CN106109524A - A kind of Chinese medicine extraction compositions and preparation method thereof, Chinese medicine smokeless moxa roll and Chinese medicine massage oil - Google Patents

A kind of Chinese medicine extraction compositions and preparation method thereof, Chinese medicine smokeless moxa roll and Chinese medicine massage oil Download PDF

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CN106109524A
CN106109524A CN201610674967.7A CN201610674967A CN106109524A CN 106109524 A CN106109524 A CN 106109524A CN 201610674967 A CN201610674967 A CN 201610674967A CN 106109524 A CN106109524 A CN 106109524A
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chinese medicine
radix
cortex eucommiae
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陶然
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61HPHYSICAL THERAPY APPARATUS, e.g. DEVICES FOR LOCATING OR STIMULATING REFLEX POINTS IN THE BODY; ARTIFICIAL RESPIRATION; MASSAGE; BATHING DEVICES FOR SPECIAL THERAPEUTIC OR HYGIENIC PURPOSES OR SPECIFIC PARTS OF THE BODY
    • A61H39/00Devices for locating or stimulating specific reflex points of the body for physical therapy, e.g. acupuncture
    • A61H39/06Devices for heating or cooling such points within cell-life limits
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    • A61K47/44Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
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    • A61K2236/30Extraction of the material
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    • A61K2236/50Methods involving additional extraction steps
    • A61K2236/51Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/50Methods involving additional extraction steps
    • A61K2236/53Liquid-solid separation, e.g. centrifugation, sedimentation or crystallization

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Abstract

The invention provides a kind of Chinese medicine extraction compositions and preparation method thereof, Chinese medicine smokeless moxa roll and Chinese medicine massage oil, relate to Chinese medicine health-care technical field.Described Chinese medicine extraction compositions includes in Radix Notoginseng extract, Radix Astragali extract, Cortex Eucommiae extract or Radix Ginseng extract any one or the combination of at least two and Folium Artemisiae Argyi extract.This Chinese medicine extraction compositions can be applicable to, in all kinds of cosmetic health product and method, play effect of blood circulation promoting and blood stasis dispelling, dredging the meridian, building body and nourishing and health preserving.Utilize Chinese medicine smokeless moxa roll prepared by this Chinese medicine extraction compositions, on the basis of retaining original moxa roll effective ingredient, have Chinese medicine health-care effect concurrently.Chinese medicine massage oil pole prepared by this Chinese medicine extraction compositions is utilized easily to be absorbed by the body utilizations through skin, the effect of enhancing health care massage.

Description

A kind of Chinese medicine extraction compositions and preparation method thereof, Chinese medicine smokeless moxa roll and Chinese medicine are pressed Rub oil
Technical field
The present invention relates to Chinese medicine health-care technical field, in particular to a kind of Chinese medicine extraction compositions and preparation side thereof Method, Chinese medicine smokeless moxa roll and Chinese medicine massage oil.
Background technology
The traditional Chinese medical science through thousand of years clinical practice it was confirmed the traditional Chinese medical science either curing the disease, be all true in diseases prevention, or health preserving Dig effective and feasible.Moxa-moxibustion, as one of traditional Chinese medical science essential therapeutic arsenals, originates from ancient dynasties of China, the Chinese mugwort made with Folium Artemisiae Argyi The Ai heat that moxibustion material produces stimulates body surface point or specific part, is adjusted the physiology of human disorder by the activity of stimulating Qi of meridian Biochemical function, play promoting of the circulation of QI and removing the obstruction in the collaterals, supporting YANG to cure collaps-syndrome as emergency treatment, blood circulation promoting and blood stasis dispelling, draw out pus by applying a plaster to the affected part expel the heat-evil, effects such as beauty treatment of prolonging life, thus reach diseases prevention A kind of Therapeutic Method of purpose of curing the disease.
Traditional puncture can produce a large amount of smog when carrying out moxibustion, and these smog are unrelated with effect of moxa-moxibustion, but cause The pollution of indoor environment, reduces the experience of moxibustion, and health even causes certain harm.In view of this, smokelessly end Bar, smokeless moxibustion post, gradually by the most well-established, become tradition moxa roll succedaneum.The production process of smokeless moxa roll needs will end Leaf or batten high temperature carbonization, the most effective ingredient in Folium Artemisiae Argyi can lose in this course, and the moxa roll so obtained makes Used time only has heat effect, can not be fully achieved effect of traditional puncture.
Chinese herbal medicine, is approved with cognitive the most widely by practice for thousands of years.Know that natural resources of Chinese medicinal materials sum reaches The one over thousands of kind of WANLIANG, wherein, Radix Notoginseng, the Radix Astragali, the Cortex Eucommiae, Radix Ginseng are the most warm in nature and and have in effect of building body, nourishing Medical herbs.Principle active component in Radix Notoginseng, the Radix Astragali, the Cortex Eucommiae, Radix Ginseng is glucosides class material, but the hydrophilic not lipophilic of glucosides class material, Molecular weight is relatively big, there is the problem being difficult to absorbing transmission from skin, so being the most all so that principal mode for absorb is administered orally, It is difficult to be smeared or the external mode such as massage is absorbed into internal by external.
How the effective ingredient in Chinese herbal medicine is blended with moxa-moxibustion and other health-care methods, become the focus of exploitation.
In view of this, the special proposition present invention.
Summary of the invention
The first object of the present invention is to provide a kind of Chinese medicine extraction compositions, and this Chinese medicine extraction compositions can be applicable to respectively In class cosmetic health product and method, play effect of blood circulation promoting and blood stasis dispelling, dredging the meridian, building body and nourishing and health preserving.
The second object of the present invention is to provide a kind of Chinese medicine smokeless moxa roll, and this Chinese medicine smokeless moxa roll is retaining original moxa roll On the basis of effective ingredient, have Chinese medicine health-care effect concurrently.
The third object of the present invention is to provide a kind of Chinese medicine massage oil, and this Chinese medicine massage oil pole easily passes through skin by human body Absorb, strengthen the effect of health care massage.
In order to realize the above-mentioned purpose of the present invention, spy by the following technical solutions:
A kind of Chinese medicine extraction compositions, including following raw material: Radix Notoginseng extract, Radix Astragali extract, Cortex Eucommiae extract or people Any one or the compositions of at least two and Folium Artemisiae Argyi extract in conopsea extraction.
