CN106289889A - Device for sampling and analyzing mouth-exhaled gas molecules and nose-exhaled gas molecules simultaneously - Google Patents

Device for sampling and analyzing mouth-exhaled gas molecules and nose-exhaled gas molecules simultaneously Download PDF

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CN106289889A
CN106289889A CN201610761815.0A CN201610761815A CN106289889A CN 106289889 A CN106289889 A CN 106289889A CN 201610761815 A CN201610761815 A CN 201610761815A CN 106289889 A CN106289889 A CN 106289889A
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sampling
nasal
exhalation
way valve
breath
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CN201610761815.0A
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韩益苹
韩杰
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无锡市尚沃医疗电子股份有限公司
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    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00Sampling; Preparing specimens for investigation
    • G01N1/02Devices for withdrawing samples
    • G01N1/22Devices for withdrawing samples in the gaseous state
    • G01N1/2247Sampling from a flowing stream of gas
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00Sampling; Preparing specimens for investigation
    • G01N1/02Devices for withdrawing samples
    • G01N1/22Devices for withdrawing samples in the gaseous state
    • G01N1/24Suction devices
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers

Abstract

The invention relates to a device for sampling and analyzing mouth-exhaled NO and nose-exhaled NO simultaneously. The device is composed of a mouth exhalation sampling module (100), a nose exhalation sampling module (200) and an analysis module (300). On the basis that a technical standard of ATS/ERS on mouth and nose-exhaled NO determination is met, sampling and analyzing are conducted simultaneously, a result including the mouth-exhaled NO concentration and the nose-exhaled NO concentration can be obtained in one exhalation test, interference of physiological and pathological state changes is eliminated, and more reliable data is provided for clinical judgment.

Description

一种对口与鼻呼气)分子同时采样与分析装置 One kind of counterpart nasal exhalation) molecule simultaneous sampling and analysis device

技术领域 FIELD

[0001] 本发明涉及一种内源性气体信号分子口呼气和鼻呼气采样与分析装置。 [0001] The present invention relates to a signal derived gas molecules within an oral and a nasal exhalation breath sampling and analysis device.

背景技术 Background technique

[0002] 呼出气NO是国际公认的气道炎症标志物。 [0002] exhaled NO is internationally recognized as a marker of airway inflammation. 美国胸科学会(ATS)与欧洲呼吸学会(ERS) 2005年制定了呼出气NO测定的标准化技术,描述了对口呼气与鼻呼气NO分别测定的方法,口呼气NO测定用来检测哮喘与慢阻肺等肺部疾病的下气道炎症,鼻呼气NO测定则用来检测鼻炎与鼻窦炎等鼻部疾病的上气道炎症。 American Thoracic Society (ATS) and European Respiratory Society (ERS) in 2005 to develop standardized technology exhaled NO measurement, describes a method counterparts breath and nasal NO were measured breath, mouth breath NO measurement is used to detect asthma COPD and other lung diseases of the lower airways inflammation, nasal breath NO measurement is used to detect upper airway inflammation and rhinitis, nasal sinusitis and other diseases. 目前所有的公开技术,例如中国尚沃的纳库仑呼气分析仪(专利CN103487489A与CN203561610U)与瑞典的NIOX化学发光分析仪,在呼吸科、儿科、耳鼻喉科等科室都已经有了广泛的应用,可以分别进行口呼气和鼻呼气NO测试。 At present, all of the disclosed technology, for example, China is still fertile analysis of nano-coulombs breath analyzer (patent CN103487489A and CN203561610U) and Sweden NIOX chemiluminescence analyzer, in respiratory medicine, pediatrics, ENT and other departments have been widely used It can be oral and nasal exhalation breath test NO, respectively.

[0003] 然而,临床上很多情况需要同时测定口呼气与鼻呼气一氧化氮,用来检测上下气道炎症合并的情况,例如哮喘合并鼻炎的情况。 [0003] However, many of the clinical cases need to breath nasal exhalation port determination of nitric oxide, for detecting the combined upper and lower airway inflammation, for example in the case of asthma with rhinitis. 流行病学及临床循证已经表明,30-40%的鼻炎患者患有哮喘,通常呼吸医学也将鼻炎与哮喘叫做同一气道,同一疾病。 Epidemiology and clinical evidence-based has shown that 30-40% of rhinitis patients suffering from asthma, respiratory medicine will usually rhinitis and asthma is called the same airway, the same disease. 对口与鼻呼气N0,分别测定需要患者两次测试,由于两次可能处在不同的生理病理状态,难以建立上下气道炎症的直接关联,而同时测定,患者只需一次测试,处在相同的生理病理状态,可建立上下气道炎症的直接关联。 N0 counterparts nose exhalation, two tests were measured in a patient in need, since the two may be in different physiopathological condition is difficult to establish a direct association of the upper and lower airway inflammation, measured at the same time, patients with a single test, in the same the physiological and pathological state, a direct association of the upper and lower airway inflammation.

