CN106031708A - Pharmaceutical composition with effects of skin care, wrinkle removing, and anti-aging effect, and preparation method thereof - Google Patents
Pharmaceutical composition with effects of skin care, wrinkle removing, and anti-aging effect, and preparation method thereof Download PDFInfo
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Abstract
The present invention provides a pharmaceutical composition with effects of skin care, wrinkle removing and anti-aging effect, and a preparation method thereof. The pharmaceutical composition comprises, by weight, 2-50 parts of red grape wine, 0.01-0.5 part of salidroside, 0.01-0.5 part of a salvia miltiorrhiza total phenolic acid extract, 0.01-0.5 part of sodium alginate, 0.01-0.5 part of hydrolyzed pearl powder, 1-20 parts of Chinese wolfberry, 1-20 parts of Flos sophorae, 1-20 parts of wheat, 1-20 parts of safflower, 0.01-0.5 part of vitamin C, and 0.01-0.5 part of vitamin E. The research results show that the pharmaceutical composition has effects of lipid oxidation prevention, free radical elimination, fiber cell proliferation promoting, collagen synthesis promoting, skin nourishing, wrinkle removing, cell aging delaying, and significant effect.
Description
Technical field
The invention belongs to medicine and household chemicals technical field, be specifically related to a kind of for protecting
Pharmaceutical composition that skin smoothing wrinkle is anti-ageing and preparation method thereof.
Background technology
Aging is a kind of natural law, be everyone will the thing of experience, especially over three
Ten, hormonal readiness slowly reduces, and the health especially skin losing original physiological equilibrium necessarily goes out
Existing old and feeble sign, adds that operating pressure is huge, unsound daily schedule and air pollution,
Skin function is necessarily caused to go from bad to worse.The feature of skin aging is to follow the string, and wrinkle occurs,
It is dried keratinization, pigment over-deposit etc..Therefore, prevention and delay skin aging have become beauty treatment
One of focus of medical research.
The design of delay skin aging cosmetics and research are had the skin aging machine of directive significance
Reason mainly has free radical theory, photoaging theory, Metabolic disorder causes of senescence, matrix metal egg
White zymetology is said.
During skin aging, free radical is a key factor of skin lesion.Super oxygen
Compound dismutase (SOD) is internal unique metalloenzyme with super oxyradical as substrate, is
The effective scavenger of super oxyradical, under normal physiological conditions, SOD can effectively remove and hinder
Only super oxyradical chain reaction, maintains free radical scavenging and the dynamic equilibrium of generation, protection
Subcutaneous tissue is from the infringement of free radical, thus plays the effect of delay skin aging.Therefore,
Strengthen the activity of free radical defensive ferment, reduce the generation of skin free radical, to the freedom generated
Base is effectively removed, can effective slowing down skin aging.
The most inherent or foeign element causes organism metabolism obstacle, all can cause cell ageing,
Therefore improve the metabolic function of body, promote the metabolism of cell, skin can be made smooth thin
Greasy, therefore promote that the metabolism of cell is also the approach of delay skin aging.
Collagen protein and elastin laminin, as a kind of structural protein, are widely present in the skin of animal,
In tendon and other knot hoof tissues, the tissue rich in collagen protein is easy to show some and year
The physiological change that age is relevant, therefore collagen protein is taken as the weight inquiring into Aging mechanism always
Want index.Due to collagen protein and the loss of elastin laminin in old and feeble skin, cause skin bullet
Property decline, lax, wrinkle increases, and therefore supplements the collagen protein in skin and elastin laminin is
The another important channel of slow down aging.
Long-term sun exposure also results in skin aging or accelerates aging, the ultraviolet in daylight
The moisture-retaining capacity of skin can be destroyed, make pachylosis, wrinkle increase, so being dried is that skin declines
An old key character, therefore repairs the barrier function of skin, and pinning the moisture in skin can
With delay skin aging.