Folium Artemisiae Argyi extract containing abundant volatile oil and Flavonoid substances, have antibacterial, antiviral, eliminate the phlegm, relieving cough and asthma, anti- The multiple efficacies such as allergy, anticoagulation, complement activation and calmness.
Radix Notoginseng extract is mainly composed of Radix Notoginseng total arasaponins, and life-time service can improve microcirculation, promoting blood circulation to remove obstruction in the collateral, softening blood Pipe, lowering blood pressure and blood fat, treatment hepatic fibrosis etc..
Radix Astragali extract is mainly composed of Radix Astragali saponin and astragalus polysaccharides, its have enhancing human body immunity function, protect the liver, profit Urine, defying age, blood pressure lowering and wide antibacterial action.
Cortex Eucommiae extract is mainly composed of glucosides class and phenylpropanoids, can rubbish in purged body, to strengthen human body thin Born of the same parents' substance metabolism, prevent that muscle skeleton is aging, balanced human's blood pressure, decomposer inner cholesterol, reduce body fat, recover blood vessel Elasticity, diuresis heat clearing away, broad-spectrum antiseptic, stimulating central nervous system and the effect of raising leukocyte.
Radix Ginseng extract is that Hydrolysis kinetics forms from the root of Radix Ginseng, stem and leaf, and it is rich in 18 kinds of ginseng saponinses, Ginsenoside can substantially suppress lipid peroxide in brain regulating liver-QI to be formed, and reduces the content of lipofuscin in cerebral cortex regulating liver-QI, with Time also can increase superoxide dismutase and catalase content in blood, there is antioxidation.Additionally, Radix Ginseng soap Partial monosomy saponin such as rg3, rg2, rb1, rb2, rd, rc, re, rg1 etc. in glycosides can reduce interior free yl to some extent Content.Ginsenoside can delay neurocyte old and feeble and reduce memory impairment, and has stable membrane structure and increase protein conjunction One-tenth effect, can improve memory ability.
By Radix Notoginseng extract, Radix Astragali extract, Cortex Eucommiae extract or Radix Ginseng extract are matched with Folium Artemisiae Argyi extract Use, play the synergism of various crude drug, can arbitrarily add the Chinese medicine extraction compositions of preparation to all kinds of aesthetic health care In product, play effect of blood circulation promoting and blood stasis dispelling, dredging the meridian, building body and nourishing and health preserving.
Preferably, above-mentioned Chinese medicine extraction compositions, including following raw material: Folium Artemisiae Argyi extract, Radix Notoginseng extract, astragalus extraction Thing, Cortex Eucommiae extract and Radix Ginseng extract.
Preferably, in above-mentioned Chinese medicine extraction compositions, Folium Artemisiae Argyi extract be 50-80 weight portion, Radix Notoginseng extract be 5-10 Weight portion, Radix Astragali extract be 5-20 weight portion, Cortex Eucommiae extract be 10-25 weight portion and Radix Ginseng extract 2-6 weight portion.
In the present invention, the typical but non-limiting content of Folium Artemisiae Argyi extract for example: 50 weight portions, 55 weight portions, 60 weights Amount part, 65 weight portions, 70 weight portions, 75 weight portions or 80 weight portions.
In the present invention, the typical but non-limiting content of Radix Notoginseng extract for example: 5 weight portions, 6 weight portions, 7 weight Part, 8 weight portions, 9 weight portions or 10 weight portions.
In the present invention, the typical but non-limiting content of Radix Astragali extract for example: 5 weight portions, 6 weight portions, 7 weight Part, 8 weight portions, 9 weight portions, 10 weight portions, 11 weight portions, 12 weight portions, 13 weight portions, 14 weight portions, 15 weight portions, 16 weights Amount part, 17 weight portions, 18 weight portions, 19 weight portions or 20 weight portions.
In the present invention, the typical but non-limiting content of Cortex Eucommiae extract for example: 10 weight portions, 11 weight portions, 12 weights Amount part, 13 weight portions, 14 weight portions, 15 weight portions, 16 weight portions, 17 weight portions, 18 weight portions, 19 weight portions, 20 weight portions, 21 weight portions, 22 weight portions, 23 weight portions, 24 weight portions or 25 weight portions.
In the present invention, the typical but non-limiting content of Radix Ginseng extract for example: 2 weight portions, 3 weight portions, 4 weight Part, 5 weight portions or 16 weight portions.
Preferably, in above-mentioned Chinese medicine extraction compositions, Folium Artemisiae Argyi extract be 65 weight portions, Radix Notoginseng extract be 8 weight portions, Radix Astragali extract is that 13 weight portions, Cortex Eucommiae extract are 17 weight portions and Radix Ginseng extract is 4 weight portions.
By further optimizing the proportion relation of each raw material, the synergism of each raw material can be improved further, Strengthen using effect.
Preferably, above-mentioned Folium Artemisiae Argyi extract is by water-ethanol heating and refluxing extraction, concentrates ethanol and obtain big portion after filtration It is divided into the effective ingredient of volatile oil and Flavonoid substances.
Preferably, extracted by Radix Notoginseng, the Radix Astragali, the Cortex Eucommiae or Radix Ginseng the most respectively and obtain glucosides, then by acid-hydrolysis method hydrolysis sugar Glycosidic bond, obtains hydrolyzate aglycon after removing glycosyl, obtain after drying Radix Notoginseng extract, Radix Astragali extract, Cortex Eucommiae extract or Radix Ginseng extract.
Preferably, the most respectively Radix Notoginseng, the Radix Astragali, the Cortex Eucommiae or Radix Ginseng are pulverized, extract glucosides class material with ultrasonic extraction, Again by acid-hydrolysis method hydrolyzing glucosidic bonds, after removing glycosyl, obtain hydrolyzate aglycon, extract through extracting, obtain after drying Radix Notoginseng Thing, Radix Astragali extract, Cortex Eucommiae extract or Radix Ginseng extract.