[0004] 本发明的目的就是开发一种能够对口呼气或鼻呼气同时进行采样与分析的装置, 以满足临床需求。 [0004] The object of the present invention is to develop an exhalation mouth or nasal exhalation simultaneously sampling and analysis means, in order to meet clinical needs.

发明内容 SUMMARY

[0005] 本发明提供了一种对口与鼻呼气NO同时采样与分析的装置,在满足ATS/ERS关于口与鼻呼气NO测定的技术标准的基础上,进行同时采样与分析,一次呼气测试就可以得到口呼气与鼻呼气一氧化氮浓度结果,排除生理病理状态变化的干扰,为临床判断提供更可靠的数据。 [0005] The present invention provides a nasal exhalation NO counterparts simultaneous sampling and analysis device, meet ATS / ERS based on technical standards nasal exhalation port on the NO measurement, simultaneous sampling and analysis, a call test gas can be obtained with the nasal exhalation port tidal concentration of NO results, eliminate interference physiological and pathological changes state, providing a more reliable data for clinical judgment.

[0006] 国际标准推荐的口呼气采样流量为50ml/s,呼气压力5-20cmH2〇,呼气时间6-10S, 排空与稳定时间3~5s,米样时间Is或50ml气体。 [0006] International Standard recommended sampling port expiratory flow of 50ml / s, 5-20cmH2〇 exhalation pressure, expiratory time 6-10S, emptying the settling time 3 ~ 5s, m 50ml injection time Is or gas. 国际标准推荐的鼻呼气米样流量为5_50ml/ s,优选10_20ml/s,口腔压力>5cmH2〇,呼气时间10s,排空与稳定时间5s,采样时间5s或50ml 气体。 International Standard recommended nasal expiratory flow meter comp 5_50ml / s, preferably 10_20ml / s, mouth pressure> 5cmH2〇, expiratory time 10s, and stability emptying time 5s, 5s or 50ml gas sampling time. 口呼气与鼻呼气采样的压力要求、呼气时间要求有一定重合,这为同时进行口与鼻呼出气采样的方法提供了实现基础。 Nasal exhalation breath sampling port and pressure requirements, require a certain expiration time overlap, which is the method of simultaneously sampling the exhaled breath mouth and nose to provide a basis.

[0007] 然而,口与鼻呼出气采样的方式不同,口呼气是主动呼气采样,鼻呼气时被动抽气采样,必须要有一个同步的控制参数才可以实现同时采样的目的,即在口呼气的同时,装置通过该控制参数的变化开启或关闭抽气部件,同步采集鼻呼气。 [0007] However, different mouth and a nose exhaled breath sampling mode, is active exhalation breath sampling port, exhaust passive sampling, there must be a synchronous control object parameters can achieve simultaneous sampling nasal breath, i.e., while the exhalation port, means to open or close the suction member, the synchronous acquisition nasal exhalation by varying the control parameter. 这里的控制参数可以是口呼气压力参数,通过在口呼气采样通路上的配置压力传感器来实现口呼压力参数的采集, 同时通过对采集数据的处理和判断来控制鼻呼气采集装置的开启或关闭。 Here the control parameter may be a parameter expiratory pressure port, the pressure to achieve a spoken acquisition parameters by sampling the exhalation port disposed on the pressure sensor passage, through processing of data collection and determination to control nasal exhalation taking apparatus on or off.

[0008] -种对口与鼻呼气NO同时米样与分析的装置由口呼米样模块(100)、鼻呼米样模块(200)与分析模块(300)组成。 [0008] - species counterparts exhalation nasal NO means simultaneously meters and analysis of samples by a spoken rice samples module (100), the nose-like call meter module (200) and analysis module (300) components.

[0009] 所述口呼采样模块(100)由流量调节器(101)、缓冲室一(103)和两通阀(104)串联组成,气路中连接有压力传感器(105);所述鼻呼采样模块(200)由流量传感器(201)、缓冲室二(202)、和采样栗(203)串联组成;所述分析模块(300)由三通阀一(301)、三通阀二(302)、分析栗(303)、湿度调节器(304)、N0传感器(305)、N0过滤器(306)组成,其中三通阀一(301)用于切换分析缓冲室一或缓冲室二中的样品气,三通阀二(302)用于切换分析样品气或经NO过滤器(306)过滤后的零点气。 [0009] The sampling module exhalation port (100) by a flow regulator (101), a buffer chamber (103) and the two-way valve (104) in series, the gas passage connecting a pressure sensor (105); said nose call sampling module (200) by the flow rate sensor (201), two buffer chamber (202), and sampling chestnut (203) in series; the analysis module (300) a three-way valve (301), two three-way valve ( 302), analysis of Li (303), the humidity controller (304), N0 sensor (305), N0 filter (306), wherein a three-way valve (301) for switching a chamber or buffer Assay buffer chamber II sample gas, two-way valve (302) for switching the samples were analyzed by gas NO or the filter (306) filtering the zero gas.

