CN105999104A - 一种改善内分泌失调导致不孕的药物组合物 - Google Patents
一种改善内分泌失调导致不孕的药物组合物 Download PDFInfo
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Abstract
本发明涉及重要技术领域领域，具体涉及一种改善内分泌失调导致不孕的药物组合物。具体包括金荞麦根4‑8份，苍术1‑3份，生薏仁2‑5份，怀牛膝5‑8份，香附10‑15份，菊花1‑4份，艾叶4‑6份，玉竹2‑5份，鸡血藤1‑3份，千金拔0.5‑2份，麦冬1‑3份，片姜黄0.5‑1.5份，生甘草1‑4份，白扁豆3‑6份，莲子12‑16份，当归5‑9份，百合2‑5份，白芷2‑6份，玫瑰花1‑4份，山药1‑3份，桂圆3‑6份。本发明提供的药物组合物组分配伍合理，治疗效果显著，产品安全性高，无毒副作用。
Description
技术领域
本发明涉及重要技术领域领域，具体涉及一种改善内分泌失调导致不孕的药物组合物。
背景技术
内分泌是人体生理机能的调控者，它是通过分泌激素从而在人体内发挥其特有的调控作用。比如，当细菌进入人体时，便会自动增加分泌胸腺素以抵抗病菌；而女性在经期，雌性激素分泌量减少，孕激素分泌量则会相应增多。如果因为某些病因，引起内分泌腺分泌的激素过多或过少，机体的新陈代谢功能发生紊乱，就会造成内分泌失调，导致内分泌疾病发生。内分泌失调是导致女性不孕的重要原因。其实正常排卵周期的建立需下丘脑-垂体-卵巢轴功能部位的相互配合，其中任何一个部位受到损害都有可能导致不排卵，从而引起无月经、月经稀发、功血等情况，进行可能导致不孕的症状，由于这种内分泌原因导致的不孕症即内分泌失调性不孕。
目前市场上现有的用于治疗内分泌失调的药物多为西药成分，如激素类，其副作用大，而且，功能比较单一，不能从根本上改善人体内分泌失调的问题。因此，如何克服现有技术中的不足，成为我们继续解决的问题。
发明内容
针对现有技术的不足，本发明提供了一种组分配伍合理，治疗效果显著，产品安全性高，无毒副作用的改善内分泌失调导致不孕的药物组合物。
为实现以上目的，本发明通过以下技术方案予以实现：
一种改善内分泌失调导致不孕的药物组合物，由如下重量份的原料组成：金荞麦根4-8份，苍术1-3份，生薏仁2-5份，怀牛膝5-8份，香附10-15份，菊花1-4份，艾叶4-6份，玉竹2-5份，鸡血藤1-3份，千金拔0.5-2份，麦冬1-3份，片姜黄0.5-1.5份，生甘草1-4份，白扁豆3-6份，莲子12-16份，当归5-9份，百合2-5份，白芷2-6份，玫瑰花1-4份，山药1-3份，桂圆3-6份。
进一步的，所述的改善内分泌失调导致不孕的药物组合物，由如下重量份的原料组成：金荞麦根5-7份，苍术2-3份，生薏仁3-4份，怀牛膝6-7份，香附12-14份，菊花2-3份，艾叶4-5份，玉竹3-4份，鸡血藤2-3份，千金拔0.5-1份，麦冬1-2份，片姜黄1-1.5份，生甘草2-3份，白扁豆4-5份，莲子13-15份，当归6-8份，百合3-4份，白芷3-5份，玫瑰花2-3份，山药2-3份，桂圆4-5份。
