification finally obtains the crystalline solid of Fructose.Meanwhile, it is sugar source using glucose, in the work using glucose isomer enzyme
With under, glucose can be converted into Fructose through isomery.Both modes obtain the activity depending on enzyme for the production efficiency of Fructose,
Meanwhile, glucose and Fructose are affected by reversible reaction during the course of the reaction, lead to glucose transformation efficiency relatively low.Merit attention
, enzyme stability during the course of the reaction is notable on the impact of sugared transformation efficiency, need under certain sour environment these
Enzyme just can be survived, and the control to reaction key parameter is extremely strict, and the production cost of these enzyme is very simultaneously
Height is so that Fructose is somewhat limited on its synthesis technique.
Produce technical problem present in Fructose technique for solving biological enzyme, make glucose isomerization using catalysis technique
Cause concern.In aqueous phase system, mg-al brucite and mixing base catalyst etc. are proved glucose isomerase is had certain
Facilitation, but actual production effect has much room for improvement.In recent years, some organic faciess such as dimethyl sulfoxide (dmso), dimethyl methyl
Amide (dmf) etc. is used for glucose isomerase, and the conversion ratio of glucose makes moderate progress.Liu etc. (acs catalysis, 2014,
4:4295-4298) report, in the reaction medium of triethylamine, the highest yield of Fructose reaches 32%.(the journal such as yang
Of catalysis, 2015,330:474 484) report, have studied the reaction medium in 1,5,7- tri- azabicyclic decyl- 5- alkene
Middle Dextrose production Fructose, using a kind of organic alkali catalyst containing iron-base magnetic, after 120 DEG C of reaction 2h, Fructose highest yield
Reach 27%.Due to the use of these organic amines or nitrogen class solvent, consersion unit is required higher, and environment is caused necessarily
Pollution so that a large amount of productions of this technique receive obvious restriction.
Content of the invention
It is an object of the invention to provide a kind of method by Dextrose production Fructose, the method mild condition, operation are simple
And transformation efficiency is high.
To achieve these goals, the invention provides a kind of method by Dextrose production Fructose, the method is: in acid
In the presence of catalyst and organic solvent, glucose is carried out in high-pressure sealed environment isomerization reaction so that Fructose is obtained；Its
In, acid catalyst is selected from one or more of tungsten salt, aluminium salt, chromic salts, phosphotungstic acid and silico-tungstic acid.
By technique scheme, it is reaction medium that one aspect of the present invention passes through adopted low-carbon alcohols (alcohol of c1-c6),
Be conducive to regulating and controlling the reversible balance between glucose and Fructose molecule, improve glucose transformation efficiency and Fructose generates；The opposing party
Adopted acid catalyst (need not be carrier loaded) is passed through in face, may advantageously facilitate h in glucose molecule and translates into Fructose, significantly carries
High reaction efficiency (yield of Fructose may be up to 39.0%) and the selectivity of Fructose.Meanwhile, the isomerization method that the present invention provides
Reaction condition gentle, easy to operate, be conducive to simplifying Fructose production technology, and then make the method have higher economic effect
Beneficial and wide application prospect.
Other features and advantages of the present invention will be described in detail in subsequent specific embodiment part.
Brief description
Accompanying drawing is used to provide a further understanding of the present invention, and constitutes the part of description, with following tool
Body embodiment is used for explaining the present invention together, but is not construed as limiting the invention.In the accompanying drawings:
Fig. 1 is high-efficient liquid phase chromatogram in embodiment 1.
Specific embodiment
Hereinafter the specific embodiment of the present invention is described in detail.It should be appreciated that it is described herein concrete
Embodiment is merely to illustrate and explains the present invention, is not limited to the present invention.
The invention provides a kind of method by Dextrose production Fructose, the method is: in acid catalyst and low-carbon alcohols
In the presence of, glucose is carried out in high-pressure sealed environment isomerization reaction so that Fructose is obtained；Wherein, acid catalyst is selected from tungsten
One or more of salt, aluminium salt, chromic salts, phosphotungstic acid and silico-tungstic acid.
In the present invention, the concrete species of low-carbon alcohols can select in wide scope, but in order to improve Portugal further
The conversion ratio of grape sugar is it is preferable that low-carbon alcohols can be selected from the alcohol of c1-c4, such as a kind of or many in methanol, ethanol or propanol
Kind.
In the present invention, the consumption of raw material can select in wide scope, but in order to improve glucose further
Conversion ratio it is preferable that with respect to 100 weight portions glucose, the consumption of acid catalyst is 1-20 weight portion, the use of organic solvent
Measure as 300-2500 weight portion；It is highly preferred that with respect to the glucose of 100 weight portions, the consumption of acid catalyst is 1-10 weight
Part, the consumption of organic solvent is 400-2000 weight portion.
