CN106124751B - Blood cell and analysis of biochemical instrument and method - Google Patents

Blood cell and analysis of biochemical instrument and method Download PDF

Info

Publication number
CN106124751B
CN106124751B CN201610681443.0A CN201610681443A CN106124751B CN 106124751 B CN106124751 B CN 106124751B CN 201610681443 A CN201610681443 A CN 201610681443A CN 106124751 B CN106124751 B CN 106124751B
Authority
CN
China
Prior art keywords
detection
cup
detection cup
biochemical
module
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
CN201610681443.0A
Other languages
Chinese (zh)
Other versions
CN106124751A (en
Inventor
徐新
董自权
曹宁
宋成桥
周强
郭敏
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sinnowa Medical Science and Technology Co Ltd
Original Assignee
Sinnowa Medical Science and Technology Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sinnowa Medical Science and Technology Co Ltd filed Critical Sinnowa Medical Science and Technology Co Ltd
Priority to CN201610681443.0A priority Critical patent/CN106124751B/en
Publication of CN106124751A publication Critical patent/CN106124751A/en
Priority to PCT/CN2017/070576 priority patent/WO2018032720A1/en
Application granted granted Critical
Publication of CN106124751B publication Critical patent/CN106124751B/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/02Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations

Abstract

The invention discloses a kind of blood cell and analysis of biochemical instrument and method, which includes shift module, the first hemolytic agent add module, the second hemolytic agent add module, the 3rd hemolytic agent add module, dilution add module, cleaning agent add module, cleaning module, mixing module, control module, the first detection cup, the second detection cup, the 3rd detection cup and the 4th detection cup.Present invention can be implemented in being rapidly completed on same analyzer, blood cell is conventional and kind more than biochemical project detection so that the detection function of instrument is stronger, sample dosage is less, detection efficiency higher, and more comprehensive information is provided for clinical disease diagnosis.

