CN106236607A - A kind of on-aqueous liquid combination medicament for planting tooth later stage toothcare - Google Patents
A kind of on-aqueous liquid combination medicament for planting tooth later stage toothcare Download PDFInfo
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- CN106236607A CN106236607A CN201610636487.1A CN201610636487A CN106236607A CN 106236607 A CN106236607 A CN 106236607A CN 201610636487 A CN201610636487 A CN 201610636487A CN 106236607 A CN106236607 A CN 106236607A
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- anhydrous
- tooth
- aqueous liquid
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/22—Peroxides; Oxygen; Ozone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/36—Carboxylic acids; Salts or anhydrides thereof
- A61K8/361—Carboxylic acids having more than seven carbon atoms in an unbroken chain; Salts or anhydrides thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/81—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions involving only carbon-to-carbon unsaturated bonds
- A61K8/8135—Compositions of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by an acyloxy radical of a saturated carboxylic acid, of carbonic acid or of a haloformic acid; Compositions of derivatives of such polymers, e.g. vinyl esters (polyvinylacetate)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/81—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions involving only carbon-to-carbon unsaturated bonds
- A61K8/8141—Compositions of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by only one carboxyl radical, or of salts, anhydrides, esters, amides, imides or nitriles thereof; Compositions of derivatives of such polymers
- A61K8/8147—Homopolymers or copolymers of acids; Metal or ammonium salts thereof, e.g. crotonic acid, (meth)acrylic acid; Compositions of derivatives of such polymers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/81—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions involving only carbon-to-carbon unsaturated bonds
- A61K8/817—Compositions of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by a single or double bond to nitrogen or by a heterocyclic ring containing nitrogen; Compositions or derivatives of such polymers, e.g. vinylimidazol, vinylcaprolactame, allylamines (Polyquaternium 6)
- A61K8/8176—Homopolymers of N-vinyl-pyrrolidones. Compositions of derivatives of such polymers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/84—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
- A61K8/86—Polyethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
- A61Q11/02—Preparations for deodorising, bleaching or disinfecting dentures
Abstract
The invention discloses a kind of on-aqueous liquid combination medicament for planting tooth later stage toothcare, the stable non-aqueous liquid tooth whitening composition that scattered anhydrous peroxide compound in mixture forms is can accept by the oral cavity at anhydrous hydrophilic polymer and adhesiving reinforcing agent, said composition forms the adhesion coating comprising peroxide compound when being applied topically on dental surface, and this peroxide compound discharges from layer to carry out teeth whitening thereafter.
Description
Technical field
The present invention relates to dental implant later maintenance field, more particularly to one be used for planting tooth later stage tooth dimension
The on-aqueous liquid combination medicament protected.
Background technology
Tooth is made up of internal dentin layer and outer hard enamel layer, and adamantine layer is the protective layer of tooth.Tooth
Adamantine layer is nature opaque white color or the most linen.Adamantine layer can be colored or variable color.The enamel of tooth
Layer is made up of hydroxyapatite mineral crystals, and this crystal produces a certain degree of porous surface.These hydroxyapatite crystals form structure
Become microcosmic hexagonal bar or the prism of enamel surface.Result is the micro-space that the surface of adamantine layer is presented between prism
Or hole.It is believed that this porous character of adamantine layer allows stain and electrochromic substance infiltration enamel and makes tooth discoloration.These
Remaining material can occupy micro-space and finally change the color of tooth.
People every day in the face of or many materials of contact " can dye " or reduce " whiteness " of people's tooth.Especially, people
Food, tobacco product and the fluid consumed tends to the tooth of dyeing people.These products or material tend to the dentium nitor at tooth
Accumulate on matter layer and on tooth, form pellicle.These dyeing and the most permeable adamantine layers of electrochromic substance.This problem be by
Gradually occur within many years, but give the ground significant variable color of enamel of people's tooth.As long as the tooth of variable color is the most healthy
Not bringing any health risk or problem, the product or the material that are brightened by discored tooth will be favourable.
