CN106074653A - A kind of Chinese medicine composition of cure scapulohumeral periarthritis - Google Patents

A kind of Chinese medicine composition of cure scapulohumeral periarthritis Download PDF

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CN106074653A
CN106074653A CN201610703625.3A CN201610703625A CN106074653A CN 106074653 A CN106074653 A CN 106074653A CN 201610703625 A CN201610703625 A CN 201610703625A CN 106074653 A CN106074653 A CN 106074653A
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rhizoma
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CN106074653B (en
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刘晓斌
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刘晓斌
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/23Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A61K36/236Ligusticum (licorice-root)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/36Skin; Hair; Nails; Sebaceous glands; Cerumen; Epidermis; Epithelial cells; Keratinocytes; Langerhans cells; Ectodermal cells
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/56Materials from animals other than mammals
    • A61K35/62Leeches; Worms, e.g. cestodes, tapeworms, nematodes, roundworms, earth worms, ascarids, filarias, hookworms, trichinella or taenia
    • AHUMAN NECESSITIES
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    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/56Materials from animals other than mammals
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    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/11Pteridophyta or Filicophyta (ferns)
    • AHUMAN NECESSITIES
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    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/17Gnetophyta, e.g. Ephedraceae (Mormon-tea family)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/23Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A61K36/232Angelica
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/23Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A61K36/237Notopterygium
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/23Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A61K36/238Saposhnikovia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/28Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/28Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A61K36/286Carthamus (distaff thistle)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/54Lauraceae (Laurel family), e.g. cinnamon or sassafras
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/67Piperaceae (Pepper family), e.g. Jamaican pepper or kava
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    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/88Liliopsida (monocotyledons)
    • A61K36/906Zingiberaceae (Ginger family)
    • A61K36/9066Curcuma, e.g. common turmeric, East Indian arrowroot or mango ginger
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    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/06Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K2236/00Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30Extraction of the material
    • A61K2236/33Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/331Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K2236/00Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/50Methods involving additional extraction steps
    • A61K2236/51Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K2236/00Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/50Methods involving additional extraction steps
    • A61K2236/53Liquid-solid separation, e.g. centrifugation, sedimentation or crystallization

Abstract

The invention provides a kind of Chinese medicine composition treating calculus, it is made up of the crude drug of following weight portion: Fructus Aurantii Immaturus 39, Radix Cudraniae 9 20, Radix Cirsii Japonici 9 15, Herba Artemisiae Scopariae 6 15, Talcum 10 20, Radix Et Rhizoma Rhei 1 10, Natrii Sulfas 6 12, Rhizoma Imperatae 5 30, Fructus Gardeniae 3 10, Herba Lysimachiae 15 60, Herba Taraxaci 9 15, Radix Cyathulae 6 15, Fructus Forsythiae 6 15, Radix Curcumae 5 12, Semen Plantaginis 9 15, Herba Salviae Chinensis 6 20.

