CN106248418B - Biological sample cutting machine and biological sample cutting method - Google Patents
Biological sample cutting machine and biological sample cutting method Download PDFInfo
- Publication number
- CN106248418B CN106248418B CN201610339504.5A CN201610339504A CN106248418B CN 106248418 B CN106248418 B CN 106248418B CN 201610339504 A CN201610339504 A CN 201610339504A CN 106248418 B CN106248418 B CN 106248418B
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- biological sample
- dictyosome
- segmentation
- microscope carrier
- rotation
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- 239000012472 biological sample Substances 0.000 title claims abstract description 150
- 238000000034 method Methods 0.000 title claims abstract description 18
- 239000012634 fragment Substances 0.000 claims abstract description 19
- 230000011218 segmentation Effects 0.000 claims description 77
- 239000000523 sample Substances 0.000 claims description 18
- 238000002347 injection Methods 0.000 claims description 17
- 239000007924 injection Substances 0.000 claims description 17
- 238000007599 discharging Methods 0.000 claims description 14
- 239000007788 liquid Substances 0.000 claims description 14
- 239000007921 spray Substances 0.000 claims description 12
- 230000001050 lubricating effect Effects 0.000 claims description 11
- 239000012530 fluid Substances 0.000 claims description 10
- 239000007789 gas Substances 0.000 description 9
- 210000001519 tissue Anatomy 0.000 description 6
- 238000001514 detection method Methods 0.000 description 4
- 239000000463 material Substances 0.000 description 4
- 230000000694 effects Effects 0.000 description 3
- 239000000243 solution Substances 0.000 description 3
- XKRFYHLGVUSROY-UHFFFAOYSA-N Argon Chemical compound [Ar] XKRFYHLGVUSROY-UHFFFAOYSA-N 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- BASFCYQUMIYNBI-UHFFFAOYSA-N platinum Chemical compound [Pt] BASFCYQUMIYNBI-UHFFFAOYSA-N 0.000 description 2
- 230000003068 static effect Effects 0.000 description 2
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 1
- 229910000881 Cu alloy Inorganic materials 0.000 description 1
- 229910001021 Ferroalloy Inorganic materials 0.000 description 1
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 1
- 239000000956 alloy Substances 0.000 description 1
- 229910052786 argon Inorganic materials 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 230000018109 developmental process Effects 0.000 description 1
- 229910003460 diamond Inorganic materials 0.000 description 1
- 239000010432 diamond Substances 0.000 description 1
- 229910001873 dinitrogen Inorganic materials 0.000 description 1
- 239000000644 isotonic solution Substances 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 239000007769 metal material Substances 0.000 description 1
- 229910052697 platinum Inorganic materials 0.000 description 1
- 210000004872 soft tissue Anatomy 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 238000000638 solvent extraction Methods 0.000 description 1
- 239000010935 stainless steel Substances 0.000 description 1
- 229910001220 stainless steel Inorganic materials 0.000 description 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N1/00—Sampling; Preparing specimens for investigation
- G01N1/02—Devices for withdrawing samples
- G01N1/04—Devices for withdrawing samples in the solid state, e.g. by cutting
Abstract
The invention provides a biological sample divider and a biological sample dividing method, wherein the biological sample divider comprises a dividing net body and a rotary carrying platform; the split net body is encircled to form an accommodating space; the rotating carrier is arranged in the accommodating space and provided with a bearing surface used for bearing at least one biological sample, and when the rotating carrier rotates relative to the cutting net body, the rotating carrier can drive the biological sample to throw towards the cutting net body so as to enable the cutting net body to cut the biological sample into a plurality of biological sample fragments. According to the biological sample cutting machine and the biological sample cutting method, when the rotary carrying platform rotates relative to the cutting net body, the rotary carrying platform drives the biological sample to throw towards the cutting net body, the cutting net body cuts the biological sample into a plurality of biological sample fragments with the same size as the mesh size of the cutting net body, and the problems that in the prior art, small-size biological samples generated by manually cutting the biological samples are not easy to fix and cut, and the size errors among the obtained samples are large are solved.