Particularly planting the tooth later stage, implanting tooth inhibited from yellowing, thus aberration impact can be occurred attractive in appearance.
The product and the material that are presently available for whitening teeth include various different composition, but main active component is to join
Make liquid, aqueous, solution, paste or the peroxide reagent of gel.Owing to peroxide compound in aqueous is phase
To instability, these products lose their effect in time when storage.This tendency limit instable to peroxide
Make the liquid, aqueous whitening products function for whitening teeth.Therefore it is highly desirable to provide stable peroxide whitening liquid
Brighten carrying out essence.
Summary of the invention
According to an aspect of the present invention, it is provided that a kind of on-aqueous liquid combination medicament for planting tooth later stage toothcare,
It is non-aqueous by stablizing of forming of anhydrous peroxide brightening agent anhydrous liquid suspension in anhydrous liquid hydrophilic polymer
Dental whitening compositions, this suspension is viscous enough to form the compositions containing peroxide at tooth when being applied to tooth
The pantostrat of the adhesion on tooth enamel surface.
For solving above-mentioned technical problem, the present invention by the following technical solutions:
A kind of on-aqueous liquid combination medicament for planting tooth later stage toothcare, it is characterised in that: anhydrous parent is can accept in oral cavity
Scattered anhydrous peroxide compound in waterborne polymeric and adhesiving reinforcing agent, said composition is when being applied topically to dental surface
Time formed and comprise the adhesion coating of peroxide compound, wherein said peroxide compound discharges from layer to carry out tooth subsequently
Brighten；Described anhydrous peroxide compound is SODIUM PERCARBONATE；Described anhydrous peroxide compound is PVP/H2O2；Anhydrous parent
Waterborne polymeric is liquid polymers；Anhydrous hydrophilic liquid polymer is Polyethylene Glycol；Described adhesiving reinforcing agent is acetic acid second
Enoate copolymer.
Further, the concentration that described PVP/H2O2 exists in the composition is 3wt%.
Further, the quantity that described SODIUM PERCARBONATE exists in the composition is about 55wt%.
Further, the quantity that described anhydrous liquid hydrophilic polymer exists in the composition is 90wt%.
Compared with prior art, the invention has the beneficial effects as follows: the anhydrous liquid hydrophilic polymer of the present invention provides steady
Fixed carrier, this carrier prevents during storing and the decomposition of non-peroxide whitening agent before the use.Once at dental surface
Upper applying, the saliva on the tooth enamel surface being applied with compositions is dissolved or the disintegrate layer containing peroxide, was caused
The fast decoupled of oxide, it transfers to provide whitening effect.
Detailed description of the invention
Below in conjunction with embodiment, the present invention is further illustrated.Embodiments of the present invention include but not limited to following
Embodiment.
The description of preferred embodiment
Term " hydrophilic " polymer used at this represents having of at 25 DEG C water solubility at least about one gram of every 100 grams of water
Machine polymer.Term " hydrophobicity " polymer used at this or " water-insoluble " polymer represent that water solubility is little at 25 DEG C
Organic polymer in about one gram of every 100 grams of water.Term "non-aqueous" as used herein represents and exists in the present compositions
Water less than 10wt%.
The compositions of the present invention is viscous suspension, and this suspension keeps its concordance during storing so that product
Can be brushed by soft applicator and on tooth surfaces or be applied by strip coatings.
Non-aqueous hydrophilic liquid polymer
The polymer being used as peroxide carrier according to the present invention is selected from water solublity and the liquid of water dispersible organic polymer
Hydrophilic polymer.Can use the mixture of polymer, and content be about the hydrophobic polymer of 1.0-50% can be with
Hydrophilic polymer is included in strengthening the adhesion property of liquid tooth whitening composition together.
Non-aqueous hydrophilic polymer for present invention practice is preferably compositions provides about 10,000cps to 600,
The viscosity of 000cps.