Description

Blood cell and analysis of biochemical instrument and method
Technical field
The invention belongs to medical test detection technique fields, particularly a kind of blood cell and analysis of biochemical instrument and side Method.
Background technology
In medical clinic applications laboratory is often needed to obtain blood samples of patients haemocyte detection information and biochemistry detection simultaneously Information, the Integrated Checkout information that laboratory provides can provide more perfect tutorial message to clinical disease diagnosis and treatment.
Existing blood cell detection and biochemistry detection are usually to be carried out respectively on blood analyser and Biochemical Analyzer, because It must prepare two parts of blood samples and two different instruments during this detection, operation is relatively complicated, and sample encoded information is in manual delivery In mistake easily occurs, this detection pattern is not particularly suitable for the needs that outpatient service, emergency treatment etc. quickly detect.And existing executable blood The instrument detection project of liquid routine and biochemistry detection is single, and structure is more complicated, and flow is cumbersome.
The content of the invention
Invention is designed to provide a kind of blood cell and analysis of biochemical instrument and method.
Realize the object of the invention technical solution be:A kind of blood cell and analysis of biochemical instrument, including shift module, First hemolytic agent add module, the second hemolytic agent add module, dilution add module, cleaning agent add module, cleaning module, Mixing module, control module, the first detection cup, the second detection cup and the 3rd detection cup;
The shift module is for shifting biochemical reagents and sample, including biochemical reagents position, sample position, suction needle, first Liquid extracting device, connecting line and mobile device;The mobile device is used to drive suction needle in sample position, biochemical reagents It is moved between position, the first detection cup, the second detection cup and the 3rd detection cup;
The first hemolytic agent add module includes the first hemolytic agent position and second liquid draw-out device, for being examined to first It surveys in cup and adds the first hemolytic agent;
The second hemolytic agent add module includes the second hemolytic agent position and the 5th liquid extracting device, for being examined to second It surveys in cup and adds the second hemolytic agent;
The dilution add module includes a dilution liquid level and the 3rd liquid extracting device, for being detected to first Dilution is injected in cup, the second detection cup, the 3rd detection cup, suction needle and suction needle washer;
The cleaning agent add module includes a cleaning agent position and the 4th liquid extracting device, for the first detection cup Cleaning agent is added in the second detection cup;
The cleaning module includes suction needle washer, connecting line, waste liquid discharge pipe and waste drains pump, the suction needle For washer for cleaning suction needle outer wall, the waste liquid discharge pipe is clear for discharging waste liquid and suction needle washer in detection cup The waste liquid generated after washing, the waste drains pump provide power for waste liquid discharge;
The mixing module is by first, second, and third detection cup bottom air-blowing, to the aqueous agitation in detection cup Mixing;
It is respectively arranged on the wall of cup of first detection cup, the second detection cup and the 3rd detection cup and is provided with the first grain count Detection device, the second grain count detection device and the 3rd grain count detection device, the first grain count detection device and Two grain count detection devices are used to carry out liquid in cup karyocyte detection, and the 3rd grain count detection device is used for red Cell and hematoblastic quantity and volume are detected;It is set in one of detection cup of first detection cup and the second detection cup There is transmission optical detection device, detected for hemoglobin, at least one detection cup is set in the first detection cup and the second detection cup There is biochemical detection device, for adding in progress biochemical project detection after biochemical reagents;
The control module is controlling shift module, dilution add module, the first hemolytic agent add module, second molten Blood agent add module, cleaning agent add module, cleaning module, mixing module, the first detection cup, the second detection cup and the 3rd detection Cup work, and perform detection Data Analysis Services, display, printing, output testing result and and external communication.
The present invention also provides a kind of blood cell and analysis of biochemical instrument, are added including shift module, the first hemolytic agent Module, the second hemolytic agent add module, the 3rd hemolytic agent add module, dilution add module, cleaning agent add module, cleaning Module, mixing module, control module, the first detection cup, the second detection cup, the 3rd detection cup and the 4th detection cup;
The shift module is for shifting biochemical reagents and sample, including biochemical reagents position, sample position, suction needle, first Liquid extracting device, connecting line and mobile device;The mobile device is used to drive suction needle in sample position, biochemical reagents It is moved between position, the first detection cup, the second detection cup, the 3rd detection cup and the 4th detection cup;
The first hemolytic agent add module includes the first hemolytic agent position and second liquid draw-out device, for being examined to first It surveys in cup and adds the first hemolytic agent;
The second hemolytic agent add module includes the second hemolytic agent position and the 5th liquid extracting device, for being examined to second It surveys in cup and adds the second hemolytic agent;
The 3rd hemolytic agent add module includes the 3rd hemolytic agent position and the 6th liquid extracting device, for being examined to the 4th It surveys and the 3rd hemolytic agent is added in cup;
The dilution add module includes a dilution liquid level and the 3rd liquid extracting device, for being detected to first Dilution is injected in cup, the second detection cup, the 3rd detection cup, the 4th detection cup, suction needle and suction needle washer;
The cleaning agent add module includes a cleaning agent position and the 4th liquid extracting device, for being detected to first Cleaning agent is added in cup, the second detection cup and the 4th detection cup;
The cleaning module includes suction needle washer, connecting line, waste liquid discharge pipe and waste drains pump, the suction needle For washer for cleaning suction needle outer wall, the waste liquid discharge pipe is clear for discharging waste liquid and suction needle washer in detection cup The waste liquid generated after washing, the waste drains pump provide power for waste liquid discharge;
The mixing module is by the bottom air-blowing of first, second, third and fourth detection cup, to the liquid in detection cup Stir mixing;
First detection cup, the second detection cup, the 3rd detection cup and the 4th detection cup wall of cup on be respectively arranged with and be provided with First grain count detection device, the second grain count detection device, the 3rd grain count detection device and the 4th grain count Detection device, the first grain count detection device, the second grain count detection device and the 4th grain count detection device are used for Karyocyte detection is carried out to liquid in cup, the 3rd grain count detection device is used for red blood cell and hematoblastic quantity and body Product is detected;Transmitted light inspection is provided in one of detection cup of first detection cup, the second detection cup and the 4th detection cup Device is surveyed, is detected for hemoglobin, at least one detection cup is set in the first detection cup, the second detection cup and the 4th detection cup There is biochemical detection device, for adding in progress biochemical project detection after biochemical reagents;
The control module is controlling shift module, dilution add module, the first hemolytic agent add module, second molten Blood agent add module, the 3rd hemolytic agent add module, cleaning agent add module, cleaning module, mixing module, the first detection cup, Second detection cup, the 3rd detection cup and the work of the 4th detection cup, and perform detection Data Analysis Services, display, printing, output inspection Survey result and and external communication.
The present invention also provides the analysis method of a kind of blood cell and analysis of biochemical instrument, this method includes following step Suddenly:
Step 1 quantitatively draws whole blood sample by suction needle from specimen cup, is quantitatively transferred to the first detection cup, second In detection cup and the 4th detection cup, dilution add module is distinguished into the first detection cup, the second detection cup and the 4th detection cup Quantitative dilution is added in, and passes through the first detection cup of mixing module mixing, the second detection cup and the 4th detection cup;By inhaling sample Pin washer cleans suction needle outer wall;