进一步的，所述的改善内分泌失调导致不孕的药物组合物，由如下重量份的原料组成：金荞麦根5份，苍术2份，生薏仁3份，怀牛膝6份，香附12份，菊花2份，艾叶4份，玉竹3份，鸡血藤2份，千金拔0.5份，麦冬1份，片姜黄1份，生甘草2份，白扁豆4份，莲子13份，当归6份，百合3份，白芷3份，玫瑰花2份，山药2份，桂圆4份。
进一步的，所述的改善内分泌失调导致不孕的药物组合物的制备方法，包括如下步骤：
(1)按量分别称取各原料，洗净备用；
(2)将金荞麦根，苍术和怀牛膝置于砂锅中，加入清水，武火煮开，转文火煎煮2-5h，过滤，得滤液A；
(3)将香附，菊花，艾叶，玉竹，鸡血藤，千金拔，麦冬，片姜黄和生甘草放入醋液中浸泡15-30min，再加入清水，同煮1-2h，过滤，得滤液B；
(4)将白扁豆，莲子，当归，百合，白芷，生薏仁，玫瑰花，山药和桂圆肉清水浸泡1-1.5h，沥干置于砂锅中，加入体积比为0.5-3:3-1:5的滤液A、滤液B和清水，熬煮至软烂，再文火煎煮10-20min，即得。
进一步的，所述步骤(4)中滤液A、滤液B和清水的加入体积比为1.2:2.3:5。
进一步的，所述步骤(4)中文火煎煮时间为16min。
本发明得有益效果为：本发明提供的中药组合物组分配伍合理，治疗效果显著，产品安全性高，无毒副作用；本发明能有效促进女性荷尔蒙的分泌，快速调整内分泌失调，对于改善内分泌失调引起的不孕和头晕头痛等症状有良好的疗效；本发明通过将各种组分有机组合在一起，能舒缓心郁气结，具有助眠安神的功效。此外，本发明提供的制备方法简单，实用性强。
具体实施方式
为使本发明实施例的目的、技术方案和优点更加清楚，下面将结合本发明的实施例，对本发明实施例中的技术方案进行清楚、完整地描述。基于本发明中的实施例，本领域普通技术人员在没有作出创造性劳动前提下所获得的所有其他实施例，都属于本发明保护的范围。
实施例1：
一种改善内分泌失调导致不孕的药物组合物，由如下重量份的原料组成：金荞麦根5份，苍术2份，生薏仁3份，怀牛膝6份，香附12份，菊花2份，艾叶4份，玉竹3份，鸡血藤2份，千金拔0.5份，麦冬1份，片姜黄1份，生甘草2份，白扁豆4份，莲子13份，当归6份，百合3份，白芷3份，玫瑰花2份，山药2份，桂圆4份。
其制备方法，包括如下步骤：
(1)按量分别称取各原料，洗净备用；
(2)将金荞麦根，苍术和怀牛膝置于砂锅中，加入清水，武火煮开，转文火煎煮4h，过滤，得滤液A；
(3)将香附，菊花，艾叶，玉竹，鸡血藤，千金拔，麦冬，片姜黄和生甘草放入醋液中浸泡25min，再加入清水，同煮1.5h，过滤，得滤液B；
(4)将白扁豆，莲子，当归，百合，白芷，生薏仁，玫瑰花，山药和桂圆肉清水浸泡1.3h，沥干置于砂锅中，加入体积比为1.2:2.3:5的滤液A、滤液B和清水，熬煮至软烂，再文火煎煮16min，即得。
实施例2：
一种改善内分泌失调导致不孕的药物组合物，由如下重量份的原料组成：金荞麦根7份，苍术3份，生薏仁4份，怀牛膝7份，香附14份，菊花3份，艾叶5份，玉竹4份，鸡血藤3份，千金拔1份，麦冬2份，片姜黄1.5份，生甘草3份，白扁豆5份，莲子15份，当归8份，百合4份，白芷5份，玫瑰花3份，山药3份，桂圆5份。
其制备方法，包括如下步骤：
(1)按量分别称取各原料，洗净备用；
(2)将金荞麦根，苍术和怀牛膝置于砂锅中，加入清水，武火煮开，转文火煎煮3.5h，过滤，得滤液A；
(3)将香附，菊花，艾叶，玉竹，鸡血藤，千金拔，麦冬，片姜黄和生甘草放入醋液中浸泡30min，再加入清水，同煮1.5h，过滤，得滤液B；