[0010] 对于呼气样本采集阶段:受试者口含与口呼采样模块(100)连接好的呼气过滤器, 同时一个鼻孔通过鼻呼过滤器与鼻呼采样模块(200)连接好。 [0010] For the breath sample collection stage: subject buccal ligated exhalation port and exhalation filter sampling module (100), while a call nose nostril connected sampling module (200) via a nasal exhalation filter. 受试者开始呼气后,压力传感器(105)会实时监测口呼压力,流量调节器(101)控制呼气流速在要求的范围内,当监测到有压力信号时,两通阀(104)开启,口呼气进入缓冲室一(103),需要排空的口呼气从两通阀(104)后端排出,符合要求的口呼气样本保留在缓冲室一(103)中;当口呼压力满足>5cmH 20 时,采样栗(203)自动开启,驱动鼻腔气体进入缓冲室二(202),需要排空的鼻呼气从采样栗(203)后端排出,符合要求的比呼气样本保留在缓冲室二(202)中,流量传感器(201)监测整个采样过程的流量,实时反馈和调整采样栗控制参数,维持采样流速恒定;当口呼气采样满足要求后,两通阀(104)关闭,呼气停止后,压力传感器监测到压力为0,采样栗(203)收到信号后自动关闭,停止鼻呼气采样;通过口呼压力数据的交互反馈,使得口呼气与鼻呼气的采样压力满足要求、采样 Subject after exhalation begins, the pressure sensor (105) real time monitoring of a spoken pressure, flow regulator (101) controlling expiratory flow rate within the required range, and when the monitored pressure signals, two-way valve (104) open, into the buffer chamber an exhalation port (103), the need to empty from the discharge port two-way exhalation valve (104) rear, to meet the requirements port breath sample chamber retained in a buffer (103); and when a spoken pressure satisfies> 5cmH 20, the sampling chestnut (203) automatically turns on, driving gas into the buffer chamber two nose (202), nasal exhalation need to empty (203) is discharged from the rear end of the sampling Li, breath samples meet the requirements ratio retained in the buffer chamber two (202), flow sensor (201) to monitor traffic across the sampling process, real-time feedback and adjustment of the sample Li control parameters, to maintain the sample flow rate constant; when the mouth breath samples meet the requirements, two-way valve (104) closed, exhale stopped, the pressure sensor detects a pressure of 0, Li sampling (203) the received signal automatically closed to stop the nasal breath samples; feedback pressure through a spoken interaction data, such that exhalation port and exhalation nasal sampling the pressure to meet the requirements, the sampling 时间保持同步,实现同时口鼻呼气采样。 Time to keep pace, nose and mouth at the same time achieve breath sample.

[0011] 对于呼气样本分析阶段:采样结束后装置会自动开启分析栗(202),缓冲室一(103)中的口呼气样本被驱动经过三通阀一(301)、三通阀二(302)、湿度调节器(203)后进入NO传感器(204);缓冲室一(103)中的口呼气样本分析完成后,开启三通阀一(301),分析缓冲室二(202)中的鼻呼气样本,分析完成后,开启三通阀二(302),分析经过NO过滤器(306)过滤后的零点气;通过计算三段电流值就可以得到口呼气与鼻呼气的NO浓度。 [0011] For the breath sample analysis phase: When the sample analysis device is automatically turned chestnut (202), the breath sample port a buffer chamber (103) is driven through a three-way valve (301), two three-way valves (302), the humidifier (203) into the NO sensor (204); in a buffer chamber (103) opening breath after completion of sample analysis, a three-way valve opening (301), two in assay buffer chamber (202) nasal breath sample, the analysis is completed, open two-way valve (302), analysis of NO through the filter (306) filtering the zero gas; three sections by calculating the current value can be obtained with the nasal breath exhalation port NO concentration.

[0012] 本发明的另一种实现方式是离线同时采集口呼气与鼻呼气样本到气袋后再进行分析,离线采样装置较在线的采样分析一体装置可以更好的小型化,便于携带,可以在远离仪器的地点进行样品采集,拓宽了仪器的适用环境;也可以实现多次呼气采样,特别适合儿童、老人、重症患者等难以满足呼气要求的受试者。 [0012] Another embodiment of the present invention is implemented off-line while the acquisition port nasal exhalation breath samples to be analyzed after the bag, the more off-line sampling means sampling and analysis means may be integrally better miniaturization, portability It can be carried out at a location away from the instrument sample collection, broadening the application of environmental instruments; can also achieve multiple breath sampling, especially for difficult to meet the requirements of the subjects exhale children, the elderly, critically ill patients and so on.

[0013] -种对口与鼻呼气同时采样的装置由口呼采样模块(100)、鼻呼采样模块(200)与采样气袋一(501)、采样气袋二(502)构成,所述口呼采样模块(100)由流量调节器(101)和三通阀一(106)串联组成,气路中连接有压力传感器(105),其中三通阀一(106)用于切换采样气排空或进入采样气袋一(501);所述鼻呼采样模块(200)由流量传感器(201)、采样栗(203)和三通阀二(205)串联组成,其中三通阀二(205)用于切换采样气排空或进入采样气袋二(502)。 [0013] - means species counterparts nasal exhalation simultaneously sampled by a spoken sampling module (100), nasal respiratory sampling module (200) with a sampling bag (501), two sampling bag (502), and the a spoken sampling module (100) by a flow regulator (101) and a three-way valve (106) in series, the gas passage connecting a pressure sensor (105), wherein a three-way valve (106) for switching the exhaust gas sampling space or into a sampling bag (501); the call nasal sampling module (200) by the flow rate sensor (201), Li samples (203) and two three-way valve (205) connected in series, wherein the two-way valve (205 ) for switching the evacuated gas sampling bag or into two samples (502).