A lot of Chinese medicines have the advantage of integration of edible and medicinal herbs, are widely used in nourishes rough skin slow down aging
In.As Radix Rhodiolae can promote fibroblast division and can promote its synthesis and secretion collagen egg
In vain, the main component rhodioside in Radix Rhodiolae has the strongest defying age, removes the work of free radical
With；Phenolic acids in Radix Salviae Miltiorrhizae has antioxidation, eliminates free radical, the effect of defying age；In Fructus Lycii
Containing a lot of polyphenoils, can well suppress the generation of lipid peroxide, there is the strongest antioxygen
Change function, it is possible to play the effect of skin care slow down aging；Manganese that Margarita powder itself contains, copper, zinc
It is the composition forming SOD Deng three kinds of trace element, is coated with face with Margarita powder, can promote that human skin surpasses
The activity of superoxide dismutase (SOD), suppresses melanic synthesis, keeps whitening skin.This
Outward, owing to SOD has the effect of free radical of removing, therefore skin aging, wrinkling can be prevented；
Although aging is the necessary process of life, but people explore slow down aging, Austria of remaining youthful forever
Secret effort did not the most stop.Along with research that skin aging essence is deepened continuously, from
Chinese medicine is excavated the anti-ageing composition of skin natural, effective, adds in cosmetics, this sky
The Chinese medicine cosmetic so effectively having no side effect will have the most wide prospect.
Summary of the invention
For above-mentioned purpose, technical scheme is as follows:
The present invention provides a kind of pharmaceutical composition anti-ageing for skin protection smoothing wrinkle, and its feature exists
In, described pharmaceutical composition is extracted by each raw material of following parts by weight and is mixed to prepare: Radix seu Herba Tetrastigmatis Hypoglauci
Wine 1-50 part, rhodioside 0.01-0.5 part, Radix Salviae Miltiorrhizae total phenolic acids extract 0.01-0.5 part,
Sodium alginate 0.01-0.5 part, Margarita powder 0.01-0.5 part, Fructus Lycii 1-20 part, Flos Sophorae Immaturus 1-20
Part, Semen Tritici aestivi 1-20 part, Flos Carthami 1-20 part, vitamin C 0.01-0.5 part, vitamin e
0.01-0.5 part.
Preferably, the parts by weight proportioning of described each raw material is as follows: red wine 2-25 part,
Rhodioside 0.02-0.25 part, Radix Salviae Miltiorrhizae total phenolic acids extract 0.02-0.25 part, sodium alginate
0.02-0.25 part, Margarita powder 0.02-0.25 part, Fructus Lycii 2-10 part, Flos Sophorae Immaturus 2-10 part,
Semen Tritici aestivi 2-10 part, Flos Carthami 2-10 part, vitamin C 0.02-0.25 part, vitamin e
0.02-0.25 part.
The present invention also provides for the preparation method of this pharmaceutical composition, and method is selected from:
A: Fructus Lycii, the Flos Sophorae Immaturus, Semen Tritici aestivi, Flos Carthami boiling in prescription, filter, and filtrate concentrates,
It is dried to powder.Facing the used time carries above-mentioned powder with red wine, rhodioside, Radix Salviae Miltiorrhizae total phenolic acids
Take thing, sodium alginate, Margarita powder, vitamin C, vitamin e merging.
B: in prescription, Fructus Lycii, the Flos Sophorae Immaturus, Semen Tritici aestivi, Flos Carthami add alcohol reflux, filters, filter
Liquid concentrates, and is dried to powder.Face the used time by above-mentioned powder and red wine, rhodioside, Radix Salviae Miltiorrhizae
Total phenolic acid extract, sodium alginate, Margarita powder, vitamin C, vitamin e merge.
Extracting in water 2 times in the operation of soak by water described in preparation method A, each water consumption is medicine
Material weight 6-8 times, decocts 1 hour every time.
Concentration operation is 50 DEG C of-70 DEG C of concentrating under reduced pressure, and drying mode is 40 DEG C-60 DEG C vacuum drying
Or be spray-dried.
