CN106075249A - A kind of medicine treating periodontitis and preparation method - Google Patents

A kind of medicine treating periodontitis and preparation method Download PDF

Info

Publication number
CN106075249A
CN106075249A CN201610624081.1A CN201610624081A CN106075249A CN 106075249 A CN106075249 A CN 106075249A CN 201610624081 A CN201610624081 A CN 201610624081A CN 106075249 A CN106075249 A CN 106075249A
Authority
CN
China
Prior art keywords
parts
herba
radix
thunb
medicine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
CN201610624081.1A
Other languages
Chinese (zh)
Inventor
郭志平
Original Assignee
郭志平
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 郭志平 filed Critical 郭志平
Priority to CN201610624081.1A priority Critical patent/CN106075249A/en
Publication of CN106075249A publication Critical patent/CN106075249A/en
Withdrawn legal-status Critical Current

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/88Liliopsida (monocotyledons)
    • A61K36/906Zingiberaceae (Ginger family)
    • A61K36/9062Alpinia, e.g. red ginger or galangal
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K33/00Medicinal preparations containing inorganic active ingredients
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/28Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/33Cactaceae (Cactus family), e.g. pricklypear or Cereus
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/39Convolvulaceae (Morning-glory family), e.g. bindweed
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/48Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/53Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/67Piperaceae (Pepper family), e.g. Jamaican pepper or kava
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/70Polygonaceae (Buckwheat family), e.g. spineflower or dock
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/74Rubiaceae (Madder family)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/77Sapindaceae (Soapberry family), e.g. lychee or soapberry
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/81Solanaceae (Potato family), e.g. tobacco, nightshade, tomato, belladonna, capsicum or jimsonweed
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/88Liliopsida (monocotyledons)
    • A61K36/896Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/88Liliopsida (monocotyledons)
    • A61K36/898Orchidaceae (Orchid family)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K2236/00Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30Extraction of the material
    • A61K2236/31Extraction of the material involving untreated material, e.g. fruit juice or sap obtained from fresh plants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K2236/00Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30Extraction of the material
    • A61K2236/33Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/331Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K2236/00Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30Extraction of the material
    • A61K2236/33Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/333Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K2236/00Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30Extraction of the material
    • A61K2236/39Complex extraction schemes, e.g. fractionation or repeated extraction steps
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K2236/00Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/50Methods involving additional extraction steps
    • A61K2236/51Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying

Abstract

The invention discloses a kind of medicine treating periodontitis and preparation method, belong to the field of Chinese medicines;The raw material of effective ingredient of the present invention consists of: Bulbus scillae scilloidis, xanthorrhiza, Cephalanthera falcata (Thunb) Lindl, Herba Solani Surattensis, Herba rhynchosiae volubilis, Maifanitum, Radix Rumicis Patientiae, Alpinia japonica (Thunb.) Miq., Radix embeliae laetae, Fructus nephelii topengii, Herba Osbeckiae, Herba Carpesii Cernui, Radix et Caulis Opuntiae Dillenii, Herba Spilanthis callimorphae, Fructus Piperis Longi and Radix Serissae;Selected by medicine of the present invention, medical material compatibility is suitable, meets Chinese medicine and pharmacy and modern medicine theory, and has effect of removing food stagnancy eliminating stagnation, relaxing muscles and tendons and activating QI and blood in the collateral, reducing swelling and alleviating pain, the various symptoms causing treatment periodontitis have unique curative effect, and evident in efficacy, short treating period, instant effect, non-relapse after healing, taking convenience, without any side effects, it is possible to reach the purpose for the treatment of both the principal and secondary aspects of a disease, special effect is practical, wide popularization and application on clinic.