In the present invention, the glycosyl in the effective ingredient glucosides class material of Radix Notoginseng, the Radix Astragali, the Cortex Eucommiae and Radix Ginseng is removed, obtains The aglycon corresponding with effective ingredient.Aglycon has good lipotropy, it is possible to be dissolved in lipid component, its transdermal capability It is greatly improved compared with polyglycoside molecule.In moxa-moxibustion and massage, while skin heart and body surface point are upset, aglycon energy Enough enter internal through skin, play synergism with moxa-moxibustion and massage.In use play blood circulation promoting and blood stasis dispelling, dredging warp Effect of network, building body and nourishing and health preserving.
Preferably, in Chinese medicine extraction compositions, the content of glucosides is less than the 5% of gross weight.
The reduction of Glycosides Contents imply that its hydrolysis is relatively abundant, available more aglycon material, thus strengthens absorption effect Really, the loss of effective ingredient is reduced.
The preparation method of above-mentioned Chinese medicine extraction compositions, comprises the following steps:
By any one or the group of at least two in Radix Notoginseng extract, Radix Astragali extract, Cortex Eucommiae extract or Radix Ginseng extract Close and mix with Folium Artemisiae Argyi extract, obtain Chinese medicine extraction compositions.
Preferably, the process preparing Folium Artemisiae Argyi extract includes: be placed in solvent by Folium Artemisiae Argyi, is heated to reflux, is filtrated to get and carries Taking liquid, extracting solution is dried to obtain Folium Artemisiae Argyi extract.
Preferably, preparing in the step of Folium Artemisiae Argyi extract, described solvent is water-ethanol solvent.
Preferably, the mass ratio of described water-ethanol is 1:1.
Preferably, described in be heated to reflux temperature and be 55-65 DEG C, the time is 1.5-2.5h.
In the present invention, be heated to reflux typical but non-limiting temperature for example: 55 DEG C, 56 DEG C, 57 DEG C, 58 DEG C, 59 DEG C, 60 DEG C, 61 DEG C, 62 DEG C, 63 DEG C, 64 DEG C or 65 DEG C.
In the present invention, be heated to reflux the typical but non-limiting time for example: 1.5h, 1.6h, 1.7h, 1.8h, 1.9h, 2h, 2.1h, 2.2h, 2.3h, 2.4h or 2.5h.
Preferably, described in be heated to reflux temperature be 60 DEG C, the time is 2h.
Preferably, the process preparing Radix Notoginseng extract, Radix Astragali extract, Cortex Eucommiae extract or Radix Ginseng extract includes: first The most respectively Radix Notoginseng, the Radix Astragali, the Cortex Eucommiae or Radix Ginseng are pulverized, extract glucosides class material with ultrasonic extraction, then hydrolyzed by acid-hydrolysis method Glycosidic bond, obtains hydrolyzate aglycon after removing glycosyl, through extracting, obtaining Radix Notoginseng extract, Radix Astragali extract, the Cortex Eucommiae after drying Extract or Radix Ginseng extract.
Preferably, a length of 2-4h when hydrolyzing in acid hydrolysis.
In the present invention, the typical but non-limiting duration of hydrolytic process for example: 2h, 2.5h, 3h, 3.5h or 4h.
Preferably, ultrasonic extraction extraction time is 35-50min.
In the present invention, the typical but non-limiting extraction time of ultrasonic extraction for example: 35min, 36min, 37min、38min、39min、40min、41min、42min、43min、44min、45min、46min、47min、48min、49min Or 50min.
Preferably, extraction process is adopted and is extracted with ethyl acetate.
Preferably, in described Chinese medicine extraction compositions, the content of glucosides is less than the 5% of gross weight.
Radix Notoginseng extract, Radix Astragali extract, Cortex Eucommiae extract or Radix Ginseng prepared by the method utilizing the present invention to provide extract Thing, utilizes Hydrolyze method to be removed by the glycosyl on the polyglycoside molecule in Radix Notoginseng, the Radix Astragali, the Cortex Eucommiae and Radix Ginseng, has obtained and effective ingredient Corresponding aglycon.Aglycon has good lipotropy, it is possible to be dissolved in lipid component, its transdermal capability and polyglycoside molecule phase Ratio is greatly improved.In moxa-moxibustion and massage, while skin heart and body surface point are upset, aglycon can enter through skin Enter internal, play synergism with moxa-moxibustion and massage.The Chinese medicine extraction compositions prepared by the method contains substantial amounts of aglycon Effective constituents, the effective ingredient of different crude drug sources plays synergism, in use plays blood circulation promoting and blood stasis dispelling, dredging warp Effect of network, building body and nourishing and health preserving.
A kind of Chinese medicine smokeless moxa roll, described Chinese medicine smokeless moxa roll is prepared by following steps: by Folium Artemisiae Argyi parch, grinding It is placed in the solvent containing above-mentioned Chinese medicine extraction compositions infiltration with molding, obtains Chinese medicine smokeless moxa roll after drying.
Above-mentioned Chinese medicine extraction compositions is dissolved and is infiltrated smokeless moxa roll in a solvent by the present invention, utilizes the nothing after parch carbonization The character adsorbing Chinese medicine of cigarette moxa roll porous surface extracts the effective ingredient of compositions, thus obtains Chinese medicine smokeless moxa roll.Use Time light Chinese medicine smokeless moxa roll after, the effective ingredient volatilized in Chinese medicine extraction compositions by breathe and transdermal effect enter body In, play treatment and health effect.The Chinese medicine smokeless moxa roll that the present invention provides solves popular smokeless moxa roll and damages in process of production The problem losing effective ingredient, the advantage possessing traditional moxa roll, more it is attached with the merit of the Chinese herbal medicine of Radix Notoginseng, the Radix Astragali, the Cortex Eucommiae and Radix Ginseng Effect.
Preferably, in the solvent of infiltration, the content of Chinese medicine extraction compositions is 10-40 weight %.
Preferably, in the solvent of infiltration, the content of Chinese medicine extraction compositions is 25 weight %.
Preferably, infiltrating time is 15-60min.
Preferably, above-mentioned solvent is ethanol.
A kind of Chinese medicine massage oil, including following raw material: base oil 60-85 weight portion, Chinese medicine extraction compositions 15-40 weight Part.
Above-mentioned Chinese medicine extraction compositions is added to base oil is prepared Chinese medicine massage oil, Chinese medicine extraction during use, can be made The effective ingredient of compositions enters in body through skin, plays a role in health care.When moxa-moxibustion with the use of, can improve moxibustion While treating body-sensing, more effectively play the health-care effect of moxibustion.
