CN106074671A - U.S. rattan fruit leaf extract application in preparing hypoglycemic drug - Google Patents
U.S. rattan fruit leaf extract application in preparing hypoglycemic drug Download PDFInfo
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- CN106074671A CN106074671A CN201610618692.5A CN201610618692A CN106074671A CN 106074671 A CN106074671 A CN 106074671A CN 201610618692 A CN201610618692 A CN 201610618692A CN 106074671 A CN106074671 A CN 106074671A
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- rattan fruit
- fruit leaf
- leaf extract
- rattan
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- 241000345998 Calamus manan Species 0.000 title claims abstract description 44
- 235000013399 edible fruits Nutrition 0.000 title claims abstract description 44
- 235000012950 rattan cane Nutrition 0.000 title claims abstract description 44
- 239000000284 extract Substances 0.000 title claims abstract description 28
- 239000003472 antidiabetic agent Substances 0.000 title claims abstract description 7
- 238000000034 method Methods 0.000 claims abstract description 11
- 239000002904 solvent Substances 0.000 claims abstract description 11
- 239000012141 concentrate Substances 0.000 claims abstract description 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 11
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 10
- 239000000203 mixture Substances 0.000 claims description 2
- 238000000638 solvent extraction Methods 0.000 claims description 2
- 238000000605 extraction Methods 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 239000008280 blood Substances 0.000 abstract description 17
- 210000004369 blood Anatomy 0.000 abstract description 17
- 230000000694 effects Effects 0.000 abstract description 16
- 235000000346 sugar Nutrition 0.000 abstract description 10
- 230000002218 hypoglycaemic effect Effects 0.000 abstract description 9
- 206010012601 diabetes mellitus Diseases 0.000 abstract description 8
- 239000003814 drug Substances 0.000 abstract description 6
- 239000000419 plant extract Substances 0.000 abstract description 4
- 231100000331 toxic Toxicity 0.000 abstract description 2
- 230000002588 toxic effect Effects 0.000 abstract description 2
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 9
- 239000008103 glucose Substances 0.000 description 9
- 241000699670 Mus sp. Species 0.000 description 8
- 241000699666 Mus <mouse, genus> Species 0.000 description 4
- 239000000706 filtrate Substances 0.000 description 3
- 229960004580 glibenclamide Drugs 0.000 description 3
- 235000001727 glucose Nutrition 0.000 description 3
- ZNNLBTZKUZBEKO-UHFFFAOYSA-N glyburide Chemical compound COC1=CC=C(Cl)C=C1C(=O)NCCC1=CC=C(S(=O)(=O)NC(=O)NC2CCCCC2)C=C1 ZNNLBTZKUZBEKO-UHFFFAOYSA-N 0.000 description 3
- 208000013016 Hypoglycemia Diseases 0.000 description 2
- 230000003247 decreasing effect Effects 0.000 description 2
- 238000002474 experimental method Methods 0.000 description 2
- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 description 2
- 235000012054 meals Nutrition 0.000 description 2
- 230000003285 pharmacodynamic effect Effects 0.000 description 2
- 239000000047 product Substances 0.000 description 2
- 208000024891 symptom Diseases 0.000 description 2
- 229940123208 Biguanide Drugs 0.000 description 1
- 241000221017 Euphorbiaceae Species 0.000 description 1
- 229940122069 Glycosidase inhibitor Drugs 0.000 description 1
- 206010018473 Glycosuria Diseases 0.000 description 1
- 102000004877 Insulin Human genes 0.000 description 1
- 108090001061 Insulin Proteins 0.000 description 1
- 208000008589 Obesity Diseases 0.000 description 1
- 241001300674 Plukenetia volubilis Species 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 229940127003 anti-diabetic drug Drugs 0.000 description 1
- 150000004283 biguanides Chemical class 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 208000002173 dizziness Diseases 0.000 description 1
- 230000007613 environmental effect Effects 0.000 description 1
- 235000013305 food Nutrition 0.000 description 1
- 238000004108 freeze drying Methods 0.000 description 1
- 230000006870 function Effects 0.000 description 1
- 230000002068 genetic effect Effects 0.000 description 1
- 210000004907 gland Anatomy 0.000 description 1
- 150000002304 glucoses Chemical class 0.000 description 1
- 239000003316 glycosidase inhibitor Substances 0.000 description 1
- 230000003054 hormonal effect Effects 0.000 description 1
- 230000003345 hyperglycaemic effect Effects 0.000 description 1
