CN106138152A - The new application of Flos Chrysanthemi Indici - Google Patents

The new application of Flos Chrysanthemi Indici Download PDF

Info

Publication number
CN106138152A
CN106138152A CN201510128977.6A CN201510128977A CN106138152A CN 106138152 A CN106138152 A CN 106138152A CN 201510128977 A CN201510128977 A CN 201510128977A CN 106138152 A CN106138152 A CN 106138152A
Authority
CN
China
Prior art keywords
flos chrysanthemi
chrysanthemi indici
decoction liquor
pharmaceutical composition
tumor angiogenesis
Prior art date
Application number
CN201510128977.6A
Other languages
Chinese (zh)
Inventor
钟森
涂翔
Original Assignee
钟森
涂翔
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to CN201510085413 priority Critical
Priority to CN2015100854139 priority
Application filed by 钟森, 涂翔 filed Critical 钟森
Publication of CN106138152A publication Critical patent/CN106138152A/en

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/56Materials from animals other than mammals
    • A61K35/58Reptiles
    • A61K35/586Turtles; Tortoises, e.g. terrapins
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/28Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/28Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A61K36/287Chrysanthemum, e.g. daisy
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/75Rutaceae (Rue family)
    • A61K36/752Citrus, e.g. lime, orange or lemon
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0087Galenical forms not covered by A61K9/02 - A61K9/7023
    • A61K9/0095Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K2236/00Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30Extraction of the material
    • A61K2236/33Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/331Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K2236/00Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/50Methods involving additional extraction steps
    • A61K2236/51Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying

Abstract

The invention discloses the new application of a kind of Flos Chrysanthemi Indici, this new application is Flos Chrysanthemi Indici application in the medicine of suppression tumor angiogenesis.The medicine of suppression tumor angiogenesis is with the Flos Chrysanthemi Indici of effective dose as active component, according to pharmacy conventional method, adds the medicament that pharmaceutically acceptable adjuvant is prepared from.Flos Chrysanthemi Indici is applied to suppress tumor angiogenesis by the present invention, can effectively suppress growth of tumour cell, have good medical value, provide a kind of new selection for clinic.