Description

A kind of medicine treating periodontitis and preparation method
Art
The present invention relates to the field of Chinese medicines, particularly relate to a kind of medicine treating periodontitis and preparation method.
Background technology
The chronic inflammatory disease of the Periodontal Supporting Tissue that periodontitis is mainly caused by local factor, age of onset is with after 35 years old The most common, as gingivitis fails to treat in time, inflammation can be diffused into periodontal membrane, alveolar bone and cementum by gingiva to deep layer and send out Exhibition is periodontitis, due to the most the most out in the cold without obvious subjective symptoms, the most more serious in time having symptom, the most can not protect Stay tooth.
Early symptom is inconspicuous, patient's often only Secondary cases gingival hemorrhage or performance of halitosis, similar to symptoms of gingivitis, inspection Visible gum edge, gum nipple and the swelling of attached gingiva when looking into, matter are soft, in peony or kermesinus, visit examine the most hemorrhage.Along with inflammation Further diffusion, following symptoms occurs: periodontal pocket is formed due to the extension of inflammation, and periodontal membrane is destroyed, and alveolar bone is gradually inhaled Receiving, gingiva separates with root of the tooth, makes gingival sulcus deepen and form periodontal pocket.Depth of pocket surveyed by available probe;Periodontal pyorrhea periodontal pocket Wall has ulcer and struvite granulation tissue to be formed, and has purulent secretion to retain in bag, therefore flicking gingiva, it is seen that pyorrhea, and often have Halitosis;Odontoseisis is destroyed due to periodontal tissue, when particularly frontal resorption increases the weight of, supports that tooth strength is not enough, occurs The phenomenon such as odontoseisis, displacement.Now patient often feels unable, the dull pain of occlusion, and gingival hemorrhage and halitosis increase the weight of;Work as Abwehrkraft des Koepers When reduction, periodontal pocket sepage inadequate drainage, periodontal abscess can be formed, be that periodontitis develops into late period, occur the one of deep periodontal pocket Individual common concomitant symptom.Now gingiva is oval projection, rubescent swelling, surface-brightening;Tooth mobility increases, and kowtows Bitterly;Patient is with local acutely jumping pain.Meanwhile, patient can have body temperature to raise, general malaise, submandibular lymph nodes enlargement, toothache etc. Symptom.
At present, both at home and abroad the medicine for the treatment of periodontitis is more, the most all uses Western medicine and treatment by Chinese herbs, but most drug There is the shortcomings such as price is high, toxic and side effects is big, therapeutic effect is the best.
Summary of the invention
The invention provides a kind of medicine treating periodontitis and preparation method;Medical material compatibility phase selected by medicine of the present invention Preferably, meet Chinese medicine and pharmacy and modern medicine theory, and there is effect of removing food stagnancy eliminating stagnation, relaxing muscles and tendons and activating QI and blood in the collateral, reducing swelling and alleviating pain, to treatment The various symptoms that periodontitis causes have unique curative effect, and evident in efficacy, short treating period, instant effect, non-relapse after healing, the side of taking Just, without any side effects, it is possible to reach the purpose for the treatment of both the principal and secondary aspects of a disease, special effect is practical, wide popularization and application on clinic.
For achieving the above object, technical scheme is implemented as follows:
A kind of medicine treating periodontitis, make described effective ingredient raw material composition and parts by weight be:
Make described effective ingredient raw material composition and parts by weight be:
Make described effective ingredient raw material composition and parts by weight be:
Make described effective ingredient raw material composition and parts by weight be:
The preparation method of a kind of medicine treating periodontitis, comprises the following steps that:
(1) Bulbus scillae scilloidis, Cephalanthera falcata (Thunb) Lindl, Herba rhynchosiae volubilis, Radix Rumicis Patientiae, Alpinia japonica (Thunb.) Miq., Fructus nephelii topengii, Fructus Piperis Longi and Radix Serissae are cleaned, put into container, add Enter the distilled water of 8~10 times amount, after soaking 5~6 hours, boil 3~4 hours, extract;Again add 6~8 times amount distilled water, Boil 2~3 hours, extract;Finally, add 4~6 times amount distilled water, heated and boiled 1~2 hours, extract;Merge three extractions Liquid, filters, obtains filtrate, and being condensed into relative density at 60 DEG C is the thick paste of 1.10~1.13, standby;
