CN106117653A - Medicinal synthesized polyisoprene gasket - Google Patents

Medicinal synthesized polyisoprene gasket Download PDF

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Publication number
CN106117653A
CN106117653A CN 201610492727 CN201610492727A CN106117653A CN 106117653 A CN106117653 A CN 106117653A CN 201610492727 CN201610492727 CN 201610492727 CN 201610492727 A CN201610492727 A CN 201610492727A CN 106117653 A CN106117653 A CN 106117653A
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parts
medicinal
gasket
polyisoprene
synthesized
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CN 201610492727
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Chinese (zh)
Inventor
龙庚求
王伟
刘鹏
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应城市恒天药业包装有限公司
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    • CCHEMISTRY; METALLURGY
    • C08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08LCOMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L9/00Compositions of homopolymers or copolymers of conjugated diene hydrocarbons

Abstract

The invention relates to a medicinal gasket, and particularly relates to a medicinal synthesized polyisoprene gasket, which is prepared by mixing the following components in parts by weight: 100 parts of polyisoprene rubber, 0.01-0.02 part of carbon black, 1-3 parts of a crosslinking agent, 3-5 parts of zinc oxide or organic zinc, 1-3 parts of stearic acid, 1-3 parts of accelerant, 20-30 parts of filler and 1-3 parts of a softening agent. The medicinal synthesized polyisoprene gasket can meet the requirement for using and processing a isoprene gasket and the requirement for the compatibility of a liquid medicine contacted with the gasket after sealing. The medicinal synthesized polyisoprene does not need chemical extraction, and has product cleanliness and good medicinal liquid compatibility.

Description

一种药用合成聚异戊二烯垫片 A pharmaceutical synthetic polyisoprene spacer

技术领域 FIELD

[0001]本发明涉及一种药用垫片,具体地说是一种药用合成聚异戊二烯垫片。 [0001] The present invention relates to a pharmaceutical gasket, in particular a pharmaceutical synthetic polyisoprene spacer.

背景技术 Background technique

[0002]目前市场上广泛使用的药用合成聚异戊二烯垫片大都需要经过化学抽提,且化学抽提之后仍然有某些指标不能达标,并且化学抽提存在二次污染的风险,抽提之后排放的酸碱污染环境,还有化学抽提也增加了一定的生产成本。 [0002] Currently medicinal synthetic polyisoprene pads on the market need to go through most of the widely used chemical extraction, and after chemical extraction still have some indicators can not be compliance, and chemical extraction there is a risk of secondary pollution, after the discharge of acid-base extraction pollute the environment, as well as certain chemical extraction also increased production costs.

发明内容 SUMMARY

[0003]本发明内容就是针对目前聚异戊二烯橡胶垫片需要抽提、化学指标不合格的问题,提供一种免化学抽提、超洁净异戊二烯橡胶垫片的配方。 [0003] The present invention addresses the current problems polyisoprene rubber gasket requires extraction, chemical indicators of failure, there is provided a no chemical extraction, ultra-clean formulation isoprene rubber gasket. 它既能满足异戊二烯垫片的使用要求和加工要求,又能够满足密封后对所接触的液体药物配伍性的要求。 It can meet the requirements and processing requirements isoprene gasket, and the sealing can meet the requirements of compatibility of the liquid drug in contact. 本发明最大的创新点在于所提供的异戊二烯垫片不需经过化学抽提,并且产品洁净度较高,与药液相容性较好。 The present invention is greatest innovation is isoprene spacer provided without chemically extracted, and higher product purity, preferably with chemical compatibility.

[0004]本发明的技术方案是这样实现的:它由下述原料按照重量份数混合而成:100份聚异戊二烯橡胶、0.01〜0.02重量份炭黑,I〜3重量份交联剂,3〜5重量份氧化锌或有机锌,I〜3重量份硬脂酸,I〜3重量份促进剂,20〜30重量份填充剂,I〜3重量份软化剂。 [0004] aspect of the present invention is implemented as follows: it is mixed according to the following raw materials in parts by weight from: 100 parts of polyisoprene rubber, 0.01~0.02 parts by weight of carbon black, parts by weight of a crosslinking I~3 agent, 3 to 5 parts by weight of zinc oxide or organic zinc, I~3 parts by weight of stearic acid, I~3 parts by weight accelerator, 20 to 30 parts by weight of a filler, I~3 parts by weight of a softener. 所述的交联剂为酚醛树脂类交联剂。 The crosslinking agent is a phenolic resin crosslinking agent. 所述的聚异戊二烯橡胶的数均分子量为40万到70万到,门尼粘度ML 1+4(100°C)50 到90。 The number average molecular weight of the polyisoprene rubber of 400,000 to 700,000, a Mooney viscosity ML 1 + 4 (100 ° C) 50 to 90

[0005]填料一般选用是由陶土、滑石粉、白炭黑、碳酸钙等组成;交联剂一般选择酚醛树脂或硫磺等;活性剂一般选择金属氧化物和(或)硬脂酸、着色剂一般选择钛白粉与碳黑。 [0005] The filler is generally used in clay, talc, silica, calcium carbonate, etc; crosslinking agent is generally a phenolic resin or sulfur selection; active agent generally selected metal oxide and (or) stearate, colorant titanium dioxide and carbon black is generally selected.