Description
Technical field
The present invention relates to machinery field more particularly to a kind of automated biological sample segment machine and automated biological sample segment sides
Method.
Background technique
With the fast development of biotechnology, various tissue cultures and Measurement for Biotechnique and analytical equipment, which allow, studies people
Member can deeper into discussion biology secret.After researcher obtains biological sample, in order to carry out different detection project or
It is to carry out tissue cultures, needs for the original biological specimen of acquirement to be divided into the lesser biological sample of size, then size is smaller
Biological sample merging analytical equipment in analyzed, or merging culture dish or culture tank in carry out tissue cultures.
Biological sample partitioning scheme in currently known technology is that researcher on the other hand first fixes biological sample, the other hand
Blade is held again and directly divides biological sample, to obtain the biological sample that size meets detection demand or tissue cultures demand.So
And above-mentioned cutting mode will face the problem of sample is not fixed easily and the problem that sample segment precision is difficult to control.
Summary of the invention
Technical problem to be solved by the present invention lies in provide a kind of biological sample separate machine in view of the deficiencies of the prior art
With biological sample dividing method, to solve small size biological sample caused by manual cutting biological sample in the prior art not
It is fixed easily and is not easy to cut, and the larger problem of scale error between obtained sample.
The technical problem to be solved by the present invention is to what is be achieved through the following technical solutions:
A kind of biological sample separate machine, including a segmentation dictyosome and a rotation microscope carrier；It is empty around an accommodating is gone out to divide dictyosome
Between；Rotation microscope carrier is set in the accommodating space, and rotation microscope carrier has a loading end, and loading end is to carry at least one biology
Sample, when rotating the rotation of microscope carrier opposite segment dictyosome, rotation microscope carrier drives biological sample to get rid of to segmentation dictyosome, to enable segmentation net
Biological sample is divided into multiple biological sample fragments by body.
It preferably, further include a rotation drive device, the rotation drive device has a rotary shaft, and the rotary shaft connects
The rotation microscope carrier is connect, the rotation drive device is to drive the rotation microscope carrier to rotate relative to the segmentation dictyosome.
It preferably, further include a collector, the collector rings are around the segmentation dictyosome, and the collector is close to described
The side for dividing dictyosome has a collecting tank, and the collector is to collect the biological sample fragment across the segmentation dictyosome.
It preferably, further include an air injection equipment, the air injection equipment has an at least puff prot, at least one puff prot
The segmentation dictyosome is directed at close to the side of the rotation microscope carrier, at least one puff prot is to spray a gas to increase to
A few biological sample compresses the strength of the segmentation dictyosome.
It preferably, further include a liquid discharging device using it, the liquid discharging device using it has an at least mouth spray, and at least one hydrojet
Mouth is directed at the loading end, and the liquid discharging device using it is sprayed onto the loading end from least one mouth spray with a lubricating fluid, with drop
The coefficient of friction of the low loading end.
Preferably, the loading end has multiple projective structures, and multiple projective structures are to increase the loading end
Coefficient of friction.
Preferably, the thickness in the rotation microscope carrier center is less than the thickness of periphery.
Preferably, the radius of the rotation microscope carrier is 5 centimetres -30 centimetres.
Preferably, it is described rotation microscope carrier relative to it is described segmentation dictyosome rotation tachometer value be 1000 revs/min -20000 turns/
Minute.
Preferably, the mesh size of the segmentation dictyosome is 0.1 square centimeter -1 square centimeter.
Preferably, a distance is kept between the segmentation dictyosome and the rotation microscope carrier, the distance is greater than biological sample
Side length.
The present invention also provides a kind of biological sample dividing methods, including at least all one's life object sample is placed in a rotation microscope carrier
One loading end；Driving rotation microscope carrier drives the opposite segmentation dictyosome for revolving around it microscope carrier of an at least biological sample to rotate, make to
A few biological sample is thrown toward segmentation dictyosome and is divided dictyosome and is divided into multiple biological sample fragments.
It preferably, further include that the biology across the segmentation dictyosome is collected using the collector around the segmentation dictyosome
Sample fragment makes biological sample fragment fall within the collector in a collecting tank of the side of the segmentation dictyosome.