[0014] 受试者口含与口呼采样模块(100)连接好的呼气过滤器,同时一个鼻孔通过鼻呼过滤器与鼻呼采样模块(200)连接好。 [0014] buccal subject with a spoken sampling module (100) connected to good exhalation filter, and connected to one nostril by nasal exhalation nasal respiratory filter sampling module (200). 受试者开始呼气后,压力传感器(105)会实时监测口呼压力,流量调节器(101)控制呼气流速在要求的范围内,切换三通阀一(106)按要求进行排空后,符合要求的口呼气样本采集到采样气袋一(501)中;当口呼压力满足>5cmH20时,采样栗(203)自动开启,驱动鼻腔气体进入鼻呼采样模块(200),切换三通阀二(205)按要求进行排空后,符合要求的鼻呼气样本采集到采样气袋二(502)中,流量传感器(201)监测整个采样过程的流量,实时反馈和调整采样栗控制参数,维持采样流速恒定;当口呼气采样满足要求后,提示采样成功,呼气停止,压力传感器监测到压力为0,采样栗(203)收到信号自动关闭,停止鼻呼气采样。 Subject after exhalation begins, the pressure sensor (105) real time monitoring of a spoken pressure, flow regulator (101) controlling expiratory flow rate in the range of claims, a switching three-way valve (106) is emptied as required , meet the requirements of the sample collection port breath sampling bag to a (501); when the pressure satisfies a spoken> 5cmH20, the sampling chestnut (203) automatically turns on, driving gas into the nasal cavity the nasal respiratory sampling module (200), the three-way two valves (205) after emptying required, to meet the requirements of the nasal breath sample collection bag to the two samples (502) flow rate, the flow rate sensor (201) monitors the entire sampling process, and real-time feedback control to adjust the sampling parameters Li maintaining a constant sampling flow rate; breath sampling port when meet the requirements, hint samples successfully, stopping exhalation, the pressure sensor detects a pressure of 0, Li sampling (203) the received signal automatically closed to stop the nasal breath sampling.

[0015] 当受试者一次采样不能达到采样气量要求时,可以重复呼气采样,装置每次采集符合要求的样品气到采样气袋一(501)和采样气袋二(502),直至达到要求的气量。 [0015] When the subject is not a sample gas reaches the sampling requirements may be repeated breath sampling means samples each acquisition sample gas to meet the requirements of a bag (501) and two sampling bag (502), until gas requirements.

[0016] 将采集到的口呼气与鼻呼气样品气袋送到分析仪上进行分析,得到口呼与鼻呼的测试结果。 Analysis to the analyzer [0016] The collected oral exhalation breath sample bag nose, nasal call to obtain a spoken test results. 使用的分析仪不限于电化学分析仪和化学发光仪。 Any use of the analyzer to the analyzer and an electrochemical chemiluminescence analyzer.

[0017] 如采样环境较为恶劣,环境NO浓度很高,为避免环境NO对测试结果的影响,需要对口呼与鼻呼的吸入气体进行过滤。 [0017] The sampling environment is more severe, high ambient concentration of NO, NO in order to avoid environmental impact on the test results, need to call their counterparts in the suction filter of the gas nasal call. 可利用尚沃的吸气过滤器(专利CN105388278A、 CN205301325U、CN303693090S),在单向阀组(13)与细菌过滤棉(9)之间做一个出口,连接一个单向阀(21)后,再连接到鼻呼头(22)上,与受试者的一侧鼻孔相连。 After available SUNWORLD the suction filter (Patent CN105388278A, CN205301325U, CN303693090S), to make a filter between the outlet and the one-way valve in bacteria (13) cotton (9), connected to a check valve (21), and then the call is connected to the nose head (22) connected to the nostril of the subject. 受试者在开始呼气采样前,手持吸气过滤器,先呼净余气,用呼气过滤器(17)罩住口部深吸气,环境气经高锰酸钾滤料(I 1)和活性炭滤料(12)过滤后,经细菌过滤棉(9)与单向阀组(13)后进入口腔;呼气时单向阀组(13)关闭,呼气通过管腔(20)进入口呼采样模块(100),同时采样栗(203)开始鼻呼采样,环境气经滤料高锰酸钾和活性炭过滤后,再经旁路的单向阀(21),从一侧鼻孔进入鼻腔,然后从另一侧鼻孔出来,进入鼻呼采样模块(200)。 Sampling the subject before the start of exhalation, hand-held suction filter, to call a net gas (17) covering the mouth with the exhalation filter deep inspiration, potassium permanganate ambient air through filter (I 1) and the activated carbon filter (12) filtering, filtration through a bacteria cotton (9) and the check valve (13) into the mouth; one-way exhalation valve (13) closed, through the lumen into the exhalation (20) a spoken sampling module (100), while Li sampling (203) the start call nasal sampling, the ambient air through a filter and activated carbon filter potassium permanganate, and then through the one-way bypass valve (21), enters from the side of the nose nose, nostril and out the other side, into the nasal respiratory sampling module (200). 利用这样一个口鼻共用的吸气过滤器,就可以很好的解决环境NO干扰的问题,确保测试结果的准确性。 With such a muzzle common suction filter, it can solve environmental issues NO interference to ensure the accuracy of test results.

