CN106075748A - Wobbling magnet diffusion proton beam is utilized to carry out the method and device of oncotherapy - Google Patents
Wobbling magnet diffusion proton beam is utilized to carry out the method and device of oncotherapy Download PDFInfo
- Publication number
- CN106075748A CN106075748A CN201610614055.0A CN201610614055A CN106075748A CN 106075748 A CN106075748 A CN 106075748A CN 201610614055 A CN201610614055 A CN 201610614055A CN 106075748 A CN106075748 A CN 106075748A
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- Prior art keywords
- proton beam
- proton
- wobbling
- carry out
- wobbling magnet
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
- A61N5/1042—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy with spatial modulation of the radiation beam within the treatment head
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
- A61N5/1042—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy with spatial modulation of the radiation beam within the treatment head
- A61N5/1043—Scanning the radiation beam, e.g. spot scanning or raster scanning
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
- A61N5/1042—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy with spatial modulation of the radiation beam within the treatment head
- A61N5/1045—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy with spatial modulation of the radiation beam within the treatment head using a multi-leaf collimator, e.g. for intensity modulated radiation therapy or IMRT
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
- A61N5/1077—Beam delivery systems
- A61N5/1081—Rotating beam systems with a specific mechanical construction, e.g. gantries
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
- A61N2005/1085—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy characterised by the type of particles applied to the patient
- A61N2005/1087—Ions; Protons
Abstract
The present invention relates to a kind of Therapeutic Method and device utilizing wobbling magnet diffusion proton beam to carry out tumor, first the method comprises the steps:, is converged by the proton beam (10) dissipated by concentrating element (1)；Secondly, the proton beam (10) after converging is scattered by wobbling magnet (3), makes it around proton center Periodic Rotating, forms a most uniformly line (11)；Then, after this uniform line (11) is passed through the collimator (9) of tumor leading portion, a homogeneous beam spot consistent with tumor shape (12) is obtained.Use Therapeutic Method and the device of the present invention; the visual field can be irradiated greatly, beam spot that the uniformity is high, this beam spot is consistent with patient's tumor region, thus protects the normal structure of patient to the full extent; the method greatly reduces the difficulty built with control, and moves insensitive to the position of tumor.
Description
Technical field
The invention belongs to field of medical technology, be specifically related to one and utilize wobbling magnet diffusion proton beam to carry out tumor
The method and device for the treatment of.
Background technology
Proton therapeutic mainly utilizes accelerator to produce the proton beam of certain energy, beam transfer is arrived by each electromagnetic component
Target area, bombards tumor cell, reaches the effect for the treatment of.Owing to proton energy loss in material presents sharp-pointed Bragg
Peak, therefore can farthest protect normal structure while killing cancerous tumor cell, and this makes proton therapeutic become current
One of the most state-of-the-art treating malignant tumor means.
The treatment head that traditional proton therapeutic appts uses has two kinds of basic modes: scatters and scans.Wherein, scattering method
It is to utilize proton to be subject to repeatedly low-angle elasticity Coulomb scattering when passing scatter plate, reaches the purpose of horizontal line extension, this dress
The shortcoming put is to be difficult to obtain the proton beam of big irradiation field and high evenness, and structure is complicated, causes rotary frame the most stupid
Weight；The mode of scanning is to install a pair sweeping magnet at treatment head, obtains dosage by the changes of magnetic field controlling sweeping magnet
Uniform irradiation field, the shortcoming of this device is that displacement own to tumor is sensitive, controls difficulty big.
Summary of the invention
For defect present in prior art, the present invention provides one to utilize wobbling magnet diffusion proton beam to carry out
The method and device of oncotherapy, the uniform line of available big irradiation field；Reduce the control difficulty of beam spot, will not be to normally
Tissue damage；Device is simple, builds with easy to control.
For reaching object above, the technical solution used in the present invention is: provide one to utilize wobbling magnet to spread matter
First the method for sub-Shu Jinhang oncotherapy, comprise the steps:, is converged by the proton beam dissipated by concentrating element
Poly-；Secondly, the proton beam after converging is scattered by wobbling magnet, makes it around proton center Periodic Rotating, shape
Become a most uniformly line；Then, homogeneous beam stream is adjusted by the collimator of tumor leading portion, by tumor region
Outer proton beam card falls；Finally, a homogeneous beam spot consistent with tumor shape is obtained.
Further, the proton beam after being converged by concentrating element, before entering wobbling magnet, by the first matter
Its cross section and stream are measured by force by sub-beam diagnostics device.