It preferably, further include that one gas is sprayed to increase at least all one's life object to an at least biological sample using an air injection equipment
Sample compresses the strength of the segmentation dictyosome.
It preferably, further include being rubbed using a liquid discharging device using it to loading end sprinkling lubricating fluid with reducing the loading end
Wipe coefficient.
Preferably, the rotation microscope carrier is 1000 rev/min -20000 relative to the tachometer value of the segmentation dictyosome rotation
Rev/min.
The biological sample separate machine and biological sample dividing method provided according to the present invention, when rotation microscope carrier opposite segment net
When body rotates, rotation microscope carrier will drive biological sample and get rid of to segmentation dictyosome, to enable segmentation dictyosome that biological sample is divided into size
Multiple biological sample fragments identical with segmentation dictyosome mesh size, solve produced by manual cutting biological sample in the prior art
Small size biological sample be not fixed easily and be not easy to cut, and the larger problem of scale error between obtained sample.
The explanation of explanation and specific embodiment below above with respect to present invention content be to demonstrate with
It explains spirit and principle of the invention, and the claims in the present invention is provided and are further explained.
Detailed description of the invention
Fig. 1 is the biological sample separate machine stereochemical structure partial sectional view of the embodiment of the present invention one；
Fig. 2 is the biological sample separate machine cross-sectional view of the embodiment of the present invention one；
Fig. 3 is the biological sample separate machine cross-sectional view of the embodiment of the present invention two；
Fig. 4 is the biological sample separate machine cross-sectional view of the embodiment of the present invention three.
[attached body description of symbols]
100,200,300 biological sample separate machine
110 segmentation dictyosomes
111 accommodating spaces
112 first openings
113 second openings
114 meshes
120,220,320 rotation microscope carrier
121,221,321 loading end
2211 projective structures
130 rotation drive devices
131 rotary shafts
140 collectors
141 collect wall surface
142 projective structures
143 collecting tanks
150 air injection equipments
151 puff prots
160 liquid discharging device using its
161 mouth sprays
S biological sample
S ' biological sample fragment
Specific embodiment
Describe detailed features and advantage of the invention in detail in embodiments below, content is enough to keep this field general
Logical technical staff understands technology contents of the invention and implements accordingly, and content, claim according to documented by this specification
Protection scope and attached drawing, those of ordinary skill in the art can be readily understood upon the object of the invention and beneficial effect.Implementation below
The example viewpoint that present invention be described in more detail, but the non-scope anyways to limit the claims in the present invention protection.
Embodiment one
Fig. 1 is the biological sample separate machine stereochemical structure partial sectional view of the embodiment of the present invention one, and Fig. 2 is that the present invention is implemented
The biological sample separate machine cross-sectional view of example one, as shown in Figures 1 and 2, the biological sample separate machine 100 of the embodiment of the present invention one wrap
Include a segmentation dictyosome 110, one rotation microscope carrier 120, a rotation drive device 130, a collector 140, an air injection equipment 150 and one
Liquid discharging device using it 160.Divide dictyosome 110 around go out an accommodating space 111, and be located at accommodating space 111 with respect to two sides and with appearance
111 one first opening 112 and one second opening 113 being connected between emptying.In the embodiment of the present invention one, divide dictyosome 110
For the hollow columnar structures of two side openings, but not limited to this.In other embodiments of the present invention, segmentation dictyosome also can be opening
Hollow columnar structures in side.Dividing dictyosome 110 has multiple meshes 114.In the embodiment of the present invention one, mesh 114
Size is 0.1 square centimeter -1 square centimeter, and but not limited to this.In other embodiments of the present invention, the size of mesh can be
0.3 square centimeter -0.8 square centimeter, it is preferable that mesh size is 0.4 square centimeter -0.6 square centimeter.Implement in the present invention
In example one, the shape of mesh is quadrangle, and but not limited to this.In other embodiments of the present invention, the shape of mesh can be
Round, rectangle or diamond shape.