Step 2, after drawing quantitative dilution, mixing from the first, second, the 4th any one cup of detection cup by suction needle Blood sample be transferred to the 3rd detection cup, mixed with the dilution in cup, by mixing module to liquid blending in the 3rd detection cup, Three grain count detection devices carry out red blood cell and platelets analysis to blood sample after mixing in the 3rd detection cup;It is clear by suction needle Device is washed to clean suction needle outer wall;
Step 3 adds in the first quantitative hemolytic agent by the first hemolytic agent add module and through mixed into the first detection cup Even module examines liquid blending in the first detection cup, the first grain count detection device and transmission optical detection device to first respectively Karyocyte and hemoglobin after survey cup mixing in blood sample are detected;
Step 4 adds in the second hemolytic agent, the second grain count into the second detection cup by the second hemolytic agent adding set Detection device is detected karyocyte;
Step 5 adds in the 3rd hemolytic agent, the 4th grain count by the 3rd hemolytic agent adding set into the 4th detection cup Detection device is detected karyocyte;
Suction needle after step 6, cleaning is moved to biochemical reagents position, draws the first quantitative biochemical reagents and is transferred to First detection cup, liquid in the first detection cup of mixing again, by the first biochemical detection device to adding in mixing after biochemical reagents Dilute sample be detected, obtain the testing result of corresponding biochemical project;
Suction needle after step 7, cleaning is moved to the second biochemical reagents position again, draws second quantitative of biochemical reagents and adds To the second detection cup, second of biochemical project is performed by the second biochemical detection device and is detected;Suction needle after cleaning is quantitatively inhaled The third biochemical reagents is taken, adds in the 4th detection cup, performing the third biochemical project by the 3rd biochemical detection device detects.
Compared with the prior art and product, remarkable result of the invention is:(1) present invention uses a whole blood sample one Blood routine and multinomial biochemistry detection are rapidly completed on platform instrument, the part flow of original respective independent detection process is effective It integrates, avoids the repetition of part flow, enormously simplify operation sequence, save detection time;(2) present invention is only used only Whole blood can complete biochemical project detection, and eliminate whole blood sample detection biochemical composition by the modification method of the present invention With the difference of the biochemistry detection result of serum/plasma sample, it is ensured that testing result is accurate and can be with classical biochemistry detection side Method compares;(3) the analyzer overall structure that uses of the present invention is simple, only one suction needle can complete whole samples and The transfer or distribution of biochemical reagents;(4) the required sample of this instrument detection is less, cell detection and biochemical inspection in detection process It surveys and shares sample, dilution and cleaning reagent, therefore the waste liquid generated is less, it is more environmentally friendly.
Description of the drawings
Fig. 1-1 is sample position Cs, the first biochemical reagents position R1, the first detection cup C1, the second detection cup C2 and the 3rd are detected Mutual alignment relation schematic diagram and suction needle movement locus schematic diagram between cup C3.
Fig. 1-2 is sample position Cs, the first biochemical reagents position R1, the second biochemical reagents position R1 ', the first detection cup C1, second Mutual alignment relation schematic diagram and suction needle movement locus between detection cup C2, the 4th detection cup C4 and the 3rd detection cup C3 are shown It is intended to.
Fig. 1-3 for sample position Cs, the first biochemical reagents position R1, the second biochemical reagents position R1 ', the 3rd biochemical reagents position R1 ", Mutual alignment relation schematic diagram between first detection cup C1, the second detection cup C2, the 4th detection cup C4 and the 3rd detection cup C3 And suction needle movement locus schematic diagram.
Fig. 1-4 for sample position Cs, the first detection cup C1, the second detection cup C2, the 4th detection cup C4, the 3rd detection cup C3, Mutual alignment relation schematic diagram between first biochemical reagents position R1, the second biochemical reagents position R1 ' and the 3rd biochemical reagents position R1 " And suction needle movement locus schematic diagram.
Fig. 1-5 for sample position Cs, the first detection cup C1, the second detection cup C2, the 4th detection cup C4, the 3rd detection cup C3, Mutual alignment relation schematic diagram between first biochemical reagents position R1, the second biochemical reagents position R1 ' and the 3rd biochemical reagents position R1 " And suction needle movement in a curve track schematic diagram.
Fig. 2 is four detection cup schematic diagrames of the invention.
Fig. 3-1~Fig. 3-3 is the first detection cup top view of the invention.
Fig. 4 is analyzer structure diagram of the present invention.
Fig. 5 detects CRP results relevance analysis charts for existing biochemical instruments and analyzer of the present invention.
Fig. 6 detects HbA1c results relevance analysis charts for existing biochemical instruments and analyzer of the present invention.
Specific embodiment
The invention will be further described in the following with reference to the drawings and specific embodiments.
The present invention a kind of blood cell and analysis of biochemical instrument, including shift module, the first hemolytic agent add module, Second hemolytic agent add module, dilution add module, cleaning agent add module, cleaning module, mixing module, control module, First detection cup, the second detection cup and the 3rd detection cup;
The shift module is for shifting biochemical reagents and sample, including biochemical reagents position, sample position, suction needle, first Liquid extracting device, connecting line and mobile device;The mobile device is used to drive suction needle in sample position, biochemical reagents It is moved between position, the first detection cup, the second detection cup and the 3rd detection cup;
The first hemolytic agent add module includes the first hemolytic agent position and second liquid draw-out device, for being examined to first It surveys in cup and adds the first hemolytic agent;
The second hemolytic agent add module includes the second hemolytic agent position and the 5th liquid extracting device, for being examined to second It surveys in cup and adds the second hemolytic agent;
The dilution add module includes a dilution liquid level and the 3rd liquid extracting device, for being detected to first Dilution is injected in cup, the second detection cup, the 3rd detection cup, suction needle and suction needle washer;
The cleaning agent add module includes a cleaning agent position and the 4th liquid extracting device, for the first detection cup Cleaning agent is added in the second detection cup;
The cleaning module includes suction needle washer, connecting line, waste liquid discharge pipe and waste drains pump, the suction needle For washer for cleaning suction needle outer wall, the waste liquid discharge pipe is clear for discharging waste liquid and suction needle washer in detection cup The waste liquid generated after washing, the waste drains pump provide power for waste liquid discharge;
The mixing module is by first, second, and third detection cup bottom air-blowing, to the aqueous agitation in detection cup Mixing;
It is respectively arranged on the wall of cup of first detection cup, the second detection cup and the 3rd detection cup and is provided with the first grain count Detection device, the second grain count detection device and the 3rd grain count detection device, the first grain count detection device and Two grain count detection devices are used to carry out liquid in cup karyocyte detection, and the 3rd grain count detection device is used for red Cell and hematoblastic quantity and volume are detected;It is set in one of detection cup of first detection cup and the second detection cup There is transmission optical detection device, detected for hemoglobin, at least one detection cup is set in the first detection cup and the second detection cup There is biochemical detection device, for adding in progress biochemical project detection after biochemical reagents;
The control module is controlling shift module, dilution add module, the first hemolytic agent add module, second molten Blood agent add module, cleaning agent add module, cleaning module, mixing module, the first detection cup, the second detection cup and the 3rd detection Cup work, and perform detection Data Analysis Services, display, printing, output testing result and and external communication.