Be applicable to the example of on-aqueous liquid hydrophilic polymer carrier of present invention practice include Polyethylene Glycol, have as follows
The non-ionic polymers of the oxirane of formula:
HOCH2 (CH2OCH2) nOH wherein n represents the average number that oxyethylene group is rolled into a ball.Polyethylene Glycol purchased from Dow Chemical
Being indicated by numeral such as 200,300,400,600,2000, they represent the approximation mean molecule quantity of polymer.Polyethylene glycol 200,
300,400 and 600 is at room temperature transparent viscous liquid, and is preferred for the practice of the present invention.
For preparing the second of the present composition preferred on-aqueous liquid hydrophilic polymer by the epoxy second of following formula
The water-soluble nonionic block copolymer composition of alkane and expoxy propane:
HO(C2H4O)a(C3H6O)b(C2H4O)cH
Preferably select this copolymer molecule about 65-that block copolymer (about a, b and c) makes ethylene oxide constituent constitute about
75wt%, and the mean molecule quantity of copolymer is about 2, and 000-about 15,000, copolymer is in liquid tooth whitening composition
The concentration existed makes compositions for liquid under room temperature (23 DEG C).
The block copolymer needed especially for present invention practice purchased from BASF and is denoted as Pluraflo L1220, it
Mean molecule quantity be about 9,800.Hydrophilic poly-(oxirane) block is averagely about the polymer of 65wt%.
Typically, the quantity existed for the on-aqueous liquid hydrophilic polymer carrier of the present composition is about 5-
85wt%.Preferably, the quantity that liquid polymers exists is about 55-about 70wt%.
Adhesiving reinforcing agent
Adhesiving reinforcing agent is used for the compositions of the present invention to strengthen the adhesion property of anhydrous hydrophilic polymer and to include inorganic material
Material and organic natural and synthetic polymer.Inorganic material includes amorphous silica compounds, and it is used as thickening agent, including
With trade mark such as Cab-o-sil calcining silicon dioxide obtain manufactured by Cabot Corporation and by
The colloidal silicas compounds of LenapeChemical, bound Brook, NJ distribution；From J.M.Huber Chemicals
Division, Havre de Grace, the Zeodent165 of MD 21078；Also referred to as Sylodent 15, purchased from Davison
The Sylox 15 of Chemical Division, W.R.Grace Corporation, Baltimore, MD 21203.
The preferably silicon dioxide compound of amorphous calcined can use powder type from Degussa Company with commodity
Title " Aerosil " obtains.Various types of Aerosil can be dependent on the change in manufacturing process and obtain.Aerosil 200 is
The silicon dioxide of hydrophilic calcining, surface area is about 200 square metres every gram, and particle mean size is about 10-12 nanometer and densification table
See density about 50g/l and be preferred for the practice of the present invention.
The organic polymer of the adhesiving reinforcing agent used in putting into practice as the present invention includes hydrophilic polymer such as carbomer
Such as carboxymethylene polymers such as acrylate copolymer and acrylic copolymer.Carbomer is light containing pendant carboxylic group
Slightly acidic polyvinyl.The carbomer being preferred for present invention practice is to about with about 0.75%
1.5% polyallylsucrose crosslinking acrylic copolymer, it with trade name Carbopol 934,974 by
B.F.Goodrich sells.
Hydrophobic organic materials also serves as the adhesiving reinforcing agent in present invention practice, including hydrophobic material such as wax such as honeybee
Wax, mineral oil, plastigel (mineral oil and the blend of polyethylene), vaseline, white vaseline, versagel (liquid paraffin,
The blend of butylene/ene/styrene hydrogenated copolymer) acrylate and vinyl acetate polymer and copolymer, polyethylene
Wax, siloxane polymer such as polydimethylsiloxane, silicone elastomer, organic siliconresin, silicone rubber and polyvinyl pyrrole
Pyrrolidone/vinyl acetate co-polymer.
A small amount of anhydrous solvent such as ethanol and wetting agent such as glycerol can also be used for regulating the viscosity of fluid present invention compositions
And quantity is about 0.1-about 25wt% and preferably from about 0.3-about present in the on-aqueous liquid Lightening compositions of the present invention
20wt%.