[0006]在本专利中使用的聚异戊二烯橡胶的材料包括是,那些具有数均分子量为40万到70万到,最好是50万;门尼粘度ML 1+4( 100C)50到90,最好是60到80, [0006] Materials polyisoprene rubber used in this patent include, those having a number average molecular weight of 400,000 to 700,000, preferably 500,000; Mooney viscosity ML 1 + 4 (100C) 50 to 90, preferably 60 to 80,

[0007]为了完成如上所述的聚异戊二烯橡胶垫片配方,各个材料在密炼机混合,在110Γ至IJ150°C,最好在120°C到140°C进行混合,以模压成型或者注射方式成型。 [0007] To complete the formulation polyisoprene rubber gasket as described above, each of the mixed materials in an internal mixer, in 110Γ to IJ150 ° C, preferably 120 ° C for mixing to 140 ° C, to molding or by injection molding.

[0008]本发明既能满足异戊二烯垫片的使用要求和加工要求,又能够满足密封后对所接触的液体药物配伍性的要求。 [0008] The present invention meets the requirements and processing requirements of isoprene gasket, but also to meet the requirements for compatibility after sealing the liquid drug in contact. 不需经过化学抽提,并且产品洁净度较高,与药液相容性较好。 Eliminate the need for chemical extraction, and higher product cleanliness, good compatibility with the liquid.

具体实施方式 detailed description

[0009]以下结合实施例对本发明作进一步描述 [0009] The following embodiments in conjunction with the present invention will be further described

[0010] 实施例一 [0010] Example a

[0011 ]本发明由下述原料按照重量份数混合而成:聚异戊二烯橡胶100,炭黑0.01,交联剂2,氧化锌或有机锌3,硬脂酸I,促进剂1.5,填充剂20(由陶土和碳酸钙组成),软化剂2.8。 [0011] The present invention is by mixing the following raw materials in parts by weight is made according to: polyisoprene rubber 100 Carbon black 0.01, crosslinking agent 2, 3 zinc oxide or organic zinc, stearic I, accelerators 1.5, 20 filler (calcium carbonate and a clay), softener 2.8. 所述的聚异戊二烯橡胶的数均分子量为40万到70万到,门尼粘度ML 1+4(100°C)50到90。 The number average molecular weight of the polyisoprene rubber of 400,000 to 700,000, a Mooney viscosity ML 1 + 4 (100 ° C) 50 to 90 制备方法是将上述各个材料通过密炼机共混,在11 (TC到150°C,最好在120 0C到140 °C进行混合,以模压成型或者注射方式成型。 The method of preparation is blending the above respective material through the mixer, at 11 (TC to 150 ° C, preferably at 120 0C were mixed to 140 ° C, in order to press molding or injection molding manner.

[0012]实施例二 [0012] Second Embodiment

[0013]本发明由下述原料按照重量份数混合而成:聚异戊二烯橡胶100,炭黑0.02,交联剂3,氧化锌或有机锌4,硬脂酸3,促进剂2,填充剂30(由陶土和碳酸钙组成),软化剂2.5。 [0013] The present invention is by mixing the following raw materials in parts by weight is made according to: polyisoprene rubber 100 Carbon black 0.02, crosslinking agent 3, zinc oxide or organic zinc 4, 3 stearate, accelerators 2, 30 filler (calcium carbonate and a clay), softener 2.5. 所述的聚异戊二烯橡胶的数均分子量为40万到70万到,门尼粘度ML 1+4(100°C)50到90。 The number average molecular weight of the polyisoprene rubber of 400,000 to 700,000, a Mooney viscosity ML 1 + 4 (100 ° C) 50 to 90 制备方法是将上述各个材料通过密炼机共混,在110°C到150°C,最好在120°C到140V进行混合,以模压成型或者注射方式成型。 The method of preparation is blending the above respective material through the mixer, at 110 ° C to 150 ° C, preferably to 140V were mixed at 120 ° C, in order to press molding or injection molding manner.

[0014] 实施例三 [0014] Example three

[0015]本发明由下述原料按照重量份数混合而成:聚异戊二烯橡胶100,炭黑0.01,交联剂2.3,氧化锌或有机锌3,硬脂酸3,促进剂1.5,填充剂30 (由陶土和碳酸钙组成),软化剂3。 [0015] The present invention according to the following raw materials by mixing together by weight: 100 polyisoprene rubber, carbon black, 0.01, 2.3 crosslinking agent, zinc oxide or organic zinc 3, 3 stearate, accelerators 1.5, 30 filler (calcium carbonate and a clay), softener 3. 所述的聚异戊二烯橡胶的数均分子量为40万到70万到,门尼粘度ML 1+4(100°C)50到90。 The number average molecular weight of the polyisoprene rubber of 400,000 to 700,000, a Mooney viscosity ML 1 + 4 (100 ° C) 50 to 90 制备方法是将上述各个材料通过密炼机共混,在11 (TC到150°C,最好在120 0C到140 °C进行混合,以模压成型或者注射方式成型。 The method of preparation is blending the above respective material through the mixer, at 11 (TC to 150 ° C, preferably at 120 0C were mixed to 140 ° C, in order to press molding or injection molding manner.