The present invention also provides a kind of blood cell and analysis of biochemical instrument, are added including shift module, the first hemolytic agent Module, the second hemolytic agent add module, the 3rd hemolytic agent add module, dilution add module, cleaning agent add module, cleaning Module, mixing module, control module, the first detection cup, the second detection cup, the 3rd detection cup and the 4th detection cup;
The shift module is for shifting biochemical reagents and sample, including biochemical reagents position, sample position, suction needle, first Liquid extracting device, connecting line and mobile device;The mobile device is used to drive suction needle in sample position, biochemical reagents It is moved between position, the first detection cup, the second detection cup, the 3rd detection cup and the 4th detection cup;
The first hemolytic agent add module includes the first hemolytic agent position and second liquid draw-out device, for being examined to first It surveys in cup and adds the first hemolytic agent;
The second hemolytic agent add module includes the second hemolytic agent position and the 5th liquid extracting device, for being examined to second It surveys in cup and adds the second hemolytic agent;
The 3rd hemolytic agent add module includes the 3rd hemolytic agent position and the 6th liquid extracting device, for being examined to the 4th It surveys and the 3rd hemolytic agent is added in cup;
The dilution add module includes a dilution liquid level and the 3rd liquid extracting device, for being detected to first Dilution is injected in cup, the second detection cup, the 3rd detection cup, the 4th detection cup, suction needle and suction needle washer;
The cleaning agent add module includes a cleaning agent position and the 4th liquid extracting device, for being detected to first Cleaning agent is added in cup, the second detection cup and the 4th detection cup;
The cleaning module includes suction needle washer, connecting line, waste liquid discharge pipe and waste drains pump, the suction needle For washer for cleaning suction needle outer wall, the waste liquid discharge pipe is clear for discharging waste liquid and suction needle washer in detection cup The waste liquid generated after washing, the waste drains pump provide power for waste liquid discharge;
The mixing module is by the bottom air-blowing of first, second, third and fourth detection cup, to the liquid in detection cup Stir mixing;
First detection cup, the second detection cup, the 3rd detection cup and the 4th detection cup wall of cup on be respectively arranged with and be provided with First grain count detection device, the second grain count detection device, the 3rd grain count detection device and the 4th grain count Detection device, the first grain count detection device, the second grain count detection device and the 4th grain count detection device are used for Karyocyte detection is carried out to liquid in cup, the 3rd grain count detection device is used for red blood cell and hematoblastic quantity and body Product is detected;Transmitted light inspection is provided in one of detection cup of first detection cup, the second detection cup and the 4th detection cup Device is surveyed, is detected for hemoglobin, at least one detection cup is set in the first detection cup, the second detection cup and the 4th detection cup There is biochemical detection device, for adding in progress biochemical project detection after biochemical reagents;
The control module is controlling shift module, dilution add module, the first hemolytic agent add module, second molten Blood agent add module, the 3rd hemolytic agent add module, cleaning agent add module, cleaning module, mixing module, the first detection cup, Second detection cup, the 3rd detection cup and the work of the 4th detection cup, and perform detection Data Analysis Services, display, printing, output inspection Survey result and and external communication.
Further, it is provided on the first detection cup wall of cup and transmits optical detection device and the first biochemical detection device, second The second biochemical detection device is provided on detection cup wall of cup, the 3rd biochemical detection device is provided on the 4th detection cup wall of cup.
Further, the biochemical detection device include transmission optical detection device and scatter optical detection device in one kind or Two kinds.
Further, analyzer further includes to clean the washer of suction needle outer wall.
Further, the scattering optical detection device and transmission optical detection device are multi-wavelength detection device.
Instrument needs wavelength switching according to detection, and the switching of Detection wavelength passes through toggle lights, switching voltage or detector The monochromator device that preceding installation can change wavelength is realized.
Further, analyzer further includes a Washing cup, for being cleaned to suction needle inside and outside.
The present invention also provides a kind of analysis method based on blood cell and analysis of biochemical instrument, this method includes following Step:
Step 1 quantitatively draws whole blood sample by suction needle from specimen cup, is quantitatively transferred to the first detection cup, second In detection cup and the 4th detection cup, dilution add module is distinguished into the first detection cup, the second detection cup and the 4th detection cup Quantitative dilution is added in, and passes through the first detection cup of mixing module mixing, the second detection cup and the 4th detection cup;By inhaling sample Pin washer cleans suction needle outer wall;
Step 2, after drawing quantitative dilution, mixing from the first, second, the 4th any one cup of detection cup by suction needle Blood sample be transferred to the 3rd detection cup, mixed with the dilution in cup, by mixing module to liquid blending in the 3rd detection cup, Three grain count detection devices carry out red blood cell and platelets analysis to blood sample after mixing in the 3rd detection cup;It is clear by suction needle Device is washed to clean suction needle outer wall;
Step 3 adds in the first quantitative hemolytic agent by the first hemolytic agent add module and through mixed into the first detection cup Even module examines liquid blending in the first detection cup, the first grain count detection device and transmission optical detection device to first respectively Karyocyte and hemoglobin after survey cup mixing in blood sample are detected;
Step 4 adds in the second hemolytic agent, the second grain count into the second detection cup by the second hemolytic agent adding set Detection device is detected karyocyte;
Step 5 adds in the 3rd hemolytic agent, the 4th grain count by the 3rd hemolytic agent adding set into the 4th detection cup Detection device is detected karyocyte;
Suction needle after step 6, cleaning is moved to biochemical reagents position, draws the first quantitative biochemical reagents and is transferred to First detection cup, liquid in the first detection cup of mixing again, by the first biochemical detection device to adding in mixing after biochemical reagents Dilute sample be detected, obtain the testing result of corresponding biochemical project;
Suction needle after step 7, cleaning is moved to the second biochemical reagents position again, draws second quantitative of biochemical reagents and adds To the second detection cup, second of biochemical project is performed by the second biochemical detection device and is detected;Suction needle after cleaning is quantitatively inhaled The third biochemical reagents is taken, adds in the 4th detection cup, performing the third biochemical project by the 3rd biochemical detection device detects.
Instrument carries out clearly each detection cup, suction needle by cleaning module, dilution add module after completing all detections It washes, instrument completes this testing process.
Karyocyte includes basophilic granulocyte, eosinophil, lymphocyte, monocyte, neutrality in the present invention Granulocyte detects and granulophilocyte.The determination method of karyocyte can be electrical impedance method, electrical impedance combination sheath streamer Learn detection method or simple cell dyeing sheath stream technology detecting method.
