CN106163399A

CN106163399A - Measurement apparatus, measuring method, program and record medium

Info

Publication number: CN106163399A
Application number: CN201580016035.7A
Authority: CN
Inventors: 佐藤英雄
Original assignee: Sony Corp
Current assignee: Sony Corp
Priority date: 2014-03-31
Filing date: 2015-02-09
Publication date: 2016-11-23
Anticipated expiration: 2035-02-09
Also published as: WO2015151587A1; US20170135616A1; US10542920B2; CN106163399B; JPWO2015151587A1; JP6539877B2

Abstract

The problem to be solved in the present invention is: more simply measure the scattering coefficient arbitrarily measuring internal composition at place at organism.It is a kind of measurement apparatus that the present invention solves the technical scheme of this problem, comprising: light source, it is configured to being launched at least one the measurement light belonging to predetermined band by least some of measured zone formed of organism；Detector unit, multiple sensor it is arranged with regularly by predetermined deployment in this detector unit, this detector unit and described light source are set on the same side relative to described measured zone, and the reflection light that this detector unit described measurement light of a part of being configured to use the plurality of sensor to detect through described organism is reflected by described organism；And analytic unit, it is configured to the scattering properties using the testing result of the described reflection light detected by described detector unit to analyze the described internal composition being present in described organism.

Description

Measurement apparatus, measuring method, program and record medium

Technical field

The present invention relates to measurement apparatus, measuring method, program and record medium.

Background technology

Along with the concern to health recently increased, people are for need not go to medical institutions just can carry out about individual The simple demand measured of the information of person situation increased.Specifically, for individual human body fluid (such as, blood) composition The demand that the situation of concentration or individual's pulse is simply measured increased.

In order to meet this demand, it has for instance been proposed that for the various measurement dresses measuring the concentration of glucose in blood Put.The example of the measuring method of concentration of glucose includes: use the such as optical characteristics such as light absorption or Raman (Raman) spectrum Measure spectrum distribution or the method for light intensity；And utilize the scattering coefficient of bio-tissue can be because of the concentration of glucose in blood The method change of light scattering measured the fact that change and change.

Such as, following patent documentation 1 proposes a kind of technology, and it utilizes the scattering coefficient of bio-tissue can be because of in blood The change of concentration of glucose and the fact that change, and then measure by allowing near infrared light incide on bio-tissue Scattering coefficient estimates blood sugar level.

Quote list of documents

Patent documentation

Patent documentation 1: Japanese Patent Application Laid-Open JP2006-122579A

Summary of the invention

Solve the technical problem that

But, the use disclosed in patent documentation 1 is straight owing to employing through the technology of the direct light of bio-tissue Penetrate light thus be only applicable to thin position.

The present invention is designed in view of the most above-mentioned situation, and expects that offer can more simply be measured at biology The measurement apparatus of scattering coefficient of internal composition, measuring method, program and the record medium of arbitrarily measuring position of body.

Solve the technical scheme of technical problem

According to the present invention, it is provided that a kind of measurement apparatus, it includes: light source, it is configured to by organism at least The measured zone that a part is formed launches at least one the measurement light belonging to predetermined band；Detector unit, in this detector unit Being arranged with multiple sensor regularly by predetermined deployment, described detector unit and described light source are relative to described measured zone quilt It is arranged on the same side, and described detector unit is configured to use the plurality of sensor to detect through described organism The reflection light that the described measurement light of a part is reflected by described organism；And analytic unit, it is configured to use by described The testing result of the described reflection light that detector unit detects analyzes the scattering of the internal composition being present in described organism Characteristic.

According to the present invention, it is provided that a kind of measuring method, it includes: formed to by least some of of organism from light source Measured zone launch belong to predetermined band at least one measure light；By with described light source relative to described measured zone quilt It is arranged on the detector unit of the same side, utilizes the multiple sensings arranged regularly by predetermined deployment in described detector unit Device detects the reflection light that the described measurement light of the part through described organism is reflected by described organism；And utilize institute The testing result of the described reflection light detected analyzes the scattering properties of the internal composition being present in described organism.

According to the present invention, it is provided that a kind of program, the computer that it allows to communicate with a kind of measurement module realizes one Analytic function.Described measurement module includes: light source, and described light source is configured to by least some of survey formed of organism Amount field emission belongs at least one measurement light of predetermined band；And detector unit, by reservations in described detector unit Affixing one's name to and be arranged with multiple sensor regularly, described detector unit is arranged on same with described light source relative to described measured zone Side, and the described detector unit part that is configured to use the plurality of sensor to detect through described organism The reflection light that described measurement light is reflected by described organism.Described analytic function is: uses and is detected by described detector unit The testing result of described reflection light analyzes the scattering properties of the internal composition being present in described organism.

According to the present invention, it is provided that a kind of record medium for recording said procedure.

According to the present invention, belong to predetermined band at least to being launched by least some of measured zone formed of organism A kind of measurement light.By being arranged on the detector unit of the same side relative to described measured zone with described light source, utilize described The multiple sensors arranged regularly by predetermined deployment in detector unit detect the part through described organism The reflection light that reflected by described organism of described measurement light.The testing result using detected described reflection light is analyzed The scattering properties of the internal composition being present in described organism.

Beneficial effects of the present invention

According to the above-mentioned present invention, it is possible to more simply measure the internal composition of arbitrarily measuring position at organism Scattering coefficient.

It should be noted that the effect above is not necessarily determinate, and together with these effects or except these Outside effect, the present invention can present in this specification any effect wanting to introduce or can be intended from this specification Other effect.

Accompanying drawing explanation

Fig. 1 shows the explanatory diagram of exemplary human's skin texture model.

Fig. 2 A shows the explanatory diagram of the structure of common survey device.

Fig. 2 B shows the explanatory diagram of the structure of common survey device.

Fig. 3 is the explanatory diagram for explaining the Lambert-Beer's law of extension (extended Lambert-Beer law).

Fig. 4 shows the block diagram of the structure of measurement apparatus according to the first embodiment of the invention.

Fig. 5 is to schematically show the structure according to measuring unit included in the measurement apparatus of the present embodiment to show The explanatory diagram of example.

Fig. 6 is to schematically show the structure according to detector unit included in the measuring unit of the present embodiment to show The explanatory diagram of example.

Fig. 7 A is to schematically show the structure according to measuring unit included in the measurement apparatus of the present embodiment The explanatory diagram of example.

Fig. 7 B is to schematically show the structure according to measuring unit included in the measurement apparatus of the present embodiment The explanatory diagram of example.

Fig. 7 C is to schematically show the structure according to measuring unit included in the measurement apparatus of the present embodiment The explanatory diagram of example.

Fig. 8 is the explanatory diagram for explaining the measurement processing performed by the measuring unit according to the present embodiment.

Fig. 9 is the explanatory diagram for explaining the measurement processing performed by the measuring unit according to the present embodiment.

Figure 10 is for explaining in the explanatory diagram according to the reflection light detected in the measurement apparatus of the present embodiment.

Figure 11 is for explaining in the explanatory diagram according to the reflection light detected in the measurement apparatus of the present embodiment.

Figure 12 is to schematically show according to another of measuring unit included in the measurement apparatus of the present embodiment The explanatory diagram of individual structure example.

Figure 13 shows the flow chart of the flow example of the measuring method according to the present embodiment.

Figure 14 is the frame of the hardware construction schematically showing the measurement apparatus according to one embodiment of the invention Figure.

Detailed description of the invention

Hereinafter, with reference to the accompanying drawings the preferred embodiments of the invention are described in detail.In this specification and attached In figure, the element with function and the structure being substantially the same will use identical reference marker to mark, and will omit The explanation repeated.

To illustrate in the following order.

1. the investigation of inventor

1.1 human body skin structural models

The structure of 1.2 common survey devices

2. the first embodiment

2.1 measurement apparatus

2.2 measuring method

The hardware construction of 2.3 measurement apparatus

1. the investigation of inventor

Before the measurement apparatus according to embodiment of the present invention and measuring method are illustrated, first will be with reference to figure 1 to Fig. 3 illustrates content and the result that inventor investigates.Fig. 1 shows saying of exemplary human's skin texture model Bright figure.Fig. 3 is the explanatory diagram of the Lambert-Beer's law for explaining extension.Fig. 2 A to Fig. 2 B shows common survey device The explanatory diagram of structure.

1.1 human body skin structural models

First, will carry out, with reference to Fig. 1, the skin texture mould that brief description obtains by being modeled human body skin structure Type.

As it has been described above, have been developed over using non-invasive optical measurement to the such as glucose being present in human body, in vain Albumen, advanced glycation end products (AGE:Advanced Glycation Endproduct), cholesterol and oxidation/reduction are blood red The technology that the blood such as albumen and body fluid components measure.

How the skin texture to human body is modeled for analyzing measurement data is critically important.As it is shown in figure 1, example Property human body skin structural model is 3 layer models.