Description

A kind of Chinese medicine composition of cure scapulohumeral periarthritis
One technical field
The present invention relates to the field of Chinese medicines, specifically, the present invention relates to the Chinese medicine composition of cure scapulohumeral periarthritis.
Two background technologies
Scapulohumeral periarthritis is the chronic aseptic inflammation of the soft tissues such as shoulder joint Surrounding muscles, tendon, synovial bursa and joint capsule.Inflammation Cause the outer adhesion of intraarticular, thus affect the activity of shoulder joint.Its lesion characteristic is extensive, and i.e. pain is extensive, function limitation is wide General, tenderness is extensive.Scapulohumeral periarthritis symptom in early days is shoulder pain;The symptom in mid-term is that shoulder pain adds partial function obstacle;Evening The symptom of phase is that shoulder pain adds severe dysfunction and amyotrophy.Scapulohumeral periarthritis is the health of patient and life brings many Damage.
At present, the cause of disease of scapulohumeral periarthritis is studied clear the most completely, it is considered that onset is many because of shoulder joint surrounding tissue, such as flesh Thorax, synovial bursa etc. are subject to, caused by freezing, wound, infection, also have patient to be caused by rheumatism.At present, clinical treatment, alleviation shoulder The medicine for external use kind of Zhou Yan is few, and doctor trained in Western medicine mainly uses analgesic drug product ointment or plaster (such as flurbiprofen Babu cream Japan three large bamboo hats with a conical crown and broad brim Pharmaceutical Co., Ltd's effective ingredient is flurbiprofen bar cloth), the treatment thoughts of the traditional Chinese medical science predominantly invigorating qi and dredging collateral, invigorate blood circulation be main (as QIZHENG XIAOTONG TIE cream Qizheng Tibetan Medicine limited company is mainly composed of Radix Lamiophlomidis Rotatae and Rhizoma Curcumae Longae and congex spray correction Pharmaceutical Group Plc is mainly composed of Radix Angelicae Sinensis, the Radix Angelicae Dahuricae, Rhizoma Zingiberis, Herba Ephedrae, Radix Aconiti, Radix Aconiti Kusnezoffii, Rhizoma Atractylodis, Borneolum Syntheticum etc.), these The major defect of medicine is that alleviating pain timeliness is short, it is impossible to fundamentally pain relieving, so that scapulohumeral periarthritis does not heals, the most seriously Affect work and quality of life.
Three summary of the invention
On the one hand, the invention provides a kind of Chinese medicine composition for cure scapulohumeral periarthritis, former including following weight portion Material medicine: Rhizoma Chuanxiong 3-10, Flos Carthami 3-10, stir-baked SQUAMA MANITIS 5-10, Pheretima 4-9, Radix Angelicae Sinensis 5-15.
Further aspect, the Chinese medicine composition for cure scapulohumeral periarthritis that the present invention provides, former by following weight portion Material medicine is made: Rhizoma Chuanxiong 3-10, Flos Carthami 3-10, Radix Angelicae Pubescentis 3-10, Herba Ephedrae 2-9, Herba Lycopodii 3-12, Ramulus Cinnamomi 3-10, Radix Saposhnikoviae 5-9, Xian Grass 9-12, stir-baked SQUAMA MANITIS 5-10, Pheretima 4-9, Rhizoma Et Radix Notopterygii 3-10, Radix Angelicae Sinensis 5-15, Rhizoma Curcumae Longae 3-10, Caulis Piperis Kadsurae 6-12, Bombyx mori L. 5-15.
Further aspect, the Chinese medicine composition for cure scapulohumeral periarthritis that the present invention provides, former by following weight portion Material medicine is made: Rhizoma Chuanxiong 10, Flos Carthami 10, Radix Angelicae Pubescentis 5, Herba Ephedrae 9, Herba Lycopodii 3, Ramulus Cinnamomi 3, Radix Saposhnikoviae 9, Herba Siegesbeckiae 10, stir-baked SQUAMA MANITIS 5, Pheretima 5, Rhizoma Et Radix Notopterygii 3, Radix Angelicae Sinensis 10, Rhizoma Curcumae Longae 10, Caulis Piperis Kadsurae 6, Bombyx mori L. 10.
Further aspect, the Chinese medicine composition for cure scapulohumeral periarthritis that the present invention provides is ointment.
On the other hand, present invention also offers the preparation method of the above-mentioned Chinese medicine composition for cure scapulohumeral periarthritis, including Step:
A) pulverize: take the crude drug of required weight portion, pulverize respectively, cross 500 mesh sieves, obtain raw material medicated powder;
B) pouring in medicinal cupping by the raw material medicated powder that step a) obtains, add the clear water of 200 parts, slow fire boils, and boils Boil 1 hour;
C) filter: flame-out cooling, the medicine boiled is filtered, filters medicinal residues;
D) paste producing: add appropriate thickening agent in the medicinal liquid filtered, make ointment.
Four accompanying drawing explanations
Fig. 1 is the typical tendon section of group 1,2 and 5;
Fig. 2 is the typical tendon section of group 3 and 4.
Five detailed description of the invention
The preparation of embodiment 1 Chinese medicine composition of the present invention
Prepare the Chinese medicine composition of the present invention in accordance with the following methods:
Pulverize: take the crude drug of following weight portion: Rhizoma Chuanxiong 10, Flos Carthami 10, Radix Angelicae Pubescentis 5, Herba Ephedrae 9, Herba Lycopodii 3, Ramulus Cinnamomi 3, anti- Wind 9, Herba Siegesbeckiae 10, stir-baked SQUAMA MANITIS 5, Pheretima 5, Rhizoma Et Radix Notopterygii 3, Radix Angelicae Sinensis 10, Rhizoma Curcumae Longae 10, Caulis Piperis Kadsurae 6, Bombyx mori L. 10, pulverize, mistake respectively 500 mesh sieves, obtain raw material medicated powder;
Pouring in medicinal cupping by the raw material medicated powder obtained, add the clear water of 200 parts, slow fire boils, and boils that to boil 1 little Time;
Filter: flame-out cooling, the medicine boiled is filtered, filters medicinal residues;
Paste producing: add appropriate thickening agent in the medicinal liquid filtered and (buy from Shanghai Pin Lun Trade Co., Ltd., specifically become Divide and do not indicate), make ointment.
Embodiment 2 verifies the effect of Chinese medicine composition of the present invention on rabbit scapulohumeral periarthritis model
Modeling method:
Choose healthy rabbits 60, male and female half and half, body weight 2-3kg about 6 monthly ages;Wipe out outside the right shoulder of rabbit about The rabbit hair of 6cmX6cm, makes rabbit prostrate, two hind legs and left fore is fixed on platform, and right fore is fixing with horizontal shaker to be connected, with 240 times/min frequency, 1.5cm amplitude parallel shake shoulder joint, continue 4h, continuous 3d every day;Subsequently by shoulder sleeve bag with water-soaked The rear dress ice cube right shoulder of external application rabbit, will change time to the greatest extent when ice melting, and every day continues 4h, continuous 3d;With shake joint for the first time Shi Wei 1 day, during by the 20th day, selects the rabbit 50 being in the scapulohumeral periarthritis stiff phase to be served only for experiment by pathological observation result, with Machine is divided into 5 groups.
Use medicine
Group 1: flurbiprofen Babu cream Japan three large bamboo hat with a conical crown and broad brim Pharmaceutical Co., Ltd by specification every day twice;
Group 2: QIZHENG XIAOTONG TIE cream Qizheng Tibetan Medicine limited company by specification every day twice;
Group 3: congex spray Xiuzheng Pharmaceutical Group Co., Ltd by specification is three times a day;
Group 4: Chinese medicine composition ointment of the present invention (embodiment 1) is three times a day;
Group 5: normal saline is smeared three times a day;
Medication continues 14 days altogether
Indexs measure:
Treatment start before, treatment terminate after, take rabbit ear arterial blood 1ml for detecting serum 5-HT and PGE2Content;
After treatment terminates, use 10% chloral hydrate to carry out auricular vein anesthesia, take biceps brachii m. same position, phase respectively With the piece of tissue of size, piece of tissue being put on ice face, 0.9% sodium chloride injection rinsed clean, filter paper blots, and claims quality, presses The ratio of 10% adds homogenate medium in tissue, shreds piece of tissue with eye scissors in ice-water bath, then ultrasonic in ice bath After being homogenized 30 seconds, 4 DEG C, 2000r/min be centrifuged 10min, take supernatant for detecting muscle 5-HT and PGE2Content.
PGE2ELISA method is all used to detect with 5-HT content.
After treatment terminates, taking biceps brachii m. tendon, size keeps consistent, piece of tissue is placed on ice face, uses 0.9% chlorination Sodium injection rinses, and puts into 20% formalin and fixes 1 week, and tap water rinses 24h, and graded ethanol is dehydrated, and dimethylbenzene is transparent, stone Wax embeds, sections observation muscle form.
Experimental result:
Each group rabbit anteserum and muscle 5-HT content (ng/ml meansigma methods ± s):
Group Serum before treatment Serum after treatment Muscle
1 23.1±2.5 14.1±3.5 14.8±1.5
2 22.0±2.0 14.9±3.3 14.5±3.1
3 21.8±1.1 16.7±2.0 15.9±1.2
4 23.0±2.5 15.0±2.8 14.1±2.2
5 22.5±1.3 23.8±3.2 26.7±2.4
Each group rabbit anteserum and muscle PGE2Content (pg/ml meansigma methods ± s):
Data show, after using each group of medicine, 5-HT level is all decreased obviously, and wherein flurbiprofen Babu cream group declines The most obvious, congex spray group is least obvious, and Chinese medicine composition of the present invention is similar with QIZHENG XIAOTONG TIE cream effect;Use each group of medicine After thing, PGE2Level the most all has certain decline, but flurbiprofen Babu cream group and QIZHENG XIAOTONG TIE cream group fall are the lowest In Chinese medicine composition group of the present invention and congex spray group.
5-HT is the primary transmitter of scapulohumeral periarthritis pain, PGE2In addition to induced pain effect, it also it is the important medium of inflammatory reaction.On State result and further demonstrate that Chinese medicine refers to table (analgesia 5-HT) double (PGE that effects a permanent cure2) advantage.In terms of comprehensive function, the present invention's Chinese medicine composition, also superior to existing Chinese medicine preparation, is particularly reducing PGE2Aspect becomes apparent from.
Tendon fiber is observed and is shown:
Organizing 5 tendon tissue epithelial cell malalinements, hypertrophy about 4-6 layer, epithelium deep layer Descending fibers increases, and structure causes Close, fiber alignment is uneven.Group 1,2 situations are similar (see accompanying drawing 1) therewith;
Group 3 and group 4 tendon tissue epithelial hyperplasia about 2,3 layers, hence it is evident that less than group 5, although upper subcutaneous connective tissue is also Densification, but fiber alignment is relatively neat (see accompanying drawing 2).
These morphologic observation results can be with PGE2Content results is confirmed mutually, it was demonstrated that in Chinese medicine, the particularly present invention Drug composition analgesia outside, the effect a permanent cure effect good to scapulohumeral periarthritis.
Embodiment 3: the real application data of Chinese medicine composition of the present invention
Experimental program:
Choosing stiff phase scapulohumeral periarthritis patient 30 people, men and women is random, is equally divided into three groups.Give congex spray respectively (to repair Positive Pharmaceutical Group Plc by specification is three times a day), Chinese medicine composition of the present invention (embodiment 1 is three times a day), ten thousand Leading to JINGU PIAN (oral medicine by specification dosage), continued treatment two weeks, period, in addition to routine is massaged, does not use any other medicine With acupuncture and moxibustion therapy mode.Treatment continues three weeks altogether.
Symptom score standard:
1 point: mild symptoms, do not affect life and work;
2 points: symptom is heavier, affect live and work, but can stand;
3 points: serious symptom, it is impossible to orthobiosis and work, it is difficult to stand.
Decimal can be taken between 1 and 3 and further indicate that the order of severity.
Mark before and after each group treatment (average ± s)
Before treatment After treatment
Congex spray 2.7±0.5 2.0±0.4
Chinese medicine composition of the present invention 2.8±0.4 1.7±0.7
WANTONG JINGU PIAN 2.7±0.7 2.1±0.7
The Chinese medicine composition actual clinical effect of the visible present invention is the most obvious, is better than being all the congex spray of medicine for external use Agent and conventional oral medicinal herb medicine WANTONG JINGU PIAN.