Anhydrous brightening agent
Anhydrous brightening agent for present invention practice includes the anhydrous compound containing peroxide such as urea peroxide, percarbonic acid
Sodium, Dexol and PVP-H2O2 complex (hereinafter referred to as " PVP-H2O2 ").The linear complex with crosslinking of both PVP-H2O2
It is known in the art and is disclosed in US 3,376,110 and US 3,480,557 and for treating the compositions of acne vulgaris
(US 5,122,370).PVP-H2O2 complex is disclosed in US 5,122,370.PVP-H2O2 is stable in water-less environment.
By being exposed to aqueous environment, as in the oral cavity, brightening agent is dissociated into single material (PVP polymer and H2O2).PVP-H2O2
Complex is generally made up of about 80wt% polyvinyl pyrrolidone and 20wt%H2O2.
Anhydrous brightening agent concentration present in the liquid whitening composition of the present invention is about 1-about 50wt% and is preferably
About 10-about 25wt%.
Surfactant
The nonionic surfactant compatible with peroxide compound is used as solubilizing agent, dispersant, emulsifying agent and wetting agent also
If the spice being included in solubilising in liquid whitening composition is the most effective.Useful especially nonionic surfactant is mountain
Pears alcohol and the water-soluble polyoxyethylene monoesters of C10-C18 fatty acid, sell with Tween trade mark.Tween surfactant is Pyrusussuriensis
The mixture of the C10-C18 fatty acid ester of alcohol (with sorbitol anhydride), is mainly made up of monoesters, and with about 10-30, preferably from about 20 rub
That ethylene oxide condensation.Fatty acid (aliphatic series hydrogen carbonyl monocarboxylic acid) can be saturated or undersaturated, as lauric acid, Palmic acid,
Stearic acid, oleic acid.TWEEN-20 (such as Tween20) is particularly preferred and commonly referred to polyoxyethylene (20) anhydrosorbitol
Alcohol monolaurate.Nonionic surfactant constitutes the about 0-50wt% and preferably 0.5-40wt% of fluid composition.
Spice
The on-aqueous liquid Lightening compositions of the present invention also can comprise fumet.For the present invention practice fumet include quintessence oil with
And various flavouring aldehyde, ester, alcohol and analog material.The example of quintessence oil include Mentha viridis L, Herba Menthae, checkerberry, Cinnamomum porrectum (Roxb.) Kosterm., Flos Caryophylli, Salvia farinacea,
The oil of Eucalyptus, Origanum majorana L., Cortex Cinnamomi, Fructus Citri Limoniae, Citrus aurantium Linn., grapefruit and Fructus Citri junoris.The most usefully chemicals such as menthol, carvone
And fenchene.In these materials, most commonly use the oil of Mentha viridis L, Herba Menthae and checkerberry.By fumet with about 0.1-about
The concentration of 2wt% and preferably from about 0.1-about 0.5wt% introduces the whitening liquid composition of the present invention.
Sweetened material also serves as the fill-in of flavouring materials.Suitably sweetener is water miscible and includes saccharin sodium, ring
Own sulfamic acid sodium, xylitol, perillartine, D-trp, aspartame, dihydrochalcone etc., concentration is about 0.01-about
1wt%.Preferably saccharin sodium.
The on-aqueous liquid Lightening compositions of the present invention is to comprise the form system of the flowable viscous liquid suspension of brightening agent
Standby and be in statu quo applied on the tooth of user, as by smearing with the brushing of soft applicator.User leaves one after applying on tooth
Thickness liquid suspension liquid layer.Cause the H2O2 dental area to being applied from anhydrous lightening compounds slow of contacting with saliva
Release, it is provided that dental area brighten process for a long time.
Liquid suspension liquid layer containing peroxide does not comprise its unacceptable taste of imparting or the composition of quality, this composition
It is made to make user unhappy and be adhered strongly on tooth enamel.Suspension be enough viscosity and adhesion with at tooth
The power that upper reservation certain time, e.g., from about 5-about 30 minutes is generally applied by lip and tongue to cause whitening effect and opposing.To the greatest extent
The liquid whitening composition layer that pipe applies is in place, but user to avoid chewing.Lightening compositions can be as anticipated with pressing when needed
It is willing to such as be brushed teeth by standard oral hygiene procedures or remove by rinsing with alcohols collutory.Coatings scavenger while in place
Under the low and speed of relative constancy and use and be enough to effectively carry out stain and be included in from the concentration that tooth removes.