3 layer models shown in Fig. 1 are such that the subcutaneous tissue that will be located in below the horny layer of skin and are modeled as epidermis Layer, skin corium and subcutaneous fat these three layers.In this 3 layer model, although depend on personal considerations, but horny layer be equivalent to away from Human body surface inwardly about 0.01mm to 0.02mm, epidermal area is equivalent to away from human body surface about 0.04mm to 0.15mm, and Subcutaneous fat is equivalent to away from human body surface the most several millimeters to several centimetres.

In skin texture, epidermal area there are melanin, and in skin corium, there are capillary tube.In capillary Pipe there are various blood constituent such as such as oxygenated haemoglobin and reduced hemoglobin etc., and in subcutaneous fat It is primarily present adipose cell.Therefore, these are become by skin texture model to be considered for using non-invasive optical to measure It is critically important for point measuring.

Incidentally, the human body with aforementioned skin texture is light-scattering body, and it is known that the light of shorter wavelength It is easier to send out and is scattered.Such as, being directed to the light of 633nm wavelength, the scattering coefficient of human body skin is in epidermal area and skin corium For 27mm^-1, and be 12.6mm in subcutaneous fat^-1.On the other hand, when considering the skin texture model shown in Fig. 1, light Mainly scatter in skin corium and subcutaneous fat.Light seldom scatters in epidermal area.

The structure of 1.2 common survey devices

Next, with reference to Fig. 2 A to Fig. 3, brief description uses non-invasive optical to measure being present in human body such as Blood and the body fluid components such as glucose, albumin, advanced glycation end products (AGE), cholesterol and oxidation/reduction hemoglobin The ordinary constitution of the measurement apparatus that (internal composition) measures.

In this common survey device, had by connection and measure the measuring unit of probe and bio information is measured. As shown in Figure 2 A and 2 B, this measurement probe is configured to include light source and photoelectric detector, and this measurement probe measurement by The light scattering that organism causes is over time.About by measure probe measurement to the measurement result of light scattering be output to Analytic unit, and the concentration etc. calculating the internal composition paid close attention to based on the measurement result obtained.

In this measurement apparatus, it is necessary to use the light of at least one wavelength as the light (measurement light) launched to organism. Here, generally it is used as to measure light, this is because this light to the light of the wavelength of this wave band of near infrared light from HONGGUANG by having to belong to Can easily arrive inside organism.

In the measurement probe of this measurement apparatus, as shown in Figure 2 A and 2 B, light is measured from light source to the skin of organism Surface emitting, thus there is straightline propagation, reflect or scatter in portion in vivo, therefore, from the outgoing luminous energy of organism injection Enough detected by photoelectric detector.Here, the transmission-type measurement apparatus shown in Fig. 2 A is mounted so that light source and photoelectric detector Facing with each other, and a part (such as, finger) for organism is between both.This photoelectric detector detects at organism In be scattered in the case of the emergent light that is transmitted out.Reflective measurement apparatus shown in Fig. 2 B be mounted so that light source and Photoelectric detector is positioned at the same side of a part for organism.This photoelectric detector detection by organism occur reflection or Scatter thus with the generally U-shaped emergent light carrying out and propagating.Now, measure light partly by the tremulous pulse in organism, vein or its Its bodily tissue absorbs, and measured as emergent light.

This measurement apparatus uses the Lambert-Beer's law of extension, in order to by measured real data with because being paid close attention to Internal composition (or oxygenated haemoglobin or reduced hemoglobin etc.) and the absorbing amount that causes are associated.About organism or For person is used for making the object (light-scattering body) of light scattering, common survey device it is considered that the propagation in light portion in vivo, So the common Lambert-Beer's law not considering scattering/spreading effect can not be used.Therefore, common survey device use with The Lambert-Beer's law of extension represented in lower formula 11, is thus analyzed the measurement data obtained.Below will ginseng According to Fig. 3, the Lambert-Beer's law of extension is briefly described.

Mathematical expression 1

Here, in superincumbent formula 11, it is defined as follows:

λ: the wavelength of the light paid close attention to,

The absorbance (degree of photoabsorption) of A (λ): wavelength X,

I₀(λ): the intensity of the light of the wavelength X being incident in scattering object,

I (λ): through the detection intensity of light of the wavelength X of scattering object,

G (λ): the attenuation caused because of the scattering of light of wavelength X,

ε_i(λ): the light of the wavelength X absorption coefficient of light in material i, this absorption coefficient of light is the value that material is intrinsic,

C_i: the concentration of material i, and

I_i: the average optical paths length when the light of wavelength X is propagated in material i.

It is assumed here that the Lambert-Beer's law of extension is applied the scattering object to the Rotating fields having as shown in Figure 3.? Hereinafter, the quantity for specifying the footnote of a certain layer to be described as the material included in i, and layer i is represented by footnote j. Can be by equation 1 below 2 and formula for having the Lambert-Beer's law of the extension of the scattering object of Rotating fields as shown in Figure 3 13 express.

Mathematical expression 2

Here, in formula 12 and formula 13, it is defined as follows:

λ: the wavelength of the light paid close attention to,

A (λ): the absorbance of wavelength X,

ε_i(λ): the light of the wavelength X absorption coefficient of light in layer i,

C_i: the concentration of the material included in layer i,

I_i: the average optical paths length when the light of wavelength X is propagated in layer i,

ε_ij(λ): the absorption coefficient of light in the light of wavelength X material j included in layer i, and

C_ij: the concentration of the material j included in layer i.

Here, it is possible to by measuring the absorption spectrum of the internal composition paid close attention in advance or from generally known data base Obtain data, specify the absorption coefficient of light of the internal composition paid close attention to.Therefore, by using this data, that is paid close attention to is internal The absorption coefficient of light of composition can be processed as known quantity.The measurement light of each wavelength can be measured by using measurement apparatus Detection intensity and measured detection intensity and this measurement light intensity before entering organism is compared, calculate Absorbance in the leftmost side of formula 12.

In pulse oximeter (pulse oximeter), for the hemoglobin in the blood paid close attention to, because of exist with The combination of oxygen and absorbance can be caused to change, and absorbance depends on wavelength to be observed and different.Cause This, measure the absorbance of multiple wavelength, thus obtains the reduced hemoglobin (Hb) and oxidation blood not being combined with oxygen Ratio between Lactoferrin (HbO2).

Oxygenated haemoglobin ratio in the total hemoglobin that blood is comprised is referred to as blood oxygen saturation.Arterial blood oxygen Saturation SaO2 (arterial oxygen saturation) is useful especially for bio information, and can be following Formula 14 calculates this oxygen saturation SaO2.Previously described SpO2 is the SaO2 via skin measurement.

Mathematical expression 3

In formula 14, it is defined as follows:

SaO2: arterial oxygen saturation,

C_HbO2: the concentration of oxygenated haemoglobin, and

C_Hb: the concentration of reduced hemoglobin.

As it has been described above, during measurement light reflects in health/scatters, bodily tissue or blood constituent can be inhaled Receive the emergent light that the photoelectric detector measuring probe in measured device detects.Thus, the intensity of emergent light is analyzed To calculate SpO2, but owing to SpO2 is arterial oxygen saturation, thus need from emergent light get rid of because of except arterial blood it Outer any factor and impact that the light that causes absorbs.

The key element causing incident illumination generation light to absorb can probably be divided into three kinds, such as arterial blood, venous blood and other Bodily tissue.Now, emergent light occurs the light as represented by equation 1 below 5 to absorb.

Mathematical expression 4

In formula 15, it is defined as follows:

λ: wavelength,

ε: the absorption coefficient of light,

C: concentration, and

D: optical path length.

In formula 15, the Section 1 in the rightmost side represents that the light caused because of composition in addition to blood absorbs, Section 2 in You Ce represents that the light caused by venous blood absorbs, and the Section 3 in the rightmost side represents and caused by arterial blood Light absorbs, and the Section 4 in the rightmost side represents that the light caused because there is scattering in organism absorbs.

This common survey device utilizes the fact that only observe pulsation in tremulous pulse among these three key element, and permissible The light of arterial blood absorbs the light absorption with other key element separate.That is, formula 15 is by time diffusion, thus eliminates because not having The impact that the light having the vein of pulsation (or not changing over time) and other bodily tissue and cause absorbs.This derivation operation is suitable In utilizing frequency filter (frequency filter) to eliminate flip-flop in the signal processing, and this derivation operation is not Other process and impulse waveform extraction process just.

In formula 14, it is reduced hemoglobin concentration (C for calculating two unknown numbers of SaO2_Hb) and aoxidize blood red egg White concentration (C_HbO2), therefore, in order to specify the two unknown number, need to obtain two measurement results simultaneously.Therefore, measurement apparatus At least two wavelength is used to measure.