In ethanol water reflux, extract, operation described in preparation method B, ethanol water backflow carries
Taking 2 times, the consumption of each ethanol water is medical material weight 6-8 times, extracts 1 hour every time；
Described ethanol water concentration is 10%-70%.
Concentration operation for being 50 DEG C of-70 DEG C of concentrating under reduced pressure equally, drying mode be 40 DEG C-60 DEG C true
Sky is dried or is spray-dried.
Dried crushing material preserves, face used time and rhodioside, Radix Salviae Miltiorrhizae total phenolic acids extract,
Sodium alginate, Margarita powder, vitamin C, vitamin e merge, as pharmaceutical composition.
Present invention also offers the purposes of this pharmaceutical composition, be can on addition galenic pharmacy to purposes
The carrier accepted and/or excipient, for preparing the anti-ageing medicine of skin protection smoothing wrinkle, health product, change
Cosmetic, such as facial film, astringent, frost, emulsion, gel etc..
On galenic pharmacy acceptable carrier and/or excipient selected from sodium carboxymethyl cellulose, carbomer,
Sodium polyacrylate, glycerol, propylene glycol, sorbitol, HP-β-CD, polyoxyethylene hydrogen
Change Oleum Ricini RH40, polyoxyethylene hydrogenated Oleum Ricini HS15, stearic acid, glyceryl monostearate
In one or more.
Detailed description of the invention
Below in conjunction with detailed description of the invention, the present invention is further described in detail, is given
Embodiment only for illustrating the present invention rather than in order to limit the scope of the present invention.
Embodiment 1
Weigh Fructus Lycii 10g respectively, Flos Sophorae Immaturus 200g, Semen Tritici aestivi 100g, Flos Carthami 50g add 2880ml
Soak by water 1 hour, 120 mesh stainless (steel) wire natural filtrations, medicinal residues add water 2160ml decoct 1
Hour, 120 mesh stainless (steel) wire natural filtrations, filtrate merges, 60 DEG C of decompressions (-0.09MPa)
Become extractum, extractum 60 DEG C vacuum drying, pulverize, obtain fine powder 48g, addition red wine 20g,
Rhodioside 0.5g, Radix Salviae Miltiorrhizae total phenolic acids extract 2g, sodium alginate 2g, Margarita powder 0.3g,
Vitamin e 4g, vitamin C 0.1g, mix homogeneously.
Embodiment 2
Weigh Fructus Lycii 150g respectively, Flos Sophorae Immaturus 50g, Semen Tritici aestivi 10g, Flos Carthami 150g add 2280ml
Soak by water 1 hour, 120 mesh stainless (steel) wire natural filtrations, medicinal residues add water 2160ml decoct 1
Hour, 120 mesh stainless (steel) wire natural filtrations, filtrate merges, 50 DEG C of decompressions (-0.09MPa)
Become extractum, extractum 40 DEG C vacuum drying, pulverize, obtain fine powder 50g, addition red wine 300g,
Rhodioside 2g, Radix Salviae Miltiorrhizae total phenolic acids extract 0.4g, sodium alginate 0.1g, Margarita powder 0.5g,
Vitamin e 0.2g, vitamin C 0.3g, mix homogeneously.
Embodiment 3
Weigh Fructus Lycii 200g respectively, Flos Sophorae Immaturus 150g, Semen Tritici aestivi 50g, Flos Carthami 10g add 3280ml
10% ethanol water reflux, extract, 1 hour, 120 mesh stainless (steel) wire natural filtrations, medicinal residues add
2460ml 10% ethanol water reflux, extract, 1 hour, 120 mesh stainless (steel) wire natural filtrations,
Filtrate merges, and 70 DEG C of decompressions (-0.09MPa) become extractum, extractum 50 DEG C vacuum drying, powder
Broken, obtain fine powder 55g, add red wine 500g, rhodioside 5g, Radix Salviae Miltiorrhizae total phenolic acids extraction
Thing 0.1g, sodium alginate 0.3g, Margarita powder 5g, vitamin e 0.1g, vitamin C 0.5g,
Mix homogeneously.