Claims (5)

1. for a Chinese medicine composition for cure scapulohumeral periarthritis, including the crude drug of following weight portion: Rhizoma Chuanxiong 3-10, Flos Carthami 3- 10, stir-baked SQUAMA MANITIS 5-10, Pheretima 4-9, Radix Angelicae Sinensis 5-15.
2. the Chinese medicine composition described in claim 1, is made up of the crude drug of following weight portion: Rhizoma Chuanxiong 3-10, Flos Carthami 3-10, solely Live 3-10, Herba Ephedrae 2-9, Herba Lycopodii 3-12, Ramulus Cinnamomi 3-10, Radix Saposhnikoviae 5-9, Herba Siegesbeckiae 9-12, stir-baked SQUAMA MANITIS 5-10, Pheretima 4-9, Rhizoma Et Radix Notopterygii 3-10, Radix Angelicae Sinensis 5-15, Rhizoma Curcumae Longae 3-10, Caulis Piperis Kadsurae 6-12, Bombyx mori L. 5-15.
3. the Chinese medicine composition described in claim 2, is made up of the crude drug of following weight portion: Rhizoma Chuanxiong 10, Flos Carthami 10, Radix Angelicae Pubescentis 5, Herba Ephedrae 9, Herba Lycopodii 3, Ramulus Cinnamomi 3, Radix Saposhnikoviae 9, Herba Siegesbeckiae 10, stir-baked SQUAMA MANITIS 5, Pheretima 5, Rhizoma Et Radix Notopterygii 3, Radix Angelicae Sinensis 10, Rhizoma Curcumae Longae 10, Caulis Piperis Kadsurae 6, Bombyx mori L. 10.
4. the Chinese medicine composition of any one of claim 1-3, it is ointment.
5. the preparation method of the Chinese medicine composition of claim 4, including step:
A) pulverize: take the crude drug of required weight portion, pulverize respectively, cross 500 mesh sieves, obtain raw material medicated powder;
B) pouring in medicinal cupping by the raw material medicated powder that step a) obtains, add the clear water of 200 parts, slow fire boils, and boils and boils 1 Hour;
C) filter: flame-out cooling, the medicine boiled is filtered, filters medicinal residues;
D) paste producing: add appropriate thickening agent in the medicinal liquid filtered, make ointment.
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CN102309723A (en) * 2011-09-02 2012-01-11 曹世俊 Traditional Chinese medicine composition for treating arthralgia and preparation method of ointment thereof
CN104800267A (en) * 2015-05-13 2015-07-29 林少忠 Rheumatism plaster
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