(2) xanthorrhiza, Radix et Caulis Opuntiae Dillenii and Herba Spilanthis callimorphae are cleaned, immerse 4 times amount 60% alcohol solution dipping 1~2 hours, add Heat is extracted 3 hours, reclaims ethanol, filters, obtains filtrate, and concentration is that at 65 DEG C, relative density is the thick paste of 1.12~1.15, standby;
(3) Herba Solani Surattensis and Maifanitum are put into container, carry out pulverization process, grind into powder, obtain 180 mesh fine powders, standby;
(4) Radix embeliae laetae, Herba Osbeckiae and Herba Carpesii Cernui are cleaned, chopping, put into container, twist juice, filter impurity, stay juice standby With;
(5) thick paste, fine powder and the juice obtained by above-mentioned steps (1)~(4) is made tablet, obtain described treatment The medicine of periodontitis.
The property of medicine of Chinese medicine used by the present invention is as follows:
Bulbus scillae scilloidis: sweet in the mouth, hardship, cold in nature.Heart tonifying diuresis, reducing swelling and alleviating pain, removing toxic substances.For traumatic injury, lumbago and skelalgia, muscles and bones Bitterly, toothache, heart disease edema;Carbuncle, mastitis, venom are controlled in external.Soviet Union doctor " Chinese herbal medicine handbook " carries: " invigorate blood circulation, detumescence, Removing toxic substances, pain relieving.Control traumatic injury, lumbago and skelalgia, bones and muscles pain;Fresh bulb is mashed external application and is controlled carbuncle, mastitis.”
Xanthorrhiza: mildly bitter flavor, cool in nature.Cooling blood for hemostasis, dampness removing jaundice eliminating.For leukemia, aplastic anemia, gingiva goes out Blood, hepatitis, urinary tract infection.Modern medicine study confirm, with dilute alcohol reflux extraction xanthorrhiza preparation, to staphylococcus aureus, Anthrax bacillus has height antibacterial action, to group B streptococcus, streptococcus pneumoniae, Bacillus typhi, diphtheria corynebacterium and Fu Shi dysentery bar Bacterium has moderate antibacterial action.
Cephalanthera falcata (Thunb) Lindl: sweet in the mouth, cold in nature;Return Liver Channel.Clearing away heat-fire, removing toxic substances.Cure mainly laryngopharynx swelling and pain, toothache, venom." Xinhua Book on Chinese herbal medicine outline " carry: " herb, has heat clearing away, the function of pathogenic fire purging.For having sore throat, having a toothache.”
Herba Solani Surattensis: bitter in the mouth, cold in nature, under rushing down, antidote against snake bite.Cure mainly constipation, venom." the southern regions of the Yunnan Province book on Chinese herbal medicine " carries: " control tooth Toothache, is coated with it for end.Treat nasal sinusitis, dispel the wind, only headache, exorcising.”
Herba rhynchosiae volubilis: bitter in the mouth, pungent, property is put down.Removing food stagnancy eliminating stagnation, reducing swelling and alleviating pain, relaxing muscles and tendons and activating QI and blood in the collateral.For infantile malnutrition, toothache, nerve Headache, lymphoid tuberculosis, rheumatic arthritis, lumbar muscle strain;Carbuncle furuncle and phyma poison, venom are controlled in external.Jiangxi " medical herbs handbook " carries: " eliminate the phlegm, removing toxic substances, parasite killing, wind-damp dispelling, and vim and vigour, control acute appendicitis, scrofula, headache, ophthalmalgia, stomachache.”
Maifanitum: sweet in the mouth, warm in nature, nontoxic;Return liver, stomach, kidney channel.Detoxicating and resolving stagnation of pathogens, removing the necrotic tissue and promoting granulation, except cold damp eliminating, the liver benefiting is good for Stomach, blood circulation promoting and blood stasis dispelling, diuresis fossil, life lengthening.Curing mainly carbuncle carbuncle on the back, acne, eczema, tinea pedis, miliaria, finger is chapped, yellowish-brown Speckle, toothache, oral ulcer, rheumatic arthralgia, lumbago and backache, chronic hepatitis, gastritis, dysentery, diabetes, neurasthenia, wound is red and swollen, Hypertension, senile sclerosis of blood vessels, tumor, lithangiuria.
Radix Rumicis Patientiae: bitter in the mouth, acid, cold in nature.Cooling blood for hemostasis, heat-clearing and toxic substances removing, parasite killing.For dysfunctional uterine hemorrhage, spit blood, cough up Blood, epistaxis, gingival hemorrhage, tail, duodenal hemorrhage, have blood in stool, purpura, constipation, edema;Scabies, furuncle, seborrheica skin are controlled in external Scorching." Shaanxi Chinese herbal medicine " carries: " promoting blood circulation to remove blood stasis, hemostasis, heat-clearing and toxic substances removing, loosening bowel to relieve constipation.Control traumatic injury;Internal hemorrhage, purpura disease, Burn, axil kitchen skin ulcer, tinea, appendicitis, chronic enteritis, constipation.”