Embodiment 4
Weigh Fructus Lycii 50g respectively, Flos Sophorae Immaturus 100g, Semen Tritici aestivi 200g, Flos Carthami 200g add
4400ml30% ethanol water reflux, extract, 1 hour, 120 mesh stainless (steel) wire natural filtrations,
Medicinal residues add 3300ml30% ethanol water reflux, extract, 1 hour, and 120 mesh stainless (steel) wires are natural
Filtering, filtrate merges, and 60 DEG C of decompressions (-0.09MPa) become extractum, and 60 DEG C of vacuum of extractum are done
Dry, to pulverize, obtain fine powder 72g, addition red wine 200g, rhodioside 0.1g, Radix Salviae Miltiorrhizae are total
Phenolic acid extract 0.5g, sodium alginate 0.5g, Margarita powder 0.1g, vitamin e 0.5g, dimension
He orders C 2g, mix homogeneously.
Embodiment 5
Weigh Fructus Lycii 100g respectively, Flos Sophorae Immaturus 10g, Semen Tritici aestivi 150g, Flos Carthami 100g add
2880ml50% ethanol water reflux, extract, 1 hour, 120 mesh stainless (steel) wire natural filtrations,
Medicinal residues add 2160ml50% ethanol water reflux, extract, 1 hour, and 120 mesh stainless (steel) wires are natural
Filtering, filtrate merges, and 50 DEG C of decompressions (-0.09MPa) become extractum, and 50 DEG C of vacuum of extractum are done
Dry, to pulverize, obtain fine powder 47g, addition red wine 400g, rhodioside 0.3g, Radix Salviae Miltiorrhizae are total
Phenolic acid extract 0.3g, sodium alginate 5g, Margarita powder 2g, vitamin e 0.3g, vitamin
C 5g, mix homogeneously.
Embodiment 6
Weigh Fructus Lycii 100g respectively, Flos Sophorae Immaturus 100g, Semen Tritici aestivi 100g, Flos Carthami 100g add
3200ml70% ethanol water reflux, extract, 1 hour, 120 mesh stainless (steel) wire natural filtrations,
Medicinal residues add 2400ml70% ethanol water reflux, extract, 1 hour, and 120 mesh stainless (steel) wires are natural
Filtering, filtrate merges, and 60 DEG C of decompressions (-0.09MPa) become extractum, and 60 DEG C of vacuum of extractum are done
Dry, pulverize, obtain fine powder 52g, add red wine 100g, rhodioside 3g, Radix Salviae Miltiorrhizae total phenols
Acid extract 3g, sodium alginate 4g, Margarita powder 4g, vitamin e 2g, vitamin C 4g,
Mix homogeneously.
Embodiment 7
Weigh Fructus Lycii 100g respectively, Flos Sophorae Immaturus 100g, Semen Tritici aestivi 100g, Flos Carthami 50g add 2800ml
Soak by water 1 hour, 120 mesh stainless (steel) wire natural filtrations, medicinal residues add water 2100ml decoct 1
Hour, 120 mesh stainless (steel) wire natural filtrations, filtrate merges, 70 DEG C of decompressions (-0.09MPa)
Become extractum, extractum 50 DEG C vacuum drying, pulverize, obtain fine powder 46g, addition red wine 10g,
Rhodioside 1g, Radix Salviae Miltiorrhizae total phenolic acids extract 5g, sodium alginate 1g, Margarita powder 1g, tie up him
Life E 5g, vitamin C 1g, mix homogeneously.
Embodiment 8
Weigh Fructus Lycii 200g respectively, Flos Sophorae Immaturus 100g, Semen Tritici aestivi 100g, Flos Carthami 10g add 3280ml
Soak by water 1 hour, 120 mesh stainless (steel) wire natural filtrations, medicinal residues add water 2640ml decoct 1
Hour, 120 mesh stainless (steel) wire natural filtrations, filtrate merges, 50 DEG C of decompressions (-0.09MPa)
Become extractum, extractum 40 DEG C vacuum drying, pulverize, obtain fine powder 55g, addition red wine 300g,
Rhodioside 4g, Radix Salviae Miltiorrhizae total phenolic acids extract 1g, sodium alginate 0.2g, Margarita powder 0.2g,
Vitamin e 1g, vitamin C 0.2g, mix homogeneously.
