CN106333942A - Application of licorice flavonoid compounds for preparing medicine for treating chronic non-atrophic gastritis - Google Patents

Application of licorice flavonoid compounds for preparing medicine for treating chronic non-atrophic gastritis Download PDF

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Publication number
CN106333942A
CN106333942A CN201610748232.4A CN201610748232A CN106333942A CN 106333942 A CN106333942 A CN 106333942A CN 201610748232 A CN201610748232 A CN 201610748232A CN 106333942 A CN106333942 A CN 106333942A
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CN
China
Prior art keywords
chronic
gastritis
atrophic gastritis
gastric
capsules
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN201610748232.4A
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Chinese (zh)
Inventor
彭峰
彭一峰
冀祖恩
莫宗成
周寒利
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Xinjiang Ann Pharmaceutical Ltd By Share Ltd
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Xinjiang Ann Pharmaceutical Ltd By Share Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Xinjiang Ann Pharmaceutical Ltd By Share Ltd filed Critical Xinjiang Ann Pharmaceutical Ltd By Share Ltd
Priority to CN201610748232.4A priority Critical patent/CN106333942A/en
Publication of CN106333942A publication Critical patent/CN106333942A/en
Pending legal-status Critical Current

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Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/335Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. cannabinols, methantheline

Abstract

The invention discloses application of licorice flavonoid compounds for preparing a medicine for treating chronic non-atrophic gastritis. The medicine prepared from the licorice flavonoid compounds is gastric ulcer suppression capsules. The medicine has the advantages that adaptation diseases of the gastric ulcer suppression capsules are increased, the effective components of licorice flavonoid compounds of the gastric ulcer suppression capsules have the good curative effect when the gastric ulcer suppression capsules are used for treating chronic non-atrophic gastritis (namely, chronic superficial gastritis), the certain conservation and restoration capacity for gastric mucosa is achieved, chronic non-atrophic gastritis (namely, chronic superficial gastritis) of more patients with gastric diseases can be effectively treated, and on the basis of mouse and rat zoological pharmacodynamic tests and professional pathological detection, it is found that the gastric ulcer suppression capsules really has the remarkable curative effect on chronic non-atrophic gastritis (namely, chronic superficial gastritis).