In the present invention, the typical but non-limiting content of base oil for example: 60 weight portions, 65 weight portions, 70 weight portions, 75 weight portions, 80 weight portions or 85 weight portions.
In the present invention, Chinese medicine extraction compositions oil typical but non-limiting content for example: 15 weight portions, 20 weight Part, 25 weight portions, 30 weight portions, 35 weight portions or 40 weight portions.
Preferably, above-mentioned Chinese medicine massage oil includes following raw material: base oil 65-80 weight portion, Chinese medicine extraction compositions 20- 35 weight portions.
Preferably, any one or at least two during described base oil includes olive oil, Oleum Vitis viniferae or Semen Tritici aestivi germ oil Combination.
Compared with the prior art, there is advantages that
By Radix Notoginseng extract, Radix Astragali extract, Cortex Eucommiae extract or Radix Ginseng extract are matched with Folium Artemisiae Argyi extract Use, play the synergism of various crude drug, can arbitrarily add the Chinese medicine extraction compositions of preparation to all kinds of aesthetic health care In product, play effect of blood circulation promoting and blood stasis dispelling, dredging the meridian, building body and nourishing and health preserving.
Radix Notoginseng extract, Radix Astragali extract, Cortex Eucommiae extract or Radix Ginseng prepared by the method utilizing the present invention to provide extract Thing, utilizes Hydrolyze method to be removed by the glycosyl on the polyglycoside molecule in Radix Notoginseng, the Radix Astragali, the Cortex Eucommiae and Radix Ginseng, has obtained and effective ingredient Corresponding aglycon.Aglycon has good lipotropy, it is possible to be dissolved in lipid component, its transdermal capability and polyglycoside molecule phase Ratio is greatly improved.In moxa-moxibustion and massage, while skin heart and body surface point are upset, aglycon can enter through skin Enter internal, play synergism with moxa-moxibustion and massage.The Chinese medicine extraction compositions prepared by the method contains substantial amounts of aglycon Effective constituents, the effective ingredient of different crude drug sources plays synergism, in use plays blood circulation promoting and blood stasis dispelling, dredging warp Effect of network, building body and nourishing and health preserving.
Above-mentioned Chinese medicine extraction compositions is dissolved and is infiltrated smokeless moxa roll in a solvent by the present invention, utilizes the nothing after parch carbonization The character adsorbing Chinese medicine of cigarette moxa roll porous surface extracts the effective ingredient of compositions, thus obtains Chinese medicine smokeless moxa roll.Use Time light Chinese medicine smokeless moxa roll after, the effective ingredient volatilized in Chinese medicine extraction compositions by breathe and transdermal effect enter body In, play treatment and health effect.The Chinese medicine smokeless moxa roll that the present invention provides solves popular smokeless moxa roll and damages in process of production The problem losing effective ingredient, the advantage possessing traditional moxa roll, more it is attached with Radix Notoginseng, the Radix Astragali, the Cortex Eucommiae and effect of Radix Ginseng Chinese herbal medicine.
Above-mentioned Chinese medicine extraction compositions is added to base oil is prepared Chinese medicine massage oil, Chinese medicine extraction during use, can be made The effective ingredient of compositions enters in body through skin, plays a role in health care.When moxa-moxibustion with the use of, can improve moxibustion While treating body-sensing, more effectively play the health-care effect of moxibustion.
Detailed description of the invention
Below in conjunction with embodiment, embodiment of the present invention are described in detail, but those skilled in the art will Understanding, the following example is merely to illustrate the present invention, and is not construed as limiting the scope of the present invention.In embodiment unreceipted specifically Condition person, the condition advised according to normal condition or manufacturer is carried out.Agents useful for same or instrument unreceipted production firm person, be Can be by the commercially available conventional products bought and obtain.
Below in conjunction with embodiment 1-29 and comparative example 1-8 to Chinese medicine extraction compositions of invention and preparation method thereof, in Medicine smokeless moxa roll and Chinese medicine massage oil are further described in detail.
The Chinese medicine extraction compositions that embodiment 1-17 provides is prepared by the following method and obtains, and difference is each raw material Content different:
1) Folium Artemisiae Argyi extract is prepared: be placed in by Folium Artemisiae Argyi in the water-ethanol solvent that mass ratio is 1:1, heat back at 55-65 DEG C Flowing 1.5-2.5h, be filtrated to get extracting solution, extracting solution is dried to obtain Folium Artemisiae Argyi extract;
2) prepare Radix Notoginseng extract, Radix Astragali extract, Cortex Eucommiae extract or Radix Ginseng extract: by Radix Notoginseng, the Radix Astragali, the Cortex Eucommiae or After Radix Ginseng is pulverized, use ultrasonic extraction to extract 35-50min and obtain the component containing glucosides, go with acid-hydrolysis method hydrolysis 2-4h The hydrolyzate aglycon obtained after falling the glycosyl of glucosides, is dried after being extracted with ethyl acetate out aglycon, obtains Radix Notoginseng extract, Huang Stilbene extract, Cortex Eucommiae extract or Radix Ginseng extract;
3) Chinese medicine extraction compositions is prepared: by Radix Notoginseng extract, Radix Astragali extract, Cortex Eucommiae extract or the people of above-mentioned preparation In conopsea extraction, the combination of any one or at least two mixes with Folium Artemisiae Argyi extract, obtains Chinese medicine extraction compositions.
Raw material contained by the Chinese medicine extraction compositions that embodiment 1~12 provides is as shown in table 1, embodiment 13~17 and comparative example Raw material contained by the Chinese medicine extraction compositions that 1-2 provides is as shown in table 2.
Raw material composition contained by table 1 embodiment 1~12
Table 2 embodiment 13~17 and comparative example 1-2 contained by raw material composition
Embodiment 18~23 uses different preparation method to prepare Chinese medicine extraction compositions.