Description

The new application of Flos Chrysanthemi Indici
Technical field
The invention belongs to field of medicaments, be specifically related to the new application of Flos Chrysanthemi Indici, especially Flos Chrysanthemi Indici at preparation suppression tumor neogenetic blood Purposes in the medicine that pipe generates.
Background technology
Angiogenesis (angiogenesis) is to germinate from existing blood vessel to generate the process of neovascularity.This process is thin with blood vessel endothelium Born of the same parents migrate relevant with propagation.Embryo development procedure is along with angiogenesis.But except wound healing, female menstrual period and some pathology Outward, seldom there is angiogenesis to process (such as cancer) in adult.
Angiogenesis suffers from extremely important meaning to growth, transfer or even the prognosis of malignant entity tumor.Angiogenesis is to dislike Property entity tumor break through after basement membrane of epithelium necessary to further growth.The blood vessel being newly formed in tumor has himself uniqueness Construction features, shows as tube wall imperfect, without smooth muscle elements, is only made up of the basement membrane of porose endotheliocyte and lamellar.Many Number scholar thinks, the construction features of new vessels makes malignant tumor tissue generation metastasis be possibly realized.Therefore, malignant entity In tumor, new vessels is considered as quantitatively a kind of important independent prognostic marker.
Flos Chrysanthemi Indici is the dry capitulum of feverfew Herba Dendranthematis indici, cold nature, bitter in the mouth, pungent.Effect heat-clearing and toxic substances removing, dispelling wind suppressing the hyperactive liver. For furuncle carbuncle, conjunctival congestion and swelling pain, dizziness of having a headache.Usage and dosage 9-15g.Modern study shows, Flos Chrysanthemi Indici can treat respiratory tract Inflammation, cervicitis, carbuncle poison furuncle and phyma, flu, upper respiratory tract infection etc..
Although also it has been reported that it has antitumor action, but not finding that it has the effect of suppression tumor angiogenesis.
Summary of the invention
First technical problem solved by the invention is to provide the new medicine use of a kind of Flos Chrysanthemi Indici.
The new medicine use of Flos Chrysanthemi Indici provided by the present invention is its new use in the medicine of preparation suppression tumor angiogenesis On the way.
Described medicine is with the Flos Chrysanthemi Indici of effective dose as active component, according to pharmacy conventional method, adds adjuvant system pharmaceutically Standby medicament.Concrete can make oral formulations or injection, is inputted or abdomen by oral, intramuscular injection, vein The modes such as chamber injection are administered.
Second technical problem solved by the invention is to provide a kind of pharmaceutical composition suppressing tumor angiogenesis, especially, Its main active is Flos Chrysanthemi Indici, the medicament being prepared from according to pharmacy conventional method.Can also add pharmaceutically during preparation Prepared by customary adjuvant.Active component can also increase the effect of Synergistic with addition of other antineoplastic agents.
Described customary adjuvant include the conventional diluent of pharmaceutical field, excipient, filler, binding agent, wetting agent, disintegrating agent, Absorption enhancer, surfactant, absorption carrier, lubricant etc..
Oral agents, injection etc. can be made for the medicine suppressing tumor angiogenesis prepared by active component many with Flos Chrysanthemi Indici The form of kind.The medicine of above-mentioned various dosage form all can be prepared according to the conventional method of pharmaceutical field.
3rd technical problem solved by the invention is to provide the preparation of the pharmaceutical composition of above-mentioned suppression tumor angiogenesis Method.
Method one: Flos Chrysanthemi Indici is ground into fine powder, mixing powder;Or
Method two: Flos Chrysanthemi Indici is ground into fine powder, encapsulated capsule;Or
Method three: Flos Chrysanthemi Indici is ground into fine powder, tabletting i.e. piece agent;Or
Method four: after Flos Chrysanthemi Indici water boiling and extraction, filters to obtain decoction liquor;Or
Method five: after Flos Chrysanthemi Indici water boiling and extraction, filters to obtain decoction liquor, is dried decoction liquor;Or
Method six: after Flos Chrysanthemi Indici water boiling and extraction, concentrated extracting solution makes granule, granule;Or
Method seven: after Flos Chrysanthemi Indici water boiling and extraction, concentrated extracting solution makes granule, encapsulated capsule;Or
Method eight: after Flos Chrysanthemi Indici water boiling and extraction, concentrated extracting solution makes granule, tabletting i.e. piece agent;Or
Method nine: after Flos Chrysanthemi Indici water boiling and extraction, makes water decoction, or adds customary adjuvant and make oral liquid, syrup, conjunction Agent.
Preferably one of method: comprise the steps:
A, Flos Chrysanthemi Indici boiling, filter to obtain decoction liquor;
B, it is dried decoction liquor and get final product.
Further, step B is dried decoction liquor to water content less than 5%.