Suppose following situation below: use two kinds of incident illuminations of wavelength X 1 and λ 2 to measure, and obtain the strong of emergent light Spend Δ OD over time^λ1With Δ OD^λ2.In this case, it is possible in below equation 16, express profit based on formula 15 By the intensity of the emergent light measured by the two wavelength over time.Therefore, by using reduced hemoglobin and oxidation The absorption coefficient of light of hemoglobin and measurement result, it is possible to as in equation 1 below 7 to unknown reduced hemoglobin concentration (C_Hb) and oxygenated haemoglobin concentration (C_HbO2) calculate.

Mathematical expression 5

Therefore, when being substituted in formula 14 by formula 17, equation 1 below 8 can be obtained.In equation 1 below 8, parameter α, β and Φ are as shown in equation 1 below 9a to 19c.

Mathematical expression 6

It is as high-visible in the rightmost side from formula 18, it can be seen that: the value of SaO2 is as proportional to parameter Φ Function and be presented.As shown in formula 19c, parameter Φ is the impulse waveform measured by wavelength X 1 and wavelength X 2 Ratio between amplitude.As shown in formula 19a and formula 19b, can count by the absorption coefficient of light based on hemoglobin in theory Calculate parameter alpha and β, but in many cases, parameter alpha and β need based on the conversion table obtained by previous experiment quilt Calibration.This is because: by doing that, it is possible to the condition making Lambert-Beer's law set up and the physical condition in organism Between difference be modified.

According to such method, this measurement apparatus can also utilize measurement result that two kinds of wavelength obtain to count by use Calculate arterial oxygen saturation SpO2 and realize the function of pulse oximeter.

By utilizing scattering coefficient at each layer (epidermal area, skin corium and the subcutaneous fat of the skin texture model shown in Fig. 1 Fat) in different the fact or internal composition etc. to be measured absorb the light of specific wavelength specifically and (that is, have certain wave The fact that long absorption characteristic), measurement apparatus can be for the various types of measurement light used by measurement, based on representing scattering system The information (such as, calibration curve) of the dependency relation between the component content of the internal composition counted and paid close attention to, calculates internal The component content of composition.

But, the measurement apparatus of transmission-type model as shown in Figure 2 A is only capable of applies the thin section position to organism, and this is Because it is to use the transmission light through organism to perform to process.Therefore, inventor contemplates use such as such as Fig. 2 B institute The measurement apparatus of the reflective model shown can measure any measurement position of organism making this measurement apparatus.Although such as This, set up the measurement apparatus of the reflective model of use the most well thus utilize the reflection light from organism reflection and based on dissipating Penetrate coefficient to calculate the technology of the component content of internal composition.For by use reflective measurement apparatus and can high accuracy Ground, more simply measure the technology of the scattering properties (especially, scattering coefficient) of internal composition, in addition it is also necessary to further adjusted Grind.

Then, inventor thoroughly have studied can more simply measure in any measurement position of organism internal The measurement apparatus of the scattering coefficient of composition, and therefore, complete the measurement according to embodiment of the present invention that will be explained below Device.

2. the first embodiment

Hereinafter, with reference to Fig. 4 to Figure 12, measurement apparatus according to the first embodiment of the invention will be carried out in detail Explanation.

Fig. 4 shows the block diagram of the structure of the measurement apparatus according to the present embodiment.This is first according to the present invention The block diagram of the structure of the measurement apparatus of embodiment.Fig. 5 is to schematically show according in the measurement apparatus of the present embodiment The explanatory diagram of the structure example of included measuring unit.Fig. 6 is to schematically show the measurement list according to the present embodiment The explanatory diagram of the structure example of detector unit included in unit.Fig. 7 A to Fig. 7 C is to schematically show according to this reality respectively Execute the explanatory diagram of the structure example of measuring unit included in the measurement apparatus of scheme.Fig. 8 and Fig. 9 is for explaining by basis The explanatory diagram of the measurement processing that the measuring unit of the present embodiment performs.Figure 10 and Figure 11 is for explaining by according to this embodiment party The explanatory diagram of the reflection light that the measurement apparatus of case detects.Figure 12 is to schematically show the measurement dress according to the present embodiment The explanatory diagram of another structure example of measuring unit included in putting.

2.1 measurement apparatus

The unitary construction of measurement apparatus

First, with reference to Fig. 4, the unitary construction of the measurement apparatus 10 according to the present embodiment will be described in detail.

Measurement apparatus 10 according to the present embodiment is following device: it uses the light (measurement light) of predetermined wavelength to conduct The organism B measuring object measures, and based on the measurement result the obtained internal composition to being present in organism B Scattering properties be analyzed.Such as, based on the measurement result obtained, measurement apparatus 10 calculates such as glucose, albumin (albumin), the blood such as advanced glycation end products (AGE), cholesterol, oxidation/reduction hemoglobin and water and body fluid components are (internal Composition) component content.

As shown in Figure 4, measurement apparatus 10 specifically includes that for measuring the measuring unit 101 of organism B, control unit 103, analytic unit 105 and memory element 107.

Measuring unit 101

First, with reference to Fig. 5 to Figure 11, the structure of the measuring unit 101 according to the present embodiment will be specifically described. As it is shown in figure 5, be made up of light source 111 and detector unit 113 according to the measuring unit 101 of the present embodiment.

Light source

Light source 111 is for analyzing the scattering properties of the internal composition in organism, and belongs to pre-standing wave to organism B transmitting The measurement light of section.Light source 111 is disposed in predetermined frame (not shown), so that measuring the surface of emission of light in the face of organism B. Light source 111 is launched to have and is suitable for use with the measurement apparatus 10 of the present embodiment and measures the wavelength of the internal composition paid close attention to Light, and a type of light or polytype light can be launched.

As already explained, the scattering coefficient of the skin corium in human body skin structure is subcutaneous more than be positioned in deeper portion The scattering coefficient of fat.Therefore, can major part be scattered skin corium from the measurement light that skin surface is incident to inner side.In It is that the light of measuring being scattered in skin corium diffuses to have the region measuring light bigger on a large scale than incidence, thus serves as two Secondary light source.Measurement apparatus 10 according to the present embodiment is efficiently used this secondary souce, thus causes in broader scope There is the light scattering of the impact bigger than the impact caused because the light of skin texture and internal composition absorbs, thus increase The sensitivity of the reflection light detected by the detector unit 113 that will illustrate after a while.As a result, though reflective as shown in Figure 5 Model device structure in, it is also possible to accurately detection through organism a part measure light from organism reflect anti- Penetrate light.

The wavelength measuring light launched by light source 111 can be subordinated to the wavelength of visible light wave range to belonging near infrared band Wavelength in select, and can be set appropriately according to the internal composition paid close attention to.Such as, tool is launched when light source 111 When having the light of 940nm or 950nm wavelength, it is possible to obtain about the information of the fat in subcutaneous tissue.Launch when light source 111 and have During the light of 568nm, 580nm, 660nm or 890nm wavelength, it is possible to obtain about melanin or such as oxygenated haemoglobin and reduction The information of the blood constituents such as hemoglobin.When light source 111 launches the light with 1400nm to 2200nm wavelength, it is possible to obtain have Close the information of glucose.For example, it is possible to launch from light source 111 in the way of the time-division (time-divison), there is multiple wavelength Light, or the light with multiple wavelength and the optics by suitably layout afterwards with wave band restriction can also be launched simultaneously Wave filter and there is described in the detector unit 113 that will illustrate below makes the light of multiple wavelength and separate.

Above-mentioned various wavelength are exemplary only, and the light source from the measurement apparatus 10 according to the present embodiment 111 light launched are not limited to above example.

Such as, light source 111 can use light emitting diode (LED:light emitting diode) or miniature laser Deng, and one or more this light-emitting device can be provided with for use as light source 111.

Measuring the aspects such as the launch time of light, to be launched intensity measuring light, light source 111 is by illustrating after a while The control of control unit 103.

Detector unit

The detector unit 113 being arranged in the measurement apparatus 10 according to the present embodiment has by predetermined arrangement mode The multiple sensors being arranged in regularly in detector unit 113, and detector unit 113 is intended to use these sensors to from light The reflection light that the measurement light of that source 111 is launched and through organism B a part is reflected by organism B detects.In other words, Detector unit 113 according to the present embodiment is made up of so-called multi-tap (multi-tap) sensor.Fig. 6 shows employing The sensor of microlens array (MLA:micro lens array) is for use as exemplary detection unit 113.

As shown in Figure 6, mainly wrap according to detector unit 113 included in the measurement apparatus 10 of the present embodiment Include: the first occulter 121, microlens array the 123, second occulter 127, hole (diaphragm) 129 and sensor 131.In detection In unit 113, can be provided with transparency carrier at the previous stage of the first occulter 121, this transparency carrier can make from light source The light transmission of wave band belonging to the measurement light that 111 launch.By arranging this transparency carrier, can be relative to a part of organism B And protect detector unit 113.Such component is scheduled framework F and integrally supports.