Discrepant biochemistry detecting item is detected for whole blood sample and serum/plasma, instrument can be automatically to each blood sample Biochemical composition testing result is modified, it is ensured that the life of each biochemistry detection result of the instrument and real biochemical composition or standard It is consistent to change testing result, does not have discrepant biochemical project for serum/plasma detection and whole blood test, instrument is detected without correcting As a result.Modified principle is since the biochemistry detection of standard is the biochemistry ingredient content that detects in plasma/serum, and is contained in whole blood There are a large amount of Cell Components, and part biochemical composition has differences outside in the cell;Part biochemical composition only/be primarily present in blood Liquid is intracellular;Part biochemical composition is primarily present in outside blood cell, therefore whole blood sample biochemistry ingredient content and plasma/serum There may be differences;In addition in whole blood red blood cell, leucocyte, blood platelet composition also assist in biochemical project detection when, the part into Part can also detect corresponding biochemical project and have some impact on.Therefore the life of whole blood sample biochemistry detection result and plasma/serum Changing testing result, there are errors.
To eliminate these errors, instrument of the present invention is to testing result according to equation below amendment:
Wherein, serum/plasma volume=volume of whole blood-cell volume, platelet counts × blood in cell volume=whole blood Quantity of leucocyte × whole leucocyte is put down in erythrocyte number × average volume of red blood cells+whole blood in platelet average external volume+whole blood Equal volume × modifying factor b, the scope of modifying factor a and b are respectively 0.3-4.0.In the present invention, "/" represents the meaning of "or".
The volume of leucocyte can be calculated according to equation below:
(1) leucocyte volume=big leucocyte average external volume × big quantity of leucocyte × modifying factor c+ small white blood cells volumes × small white blood cells quantity × modifying factor d, the scope of modifying factor c and d are respectively 0.3-4.0.
(2) leucocyte volume=lymphocyte average external volume × lymphocyte quantity × modifying factor e+ neutrophil leucocyte bodies Product × neutrophil leucocyte quantity × modifying factor f+ intermediate cells volume × intermediate cell quantity × modifying factor g, modifying factor The scope of e-g is respectively 0.3-4.0.
The sample position of blood cell and analysis of biochemical instrument and method, each detection cup, biochemical reagents position are designed and are being inhaled In sample pin motion track, Fig. 1-1 to Fig. 1-5 is several specific layout type:
Fig. 1-1:Sample needle motion track is detection cup C1 → the second of the biochemical reagents position R1 of sample position Cs → first → first The detection cup C3 of detection cup C2 → the 3rd;
Fig. 1-2:Sample needle motion track for the biochemical reagents position R1 ' of the biochemical reagents position R1 of sample position Cs → first → second → The detection cup C3 of the detection cup C4 of the detection cup C2 of first detection cup C1 → second → the 4th → the 3rd;
Fig. 1-3:Sample needle motion track for the biochemical reagents position R1 ' of the biochemical reagents position R1 of sample position Cs → first → second → The detection cup C3 of the detection cup C4 of the detection cup C2 of the detection cup C1 of 3rd biochemical reagents position R1 " → first → second → the 4th → the 3rd;
Fig. 1-4 and Fig. 1-5:Sample needle motion track is detection cup C2 → the of the detection cup C1 of sample position Cs → first → second The biochemical reagents position of the biochemical reagents position R1 ' of the biochemical reagents position R1 of the detection cup C3 of four detection cup C4 → the 3rd → first → second → the 3rd R1”。
With reference to specific embodiment, the invention will be further described.
Embodiment 1
The present embodiment detects blood routine and single reagent biochemical project by taking four detection cups as an example.
As shown in Fig. 2, the first detection cup C1 is provided with the first grain count detection device D4, the first transmission optical detection device With the first biochemical detection device, the first biochemical detection device includes the first scattering optical detection device;First transmission optical detection device Including the first transmission radiant L1;First scattering optical detection device includes the first scattering radiant L4, the first scattering light detection dress It puts and shares the first detector D1 with the first transmission optical detection device.
Second detection cup C2 is provided with the second grain count detection device D5 and the second biochemical detection device, the second biochemical inspection Surveying device includes the second transmission optical detection device and the second scattering optical detection device.Second transmission optical detection device and the second scattering One of open of optical detection device selection carries out biochemical project detection;Second transmission optical detection device includes the second transmitted light light Source L2, the second scattering optical detection device include the second scattering radiant L5, and the second scattering optical detection device and the second transmitted light are examined It surveys device and shares the second detector D2;
4th detection cup C4 is equipped with the 4th grain count detection device D6 and the 3rd biochemical detection device, and the described 3rd is biochemical Detection device includes the 3rd transmission optical detection device and the 3rd scattering optical detection device, and the 3rd transmission optical detection device and the 3rd dissipates It penetrates one of open of optical detection device selection and carries out biochemical project detection;3rd transmission optical detection device includes the 3rd transmitted light Light source L3, the 3rd scattering optical detection device include the 3rd scattering radiant L6, the 3rd transmission optical detection device and the 3rd scattering light Detection device shares the 3rd detector D3;
3rd detection cup C3 is provided with the 3rd grain count detection device D7.
As shown in figure 4, suction needle N1 is moved in specimen cup, the second valve V2 is closed, the first valve V1 is opened, the first liquid Body draw-out device S1 pistons are pulled back, and in quantitative sample sucking suction needle N1, mobile device drives N1 to be moved to the first detection cup C1, Second valve V2 is closed, and the first valve V1 is opened, and the propulsion of the first liquid extracting device S1 pistons adds in blood sample in suction needle N1 Into the first detection cup C1;According to same method, suction needle N1 is moved in the second detection cup C2 and the 4th detection cup C4, will be fixed Amount blood sample is separately added into the second detection cup C2 and the 4th detection cup C4;The 6th valve V6 is opened in dilution add module, and second Valve V2, the 24th valve V24, the 20th valve V20, the 21st valve V21 and the 5th valve V5 are closed, the 3rd liquid Draw-out device S3 pistons, which are pulled back, sucks dilution R3 in the 3rd liquid extracting device S3, and the 6th valve V6 is closed, the 20th valve Door V20, the 21st valve V21, the 24th valve V24 are opened, and the 3rd liquid extracting device S3 pistons promote, then former sucking Dilution in 3rd liquid extracting device S3 is along the first dilution pin N31Into the first detection cup C1, along the second dilution pin N32Into the second detection cup C2, along the 3rd dilution pin N33Into the 4th detection cup C4;In mixing module the tenth valve V10 and 12nd valve V12 is closed, and the 9th valve V9, the 22nd valve V22, the 23rd valve V23 and the 11st valve V11 are opened It opens, air pump P1 air-blowing, driving gas enters the first detection cup C1, the second detection cup C2 and the 4th detection cup C4 bottoms along pipeline Portion, liquid in mixing cup.
Suction needle N1 according to previous mode the diluted sample after the mixing of part is drawn from the first detection cup C1, be transferred to Three detection cup C3, the 6th valve V6 is opened in dilution add module, the second valve V2, the 24th valve V24, the 20th valve Door V20, the 21st valve V21 and the 5th valve V5 are closed, the 3rd liquid extracting device S3 pistons pull back draw it is quantitative dilute It releases liquid R3, the 6th valve V6, the 24th valve V24, the 20th valve V20 and the 21st valve V21 to close, the 5th valve V5, the first valve V1 and the second valve V2 are opened, and the 3rd liquid extracting device S3 pistons are promoted the 3rd liquid extracting device S3 In quantitative dilution the 3rd detection cup C3 is injected by the 4th dilution pin pin N3, while suction needle N1 is entered by pipeline, To being cleaned inside suction needle N1.9th valve V9 in mixing module, the 22nd valve V22, the 23rd valve V23 and 12nd valve V12 is closed, and the tenth valve V10 and the 11st valve V11 are opened, air pump P1 air-blowing, drives gas along pipeline Into the 3rd detection cup C3 bottoms, liquid in mixing cup.3rd grain count detection device D7 is to sample in the 3rd detection cup C3 The quantity and volume of blood platelet and red blood cell are detected.