Rotation microscope carrier 120 can opposite segment dictyosome 110 be rotatably provided in accommodating space 112.Rotate the rotation of microscope carrier 120
Turn the first opening 112 for being axially parallel to segmentation dictyosome 110 and the second 113 line directions of opening.Rotating microscope carrier 120 has direction
Divide a loading end 121 of the first opening 112 of dictyosome 110.Loading end 121 provides biology to carry a biological sample S
Sample S is detached from the centrifugal force of the loading end 121 of rotation microscope carrier 120.In the embodiment of the present invention one, biological sample S is fatty group
It knits, but not limited to this.In other embodiments of the present invention, biological sample can be musculature or other soft tissues.At this
In inventive embodiments one, the biological sample S quantity that loading end 121 carries is one, and but not limited to this.In other realities of the invention
It applies in example, loading end can carry more than one biological sample simultaneously.
Loading end 121 is, for example, the plane of a smooth planar and has low-friction coefficient.In the embodiment of the present invention one,
The radius of loading end 121 is 5 centimetres -30 centimetres, and but not limited to this.In other embodiments of the present invention, the radius of loading end
It is 10 centimetres -25 centimetres, it is preferable that the radius of loading end is 15 centimetres -20 centimetres.In the embodiment of the present invention one, loading end
121 with segmentation dictyosome 110 material be stainless steel, but not limited to this.In other embodiments of the present invention, loading end and segmentation
Dictyosome can be different materials, and material can be metal material or alloy material, such as: platinum, copper alloy or ferroalloy.It holds
There is a first distance d between section 121 and the first opening 112 for dividing dictyosome 1101.First distance d1Greater than biological sample S
Maximal side, flown out by the first opening 112 after being detached from carrying tablet 121 to avoid biological sample S and divided dictyosome 110.Rotation carries
The edge and segmentation dictyosome of platform 120 keep a distance, this distance is greater than the maximal side of biological sample S, to ensure biological sample S
Rotation microscope carrier 120 can be completely disengaged when hitting segmentation dictyosome 110, and then promotes segmentation dictyosome 110 for point of biological sample S
Cut effect.
Rotation drive device 130 is, for example, a motor, has a rotary shaft 131.Rotary shaft 131 passes through segmentation dictyosome 110
Second opening 113 and connect rotation microscope carrier 120.Rotation drive device 130 passes through driving rotation 120 phase of microscope carrier of rotary shaft 131
Segmentation dictyosome 110 is rotated, and the tachometer value of driving rotation 120 opposite segment dictyosome 110 of the microscope carrier rotation of rotation drive device 130
It is adjustable.In the embodiment of the present invention one, rotation 120 opposite segment dictyosome 110 of microscope carrier rotation tachometer value be 1000 turns/
- 20000 rev/min per minute, but not limited to this.In other embodiments of the present invention, microscope carrier opposite segment dictyosome is rotated
The tachometer value of rotation is -15000 rev/min of 3000 rev/min, it is preferable that rotation microscope carrier opposite segment dictyosome rotation
Tachometer value is -10000 rev/min of 5000 rev/min.In the embodiment of the present invention one, 120 opposite segment net of microscope carrier is rotated
The tachometer value that body 110 rotates be it is adjustable, but not limited to this, in other embodiments of the present invention, opposite point of rotation microscope carrier
The tachometer value for cutting dictyosome rotation also can be fixed.
Collector 140 is around segmentation dictyosome 110, such as can be but be not limited to hollow columnar knot made of being surrounded as sheet material
Structure.The side of collector 140 towards segmentation dictyosome 110 has one to collect wall surface 141 and a projective structure 142.Projective structure
A collecting tank 143 is collectively formed in 142 prominent collection wall surfaces 141, projective structure 142 and collection wall surface 141.Collecting tank 143 is for example
For a trench collecting tank.Collecting tank 143 is located at the extension line of the first opening 112 and the prolonging for the second opening 113 of segmentation dictyosome 110
It stretches between line.There is a second distance d between the extension line of first opening 112 of collecting tank 143 and segmentation dictyosome 1102, and the
Two distance d2Greater than first distance d1.It is formed in this way, which the biological sample S for being detached from loading end 121 is divided the cutting of dictyosome 110
Biological sample fragment S ' and by the way that after mesh 114, the collection wall surface 141 of impact collector 140 is sliding further along wall surface 141 is collected
Enter in collecting tank 143.