Embodiment 9
The medicinal mixture 10g of Example 1 preparation, glycerol adding 10g, carbomer 1g, water
80g, mix homogeneously, 200 revs/min are centrifuged 5 minutes, are divided into 5 parts, are added separately to face
In film paper, pack seals, and obtains the anti-ageing facial film of skin protection smoothing wrinkle.
Embodiment 10
The medicinal mixture 40g of Example 2 preparation, add water 30g, mix homogeneously, and 200
Revs/min centrifugal 5 minutes, add glycerol 20g, carbomer 10g, mix homogeneously, obtain skin protection
The anti-ageing gel of smoothing wrinkle.
Embodiment 11
The medicinal mixture 60g of Example 3 preparation, 50 DEG C of decompressions (-0.09MPa) concentrate
To 30g, add sorbitol 10g, water 100g mix homogeneously, be heated to 70 DEG C；Separately take polyoxy
Ethylene hydrogenation Oleum Ricini HS152g, lanoline 50g, vaseline 10g add to melting, and continue
Continue and be heated to 70 DEG C；Aqueous phase is slowly poured in oil phase, stirring while adding, complete to emulsifying,
Let cool, obtain the anti-ageing ointment of skin protection smoothing wrinkle.
Embodiment 12
Medicinal mixture 30g, glycerol adding 10g, the water 100g mixing of Example 4 preparation is all
Even, it is heated to 70 DEG C；Separately take polyoxyethylene hydrogenated Oleum Ricini RH402g, lanoline 50g,
Vaseline 10g adds to melting, and continues to be heated to 70 DEG C；Aqueous phase is slowly poured in oil phase,
Stirring while adding, complete to emulsifying, let cool, obtain the anti-ageing ointment of skin protection smoothing wrinkle.
Embodiment 13
The medicinal mixture 50g of Example 5 preparation, add water 200g, mix homogeneously, and 200
Revs/min centrifugal 5 minutes, add sorbitol 20g, carbomer 1g, mix homogeneously, must protect
The anti-ageing gel of skin smoothing wrinkle.
Embodiment 14
The medicinal mixture 10g of Example 6 preparation, adds propylene glycol 20g, carbomer 0.2g,
Water 170g, mix homogeneously, 200 revs/min are centrifuged 5 minutes, are divided into 5 parts, are separately added into
In face paper, pack seals, and obtains the anti-ageing facial film of skin protection smoothing wrinkle.
Embodiment 15
Medicinal mixture 20g, glycerol adding 10g, the water 100g mixing of Example 7 preparation is all
Even, it is heated to 70 DEG C；Separately take polyoxyethylene hydrogenated Oleum Ricini RH40 5g, glycerol monostearate
Ester 50g, lanoline 50g, vaseline 10g add to melting, and continue to be heated to 70 DEG C；Will
Aqueous phase is slowly poured in oil phase, stirring while adding, complete to emulsifying, lets cool, obtains skin protection smoothing wrinkle
Anti-ageing frost.
Embodiment 16
The medicinal mixture 20g of Example 8 preparation, adds propylene glycol 50g, water 200g mixing
Uniformly, 70 DEG C it are heated to；Separately take polyoxyethylene hydrogenated Oleum Ricini RH40 10g, lanoline 50g,
Vaseline 20g adds to melting, and continues to be heated to 70 DEG C；Aqueous phase is slowly poured in oil phase,
Stirring while adding, complete to emulsifying, let cool, obtain the anti-ageing breast of skin protection smoothing wrinkle.
The present invention uses tests below to prove the skin protection smoothing wrinkle effect of pharmaceutical composition, and this medicine is described
Compositions is used for the foundation that skin is anti-ageing.