- 201000001421 hyperglycemia Diseases 0.000 description 1
- 229940125396 insulin Drugs 0.000 description 1
- 230000001788 irregular Effects 0.000 description 1
- 210000004185 liver Anatomy 0.000 description 1
- 235000020824 obesity Nutrition 0.000 description 1
- 210000000496 pancreas Anatomy 0.000 description 1
- 239000013641 positive control Substances 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 230000005180 public health Effects 0.000 description 1
- 230000009711 regulatory function Effects 0.000 description 1
- 230000035945 sensitivity Effects 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 230000007704 transition Effects 0.000 description 1
- 238000002137 ultrasound extraction Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/47—Euphorbiaceae (Spurge family), e.g. Ricinus (castorbean)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation or decoction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
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- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Alternative & Traditional Medicine (AREA)
- Biotechnology (AREA)
- Botany (AREA)
- Medical Informatics (AREA)
- Medicinal Chemistry (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicines Containing Plant Substances (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
Abstract
The invention discloses U.S. rattan fruit leaf extract application in preparing hypoglycemic drug.The extracting method of U.S. rattan fruit leaf extract comprises the steps: to take U.S. rattan fruit leaf, and addition solvent decocts and extracts, filter extracting solution, concentrates.U.S. rattan fruit leaf efficacy effect is focused by the present invention, uses natural plant extracts, it is to avoid the Western medicine toxic and side effects to human body.Extracting method is simple, and mode is flexible.U.S. rattan fruit leaf extract belongs to plant extract, and stable effect is gentle, does not finds obvious toxic-side effects temporarily, avoids the drawback of tradition Western medicine aggravation diabetes sequela while playing hypoglycemic activity.Carrying out mouse test with U.S. rattan fruit leaf extract, the U.S. rattan fruit leaf extract of result of study display 50mg/kg.BW dosage group i.e. has the effect significantly reducing blood sugar for human body level, thus it is speculated that containing hypoglycemic functional component in U.S. rattan fruit leaf.
Description
Technical field
The present invention relates to U.S. rattan fruit leaf, specifically, relate to U.S. rattan fruit leaf extract in preparing hypoglycemic drug
Application.
Background technology
U.S. rattan fruit, belongs to Euphorbiaceae U.S. rattan fruit and belongs to, for perennial bejuco, 2006 after South America introduces China
The ground plantations such as Hainan, Yunnan, Guangxi, 2013, China's Ministry of Public Health approval oil and fat of sacha inchi was new resource food.U.S. rattan fruit leaf is
Papery alternate leaf, the most avette or wealthy heart, long 9-15 cm, wide 6-10 cm；Top is tapering or short-tail is sharp, and base portion is the most truncated, limit
Edge tool knuckle-tooth or irregular sawtooth, have body of gland.Have no the report about U.S. rattan fruit leaf extract at present.
Fasting glucose normal value is at below 6.1mmol/L, and the normal value of two hours blood glucoses is at below 7.8mmol/L after the meal,
If above this scope, referred to as hyperglycemia.Under normal circumstances, human body can this two adjusts greatly by hormonal regulation and neuroregulation
Joint system guarantees that the source of blood glucose keeps balance with outlet, makes blood glucose maintain certain level.But at inherited genetic factors (such as glycosuria
Sick family history) with under the common effect of environmental factors (such as irrational meals, obesity etc.), two big regulatory functions get muddled,
Arise that blood sugar level raises.Western medicine such as sulphanylureas, biguanides, insulin, glycosidase inhibitor, Main Function is to stimulate pancreas
Island element is secreted, improves human body sensitivity, is slowed down sugar transition and absorption；But Western medicine the most all can have side effect, modal pair
Effect is hypoglycemia and the damage to liver.Frequently hypoglycemia can cause hypomnesis, dizziness, unable, old and feeble, consequence is the tightest
Weight is the biggest to damage to patient.