Embodiment 18
1) it takes thing to prepare Folium Artemisiae Argyi: smashed to pieces by 20g Folium Artemisiae Argyi, water-ethanol ratio be 1:1 as Extraction solvent, 60 DEG C of heating Reflux, extract, 2h, filters, and extracting solution is dried after concentrating, and obtains 1g Folium Artemisiae Argyi extract;
2) Radix Notoginseng extract, Radix Astragali extract, Cortex Eucommiae extract or Radix Ginseng extract are prepared: cleaned by 20g Radix Notoginseng and dry After, adding pure water with the ratio of solid-to-liquid ratio 1:30,45 DEG C of supersound extraction 40min obtain glucosides class material, add in extracting solution Appropriate hydrochloric acid makes hydrochloric acid total concentration be 4%, and hydrolysis 3h at a temperature of 90 DEG C obtains aglycon composition, uses acetic acid after cooling Ethyl ester extracts, and obtains aglycon 0.8g after drying standby;The method preparing Radix Astragali extract, Cortex Eucommiae extract and Radix Ginseng extract is same Radix Notoginseng extract;
3) Chinese medicine extraction compositions is prepared: weigh Folium Artemisiae Argyi extract 65mg, Radix Notoginseng extract 8mg, Radix Astragali extract 13mg, Cortex Eucommiae extract 18mg, Radix Ginseng extract 4mg, obtain Chinese medicine extraction compositions after mixing.
Embodiment 19
1) it takes thing to prepare Folium Artemisiae Argyi: smashed to pieces by 20g Folium Artemisiae Argyi, water-ethanol ratio be 1:1 as Extraction solvent, 65 DEG C of heating Reflux, extract, 1.5h, filters, and extracting solution is dried after concentrating, and obtains 0.9g Folium Artemisiae Argyi extract;
2) Radix Notoginseng extract, Radix Astragali extract, Cortex Eucommiae extract or Radix Ginseng extract are prepared: cleaned by 20g Radix Notoginseng and dry After, adding pure water with the ratio of solid-to-liquid ratio 1:30,45 DEG C of supersound extraction 50min obtain glucosides class material, add in extracting solution Appropriate hydrochloric acid makes hydrochloric acid total concentration be 4%, and hydrolysis 2h at a temperature of 90 DEG C obtains aglycon composition, uses acetic acid after cooling Ethyl ester extracts, and obtains aglycon 0.6g after drying standby;The method preparing Radix Astragali extract, Cortex Eucommiae extract and Radix Ginseng extract is same Radix Notoginseng extract;
3) Chinese medicine extraction compositions is prepared: weigh Folium Artemisiae Argyi extract 65mg, Radix Notoginseng extract 8mg, Radix Astragali extract 13mg, Cortex Eucommiae extract 18mg, Radix Ginseng extract 4mg, obtain Chinese medicine extraction compositions after mixing.
Embodiment 20
1) it takes thing to prepare Folium Artemisiae Argyi: smashed to pieces by 20g Folium Artemisiae Argyi, water-ethanol ratio be 1:1 as Extraction solvent, 55 DEG C of heating Reflux, extract, 2.5h, filters, and extracting solution is dried after concentrating, and obtains 0.9g Folium Artemisiae Argyi extract;
2) Radix Notoginseng extract, Radix Astragali extract, Cortex Eucommiae extract or Radix Ginseng extract are prepared: cleaned by 20g Radix Notoginseng and dry After, adding pure water with the ratio of solid-to-liquid ratio 1:30,45 DEG C of supersound extraction 35min obtain glucosides class material, add in extracting solution Appropriate hydrochloric acid makes hydrochloric acid total concentration be 4%, and hydrolysis 4h at a temperature of 90 DEG C obtains aglycon composition, uses acetic acid after cooling Ethyl ester extracts, and obtains aglycon 0.7g after drying standby;The method preparing Radix Astragali extract, Cortex Eucommiae extract and Radix Ginseng extract is same Radix Notoginseng extract;
3) Chinese medicine extraction compositions is prepared: weigh Folium Artemisiae Argyi extract 65mg, Radix Notoginseng extract 8mg, Radix Astragali extract 13mg, Cortex Eucommiae extract 18mg, Radix Ginseng extract 4mg, obtain Chinese medicine extraction compositions after mixing.
Embodiment 21
1) it takes thing to prepare Folium Artemisiae Argyi: after being smashed to pieces by 100g Folium Artemisiae Argyi, water-ethanol ratio be 1:1 as Extraction solvent, 60 DEG C add Circumfluence distillation 2h, filters, and extracting solution is dried after concentrating, and obtains 4.8g Folium Artemisiae Argyi extract;
2) Radix Notoginseng extract, Radix Astragali extract, Cortex Eucommiae extract or Radix Ginseng extract are prepared: cleaned by 50g Radix Notoginseng and dry After, adding pure water with the ratio of solid-to-liquid ratio 1:15,45 DEG C of supersound extraction 40min, to obtain glucosides class material, add in extracting solution Entering appropriate hydrochloric acid makes hydrochloric acid total concentration be 4%, hydrolysis 3h at a temperature of 90 DEG C, and the aglycon obtaining glucosides class material becomes Point, it is extracted with ethyl acetate after cooling, obtains aglycon 2g after drying standby.Prepare Radix Astragali extract, Cortex Eucommiae extract and Radix Ginseng The same Radix Notoginseng extract of method of extract;
3) Chinese medicine extraction compositions is prepared: weigh Folium Artemisiae Argyi extract 65mg, Radix Notoginseng extract 8mg, Radix Astragali extract 13mg, Cortex Eucommiae extract 18mg, Radix Ginseng extract 4mg, obtain Chinese medicine extraction compositions after mixing.
Embodiment 22
1) it takes thing to prepare Folium Artemisiae Argyi: after being smashed to pieces by 100g Folium Artemisiae Argyi, water-ethanol ratio be 1:1 as Extraction solvent, 65 DEG C add Circumfluence distillation 1.5h, filters, and extracting solution is dried after concentrating, and obtains 4.5g Folium Artemisiae Argyi extract;
2) Radix Notoginseng extract, Radix Astragali extract, Cortex Eucommiae extract or Radix Ginseng extract are prepared: cleaned by 50g Radix Notoginseng and dry After, adding pure water with the ratio of solid-to-liquid ratio 1:15,45 DEG C of supersound extraction 50min, to obtain glucosides class material, add in extracting solution Entering appropriate hydrochloric acid makes hydrochloric acid total concentration be 4%, hydrolysis 2h at a temperature of 90 DEG C, and the aglycon obtaining glucosides class material becomes Point, it is extracted with ethyl acetate after cooling, obtains aglycon 1.9g after drying standby.Prepare Radix Astragali extract, Cortex Eucommiae extract and people The same Radix Notoginseng extract of method of conopsea extraction.