附图说明 BRIEF DESCRIPTION

[0018] 图1 一种对口与鼻呼气NO同时采样与分析的装置结构示意图。 [0018] FIG 1. An exhalation nasal NO counterparts while the device structure Sampling and Analysis FIG.

[0019] 图2-种对口与鼻呼气联合采样的装置结构示意图。 [0019] FIG structural diagram of apparatus 2- species counterparts combined exhalation nasal samples.

[0020] 图3 口鼻共用的吸气过滤器结构示意图。 [0020] FIG schematic structural diagram of suction filter 3 common to the nose and mouth.

具体实施方式 Detailed ways

[0021] 具体实施例一本实施例利用图1所示装置,按照预设的采样流量和排空要求,进行口呼气与鼻呼气的同步采样与分析。 [0021] DETAILED embodiment apparatus shown in one case using FIG embodiment, according to a preset sampling flow and emptying requirements, simultaneous sampling and analysis and breath nasal exhalation port.

[0022] 以下详细述整个采集和分析过程: 1)采样准备阶段:受试者要求测试前一小时不得饮食、抽烟和运动;测试前,医务人员会在软件模块上输入本次测试采用的鼻呼采样流量IOmVs和受试者的年龄、性别、身高、体重等参数,软件内算法会自动计算出受试者采样所需排空时间和采样时间;医务人员在鼻呼气采样模块的接口接上鼻呼过滤器,鼻呼过滤器包含一个硅胶材质的鼻呼头和一个细菌过滤器,鼻呼头呈橄榄形状,可以很好的贴合鼻孔部位,防止漏气,细菌过滤器可以过滤细菌、粉尘及液态水;同时在口呼气采样模块的接口上接好吸气与呼气过滤器,呼气过滤器上有细菌过滤膜,同样可以过滤细菌、粉尘及液态水,吸气过滤器可过滤口与鼻的吸入气;鼻呼过滤器和呼气过滤器为专人专用耗材,以避免交叉感染。 [0022] The following detailed later the entire collection and analysis: 1) Sample preparation phase: the subject can not be required to test one hour before eating, smoking, and exercise; prior to testing, medical personnel may enter the nasal The test uses a software module on a call age, sex, height, weight and other parameters of the sample flow rate IOmVs subject, the software algorithm automatically calculates the time required for emptying the subject sampling time and sampling; medical personnel interfaces connected to the sampling module of the nasal exhalation nasal respiratory filter, nasal exhalation filter comprises a silicone material and a nasal exhalation bacterial filter head, the first call was olive nose shape, can be a good fit nose portion, to prevent leakage, a bacterial filter can filter bacteria , dust and liquid water; simultaneously connected to the exhalation port sampling module interface good inspiratory and expiratory filter, membrane filter bacteria, bacteria can also be filtered, dust and liquid water on the exhalation filter, suction filter mouth and nose to filter the suction air; nasal respiratory filters and exhalation filter to someone for supplies, to prevent cross-infection.

[0023] 2)呼气样本采集阶段:受试者一个鼻孔通过鼻呼过滤器与鼻呼气采样装置连接好,另一个鼻孔通过鼻呼头(22)与吸气过滤器连接好。 [0023] 2) breath sample collection stage: the subject by a nasal nostril and nasal respiratory exhalation filter connected sampling means, connected to the other nostril by nasal respiratory suction filter head (22) is good. 受试者手持吸气过滤器,先呼净余气,用呼气过滤器罩(17)住口部深吸气后开始呼气后,压力传感器(105)会实时监测口呼压力,流量调节器(101)控制呼气流速在50± 5ml/s的范围内,当监测到有压力信号时,两通阀(104)开启,口呼气进入缓冲室一(103),需要排空的口呼气从两通阀(104)后端排出,符合要求的口呼气样本保留在缓冲室一(103)中;当口呼压力满足>5cmH 20时,采样栗(203)自动开启,以lOml/s的流速驱动环境气经滤料高锰酸钾和活性炭过滤后,再经旁路的单向阀(21),从一侧鼻孔进入鼻腔,然后从另一侧鼻孔出来进入缓冲室二(202),需要排空的鼻呼气从采样栗(203)后端排出,符合要求的比呼气样本保留在缓冲室二(202)中;当口呼气采样满足要求后,两通阀(104)关闭,呼气停止,压力传感器监测到压力为0,采样栗(203)收到信号自动关闭,停止鼻呼 After the subject held suction filter, to a net gas exhalation, the exhalation filter with a housing (17) shut exhalation unit starts deep inspiration, the pressure sensor (105) real time monitoring of a spoken pressure, flow regulator (101) controlling expiratory flow within the range of 50 ± 5ml / s, and when the monitored pressure signals, two-way valve (104) is turned into the buffer chamber an exhalation port (103), the need to empty a spoken gas is discharged from the (104) through the rear end of the two valves, the opening to meet the requirements breath sample retained in a buffer chamber (103); when the pressure satisfies a spoken> 5cmH 20, the sampling chestnut (203) is automatically opened to lOml / s gas flow rate through the filter driving environment after potassium permanganate and activated carbon filter, then through the one-way bypass valve (21), the nostrils into the nasal cavity from one side, the other side and then out into the nostril two buffer chamber (202) need evacuated expiratory nose (203) is discharged from the rear end of the sampling Li, to meet the requirements than in the second breath sample retained (202) in the buffer chamber; breath sampling port when meet the requirements, two-way valve (104) is closed , stopping exhalation, the pressure sensor detects a pressure of 0, Li sampling (203) the received signal automatically closed to stop the nasal respiratory 采样。 Sampling.