Meanwhile, the reaction condition of the present invention can select in wide scope, but in order to improve glucose further
Conversion ratio is it is preferable that isomerization reaction at least meets following condition: reaction temperature is 80-120 DEG C, and the response time is 0.5-
20h；It is highly preferred that the response time is 0.5-12h.
Additionally, the concrete species of tungsten salt can select in wide scope, but in order to improve turning of glucose further
Rate is it is preferable that tungsten salt is selected from tungsten chloride.
In the same manner, the concrete species of aluminium salt can select in wide scope, but in order to improve glucose further
Conversion ratio is it is preferable that aluminium salt is selected from one or more of aluminum chloride, aluminum sulfate, aluminium oxide, aluminum nitrate, aluminium fluoride；More preferably
Ground, aluminium salt is aluminum chloride.
In the same manner, the concrete species of chromic salts can select in wide scope, but in order to improve turning of glucose further
Rate is it is preferable that chromic salts is selected from Chlorizate chromium.
Hereinafter will be described the present invention by embodiment.
Embodiment 1
3g glucose, 0.15g tungsten chloride and 60g ethanol are placed in intermittent high-pressure reactor, then closed reactor
And reaction temperature is controlled to reaction 0.5h at 100 DEG C, after reaction terminates, reactant liquor is cooled down and adopts high performance liquid chromatography to divide
Analysis (high-efficient liquid phase chromatogram is shown in Fig. 1), result shows, the yield of Fructose is 37.2%.
Embodiment 2
Method according to embodiment 1 is carried out, and the yield of Fructose is 37.6%, except for the difference that the response time will extend to 2h.
Embodiment 3
Method according to embodiment 2 is carried out, and the yield of Fructose is 32.3%, except for the difference that reaction temperature is changed to 80 DEG C.
Embodiment 4
Method according to embodiment 2 is carried out, and the yield of Fructose is 26.8%, except for the difference that tungsten chloride is replaced by chlorination
Chromium.
Embodiment 5
Method according to embodiment 2 is carried out, and the yield of Fructose is 29.1%, except for the difference that tungsten chloride is replaced by chlorination
Aluminum.
Embodiment 6
Method according to embodiment 2 is carried out, and the yield of Fructose is 33.2%, except for the difference that tungsten chloride is replaced by phosphorus tungsten
Acid.
Embodiment 7
Method according to embodiment 2 is carried out, and the yield of Fructose is 25.0%, except for the difference that tungsten chloride is replaced by silicon tungsten
Acid.
Embodiment 8
Method according to embodiment 2 is carried out, and the yield of Fructose is 38.6%, except for the difference that ethanol is replaced by methanol.
Embodiment 9
Method according to embodiment 2 is carried out, and the yield of Fructose is 34.4%, except for the difference that ethanol is replaced by propanol.
Embodiment 10
Method according to embodiment 2 is carried out, and the yield of Fructose is 21.7%, except for the difference that reaction temperature is changed to 120 DEG C.
Embodiment 11
Method according to embodiment 2 is carried out, and the yield of Fructose is 39.0%, except for the difference that by the weight of tungsten chloride by
0.15g changes as 0.6g.
Embodiment 12
Method according to embodiment 2 is carried out, and the yield of Fructose is 31.9%, is except for the difference that changed the weight of glucose by 3g
It is changed to 15g.
Comparative example 1
Method according to embodiment 2 is carried out, and in product, no Fructose generates, and ethanol is except for the difference that all replaced by water.
Comparative example 2
Method according to embodiment 2 is carried out, and the yield of Fructose is 7.1%, except for the difference that 60g ethanol is replaced by 30g water
With 30g ethanol.
Comparative example 3
Method according to embodiment 2 is carried out, and the yield of Fructose is 6.4%, except for the difference that not using acid catalyst.
Indirectly demonstrated by above-described embodiment and comparative example: passing through adopted alcohol is reaction medium, can be favourable
Reversible balance between regulation and control glucose and Fructose molecule, improves glucose transformation efficiency and Fructose generates；Acid catalyst is (no
Need carrier loaded), h in glucose molecule can be may advantageously facilitate and translate into Fructose, greatly improve the choosing of reaction efficiency and Fructose
Selecting property.
The preferred embodiment of the present invention described in detail above, but, the present invention is not limited in above-mentioned embodiment
Detail, in the range of the technology design of the present invention, multiple simple variant can be carried out to technical scheme, this
A little simple variant belong to protection scope of the present invention.
It is further to note that each particular technique feature described in above-mentioned specific embodiment, in not lance
In the case of shield, can be combined by any suitable means, in order to avoid unnecessary repetition, the present invention to various can
The compound mode of energy no longer separately illustrates.