First occulter 121 serves as the directivity panel of the directivity for controlling the reflection light from organism B, and It is arranged on the boundary between the lenticule 125 adjacent one another are in the microlens array 123 that will illustrate after a while.First hides Body of light 121 is configured such that the directivity of the reflection light being incident in each lenticule 125 can controlled be made, and this makes to measure more Add accurately.It is directed to microlens array 123 by the reflection light of the first occulter 121.

As shown in the top part of figure 6, microlens array 123 is made up of the multiple lenticulees 125 as optical receiver lens, and Each lenticule 125 is arranged in predetermined substrate with mesh shape with y direction in the x-direction.Each lenticule 125 will be incident to lenticule Reflection light in 125 guides to the sensor 131 that will illustrate after a while.Microlens array 123 has less image field curvature, And do not distort along depth direction.Thereby, it is possible to use this microlens array 123 to obtain good measurement data.I.e. Organism B is made to be positioned at feature distance (close-up distance), it is also possible to each micro-of microlens array 123 will to be constituted The depth of field (depth of field) of mirror 125 is set to contain and utilizes the skin paid close attention to according to the measurement apparatus 10 of the present embodiment Skin structure (such as, until focusing in the range of several millimeters of body surface to the degree of depth of tens of milliseconds).

The quantity of the lenticule 125 arranged in the microlens array 123 according to the present embodiment is not limited to Fig. 6's Example shown in top.The quantity of the lenticule 125 arranged in the microlens array 123 according to the present embodiment can rely on Freely set in size or the size of sensor 131 of organism to be captured.

The reflection light being incident in microlens array 123 is focused in lenticule 125, with in the biography that will illustrate after a while Imaging on sensor 131.

Here, in the surface of sensor 131 side of microlens array 123, the second occulter 127 and hole (diaphragm) 129 are arranged on the boundary between lenticule 125 adjacent one another are.Second occulter 127 and hole 129 make through micro- Lens array 123 reflection light directivity can controlled make, and make the light being incident in each lenticule 125 can be incident to Light in neighbouring lenticule 125 separates.Thus, can select to be focused to sensing according to the measurement apparatus 10 of the present embodiment Reflection light in device 131.

Measurement apparatus 10 according to the present embodiment is provided with various occulter as above or hole, so that incident The angle of incidence of the light to each lenticule 125 is restricted, it is possible to prevent the lenticule 125 that causes because health scattering it Between crosstalk.Prevent the crosstalk between lenticule 125, thus obtain from the lenticule 125 being arranged on microlens array 123 Among the signal that obtains of the sensor pixel of some lenticule 125 correspondence (or corresponding with the local location in measured zone Signal), thus the temporal resolution of the data that just can improve the sensor 131 by being explained below and measure and space are divided Resolution.

Sensor 131 detects the intensity of the reflection light of the position in the x/y plane shown in the top of Fig. 6.Sensor The intensity-conversion of the reflection light received by photoelectric detector (PD) etc. is become to be output to the analysis list that will illustrate after a while by 131 The signal of telecommunication of unit 105.Sensor 131 can use such as photodiode, charge-coupled image sensor (CCD:Charge Coupled Device) imageing sensor, complementary metal oxide semiconductors (CMOS) (CMOS:Complementary Metal Oxide Semiconductor) imageing sensor, organic EL is used as the sensor of light receiving element or thin film transistor (TFT) (TFT: Thin Film Transistor) 2D (two-dimentional) face sensor such as imageing sensor.

The arranged beneath of one lenticule 125 has one or more pixel, and when setting accordingly with a lenticule 125 When being equipped with multiple pixel, control unit 103 or the software that will illustrate after a while can be controlled, so that not havinging because of micro- Distance between mirror 125 and subject and the inactive pixels that causes.

At aspects such as sweep times, the control unit 103 that sensor 131 will be illustrated after a while controls, and such as, passes The detection intensity of any position on the top at Fig. 6 can be exported to analytic unit 105 by sensor 131.

The concrete example of measuring unit structure

Next, with reference to Fig. 7 A to Fig. 7 C, the concrete example of the structure of the measuring unit 101 according to the present embodiment is entered Row brief description.Concrete example shown in Fig. 7 A to Fig. 7 C is only showing of the structure of the measuring unit 101 according to the present embodiment Example, and be not limited to shown in Fig. 7 A to Fig. 7 C according to the structure of the measuring unit 101 in the measurement apparatus 10 of the present invention Example.

In the example shown in Fig. 7 A and 7B, light source 111 and detector unit 113 in measuring unit 101 integrate, And light source 111 is disposed in the substantially central portion of the detector unit 113 using microlens array as shown in Figure 6.Here, As Fig. 7 A is schematically shown, light source 111 can be the small light sources such as such as LED, or as shown in Figure 7 B, light source 111 can be to wear Thoroughly use the LASER Light Source of the central part of the detector unit 113 of microlens array.

In the substantially central portion of detector unit 113, a light source 111 or multiple light source 111 can be mounted with.

In order to perform will to illustrate after a while to skin texture and the correcting process of internal composition, such as, as seen in figure 7 c, Measuring unit 101 may further include secondary light source 115, and this secondary light source launches the measurement being different from from light source 111 transmitting Second light of light.Although Fig. 7 C shows the secondary light source 115 being arranged around detector unit 113, but secondary light source The position of 115 is not limited to the example shown in Fig. 7 C, and secondary light source 115 can be intensively arranged in detection list In a part for unit 113.Identical with light source 111, can there be a secondary light source 115 or multiple secondary light source 115.

Below with reference to Fig. 5 to Fig. 7 C, the structure of the measuring unit 101 according to the present embodiment has been carried out specifically Bright.

When measuring operation in the place that there are exterior light in above-mentioned measuring unit, the impact of exterior light may Can be superimposed in testing result.Therefore, light is measured having an impulse form of the light intensity of increase launch from light source 111 Driven and measure light Tong Bu with the driving pulse of light source 111 time, utilize the testing result of sensor 131 to be obtained in that ratio The higher gain of exterior light as continuous light.

By arranging that there is the optically filtering that different-waveband limits for each pixel in sensor 131 or all pixels Device, for example, it is also possible to select the testing result of special wavelength such as such as 660nm, 800nm, 890nm or 940nm etc..

By driving light source 111 in the form of a pulse, it is possible to think: examined within the time period in addition to x time The light measured can be affected by exterior light.Therefore, by sensing within the time period in addition to x time detected Light, when detecting that sizable exterior light affects, the analytic unit 105 being explained below can be determined that measurement result is nothing Effect.

It addition, when organism is mobile in measuring during operation, blood flow can be produced impact, and this impact may It is superimposed on measured value.Therefore, the highest by the absorption of the hemoglobin in blood being detected such as 660nm or 890nm etc. Output valve become the situation of the amplitude much larger than pulse wave (pulsewave), the analytic unit 105 being explained below can be sentenced This measurement fixed failure.

The data measured by measuring unit

Below with reference to Fig. 8 to Figure 11, the data measured by the measuring unit 101 according to the present embodiment (are measured number According to) be described in detail.

Owing to human body is the medium that light can occur sizable scattering wherein, so such as it is shown in figure 5, from light source 111 launch and the measurement light that is incident on organism B scatter in organism B while with generally U-shaped propagation, and because of This, this measurement light can be installed in the detector unit 113 of specific location and detect.Now, as shown schematically in figure 8, from light Source 111 detector unit 113 farther out can detect the reflection light being scattered and being back to human body surface in deep position.That is, In fig. 8, along the x-axis direction can from light source 111 sensor (such as, the sensor at the right-hand member or left end of Fig. 8) farther out The measurement light penetrated deeply detected.May be considered about L/2 additionally, fathom, wherein, L represents light source 111 and is paid close attention to Sensor between spacing distance.The energy of the specific wavelength of reflection light because of present in light path various internal compositions and inhaled Receive, and the intensity reflecting light depends on the distance length (light path) of light propagation and decays.

Such as, in the schematic diagram of Fig. 9, by near light source 111 side on microlens array assemble and to pass through The reflection light that sensor carries out detecting has corresponded to by the various internal ingredient draws in skin layer energy and strength retrogression has occurred Reflection light, and straight corresponding to propagate at organism cathetus by the reflection light detected near the sensor of light source 111 Line style reflection light.Assembled by the microlens array on the side farthest from light source 111 and sensor to be passed through carries out detecting Reflection light has corresponded to by the various internal ingredient draws in skin layer, fat deposit and Musclar layer energy and has occurred strength retrogression's Reflection light, and corresponding to the scatter-type reflection light propagated in organism while being scattered.By middle lenticule battle array The reflection light that sensor that row are assembled and to be passed through carries out detecting is corresponding to by the various internal composition in skin layer and fat deposit Absorb energy and the reflection light of strength retrogression occurs, and corresponding to the scattering propagated in organism while being scattered Type reflection light.