Further, the proton beam after being scanned by wobbling magnet, then pass sequentially through energy modulator and range position
After proton beam energy broadening and scope are adjusted by shifting device respectively, enter collimator.
Further, the proton beam after being adjusted by energy modulator and range shifter, then pass through multi-leaf optical grating respectively
Adjust beam spot shape on target with patient's compensator, the proton beam card outside tumor region is fallen and according to patient tumors
After the degree of depth and Adjusting Shape beam energy, enter collimator.
Further, it is additionally provided with between range shifter and multi-leaf optical grating for proton beam cross section and stream are surveyed by force
The second proton beam diagnostic equipment of amount.
The present invention also provides for a kind of utilizing wobbling magnet diffusion proton beam to carry out the device of oncotherapy, including for
The proton beam dissipated carries out the concentrating element converged, and the proton beam after converging scatters, makes it around in proton
The wobbling magnet of heart Periodic Rotating, formation one the most uniformly line, after processing wobbling magnet
Homogeneous beam flow to Row sum-equal matrix, the collimator fallen by the proton beam card outside tumor region.
Further, it is provided with between described concentrating element and wobbling magnet for carrying out cutting to the proton beam after converging
Face and the strong first proton beam diagnostic equipment measured of stream.
Further, it is sequentially provided with for the Energy Broadening to proton beam between described wobbling magnet and collimator
Energy modulator, for proton beam energy scope is adjusted range shifter, for adjust after proton beam
Cross section and stream measure by force the second proton beam diagnostic equipment, for adjusting beam spot shape on target, by tumor region
Multi-leaf optical grating that outer proton beam card falls, patient for the degree of depth according to patient tumors and Adjusting Shape beam energy compensate
Device.
The Advantageous Effects of the present invention is:
The Therapeutic Method of the present invention, utilizes the mechanical periodicity magnetic field being perpendicular to proton beam that wobbling magnet produces, should
Magnetic field size is constant, direction cyclically-varying, and proton beam, behind this magnetic field, will be around beam center Periodic Rotating, shape
Become the beam spot of a high evenness on a large scale, after this homogeneous beam spot is by the collimator before sufferer, finally give one and sick
The homogeneous beam spot that people's tumor region is consistent, thus protect the normal structure of patient；The method greatly reduces the difficulty of control, and
Movement to knub position is insensitive；The therapy equipment that the present invention provides, simple in construction, easy to control.
Accompanying drawing explanation
Fig. 1 is the structure chart that wobbling magnet of the present invention diffusion proton beam carries out therapeutic apparatus for treating tumor；
Fig. 2 be wobbling magnet of the present invention with collimator with the use of schematic diagram；
Fig. 3 is the fundamental diagram of wobbling magnet of the present invention.
In figure:
1-concentrating element 2-the first proton beam diagnostic equipment 3-wobbling magnet 4-energy modulator 5-range
Shifter 6-the second proton beam diagnostic equipment 7-multi-leaf optical grating 8-patient's compensator 9-collimator 10-proton beam
11-uniform line 12-homogeneous beam spot
Detailed description of the invention
Below in conjunction with the accompanying drawings, the detailed description of the invention of the present invention is described in further detail.
As shown in Figure 1, 2, it is that the wobbling magnet diffusion proton beam that utilizes that the present invention proposes carries out therapeutic apparatus for treating tumor,
This device includes concentrating element 1, the first proton beam diagnostic equipment 2, wobbling magnet 3, energy modulator 4, range successively
Shifter 5, the second proton beam diagnostic equipment 6, multi-leaf optical grating 7, patient's compensator 8, collimator 9, above-mentioned each parts are by bundle
Flow tube road is connected.Wherein, the first proton beam diagnostic equipment 2 and the second proton beam diagnostic equipment 6 are ionization chamber.Rotation is swept
Retouch Magnet 3 to be powered by a three phase mains.
The present invention is transferred to treat the proton beam 10 that head dissipates, and after line focus element 1 converges, is examined by proton beam
Disconnected device 2 measures by force diagnosis to its cross section and stream, flows to wobbling magnet 3, and this wobbling magnet 3 will produce
Being perpendicular to the magnetic field of the mechanical periodicity of proton beam, proton beam is under the effect of this wobbling magnet, it will in line
Heart Periodic Rotating, forms the most uniformly line 11 after wobbling magnet, and the uniform line 11 after expansion passes through energy
Amount manipulator 4 and range shifter 5 carry out Energy Broadening and modulation, diagnose its cross section by the second proton beam diagnostic equipment 6
Strong with stream, in order to adjust the proton beam degree of depth in focus, by patient's compensator 8 according to the degree of depth of patient tumors and shape
Adjust beam energy, prevent tumor rear portion normal structure impaired, multi-leaf optical grating 7 and the combination of collimator 9, can be by focus edge
Line card fall, finally obtain the homogeneous beam spot 12 consistent with focus shape, thus avoid the normal structure of patient to suffer damage.