[0024] 3)呼气样本分析阶段:采样结束后装置会自动开启分析栗(202),缓冲室一(103) 中的口呼气样本以lml/s的被驱动经过三通阀一(301)、三通阀二(302)、湿度调节器(203) 后进入NO传感器(204);缓冲室一(103)中的口呼气样本分析30s后,开启三通阀一(301),分析缓冲室二(202)中的鼻呼气样本,分析30s后,开启三通阀二(302),分析经过NO过滤器(306)过滤后的零点气,同样分析30s;通过计算三段电流值就可以得到口呼气与鼻呼气的NO浓度。 [0024] 3) the breath sample analysis phase: When the sample analysis device is automatically turned chestnut (202), in a buffer chamber (103) to be driven breath sample port lml / s through a three-way valve (301 ), the two-way valve (302), the humidity controller (203) into the NO sensor (204); a rear of the buffer chamber (103) analyzes the breath sample port 30s, opening a three-way valve (301), analysis two nasal breath sample buffer chamber (202), the analysis of 30s, open two-way valve (302), through the analysis of NO zero gas filter (306) filters, the same analysis 30s; three sections by calculating a current value can be obtained mouth breath exhalation nasal NO concentration.

[0025] 表1中收集了3位受试者在同一采样流速下的3次重复采样分析结果,由表可知,利用本装置采集和分析口与鼻呼气样品可以获得良好的重复性。 [0025] Table 1 3 subjects collected a sample analysis repeated three times in the same sampling flow rate, apparent from the table, using the present apparatus to collect and analyze the breath sample mouth and nose possible to obtain good reproducibility. 为尽量避免生理状态变化的影响,要求每次测试间隔20-30分钟。 To minimize the influence of changes in physiological state, each test requires 20-30 minutes intervals.

[0026] 具体实施例二 [0026] DETAILED second embodiment

Figure CN106289889AD00071

本实施例利用图2所示装置,在口与鼻呼气联合采样装置上采集好口呼气与鼻呼气样品气袋,再将采集到的样本送到分析仪上进行分析,得到口呼与鼻呼的测试结果。 Embodiment of the present embodiment using the apparatus shown in FIG. 2, the exhalation taking good mouth nasal exhalation breath sample bag with a joint sampling means, and then collected the samples in the mouth and nose to the analyzer for analysis, to give a spoken and the test results of nasal call.

[0027] 受试者口含与口呼采样模块(100)连接好的呼气过滤器,同时一个鼻孔通过鼻呼过滤器与鼻呼采样模块(200)连接好。 [0027] buccal subject with a spoken sampling module (100) connected to good exhalation filter, and connected to one nostril by nasal exhalation nasal respiratory filter sampling module (200). 受试者开始呼气后,压力传感器(105)会实时监测口呼压力,流量调节器(101)控制呼气流速在50 ±5ml/s的范围内,切换三通阀一(106)按要求进行排空后,符合要求的口呼气样本采集到采样气袋一(501)中;当口呼压力满足>5cmH2〇时,采样栗(203)自动开启,以lOml/s的流速驱动鼻腔气体进入鼻呼采样模块(200),切换三通阀二(205)按要求进行排空后,符合要求的鼻呼气样本采集到采样气袋二(502)中;当口呼气累计的采样时间满足3s要求后,装置提示采样成功,呼气停止后,压力传感器监测到压力为〇,采样栗(203)收到信号自动关闭,停止鼻呼气采样。 Subject after exhalation begins, the pressure sensor (105) real time monitoring of a spoken pressure, flow regulator (101) controlling expiratory flow rate in the range of 50 ± 5ml / s, the switching a three-way valve (106) as required after emptying, meet the requirements of the sample collection port breath sampling bag to a (501); when the pressure satisfies a spoken> when 5cmH2〇, Li sample (203) is automatically turned on to a flow rate of lOml / s drive gas into the nasal cavity call nasal sampling module (200), two switching three-way valve (205) after emptying required, to meet the requirements of the nasal breath sample collection bag to the two samples (502); when the accumulated mouth breath sampling time satisfies 3s after wherein the means hint samples successfully stopped after exhalation, the pressure sensor detects a pressure square, Li sampling (203) the received signal automatically closed to stop the nasal breath sampling.