Therefore, it is possible to think, the sensor corresponding to each position in microlens array the reflection detected just is wrapped Include the measurement data of the skin texture information being present in the detected light path reflecting light.

In the measurement apparatus 10 according to the present embodiment, characteristic based on this light, it is possible to use from shown in Fig. 4 Be positioned at the output (measurement data) of sensor at different x coordinate and to the light scattering at each sensing station and the characteristic of decay It is modeled.

In the measurement apparatus 10 according to the present embodiment, based on this light characteristic, it is possible to use from Fig. 8 and Fig. 9 institute The output (measurement data) of that shows the be positioned at sensor at different x coordinate and to the light scattering at each sensing station and decay Characteristic is modeled.

As it has been described above, have in the reflective measurement apparatus in generally U-shaped path measuring light, optical depth to be investigated becomes Change the biggest.Accordingly, it is capable to the good signal of no acquisition depends on measuring in the generally U-shaped path of light whether include internal composition and body The imaginary degree of depth of interior composition.

In the measurement apparatus 10 according to the present embodiment, can extract independently from the sensor using microlens array The signal obtained.Therefore, it is analyzed the output waveform from microlens array making it possible to select exactly and want to claim Distance between light source and sensor that the signal of the degree of depth gone out is corresponding.

As the measurement apparatus 10 according to the present embodiment reflective devices can near measurement object distance contracting It is as short as several millimeters.Additionally, can use in MLA optical system detection more tiny area according to the measurement apparatus 10 of the present embodiment Change.Depending on the position being used as the organism of measured zone, some regions may be capable to obtain well measures number According to position and on measure influential position (such as, the such as blood vessel such as tremulous pulse and vein, nevus and birthmark).According to this enforcement In the measurement apparatus 10 of scheme, it is possible to obtain the signal obtained from multiple lenticulees independently for process, so, after a while will The analytic unit 105 that can illustrate and control unit 103 can coordination with one another to be modified processing (such as, from processing object Eliminating may be on measuring influential position).This makes the measurement apparatus 10 according to the present embodiment be obtained in that good survey Amount data.

By this way, such as, as shown in Figure 10, it is obtained in that to biology according to the measuring unit 101 of the present embodiment The measurement scattering of light pattern (two-dimensional map image) that body B launches.Additionally, as it has been described above, the measurement light propagated in organism The skin texture that is comprised in organism of energy and internal ingredient draws, thus along with it propagates that light path is the longest and its intensity Become the lowest.

Here, the intensity that linear type reflects light is interpreted as and the intensity of the reflection light from light source location directly below (intensity of the secondary souce such as, produced by measuring scattering of light) is proportional.Therefore, by linear type is reflected light Intensity compares with the intensity at the reflection light (scatter-type reflection light) being positioned to imaging in the pixel that light source 111 is farther Relatively, the scattering coefficient being calculated the internal composition corresponding with the wavelength of measurement light used is enabled to.

Additionally, such as, as schematically shown in Figure 11, the space latitude of emulsion (spatial spread) of scattering pattern depends on institute The scattering coefficient of the internal composition paid close attention to.Specifically, along with the increase of scattering coefficient, the space latitude of emulsion of scattering pattern increases, and The intensity of linear type reflection light reduces.Along with the reduction of scattering coefficient, the space latitude of emulsion of scattering pattern reduces, and linear type reflection The intensity of light increases.Therefore, it is possible to by the space latitude of emulsion (such as, the skirt section of distribution using scattering pattern as shown in figure 11 Width (tail width) and half width) and the peak strength of reflection light (specifically, directly reflecting light) that detected calculate Scattering coefficient.Eigenvalue by scattering pattern such as the space latitude of emulsion of such as scattering pattern and peak strengths, it is also possible to by advance The information (such as, calibration curve) first obtaining the dependency relation represented between these characteristic values and the component content of internal composition is come Calculate the component content of internal composition.

Control unit 103

Return Fig. 4, the control unit 103 in the measurement apparatus 10 being arranged on according to the present embodiment will be illustrated.

Such as, control unit 103 is by central processing unit (CPU:Central Processing Unit), read-only storage Device (ROM:Read Only Memory) or random access memory (RAM:Random Access Memory) etc. realize.Control Unit 103 processed is controlled driving the light source 111 and 115 being arranged in measuring unit 101 and sensor 131 etc., thus The management whole measurement processing to organism B in measuring unit 101.More specifically, based on predetermined synchronizing signal etc., control Unit 103 processed controls the sweep time of such as sensor 131 or for obtaining the sensors such as the selection of the sensor 131 of information Drive.It addition, control unit 103 controls the driving in terms of the launch time measuring light or intensity of light source 111 and 115.

When control unit 103 performs above-mentioned driving control, the light source 111 and 115 in measuring unit 101 can be suitably Moment launches the measurement light of predetermined wavelength, and the analytic unit 105 being explained below can obtain on sensor 131 The measurement data of any position.

In the case of the driving of measuring unit 101 is controlled by control unit 103, arrived by measuring unit 101 measurement Measurement data is output to the analytic unit 105 that will illustrate after a while, carries out above-mentioned measurement data at this analytic unit 105 Analyze.

Here, when control measuring unit 101 time, control unit 103 can reference record in depositing of will illustrating after a while Various programs, parameter and database in storage unit 107.

Analytic unit 105

Such as, it is by CPU, ROM and RAM according to analytic unit 105 included in the measurement apparatus 10 of the present embodiment Deng realization.Analytic unit 105 use by measuring unit 101 detect reflection light testing result and in organism The scattering properties of internal composition is analyzed.

Specifically, according to the light path away from light source 111, (that is, in this position of sensor 131, sensor 131 detects Reflection light), detector unit 113 the reflection light detected is divided into when propagating at organism cathetus by analytic unit 105 The linear type reflection light reflected and the scatter-type reflection light reflected when being scattered in organism.Then, analytic unit 105 Based on the linear type reflection detection intensity of light, the detection intensity of scatter-type reflection light and the light path away from light source to internal composition Scattering coefficient calculate.That is, the reflection light detected by detector unit 113 being schematically shown according to such as Figure 10 and Figure 11 Intensity distributions pattern, the scattering coefficient of internal composition can be calculated by analytic unit 105.

Here, the reflection light how far being detected away from light source 111 is divided into the position of the directly sensor 131 of reflection light Put and be not restricted by, and can suitably set this position according to investigation before.

Additionally, rely on the feature of the scattering pattern such as the space latitude of emulsion and the peak strength of scattering pattern the most as shown in figure 11 Value, analytic unit 105 can be based on the information of the dependency relation represented between these characteristic values and the component content of internal composition And the component content of internal composition is calculated.

Here, it is so-called multi-tap sensor according to the detector unit 113 of the present embodiment, as shown in Fig. 6 etc., at this In multi-tap sensor, it is arranged with multiple sensor regularly by predetermined deployment.One pixel or multiple pixel are corresponding to one Individual lenticule.Owing to the image in lenticule is reversion up and down and left and right reversion, repaiied so analytic unit 105 can obtain The just two-dimensional map of position relationship, this two-dimensional map represents by by the intensity of the light about being exported by detector unit 113 Two-dimensional map (in other words, about detecting the image of the intensity of light) carries out reversion and processes the continuous print then carrying out being synthesized into Light quantity changes.

When the corresponding lenticule of multiple pixels, analytic unit 105 is by would correspond to lenticular multiple pictures The data of element synthesize, it is possible to increase the precision of data.Analytic unit 105 can perform following process: only obtains with micro- Lens are the representative value of unit, and utilize curve approximation to supply each lenticular value.

Analytic unit 105 can also obtain the attenuation curve of the brightness of lenticule self in advance, and uses this attenuation curve Revise the brightness step of lenticule self.

When using detector unit 113 grade shown in Fig. 6 etc., on each lenticular sensor surface, the figure of imaging The size of picture is to change according to the subcutaneous depth obtained at information.It is therefoie, for example, in skin corium is measured in expectation During body fluid components, analytic unit 105 is by determining the cut coverage of image and carrying out resynthesis so that obtaining relevant away from people The image of the information of the position of surface about 1mm depth can be continuous print, it becomes possible to obtain position continuous paid close attention to Image.

Here, based on the actual measurement data obtained from the sensor in each x coordinate position shown in Fig. 6 etc., for Each wavelength carries out such as multivariate analysis and processes by using the Lambert-Beer's law of previous extension, according to the present embodiment Analytic unit 105 in the position of each sensor, skin texture can be modeled.By being plotted in the position of each sensor Putting the absorbance of the internal composition at place, analytic unit 105 can also obtain the attenuation curve of light intensity.Can be for measuring light Each wavelength and generate attenuation curve, and characteristic wavelength can be selected using as survey when the internal ingredient draws paid close attention to The wavelength of amount light.Therefore, it is to represent declining of the trap of composition in particular volume about having the attenuation curve of the light of specific wavelength Subtract curve.