3) Chinese medicine extraction compositions is prepared: weigh Folium Artemisiae Argyi extract 65mg, Radix Notoginseng extract 8mg, Radix Astragali extract 13mg, Cortex Eucommiae extract 18mg, Radix Ginseng extract 4mg, obtain Chinese medicine extraction compositions after mixing.
Embodiment 23
1) it takes thing to prepare Folium Artemisiae Argyi: after being smashed to pieces by 100g Folium Artemisiae Argyi, water-ethanol ratio be 1:1 as Extraction solvent, 55 DEG C add Circumfluence distillation 2.5h, filters, and extracting solution is dried after concentrating, and obtains 4.6g Folium Artemisiae Argyi extract;
2) Radix Notoginseng extract, Radix Astragali extract, Cortex Eucommiae extract or Radix Ginseng extract are prepared: cleaned by 50g Radix Notoginseng and dry After, adding pure water with the ratio of solid-to-liquid ratio 1:15,45 DEG C of supersound extraction 35min, to obtain glucosides class material, add in extracting solution Entering appropriate hydrochloric acid makes hydrochloric acid total concentration be 4%, hydrolysis 4h at a temperature of 90 DEG C, and the aglycon obtaining glucosides class material becomes Point, it is extracted with ethyl acetate after cooling, obtains aglycon 1.8g after drying standby.Prepare Radix Astragali extract, Cortex Eucommiae extract and people The same Radix Notoginseng extract of method of conopsea extraction;
3) Chinese medicine extraction compositions is prepared: weigh Folium Artemisiae Argyi extract 65mg, Radix Notoginseng extract 8mg, Radix Astragali extract 13mg, Cortex Eucommiae extract 18mg, Radix Ginseng extract 4mg, obtain Chinese medicine extraction compositions after mixing.
Embodiment 24-26 uses different preparation methoies to prepare with the Chinese medicine smokeless moxa roll that comparative example 3-5 provides.
Embodiment 24
Take clean Folium Artemisiae Argyi to dry, put parch carbonization in pot, dry in the air cool after grind to form smalls and make Chinese mugwort charcoal, Chinese mugwort charcoal loads moxa roll machine Extruded, drying, obtains smokeless moxa roll.Configuration is containing the second of the Chinese medicine extraction compositions of preparation in 25 weight % embodiments 21 Alcoholic solution, infiltrates smokeless moxa roll wherein, takes out after 30min, In Shade dry, obtains Chinese medicine smokeless moxa roll.
Embodiment 25
Take clean Folium Artemisiae Argyi to dry, put parch carbonization in pot, dry in the air cool after grind to form smalls and make Chinese mugwort charcoal, Chinese mugwort charcoal loads moxa roll machine Extruded, drying, obtains smokeless moxa roll.Configuration is containing the second of the Chinese medicine extraction compositions of preparation in 40 weight % embodiments 21 Alcoholic solution, infiltrates smokeless moxa roll wherein, takes out after 15min, In Shade dry, obtains Chinese medicine smokeless moxa roll.
Embodiment 26
Take clean Folium Artemisiae Argyi to dry, put parch carbonization in pot, dry in the air cool after grind to form smalls and make Chinese mugwort charcoal, Chinese mugwort charcoal loads moxa roll machine Extruded, drying, obtains smokeless moxa roll.Configuration is containing the second of the Chinese medicine extraction compositions of preparation in 10 weight % embodiments 21 Alcoholic solution, infiltrates smokeless moxa roll wherein, takes out after 60min, In Shade dry, obtains Chinese medicine smokeless moxa roll.
Comparative example 3
Popular smokeless moxa roll
Comparative example 4
Take clean Folium Artemisiae Argyi to dry, put parch carbonization in pot, dry in the air cool after grind to form smalls and make Chinese mugwort charcoal, Chinese mugwort charcoal loads moxa roll machine Extruded, drying, obtains smokeless moxa roll.Configuration is containing the ethanol of the Chinese medicine extraction compositions of preparation in 5 weight % comparative examples 1 Solution, infiltrates smokeless moxa roll wherein, takes out after 10min, In Shade dry, obtains Chinese medicine smokeless moxa roll.
Comparative example 5
Take clean Folium Artemisiae Argyi to dry, put parch carbonization in pot, dry in the air cool after grind to form smalls and make Chinese mugwort charcoal, Chinese mugwort charcoal loads moxa roll machine Extruded, drying, obtains smokeless moxa roll.Configuration is containing the ethanol of the Chinese medicine extraction compositions of preparation in 8 weight % comparative examples 2 Solution, infiltrates smokeless moxa roll wherein, takes out after 10min, In Shade dry, obtains Chinese medicine smokeless moxa roll.
The moxa roll provided by embodiment 24-26 has the insomnia forgetfulness of same or like symptom, digestive disease, neck to 80 examples The patient of vertebra pain, treating swelling and pain by traumatic injury, obesity, nephritis, interior-heat and lassitude carries out moxibustion treatment, wherein, the trouble of every kind of disease Person's quantity is 10.The moxa roll provided by comparative example 3-5 has the insomnia forgetfulness of same or like symptom, digestion disease to 80 examples The patient of disease, cervical vertebra ache, treating swelling and pain by traumatic injury, obesity, nephritis, interior-heat and lassitude carries out moxibustion treatment, wherein, every kind of disease Patient populations be 10.After lighting can Moxibustion on Acupoints, local Chinese mugwort is smoked and whole body Chinese mugwort is smoked.From skin 10~30mm during moxibustion, extremely Skin warm is rubescent.Every patient's moxa-moxibustion 3-4 time weekly, each 20min, continue one month, the effectiveness of moxa-moxibustion is entered Row statistics, result is as shown in table 3.
Table 3 moxa-moxibustion statistical effect table
By above treatment information it can be seen that the Chinese medicine prepared of Chinese medicine extraction compositions provided by the present invention smokelessly ends Bar, has obvious therapeutic effect to multiple symptom.