Alpinia japonica (Thunb.) Miq.: acrid in the mouth, warm in nature.Dispelling wind and removing obstruction in the collateral, regulating QI to relieve pain.For rheumatic arthritis, traumatic injury, toothache, stomachache. " vegetation just side " carries: " solve big poison, promoting the circulation of blood repercussive, saturating muscles and bones.Dispelling the wind and dampness pathogens numb limbs and tense tendons, apoplexy insensitive impediment.”
Radix embeliae laetae: sour in the mouth, puckery, cool in nature.Heat-clearing and toxic substances removing, dissipating blood stasis stops blooding.Control laryngopharynx swelling and pain, gingiva bleeding gingival hemorrhage, diarrhea due to hypofunction of the spleen, fall Beat stasis of blood pain, hemorrhoid." Luchuan book on Chinese herbal medicine " carries: " antiinflammatory, sterilization.Control stomatitis, laryngitis, gingivitis, furuncle ulcer etc..And Xie great Cha Poison of drug, wood eat poison, Fructus Crotonis poison.”
Fructus nephelii topengii: sweet in the mouth, acid, warm in nature;Return spleen, stomach warp.Cold expelling, dysentery relieving, removing toxic substances.Main dysentery, trusted subordinate's cold type of pain, skin infection." Luchuan Book on Chinese herbal medicine " carry: " anti-inflammation and sterilization.Control stomatitis, dysentery, wash ulcer.”
Herba Osbeckiae: acrid in the mouth, light, property is put down;Return lung, spleen, liver, large intestine channel.Reduce phlegm dampness removing, hemostasis by removing blood stasis, removing toxic substances and promoting subsidence of swelling.Master coughs Cough, asthma, dysentery, have loose bowels, spit blood, spitting of blood, have blood in stool, amenorrhea, infantile malnutrition, rheumatic ostalgia, traumatic injury." Nanning City's medicine will " Carry: " eliminating blood stasis to promote regeneration of blood, pain relieving restrains.Control interior external haemorrhage, infantile malnutrition, ulcerative gingivitis, toothache, cough.”
Herba Carpesii Cernui: bitter in the mouth, pungent, cold in nature.Heat-clearing and toxic substances removing, reducing swelling and alleviating pain.For cold, fever, laryngopharynx swelling and pain, have a toothache, acute Enteritis, dysentery, urinary tract infection, tuberculous lymphadenitis;Furuncle toxic swelling, mastitis, parotitis, herpes zoster, venom are controlled in external.
Radix et Caulis Opuntiae Dillenii: bitter in the mouth, cool in nature.Heat-clearing and toxic substances removing, dissipating blood stasis for subsidence of swelling, benefiting stomach and stopping pain, antitussive.For taste-blindness rate, Acute dysentery, cough;Mumps, mastitis, carbuncle furuncle and phyma poison, venom, burn and scald are controlled in external." east, Fujian book on Chinese herbal medicine " carries: " energy blood stasis removing, intestinal detoxication, stomach invigorating, pain relieving, nourishing, relaxing muscles and tendons and activating QI and blood in the collateral, hemostasis of curing the wound.Control hemorrhoidal hamorrhage anal fistula hematochezia, lung abscess, stomachache, traumatic injury Damage.”
Herba Spilanthis callimorphae: acrid in the mouth, hardship, warm in nature.Expelling wind and removing dampness, eliminating stasis to stop pain.For fracturing, traumatic injury, rheumatic arthritis is logical Warp, cold syndrome of the stomach pain, toothache, cold, traumatic hemorrhage." Yunnan Chinese herbal medicine " carries: " pain relieving, blood circulation promoting and blood stasis dispelling.Controlling fracture, traumatic injury damages Wound, rheumatic arthritis, amenorrhea, cold syndrome of the stomach pain.”
Fructus Piperis Longi: acrid in the mouth, property heat;Return stomach, large intestine channel.Warming spleen and stomach for dispelling cold, therapeutic method to keep the adverse QI flowing downwards pain relieving.For coldness and pain in the epigastrium, vomiting, have loose bowels, Migraine, external treatment is had a toothache." detailed outline " carries: " Fructus Piperis Longi for headache, nasal sinusitis, toothache key medicine, takes it and hot can enter Yangming Channel and dissipate superficial heat Also.”
Radix Serissae: bitter in the mouth, pungent, cool in nature;Return liver, spleen channel.Expelling wind and removing dampness, heat-clearing and toxic substances removing.Cure mainly flu, icterohepatitis, Oedema due to nephritis, cough, laryngalgia, keratitis, enteritis, dysentery, lumbago and skelalgia, hemoptysis, hematuria, women's amenorrhea, leucorrhea, children's's infantile malnutrition Long-pending, infantile convulsion, acute toothache, swollen ulcer drug, traumatic injury." Guizhou folk medicine " carries: " heat-clearing and toxic substances removing, soothing the channels and quicking the network vessels.Control cutter Wound, paralysis, the weak disease of men and women, fly furuncle.”
The present invention compared with prior art, has the advantages that
Selected by medicine of the present invention, medical material compatibility is suitable, meets Chinese medicine and pharmacy and modern medicine theory, and it is scattered to have removing food stagnancy Knot, relaxing muscles and tendons and activating QI and blood in the collateral, effect of reducing swelling and alleviating pain, the various symptoms causing treatment periodontitis have unique curative effect, and evident in efficacy, Short treating period, instant effect, non-relapse after healing, taking convenience, without any side effects, it is possible to reach the purpose for the treatment of both the principal and secondary aspects of a disease, very Effect practicality, wide popularization and application on clinic.
Detailed description of the invention
Below in conjunction with specific embodiment, the present invention is further elaborated.
Embodiment 1
The raw material of effective ingredient of the present invention forms and weight is:
The preparation method of a kind of medicine treating periodontitis, comprises the following steps that:
(1) Bulbus scillae scilloidis, Cephalanthera falcata (Thunb) Lindl, Herba rhynchosiae volubilis, Radix Rumicis Patientiae, Alpinia japonica (Thunb.) Miq., Fructus nephelii topengii, Fructus Piperis Longi and Radix Serissae are cleaned, put into container, add Enter the distilled water of 8~10 times amount, after soaking 5~6 hours, boil 3~4 hours, extract;Again add 6~8 times amount distilled water, Boil 2~3 hours, extract;Finally, add 4~6 times amount distilled water, heated and boiled 1~2 hours, extract;Merge three extractions Liquid, filters, obtains filtrate, and being condensed into relative density at 60 DEG C is the thick paste of 1.10~1.13, standby;
(2) xanthorrhiza, Radix et Caulis Opuntiae Dillenii and Herba Spilanthis callimorphae are cleaned, immerse 4 times amount 60% alcohol solution dipping 1~2 hours, add Heat is extracted 3 hours, reclaims ethanol, filters, obtains filtrate, and concentration is that at 65 DEG C, relative density is the thick paste of 1.12~1.15, standby;
(3) Herba Solani Surattensis and Maifanitum are put into container, carry out pulverization process, grind into powder, obtain 180 mesh fine powders, standby;
(4) Radix embeliae laetae, Herba Osbeckiae and Herba Carpesii Cernui are cleaned, chopping, put into container, twist juice, filter impurity, stay juice standby With;
(5) thick paste, fine powder and the juice obtained by above-mentioned steps (1)~(4) is made tablet, obtain described treatment The medicine of periodontitis.
Usage and dosage: oral, every day 2 times, the most each 1 time, each 1 (every 0.5g), warm water delivery service after meal; Within 5 days, being 1 course for the treatment of, can fully recover 2~3 courses for the treatment of, the person of being in a bad way follows the doctor's advice the meal with wine amount of adding.
Embodiment 2
The raw material of effective ingredient of the present invention forms and weight is:
The process for preparing medicine processing step of the present embodiment and usage and dosage are same as in Example 1.
Embodiment 3
The raw material of effective ingredient of the present invention forms and weight is:
The process for preparing medicine processing step of the present embodiment and usage and dosage are same as in Example 1.
Embodiment 4
The raw material of effective ingredient of the present invention forms and weight is:
The process for preparing medicine processing step of the present embodiment and usage and dosage are same as in Example 1.
Embodiment 5
The raw material of effective ingredient of the present invention forms and weight is:
The process for preparing medicine processing step of the present embodiment and usage and dosage are same as in Example 1.
Clinical data:
1, case selection:
As the medicine for the treatment of periodontitis, selecting the patients with periodontitis 208 example clinical observation made a definite diagnosis, patient is randomly divided into and controls Treatment group and matched group two groups, treatment group 104 example, wherein male 52 example, women 52 example, age 36~69 years old, the mean age 52.5 Year, average course of disease 2 years;Matched group 104 example, wherein male 52 example, women 52 example, age 37~68 years old, 52.5 years old mean age, Average course of disease 2 years.
Treatment group and the course of disease of two groups of cases of matched group, degrees of symptoms are basically identical, without significant difference, have comparable Property.
2, medicament selection:
Treatment group takes medicine of the present invention, oral, every day 2 times, the most each 1 time, each 1 (every 0.5g), meal Rear warm water delivery service;Within 5 days, being 1 course for the treatment of, can fully recover 2~3 courses for the treatment of, the person of being in a bad way follows the doctor's advice the meal with wine amount of adding.
Matched group takes spiramycin, oral, one time 6, point take for 2~3 times, severe infection patient dose can be followed the doctor's advice Increase to one day 8.
3, efficacy determination:
(1) cure: submandibular lymph nodes enlargement, toothache symptom all disappear, and tooth recovers normal.
(2) effective: above-mentioned symptom substantially alleviates, tooth is clearly better.
(3) effective: above-mentioned symptom has alleviated, and tooth has taken a turn for the better.
(4) invalid: by above-mentioned symptom after treatment without alleviating or increasing the weight of.
4, result:
Select in the treatment group of medicine of the present invention, cure 59 examples, effective 28 examples, effective 14 examples, invalid 3 examples, cure rate 56.7%, total effective rate 97.1%.
Matched group is cured 50 examples, effective 20 examples, effective 11 examples, invalid 23 examples, cure rate 48.1%, total effective rate 77.9%.
Result above shows, the cure rate for the treatment of group and total effective rate are apparently higher than matched group.
Model case is illustrated:
1, Bai, female, 38 years old, people from Nanchang.Patient, because not noting tooth hygiene for a long time, suffers from periodontitis more than 1 year, uses Crossing multiple Drug therapy, therapeutic effect is general, and relapse rate is high, takes Drug therapy of the present invention, and after taking 1 course for the treatment of, symptom is bright Showing and alleviate, after continuing to take 2 courses for the treatment of, symptom is all cured, and follows up a case by regular visits to not recur so far.
2, health, man, 40 years old, Tongchuan, Shaanxi Province people.Patient, because of individual's reason, causes getting angry, and tooth often aches, and uses several medicine Thing is treated, and has only served temporary pain relieving, will recur after a time, it is impossible to cure.The most to our hospital, take medicine of the present invention Thing is treated, and after taking 1 course for the treatment of, symptom has been alleviated, after taking 2 courses for the treatment of, and transference cure, recovery from illness, follow up a case by regular visits to after 1 year without multiple Send out.
3, Qiu, man, 39 years old, people from Luohe, Henan.Patient's red swelling of gingiva is congested, and that touches is hemorrhage, depth of pocket 3mm, overflows Pus, odontoseisis, knocking pain, implication heat is smelly, constipation, yellowish or reddish urine, goes examination in hospital to be diagnosed as periodontitis, gives this Invention Drug therapy, after taking 1 course for the treatment of, symptom is clearly better, and after taking 2 courses for the treatment of, symptom all disappears, and recovery from illness, after 2 years Follow up a case by regular visits to without recurrence.
4, river, female, 42 years old, Shantou, Guangdong people.Patient's lower front tooth gingival enlargement, the II degree touched loosens, the halitosis of news, stool Dry, red tongue, yellow fur is thick, is diagnosed as periodontitis.Taking Drug therapy of the present invention, after taking 1 course for the treatment of, symptom has been alleviated, After taking 3 courses for the treatment of, symptom all disappears, recovery from illness, follows up a case by regular visits to not recur so far.
5, history, female, 50 years old, people from Jinzhou, Liaoning.Patient's red swelling of gingiva is congested, goes examination in hospital to suffer from periodontitis, uses Crossing several drugs treatment, therapeutic effect is the best, takes Drug therapy of the present invention, and after taking 1 course for the treatment of, symptom substantially alleviates, and continues Continue after taking 1 course for the treatment of, transference cure, recovery from illness, follow up a case by regular visits to after half a year without recurrence.
6, certain is turned round and look at, man, 47 years old, people from Yongchuan District, Chongqing.Patient's door red swelling of gingiva, touches hemorrhage, lower front tooth gingival enlargement, goes doctor Institute is diagnosed as periodontitis, uses several drugs to treat, and therapeutic effect is poor, introduces through friend and takes Drug therapy of the present invention, After taking 1 course for the treatment of, symptom has alleviated, and after continuing to take 2 courses for the treatment of, symptom all disappears, recovery from illness, follows up a case by regular visits to so far without multiple Send out.