Additionally, combination in any can also be carried out between the various different embodiment of the present invention, as long as it is without prejudice to this
The thought of invention, it equally should be considered as content disclosed in this invention.
Claims (9)
1. a kind of method by Dextrose production Fructose is it is characterised in that methods described is: in depositing of acid catalyst and low-carbon alcohols
Under, described glucose is carried out in high-pressure sealed environment isomerization reaction be obtained described Fructose；Wherein, described acid catalysiss
Agent is selected from one or more of tungsten salt, aluminium salt, chromic salts, phosphotungstic acid and silico-tungstic acid.
2. method according to claim 1, wherein, described low-carbon alcohols are selected from one or more in methanol, ethanol or propanol.
3. method according to claim 1 and 2, wherein, with respect to the described glucose of 100 weight portions, described acid catalysiss
The consumption of agent is 1-20 weight portion, and the consumption of described low-carbon alcohols is 300-2500 weight portion.
4. method according to claim 3, wherein, with respect to the described glucose of 100 weight portions, described acid catalyst
Consumption is 1-10 weight portion, and the consumption of described low-carbon alcohols is 400-2000 weight portion.
5. method according to claim 3, wherein, described isomerization reaction at least meets following condition: reaction temperature is
80-120 DEG C, the response time is 0.5-20h.
6. the method according to claim 3 or 4, wherein, described tungsten salt is tungsten chloride.
7. the method according to claim 3 or 4, wherein, described aluminium salt is selected from aluminum chloride, aluminum sulfate, aluminium oxide, nitric acid
One or more of aluminum, aluminium fluoride.
8. method according to claim 7, wherein, described aluminium salt is aluminum chloride.
9. the method according to claim 3 or 4, wherein, described chromic salts is Chlorizate chromium.
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| CN201610681628.1A CN106336437B (en) | 2016-08-18 | 2016-08-18 | By the method for Dextrose production fructose |
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| CN201610681628.1A CN106336437B (en) | 2016-08-18 | 2016-08-18 | By the method for Dextrose production fructose |
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111100170A (en) * | 2018-10-26 | 2020-05-05 | 中国石油化工股份有限公司 | Method for producing fructose through glucose isomerization |
| CN111841521A (en) * | 2020-08-11 | 2020-10-30 | 浙江大学 | Preparation method and application of cellulose-based hydrothermal carbon-supported aluminum catalyst based on swelling regulation |
| CN112028949A (en) * | 2020-08-31 | 2020-12-04 | 安徽师范大学 | Method for preparing fructose by glucose catalysis |
| CN112354563A (en) * | 2020-11-27 | 2021-02-12 | 广东省科学院生物工程研究所 | Carbon catalyst loaded with phosphotungstic acid, and preparation method and application thereof |
| CN112746136A (en) * | 2019-10-31 | 2021-05-04 | 中国石油化工股份有限公司 | Chemical preparation method of fructose |
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| US3256270A (en) * | 1961-11-11 | 1966-06-14 | Boehringer & Soehne Gmbh | Process for the manufacture of d-fructose |
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| US3256270A (en) * | 1961-11-11 | 1966-06-14 | Boehringer & Soehne Gmbh | Process for the manufacture of d-fructose |
| CN103288887A (en) * | 2013-06-04 | 2013-09-11 | 北京大学 | Method for preparing ketose by utilizing aldose |
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| CHRISTOPHER M. LEW，ET AL.: ""One-Pot Synthesis of 5-(Ethoxymethyl)furfural from Glucose Using Sn-BEA and Amberlyst Catalysts"", 《IND. ENG. CHEM. RES.》 * |
| 张志文，等: ""化学法异构葡萄糖研究进展"", 《化学世界》 * |
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| CN111100170B (en) * | 2018-10-26 | 2021-06-04 | 中国石油化工股份有限公司 | Method for producing fructose through glucose isomerization |
| CN112746136A (en) * | 2019-10-31 | 2021-05-04 | 中国石油化工股份有限公司 | Chemical preparation method of fructose |
| CN112746136B (en) * | 2019-10-31 | 2022-03-08 | 中国石油化工股份有限公司 | Chemical preparation method of fructose |
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| CN112028949B (en) * | 2020-08-31 | 2021-09-28 | 安徽师范大学 | Method for preparing fructose by glucose catalysis |
| CN112354563A (en) * | 2020-11-27 | 2021-02-12 | 广东省科学院生物工程研究所 | Carbon catalyst loaded with phosphotungstic acid, and preparation method and application thereof |
| CN112354563B (en) * | 2020-11-27 | 2023-04-18 | 广东省科学院生物工程研究所 | Carbon catalyst loaded with phosphotungstic acid, and preparation method and application thereof |
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