Preferably one of method: comprise the steps:
A, Flos Chrysanthemi Indici boiling, filter to obtain decoction liquor;
B, decoction liquor, according to pharmacy conventional method, add customary adjuvant pharmaceutically and are prepared.
Concrete can make oral formulations or injection, the customary adjuvant that can add include the conventional diluent of pharmaceutical field, Excipient, filler, binding agent, wetting agent, disintegrating agent, absorption enhancer, surfactant, absorption carrier, lubricant Deng.
To sum up, the present invention uses Flos Chrysanthemi Indici suppression tumor angiogenesis effect notable, raw for clinic suppression tumor neogenetic blood vessels Become and treatment tumor provides a kind of brand-new selection.
Accompanying drawing explanation
The juvenile fish light microscopic figure that Fig. 1 Flos Chrysanthemi Indici is intervened.
The grayscale format figure of the juvenile fish fluorescence microscope display figure that Fig. 2 Flos Chrysanthemi Indici is intervened.
The grayscale format figure of the juvenile fish high power fluorescence microscope display figure that Fig. 3 Flos Chrysanthemi Indici is intervened.
The juvenile fish light microscopic figure that Fig. 4 positive control-PTK787 intervenes.
The grayscale format figure of the juvenile fish fluorescence microscope display figure that Fig. 5 positive control-PTK787 intervenes.
The grayscale format figure of the juvenile fish high power fluorescence microscope display figure that Fig. 6 positive control-PTK787 intervenes.
The juvenile fish light microscopic figure that Fig. 7 negative control-Vehicle Control (0.1%DMSO) intervenes.
The grayscale format figure of the juvenile fish fluorescence microscope display figure that Fig. 8 negative control-Vehicle Control (0.1%DMSO) intervenes.
The gray scale lattice of the juvenile fish high power fluorescence microscope display figure that Fig. 9 negative control-Vehicle Control (0.1%DMSO) intervenes Formula figure.
Detailed description of the invention
Experimental technique described in following embodiment, if no special instructions, is conventional method;Described reagent and material, as without special Different explanation, the most commercially obtains.
The test investigating the medicinal new application of Flos Chrysanthemi Indici is as follows:
Embodiment:
1. materials and methods
1.1 material
Chinese medicine is purchased from Sichuan return of spring hall Pharmaceuticals Ltd.All reagent be purchased from Sigma-Aldrich Co. (St.Louis, MO), PTK787 (vatalanib) is purchased from Selleckchem.Fli1a-EGFP transgenic zebrafish is used to test.Brachydanio rerio Raise according to standard environment.
1.2 preparation of reagents
Weigh Chinese medicine 450g, 8 times amount soak by water 3 times, each 1 hour, 3 decocting liquid are incorporated on 800W electric furnace dense It is reduced to about 400ml, after crossing 100 eye mesh screens (filtering residue keeps sample), is spread evenly across in evaporating dish, evaporating dish is placed in electric heating drum In wind drying baker, it is interrupted at 60 DEG C after being dried 62 hours, continues at drying at room temperature in glass desicator until making moisture and containing Amount < the extractum of 5% (oven drying method mensuration).
1.3 experimentation
The after fertilization embryo of 22 hours is put into (30, every hole embryo) in 12 orifice plates, use Chinese medicine to intervene 26 hours.Middle liquid medicine carries Thing is dissolved in 0.1% dimethyl sulfoxide (DMSO), and it is 200 μ g/ml that every hole adds water extract of TCM concentration.Positive controls is 5 μ g/ml PTK787 (PTK787 vatalanib, a kind of vascular endothelial growth factor receptor antagonist), negative control group is 0.1% DMSO.After fertilization 48 hours, tricaine anesthesia juvenile fish, use Nikon SMZ 1500 fluorescence microscopy to take pictures.Internode Vascularization is the leading indicator evaluating drug effect, is also used for evaluating its toxicity simultaneously.
1.4 results and conclusion
Use Flos Chrysanthemi Indici, the juvenile fish light microscopic figure of positive control-PTK787, negative control-Vehicle Control intervention, fluorescence microscopy Mirror display figure (grayscale format figure), high power fluorescence microscope display figure (grayscale format figure) are shown in Fig. 1-9 respectively.
The juvenile fish using Flos Chrysanthemi Indici and PTK787 to intervene all occurs in that the defect of angiogenesis.Light microscopic and fluorescence microscope show, with 0.1%DMSO negative control compares, the juvenile fish using Flos Chrysanthemi Indici to intervene, and defines less complete intersegmental blood vessel.High power lens Display, is merely able to observe dorsal aorta Seedling once in a while.5 μ g/ml PTK787 positive controls then can completely inhibit intersegmental blood vessel and the back of the body Portion's longitudinal direction blood vessel.Flos Chrysanthemi Indici is dead or teratogenesis without result in Brachydanio rerio.Do not find neurotoxicity or the organ poison of Flos Chrysanthemi Indici Property.
To sum up, the present invention uses Flos Chrysanthemi Indici suppression tumor angiogenesis effect notable, raw for clinic suppression tumor neogenetic blood vessels Become and treatment tumor provides a kind of brand-new selection.