Summary of the invention
It is an object of the invention to overcome the deficiencies in the prior art, it is provided that U.S. rattan fruit leaf extract is preparing hypoglycemic drug
In application.
To achieve these goals, the present invention adopts the following technical scheme that
Present invention discover that U.S. rattan fruit leaf extract has significant effect of lowering blood sugar.
The extracting method of above-mentioned U.S. rattan fruit leaf extract comprises the steps: to take U.S. rattan fruit leaf, adds solvent and decocts
Extract, filter extracting solution, concentrate.
As preferably, in said extracted method, described solvent is water or ethanol or its mixture.
As preferably, in said extracted method, the consumption of described solvent is 1-40 times of U.S. rattan fruit foliage weight.
As preferably, in said extracted method, the consumption of described solvent is 8-20 times of U.S. rattan fruit foliage weight.
As preferably, in said extracted method, the consumption of described solvent is 10-15 times of U.S. rattan fruit foliage weight.
As preferably, in said extracted method, the number of times of described solvent extraction is 1-3 time, each 0.2-6 hour.
As preferably, in said extracted method, when described concentration refers to be concentrated into 25 DEG C relative density be 1.1～
1.3。
Compared with prior art, there is advantages that U.S. rattan fruit leaf efficacy effect is carried out by the present invention
Focus on, use natural plant extracts, it is to avoid the Western medicine toxic and side effects to human body.Extracting method is simple, and mode is flexible.Beautiful
Rattan fruit leaf extract belongs to plant extract, and stable effect is gentle, does not finds obvious toxic-side effects temporarily, plays hypoglycemic activity
While avoid tradition Western medicine aggravation diabetes sequela drawback.Mouse test is carried out, research with U.S. rattan fruit leaf extract
Result display 50mg/kg.BW dosage group U.S. rattan fruit leaf extract i.e. have significantly reduce blood sugar for human body level effect (
Notable blood sugar decreasing effect can be presented in 1-3h), thus it is speculated that containing hypoglycemic functional component in U.S. rattan fruit leaf.
Accompanying drawing explanation
Fig. 1 is that U.S. rattan fruit leaf water extract affects figure to blood glucose in diabetic mice level.
Detailed description of the invention
In order to be more clearly understood that the technology contents of the present invention, describe in detail especially exemplified by following example, but the present invention
Embodiment be not limited to this.
Embodiment 1: U.S. rattan fruit leaf water extract
Take U.S. rattan fruit leaf dry product 10Kg, wash, add 10 times of weight water, soak 1 hour, heated and boiled 3 hours, mistake
Filter, when concentrating the filtrate to 20 DEG C, relative density reaches 1.3, and concentrated solution is spray-dried, and obtains dry fine powder 1.25Kg.
Embodiment 2: U.S. rattan fruit leaf combination (water+ethanol) extract
Take U.S. rattan fruit leaf dry product 10Kg, wash, add 8 times of weight water, soak 1 hour, heated and boiled 3 hours, mistake
Filter, when concentrating the filtrate to 20 DEG C, relative density reaches 1.2, concentrated solution 8 times of weight 80% ethanol ultrasonic extraction 2 hours, mistake
Filter, merging filtrate, lyophilization obtains dried object 0.65Kg.
The pharmacodynamic experiment of embodiment 3. embodiment 1
Diabetic mice is tested, and investigates the blood sugar decreasing effect of extract
With conventional antidiabetic drug glibenclamide as positive control, by normal mouse and diabetic mice are carried out glucose tolerance examination
Test (GTT) and blood sugar lowering therapeutic test, have studied the hypoglycemic activity of U.S. rattan fruit leaf water extract.Result shows, 50mg/kg
BW dosage group can significantly reduce mouse blood sugar level, controls within normal range by the blood glucose value of mice, the most upon administration
In the range of 1-3h, its effect is better than glibenclamide；Illustrate that the water extract of U.S. rattan fruit leaf can be obviously improved the height of diabetic mice
Blood glucose symptom, has good hypoglycemic activity.U.S. rattan fruit leaf water extract impact such as Fig. 1 on blood glucose in diabetic mice level
Shown in.