Such as, by the light of wavelength 660nm and the light both light of wavelength 890nm are used as with time-division (time Division) mode launches the measurement light of light to organism B, and such as detects the intensity of light by the way of with the time-division, Analytic unit 105 can calculate the melanic content included in organism.By generating the attenuation curve of both wavelength, Analytic unit 105 can estimate the decay of the light caused in the light of wavelength 660nm because of melanin, or estimates at wavelength The decay of the light caused because of melanin in the light of 890nm.By being used as to measure light by the light of wavelength 660nm, it is also possible to calculate The thickness of skin corium.It addition, by being used as to measure light by the light of wavelength 940nm, it is possible to obtain about the attenuation curve of fat.Point Analysis unit 105 can also use this attenuation curve to calculate the thickness of fat deposit.

Based on the principle as aforementioned pulse oximeter, by making impact and the venous blood of the internal composition in arterial blood In the impact of internal composition separate, analytic unit 105 can make the variation in time of the composition in arterial blood separate.Therefore, Analysis ingredient more accurately can be carried out in the way of variation in time is the least.

Analytic unit 105 can use the component content calculated by this way or the decay song produced by this way The detection intensity of the light of each wavelength revised by line.Strong by using these component contents or attenuation curve to revise the detection of light Degree, can compensate the impact that the light of internal composition absorbs.

Such as, the decay that directly reflection light is caused by the melanin (that is, nevus and birthmark) because being present in epidermis etc. Impact.Therefore, by estimating the light quantity of produced imaginary source (secondary souce) in health, analytic unit 105 can be repaiied The individual variation just caused because of the state of epidermis.Additionally, by the absorption characteristic utilizing 660nm and 880nm the two wavelength, Melanin can be quantified.Therefore, if light source 111 launches the light with the multiple wavelength including both wavelength, or If person is disposed with the secondary light source 115 of correction as seen in figure 7 c, and analytic unit 105 analyzes obtained result, So analytic unit 105 just can directly modifying factor melanin and the impact that causes.

The scattering coefficient of the subcutaneous layer of fat (body fat layer) in skin texture is about the half of the scattering coefficient of skin corium, Accordingly, it is possible to affect measurement result.Here, for being referred to as the wavelength of the about 700nm to 1000nm of internal optical window, shorter Optical source wavelength can cause the deeper degree of depth, therefore by the measurement result of the light of long wavelength short with arriving distance range for measured value Compare and allow for the influence degree of skin texture and can be estimated.Especially, subcutaneous layer of fat (body fat layer) is at wavelength There is at 940nm absorption characteristic, therefore, obtain dispersion image based on the multiple wavelength being used in combination with this wavelength and calculate difference Point allowing for analytic unit 105 can revise the impact of subcutaneous fat (body fat).

It addition, when skin texture has a small amount of subcutaneous fat, can go out in than the muscular tissue of subcutaneous fat deeper inside Referring now to a large amount of absorptions of the energy measuring light, it is therefore preferred that be modified.Here, it is known that can be based on such as At 940nm, the attenuation characteristic of the specific light source of fat measures the energy absorption in Musclar layer, and analytic unit 105 can Above-mentioned impact is revised by the optical model of organism being estimated as subcutaneous fat layer thickness (body fat thickness).

Light transmission arterial blood, venous blood and the subcutaneous tissue received by whole sensor 131.At with pixel unit Managing the calculating identical with the function of aforementioned pulse oximeter, analytic unit 105 can separate or eliminate tremulous pulse composition.

When there is vein or tremulous pulse in measured part, the optical characteristics in blood is very different, and Analysis result is likely to error occur.Therefore, it is desirable to distinguished point is removed.Therefore, can be as shown in Figure 6 by use Multi-tap sensor obtain whole image, can process according to the analytic unit 105 of the present embodiment.That is, depositing In the part of this blood vessel, it is believed that measurement result is transmitted the most discontinuously.Therefore, analytic unit 105 is had in mind Discontinuity in such measurement data, it is possible to preceding sections is detected as distinguished point, to revise or to delete this part.Similar Ground, analytic unit 105 also is able to revise or delete the distinguished point such as the chaeta on such as surface, birthmark or nevus.

Use the image estimated obtained by 660nm and 890nm both wavelength, according to oxygen-containing in vein or tremulous pulse The increase of amount, analytic unit 105 can estimate the position that there are vein or tremulous pulse, and by coming by dynamic image pro cess Indicating and cause the biggest position because of pulsation, analytic unit 105 can estimate the position that there are vein and tremulous pulse Put.

It addition, by only extracting vein or the composition of tremulous pulse, analytic unit 105 can also estimate the scattering system in each position Number.

If there is the light of the multiple wavelength including above-mentioned wavelength if light source 111 is launched or be disposed with as seen in figure 7 c The secondary light source 115 revised, and analytic unit 105 analyzes obtained result, then be just obtained in that be used for above-mentioned The absorption characteristic of the light with each wavelength of correcting process.

Below the analytic unit 105 according to the present embodiment has been described in detail.

Memory element 107

Return Fig. 4, the memory element 107 in the measurement apparatus 10 being arranged on according to the present embodiment will be illustrated.

Memory element 107 is real by the RAM in the measurement apparatus 10 being arranged on according to the present embodiment or storage device etc. Existing.Memory element 107 store in its own the analyzing and processing that has in analytic unit 105 about optical absorption spectra or The data of light scattering spectrum, the look-up table etc. of various data base.Memory element 107 can store in its own by according to this The measuring unit 101 of embodiment measure the measurement data arrived and for by the control unit 103 according to the present embodiment or Various programs, parameter or the data item etc. of the process performed by analytic unit 105.In addition to storage has data above, storage is single Unit 107 can also store as desired and need, for any process of measurement apparatus 10, each seed ginseng being stored Number, process step etc..Such as each processing unit such as measuring unit 101, control unit 103 or analytic unit 105 is free to Access memory element 107, and data can be write to memory element 107 or read data from memory element 107.

Below with reference to Fig. 4 to Figure 11, the structure of the measurement apparatus 10 according to the present embodiment has been carried out in detail Bright.

Measurement apparatus 10 according to the embodiment above can be estimated exactly and cause optical model (skin texture model) In the internal composition of variation.

Control unit 103 and analytic unit 105 according to the present embodiment can be the measurement dresses according to the present embodiment Put the part of 10, or can be realized by external device (ED)s such as the computers being such as connected to measurement apparatus 10.Single by measuring The measurement data that unit 101 generates is stored in mobile memory medium, and this storage medium can move from measurement apparatus 10 Divided by being just connected to other device with analytic unit 105, such that it is able to measurement data is analyzed.

Hereinbefore, it is shown that according to the function example of the measurement apparatus 10 of the present embodiment.In addition to measuring unit 101 Those described above structure member in each versatile material or universal circuit can be used to be constructed out, or can pass through Hardware that the function of each structure member is special and be constructed out.It addition, CPU etc. can perform all of these structure members Function.Therefore, it is possible to technical merit when implementing the present embodiment suitably changes structure to be used.

Can create and install on personal computer etc. for realize control unit according to the embodiment above and point Analyse the computer program of the function of unit or for controlling the control unit according to the embodiment above and the calculating of analytic unit Machine program.Also being able to, storage is set and has this computer program and the record medium that can be readable by a computer.Such as, this note Recording medium is disk, CD, magneto-optic disk or flash memory etc..It addition, such as, computer program can without using record medium but It is dispensed via network.

The variation of measuring unit 101

Next, with reference to Figure 12, the variation of the measuring unit 101 according to the present embodiment is briefly described.Figure 12 Show for schematically showing another structure of measuring unit 101 included in the measurement apparatus 10 according to the present embodiment The explanatory diagram of example.

As it has been described above, multi-tap sensor is used as detector unit 113, and energy according to the measurement apparatus 10 of the present embodiment Enough bases detect that reflection light is divided into directly reflection light and scatter-type reflection light by the position of the sensor of reflection light.This In, the conventional separation scheme using polarization is combined with the said method being separated into linear type light and scatter-type light, this makes to survey Amount can have more preferable stalling characteristic.

That is, it is schematically shown such as Figure 12, in the surface (being positioned at the downstream of light source 111) of light source 111 and to directly The position of the reflection light sensor that carries out imaging is disposed with polaroid, and makes the polarization direction of these polaroids each other Join, enable to detect more accurately and directly reflect light.

Below with reference to Figure 12, the variation of the measuring unit 101 according to the present embodiment is provided a brief description.

2.2 measuring method

Flow process next, with reference to the Figure 13 measuring method to being performed by the measurement apparatus 10 according to the present embodiment is carried out Brief description.Figure 13 shows the flow chart of the flow example of the measuring method according to the present embodiment.