Embodiment 17
The removing of DPPH free radical is tested by pharmaceutical composition
Instrument: generic centrifuge (rotating speed is 1000r/min-10000r/min)；7230G divides
Light photometer (Shanghai analytical tool is wide)；Electric-heated thermostatic water bath.
Reagent: 1,1-diphenyl-2-trinitrophenyl-hydrazine (DPPH), distilled water, ethanol.
Free radical is that a class character is active, has the chemical substance of extremely strong oxidability.Body
The unstable radical produced in metabolic process, in intracellular accumulation, causes unsaturated fatty acid
It is oxidized to peroxide, forms lipofuscin, and make cell and important component thereof such as DNA, egg
White matter and enzyme etc. change and destroy, and cause body aging.Reduce the damage of radical pair body
Wound, it is possible to play the effect of defying age.DPPH is that free radical removed by a kind of sample of evaluating, anti-
The important method of oxidability.
With distilled water, the mixed extract in embodiment 1-8 is diluted to 0.01,0.1 respectively,
0.5,1.0 (mg/ml), then treating excess syndrome example mixed extract 2ml, concentration is 500 μm ol/L
DPPH ethanol 0.5ml and 1.5ml water, mix homogeneously, in the dark place 60 points
Clock, measures its absorbance at 517nm, with corresponding mixed liquor as blank, and with
Following formula calculates its clearance rate:
Clearance rate (%)=(1-(Ai-Aj)/Ac) × 100%
The absorbance of Ac:DPPH+ solvent
Ai: the absorbance of liquid+DPPH solution to be measured
Aj: the absorbance of liquid+solvent to be measured
Each embodiment 1-8 combination extracting solution oxidation resistance assessment result is as shown in table 1.
Test result indicate that, embodiment 1-embodiment 8 extract in vitro 0.01,0.05,
0.5,1.0mg/ml all has the oxidation resistance preferably removing free radical.
Embodiment 18
Pharmaceutical composition is to fibroblast proliferation assay
Fibroblast in skin is the main cell of synthesis collagen protein, fibroblastic
A large amount of increments or fibroblast synthesize and the enhancing of secretion collagen protein ability, can make glue
Former Tot Prot increases, thus slows down the aging of skin.Therefore, research is facilitated fibrocellular
Increment effect is one of important method evaluating sample activity of fighting against senium.
By the cell suspension inoculated, (being configured to concentration is 5*103Individual/ml) it is inoculated in 2 pieces
In 96 orifice plates, after cell attachment, except blank group, it is corresponding that other every holes add 20 μ l
Mixed extract diluent in embodiment 1-8 of concentration, if 4 concentration groups, often group 6
Hole, put incubator (37 DEG C, 5%CO2Cultivating 48h in), being subsequently adding 20 μ l concentration is 5mg/ml
MTT liquid, continue incubator (37 DEG C, 5%CO24h is cultivated in).After taking out enzyme mark version,
Carefully suck the culture fluid in every hole, add dimethyl sulfoxide, mix homogeneously.Use enzyme linked immunological
Detector measures optical density (570nm), by obtaining the relative of sample sets with the comparison of matched group
Appreciation rate.
Each embodiment 1-8 combination extracting solution is to fibroblastic increment Activity Results such as table 2
Shown in.
Test result indicate that, embodiment 1-embodiment 8 extract in vitro 0.01,0.05,
0.5,1.0mg/ml all can promote fibroblastic increment.
Claims (9)
1. one kind is used for the pharmaceutical composition that skin protection smoothing wrinkle is anti-ageing, it is characterised in that described medicine
Compositions is extracted by each raw material of following parts by weight and is mixed to prepare: red wine 2-50 part,
Rhodioside 0.01-0.5 part, Radix Salviae Miltiorrhizae total phenolic acids extract 0.01-0.5 part, sodium alginate
0.01-0.5 part, hydrolyzed pearl powder 0.01-0.5 part, Fructus Lycii 1-20 part, Flos Sophorae Immaturus 1-20 part,
Semen Tritici aestivi 1-20 part, Flos Carthami 1-20 part, vitamin C 0.01-0.5 part, vitamin e 0.01-0.5
Part.