Air injection equipment 150 has a puff prot 151.The alignment of puff prot 151 segmentation dictyosome 110 is close to rotation microscope carrier 120
Side.Air injection equipment 150 can by puff prot 151 towards be attached to segmentation dictyosome 110 close to rotation 120 side of microscope carrier biological sample
Product S sprays high pressure gas.High pressure gas increases the strength that biological sample S compresses segmentation dictyosome 110, and biological sample S is assisted to be divided
Dictyosome 110 is cut to divide and by the mesh 114 of segmentation dictyosome 110.In the embodiment of the present invention one, the type of high pressure gas is nitrogen
Gas, but not limited to this.In other embodiments of the present invention, high pressure gas can also be air, argon gas or other gases.At this
In inventive embodiments one, the quantity of the puff prot 151 of air injection equipment 150 is one, and but not limited to this.In other realities of the invention
It applies in example, the quantity of puff prot can be that can also be not provided with air injection equipment greater than one.In other embodiments of the present invention,
Air injection equipment may also include an elastic tube body, so that user moves the life that puff prot is attached to segmentation dictyosome with close and alignment
Object sample.
Liquid discharging device using it 160 has a mouth spray 161.The loading end 121 of the alignment rotation microscope carrier 120 of mouth spray 161, for example, it is right
The central area of quasi- loading end 121.Liquid discharging device using it 160 can be before biological sample S be placed in loading end 121, by mouth spray 161
Lubricating fluid is sprayed towards loading end 121, so that lubricating fluid covers loading end 121 and reduces the coefficient of friction of loading end 121.Work as life
When object sample S is not easily shifted with strong viscosity or is thrown out of loading end 121, lubricating fluid is sprayed to loading end 121 in advance
It may make that loading end 121 and the contact surface of biological sample S are lubricated, and then make side of the biological sample S quickly toward loading end 121
Edge slides and is thrown out of loading end 121.In the embodiment of the present invention one, lubricating fluid is culture solution, and but not limited to this.In this hair
In bright other embodiments, lubricating fluid can also be the isotonic solution of normal saline solution or other biological sample.
When executing biological sample dividing method of the invention using biological sample separate machine of the invention, user is by dividing
Biological sample S is placed in the loading end 121 of rotation microscope carrier 120 by the first opening 112 of dictyosome 110.Place the position of biological sample S
It can be the central area of loading end 121, can also be the fringe region of loading end 121.At this point, rotation microscope carrier 120 can be located
In the state that opposite segment dictyosome 110 rotates, static state can also be in.If rotation microscope carrier 120 is in opposite segment net
The static state of body 110 then makes to rotate the beginning rotation of opposite segment dictyosome 110 of microscope carrier 120.Then, positioned at the life of loading end 121
Object sample S is as loading end opposite segment dictyosome 110 rotates and is acted on gradually by centrifugal force toward the direction at 121 edge of loading end
It is mobile.Once biological sample S is detached from 121 edge of loading end, biological sample S is got rid of to by centrifugal force and hits segmentation dictyosome 110.?
While biological sample S hits segmentation dictyosome 110, biological sample S bears segmentation 110 pressure applied of dictyosome and is divided into
Biological sample fragment S ', and the mesh 114 for passing through segmentation dictyosome 110 is mobile toward collector 140.Biological sample fragment S ' is hit
After the collection wall surface 141 of collector 140, slid into collecting tank 143 along wall surface 141 is collected.Finally, user is by collecting tank
Biological sample fragment S ' is collected in 143 to carry out subsequent biology sample detection or tissue cultures.
When executing biological sample dividing method of the invention using biological sample separate machine of the invention, can further make
Gas is sprayed to biological sample S with air injection equipment 150, increases the strength that biological sample S compresses segmentation dictyosome 110 whereby, in turn
Promote the efficiency of segmentation biological sample S.Furthermore biological sample of the invention point is executed using biological sample separate machine of the invention
When segmentation method, it can also further use liquid discharging device using it 160 and lubricating fluid is sprayed to loading end 121, whereby lubricating bearing face 121 and life
The contact surface of object sample S, and then make biological sample S quickly toward the boundary slip of loading end 121 and be thrown out of loading end 121.