A kind of Chinese medicine massage oil, including following raw material: base oil 60-85 weight portion, Chinese medicine extraction compositions 15-40 weight Part.Wherein, base oil mainly by one or more in olive oil, Oleum Vitis viniferae or Semen Tritici aestivi germ oil with arbitrary proportion compatibility structure Become.
The Chinese medicine massage oil that embodiment 27-29 and comparative example 6-8 provide is adopted as different raw materials and prepares.
Embodiment 27
Weigh Chinese medicine extraction compositions 25mg of preparation in embodiment 21, join in the olive oil of 75mg, stirring and dissolving, It is configured to the Chinese medicine massage oil containing 25% Chinese medicine extraction compositions, static stable rear subpackage.
Embodiment 28
Weigh Chinese medicine extraction compositions 15mg of preparation in embodiment 21, join Semen Tritici aestivi germ oil and the Semen Vitis viniferae of 85mg In the mixed base oil of oil, wherein Semen Tritici aestivi germ oil is 1:1 with the ratio of Oleum Vitis viniferae, and stirring and dissolving is configured to containing 20% The Chinese medicine massage oil of Chinese medicine extraction compositions.
Embodiment 29
Weigh Chinese medicine extraction compositions 40mg of preparation in embodiment 21, join the olive oil of 60mg, Semen Tritici aestivi germ oil With in the mixed base oil of Oleum Vitis viniferae, wherein olive oil, Semen Tritici aestivi germ oil are 1:1:1 with the ratio of Oleum Vitis viniferae, stir molten Solve, be configured to the Chinese medicine massage oil containing 40% Chinese medicine extraction compositions.
Comparative example 6
Weigh Chinese medicine extraction compositions 15mg of preparation in comparative example 1, join Semen Tritici aestivi germ oil and the Semen Vitis viniferae of 85mg In the mixed base oil of oil, wherein Semen Tritici aestivi germ oil is 1:1 with the ratio of Oleum Vitis viniferae, and stirring and dissolving is configured to containing 20% The Chinese medicine massage oil of Chinese medicine extraction compositions.
Comparative example 7
Weigh Chinese medicine extraction compositions 15mg of preparation in comparative example 2, join Semen Tritici aestivi germ oil and the Semen Vitis viniferae of 85mg In the mixed base oil of oil, wherein Semen Tritici aestivi germ oil is 1:1 with the ratio of Oleum Vitis viniferae, and stirring and dissolving is configured to containing 20% The Chinese medicine massage oil of Chinese medicine extraction compositions.
Comparative example 8
Commercially available common massage oil.
The Chinese medicine massage oil provided by embodiment 27-29, coordinates moxibustion treatment to use.80 examples there is same or like symptom The patient of insomnia forgetfulness, digestive disease, cervical vertebra ache, treating swelling and pain by traumatic injury, obesity, nephritis, interior-heat and lassitude carry out moxa-moxibustion Treatment, wherein, the patient populations of every kind of disease is 10.The massage oil provided by comparative example 6-8, coordinates moxibustion treatment to use. 80 examples are had the insomnia forgetfulness of same or like symptom, digestive disease, cervical vertebra ache, treating swelling and pain by traumatic injury, obesity, nephritis, interior-heat and The patient of lassitude carries out moxibustion treatment, and wherein, the patient populations of every kind of disease is 10.This is used when moxibustion treatment The acupuncture points such as bright Chinese medicine massage oil massage Shenque, the gate of vitality, middle wrist, Guan Yuan, tsu san li, it is possible to play blood circulation promoting and blood stasis dispelling, nourishing the liver and kidney, Reduce blood pressure blood fat, improves the effects such as immunocompetence.Every patient's moxa-moxibustion 3-4 time weekly, each 20min, continue one month, right The effectiveness of moxa-moxibustion is added up, and result is as shown in table 4.
Table 4 moxa-moxibustions+massage effect statistical table
By above treatment information it can be seen that the Chinese medicine prepared of Chinese medicine extraction compositions provided by the present invention smokelessly ends Bar coordinates Chinese medicine massage oil, can further improve the therapeutic effect of various symptom.
Although illustrate and describing the present invention with specific embodiment, but it will be appreciated that without departing substantially from the present invention's May be made that in the case of spirit and scope many other change and amendment.It is, therefore, intended that in the following claims Including all such changes and modifications belonged in the scope of the invention.

Claims (10)

1. a Chinese medicine extraction compositions, it is characterised in that include following raw material: Radix Notoginseng extract, Radix Astragali extract, the Cortex Eucommiae carry Take in thing or Radix Ginseng extract any one or the combination of at least two and Folium Artemisiae Argyi extract.
Chinese medicine extraction compositions the most according to claim 1, it is characterised in that include following raw material: Folium Artemisiae Argyi extract, three Seven extracts, Radix Astragali extract, Cortex Eucommiae extract and Radix Ginseng extract.
Chinese medicine extraction compositions the most according to claim 1 and 2, it is characterised in that Folium Artemisiae Argyi extract is 50-80 weight Part, Radix Notoginseng extract be 5-10 weight portion, Radix Astragali extract be 5-20 weight portion, Cortex Eucommiae extract be 10-25 weight portion and people Conopsea extraction 2-6 weight portion;
Preferably, Folium Artemisiae Argyi extract be 65 weight portions, Radix Notoginseng extract be 8 weight portions, Radix Astragali extract be 13 weight portions, the Cortex Eucommiae Extract is 17 weight portions and Radix Ginseng extract 4 weight portion;
Preferably, extracted by Radix Notoginseng, the Radix Astragali, the Cortex Eucommiae or Radix Ginseng the most respectively and obtain glucosides, then by acid-hydrolysis method hydrolyzing glucosidic bonds, Obtain hydrolyzate aglycon after removing glycosyl, obtain Radix Notoginseng extract, Radix Astragali extract, Cortex Eucommiae extract or Radix Ginseng after drying and carry Take thing;
Preferably, the most respectively by Radix Notoginseng, the Radix Astragali, the Cortex Eucommiae or Radix Ginseng pulverize, with ultrasonic extraction extract glucosides class material, then by Acid-hydrolysis method hydrolyzing glucosidic bonds, obtains hydrolyzate aglycon after removing glycosyl, through extracting and obtaining Radix Notoginseng extract, Huang after drying Stilbene extract, Cortex Eucommiae extract or Radix Ginseng extract;
Preferably, in Chinese medicine extraction compositions, the content of glucosides is less than the 5% of gross weight.