Description

Liquorice flavonoids compound is in preparation for treating the medicine of chronic non-atrophic gastritis In application
Technical field
The present invention relates to medicinal application technical field and in particular to liquorice flavonoids compound be used for treating in preparation chronic Application in the medicine of non-atrophic gastritis (i.e. chronic superficial gastritis).
Background technology
The peace original indication of gastric ulcer capsule: tonifying middle-Jiao and Qi, solution taking poison and growing muscle due, cure mainly stomach and duodenal bulbar ulcer, There is preferable curative effect to deficient cold type and Qi-stagnation type patient, and can be used for the maintaining treatment after ulcer healing.
Content of the invention
The purpose of the present invention is aiming at above-mentioned defect of the prior art, for expanding indication, there is provided licoflavone Class compound is used for treating the application in the medicine of chronic non-atrophic gastritis (i.e. chronic superficial gastritis) in preparation, that is, pacify stomach The new application in treating chronic non-atrophic gastritis (i.e. chronic superficial gastritis) of ulcer capsule.
To achieve these goals, the technical scheme that the present invention provides is: liquorice flavonoids compound is in preparation for slow Application in the medicine of the non-atrophic gastritis (i.e. chronic superficial gastritis) of property.
Further, above-mentioned application, the medicine of described liquorice flavonoids compound preparation is peace gastric ulcer capsule agent.
The invention has the benefit that expanding the indication of peace gastric ulcer capsule, licoflavone class chemical combination in peace gastric ulcer capsule Thing has preferable curative effect for chronic non-atrophic gastritis (i.e. chronic superficial gastritis), and has certain protection to stomach lining Repair ability, makes chronic non-atrophic gastritis (i.e. chronic superficial gastritis) in more patients with gastric disease be effectively treated, warp Cross the zoology test of pesticide effectiveness of mouse rat, through professional pathological examination, find peace gastric ulcer capsule to chronic non-atrophic stomach Scorching (i.e. chronic superficial gastritis) has significant curative effect really.
Brief description
Fig. 1-Fig. 7 is shown as pacifying the impact that gastric ulcer capsule causes rat chronic superficial gastritis model to ammoniacal liquor plus irregular diet Pathology figure.
Wherein, Fig. 1 is that No. 5 animal stomach textures of Normal group are normal, has no obvious pathological change;Fig. 2 is low dose No. 3 animal stomach lining partial denaturization necrosis of amount group are with acute and chronic cell infiltration and congestion and edema;Fig. 3 is model control group 2 The extensive degeneration necrosis of animal stomach lining are with neutrophil infiltration and proliferation of fibrous tissue;Fig. 4 is that No. 4 animal stomaches of middle dose group stick Film hyperemia is with focal acute and chronic cell infiltration;Fig. 5 is that No. 1 animal stomach lining mild hyperaemia of high dose group is scorching with being dispersed in acute and chronic Cellular infiltration;Fig. 6 is No. 6 animal stomach lining partial denaturization necrosis of Metoclopramide Tablets group with acute and chronic cell infiltration and hyperemia Oedema;Fig. 7 is No. 4 animal gastric mucosa congestions of capsule for relieving gastric trouble group with focal acute and chronic cell infiltration.
Fig. 8-Figure 14 is shown as pacifying the impact disease that gastric ulcer capsule causes rat chronic superficial gastritis model to synthesis stimulation Reason figure.
Wherein, Fig. 8 is that No. 4 animal stomach textures of Normal group are normal, has no obvious pathological change;Fig. 9 is low dose No. 6 animal gastric mucosa congestions of amount group are with focal acute and chronic cell infiltration;Figure 10 is that No. 5 animal stomach linings of model control group are extensive Degeneration necrosis are with neutrophil infiltration and proliferation of fibrous tissue;Figure 11 is No. 1 animal gastric mucosa congestion of middle dose group with focal Acute and chronic cell infiltration;Figure 12 is that No. 2 animal stomach lining mild hyperaemias companions of high dose group are dispersed in acute and chronic cell infiltration;Figure 13 is No. 6 animal stomach lining partial denaturization necrosis of Metoclopramide Tablets group with acute and chronic cell infiltration and congestion and edema;Figure 14 For No. 2 animal gastric mucosa congestions of capsule for relieving gastric trouble group with focal acute and chronic cell infiltration.
Specific embodiment
Embodiment 1:
Ammoniacal liquor add irregular diet cause rat chronic superficial gastritis model impact:
Experimental technique:
Prepared by model: carry out preliminary experiment by literature method, after modeling 12 weeks, take gastric tissue to carry out pathological observation, model group stomach group Knit and show as stomach lining degeneration necrosis with the pathological changes such as acute and chronic cell infiltration, congestion and edema and proliferation of fibrous tissue, table Bright modeling success.Formal when testing with method modeling, by sd rat 90, randomly select 10 rats as Normal group (to Give normal water), remaining rat is modeling group, all gives ammoniacal liquor and adds irregular diet stimulation: every rat adopts 0.02% ammoniacal liquor certainly By drinking;Give irregular diet stimulates simultaneously: 2d enough feedings feed, 1d fasting, circulation is carried out;Above stimulation mode continuously enters Row 12 weeks.
Animal packet and administration: after modeling terminates, therefrom choose the successful rat of modeling 60, be divided into model control group, Peace gastric ulcer capsule 328,164,82mg/kg, capsule for relieving gastric trouble 370mg/kg, Metoclopramide 3mg/kg, totally 6 groups, every group 10. Give relative medicine (Normal group and model control group give the purified water of same volume) by group, administered volume is 1ml/ 100g body weight, by daily single, successive administration 30 days.Administering mode: gavage, referred to during administration and after last dose Mark is observed.
Table 1 is shown as pacifying gastric ulcer capsule to chronic non-atrophic gastritis (i.e. chronic superficial gastritis) rat model stomach pathology Impact.
Table 1
Wherein, "-" is that stomach texture is normal, has no obvious pathological change;
"+" is that stomach lining mild hyperaemia companion is dispersed in acute and chronic cell infiltration;
" ++ " is for gastric mucosa congestion with focal acute and chronic cell infiltration;
" +++ " is for the necrosis of stomach lining partial denaturization with acute and chronic cell infiltration and congestion and edema;
" ++++" it is the extensive degeneration necrosis of stomach lining with neutrophil infiltration and proliferation of fibrous tissue.
Peace gastric ulcer capsule is to Pharmacodynamics model (chronic non-atrophic gastritis model is chronic superficial gastritis model) Indices (inclusion pathological index) all have significant treatment protective effect;Mouse peristole is slowed down and has obvious regulation to make With, but normal Gastric Motility, stomach liquid measure and acidity are acted on inconspicuous;And have obvious anti-inflammatory and analgesic effect.Close for clinical Ought to be with providing test basis.Rat test result is pointed out, and this test peace gastric ulcer capsule pharmacodynamics optimum effective dose is 328mg kg, effective dose be 164mg kg.
Finally it is noted that the foregoing is only the preferred embodiments of the present invention, it is not limited to the present invention, Although being described in detail to the present invention with reference to the foregoing embodiments, for a person skilled in the art, it still may be used To modify to the technical scheme described in foregoing embodiments, or equivalent is carried out to wherein some technical characteristics. All any modification, equivalent substitution and improvement within the spirit and principles in the present invention, made etc., should be included in the present invention's Within protection domain.

Claims (2)

1. liquorice flavonoids compound is used for the application in the medicine treating chronic non-atrophic gastritis in preparation.
2. application according to claim 1 is it is characterised in that the medicine of described liquorice flavonoids compound preparation is peace stomach Ulcer capsule agent.
CN201610748232.4A 2016-08-30 2016-08-30 Application of licorice flavonoid compounds for preparing medicine for treating chronic non-atrophic gastritis Pending CN106333942A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN201610748232.4A CN106333942A (en) 2016-08-30 2016-08-30 Application of licorice flavonoid compounds for preparing medicine for treating chronic non-atrophic gastritis

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN201610748232.4A CN106333942A (en) 2016-08-30 2016-08-30 Application of licorice flavonoid compounds for preparing medicine for treating chronic non-atrophic gastritis

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Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104721256A (en) * 2015-02-15 2015-06-24 新疆全安药业有限公司 Anwei Yang extract as well as preparation method and medical application thereof

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104721256A (en) * 2015-02-15 2015-06-24 新疆全安药业有限公司 Anwei Yang extract as well as preparation method and medical application thereof

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
林晓春等: "安胃疡抗炎镇痛作用及对慢性浅表性胃炎大鼠胃粘膜损伤的抑制", 《中药药理与临床》 *
林晓春等: "甘草总黄酮对慢性浅表性胃炎大叔胃粘膜损伤的保护作用", 《南方医科大学学报》 *
陈瑞发等: "安胃疡胶囊治疗慢性浅表性胃炎的疗效观察", 《江苏药学与临床研究》 *

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Application publication date: 20170118