Peroxide activator
Peroxide decomposition activator such as sodium bicarbonate, sodium carbonate, manganese gluconate can introduce the liquid whitening of the present invention and coagulate
Glue composition.Due to anhydrous composition, so in the presence of working as in the non-aqueous liquid compositions of storage, oxide is increased by activator
White agent is the most inactive.When being applied to the liquid whitening composition of tooth with saliva contacts in oral cavity, activator
Effect is to discharge oxygen with peroxide reactions.Peroxide activator is dense present in the non-aqueous liquid compositions of the present invention
Degree is about 0-about 10wt% preferably from about 1-about 5wt%.
Other composition of the liquid whitening composition that can introduce the present invention includes being generally used for mouth care preparaton
Any material.These materials include: antibacterial, such as DP300, chlorhexidine, copper-, zinc-and tin salt such as zinc citrate, sulphuric acid
Zinc, zinc glycinate, sodium citrate zinc and ditin diphosphate, sanguinarine extract, metronidazole, quaternary ammonium compound such as Cetylpyridinium chloride
Yl pyridines；Biguanide, such as chlorhexidine gluconate, hexetidine, octenidine, alexidine；With halogenated bisphenol compound, such as 2,
2 '-di-2-ethylhexylphosphine oxide-(4-chloro-6-bromophenol)；Antiinflammatory, as ibuprofen, fluorine ratio cough up sweet smell, aspirin, indomethacin etc.；Preventing decayed tooth
Agent, as sodium-, calcium-, magnesium-and stannous fluoride, amine fluoride, single fluorophosphoric acid disodium and sodium trimetaphosphate；Dental plaque buffer agent, as
Urea, calcium lactate, calcium glycerophosphate and polyacrylic acid strontium；Vitamin such as vitamin C；Plant extract；Desensitizer, such as citric acid
Potassium, potassium chloride, Soluble tartar., potassium bicarbonate, potassium oxalate, potassium nitrate and strontium salt；The reagent of effective anti-dental tartar, as included
The alkali-metal pyrophosphate of mono-, di-, three and four and ammonium pyrophosphate and tripolyphosphate；Biomolecule, such as bacillin, antibody, enzyme
Such as papayotin, glucoamylase；Opacifier, pigment, coloring agent and have anticaries effectiveness fluoride ion supply salt such as
Sodium fluoride, potassium fluoride, stannic fluoride such as stannous fluoride.
Prepared by compositions
By adding in suitable container such as stainless cylinder of steel with blender and the composition of blend compositions prepares the present invention
On-aqueous liquid Lightening compositions.In the preparation of liquid whitening composition, order below is used to be advantageously added composition mixed
In clutch: hydrophilic polymer, anhydrous peroxide compound brightening agent, adhesiving reinforcing agent, peroxide activator and any
Required fumet or sweetener.Then blending constituent is to form uniform dispersion/solution.
The present invention is illustrated by below embodiment, but the most restricted.
Embodiment
The composition listed is used to prepare a kind of on-aqueous liquid combination medicament for planting tooth later stage toothcare.
Polyethylene Glycol 65%
Acrylic copolymer 1.5%
SODIUM PERCARBONATE 13.5%
Lauric acid 20%
By sealed plastic bottle intermediate package compositions and bottle is exposed to 120 °F measure Table I on-aqueous liquid tooth whitening composition
The bin stability of thing.Iodine quantitative titration method is used to measure after the temperature exposure 4 weeks to 120 °F from liquid whitening composition
The hydrogen peroxide percentage ratio reclaimed.Even if peroxide recovery result display on-aqueous liquid Lightening compositions is at the high temperature of 120 °F
Lower storage was also effective Lightening compositions after 4 weeks.