The pharmacodynamic experiment of embodiment 4. embodiment 2
With reference to embodiment 3, changing embodiment 1 therein into embodiment 2, other are constant.Result shows, 50mg/kg BW dosage
Group can significantly reduce mouse blood sugar level, control within normal range by the blood glucose value of mice, the most upon administration 1-3h
In the range of its effect be better than glibenclamide；Illustrate that U.S. rattan fruit leaf (water+ethanol) extract can be obviously improved diabetic mice
Hyperglycemic symptoms, has good hypoglycemic activity.
Claims (9)
1. U.S. rattan fruit leaf extract application in preparing hypoglycemic drug.
Apply the most as claimed in claim 1, it is characterised in that the extracting method of described U.S. rattan fruit leaf extract includes as follows
Step: take U.S. rattan fruit leaf, add solvent and decoct extraction, filter extracting solution, concentrate.
Apply the most as claimed in claim 2, it is characterised in that described solvent is water or ethanol or its mixture.
Apply the most as claimed in claim 2, it is characterised in that the consumption of described solvent is the 1-40 of U.S. rattan fruit foliage weight
Times.
Apply the most as claimed in claim 4, it is characterised in that the consumption of described solvent is the 8-20 of U.S. rattan fruit foliage weight
Times.
Apply the most as claimed in claim 5, it is characterised in that the consumption of described solvent is the 10-15 of U.S. rattan fruit foliage weight
Times.
Apply the most as claimed in claim 2, it is characterised in that the number of times of described solvent extraction is 1-3 time, and each 0.2-6 is little
Time.
Apply the most as claimed in claim 2, it is characterised in that when described concentration refers to be concentrated into 25 DEG C, relative density is 1.1
～1.3.
9. contain the pharmaceutical composition of U.S. rattan fruit leaf extract described in claim 1.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610618692.5A CN106074671A (en) | 2016-08-02 | 2016-08-02 | U.S. rattan fruit leaf extract application in preparing hypoglycemic drug |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610618692.5A CN106074671A (en) | 2016-08-02 | 2016-08-02 | U.S. rattan fruit leaf extract application in preparing hypoglycemic drug |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN106074671A true CN106074671A (en) | 2016-11-09 |
Family
ID=57479921
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201610618692.5A Pending CN106074671A (en) | 2016-08-02 | 2016-08-02 | U.S. rattan fruit leaf extract application in preparing hypoglycemic drug |
Country Status (1)
| Country | Link |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107279403A (en) * | 2017-08-02 | 2017-10-24 | 广西宁明县星雨生物资源开发有限公司 | The preparation method of U.S. rattan fruit leaf health preserving tea |
| CN108523077A (en) * | 2018-03-09 | 2018-09-14 | 海南启星生物科技有限公司 | Compound seasoner and preparation method |
| CN112494531A (en) * | 2020-10-15 | 2021-03-16 | 华南农业大学 | Ampelopsis grossedentata leaf extract and extraction method and application thereof |
-
2016
- 2016-08-02 CN CN201610618692.5A patent/CN106074671A/en active Pending
Non-Patent Citations (2)
| Title |
|---|
| ANA KARINA LIMA NASCIMENTO.ET AL.: "Antioxidant and Antiproliferative Activities of Leaf Extracts from Plukenetia volubilis Linneo (Euphorbiaceae)", 《EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE》 * |
| 卢尔宾: "《把中国人的营养装进"盘子"》", 31 October 2013, 吉林科学技术出版社 * |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107279403A (en) * | 2017-08-02 | 2017-10-24 | 广西宁明县星雨生物资源开发有限公司 | The preparation method of U.S. rattan fruit leaf health preserving tea |
| CN108523077A (en) * | 2018-03-09 | 2018-09-14 | 海南启星生物科技有限公司 | Compound seasoner and preparation method |
| CN112494531A (en) * | 2020-10-15 | 2021-03-16 | 华南农业大学 | Ampelopsis grossedentata leaf extract and extraction method and application thereof |
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Application publication date: 20161109 |
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