According in the measuring method of the present embodiment, first, under the control of control unit 103, will have pre-standing wave Long light of measuring launches (step S101) from the light source 111 of measuring unit 101 at least some of of organism.Hereafter, pass through The detector unit 113 of measuring unit 101 detects and straightline propagation occurs in organism or propagates while being scattered Reflection light (step S103).The testing result that will utilize detector unit 113 and obtain exports to analytic unit 105.

The reflection light detected is divided into linear type reflection light and scatter-type reflection by analytic unit 105 according to the method described above Light (step S105).Hereafter, analytic unit 105 uses the linear type reflection light divided and scatter-type reflection light to perform aforesaid Various analyzing and processing (step S107).

Therefore, according in the measuring method of the present embodiment, it is possible to obtain the scattering of internal composition in such as organism The various information such as the component content of coefficient and internal composition.

Below with reference to Figure 13, the flow example of the measuring method according to the present embodiment is provided a brief description.

2.3 hardware construction

Next, with reference to Figure 14, the hardware construction of the measurement apparatus 10 according to embodiment of the present invention is carried out specifically Bright.Figure 14 shows the block diagram of the hardware construction of the measurement apparatus 10 according to embodiment of the present invention.

Measurement apparatus 10 mainly includes CPU 901, ROM 903 and RAM 905.It addition, measurement apparatus 10 also includes main frame Bus 907, bridger 909, external bus 911, interface 913, sensor 914, input equipment 915, output device 917, storage Device 919, driver 921, connectivity port 923 and communicator 925.

CPU 901 serves as arithmetic processing apparatus and controls device, and according to being stored in ROM 903, RAM 905, storage dress Put 919 or movable recording media 927 in various programs and the integrated operation of control and measure device 10 or part operation.ROM 903 store the program used by CPU 901 and operating parameter etc..RAM 905 mainly store the program used by CPU 901 and The term of execution interior optionally parameter etc. changed of these programs.These parts are connected to each other via host bus 907, main Machine bus 907 is constructed out by internal bus such as such as cpu bus.

Host bus 907 be connected to via bridger 909 such as Peripheral Component Interconnect/interface (PCI: Peripheral Component Interconnect/Interface) external bus 911 such as bus.

Sensor 914 is to bio information specific to user or to all kinds for obtaining this bio information Information carries out the detection device detected.Such as, this sensor 914 includes such as charge-coupled image sensor (CCD:Charge Coupled Device) or complementary metal oxide semiconductors (CMOS) (CMOS:Complementary Metal Oxide The various imaging devices such as Semiconductor).Additionally, sensor 914 can have further such as the portion to organism Position carries out optical system or the light sources etc. such as the lens that image.Sensor 914 can also be the microphone etc. for obtaining sound etc.. It should be noted that in addition to those mentioned above, sensor 914 can also include such as thermometer, illumination meter, humidity The various measurement apparatus such as meter, velometer and accelerometer.

Input equipment 915 is the operation device operated by user, such as mouse, keyboard, touch panel, button, switch With control bar etc..It addition, input equipment 915 can be the remote control using such as infrared light or other radio wave (so-called remote controller), or can be that the external connection of the such as operation of the coincidence measurement such as mobile phone or PDA device 10 sets Standby 929.It addition, input equipment 915 is based on such as being produced input letter by user by the information of above operation device input Number, and input equipment 915 is by for constituting the input control circuit of input signal output to CPU 901.Measurement apparatus 10 User various data can be inputted to measurement apparatus 10, and survey can be indicated by operating this input equipment 915 Amount device 10 performs process.

Output device 917 is by the device structure that the information obtained can notify user with visual manner or audible means Become.The example of this device include such as CRT display device, liquid crystal indicator, plasma display system, EL display device and The display devices such as lamp, the such as audio output device such as speaker and earphone, printer, mobile phone, facsimile machine etc..Such as, defeated Go out device 917 and export the various process by being performed by measurement apparatus 10 and the result that obtains.More specifically, display device is with literary composition The form of word or image shows the various process by being performed by measurement apparatus 10 and the result that obtains.On the other hand, audio frequency is defeated Go out device and the audio signals such as the voice data such as regenerated and voice data are converted into analogue signal, and export this simulation letter Number.

Storage device 919 is the device for storing data, and it is configured to measure the example of memory element of device 10 And be used to store data.Such as, storage device 919 is deposited by such as hard disk drive (HDD:Hard Disk Drive) equimagnetic Storage device, semiconductor storage, light storage device or magneto optical storage devices are constituted.This storage device 919 stores by CPU 901 The program performed, various data and the various data that can obtain from outside.

Driver 921 is the read/write device of record medium, and is embedded in measurement apparatus 10 or is attached to from outside to measure Device 10.Driver 921 reads record in the mobile note accompanying by such as disk, CD, magneto-optic disk or semiconductor memory etc. Information in recording medium 927, and the information read is exported to RAM 905.It addition, driver 921 can such as disk, The movable recording media 927 that CD, magneto-optic disk or semiconductor memory etc. are accompanying writes.Such as, moving recording is situated between Matter 927 is dvd media, HD-DVD medium or blu-ray media.Movable recording media 927 can be quick flashing (CF: CompactFlash, registered trade mark), flash memory and secure digital (SD:Secure Digital) storage card.Alternatively, such as, move Dynamic record medium 927 can be equipped with noncontact IC chip integrated circuit (IC:Integrated Circuit) card or For electronic machine.

Connectivity port 923 is so that device can be connected directly to the port of measurement apparatus 10.The example of connectivity port 923 Connect including USB (universal serial bus) (USB:Universal Serial Bus) port, EEE1394 port and minicomputer system Mouth (SCSI:Small Computer System Interface) port etc..Other example of connectivity port 923 includes RS- 232C port, optical fiber audio terminal and HDMI (HDMI:High-Definition Multimedia Interface) port etc..Utilizing the external connection apparatus 929 being connected with this connectivity port 923, measurement apparatus 10 can be from outward Portion connects equipment 929 and directly obtains various data, and provides various data to external connection apparatus 929.

Such as, communicator 925 is by for being connected to the communication interface that the communicator of communication network 931 is constituted.Example If, communicator 925 is wired or wireless LAN (LAN:Local Area Network), bluetooth (Bluetooth, note Volume trade mark) and the communication card etc. of Wireless USB (WUSB:Wireless USB).Alternatively, communicator 925 could be for light Learn the router of communication, for ADSL (ADSL:Asymmetric Digital Subscriber Line) Router with for the various modems etc. communicated.Such as, this communicator 925 can lead to other according to the Internet The predetermined protocols such as the such as TCP/IP between T unit transmit and receive signal etc..It is connected to the communication network of communicator 925 Network 931 is made up of the network etc. wire or wirelessly connected, and such as, this communication network 931 can be the Internet, family LAN, infrared communication, airwave communication and satellite communication etc..

Hereinbefore, it has been shown that be capable of function hard of measurement apparatus 10 according to embodiment of the present invention The example of part structure.Each in said structure parts can use versatile material to constitute, or can be by each structure member The hardware composition that function is special.Therefore, it is possible to suitably change institute according to the technical merit when implementing the present embodiment The hardware construction used.

Although below referring to the drawings the preferred embodiments of the invention are illustrated, but the present invention not office It is limited to above example.In the range of appended claims, those skilled in the art can find various replacement and deformation, and It should be appreciated that these are replaced and deformation nature is in the technical scope of the present invention.

Additionally, effect illustrated in this specification is only exemplary and explanat and nonrestrictive.In other words, Together with or replace effect based on this specification, can show according to the technology of the present invention and show to those skilled in the art And other effect being clear to.

Additionally, this technology can also take following technical scheme.

(1) a kind of measurement apparatus, described measurement apparatus includes:

Light source, described light source is configured to belong to predetermined to by least some of measured zone transmitting formed of organism At least one of wave band measures light；

Detector unit, is arranged with multiple sensor regularly by predetermined deployment in described detector unit, described detection Unit is arranged on the same side with described light source relative to described measured zone, and described detector unit is configured to use institute State multiple sensor and detect the reflection light that the described measurement light of the part through described organism is reflected by described organism； And

Analytic unit, it is configured to use the testing result of the described reflection light detected by described detector unit to divide The scattering properties of the internal composition that analysis is present in described organism.

(2) according to the measurement apparatus described in (1),

Wherein, described analytic unit the described reflection light detected by described detector unit according to the light away from described light source Journey and be divided into when reflected when described organism cathetus is propagated linear type reflection light and when in described organism quilt The scatter-type reflection light reflected during scattering, and detection intensity and the reflection of described scatter-type of light is reflected based on described linear type The detection intensity of light calculates the scattering coefficient of described internal composition.