Claims (9)

1. Flos Chrysanthemi Indici purposes in the medicine of preparation suppression tumor angiogenesis.
Purposes the most according to claim 1, it is characterised in that: described medicine is with the Flos Chrysanthemi Indici of effective dose as activity Composition, the medicament being prepared from according to pharmacy conventional method.
3. suppress the pharmaceutical composition of tumor angiogenesis, it is characterised in that: it is with the Flos Chrysanthemi Indici of effective dose as activity Composition, the medicament being prepared from according to pharmacy conventional method.
The pharmaceutical composition for the treatment of tumor the most according to claim 3, it is characterised in that: described medicament is oral formulations Or injection.
5. according to the pharmaceutical composition of the treatment tumor described in claim 3 or 4, it is characterised in that: the every preparation of described medicament Unit contains Flos Chrysanthemi Indici 1~20 grams.
6. the preparation method of the pharmaceutical composition of the suppression tumor angiogenesis described in claim 3, it is characterised in that: bag Include following steps:
Method one: Flos Chrysanthemi Indici is ground into fine powder, mixing powder;Or
Method two: Flos Chrysanthemi Indici is ground into fine powder, encapsulated capsule;Or
Method three: Flos Chrysanthemi Indici is ground into fine powder, tabletting i.e. piece agent;Or
Method four: after Flos Chrysanthemi Indici water boiling and extraction, filters to obtain decoction liquor;Or
Method five: after Flos Chrysanthemi Indici water boiling and extraction, filters to obtain decoction liquor, is dried decoction liquor;Or
Method six: after Flos Chrysanthemi Indici water boiling and extraction, concentrated extracting solution makes granule, granule;Or
Method seven: after Flos Chrysanthemi Indici water boiling and extraction, concentrated extracting solution makes granule, encapsulated capsule;Or
Method eight: after Flos Chrysanthemi Indici water boiling and extraction, concentrated extracting solution makes granule, tabletting i.e. piece agent;Or
Method nine: after Flos Chrysanthemi Indici water boiling and extraction, makes water decoction, or adds customary adjuvant and make oral liquid, syrup, conjunction Agent.
7. the preparation method of the pharmaceutical composition of the suppression tumor angiogenesis described in claim 3, it is characterised in that: bag Include following steps:
A, Flos Chrysanthemi Indici boiling, filter to obtain decoction liquor;
B, it is dried decoction liquor and get final product.
The preparation method of the pharmaceutical composition of suppression tumor angiogenesis the most according to claim 7, it is characterised in that: Described step B is dried decoction liquor to water content less than 5%.
9. the preparation method of the pharmaceutical composition of the suppression tumor angiogenesis described in claim 3, it is characterised in that: bag Include following steps:
A, Flos Chrysanthemi Indici boiling, filter to obtain decoction liquor;
B, decoction liquor, according to pharmacy conventional method, add customary adjuvant pharmaceutically and are prepared.
CN201510128977.6A 2015-02-17 2015-03-23 The new application of Flos Chrysanthemi Indici CN106138152A (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
CN201510085413 2015-02-17
CN2015100854139 2015-02-17

Publications (1)

Publication Number Publication Date
CN106138152A true CN106138152A (en) 2016-11-23

Family

ID=57014190

Family Applications (10)

Application Number Title Priority Date Filing Date
CN201510127617.4A CN106138144A (en) 2015-02-17 2015-03-23 The new application of Radix Rhapontici seu Radix Echinopsis
CN201510127428.7A CN106138102A (en) 2015-02-17 2015-03-23 The new application of turtle shell
CN201510128977.6A CN106138152A (en) 2015-02-17 2015-03-23 The new application of Flos Chrysanthemi Indici
CN201510127586.2A CN106138344A (en) 2015-02-17 2015-03-23 The new application of rascal
CN201610090382.0A CN105878326A (en) 2015-02-17 2016-02-17 Pharmaceutical composition for inhibiting tumor angiogenesis and preparation method of pharmaceutical composition
CN201610090202.9A CN105878321A (en) 2015-02-17 2016-02-17 Pharmaceutical composition for inhibiting tumor angiogenesis and preparation method of pharmaceutical composition
CN201610090199.0A Active CN105878489B (en) 2015-02-17 2016-02-17 Pharmaceutical composition for inhibiting tumor angiogenesis and preparation method thereof
CN201610089303.4A CN105878325A (en) 2015-02-17 2016-02-17 Pharmaceutical composition for inhibiting tumor angiogenesis and preparation method of pharmaceutical composition
CN201610090372.7A Active CN105878490B (en) 2015-02-17 2016-02-17 Pharmaceutical composition for inhibiting tumor angiogenesis and preparation method thereof
CN201610090180.6A CN105878488A (en) 2015-02-17 2016-02-17 Pharmaceutical composition for inhibiting tumor angiogenesis and preparation method of pharmaceutical composition

Family Applications Before (2)

Application Number Title Priority Date Filing Date
CN201510127617.4A CN106138144A (en) 2015-02-17 2015-03-23 The new application of Radix Rhapontici seu Radix Echinopsis
CN201510127428.7A CN106138102A (en) 2015-02-17 2015-03-23 The new application of turtle shell

Family Applications After (7)