It is embodiments of the invention as mentioned above.The present invention is not limited to above-mentioned embodiment, and anyone should learn
The structure change made under the enlightenment of the present invention, every have same or like technical scheme with the present invention, each falls within this
Within the protection domain of invention.
Claims (4)
1. the on-aqueous liquid combination medicament being used for planting tooth later stage toothcare, it is characterised in that: can accept anhydrous in oral cavity
Scattered anhydrous peroxide compound in hydrophilic polymer and adhesiving reinforcing agent, said composition is when being applied topically to tooth table
Forming the adhesion coating comprising peroxide compound during face, wherein said peroxide compound discharges from layer to carry out tooth subsequently
Tooth brightens；Described anhydrous peroxide compound is SODIUM PERCARBONATE；Described anhydrous peroxide compound is PVP/H2O2；Anhydrous
Hydrophilic polymer is liquid polymers；Anhydrous hydrophilic liquid polymer is Polyethylene Glycol；Described adhesiving reinforcing agent is acetic acid
Vinyl ester copolymers.
A kind of on-aqueous liquid combination medicament for planting tooth later stage toothcare the most according to claim 1, its feature exists
In: the concentration that described PVP/H2O2 exists in the composition is 3wt%.
A kind of on-aqueous liquid combination medicament for planting tooth later stage toothcare the most according to claim 1, its feature exists
In: the quantity that described SODIUM PERCARBONATE exists in the composition is about 55wt%.
A kind of on-aqueous liquid combination medicament for planting tooth later stage toothcare the most according to claim 1, its feature exists
In: the quantity that described anhydrous liquid hydrophilic polymer exists in the composition is 90wt%.
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| CN201610636487.1A CN106236607A (en) | 2016-08-05 | 2016-08-05 | A kind of on-aqueous liquid combination medicament for planting tooth later stage toothcare |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2019108194A1 (en) * | 2017-11-30 | 2019-06-06 | Colgate-Palmolive Company | Oral care compositions |
| US11141364B2 (en) | 2017-11-30 | 2021-10-12 | Colgate-Palmolive Company | Oral care compositions |
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| CN1835728A (en) * | 2003-08-15 | 2006-09-20 | 高露洁-棕榄公司 | Non-aqueous liquid tooth whitening composition |
| CN102188335A (en) * | 2003-10-14 | 2011-09-21 | 高露洁-棕榄公司 | Tooth whitening composition |
| CN102988202A (en) * | 2012-10-13 | 2013-03-27 | 慈溪市锐玛电子有限公司 | Biological-care toothpaste composition |
| CN103998009A (en) * | 2011-12-20 | 2014-08-20 | 高露洁-棕榄公司 | Oral care whitening compositions |
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2016
- 2016-08-05 CN CN201610636487.1A patent/CN106236607A/en active Pending
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1835728A (en) * | 2003-08-15 | 2006-09-20 | 高露洁-棕榄公司 | Non-aqueous liquid tooth whitening composition |
| CN102188335A (en) * | 2003-10-14 | 2011-09-21 | 高露洁-棕榄公司 | Tooth whitening composition |
| CN103998009A (en) * | 2011-12-20 | 2014-08-20 | 高露洁-棕榄公司 | Oral care whitening compositions |
| CN102988202A (en) * | 2012-10-13 | 2013-03-27 | 慈溪市锐玛电子有限公司 | Biological-care toothpaste composition |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2019108194A1 (en) * | 2017-11-30 | 2019-06-06 | Colgate-Palmolive Company | Oral care compositions |
| CN111386101A (en) * | 2017-11-30 | 2020-07-07 | 高露洁-棕榄公司 | Oral care compositions |
| AU2017441056B2 (en) * | 2017-11-30 | 2021-04-08 | Colgate-Palmolive Company | Oral care compositions |
| US11141364B2 (en) | 2017-11-30 | 2021-10-12 | Colgate-Palmolive Company | Oral care compositions |
| CN111386101B (en) * | 2017-11-30 | 2023-10-13 | 高露洁-棕榄公司 | Oral care compositions |
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Application publication date: 20161221 |
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| RJ01 | Rejection of invention patent application after publication |