In addition, the segmentation dictyosome 110 of the biological sample separate machine 100 of the embodiment of the present invention one is replaceable.User can
According to biology sample detection or the size requirements of tissue cultures, select have the segmentation dictyosome 110 of appropriate 114 size of mesh with
Obtain the biological sample fragment S ' for meeting size requirements.
In addition, the biological sample separate machine 100 of the embodiment of the present invention one further includes a fixed frame (not shown), with solid
Surely the relative position between dividing dictyosome 110, collector 140, air injection equipment 150 and liquid discharging device using it 160 and maintaining, but not
As limit.In other embodiments of the present invention, divide dictyosome 110, collector 140, air injection equipment 150 and liquid discharging device using it 160
Also it may be disposed among a shell and be individually fixed in the inner wall of shell.
Embodiment two
Fig. 3 is the biological sample separate machine cross-sectional view of the embodiment of the present invention two, as shown in figure 3, two-phase of the embodiment of the present invention
It is similar to embodiment one, is illustrated below only for difference, something in common just repeats no more herein.
In the biological sample separate machine 200 of the embodiment of the present invention two, the loading end 221 of rotation microscope carrier 220 has multiple convex
Structure 2211 out.Multiple projective structures 2211 can increase the frictional force between biological sample S and loading end 221, extend biological sample
The time that product S is rotated with loading end 221, so that biological sample S bears biggish centrifugal force and have when being detached from loading end 221
Biggish speed.In this way, which preferable cutting effect can be obtained when hitting segmentation dictyosome in biological sample S.Implement in the present invention
In example two, projective structure 2211 is annular projection, and but not limited to this.In other embodiments of the present invention, projective structure can be with
For columnar projections.
Embodiment three
Fig. 4 is the biological sample separate machine cross-sectional view of the embodiment of the present invention three, as shown in figure 4, three-phase of the embodiment of the present invention
It is similar to embodiment one, is illustrated below only for difference, something in common just repeats no more herein.
In the biological sample separate machine 300 of the embodiment of the present invention three, the central area thickness of rotation microscope carrier 320 is less than edge
Area thickness, so that loading end 321 is disc-shaped.Disc-shaped loading end 321 makes centrifugal force only have the center by rotation microscope carrier 320
The component in region points toward edge region can drive biological sample S mobile toward the direction for being detached from loading end, extend biological sample S with
The time that loading end 321 rotates, so that biological sample S has biggish speed when being detached from loading end 321.In this way,
Preferable cutting effect can be obtained when hitting segmentation dictyosome in biological sample S.
The biological sample separate machine and biological sample dividing method recorded according to the present invention, when rotation microscope carrier opposite segment net
When body rotates, rotation microscope carrier will drive biological sample and get rid of to segmentation dictyosome, to enable segmentation dictyosome that biological sample is divided into size
Multiple biological sample fragments identical with segmentation dictyosome mesh size, solve produced by manual cutting biological sample in the prior art
Small size biological sample be not fixed easily and be not easy to cut, and the larger problem of scale error between obtained sample.
Claims (14)
1. a kind of biological sample separate machine characterized by comprising
One segmentation dictyosome, the segmentation dictyosome is around an accommodating space out；And
One rotation microscope carrier, is set in the accommodating space, the rotation microscope carrier has a loading end, and the loading end is to hold
It is loaded onto a few biological sample, when the rotation microscope carrier is rotated relative to the segmentation dictyosome, the rotation microscope carrier drives at least one
The biological sample is got rid of to the segmentation dictyosome, so that at least one biological sample is divided into multiple lifes by the segmentation dictyosome
Object sample fragment；
Wherein, the biological sample separate machine further includes an air injection equipment, and the air injection equipment has an at least puff prot, until
A few puff prot is directed at the segmentation dictyosome close to the side of the rotation microscope carrier, and at least one puff prot is to spray
One gas is to increase the strength that at least one biological sample compresses the segmentation dictyosome.