(3) according to the measurement apparatus described in (1) or (2),

Wherein, described analytic unit comes according to the intensity distributions pattern of the described reflection light detected by described detector unit Calculate the described scattering coefficient of described internal composition.

(4) according to the measurement apparatus described in (2) or (3),

Wherein, described analytic unit uses the described scattering coefficient of the described internal composition calculated to calculate further The component content of described internal composition.

(5) according to (1) to the measurement apparatus according to any one of (4),

Wherein, as described measurement light, launch the light with multiple mutually different wavelength, and

Described analytic unit uses the inspection measuring light with the specific wavelength of the tissue being present in described organism Survey result, revise the impact brought because of described tissue included in described testing result.

(6) according to (1) to the measurement apparatus according to any one of (5),

Wherein, in described detector unit, detect described reflection light by have employed the sensor of microlens array, In described microlens array, multiple lens are arranged in mesh shape regularly.

(7) according to the measurement apparatus described in (6),

Wherein, a pixel of described sensor or multiple pixel are corresponding with each in the plurality of lens, and

Described analytic unit by from the described pixel corresponding with described each lens image perform reversion process and Synthesis, generates the image of the intensity distributions pattern representing described reflection light.

(8) according to the measurement apparatus described in (6) or (7),

Wherein, described analytic unit revises the intensity of described reflection light, institute based on the strength retrogression's information being pre-created State the attenuation characteristic that strength retrogression's information represents the intensity of the described reflection light caused because of described lens.

(9) according to (6) to the measurement apparatus according to any one of (8),

Wherein, described analytic unit selects with described internal composition in described life according to the described internal composition paid close attention to The image that existence position in object is corresponding, and carry out resynthesis so that selected image is connected to each other to continuous print.

(10) according to (6) to the measurement apparatus according to any one of (9),

Wherein, described analytic unit carries out following analyzing and processing: this analyzing and processing is got rid of and causes described internal composition Analysis result the described testing result that the position of described organism of error is corresponding occurs.

(11) according to (1) to the measurement apparatus according to any one of (10), also include:

Secondary light source, described secondary light source is configured to launch second light different from described measurement light,

Wherein, the detection of described detector unit is anti-by described organism through described second light of a part for described organism The reflection light penetrated, this reflection light reflects light as second, and

Described analytic unit uses the testing result of described second reflection light to revise the testing result of described measurement light.

(12) according to (1) to the measurement apparatus according to any one of (11),

Wherein, the wavelength of the described measurement light launched from described light source is controlled according to the described internal composition paid close attention to.

(13) according to (1) to the measurement apparatus according to any one of (12),

Wherein, described internal composition is at least one in melanin, blood constituent and moisture.

(14) a kind of measuring method, described measuring method includes:

From light source at least one being belonged to predetermined band by least some of measured zone transmitting formed of organism Measure light；

Utilization and described light source are arranged on the detector unit of the same side relative to described measured zone, by described detection The multiple sensors arranged regularly by predetermined deployment in unit detect the institute of the part through described organism State and measure the reflection light that light is reflected by described organism；And

The testing result using detected described reflection light analyzes the internal composition being present in described organism Scattering properties.

(15) a kind of program, it is for allowing to a kind of analytic function of computer realization communicated with a kind of measurement module,

Described measurement module includes:

Light source, described light source is configured to belong to predetermined to by least some of measured zone transmitting formed of organism At least one of wave band measures light；And

Detector unit, is arranged with multiple sensor regularly by predetermined deployment in described detector unit, described detection Unit is arranged on the same side with described light source relative to described measured zone, and described detector unit is configured to use institute State multiple sensor and detect the reflection light that the described measurement light of the part through described organism is reflected by described organism,

Described analytic function is: uses the testing result of the described reflection light detected by described detector unit to analyze and deposits The scattering properties of the described internal composition being in described organism,

(16) a kind of record medium, it has program recorded thereon, and described program is for allowing to communicate with a kind of measurement module Computer realizes a kind of analytic function,

Described measurement module includes:

Described analytic function is: uses the testing result of the described reflection light detected by described detector unit to analyze and deposits The scattering properties of the internal composition being in described organism.

Reference numerals list

10 measurement apparatus

101 measuring units

103 control units

105 analytic units

107 memory element

111,115 light source

113 detector units

121 first occulters

123 microlens arrays

125 lenticulees

127 second occulters

129 holes (diaphragm)

131 sensors

Claims

1. a measurement apparatus, including:

Light source, described light source is configured to belong to predetermined band to by least some of measured zone transmitting formed of organism At least one measure light；

Detector unit, is arranged with multiple sensor regularly by predetermined deployment in described detector unit, described detector unit It is arranged on the same side with described light source relative to described measured zone, and described detector unit is configured to use described many Individual sensor detects the reflection light that the described measurement light of the part through described organism is reflected by described organism；And

Analytic unit, described analytic unit is configured to use the detection knot of the described reflection light detected by described detector unit Fruit analyzes the scattering properties of the internal composition being present in described organism.

Measurement apparatus the most according to claim 1, wherein, described analytic unit is the institute detected by described detector unit State reflection light and be divided into reflected when carrying out straightline propagation in described organism straight according to the light path away from described light source Line style reflection light and the scatter-type reflection light reflected when there is scattering in described organism, and based on described linear type The detection intensity of reflection light and the detection intensity of described scatter-type reflection light calculate the scattering coefficient of described internal composition.

Measurement apparatus the most according to claim 2, wherein, described analytic unit is according to being detected by described detector unit The intensity distributions pattern of described reflection light calculates the described scattering coefficient of described internal composition.

Measurement apparatus the most according to claim 3, wherein, described analytic unit uses the described internal composition calculated Described scattering coefficient calculate the component content of described internal composition further.

Measurement apparatus the most according to claim 1, wherein,

As described measurement light, launch the light with multiple mutually different wavelength, and

Described analytic unit uses the detection knot measuring light with the specific wavelength of the tissue being present in described organism Really, the impact brought because of described tissue included in described testing result is revised.

Measurement apparatus the most according to claim 1, wherein, in described detector unit, by have employed microlens array Sensor detect described reflection light, in described microlens array, multiple lens are with latticed and arrange regularly.

Measurement apparatus the most according to claim 6, wherein,

One or more pixels of described sensor are corresponding with each in the plurality of lens, and

Described analytic unit processes and synthesis by the image from the described pixel corresponding with each described lens is performed reversion, Generate the image of the intensity distributions pattern representing described reflection light.

Measurement apparatus the most according to claim 6, wherein, described analytic unit is based on the strength retrogression's information being pre-created Revising the intensity of described reflection light, described strength retrogression's information represents the intensity of the described reflection light caused because of described lens Attenuation characteristic.

Measurement apparatus the most according to claim 6, wherein, described analytic unit comes according to the described internal composition paid close attention to Select the image corresponding with described internal composition existence position in described organism, and carry out resynthesis so that selected Image be connected to each other to continuous print.

Measurement apparatus the most according to claim 6, wherein, the analyzing and processing that the enforcement of described analytic unit is following: this analysis There is the described detection that the position of the described organism of error is corresponding with the analysis result causing described internal composition in process eliminating Result.

11. measurement apparatus according to claim 1, also include:

Wherein, described second light of the part that the detection of described detector unit passes through described organism is reflected by described organism Reflection light, this reflection light reflects light as second, and

12. measurement apparatus according to claim 1, wherein, the described internal composition according to being paid close attention to controls from described The wavelength of the described measurement light that light source is launched.

13. measurement apparatus according to claim 1, wherein, described internal composition is in melanin, blood constituent and moisture At least one.

14. 1 kinds of measuring methods, including:

From light source to being launched at least one measurement belonging to predetermined band by least some of measured zone formed of organism Light；

Utilization and described light source are arranged on the detector unit of the same side relative to described measured zone, by described detector unit In the multiple sensors arranged regularly by predetermined deployment detect the described survey of the part through described organism The reflection light that amount light is reflected by described organism；And

The testing result of the described reflection light detected by utilization analyzes dissipating of the internal composition that is present in described organism Penetrate characteristic.

15. 1 kinds of programs, it is for allowing to a kind of analytic function of computer realization communicated with a kind of measurement module,

Described measurement module includes:

Light source, described light source is configured to belong to predetermined band to by least some of measured zone transmitting formed of organism At least one measure light；And

Detector unit, is arranged with multiple sensor regularly by predetermined deployment in described detector unit, described detector unit It is arranged on the same side with described light source relative to described measured zone, and described detector unit is configured to use described many Individual sensor detects the reflection light that the described measurement light of the part through described organism is reflected by described organism,

Described analytic function is: uses the testing result of the described reflection light detected by described detector unit to analyze and is present in The scattering properties of the internal composition in described organism.

16. 1 kinds record media, and it has program recorded thereon, and described program is for allowing to the computer communicated with a kind of measurement module Realize a kind of analytic function,

Described measurement module includes: