CN106074828A - A kind of Chinese medicine treating damp and hot poison Sheng type cancer of pancreas and preparation method - Google Patents
A kind of Chinese medicine treating damp and hot poison Sheng type cancer of pancreas and preparation method Download PDFInfo
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- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
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Abstract
The invention provides a kind of Chinese medicine treating damp and hot poison Sheng type cancer of pancreas and preparation method, the each raw medicinal material of Chinese medicine includes: Radix ardisiae brevicaulis, flexuose bittercress herb and seed, the grass that relieves internal heat, Herba Saussuseae Japonicae, concha Anodonta seu Cristaria grass, shoulder pole Artemisia, three-leaf tea, Radix Macropanacis Rosthornii, Herba Polygoni Capitati, Herba Hoyae Lyi, Radix craspedolobii schochii, Radix seu Folium Rubi Cochinchinensis, Herba Polycarpaeae Corymbosae, Herba Odontitis Serotinae and Folium seu Semen Daphniphylli oldhami.Beneficial effects of the present invention: Chinese medicine combined with chemotherapy of the present invention uses treatment damp and hot poison Sheng type cancer of pancreas, it is possible to is effectively improved the therapeutical effect of chemotherapy, reduces the side effect of chemotherapy simultaneously；Can the most quickly be mitigated or eliminated that epigastrium distension is uncomfortable or distending pain, jaundice, tired, loss of appetite, become thin, suffer from diarrhoea or the symptom such as constipation, alleviating patient suffering, stablize the state of an illness, while can extend the survival of patients phase.
Description
Technical field
The present invention relates to containing the medicinal preparation deriving from plant, animal or mineral component, particularly relate to a kind for the treatment of
The Chinese medicine of damp and hot poison Sheng type cancer of pancreas and preparation method.
Background technology
Cancer of pancreas is more rare in malignant tumor of digestive tract, is more common in 40～60 years old, and man is more than female, and cancer of pancreas mostly occurs
Diseases In Pancreatic Head, only minority occur in body of pancreas and tail of pancreas portion.Position and the morning and evening of the course of disease that cancer of pancreas occurs due to cancerous protuberance are different, clinical
Symptom is different.Stomachache is the symptom occurred the earliest, is more common in body of pancreas and tail of pancreas portion, and big multidirectional lower back radiates.The state of an illness is in development
During can have jaundice, may occur in which abdominal mass late period, heating, supraclavicular lymph nodes is modal metastasis site.Modern doctor
Think that primary disease may be relevant with carcinogen, coffee, smoking and chronic pancreatic diseases in environment.Cancer of pancreas is that one is the most fierce
The malignant tumor of danger, although in every 20,000 people of China, about 1 people suffers from cancer of pancreas, but this sick fast-growth case fatality rate is high.Beautiful
NIH of state reports, 1 year survival rate of cancer of pancreas is 8%, 5 years survival rates 3%.5 years survival rates of China's Statistical data
Only about 5%.Sickness rate significantly rises in recent years, and U.S.'s cancer of pancreas sickness rate increased 3 times between 10 years, within 2010, newly sends out
Sick 43140 examples, dead 36800 examples, occupy Incidence the tenth, mortality rate is but in the 4th.China's cancer of pancreas morbidity
With death toll ascendant trend highly significant especially.
Cancer of pancreas is in early days based on operative treatment, and postoperative suitable chemotherapy, in conjunction with long-term Chinese medicine, it is possible to obtain good
Good curative effect；Many operations palliative treatment in mid-term, such as unresectable, feasible cholecystojejunostomy to alleviate jaundice, simultaneously in
Medical treatment, it is possible to Combined with Radiotherapy, chemotherapy etc.；Late period is then based on Chinese medicine and symptomatic treatment, or combines small dose chemotherapy.
Cancer of pancreas belongs to the categories such as the traditional Chinese medical science " fullness in the epigastrium especially referring to the abcess of the abdomen in ancient times ", " mass in the abdomen ", " jaundice ", " accumulation ", and its cause of disease, pathogenesis are mainly seven emotions
Internal injury, eating and drinking without temperance and cause that liver spleen is impaired, internal organs are become estranged, turbid damp blocks, qi depression to blood stasis, with the passing of time form primary disease, in "Nei Jing" also
Have long been known that primary disease and diet delicious food and the relation of jaundice, as " Plain Questions is logical comments deficiency and excess opinion " is said: " diseases due to endogenous heat of ZANG FU organs sudden falling down, hemiplegia flaccidity
Fainting, fullness caused by stagnant QI is sent out inverse, sweet fertile high official, then the disease of Sorghum vulgare Pers. is also ".The traditional Chinese medical science thinks that primary disease is many by depression of liver-QI, caused by functional activity of QI being not smooth, the most then
Insufficiency of the spleen, insufficiency of the spleen resulting in production of dampness, strongly fragrant and heat-transformation, with the passing of time delay, then causes qi depression to blood stasis, knot in pyretic toxicity.
Summary of the invention
In order to solve above-mentioned technical problem, the invention provides a kind of Chinese medicine treating damp and hot poison Sheng type cancer of pancreas and preparation
Method, this Chinese medicine can be treated damp and hot poison Sheng type cancer of pancreas by combined with chemotherapy, be improved the therapeutical effect of chemotherapy, extend the existence of patient
Phase.
For solving above-mentioned technical problem, the invention provides in a kind of combination chemotherapeutic treatment stagnation of liver-QI intrinsic heat type cancer of pancreas
Medicine, each raw medicinal material of described Chinese medicine includes: Radix ardisiae brevicaulis, flexuose bittercress herb and seed, the grass that relieves internal heat, Herba Saussuseae Japonicae, concha Anodonta seu Cristaria grass, shoulder pole Artemisia, SANYE
Tea, Radix Macropanacis Rosthornii, Herba Polygoni Capitati, Herba Hoyae Lyi, Radix craspedolobii schochii, Radix seu Folium Rubi Cochinchinensis, Herba Polycarpaeae Corymbosae, Herba Odontitis Serotinae and Folium seu Semen Daphniphylli oldhami.
The ratio of weight and number of each raw medicinal material of described Chinese medicine can be preferably as follows: Radix ardisiae brevicaulis 10～20 parts, flexuose bittercress herb and seed
40～50 parts, relieve internal heat grass 5～15 parts, Herba Saussuseae Japonicae 15～25 parts, concha Anodonta seu Cristaria grass 55～65 parts, shoulder pole Artemisia 25～35 parts, three-leaf tea 15
～25 parts, Radix Macropanacis Rosthornii 5～15 parts, Herba Polygoni Capitati 40～50 parts, Herba Hoyae Lyi 5～15 parts, Radix craspedolobii schochii 55～65 parts, Radix seu Folium Rubi Cochinchinensis 10～20
Part, Herba Polycarpaeae Corymbosae 15～25 parts, Herba Odontitis Serotinae 10～20 parts and Folium seu Semen Daphniphylli oldhami 25～35 parts.
The ratio of weight and number of each raw medicinal material of described Chinese medicine can be preferably as follows: Radix ardisiae brevicaulis 10～15 parts, flexuose bittercress herb and seed
40～45 parts, relieve internal heat grass 5～10 parts, Herba Saussuseae Japonicae 15～20 parts, concha Anodonta seu Cristaria grass 55～60 parts, shoulder pole Artemisia 25～30 parts, three-leaf tea 15
～20 parts, Radix Macropanacis Rosthornii 5～10 parts, Herba Polygoni Capitati 40～45 parts, Herba Hoyae Lyi 5～10 parts, Radix craspedolobii schochii 55～60 parts, Radix seu Folium Rubi Cochinchinensis 10～15
Part, Herba Polycarpaeae Corymbosae 15～20 parts, Herba Odontitis Serotinae 10～15 parts and Folium seu Semen Daphniphylli oldhami 25～30 parts.
The ratio of weight and number of each raw medicinal material of described Chinese medicine can be preferably as follows: Radix ardisiae brevicaulis 11 parts, flexuose bittercress herb and seed 42 parts,
Relieve internal heat grass 6 parts, Herba Saussuseae Japonicae 18 parts, concha Anodonta seu Cristaria grass 59 parts, shoulder pole Artemisia 27 parts, three-leaf tea 16 parts, Radix Macropanacis Rosthornii 8 parts, Herba Polygoni Capitati 44 parts, stone
7 parts of straw sandals, 56 parts of Radix craspedolobii schochii, Radix seu Folium Rubi Cochinchinensis 10 parts, Herba Polycarpaeae Corymbosae 20 parts, Herba Odontitis Serotinae 13 parts and Folium seu Semen Daphniphylli oldhami 29 parts.
Present invention also offers the preparation method of above-mentioned Chinese medicine, the dosage form of described Chinese medicine is tablet, and its preparation method includes
Following steps:
The first step: be mixed in proportion by each for described Chinese medicine preparation raw medicinal material, adds relative to mixture quality 4～6 times
The ethanol that determining alcohol is 85～95%, be heated to reflux 1～3 hour, extract, filter obtain the first extracting solution, filter obtain
Medicinal residues add the ethanol that determining alcohol is 85～95% relative to medicinal residues quality 1～3 times, are heated to reflux 1～2 hour, extract,
Filtering and obtain the second extracting solution, the first extracting solution and the second extracting solution are merged, concentrating under reduced pressure removes alcohol solvent, is dried, obtains
Get dry extract；
Second step: the dry cream that the first step obtains is placed in super micron mill pulverizing 1～2 hour, pulverizes and sieves acquisition
The micropowders of 200～300 mesh；
3rd step: add relative to its quality 0.1～the microcrystalline cellulose of 0.3 times in the micropowders that second step obtains
Element, the lactose of 0.05～0.15 times, the starch of 0.1～0.3 times, sieve, mix homogeneously, pelletizes, and is dried, and adds relative to ultra micro
Fine powder quality 0.005～the magnesium stearate of 0.05 times, granulate, tabletting, make.
Present invention also offers the preparation method of above-mentioned Chinese medicine, the dosage form of described Chinese medicine is decoction, and its preparation method includes
Following steps:
The first step: the mixing of described raw medicinal material is put in purple casserole, adds clear water, to clear water dipped medical material upper surface 3
～5cm, soak 3～5 hours；
Second step: be placed on fire by purple casserole, after intense fire boils, uses slow fire instead and decocts the agent to medicinal liquid in 90～120 minutes slowly
Amount is 300～500ml, filters, obtains filtrate a, standby；
3rd step: residue medicinal residues are added clear water again, to clear water dipped medical material upper surface 3～5cm, soaks 2～3 little
Time；
4th step: be placed on fire by purple casserole, after intense fire boils, uses slow fire instead and decocts the 60～90 minutes dosage to medicinal liquid slowly
It is 200～400ml, filters, obtain filtrate b, filtrate a and filtrate b is mixed.
Beneficial effects of the present invention: Chinese medicine combined with chemotherapy of the present invention uses treatment damp and hot poison Sheng type cancer of pancreas, it is possible to effectively
Improve the therapeutical effect of chemotherapy, reduce the side effect of chemotherapy simultaneously；Epigastrium distension can be the most quickly mitigated or eliminated
Uncomfortable or distending pain, jaundice, tired, loss of appetite, become thin, suffer from diarrhoea or the symptom such as constipation, alleviate patient suffering, stablize the state of an illness, together
Time can extend the survival of patients phase.
Detailed description of the invention
The invention provides a kind of Chinese medicine treating damp and hot poison Sheng type cancer of pancreas, its raw medicinal material includes: Radix ardisiae brevicaulis,
Flexuose bittercress herb and seed, the grass that relieves internal heat, Herba Saussuseae Japonicae, concha Anodonta seu Cristaria grass, shoulder pole Artemisia, three-leaf tea, Radix Macropanacis Rosthornii, Herba Polygoni Capitati, Herba Hoyae Lyi, Radix craspedolobii schochii, Radix seu Folium Rubi Cochinchinensis,
Herba Polycarpaeae Corymbosae, Herba Odontitis Serotinae and Folium seu Semen Daphniphylli oldhami.
In described Chinese medicine, the pharmacology of each raw medicinal material is as follows:
Radix ardisiae brevicaulis: [source] is root or the herb of Myrsinacea plant Radix ardisiae brevicaulis.[nature and flavor] are pungent, micro-hardship, puckery,
Flat.[function cures mainly] expelling wind and clearing away heat, dissipating blood stasis for subsidence of swelling.Controlling laryngopharynx swelling and pain, acute toothache, rheumatism bones and muscles pain, lumbago, traumatic injury damages
Wound, innominate toxic swelling.
Flexuose bittercress herb and seed: [source] is crucifer Hairy Bittercress and the herb of bending Hairy Bittercress.[nature and flavor] are sweet, light, cool.
[function cures mainly] clearing away heat-damp and promoting diuresis, hemostasis of calming the nerves.Control damp-heat dysentery, pyretic stranguria, leucorrhea, cardiopalmus, have a sleepless night, toothache caused by fire of deficiency type, infantile malnutrition,
Spit blood, have blood in stool, furuncle.
Relieve internal heat grass: [source] is rhizome or the herb of Hemionitidaceae plant Er Yejinmao psilophyton.[nature and flavor] are bitter, cold.
[function cures mainly] detoxifies, dampness removing to stop itchin.Control pathogenic wind toxic skin infection, eczema, leukorrhagia.
Herba Saussuseae Japonicae: [source] is the herb of feverfew hieracioides.[nature and flavor] are pungent, bitter, flat.[function cures mainly] dispels the wind work
Blood.Dispelling the wind and dampness pathogens arthralgia pain, traumatic injury, leprosy.
Concha Anodonta seu Cristaria grass: [source] is the root of leguminous plant concha Anodonta seu Cristaria grass.[nature and flavor] micro-hardship, sweet, cool.[function cures mainly] is brought down a fever and is removed
Wet, disappear infantile malnutrition, cough-relieving.Control hyperpyrexia, flu, rheumatic arthritis, dysmenorrhea, infantile malnutrition, diarrhoea, dyspepsia, cough, roar
Breathe heavily, pertussis, jaundice.
Shoulder pole Artemisia: [source] is crucifer Fructus Arabidis pendulae and the fruit of the green Fructus Arabidis pendulae of powder.[nature and flavor] are pungent, flat.
[function cures mainly] heat-clearing and toxic substances removing, detumescence, control sore swollen toxin, vaginitis, trichomonas vaginitis.
Three-leaf tea: [source] is the Herb of sapindaceous plant ripple leaf Radix Allophylli Viridis.[nature and flavor] are sweet, light, flat.[function cures mainly]
Expelling wind and removing dampness, detoxify dissipating blood stasis.Main air pain of dampness syndrome, oedema due to nephritis, cirrhotic ascites, injury and bone fracture.
Radix Macropanacis Rosthornii: [source] is the root joined greatly of the short stalk of Araliaceae and leaf.[return through] sweet in the mouth, property is put down.[function cures mainly]
Expelling wind and removing dampness, disperse blood stasis and dredge collateral, spleen invigorating.Main air pain of dampness syndrome, traumatic injury wound is swollen, fracture, infantile malnutrition.
Herba Polygoni Capitati: [source] is the herb of polygonaceae plant Herba Polygoni Capitati.[nature and flavor] are bitter, pungent, cool in nature.[function cures mainly] heat clearing away profit
Wet, promoting blood circulation and stopping pain.Main dysentery, pyelonephritis, cystitis, lithangiuria, rheumatalgia, traumatic injury, mumps, skin infection, eczema.
Herba Hoyae Lyi: [source] is the stem and leaf of Yao Luo section plant fragrant flower Flos Cymbidii Ensifolii.[nature and flavor] acrid in the mouth, warm in nature.[return through] returns liver,
Spleen channel.[function cures mainly] expelling wind and removing dampness, promoting digestion and removing stagnation, promoting blood circulation to remove blood stasis.The strong pain of main foot, front is glutted, traumatic injury.
Radix craspedolobii schochii: [source] is the root of leguminous plant Fructus Crotonis rattan.[nature and flavor] are puckery, micro-hardship, temperature.[return through] GUIXIN warp.[function
Cure mainly] promoting blood circulation and hemostasis, expelling wind and removing dampness.Main visceral hemorrhage, menoxenia, metrorrhagia, leukorrhagia, rheumatic arthralgia, traumatic injury.
Radix seu Folium Rubi Cochinchinensis: [source] is the root of rosaceous plant Radix seu FoliumRubi Cochinchinensis.[nature and flavor] are bitter, pungent, temperature.[return through] returns liver, kidney channel.
[function cures mainly] expelling wind and removing dampness, promoting the circulation of QI to relieve pain.Main air pain of dampness syndrome, traumatic pain, lumbago and skelalgia.
Herba Polycarpaeae Corymbosae: [source] is the herb of pinkwort drum nail in vain.[nature and flavor] are light, cool in nature.[return through] returns bladder, stomach
Warp.[function cures mainly] heat-clearing and toxic substances removing, dampness removing, change long-pending.Main diarrhea due to summer heat and dampness, dysentery, urine leaching pain, ascites, infantile malnutrition, carbuncle swells
Poison.
Herba Odontitis Serotinae: [source] is the aerial parts of goatweed Herba Odontitis Serotinae.[nature and flavor] bitter in the mouth, cool in nature.[function cures mainly]
Clearing away heat-fire, promoting blood circulation and stopping pain.Main epidemic febrile disease is generated heat, and liver-fire is had a headache, hypochondriac pain, pain due to blood stasis.
Folium seu Semen Daphniphylli oldhami: [source] is the root of Daphniphyllaceae plant Folium seu Semen Daphniphylli oldhami, leaf.[nature and flavor] are bitter, puckery, cool.[return through] GUIXIN,
Liver, kidney channel.[function cures mainly] heat-clearing and toxic substances removing, promoting blood circulation to remove blood stasis.Main cold, fever, laryngopharynx swelling and pain, spleen enlargement, venom, bone
Folding wound.
The ratio of weight and number of each raw medicinal material of described Chinese medicine can be preferably as follows: Radix ardisiae brevicaulis 10～20 parts, flexuose bittercress herb and seed
40～50 parts, relieve internal heat grass 5～15 parts, Herba Saussuseae Japonicae 15～25 parts, concha Anodonta seu Cristaria grass 55～65 parts, shoulder pole Artemisia 25～35 parts, three-leaf tea 15
～25 parts, Radix Macropanacis Rosthornii 5～15 parts, Herba Polygoni Capitati 40～50 parts, Herba Hoyae Lyi 5～15 parts, Radix craspedolobii schochii 55～65 parts, Radix seu Folium Rubi Cochinchinensis 10～20
Part, Herba Polycarpaeae Corymbosae 15～25 parts, Herba Odontitis Serotinae 10～20 parts and Folium seu Semen Daphniphylli oldhami 25～35 parts.
The ratio of weight and number of each raw medicinal material of described Chinese medicine can be preferably as follows: Radix ardisiae brevicaulis 10～15 parts, flexuose bittercress herb and seed
40～45 parts, relieve internal heat grass 5～10 parts, Herba Saussuseae Japonicae 15～20 parts, concha Anodonta seu Cristaria grass 55～60 parts, shoulder pole Artemisia 25～30 parts, three-leaf tea 15
～20 parts, Radix Macropanacis Rosthornii 5～10 parts, Herba Polygoni Capitati 40～45 parts, Herba Hoyae Lyi 5～10 parts, Radix craspedolobii schochii 55～60 parts, Radix seu Folium Rubi Cochinchinensis 10～15
Part, Herba Polycarpaeae Corymbosae 15～20 parts, Herba Odontitis Serotinae 10～15 parts and Folium seu Semen Daphniphylli oldhami 25～30 parts.
The ratio of weight and number of each raw medicinal material of described Chinese medicine can be preferably as follows: Radix ardisiae brevicaulis 11 parts, flexuose bittercress herb and seed 42 parts,
Relieve internal heat grass 6 parts, Herba Saussuseae Japonicae 18 parts, concha Anodonta seu Cristaria grass 59 parts, shoulder pole Artemisia 27 parts, three-leaf tea 16 parts, Radix Macropanacis Rosthornii 8 parts, Herba Polygoni Capitati 44 parts, stone
7 parts of straw sandals, 56 parts of Radix craspedolobii schochii, Radix seu Folium Rubi Cochinchinensis 10 parts, Herba Polycarpaeae Corymbosae 20 parts, Herba Odontitis Serotinae 13 parts and Folium seu Semen Daphniphylli oldhami 29 parts.
Present invention also offers the preparation method of above-mentioned Chinese medicine, the dosage form of described Chinese medicine is tablet, and its preparation method includes
Following steps:
The first step: be mixed in proportion by each for described Chinese medicine preparation raw medicinal material, adds relative to mixture quality 4～6 times
The ethanol that determining alcohol is 85～95%, be heated to reflux 1～3 hour, extract, filter obtain the first extracting solution, filter obtain
Medicinal residues add the ethanol that determining alcohol is 85～95% relative to medicinal residues quality 1～3 times, are heated to reflux 1～2 hour, extract,
Filtering and obtain the second extracting solution, the first extracting solution and the second extracting solution are merged, concentrating under reduced pressure removes alcohol solvent, is dried, obtains
Get dry extract；
Second step: the dry cream that the first step obtains is placed in super micron mill pulverizing 1～2 hour, pulverizes and sieves acquisition
The micropowders of 200～300 mesh；
3rd step: add relative to its quality 0.1～the microcrystalline cellulose of 0.3 times in the micropowders that second step obtains
Element, the lactose of 0.05～0.15 times, the starch of 0.1～0.3 times, sieve, mix homogeneously, pelletizes, and is dried, and adds relative to ultra micro
Fine powder quality 0.005～the magnesium stearate of 0.05 times, granulate, tabletting, make.
Present invention also offers the preparation method of above-mentioned Chinese medicine, the dosage form of described Chinese medicine is decoction, and its preparation method includes
Following steps:
The first step: the mixing of described raw medicinal material is put in purple casserole, adds clear water, to clear water dipped medical material upper surface 3
～5cm, soak 3～5 hours；
Second step: be placed on fire by purple casserole, after intense fire boils, uses slow fire instead and decocts the agent to medicinal liquid in 90～120 minutes slowly
Amount is 300～500ml, filters, obtains filtrate a, standby；
3rd step: residue medicinal residues are added clear water again, to clear water dipped medical material upper surface 3～5cm, soaks 2～3 little
Time；
4th step: be placed on fire by purple casserole, after intense fire boils, uses slow fire instead and decocts the 60～90 minutes dosage to medicinal liquid slowly
It is 200～400ml, filters, obtain filtrate b, filtrate a and filtrate b is mixed.
Hereinafter use embodiment to describe embodiments of the present invention in detail, fully understand how the present invention applies skill whereby
Art means solve technical problem, reach technique effect and implement according to this.
Embodiment 1: tablet
Take Radix ardisiae brevicaulis 110g, flexuose bittercress herb and seed 420g, relieve internal heat grass 60g, Herba Saussuseae Japonicae 180g, concha Anodonta seu Cristaria grass 590g, shoulder pole Artemisia
270g, three-leaf tea 160g, Radix Macropanacis Rosthornii 80g, Herba Polygoni Capitati 440g, Herba Hoyae Lyi 70g, Radix craspedolobii schochii 560g, Radix seu Folium Rubi Cochinchinensis 100g, Herba Polycarpaeae Corymbosae
200g, Herba Odontitis Serotinae 130g and Folium seu Semen Daphniphylli oldhami 290g；
Its preparation method comprises the following steps:
The first step: be mixed in proportion by each for described Chinese medicine preparation raw medicinal material, adds the alcohol relative to mixture quality 4 times
Concentration is the ethanol of 95%, is heated to reflux 3 hours, extracts, and filters and obtains the first extracting solution, filters the medicinal residues obtained and adds phase
For the ethanol that determining alcohol is 85% of medicinal residues quality 3 times, it is heated to reflux 2 hours, extracts, filter and obtain the second extracting solution, will
First extracting solution and the second extracting solution merge, and concentrating under reduced pressure removes alcohol solvent, are dried, it is thus achieved that dry cream；
Second step: the dry cream that the first step obtains is placed in super micron mill pulverizing 2 hours, pulverizes and sieves acquisition 200
Purpose micropowders；
3rd step: second step obtain micropowders in add the microcrystalline Cellulose relative to its quality 0.3 times, 0.1
Times lactose, the starch of 0.3 times, sieve, mix homogeneously, pelletize, be dried, add hard relative to micropowders quality 0.02 times
Fatty acid magnesium, granulate, tabletting, make.
Embodiment 2: decoction
Take Radix ardisiae brevicaulis 130g, flexuose bittercress herb and seed 430g, relieve internal heat grass 90g, Herba Saussuseae Japonicae 150g, concha Anodonta seu Cristaria grass 570g, shoulder pole Artemisia
280g, three-leaf tea 190g, Radix Macropanacis Rosthornii 50g, Herba Polygoni Capitati 410g, Herba Hoyae Lyi 90g, Radix craspedolobii schochii 580g, Radix seu Folium Rubi Cochinchinensis 130g, Herba Polycarpaeae Corymbosae
160g, Herba Odontitis Serotinae 150g and Folium seu Semen Daphniphylli oldhami 260g；
Its preparation method comprises the following steps:
The first step: the mixing of described raw medicinal material is put in purple casserole, adds clear water, to clear water dipped medical material upper surface
3cm, soaks 3 hours；
Second step: be placed on fire by purple casserole, after intense fire boils, uses slow fire instead and decocts the 120 minutes dosage to medicinal liquid slowly and be
400ml, filters, obtains filtrate a, standby；
3rd step: residue medicinal residues are added clear water again, to clear water dipped medical material upper surface 3cm, soaks 2 hours；
4th step: be placed on fire by purple casserole, after intense fire boils, uses slow fire instead and decocts the 60 minutes dosage to medicinal liquid slowly and be
200ml, filters, obtains filtrate b, mixed by filtrate a and filtrate b.
Toxicity test:
Acute toxicity testing: application mice 70, male and female half and half, body weight 18～26g, carries out acute toxicity test.Mice
It is randomly divided into two groups, i.e. matched group and administration group, fasting 12 hours, the Chinese medicine tablet prepared by embodiments of the invention 1 before experiment
Agent is dissolved in water, and (concentration is 8.46g crude drug/ml, maximum concentration) gavage, gavage volume is 5ml/kg (i.e. single-dose agent
Amount is 42.3 crude drugs/kg), matched group gives normal saline, within one day, is administered 2 times, and delivery time 6 hours, after administration
Continuous Observation 14 days, and record toxic reaction and the death toll of mice.Test result indicate that: compare with matched group, little after administration
Mus has no notable difference, and experiment Continuous Observation 14 days, mouse systemic situation, diet, drinking-water, body weight increase the most normal.Mice mouth
Taking the tablet LD50 > 42.3 crude drugs/kg of the gavage present invention, every day, maximum dosage-feeding was 84.6 crude drugs/kg/ day.In the present invention
Medicine clinical application amount is 7.8g crude drug/day/people, and adult's body weight is in terms of 60KG, and average dosage is 0.13g crude drug/kg/ day.
By weighing machine: as quantity 651 times of the dosis tolerata of the Chinese medicine of mice (average weight is in terms of 22g) the oral administration gavage present invention.
Therefore the Chinese medicine acute toxicity of the present invention is extremely low, clinical drug safety.
Long term toxicity test: three groups of mices (often group 20) are pressed 15.26,22.47 and by Chinese medicine embodiment 1 tablet of the present invention
After 38.36g crude drug/kg continuous use 15 weeks (1.0ml/100g body weight, every day 2 times) and drug withdrawal 4 weeks, result shows: the present invention
Chinese medicine is to equal nothings of index such as the hair of mice, behavior, defecation, body weight, organ weights, hemogram, hepatic and renal function, blood glucose, blood fat
Significantly affecting, internal organs naked eyes do not find that difference change and histological indications show, after medication 15 weeks and drug withdrawal 4 weeks, little
The each internal organs of Mus are all without substantially changing.Illustrate that Chinese medicine of the present invention is little to toxicity after mice long-term prescription, after drug withdrawal, also do not have difference anti-
Should, application safety.
Clinical data:
Case selection: whole 166 example cases are my Out-patient Department or inpatient, all patient radiation treat front all through disease
Confirmation of science, and all have x-ray to take the photograph sheet, CT scan or nuclear magnetic resonance check for clinical TNM by stages, all do by clinical criteria before chemotherapy
Checking before chemotherapy and confirm without chemicotherapy contraindication, all patients are all without transfer cancer of pancreas (M0).Be randomly divided into chemotherapy group and in
Medicine adds chemotherapy group, wherein, chemotherapy group 80 example, male 52 example, women 28 example, age 44～75 years old；I phase 15 example, II phase 37 example, III
Phase 28 example.Chinese medicine adds chemotherapy group 86 example, male 56 example, women 30 example, age 45～77 years old；I phase 16 example, II phase 40 example, III phase
30 examples.Two groups of sexes, age, clinical stages and the equal not statistically significant of coincident with severity degree of condition comparing difference (p > 0.05).
Diagnostic criteria:
Western medicine diagnose standard: " clinical disease diagnosis and the curative effect judging standard " the 8th write according to hospital associate of Hunan Province
The diagnostic criteria of cancer of pancreas in Section three of 13 chapters.
Clinical stages standard: " clinical disease diagnosis and the curative effect judging standard " the 8th write according to hospital associate of Hunan Province
The clinical stages standard of the TNM (1997) by stages of the UICC of cancer of pancreas in Section three of 13 chapters.
Syndrome Differentiation of Traditional Chinese Medicine standard: damp and hot poison Sheng type: heating, xerostomia excessive thirst, upper abdomen distension, the lower twinge of the side of body, deep pressure can be touched
And lump, nausea and vomiting, whole body turns to be yellow, and color depth is dark, even dirty-green, constipation with dry stool, and color is white, oliguria with reddish urine, red tongue, tongue
Yellow greasy few Tianjin, wiry and frequent pulse.
Therapeutic Method
Chemotherapy group: chemotherapeutics selects cisplatin (CDDP) 30mg/M2D1-3, gemzar 1000mg/M2D1,8,15, fluorouracil
(5-Fu)500mg/M2D1-5, selects 2 kinds or 3 kinds of drug combinations, intravenously administrable therein during chemotherapy；It within 28 days, it is a cycle.
Chinese medicine adds chemotherapy group: on the basis of chemotherapy group is treated, oral Chinese medicine embodiment 1 tablet of the present invention, three times a day,
Each 4；It within 28 days, it is a cycle.
Evaluation criteria: according to WHO treatment malignant tumor evaluation criteria evaluation curative effect.Complete incidence graph (CR): all visible diseases
Become and be wholly absent at least 4 weeks；Part alleviates (PR): tumor size is estimated to reduce >=50% at least 4 week；Unchanged (NC): without bright
Aobvious change at least 4 week, stable including pathological changes, tumor size is estimated to expand less than 25%, reduces less than 50%；Pathological changes extends
(PD): new focus occurs or original pathological changes is estimated to expand > 25%；4 ranking pancreas portion's primary tumors and Metastatic Lymph Nodes
Gross tumor volume changes.
Statistical method: meet rank test, paired t-test and independence with statistical package SPSS1010Wi leoxon
Sample t-test.
Result of the test: according to above-mentioned WHO evaluation criteria, 4 all after dates of drug treatment, carry out short term effect effect system respectively
Meter, the results are shown in Table 1.
Table 1: each group short term effect tracking table record
| Group | CR | PR | NC | PD | Effective percentage (%) |
| Chemotherapy group | 4 | 23 | 35 | 18 | 27 (33.75%) |
| Chinese medicine adds chemotherapy group | 14 | 46 | 17 | 9 | 60(69.77) |
By table 1, Chinese medicine adds chemotherapy group curative effect and is better than chemotherapy group, and two groups of Different therapeutical effects are statistically significant.And it is logical
Cross clinical observation, patient's patient's condition inquiry every day is summed up and regularly x-ray, CT or ultrasound diagnosis etc., determines the Chinese medicine system of the present invention
Agent (most 1-2 month) can quickly be mitigated or eliminated epigastrium distension discomfort or distending pain, jaundice, tired, appetite in a short time
Go down, become thin, suffer from diarrhoea or the symptom such as constipation, alleviate patient suffering, stablize the state of an illness；The treatment effect of chemotherapy can also be increased simultaneously
Really, and reduce chemotherapy side effect.
All patients are carried out long-term follow record, and adds up survival number respectively and deposit when 1 year, 2 years, 3 years and 5 years
Motility rate, concrete data are shown in Table 2.
Table 2: each group long-term survival rate follows the tracks of survival number and survival rate
| Group | 1 year | 2 years | 3 years | 5 years |
| Chemotherapy group | 17 (21.25%) | 8 (10%) | 2 (2.5%) | 1 (1.25%) |
| Chinese medicine adds chemotherapy group | 45 (52.33%) | 30 (34.88%) | 17 (19.77%) | 9 (10.47%) |
By table 2, Chinese medicine adds chemotherapy group compared with chemotherapy group, can significantly improve life span, and two groups of differences have system
Meaning learned by meter.
Concrete case: high certain, male, 57 years old, because of stomachache, jaundice with become thin to be admitted to hospital and see a doctor, through imaging examination and pathology
Property inspection etc. be diagnosed as cancer of pancreas (III phase), according to tcm symptom, heating, xerostomia excessive thirst, upper abdomen distension, the lower twinge of the side of body, deeply press
Accessible lump, nausea and vomiting, whole body turns to be yellow, and color depth is dark, constipation with dry stool, and color is white, oliguria with reddish urine, red tongue, the few Tianjin of yellow and greasy fur,
Wiry and frequent pulse, further typing is damp and hot poison Sheng type cancer of pancreas, gives operative treatment, gives chemotherapy 3 cycles, give simultaneously after treatment
Giving Chinese medicine embodiment 1 tablet of the present invention, treatment end reaches complete incidence graph standard.There is not obvious epigastrium distension not in chemotherapy process
Suitable or distending pain, jaundice, tired, loss of appetite, become thin, suffer from diarrhoea or the symptom such as constipation.Continue to take Chinese medicine after treatment and consolidate half a year,
Survive 3 years 5 months.
The above, be only presently preferred embodiments of the present invention, is not the restriction that the present invention makees other form, appoints
What those skilled in the art changed possibly also with the technology contents of the disclosure above or be modified as equivalent variations etc.
Effect embodiment.But every without departing from technical solution of the present invention content, the technical spirit of the foundation present invention is to above example institute
Any simple modification, equivalent variations and the remodeling made, still falls within the protection domain of technical solution of the present invention.
Claims (8)
1. the Chinese medicine treating damp and hot poison Sheng type cancer of pancreas, it is characterised in that each raw medicinal material of described Chinese medicine includes: short stem Zhu
Sand root, flexuose bittercress herb and seed, the grass that relieves internal heat, Herba Saussuseae Japonicae, concha Anodonta seu Cristaria grass, shoulder pole Artemisia, three-leaf tea, Radix Macropanacis Rosthornii, Herba Polygoni Capitati, Herba Hoyae Lyi, Radix craspedolobii schochii, five
Leaf bubble, Herba Polycarpaeae Corymbosae, Herba Odontitis Serotinae and Folium seu Semen Daphniphylli oldhami.
2. Chinese medicine as claimed in claim 1, it is characterised in that the ratio of weight and number of each raw medicinal material of described Chinese medicine is as follows: short
Stem Radix Ardisiae Crenatae 10～20 parts, flexuose bittercress herb and seed 40～50 parts, the grass 5～15 parts that relieves internal heat, Herba Saussuseae Japonicae 15～25 parts, concha Anodonta seu Cristaria grass 55～65 parts,
Shoulder pole Artemisia 25～35 parts, three-leaf tea 15～25 parts, Radix Macropanacis Rosthornii 5～15 parts, Herba Polygoni Capitati 40～50 parts, Herba Hoyae Lyi 5～15 parts, ferrum rattan
Root 55～65 parts, Radix seu Folium Rubi Cochinchinensis 10～20 parts, Herba Polycarpaeae Corymbosae 15～25 parts, Herba Odontitis Serotinae 10～20 parts and Folium seu Semen Daphniphylli oldhami 25～35 parts.
3. Chinese medicine as claimed in claim 1 or 2, it is characterised in that the ratio of weight and number of each raw medicinal material of described Chinese medicine is as follows:
Radix ardisiae brevicaulis 10～15 parts, flexuose bittercress herb and seed 40～45 parts, relieve internal heat grass 5～10 parts, Herba Saussuseae Japonicae 15～20 parts, concha Anodonta seu Cristaria grass 55～60
Part, shoulder pole Artemisia 25～30 parts, three-leaf tea 15～20 parts, Radix Macropanacis Rosthornii 5～10 parts, Herba Polygoni Capitati 40～45 parts, Herba Hoyae Lyi 5～10 parts,
Radix craspedolobii schochii 55～60 parts, Radix seu Folium Rubi Cochinchinensis 10～15 parts, Herba Polycarpaeae Corymbosae 15～20 parts, Herba Odontitis Serotinae 10～15 parts and Folium seu Semen Daphniphylli oldhami 25～30 parts.
4. the Chinese medicine as described in claims 1 to 3, it is characterised in that the ratio of weight and number of each raw medicinal material of described Chinese medicine is as follows:
Radix ardisiae brevicaulis 11 parts, flexuose bittercress herb and seed 42 parts, the grass 6 parts that relieves internal heat, Herba Saussuseae Japonicae 18 parts, concha Anodonta seu Cristaria grass 59 parts, shoulder pole Artemisia 27 parts, three-leaf tea 16
Part, Radix Macropanacis Rosthornii 8 parts, Herba Polygoni Capitati 44 parts, Herba Hoyae Lyi 7 parts, 56 parts of Radix craspedolobii schochii, Radix seu Folium Rubi Cochinchinensis 10 parts, Herba Polycarpaeae Corymbosae 20 parts, Herba Odontitis Serotinae 13 parts
With Folium seu Semen Daphniphylli oldhami 29 parts.
5. the Chinese medicine as described in Claims 1-4, it is characterised in that the dosage form of described Chinese medicine is tablet, and its preparation method includes
Following steps:
The first step: be mixed in proportion by each for described Chinese medicine preparation raw medicinal material, adds relative to mixture quality 4～the alcohol of 6 times
Concentration is the ethanol of 85～95%, is heated to reflux 1～3 hour, extracts, and filters and obtains the first extracting solution, filters the medicinal residues obtained
Add the ethanol that determining alcohol is 85～95% relative to medicinal residues quality 1～3 times, be heated to reflux 1～2 hour, extract, filter
Obtaining the second extracting solution, the first extracting solution and the second extracting solution are merged, concentrating under reduced pressure removes alcohol solvent, is dried, it is thus achieved that dry
Cream；
Second step: by the first step obtain dry cream be placed in super micron mill pulverizing 1～2 hour, pulverize and sieve acquisition 200～
The micropowders of 300 mesh；
3rd step: add in the micropowders that second step obtains relative to its quality 0.1～the microcrystalline Cellulose of 0.3 times,
The lactose of 0.05～0.15 times, the starch of 0.1～0.3 times, sieve, mix homogeneously, pelletizes, and is dried, and adds relative to ultra tiny
Opaque amount 0.005～the magnesium stearate of 0.05 times, granulate, tabletting, make.
6. the Chinese medicine as described in Claims 1-4, it is characterised in that the dosage form of described Chinese medicine is decoction, and its preparation method includes
Following steps:
The first step: the mixing of described raw medicinal material is put in purple casserole, adds clear water, to clear water dipped medical material upper surface 3～
5cm, soaks 3～5 hours；
Second step: be placed on fire by purple casserole, after intense fire boils, uses slow fire instead and decocts the 90～120 minutes dosage to medicinal liquid slowly and be
300～500ml, filter, obtain filtrate a, standby；
3rd step: residue medicinal residues are added clear water again, to clear water dipped medical material upper surface 3～5cm, soaks 2～3 hours；
4th step: be placed on fire by purple casserole, after intense fire boils, uses slow fire instead and decocts the 60～90 minutes dosage to medicinal liquid slowly and be
200～400ml, filter, obtain filtrate b, filtrate a and filtrate b is mixed.
7. the preparation method of Chinese medicine described in a Claims 1-4, it is characterised in that the dosage form of described Chinese medicine is tablet, its system
Preparation Method comprises the following steps:
The first step: be mixed in proportion by each for described Chinese medicine preparation raw medicinal material, adds relative to mixture quality 4～the alcohol of 6 times
Concentration is the ethanol of 85～95%, is heated to reflux 1～3 hour, extracts, and filters and obtains the first extracting solution, filters the medicinal residues obtained
Add the ethanol that determining alcohol is 85～95% relative to medicinal residues quality 1～3 times, be heated to reflux 1～2 hour, extract, filter
Obtaining the second extracting solution, the first extracting solution and the second extracting solution are merged, concentrating under reduced pressure removes alcohol solvent, is dried, it is thus achieved that dry
Cream；
Second step: by the first step obtain dry cream be placed in super micron mill pulverizing 1～2 hour, pulverize and sieve acquisition 200～
The micropowders of 300 mesh；
3rd step: add in the micropowders that second step obtains relative to its quality 0.1～the microcrystalline Cellulose of 0.3 times,
The lactose of 0.05～0.15 times, the starch of 0.1～0.3 times, sieve, mix homogeneously, pelletizes, and is dried, and adds relative to ultra tiny
Opaque amount 0.005～the magnesium stearate of 0.05 times, granulate, tabletting, make.
8. the preparation method of Chinese medicine described in a Claims 1-4, it is characterised in that the dosage form of described Chinese medicine is decoction, its system
Preparation Method comprises the following steps:
The first step: the mixing of described raw medicinal material is put in purple casserole, adds clear water, to clear water dipped medical material upper surface 3～
5cm, soaks 3～5 hours；
Second step: be placed on fire by purple casserole, after intense fire boils, uses slow fire instead and decocts the 90～120 minutes dosage to medicinal liquid slowly and be
300～500ml, filter, obtain filtrate a, standby；
3rd step: residue medicinal residues are added clear water again, to clear water dipped medical material upper surface 3～5cm, soaks 2～3 hours；
4th step: be placed on fire by purple casserole, after intense fire boils, uses slow fire instead and decocts the 60～90 minutes dosage to medicinal liquid slowly and be
200～400ml, filter, obtain filtrate b, filtrate a and filtrate b is mixed.
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| CN103386024A (en) * | 2013-06-19 | 2013-11-13 | 孙伟 | Traditional Chinese medicine preparation for treating pancreas cancer and preparation method thereof |
| CN104958474A (en) * | 2015-07-01 | 2015-10-07 | 张晓艳 | Traditional Chinese medicine for treating damp heat stagnation type pancreatic cancer and preparation method thereof |
| CN105641438A (en) * | 2016-01-19 | 2016-06-08 | 王向丽 | Traditional Chinese medicine for treating intestinal collateral blood stasis type ulcerative colitis and preparation method |
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|---|---|---|---|---|
| CN1495847A (en) * | 2002-09-20 | 2004-05-12 | ��ʽ����Һ���ȶ˼����������� | Crystallizing device, crystallizing method and used phase-shift mask and filter |
| CN103386024A (en) * | 2013-06-19 | 2013-11-13 | 孙伟 | Traditional Chinese medicine preparation for treating pancreas cancer and preparation method thereof |
| CN104958474A (en) * | 2015-07-01 | 2015-10-07 | 张晓艳 | Traditional Chinese medicine for treating damp heat stagnation type pancreatic cancer and preparation method thereof |
| CN105641438A (en) * | 2016-01-19 | 2016-06-08 | 王向丽 | Traditional Chinese medicine for treating intestinal collateral blood stasis type ulcerative colitis and preparation method |
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