2. biological sample separate machine as described in claim 1, which is characterized in that further include a rotation drive device, the rotation
Rotary driving device has a rotary shaft, rotates microscope carrier described in the rotation axis connection, the rotation drive device is to drive
Rotation microscope carrier is stated to rotate relative to the segmentation dictyosome.
3. biological sample separate machine as described in claim 1, which is characterized in that further include a collector, the collector rings
Around the segmentation dictyosome, and the collector has a collecting tank close to the side of the segmentation dictyosome, the collector to
Collect multiple biological sample fragments across the segmentation dictyosome.
4. biological sample separate machine as described in claim 1, which is characterized in that further include a liquid discharging device using it, the hydrojet is set
Standby have an at least mouth spray, and at least one mouth spray is directed at the loading end, the liquid discharging device using it with a lubricating fluid oneself
At least one mouth spray is sprayed onto the loading end, to reduce the coefficient of friction of the loading end.
5. biological sample separate machine as described in claim 1, which is characterized in that the loading end has multiple projective structures,
Coefficient of friction of multiple projective structures to increase the loading end.
6. biological sample separate machine as described in claim 1, which is characterized in that the thickness in the rotation microscope carrier center is less than outer
The thickness enclosed.
7. biological sample separate machine as described in claim 1, which is characterized in that the radius of the rotation microscope carrier is 5 centimetre -30
Centimetre.
8. biological sample separate machine as described in claim 1, which is characterized in that the relatively described segmentation dictyosome of rotation microscope carrier
The tachometer value of rotation is 1000 revs/min -20000 revs/min.
9. biological sample separate machine as described in claim 1, which is characterized in that the mesh size of the segmentation dictyosome is 0.1
- 1 square centimeter of square centimeter.
10. biological sample separate machine as described in claim 1, which is characterized in that the segmentation dictyosome and the rotation microscope carrier
Edge keep a distance, the distance be greater than biological sample maximal side.
11. a kind of biological sample dividing method characterized by comprising
At least all one's life object sample is placed in a loading end of a rotation microscope carrier；And
The rotation microscope carrier is driven to drive at least one biological sample relative to the segmentation dictyosome rotation around the rotation microscope carrier
Turn, at least one biological sample is made to be thrown toward the segmentation dictyosome and be divided into multiple biological samples broken by the segmentation dictyosome
Piece；
Wherein, the biological sample dividing method further includes using an air injection equipment at least one biological sample injection one
Gas is to increase the strength that at least one biological sample compresses the segmentation dictyosome.
12. biological sample dividing method as claimed in claim 11, which is characterized in that further include using around the segmentation net
One collector of body collects the biological sample fragment across the segmentation dictyosome, so that biological sample fragment is fallen within the collector and leans on
In one collecting tank of the side of the nearly segmentation dictyosome.
13. biological sample dividing method as claimed in claim 11, which is characterized in that further include using a liquid discharging device using it to institute
Loading end sprinkling lubricating fluid is stated to reduce the coefficient of friction of the loading end.
14. biological sample dividing method as claimed in claim 11, which is characterized in that the relatively described segmentation of rotation microscope carrier
The tachometer value of dictyosome rotation is -20000 rev/min of 1000 rev/min.
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| TW104209293 | 2015-06-10 | ||
| TW104209293 | 2015-06-10 | ||
| TW104141827 | 2015-12-11 | ||
| TW104141827A TWI576154B (en) | 2015-06-10 | 2015-12-11 | Biological sample divider and biological sample dividing method |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN106248418A CN106248418A (en) | 2016-12-21 |
| CN106248418B true CN106248418B (en) | 2019-05-07 |
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| CN201610339504.5A Active CN106248418B (en) | 2015-06-10 | 2016-05-20 | Biological sample cutting machine and biological sample cutting method |
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| EP1626844B1 (en) * | 2003-05-29 | 2013-05-08 | Urschel Laboratories, Inc. | Cutting head for cutting a food product |
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| CN106248418A (en) | 2016-12-21 |
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