The outer washer of pin outside suction needle N1 to cleaning.The 4th valve V4 is opened afterwards, and the 3rd valve V3 is closed, the Two liquid extracting device S2 pull back, and in the first hemolytic agent R2 sucking second liquid draw-out devices S2, the 4th valve V4 is closed, and the 3rd Valve V3 is opened, and second liquid draw-out device S2 pistons promote, and quantitative first hemolytic agent is made to enter the first detection cup C1.Mixing mould The 11st valve V11 and the 9th valve V9 is opened in block, the tenth valve V10, the 22nd valve V22, the 23rd valve V23 It is closed with the 12nd valve V12, air pump P1 air-blowing, driving gas is along pipeline into the first detection cup C1 bottoms, in mixing cup Liquid.The first grain count detection device D4 is detected karyocyte in cup in first detection cup C1, the first transmitted light light Source L1 is opened, and the first detector D1 is detected content of hemoglobin.
Suction needle N1 is moved at the first biochemical reagents position R1, and suction needle N1 gos deep into the first biochemical reagents, in the first liquid Under body draw-out device S1, the first valve V1 and the second valve V2 cooperations, by drawing quantitative first life in the first biochemical reagents position R1 Change reagent, suction needle N1 is moved at the first detection cup C1 afterwards, and the first biochemical reagents are added in the first detection cup C1, mixing mould The 11st valve V11 and the 9th valve V9 is opened in block, the tenth valve V10, the 22nd valve V22, the 23rd valve V23 It is closed with the 12nd valve V12, air pump P1 air-blowing, driving gas is along pipeline into the first detection cup C1 bottoms, in mixing cup Liquid.If Fig. 2, the first scattering radiant L4 are opened, the first transmission radiant L1 is closed, the first detector D1 detection scattering light letters Number, obtain single reagent biochemical project testing result.
The outer washer of pin outside suction needle N1 to cleaning.The 13rd valve V13 is opened afterwards, the 14th valve V14 It closes, the 5th liquid extracting device S5 pulls back, and the second hemolytic agent R5 is sucked in the 5th liquid extracting device S5, the 13rd valve V13 is closed, and the 14th valve V14 is opened, and the 5th liquid extracting device S5 pistons promote, and quantitative second hemolytic agent is made to enter second Detection cup C2.The 11st valve V11 and the 22nd valve V22 is opened in mixing module, the 9th valve V9, the 23rd valve V23, the tenth valve V10 and the 12nd valve V12 are closed, and air pump P1 air-blowing, driving gas enters the second detection cup along pipeline C2 bottoms, liquid in mixing cup.Second grain count detection device D5 is detected part karyocyte in cup.
The 15th valve V15 is opened afterwards, and the 16th valve V16 is closed, and the 6th liquid extracting device S6 pulls back, and the 3rd is molten Blood agent R6 is sucked in the 6th liquid extracting device S6, and the 15th valve V15 is closed, and the 16th valve V16 is opened, and the 6th liquid is taken out Device S6 pistons is taken to promote, quantitative 3rd hemolytic agent is made to enter the 4th detection cup C4.11st valve V11 and in mixing module 23 valve V23 are opened, and the 9th valve V9, the 22nd valve V22, the tenth valve V10 and the 12nd valve V12 are closed, Air pump P1 air-blowing, driving gas is along pipeline into the 4th detection cup C4 bottoms, liquid in mixing cup.4th grain count detects Device D6 is detected part karyocyte in cup.
After detection, the 9th valve V9, the 22nd valve V22, the 23rd valve V23, the tenth valve V10 are opened It is evacuated with the 12nd valve V12, waste drains pump P2, waste liquid will be detected in washer outside each detection cup, pin and pipeline and is discharged into waste liquid receipts In storage;The 8th valve V8 in cleaning agent add module is opened afterwards, and the 7th valve V7 is closed, the 4th liquid extracting device S4 It pulls back, cleaning agent R4 sucks the 4th liquid extracting device S4, and the 8th valve V8 is closed afterwards, the 7th valve V7, the 17th valve V17, the 18th valve V18 and the 19th valve V19 are opened, and the 4th liquid extracting device S4 is promoted, and cleaning agent R4 passes through first Cleaning agent pin N4 enters the first detection cup C1, passes through the second cleaning agent pin N41Into the second detection cup C2, pass through the 3rd cleaning agent Pin N42Into the 4th detection cup C4, the 9th valve V9 is opened afterwards, the 22nd valve V22, the 23rd valve V23 and the 12 valve V12, waste drains pump P2 are evacuated, and cleaning waste liquid is discharged into liquid waste collector.
6th valve V6 of dilution add module is opened, the second valve V2, the 24th valve V24, the 20th valve V20, the 21st valve V21 and the 5th valve V5 are closed, and the 3rd liquid extracting device S3 pistons, which are pulled back, draws quantitative dilution Liquid R3, afterwards the 6th valve V6 closings, the 5th valve V5, the 20th valve V20, the 21st valve V21, the 24th valve V24, the first valve V1 and the second valve V2 are opened, and the 3rd liquid extracting device S3 pistons are promoted the 3rd liquid extracting device S3 In quantitative dilution by the 4th dilution pin N3 into the 3rd detection cup C3, pass through the first dilution pin N31Into first Detection cup C1 passes through the second dilution pin N32Into the second detection cup C2, pass through the 3rd dilution pin N33Into the 4th detection cup In C4, while suction needle N1 is entered by pipeline, to being cleaned inside each detection cup and suction needle N1.Suction needle N1 is at this time Pin exterior washings are performed, the 9th valve V9 of opening, the 22nd valve V22, the 23rd valve V23 after cleaning, the tenth Valve V10 and the 12nd valve V12, waste drains pump P2 are evacuated, and cleaning waste liquid is discharged into liquid waste collector.
Embodiment 2
With reference to Fig. 2 and Fig. 4, difference lies in detect blood routine to the analyzer of the present embodiment with embodiment 1 in the present embodiment With double reagent biochemical project.
Suction needle N1 is moved at the first biochemical reagents position R1, and suction needle N1 gos deep into the first biochemical reagents, in the first liquid Under body draw-out device S1, the first valve V1 and the second valve V2 cooperations, quantitative first biochemical reagents are drawn, suction needle N1 is moved afterwards It moves to the first detection cup C1, the first biochemical reagents is added in into the first detection cup C1, the 11st valve V11 and the in mixing module Nine valve V9 are opened, and the tenth valve V10, the 22nd valve V22, the 23rd valve V23 and the 12nd valve V12 are closed, Air pump P1 air-blowing, driving gas is along pipeline into the first detection cup C1 bottoms, liquid in mixing cup.Suction needle N1 is moved afterwards To the second biochemical reagents position R1 ', draw quantitative second biochemical reagents according to the same manner and be transferred to the first detection cup C1, press After liquid in aforesaid way mixing cup, the first scattering radiant L4 is opened, and the first transmission radiant L1 is closed, the first detector D1 detects scattered light signal, obtains the testing result of double reagent biochemical project.
Embodiment 3
Difference lies in the first transmission radiant L1 is opened, the first scattering light for the present embodiment and embodiment 1 and embodiment 2 Light source L4 is closed, and the first detector D1 detection optical signal transmissives obtain biochemical project testing result.
Embodiment 4
With reference to Fig. 3-1, Fig. 3-2 and Fig. 3-3, difference lies in the present embodiment with embodiment 1 for the analyzer of the present embodiment First transmitted light source L1, the second transmitted light source L2 and the 3rd transmitted light source L3 set multiple wavelength, by converting the first optical filter F1, the second optical filter F2 and the 3rd optical filter F3 obtain the transmitted light of different wave length, are detected for different biochemical projects.Described The wavelength of one optical filter F1, the second optical filter F2 and the 3rd optical filter F3 are different.
Embodiment 5
With reference to Fig. 3-1, Fig. 3-2 and Fig. 3-3, difference lies in the present embodiment with embodiment 1 for the analyzer of the present embodiment First scattering light source L4, the second scattering light source L5 and the 3rd scattering light source L6 set multiple wavelength, by converting the first optical filter F1, the second optical filter F2 and the 3rd optical filter F3 obtain the scattering light of different wave length, are detected for different biochemical projects.
Embodiment 6
The present embodiment detects the CRP and HbAle of 20 different samples using existing biochemical instruments from analyzer of the present invention Albumen result carries out correlation comparison, statistics such as table 1.
The different samples of table 1 are respectively with existing biochemical instruments compared with analyzer testing result of the present invention
Existing biochemical instruments are respectively adopted to be detected 20 different samples from analyzer of the present invention, and carry out correlation point Analysis, as shown in Figure 5 and Figure 6, two kinds of distinct methods testing result correlations:RCRP=0.9974 >=0.95, RHbA1C=0.9783 >=0.95, illustrate that the testing result correlation of existing biochemical instruments and analyzer of the present invention is good.