As it is shown on figure 3, this wobbling magnet utilize be perpendicular to proton beam, size is constant, direction cyclically-varying
Magnetic field, make by the proton beam of this wobbling magnet by the periodically variable active force in direction, in the effect of this power
Under, proton beam will be around wobbling magnet center Periodic Rotating；Owing to proton beam itself is in Gauss distribution, therefore when
When proton beam is around wobbling magnet central rotation, the proton beam of marginal portion, by superposition, forms a center uniform
The beam spot of distribution.In figure: abscissa r/mm is the radius of turn of proton beam；Vertical coordinate Beam profile is proton beam
Rotation profile.
The present invention also provides for a kind of method utilizing wobbling magnet diffusion proton beam to carry out oncotherapy, including as follows
Step:
1) being converged by the proton beam 10 dissipated by concentrating element 1, the proton beam 10 after then converging leads to
Cross the first proton beam diagnostic equipment 2 to its carry out cross section and stream measure by force；
2) by by the proton beam 10 after measuring, entering wobbling magnet 3, wobbling magnet 3 utilizes it to produce
Size constant, the periodically variable Dipole magnet field in direction drives proton beam to rotate on target, obtain the highest uniformly
The uniform line 11 of degree；
3) the uniform line 11 obtained passes through energy modulator 4 and range shifter 5 respectively to its Energy Broadening and modulation；
4) measured after modulation, uniformly the cross section of line is strong with stream by the second proton beam diagnostic equipment 6 the most again；
5) by multi-leaf optical grating 7, adjust beam spot shape on target, the proton beam card outside tumor region is fallen；
6) by patient's compensator 8, according to the degree of depth and the Adjusting Shape beam energy of patient tumors, just tumor rear portion is being prevented
Often tissue damaged；
7) collimator 9 coordinates with multi-leaf optical grating 7, obtains the homogeneous beam spot 12 consistent with focus shape.
The method and device that the present invention utilizes wobbling magnet diffusion proton beam to carry out oncotherapy is not limited to above-mentioned
Detailed description of the invention, those skilled in the art draw other embodiment according to technical scheme, also belong to this
The technological innovation scope of invention.
Claims (8)
1. the method utilizing wobbling magnet diffusion proton beam to carry out oncotherapy, comprises the steps: first, to pass through
The proton beam (10) dissipated is converged by concentrating element (1)；Secondly, the proton beam (10) after converging is swept by rotation
Retouch Magnet (3) to scatter, make it around proton center Periodic Rotating, form a most uniformly line (11)；Then, will
Uniformly line (11) is adjusted by the collimator (9) of tumor leading portion, is fallen by the proton beam card outside tumor region；Finally,
Obtain a homogeneous beam spot consistent with tumor shape (12).
The method utilizing wobbling magnet diffusion proton beam to carry out oncotherapy the most as claimed in claim 1, is characterized in that:
Proton beam (10) after being converged by concentrating element (1), before entering wobbling magnet (3), by the first proton beam
It is carried out the stream diagnostic equipment (2) cross section and stream measures by force.
The method utilizing wobbling magnet diffusion proton beam to carry out oncotherapy the most as claimed in claim 2, is characterized in that:
Proton beam (10) after being scanned by wobbling magnet (3), then pass sequentially through energy modulator (4) and range shifter
(5), after respectively proton beam energy broadening and scope being adjusted, collimator (9) is entered.
The method utilizing wobbling magnet diffusion proton beam to carry out oncotherapy the most as claimed in claim 3, is characterized in that:
Proton beam (10) after being adjusted by energy modulator (4) and range shifter (5), more respectively by multi-leaf optical grating (7) and
Patient's compensator (8) adjusts beam spot shape on target, falls and the proton beam card outside tumor region according to patient tumors
After the degree of depth and Adjusting Shape beam energy, enter collimator (9).
The method utilizing wobbling magnet diffusion proton beam to carry out oncotherapy the most as claimed in claim 4, is characterized in that:
Be additionally provided with between range shifter (5) and multi-leaf optical grating (7) for proton beam cross section and stream measure by force second
The proton beam diagnostic equipment (6).
6. utilize wobbling magnet diffusion proton beam to carry out a device for oncotherapy, it is characterized in that: include for sending out
The proton beam (10) dissipated carries out the concentrating element (1) that converges, the proton beam (10) after converging scatters, make its around
The wobbling magnet (3) of proton center Periodic Rotating, formation one the most uniformly line (11), for scan process
After uniform line (11) collimator (9) that is adjusted and the proton beam card outside tumor region is fallen.