Claims (5)

1. the medicine treating periodontitis, it is characterised in that: make raw material composition and the weight portion of described effective ingredient Number is:
Bulbus scillae scilloidis 27~51 parts of xanthorrhizas 27~51 parts of Cephalanthera falcata (Thunb) Lindl 26~50 parts of Herba Solani Surattensiss 26~50 parts
Herba rhynchosiae volubilis 24~48 parts of Maifanitums 22~46 parts of Radix Rumicis Patientiae 22~46 parts of Alpinia japonica (Thunb.) Miq.s 21~45 parts
Radix embeliae laetae 20~44 parts of Fructus nephelii topengii 20~44 parts of Herba Osbeckiaes 17~41 parts of Herba Carpesii Cernui 16~40 parts
Radix et Caulis Opuntiae Dillenii 16~40 parts of Herba Spilanthis callimorphaies 15~37 parts of Fructus Piperis Longi 14~32 parts of Radix Serissae 12~29 parts.
A kind of medicine treating periodontitis the most according to claim 1, it is characterised in that: make described effective ingredient Raw material composition and parts by weight be:
Bulbus scillae scilloidis 31~47 parts of xanthorrhizas 31~47 parts of Cephalanthera falcata (Thunb) Lindl 30~46 parts of Herba Solani Surattensiss 30~46 parts
Herba rhynchosiae volubilis 28~44 parts of Maifanitums 26~42 parts of Radix Rumicis Patientiae 26~42 parts of Alpinia japonica (Thunb.) Miq.s 25~41 parts
Radix embeliae laetae 24~40 parts of Fructus nephelii topengii 24~40 parts of Herba Osbeckiaes 21~37 parts of Herba Carpesii Cernui 20~36 parts
Radix et Caulis Opuntiae Dillenii 20~36 parts of Herba Spilanthis callimorphaies 19~33 parts of Fructus Piperis Longi 17~29 parts of Radix Serissae 15~27 parts.
A kind of medicine treating periodontitis the most according to claim 1, it is characterised in that: make described effective ingredient Raw material composition and parts by weight be:
Bulbus scillae scilloidis 35~43 parts of xanthorrhizas 35~43 parts of Cephalanthera falcata (Thunb) Lindl 34~42 parts of Herba Solani Surattensiss 34~42 parts
Herba rhynchosiae volubilis 32~40 parts of Maifanitums 30~38 parts of Radix Rumicis Patientiae 30~38 parts of Alpinia japonica (Thunb.) Miq.s 29~37 parts
Radix embeliae laetae 28~36 parts of Fructus nephelii topengii 28~36 parts of Herba Osbeckiaes 25~33 parts of Herba Carpesii Cernui 24~32 parts
Radix et Caulis Opuntiae Dillenii 24~32 parts of Herba Spilanthis callimorphaies 23~29 parts of Fructus Piperis Longi 20~26 parts of Radix Serissae 18~24 parts.
A kind of medicine treating periodontitis the most according to claim 1, it is characterised in that: make described effective ingredient Raw material composition and parts by weight be:
39 parts of xanthorrhizas of Bulbus scillae scilloidis, 38 parts of Herba Solani Surattensiss of 39 parts of Cephalanthera falcata (Thunb) Lindl 38 parts
36 parts of Maifanitums of Herba rhynchosiae volubilis, 34 parts of Alpinia japonica (Thunb.) Miq.s of 34 parts of Radix Rumicis Patientiae 33 parts
32 parts of Fructus nephelii topengii of Radix embeliae laetae, 29 parts of Herba Carpesii Cernui of 32 parts of Herba Osbeckiaes 28 parts
28 parts of Herba Spilanthis callimorphaies of Radix et Caulis Opuntiae Dillenii, 23 parts of Radix Serissae of 26 parts of Fructus Piperis Longi 21 parts.
5. the preparation method of the medicine treating periodontitis as described in any one of Claims 1 to 4, it is characterised in that: include Following processing step:
(1) Bulbus scillae scilloidis, Cephalanthera falcata (Thunb) Lindl, Herba rhynchosiae volubilis, Radix Rumicis Patientiae, Alpinia japonica (Thunb.) Miq., Fructus nephelii topengii, Fructus Piperis Longi and Radix Serissae are cleaned, put into container, add 8 ~10 distilled water of times amount, after soaking 5~6 hours, boil 3~4 hours, extract;Again add 6~8 times amount distilled water, boil 2~3 hours, extract;Finally, add 4~6 times amount distilled water, heated and boiled 1~2 hours, extract;Merge three extracting solution, mistake Filter, obtains filtrate, and being condensed into relative density at 60 DEG C is the thick paste of 1.10~1.13, standby;
(2) xanthorrhiza, Radix et Caulis Opuntiae Dillenii and Herba Spilanthis callimorphae are cleaned, immerse 4 times amount 60% alcohol solution dipping 1~2 hours, heating carries Taking 3 hours, reclaim ethanol, filter, obtain filtrate, concentration is that at 65 DEG C, relative density is the thick paste of 1.12~1.15, standby;
(3) Herba Solani Surattensis and Maifanitum are put into container, carry out pulverization process, grind into powder, obtain 180 mesh fine powders, standby;
(4) Radix embeliae laetae, Herba Osbeckiae and Herba Carpesii Cernui are cleaned, chopping, put into container, twist juice, filter impurity, stay juice standby;
(5) thick paste, fine powder and the juice obtained by above-mentioned steps (1)~(4) is made tablet, obtain described treatment periodontal Scorching medicine.
CN201610624081.1A 2016-07-29 2016-07-29 A kind of medicine treating periodontitis and preparation method Withdrawn CN106075249A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN201610624081.1A CN106075249A (en) 2016-07-29 2016-07-29 A kind of medicine treating periodontitis and preparation method