Claims (10)

1. a kind of blood cell and analysis of biochemical instrument, which is characterized in that including shift module, the first hemolytic agent addition mould Block, the second hemolytic agent add module, dilution add module, cleaning agent add module, cleaning module, mixing module, control mould Block, the first detection cup, the second detection cup and the 3rd detection cup;
The shift module is for shifting biochemical reagents and sample, including biochemical reagents position, sample position, suction needle, the first liquid Draw-out device, connecting line and mobile device;The mobile device is for driving suction needle in sample position, biochemical reagents position, the It is moved between one detection cup, the second detection cup and the 3rd detection cup;
The first hemolytic agent add module includes the first hemolytic agent position and second liquid draw-out device, for the first detection cup The first hemolytic agent of middle addition;
The second hemolytic agent add module includes the second hemolytic agent position and the 5th liquid extracting device, for the second detection cup The second hemolytic agent of middle addition;
The dilution add module includes a dilution liquid level and the 3rd liquid extracting device, for the first detection cup, the Dilution is injected in two detection cups, the 3rd detection cup, suction needle and suction needle washer;
The cleaning agent add module includes a cleaning agent position and the 4th liquid extracting device, for the first detection cup and the Cleaning agent is added in two detection cups;
The cleaning module includes suction needle washer, connecting line, waste liquid discharge pipe and waste drains pump, the suction needle cleaning Device is for cleaning suction needle outer wall, after the waste liquid discharge pipe is for discharging in detection cup waste liquid and the cleaning of suction needle washer The waste liquid of generation, the waste drains pump provide power for waste liquid discharge;
The mixing module is by first, second, and third detection cup bottom air-blowing, to the aqueous agitation mixing in detection cup;
Be respectively arranged on the wall of cup of first detection cup, the second detection cup and the 3rd detection cup the first grain count detection device, Second grain count detection device and the 3rd grain count detection device, the first grain count detection device and the second grain count Detection device is used to carry out karyocyte detection to liquid in cup, and the 3rd grain count detection device is for small to red blood cell and blood The quantity and volume of plate are detected;Transmitted light inspection is provided in one of detection cup of first detection cup and the second detection cup Device is surveyed, is detected for hemoglobin, at least one detection cup is provided with biochemistry detection in the first detection cup and the second detection cup Device, for adding in progress biochemical project detection after biochemical reagents;
The control module is controlling shift module, dilution add module, the first hemolytic agent add module, the second hemolytic agent Add module, cleaning agent add module, cleaning module, mixing module, the first detection cup, the second detection cup and the 3rd detection cup work Make, and perform detection Data Analysis Services, display, printing, output testing result and and external communication.
2. a kind of blood cell and analysis of biochemical instrument, which is characterized in that including shift module, the first hemolytic agent addition mould Block, the second hemolytic agent add module, the 3rd hemolytic agent add module, dilution add module, cleaning agent add module, cleaning mould Block, mixing module, control module, the first detection cup, the second detection cup, the 3rd detection cup and the 4th detection cup;
The shift module is for shifting biochemical reagents and sample, including biochemical reagents position, sample position, suction needle, the first liquid Draw-out device, connecting line and mobile device;The mobile device is for driving suction needle in sample position, biochemical reagents position, the It is moved between one detection cup, the second detection cup, the 3rd detection cup and the 4th detection cup;
The first hemolytic agent add module includes the first hemolytic agent position and second liquid draw-out device, for the first detection cup The first hemolytic agent of middle addition;
The second hemolytic agent add module includes the second hemolytic agent position and the 5th liquid extracting device, for the second detection cup The second hemolytic agent of middle addition;
The 3rd hemolytic agent add module includes the 3rd hemolytic agent position and the 6th liquid extracting device, for the 4th detection cup The 3rd hemolytic agent of middle addition;
The dilution add module includes a dilution liquid level and the 3rd liquid extracting device, for the first detection cup, the Dilution is injected in two detection cups, the 3rd detection cup, the 4th detection cup, suction needle and suction needle washer;
The cleaning agent add module includes a cleaning agent position and the 4th liquid extracting device, for the first detection cup, the Cleaning agent is added in two detection cups and the 4th detection cup;
The cleaning module includes suction needle washer, connecting line, waste liquid discharge pipe and waste drains pump, the suction needle cleaning Device is for cleaning suction needle outer wall, after the waste liquid discharge pipe is for discharging in detection cup waste liquid and the cleaning of suction needle washer The waste liquid of generation, the waste drains pump provide power for waste liquid discharge;
The mixing module is by the bottom air-blowing of first, second, third and fourth detection cup, to the aqueous agitation in detection cup Mixing;
First detection cup, the second detection cup, the 3rd detection cup and the 4th detection cup wall of cup on be respectively arranged with and be provided with first Grain count detection device, the second grain count detection device, the 3rd grain count detection device and the 4th grain count detection Device, the first grain count detection device, the second grain count detection device and the 4th grain count detection device are used for cup Middle liquid carries out karyocyte detection, the 3rd grain count detection device be used for red blood cell and hematoblastic quantity and volume into Row detection;Transmitted light detection dress is provided in one of detection cup of first detection cup, the second detection cup and the 4th detection cup It puts, is detected for hemoglobin, at least one detection cup is provided with life in the first detection cup, the second detection cup and the 4th detection cup Change detection device, for adding in progress biochemical project detection after biochemical reagents;
The control module is controlling shift module, dilution add module, the first hemolytic agent add module, the second hemolytic agent Add module, the 3rd hemolytic agent add module, cleaning agent add module, cleaning module, mixing module, the first detection cup, second Detection cup, the 3rd detection cup and the work of the 4th detection cup, and perform detection Data Analysis Services, display, printing, output detection knot Fruit and and external communication.
3. blood cell according to claim 2 and analysis of biochemical instrument, which is characterized in that on the first detection cup wall of cup Transmission optical detection device and the first biochemical detection device are provided with, the second biochemistry detection dress is provided on the second detection cup wall of cup It puts, the 3rd biochemical detection device is provided on the 4th detection cup wall of cup.
4. blood cell and analysis of biochemical instrument according to claim 1,2 or 3, which is characterized in that the biochemical inspection Surveying device includes one or both of transmission optical detection device and scattering optical detection device.
5. blood cell according to claim 1 or 2 and analysis of biochemical instrument, which is characterized in that analyzer further includes For cleaning the washer of suction needle outer wall.
6. blood cell according to claim 4 and analysis of biochemical instrument, which is characterized in that the scattering light detection dress It is multi-wavelength detection device to put and transmit optical detection device.
7. blood cell according to claim 1 or 2 and analysis of biochemical instrument, which is characterized in that analyzer further includes One Washing cup, for being cleaned to suction needle inside and outside.
A kind of 8. analysis method based on blood cell described in claim 3 and analysis of biochemical instrument, which is characterized in that the party Method comprises the following steps:
Step 1 quantitatively draws whole blood sample by suction needle from specimen cup, is quantitatively transferred to the first detection cup, the second detection In cup and the 4th detection cup, dilution add module is separately added into the first detection cup, the second detection cup and the 4th detection cup Quantitative dilution, and pass through the first detection cup of mixing module mixing, the second detection cup and the 4th detection cup;It is clear by suction needle Device is washed to clean suction needle outer wall;
Step 2 draws the blood after quantitative dilution, mixing by suction needle from the first, second, the 4th any one cup of detection cup Sample is transferred to the 3rd detection cup, is mixed with the dilution in cup, by mixing module to liquid blending in the 3rd detection cup, the 3rd Grain counting and detecting device carries out red blood cell and platelets analysis to blood sample after mixing in the 3rd detection cup;Pass through suction needle washer Suction needle outer wall is cleaned;
Step 3 adds in the first quantitative hemolytic agent by the first hemolytic agent add module and through mixing mould into the first detection cup Block is to liquid blending in the first detection cup, and the first grain count detection device and transmission optical detection device are respectively to the first detection cup Karyocyte and hemoglobin after mixing in blood sample are detected;
Step 4 adds in the second hemolytic agent, the second grain count detection by the second hemolytic agent adding set into the second detection cup Device is detected karyocyte;
Step 5 adds in the 3rd hemolytic agent, the 4th grain count detection by the 3rd hemolytic agent adding set into the 4th detection cup Device is detected karyocyte;
Suction needle after step 6, cleaning is moved to biochemical reagents position, draws the first quantitative biochemical reagents and is transferred to first Detection cup, liquid in the first detection cup of mixing again, by the first biochemical detection device to adding in the dilute of mixing after biochemical reagents It releases sample to be detected, obtains the testing result of corresponding biochemical project;
Suction needle after step 7, cleaning is moved to the second biochemical reagents position again, draws second quantitative of biochemical reagents and adds to the Two detection cups perform second of biochemical project by the second biochemical detection device and detect;Suction needle after cleaning quantitatively draws Three kinds of biochemical reagents add in the 4th detection cup, and performing the third biochemical project by the 3rd biochemical detection device detects.
9. the analysis method of blood cell according to claim 8 and analysis of biochemical instrument, which is characterized in that the life Changing detection device includes one or both of transmission optical detection device and scattering optical detection device.
10. the analysis method of blood cell according to claim 8 and analysis of biochemical instrument, which is characterized in that instrument Biochemistry detection result is modified automatically during detection, modified computing formulae is as follows:
Wherein modifying factor a is for correcting error caused by other influence factors, in the range of 0.3-4.0.
CN201610681443.0A 2016-08-17 2016-08-17 Blood cell and analysis of biochemical instrument and method Active CN106124751B (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
CN201610681443.0A CN106124751B (en) 2016-08-17 2016-08-17 Blood cell and analysis of biochemical instrument and method
PCT/CN2017/070576 WO2018032720A1 (en) 2016-08-17 2017-01-08 Blood cell and biochemical content analyzer and method