Utilize wobbling magnet diffusion proton beam to carry out the device of oncotherapy the most as claimed in claim 6, it is characterized in that:
It is provided with between described concentrating element (1) and wobbling magnet (3) for the proton beam after converging being carried out cross section and flowing strong
The first proton beam diagnostic equipment (2) measured.
Utilize wobbling magnet diffusion proton beam to carry out the device of oncotherapy the most as claimed in claim 7, it is characterized in that:
It is sequentially provided with the energy modulation for the Energy Broadening to proton beam between described wobbling magnet (3) and collimator (9)
Device (4), for the range shifter (5) that the energy range of proton beam is adjusted, for the proton beam after adjusting
Cross section and stream measure by force the second proton beam diagnostic equipment (6), be used for adjusting beam spot shape on target, by tumor area
Multi-leaf optical grating (7) that overseas proton beam card falls, for the degree of depth according to patient tumors and the trouble of Adjusting Shape beam energy
Person's compensator (8).
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610614055.0A CN106075748B (en) | 2016-07-29 | 2016-07-29 | The device of oncotherapy is carried out using wobbling magnet diffusion proton beam |
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|---|---|---|---|
| CN201610614055.0A CN106075748B (en) | 2016-07-29 | 2016-07-29 | The device of oncotherapy is carried out using wobbling magnet diffusion proton beam |
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| CN106075748A true CN106075748A (en) | 2016-11-09 |
| CN106075748B CN106075748B (en) | 2018-10-09 |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110152029A (en) * | 2018-11-02 | 2019-08-23 | 深圳铭杰医疗科技有限公司 | A kind of line needle chlorination equipment based on magnetic field |
| CN114470535A (en) * | 2022-01-20 | 2022-05-13 | 中国原子能科学研究院 | Boron neutron capture treatment beam line layout structure |
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| CN1107374A (en) * | 1994-02-26 | 1995-08-30 | 宋世鹏 | Rotary focus type radioactive therapeutic apparatus |
| US6717162B1 (en) * | 1998-12-24 | 2004-04-06 | Ion Beam Applications S.A. | Method for treating a target volume with a particle beam and device implementing same |
| CN1919373A (en) * | 2005-08-25 | 2007-02-28 | 惠小兵 | Radiation therapeutical device |
| CN1919374A (en) * | 2005-08-25 | 2007-02-28 | 惠小兵 | Radiation therapeutical irradiation device |
| WO2008011900A1 (en) * | 2006-07-27 | 2008-01-31 | Deutsches Krebsforschungszentrum Stiftung des öffentlichen Rechts | Irradiation device and collimator |
| CN101778528A (en) * | 2010-03-09 | 2010-07-14 | 中国原子能科学研究院 | Method and device for high homogenization of beam current |
| CN205073541U (en) * | 2015-09-28 | 2016-03-09 | 南京中硼联康医疗科技有限公司 | A beam diagnostic system for neutron capture treatment system |
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2016
- 2016-07-29 CN CN201610614055.0A patent/CN106075748B/en active Active
Patent Citations (7)
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|---|---|---|---|---|
| CN1107374A (en) * | 1994-02-26 | 1995-08-30 | 宋世鹏 | Rotary focus type radioactive therapeutic apparatus |
| US6717162B1 (en) * | 1998-12-24 | 2004-04-06 | Ion Beam Applications S.A. | Method for treating a target volume with a particle beam and device implementing same |
| CN1919373A (en) * | 2005-08-25 | 2007-02-28 | 惠小兵 | Radiation therapeutical device |
| CN1919374A (en) * | 2005-08-25 | 2007-02-28 | 惠小兵 | Radiation therapeutical irradiation device |
| WO2008011900A1 (en) * | 2006-07-27 | 2008-01-31 | Deutsches Krebsforschungszentrum Stiftung des öffentlichen Rechts | Irradiation device and collimator |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110152029A (en) * | 2018-11-02 | 2019-08-23 | 深圳铭杰医疗科技有限公司 | A kind of line needle chlorination equipment based on magnetic field |
| CN114470535A (en) * | 2022-01-20 | 2022-05-13 | 中国原子能科学研究院 | Boron neutron capture treatment beam line layout structure |
| CN114470535B (en) * | 2022-01-20 | 2022-12-09 | 中国原子能科学研究院 | Boron neutron capture treatment beam line layout structure |
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| CN106075748B (en) | 2018-10-09 |
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