Pharmaceutical composition the most according to claim 1, it is characterised in that described each former
Material parts by weight proportioning as follows: red wine 1-25 part, rhodioside 0.02-0.25 part,
Radix Salviae Miltiorrhizae total phenolic acids extract 0.02-0.25 part, sodium alginate 0.02-0.25 part, hydrolyzed pearl
Powder 0.02-0.25 part, Fructus Lycii 2-10 part, Flos Sophorae Immaturus 2-10 part, Semen Tritici aestivi 2-10 part, red
Flower 2-10 part, vitamin C 0.02-0.25 part, vitamin e 0.02-0.25 part.
Pharmaceutical composition the most according to claim 1 and 2, it is characterised in that described medicine
The preparation method of compositions, is selected from:
A: Fructus Lycii, the Flos Sophorae Immaturus, Semen Tritici aestivi, Flos Carthami boiling in prescription, filter, and filtrate concentrates,
It is dried to powder.Facing the used time carries above-mentioned powder with red wine, rhodioside, Radix Salviae Miltiorrhizae total phenolic acids
Take thing, sodium alginate, hydrolyzed pearl powder, vitamin C, vitamin e merging.
B: in prescription, Fructus Lycii, the Flos Sophorae Immaturus, Semen Tritici aestivi, Flos Carthami add alcohol reflux, filters, filtrate
Concentrate, be dried to powder.Face the used time by total to above-mentioned powder and red wine, rhodioside, Radix Salviae Miltiorrhizae
Phenolic acid extract, sodium alginate, hydrolyzed pearl powder, vitamin C, vitamin e merge.
Preparation method the most according to claim 3, it is characterised in that preparation method A institute
Stating extracting in water 2 times in the operation of soak by water, each water consumption is medical material weight 6-8 times, often
Secondary decoction 1 hour.
Preparation method the most according to claim 3, it is characterised in that preparation method A
Described concentration operation is 60 DEG C of concentrating under reduced pressure or spray drying.
Preparation method the most according to claim 3, it is characterised in that preparation method B
Ethanol water reflux, extract, 2 times, each second in described ethanol water reflux, extract, operation
The consumption of alcohol-water solution is medical material weight 6-8 times, extracts 1 hour every time；Described ethanol water
Solution concentration is 10%-70%.
Pharmaceutical composition the most according to any one of claim 1 to 6, it is characterised in that
Described compositions also comprises acceptable carrier and/or excipient on galenic pharmacy, protects for preparation
The anti-ageing medicine of skin smoothing wrinkle, health product, cosmetics, as facial film, astringent, frost, emulsion,
Gel.
Pharmaceutical composition the most according to claim 7, it is characterised in that described galenic pharmacy
Upper acceptable carrier and/or excipient are selected from sodium carboxymethyl cellulose, carbomer, polyacrylic acid
Sodium, glycerol, propylene glycol, sorbitol, HP-β-CD, polyethylene glycol hydrogenated Semen Ricini
In oil RH40, polyoxyethylene hydrogenated Oleum Ricini HS15, stearic acid, glyceryl monostearate one
Plant or multiple.
Pharmaceutical composition the most according to any one of claim 1 to 8, it is characterised in that
The application of described compositions is for preparing the anti-ageing medicine of skin protection smoothing wrinkle, health product, cosmetics,
Such as facial film, astringent, frost, emulsion, gel.
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| CN201510116806.1A CN106031708A (en) | 2015-03-17 | 2015-03-17 | Pharmaceutical composition with effects of skin care, wrinkle removing, and anti-aging effect, and preparation method thereof |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2023083226A1 (en) * | 2021-11-10 | 2023-05-19 | 山东恒鲁生物科技有限公司 | α-SALIDROSIDE, AND PREPARATION METHOD THEREFOR AND APPLICATION THEREOF |
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