4. the preparation method of the Chinese medicine extraction compositions as described in any one of claim 1-3, it is characterised in that include with Lower step:
By the combination of any one or at least two in Radix Notoginseng extract, Radix Astragali extract, Cortex Eucommiae extract or Radix Ginseng extract with Folium Artemisiae Argyi extract mixes, and obtains Chinese medicine extraction compositions.
The preparation method of Chinese medicine extraction compositions the most according to claim 4, it is characterised in that
The process preparing Folium Artemisiae Argyi extract includes: be placed in solvent by Folium Artemisiae Argyi, is heated to reflux, is filtrated to get extracting solution, extracting solution It is dried to obtain Folium Artemisiae Argyi extract;
Preferably, described solvent is water-ethanol solvent;
Preferably, the mass ratio of described water-ethanol is 1:1;
Preferably, described in be heated to reflux temperature and be 55-65 DEG C, the time is 1.5-2.5h;
Preferably, described in be heated to reflux temperature be 60 DEG C, the time is 2h;
Preferably, the process preparing Radix Notoginseng extract, Radix Astragali extract, Cortex Eucommiae extract or Radix Ginseng extract includes: first divide Radix Notoginseng, the Radix Astragali, the Cortex Eucommiae or Radix Ginseng are not pulverized, extract glucosides class material with ultrasonic extraction, then hydrolyzed glucosides by acid-hydrolysis method Key, obtains hydrolyzate aglycon after removing glycosyl, through extracting, obtain after drying Radix Notoginseng extract, Radix Astragali extract, Cortex Eucommiae extraction Thing or Radix Ginseng extract;
Preferably, a length of 2-4h when hydrolyzing in acid hydrolysis;
Preferably, ultrasonic extraction extraction time is 35-50min;
Preferably, extraction process is adopted and is extracted with ethyl acetate;
Preferably, in described Chinese medicine extraction compositions, the content of glucosides is less than the 5% of gross weight.
6. a Chinese medicine smokeless moxa roll, it is characterised in that described Chinese medicine smokeless moxa roll is prepared by following steps:
Folium Artemisiae Argyi parch, grinding and molding are placed on the solvent containing the Chinese medicine extraction compositions described in any one of claim 1-5 Middle infiltration, obtains Chinese medicine smokeless moxa roll after drying.
Chinese medicine smokeless moxa roll the most according to claim 6, it is characterised in that Chinese medicine extraction compositions in the solvent of infiltration Content be 10-40 weight %;
Preferably, in the solvent of infiltration, the content of Chinese medicine extraction compositions is 25 weight %;
Preferably, infiltrating time is 15-60min;
Preferably, described solvent is ethanol.
8. a Chinese medicine massage oil, it is characterised in that include following raw material: base oil 60-85 weight portion and claim 1-5 are appointed One described Chinese medicine extraction compositions 15-40 weight portion.
Chinese medicine massage the most according to claim 8 oil, it is characterised in that include following raw material: base oil 65-80 weight portion With the Chinese medicine extraction compositions 20-35 weight portion described in any one of claim 1-5.
Chinese medicine massage oil the most according to claim 8 or claim 9, it is characterised in that described base oil includes olive oil, Fructus Vitis viniferae Any one or the combination of at least two in seed oil or Semen Tritici aestivi germ oil.
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CN104958494A (en) * 2015-07-21 2015-10-07 青岛蓝盛洋医药生物科技有限责任公司 Application of medicinal composition in preparation of medicament for treating gynecological hemorrhage
CN104922543A (en) * 2015-07-21 2015-09-23 青岛蓝盛洋医药生物科技有限责任公司 Medicine composite for treating amenorrhea and preparation method thereof
CN104940509A (en) * 2015-07-27 2015-09-30 青岛蓝盛洋医药生物科技有限责任公司 Application of medicine composition in preparing medicine for treating gynecology hemorrhage syndrome
CN105288537A (en) * 2015-09-30 2016-02-03 叶宗耀 Pharmaceutical composition for treating female climacteric syndrome and preparing method thereof
CN205145113U (en) * 2015-11-18 2016-04-13 宿录贞 Moxa stick that moxa -moxibustion was used
CN105343149A (en) * 2015-12-02 2016-02-24 山东中医药大学 Application of eucommia ulmoides to preparation of medicinal moxa sticks
CN105727090A (en) * 2016-04-25 2016-07-06 秦朝东 Preparation method of Chinese medicine pills for treating uterine bleeding
CN105749063A (en) * 2016-04-25 2016-07-13 秦朝东 Chinese medicine instant granules for treating kidney deficiency uterine bleeding and preparation method thereof

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CN106923952A (en) * 2017-03-13 2017-07-07 江西如意宝医疗器材有限公司 A kind of Cortex Cunninghamiae Lanceolatae Medical fixation strap
CN106667859A (en) * 2017-03-23 2017-05-17 广州金缔雅生物科技有限公司 Healthcare chest-enlarging weight-losing molding multifunctional massage oil for external use and preparation method thereof
CN107184638A (en) * 2017-04-20 2017-09-22 周婕 A kind of Chinese medicine smokeless moxa roll and preparation method thereof
CN107569385A (en) * 2017-08-23 2018-01-12 安徽楚艾农业科技有限公司 A kind of moxa stick additive and preparation method thereof
CN107569407A (en) * 2017-08-30 2018-01-12 广州暨南生物医药研究开发基地有限公司 A kind of massage oil and its production and use
CN110859864A (en) * 2019-12-05 2020-03-06 江苏食品药品职业技术学院 Preparation process of folium artemisiae argyi extract and application of folium artemisiae argyi extract in preparation of acute kidney injury medicine
CN112156001A (en) * 2020-08-24 2021-01-01 江苏三才五妍医疗科技发展有限公司 Preparation method of smokeless moxa cone
CN112587564A (en) * 2021-01-06 2021-04-02 张沧良 Self-heating medicinal plaster

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Application publication date: 20161116