Application Number Title Priority Date Filing Date
CN201510127586.2A CN106138344A (en) 2015-02-17 2015-03-23 The new application of rascal
CN201610090382.0A CN105878326A (en) 2015-02-17 2016-02-17 Pharmaceutical composition for inhibiting tumor angiogenesis and preparation method of pharmaceutical composition
CN201610090202.9A CN105878321A (en) 2015-02-17 2016-02-17 Pharmaceutical composition for inhibiting tumor angiogenesis and preparation method of pharmaceutical composition
CN201610090199.0A Active CN105878489B (en) 2015-02-17 2016-02-17 Pharmaceutical composition for inhibiting tumor angiogenesis and preparation method thereof
CN201610089303.4A CN105878325A (en) 2015-02-17 2016-02-17 Pharmaceutical composition for inhibiting tumor angiogenesis and preparation method of pharmaceutical composition
CN201610090372.7A Active CN105878490B (en) 2015-02-17 2016-02-17 Pharmaceutical composition for inhibiting tumor angiogenesis and preparation method thereof
CN201610090180.6A CN105878488A (en) 2015-02-17 2016-02-17 Pharmaceutical composition for inhibiting tumor angiogenesis and preparation method of pharmaceutical composition

Country Status (1)

Country Link
CN (10) CN106138144A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107281464A (en) * 2017-07-05 2017-10-24 广州中医药大学 A kind of pharmaceutical composition for treating tumour

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106619760A (en) * 2017-01-12 2017-05-10 茂县羌寨农副土特产品开发有限公司 New applications of acanthopanax giraldii harms leaves

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103655547A (en) * 2013-12-18 2014-03-26 成都中医药大学 Novel application of scutellarein

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1223129A (en) * 1998-01-14 1999-07-21 胡安黎 Medicine cauterization and decoction for curing cancer and preparation process
CN1166378C (en) * 2000-11-25 2004-09-15 赵香花 'Tongyuhuazhi' pill
CN1251756C (en) * 2001-12-04 2006-04-19 何文法 Series Chinese medicinal composition for treating tumor
CN1187081C (en) * 2003-04-23 2005-02-02 李健勇 Compound Chinese medicine for treating extensive cancer
CN1679908A (en) * 2005-02-02 2005-10-12 王庆正 Chinese medicine for treating tumor and preparation thereof
CN101073587B (en) * 2006-05-18 2012-07-04 天津天士力制药股份有限公司 Method for separating and extracting Chinese Thorowax Root
CN100444889C (en) * 2007-01-10 2008-12-24 河南太龙药业股份有限公司 Chinese medicinal composition for treating mastopathy
CN101049484A (en) * 2007-05-14 2007-10-10 郝来勤 Strong effective Chinese traditional medicine for treating lung cancer and other various cancers
CN101648002B (en) * 2008-08-13 2013-12-25 北京和润创新医药科技发展有限公司 Medicinal composition for treating skin injury and ulcer and application thereof
CN101670056B (en) * 2008-09-10 2011-08-03 吴昆仑 Medicament for treating malignant tumor
CN101612360B (en) * 2009-07-17 2010-07-21 肖嘉惠 Medicine for treating hepatitis, hepatocirrhosis and liver cancer
CN102370939A (en) * 2010-08-18 2012-03-14 郑国红 Body resistance-strengthening and anticancer traditional Chinese medicine
CN101934025B (en) * 2010-08-18 2011-11-30 赵全会 Traditional Chinese medicine for clearing away heat and toxic material
CN102090819A (en) * 2010-09-08 2011-06-15 成进学 Far infrared anti-electromagnetic wave body-perfuming sleeping bag used for teenagers, comprising nano selenium and traditional Chinese medicinal materials and capable of generating negative ions
CN102178796B (en) * 2011-04-29 2013-02-27 苏州中药研究所 Application of active ingredients of juncus effuses in preparation of medicaments for resisting tumors or inhibiting angiogenesis, health-care food or cosmetics
CN102716423A (en) * 2012-06-21 2012-10-10 刘坤 Ruhesanjie capsule used for curing mammary hyperplasia diseases of women and preparation method thereof
CN103099981B (en) * 2013-02-09 2014-02-19 滨州职业学院 Preparation method of traditional Chinese medicine for treating blepharitis marginalis caused by large moist heat
CN103230556B (en) * 2013-05-15 2015-09-09 周富贵 A kind of Chinese medicine and preparation method thereof for the treatment of liver cirrhosis, hepatocarcinoma
CN103920090A (en) * 2014-03-19 2014-07-16 罗金 Adnexal cyst treatment traditional Chinese medicine composition
CN104055978B (en) * 2014-04-03 2018-03-20 刘黎霞 Treat the Chinese medicine of hyperlipemia
CN105816643A (en) * 2015-01-04 2016-08-03 扬子江药业集团上海海尼药业有限公司 Application of traditional Chinese medicine composition for preventing and treating thyroid nodules

