CN106008367A - Synthesis method of azoxystrobin - Google Patents
Synthesis method of azoxystrobin Download PDFInfo
- Publication number
- CN106008367A CN106008367A CN201510803481.4A CN201510803481A CN106008367A CN 106008367 A CN106008367 A CN 106008367A CN 201510803481 A CN201510803481 A CN 201510803481A CN 106008367 A CN106008367 A CN 106008367A
- Authority
- CN
- China
- Prior art keywords
- azoxystrobin
- synthesis method
- present
- fluoxastrobin
- synthetic method
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/52—Two oxygen atoms
Abstract
The invention relates to a synthesis method of azoxystrobin. Innovatively, the method provided by the invention uses clean dimethyl carbonate to replace the traditional high toxic dimethyl sulfate to serve as a methylation reagent, not only increases the single-step yield from 80% to 90%, but also realizes clean production.
Description
Technical field
The present invention relates to a kind of Fluoxastrobin synthetic method, belong to technical field of pesticide.
Background technology
Fluoxastrobin is a kind of efficient, wide spectrum, new type bactericide; have Uptake and translocation, prevent, protect, the multiple action such as treatment; sprouting and the generation of almost all of mycota (Ascomycotina, Basidiomycotina, Mastigomycotina and Deuteromycotina) pathogenic bacteria spore can be suppressed, it is possible to control mycelial growth.And may also suppress Spores to invade; there is good protection activity; effectively control the various fungal diseases of the plants such as vegetable, fruit tree, flowers, such as powdery mildew, downy mildew, scab, anthrax, rust, epidemic disease, glume blight, net blotch, rice blast etc. comprehensively.Especially powdery mildew of strawberry, melon powdery mildew, powdery mildew of cucumber, pear scab there is specially good effect.
Therefore a kind of cleaning is provided to produce and improve the Fluoxastrobin synthetic method of yield and just seem highly desired.
Summary of the invention
The present invention is directed to drawbacks described above, it is therefore intended that provide one can improve yield, it is achieved the Fluoxastrobin synthetic method that cleaning produces.
For this technical solution used in the present invention it is:
The invention have the advantage that the present invention innovates uses cleaning dimethyl carbonate to replace traditional high poison dimethyl sulfate to make methylating reagent, not only improves single step yield and brings up to 90% from 80%, and achieves cleaning and produce.
Detailed description of the invention
The technical solution used in the present invention is:
。
It is an object of the invention to provide a kind of new synthetic route, content and correlated response condition (such as temperature, response time etc.) as component each in raw material all can be obtained by conventional means, it is not the innovative point of the present invention, is not described.
Through actually detected, generally can reach more than 92% according to the method fenoxanil condensation yield of synthetic route of the present invention, individual other can reach more than 95%, therefore the synthetic route of the present invention provides a kind of brand-new synthetic method, has great using value.
Claims (1)
1. Fluoxastrobin synthetic method, it is characterised in that follow the steps below:
。
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510803481.4A CN106008367A (en) | 2015-11-20 | 2015-11-20 | Synthesis method of azoxystrobin |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510803481.4A CN106008367A (en) | 2015-11-20 | 2015-11-20 | Synthesis method of azoxystrobin |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN106008367A true CN106008367A (en) | 2016-10-12 |
Family
ID=57082380
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201510803481.4A Pending CN106008367A (en) | 2015-11-20 | 2015-11-20 | Synthesis method of azoxystrobin |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN106008367A (en) |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1206401A (en) * | 1996-02-17 | 1999-01-27 | 巴斯福股份公司 | Process for preparing 2-(2-methylphenyl)-3-methoxyacrylic acid methylester |
| CN101157657A (en) * | 2007-10-24 | 2008-04-09 | 北京颖新泰康科技有限公司 | Method for preparing azoxystrobin and its analogue |
| CN103030598A (en) * | 2012-12-17 | 2013-04-10 | 上海禾本药业有限公司 | Method for preparing strobilurin fungicide |
| WO2014190997A1 (en) * | 2013-05-28 | 2014-12-04 | Cheminova A/S | Process for preparing 4,6-bis(aryloxy)pyrimidine derivatives |
-
2015
- 2015-11-20 CN CN201510803481.4A patent/CN106008367A/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1206401A (en) * | 1996-02-17 | 1999-01-27 | 巴斯福股份公司 | Process for preparing 2-(2-methylphenyl)-3-methoxyacrylic acid methylester |
| CN101157657A (en) * | 2007-10-24 | 2008-04-09 | 北京颖新泰康科技有限公司 | Method for preparing azoxystrobin and its analogue |
| CN103030598A (en) * | 2012-12-17 | 2013-04-10 | 上海禾本药业有限公司 | Method for preparing strobilurin fungicide |
| WO2014190997A1 (en) * | 2013-05-28 | 2014-12-04 | Cheminova A/S | Process for preparing 4,6-bis(aryloxy)pyrimidine derivatives |
Non-Patent Citations (1)
| Title |
|---|
| 贾新明，等: "DMC在有机合成中的应用研究进展", 《广东化工》 * |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20161012 |
|
| RJ01 | Rejection of invention patent application after publication |