[0028] 将采集到的口呼气与鼻呼气样品气袋送到尚沃纳库仑分析仪上进行分析,得到口呼与鼻呼的测试结果。 [0028] The collected oral nasal exhalation breath samples to be analyzed on the gas bag still Wonakulun analyzer, test results obtained in a spoken call nose.

[0029] 表2中收集了3位受试者利用不同装置进行口呼气与鼻呼气测定的测试结果,做了3种采样分析方式:(1)利用图1所示装置,同时采样后在线分析;(2)利用图2所示装置,同时一次呼气采样后离线分析;(3)利用图2所示装置,同时多次呼气采样后离线分析。 [0029] Table 2. The test results were collected three different subjects using a nasal exhalation port means exhalation measurement, sampling and analysis made three kinds of ways: the device shown in FIG. 1 (1) using the FIG., While the sample line analysis; means 2 shown in (2) using the FIG., while off-line analysis of the sampled exhalation time; means shown in FIG. 2 (3) using the FIG., while off-line analysis breath sampling times. 由表可知,3种方式的测试结果一致性较好,说明离线装置可以在某些场合替代采样分析一体化装置,拓宽了仪器的适用环境与适用人群。 It is shown that the test results are three ways of better consistency, indicating that the device can replace offline sampling and analysis device integration, broaden the application of environmental instruments with the crowd in some cases. 为尽量避免生理状态变化的影响,要求每次测试间隔20-30分钟。 To minimize the influence of changes in physiological state, each test requires 20-30 minutes intervals.

Figure CN106289889AD00081

Claims (6)