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN201610681443.0A CN106124751B (en) 2016-08-17 2016-08-17 Blood cell and analysis of biochemical instrument and method

Publications (2)

Publication Number Publication Date
CN106124751A CN106124751A (en) 2016-11-16
CN106124751B true CN106124751B (en) 2018-05-18

Family

ID=57279359

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201610681443.0A Active CN106124751B (en) 2016-08-17 2016-08-17 Blood cell and analysis of biochemical instrument and method

Country Status (2)

Country Link
CN (1) CN106124751B (en)
WO (1) WO2018032720A1 (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106370584A (en) * 2016-08-17 2017-02-01 江苏英诺华医疗技术有限公司 Blood corpuscle detection and biochemical detection instrument and detection method thereof
CN106124751B (en) * 2016-08-17 2018-05-18 江苏英诺华医疗技术有限公司 Blood cell and analysis of biochemical instrument and method
WO2019127959A1 (en) * 2017-12-26 2019-07-04 江苏英诺华医疗技术有限公司 Rapid detection system and method involving biochemical detection, enzyme immunoassay and chemiluminescence detection
WO2019127958A1 (en) * 2017-12-26 2019-07-04 江苏英诺华医疗技术有限公司 Medical rapid biochemical detection system and detection method

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101169450A (en) * 2006-10-27 2008-04-30 深圳迈瑞生物医疗电子股份有限公司 Full-automatic biochemical analysis method and device
US20100105074A1 (en) * 2008-10-27 2010-04-29 Nodality, Inc. A Delaware Corporation High throughput flow cytometry system and method
CN103543256A (en) * 2012-07-12 2014-01-29 三星电子株式会社 Inspection unit and fluid analysis cartridge
CN103792376A (en) * 2012-10-30 2014-05-14 希森美康株式会社 Sample analyzer
CN104122404A (en) * 2014-08-01 2014-10-29 江苏英诺华医疗技术有限公司 Novel rapid multi-parameter platelet functional analyzer and detection method thereof
WO2015054695A2 (en) * 2013-10-11 2015-04-16 Immunetics, Inc. Led assay reader with touchscreen control and barcode sample id
CN104833813A (en) * 2015-05-12 2015-08-12 江苏英诺华医疗技术有限公司 Analyzer with blood routine and biochemical detection functions

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0905514B1 (en) * 1997-09-27 2003-11-26 Horiba, Ltd. Blood cell count/immunoassay apparatus using whole blood
CN103336130B (en) * 2013-06-21 2016-03-16 嘉善加斯戴克医疗器械有限公司 A kind of whole blood immunity analytical equipment and use the blood analyser of this device
CN105334333B (en) * 2014-07-01 2019-06-18 深圳迈瑞生物医疗电子股份有限公司 A kind of whole blood measuring instrument and automatic sampling apparatus being easily changed latex reagent
CN105699380A (en) * 2016-03-23 2016-06-22 深圳市帝迈生物技术有限公司 Analysis equipment and method for simultaneously measuring CRP (C-Reactive Protein) and blood routine
CN106124751B (en) * 2016-08-17 2018-05-18 江苏英诺华医疗技术有限公司 Blood cell and analysis of biochemical instrument and method

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101169450A (en) * 2006-10-27 2008-04-30 深圳迈瑞生物医疗电子股份有限公司 Full-automatic biochemical analysis method and device
US20100105074A1 (en) * 2008-10-27 2010-04-29 Nodality, Inc. A Delaware Corporation High throughput flow cytometry system and method
CN103543256A (en) * 2012-07-12 2014-01-29 三星电子株式会社 Inspection unit and fluid analysis cartridge
CN103792376A (en) * 2012-10-30 2014-05-14 希森美康株式会社 Sample analyzer
WO2015054695A2 (en) * 2013-10-11 2015-04-16 Immunetics, Inc. Led assay reader with touchscreen control and barcode sample id
CN104122404A (en) * 2014-08-01 2014-10-29 江苏英诺华医疗技术有限公司 Novel rapid multi-parameter platelet functional analyzer and detection method thereof
CN104833813A (en) * 2015-05-12 2015-08-12 江苏英诺华医疗技术有限公司 Analyzer with blood routine and biochemical detection functions

Also Published As

Publication number Publication date
CN106124751A (en) 2016-11-16
WO2018032720A1 (en) 2018-02-22

Similar Documents

Publication Publication Date Title
CN106124751B (en) Blood cell and analysis of biochemical instrument and method
CN104833813B (en) It is a kind of while the analyser with blood routine and biochemistry detection function
US9767343B1 (en) Automated microscopic cell analysis
CN105051535B (en) System and method for determining chemical state
CN105699635A (en) Simple and reliable hemocyte five-class analysis method, system and device
US20120214224A1 (en) Flow based clinical analysis
EP0905514A1 (en) Blood cell count/immunoassay apparatus using whole blood
CN106370584A (en) Blood corpuscle detection and biochemical detection instrument and detection method thereof
CN107533047A (en) Urinalysis system, filming apparatus, cell filming apparatus, urinalysis method, managing device and information processing method
CN108732135A (en) A kind of blood cell and analysis of protein device
CN105699380A (en) Analysis equipment and method for simultaneously measuring CRP (C-Reactive Protein) and blood routine
JP2019528459A (en) Automated microscopic blood cell analysis
CN102998474A (en) Apparatus for aspirating and dispensing liquids in automated analyzer
CN104122404A (en) Novel rapid multi-parameter platelet functional analyzer and detection method thereof
US20210039093A1 (en) Automated microscopic cell analysis
US3876374A (en) Method and apparatus for automated quantitative fluid analysis
CN206020435U (en) Hemocyte and bio-chemical detector
JP5789635B2 (en) Whole blood blood cell immunoassay device
CN205538976U (en) Simple reliable five categorised analytical equipment of blood cell
CN102600918B (en) Microfluidic chip for blood analysis and method for using microfluidic chip
CN206161493U (en) Blood cell and biochemical composition analyzer
US4002269A (en) Liquid proportioning system in a liquid sample analyzer
Langford et al. Performance evaluation of the Sysmex XT-2000i automated hematology analyzer
CN106405131A (en) Cell and protein combined analysis device and combined analysis method
CN206648928U (en) A kind of multi-parameter blood analyser

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
GR01 Patent grant
GR01 Patent grant