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN201610624081.1A CN106075249A (en) 2016-07-29 2016-07-29 A kind of medicine treating periodontitis and preparation method

Publications (1)

Publication Number Publication Date
CN106075249A true CN106075249A (en) 2016-11-09

Family

ID=57478686

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201610624081.1A Withdrawn CN106075249A (en) 2016-07-29 2016-07-29 A kind of medicine treating periodontitis and preparation method

Country Status (1)

Country Link
CN (1) CN106075249A (en)

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1170580A (en) * 1996-07-17 1998-01-21 董广安 Chinese drug composition for curing periodontitis
CN1322533A (en) * 2000-05-12 2001-11-21 丁南普 Chinese medicine composition preparation for treating alveolysis

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1170580A (en) * 1996-07-17 1998-01-21 董广安 Chinese drug composition for curing periodontitis
CN1322533A (en) * 2000-05-12 2001-11-21 丁南普 Chinese medicine composition preparation for treating alveolysis

Similar Documents

Publication Publication Date Title
CN103505656B (en) Chinese medicine preparation for treating stomatitis
CN103463494B (en) One treats hypertensive Chinese medicine preparation
CN103041341B (en) Traditional Chinese medicine composition for curing tuberculous exadative pleurisy and preparation method thereof
CN104547714B (en) Chinese traditional medicine for treating periodontitis and preparation method thereof
CN103495099B (en) Chinese medicine preparation for nursing patient with toothache and preparation method thereof
CN105616805A (en) Traditional Chinese medicine preparation used for mastitis nursing and preparation method
CN103877336B (en) A kind of Traditional Chinese medicine lozenge and preparation method for the treatment of laryngopharynx swelling and pain
CN104547384A (en) Oral liquid for treating paraquat poisoning and preparation method of oral liquid
CN104623217A (en) Traditional Chinese medicine preparation for treating asthma and preparation method thereof
CN104257986A (en) Traditional Chinese medicine for treating nephritis
CN104225405A (en) Chinese medicinal buccal tablet for treating respiratory tract infection and preparation method
CN103893610A (en) Traditional Chinese medicine ointment for treating tinea of feet and hands and preparation method thereof
CN103877390A (en) Traditional-Chinese-medicine preparation for treating rheumatic fever and preparation method thereof
CN104189608B (en) Traditional Chinese medicine preparation for recurrent oral ulcer and preparation method thereof
CN106075249A (en) A kind of medicine treating periodontitis and preparation method
CN103550656B (en) Traditional Chinese medicine preparation for treating toothache
CN103721028B (en) One treats anginal medicine and preparation method
CN105288195A (en) Medicine for treating thyroiditis and preparation method for medicine
CN103638369B (en) Traditional Chinese medicinal preparation for treating mastitis
CN105663959A (en) Traditional Chinese medicine preparation for nursing patient suffering from toothache and preparation method
CN105687956A (en) Traditional Chinese medicine ointment for treating allergic dermatitis and preparation method
CN105055687A (en) Medicine for treating appendicitis and preparing method
CN104666911A (en) Medicine for treating urticaria and preparation method thereof
CN104338034A (en) Medicine for oral administration for treating ulcerative angina and preparation method thereof
CN103638233A (en) Traditional Chinese medicine composition for treating stomach fire up-flaming type periodontitis

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
WW01 Invention patent application withdrawn after publication

Application publication date: 20161109

WW01 Invention patent application withdrawn after publication