[0016]实施例四 [0016] Fourth Embodiment

[0017]本发明由下述原料按照重量份数混合而成:聚异戊二烯橡胶100,炭黑0.01,交联剂2.5,氧化锌或有机锌3,硬脂酸I,促进剂1.5,填充剂20 (由陶土和白炭黑组成),软化剂2.5。 [0017] The present invention according to the following raw materials by mixing together by weight: 100 polyisoprene rubber, carbon black, 0.01, 2.5 crosslinking agent, zinc oxide or organic zinc 3, stearate I, accelerators 1.5, 20 filler (clay and the white carbon black), softening agent 2.5. 所述的聚异戊二烯橡胶的数均分子量为40万到70万到,门尼粘度ML 1+4(100°C)50到90 ο制备方法是将上述各个材料通过密炼机共混,在110 °C到150 °C,最好在120 °C到140 °C进行混合,以模压成型或者注射方式成型。 The number average molecular weight of the polyisoprene rubber of 400,000 to 700,000, a Mooney viscosity ML 1 + 4 (100 ° C) 50 to 90 ο each of the foregoing methods of preparation are blended material through the mixer at 110 ° C to 150 ° C, preferably to 120 ° C for 140 ° C were mixed, to molding or by injection molding.

Claims (3)

  1. 1.一种药用合成聚异戊二烯垫片,它由下述原料按照重量份数混合而成:100份聚异戊二烯橡胶、0.0I〜0.02重量份炭黑,I〜3重量份交联剂,3〜5重量份氧化锌或有机锌,I〜3重量份硬脂酸,I〜3重量份促进剂,20〜30重量份填充剂,I〜3重量份软化剂。 1. A pharmaceutical synthetic polyisoprene spacer, which in accordance with the following raw materials by mixing together by weight: 100 parts of polyisoprene rubber, 0.0I~0.02 parts by weight of carbon black, I~3 weight crosslinking agent, 3 to 5 parts by weight of zinc oxide or organic zinc, I~3 parts by weight of stearic acid, I~3 parts by weight accelerator, 20 to 30 parts by weight of a filler, I~3 parts by weight of a softener.
  2. 2.根据权利要求1所述的一种药用合成聚异戊二烯垫片,其特征在于:所述的交联剂为酚醛树脂类交联剂。 2. A pharmaceutical according to claim 1 spacer synthetic polyisoprene, characterized in that: said crosslinking agent is a phenolic resin crosslinking agent.
  3. 3.根据权利要求1所述的一种药用合成聚异戊二烯垫片,其特征在于:所述的聚异戊二烯橡胶的数均分子量为40万到70万到,门尼粘度ML 1+4(100°C)50到90。 A pharmaceutical according to claim 1, said spacer synthetic polyisoprene, characterized in that: said number-average molecular weight of the polyisoprene rubber is 400,000 to 700,000, a Mooney viscosity ML 1 + 4 (100 ° C) 50 to 90
CN 201610492727 2016-06-28 2016-06-28 Medicinal synthesized polyisoprene gasket CN106117653A (en)

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Publication number Priority date Publication date Assignee Title
US5861473A (en) * 1991-12-18 1999-01-19 Schering Corporation Method for cleaning elastomeric articles
CN102993493A (en) * 2012-08-22 2013-03-27 安徽中马橡塑制品有限公司 Medicinal synthetic polyisoprene gasket composition
CN104194084A (en) * 2014-09-02 2014-12-10 盛州医药包装材料科技(中国)有限公司 Frosting-free medicinal infusion rubber gasket
CN104744744A (en) * 2015-03-04 2015-07-01 安徽华峰医药橡胶有限公司 Polyisoprene gasket synthesized by medicinal film

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5861473A (en) * 1991-12-18 1999-01-19 Schering Corporation Method for cleaning elastomeric articles
CN102993493A (en) * 2012-08-22 2013-03-27 安徽中马橡塑制品有限公司 Medicinal synthetic polyisoprene gasket composition
CN104194084A (en) * 2014-09-02 2014-12-10 盛州医药包装材料科技(中国)有限公司 Frosting-free medicinal infusion rubber gasket
CN104744744A (en) * 2015-03-04 2015-07-01 安徽华峰医药橡胶有限公司 Polyisoprene gasket synthesized by medicinal film

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
张可喜等: "《材料合成与制备研究》", 30 April 2014 *
张玉龙等: "《橡胶品种与性能手册》", 31 January 2007 *

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