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103655547A (en) * 2013-12-18 2014-03-26 成都中医药大学 Novel application of scutellarein

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
姜英等: "木犀草素下调AEG-1和MMP-2的表达对血管生成和乳腺癌细胞侵袭性的抑制作用", 《生理学报》 *
王晓庆等: "槲皮素抑制血管生成作用的实验研究", 《中国药理学通报》 *
申海进等: "RP-HPLC测定野菊花中槲皮素、木犀草素、芹菜素和刺槐素", 《中国中药杂志》 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107281464A (en) * 2017-07-05 2017-10-24 广州中医药大学 A kind of pharmaceutical composition for treating tumour

Also Published As

Publication number Publication date
CN105878325A (en) 2016-08-24
CN105878489A (en) 2016-08-24
CN105878489B (en) 2020-01-14
CN105878490B (en) 2019-12-31
CN105878488A (en) 2016-08-24
CN106138102A (en) 2016-11-23
CN105878321A (en) 2016-08-24
CN106138344A (en) 2016-11-23
CN105878490A (en) 2016-08-24
CN106138144A (en) 2016-11-23
CN105878326A (en) 2016-08-24

Similar Documents

Publication Publication Date Title
CN104039319B (en) For treating HCV composition and method
CN102172363B (en) SCF extract containing cardiac glycoside
US7438935B2 (en) Pharmaceutical composition for the treatment of cardiovascular and cerebrovascular diseases
JP5832521B2 (en) Uses of cucoamine B
JP6469877B2 (en) Pharmaceutical composition for inhibiting growth of cancer stem cells, comprising an aldehyde inhibitor and a biguanide compound
Li et al. Antitumor activity of celastrol nanoparticles in a xenograft retinoblastoma tumor model
JP5744213B2 (en) Use of arctigenin in the manufacture of a drug for the prevention or treatment of diseases associated with erythropenia
CN100427082C (en) Application of hydroxybenzoate acid and its analogue in the preparing process of medicine for preventing and treating virus infection
CN103919887B (en) A kind of Chinese medicine composition for the treatment of tumor and preparation method thereof
JP2016540833A (en) Broad money sensation total flavonoid capsule, its production method and its application
CN102302737B (en) Traditional Chinese medicine composition for treating gastric cancer
CN102274174B (en) Oil suspension agent of benzimidazole medicine
CN102114044B (en) Artificially processed bear bile powder and preparation method thereof
CN101455736A (en) Wild jujube seeds extract and preparation method and use thereof
CN100522184C (en) Extract with anti-tumor and anti-poisonous activity
CN105727144A (en) Traditional Chinese medicine composition for treating bronchitis and preparation method thereof
CN101721488A (en) Pharmaceutical composition for treating liver diseases and prepration method thereof
EA016653B1 (en) Methods and compositions for inhibiting angiogenesis
WO2016107579A1 (en) Preparation and application of flavonol as brain-targeting synergist
US10799521B2 (en) Use of icaritin in preparing medicament for preventing or treating hematocytopenia
JP2020532501A (en) Use of acteosides in the preparation of drugs to prevent or treat glomerular podocyte injury-type kidney disease
WO2013071696A1 (en) Use of five normal bases in humans for preparation of tumour drugs
CN1788758A (en) Use of traditional Chinese medicine garden burnet and its extract in preparing drug for raising red cell and blood hemoglobin
CN104844600B (en) A kind of tadanafil compound, and combinations thereof
Orhan et al. Preventive treatment of calcium oxalate crystal deposition with immortal flowers

Legal Events

Date Code Title Description
PB01 Publication
C06 Publication
SE01 Entry into force of request for substantive examination
C10 Entry into substantive examination
RJ01 Rejection of invention patent application after publication

Application publication date: 20161123