1. 一种对口与鼻呼气NO同时米样与分析的装置由口呼米样模块(100)、鼻呼米样模块(200)与分析模块(300)组成,其特征在于: 所述口呼采样模块(100)由流量调节器(101)、缓冲室一(103)和两通阀(104)串联组成,气路中连接有压力传感器(105); 所述鼻呼采样模块(200)由流量传感器(201)、缓冲室二(202)、和采样栗(203)串联组成; 所述分析模块(300)由三通阀一(301)、三通阀二(302)、分析栗(303)、湿度调节器(304)、NO传感器(305)、N0过滤器(306)组成,其中三通阀一(301)用于切换分析缓冲室一或缓冲室二中的样品气,三通阀二(302)用于切换分析样品气或经NO过滤器(306)过滤后的零点气。 An exhalation nasal NO counterpart means simultaneously meters and analysis of samples by a spoken rice samples module (100), the nose-like call meter module (200) and analysis module (300), and is characterized in that: said port call sampling module (100) by a flow regulator (101), a buffer chamber (103) and the two-way valve (104) in series, the gas passage connecting a pressure sensor (105); the call nasal sampling module (200) a flow rate sensor (201), two buffer chamber (202), and sampling chestnut (203) in series; the analysis module (300) a three-way valve (301), two three-way valve (302), analysis of Li ( 303), the humidity controller (304), NO sensor (305), N0 filter (306), wherein a three-way valve (301) for switching Assay buffer chamber or buffer chamber a sample gas in two, three two valves (302) for switching the samples were analyzed by gas NO or the filter (306) filtering the zero gas.
2. 如权利要求1所述的装置,其特征在于:受试者口含与口呼采样模块(100)连接好的呼气过滤器,同时一个鼻孔通过鼻呼过滤器与鼻呼采样模块(200)连接好;受试者开始呼气后,压力传感器(105)会实时监测口呼压力,流量调节器(101)控制呼气流速在要求的范围内,当监测到有压力信号时,两通阀(104)开启,口呼气进入缓冲室一(103),需要排空的口呼气从两通阀(104)后端排出,符合要求的口呼气样本保留在缓冲室一(103)中;当口呼压力满足>5cmH 20时,采样栗(203)自动开启,驱动鼻腔气体进入缓冲室二(202),需要排空的鼻呼气从采样栗(203)后端排出,符合要求的比呼气样本保留在缓冲室二(202)中;当口呼气采样满足要求后,两通阀(104)关闭,呼气停止后,压力传感器监测到压力为0,采样栗(203)收到信号自动关闭,停止鼻呼气采样。 2. The apparatus according to claim 1, wherein: the subject buccal ligated exhalation port and exhalation filter sampling module (100), while a call through the nose nostril and nasal respiratory filter sampling module ( 200) connected; when a subject starts after exhalation, the pressure sensor (105) real time monitoring of a spoken pressure, flow regulator (101) controls the expiratory flow in the required range, when the monitored pressure signal, two valve (104) is turned into the buffer chamber an exhalation port (103), the need to empty from the discharge port two-way exhalation valve (104) rear, to meet the requirements port breath sample chamber retained in a buffer (103 ); and when the pressure satisfies a spoken> 5cmH 20, the sampling chestnut (203) automatically turns on, driving gas into the buffer chamber two nose (202), nasal exhalation need to empty (203) is discharged from the rear end of the sampling Li, to meet the requirements retention ratio in the second breath sample (202) in the buffer chamber; breath sampling port when meet the requirements, two-way valve (104) is closed, exhale stopped, the pressure sensor detects a pressure of 0, Li samples (203) received signal to automatically shut down to stop the nasal breath sampling.
3. 如权利要求1所述的装置,其特征在于:所述流量传感器(201)监测整个鼻呼采样过程的流量,实时反馈和调整采样栗控制参数,维持采样流速恒定。 3. The apparatus according to claim 1, wherein: the flow sensor (201) monitoring the call traffic across the nasal sampling process, real-time feedback and adjustment of the control parameters Li sample, the sample flow rate is maintained constant.
4. 如权利要求1所述的装置,其特征在于:在样本分析阶段,装置会自动开启分析栗(202),缓冲室一(103)中的口呼气样本被驱动经过三通阀一(301)、三通阀二(302)、湿度调节器(203)后进入NO传感器(204);缓冲室一(103)中的口呼气样本分析完成后,开启三通阀一(301),分析缓冲室二(202)中的鼻呼气样本,分析完成后,开启三通阀二(302),分析经过NO过滤器(306)过滤后的零点气;通过计算三段电流值就可以得到口呼气与鼻呼气的NO浓度。 4. The apparatus according to claim 1, wherein: the sample in the analysis phase, the device will automatically turn the analyte Li (202), the breath sample port a buffer chamber (103) is driven through a three-way valve ( 301), two three-way valve (302), a humidity regulator (after 203) into the NO sensor (204); in a buffer chamber (103) opening the breath sample analysis is completed, a three-way valve opening (301), analysis of breath samples two nasal buffer chamber (202), after analysis, open two-way valve (302), through the analysis of NO zero gas filter (306) filters; three sections by calculating the current value can be obtained oral exhalation breath nasal NO concentration.
5. -种对口与鼻呼气同时采样的装置由口呼采样模块(100)、鼻呼采样模块(200)与采样气袋一(501)、采样气袋二(502)构成,其特征在于: 所述口呼采样模块(100)由流量调节器(101)和三通阀一(106)串联组成,气路中连接有压力传感器(105),其中三通阀一(106)用于切换采样气排空或进入采样气袋一(501); 所述鼻呼采样模块(200)由流量传感器(201)、采样栗(203)和三通阀二(205)串联组成,其中三通阀二(205)用于切换采样气排空或进入采样气袋二(502)。 5. - nasal exhalation species counterparts means simultaneously sampled by a spoken sampling module (100), nasal respiratory sampling module (200) with a sampling bag (501), two sampling bag (502), and wherein : call the port sampling module (100) by a flow regulator (101) and a three-way valve (106) in series, the gas passage connecting a pressure sensor (105), wherein a three-way valve (106) for switching into the evacuated gas sampling or a sampling bag (501); the call nasal sampling module (200) by the flow rate sensor (201), Li samples (203) and two three-way valve (205) connected in series, wherein three-way valve two (205) for switching the evacuated gas sampling bag or into two samples (502).
6. 如权利要求5所述的装置,其特征在于:受试者口含与口呼采样模块(100)连接好的呼气过滤器,同时一个鼻孔通过鼻呼过滤器与鼻呼采样模块(200)连接好;受试者开始呼气后,压力传感器(105)会实时监测口呼压力,流量调节器(101)控制呼气流速在要求的范围内,切换三通阀一(106)按要求进行排空后,符合要求的口呼气样本采集到采样气袋一(501)中;当口呼压力满足>5cmH 20时,采样栗(203)自动开启,驱动鼻腔气体进入鼻呼采样模块(200),切换三通阀二(205)按要求进行排空后,符合要求的鼻呼气样本采集到采样气袋二(502)中;当口呼气采样满足要求后,提示采样成功,呼气停止后,压力传感器监测到压力为〇,采样栗(203)收到信号自动关闭,停止鼻呼气采样。 6. The apparatus according to claim 5, characterized in that: the subject buccal ligated exhalation port and exhalation filter sampling module (100), while a call through the nose nostril and nasal respiratory filter sampling module ( 200) connected; subject starts after exhalation, the pressure sensor (105) real time monitoring of a spoken pressure, flow regulator (101) controlling expiratory flow rate in the range of claims, a switching three-way valve (106) by after the emptying required, to meet the requirements of the breath sample collection port into a sampling bag (501); when the pressure satisfies a spoken> 5cmH 20, the sampling chestnut (203) automatically turns on, driving gas into the nasal cavity the nasal respiratory sampling module ( after 200), two switching three-way valve (205) is emptied as required, to meet the requirements of the nasal breath sample collection bag to the two samples (502); when the breath sampling port to meet the requirements, a successful prompt sample, expiration after stopping, the pressure sensor detects a pressure square, Li sampling (203) the received signal automatically closed to stop the nasal breath sampling.
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