(4)将白扁豆，莲子，当归，百合，白芷，生薏仁，玫瑰花，山药和桂圆肉清水浸泡1h，沥干置于砂锅中，加入体积比为0.5:3:5的滤液A、滤液B和清水，熬煮至软烂，再文火煎煮14min，即得。
实施例3：
一种改善内分泌失调导致不孕的药物组合物，由如下重量份的原料组成：金荞麦根4份，苍术3份，生薏仁2份，怀牛膝8份，香附10份，菊花4份，艾叶4份，玉竹5份，鸡血藤1份，千金拔2份，麦冬1份，片姜黄1.5份，生甘草1份，白扁豆6份，莲子12份，当归9份，百合2份，白芷6份，玫瑰花1份，山药3份，桂圆3份。
其制备方法，包括如下步骤：
(1)按量分别称取各原料，洗净备用；
(2)将金荞麦根，苍术和怀牛膝置于砂锅中，加入清水，武火煮开，转文火煎煮4h，过滤，得滤液A；
(3)将香附，菊花，艾叶，玉竹，鸡血藤，千金拔，麦冬，片姜黄和生甘草放入醋液中浸泡20min，再加入清水，同煮1h，过滤，得滤液B；
(4)将白扁豆，莲子，当归，百合，白芷，生薏仁，玫瑰花，山药和桂圆肉清水浸泡1.5h，沥干置于砂锅中，加入体积比为1.8:1.2:5的滤液A、滤液B和清水，熬煮至软烂，再文火煎煮20min，即得。
实施例4：
一种改善内分泌失调导致不孕的药物组合物，由如下重量份的原料组成：金荞麦根8份，苍术1份，生薏仁5份，怀牛膝5份，香附15份，菊花1份，艾叶6份，玉竹2份，鸡血藤3份，千金拔0.5份，麦冬3份，片姜黄0.5份，生甘草4份，白扁豆3份，莲子16份，当归5份，百合5份，白芷2份，玫瑰花4份，山药1份，桂圆6份。
其制备方法，包括如下步骤：
(1)按量分别称取各原料，洗净备用；
(2)将金荞麦根，苍术和怀牛膝置于砂锅中，加入清水，武火煮开，转文火煎煮3h，过滤，得滤液A；
(3)将香附，菊花，艾叶，玉竹，鸡血藤，千金拔，麦冬，片姜黄和生甘草放入醋液中浸泡15min，再加入清水，同煮2h，过滤，得滤液B；
(4)将白扁豆，莲子，当归，百合，白芷，生薏仁，玫瑰花，山药和桂圆肉清水浸泡1.2h，沥干置于砂锅中，加入体积比为3:1:5的滤液A、滤液B和清水，熬煮至软烂，再文火煎煮10min，即得。以下结合临床资料和典型病例对本发明的有益效果作进一步的说明：
一、临床观察：
1、临床资料：选自2014年6月至2015年6月住院及门诊内分泌失调造成不孕患者204人，平均分为两组，即对照组和实验组；患者年龄为22-35岁，病程1-15个月。
2、治疗方法：实验组：采用本发明提供的药物，每日早晚各服用一次，每次服用200ml，共服用30天。
对照组：每日早晚各服一次市售相关西药，共服用30天。
3、临床治疗效果的评判标准：
(1)治愈：原有症状全部消失；
(2)显著疗效：原有症状部分消失；
(3)好转：原有症状有改善；
(4)无效：原有症状体征无变化。
4、治疗结果如下表所示：
以上实施例仅用以说明本发明的技术方案，而非对其限制；尽管参照前述实施例对本发明进行了详细的说明，本领域的普通技术人员应当理解：其依然可以对前述各实施例所记载的技术方案进行修改，或者对其中部分技术特征进行等同替换；而这些修改或者替换，并不使相应技术方案的本质脱离本发明各实施例技术方案的精神和范围。
Claims (6)
1.一种改善内分泌失调导致不孕的药物组合物，其特征在于，由如下重量份的原料组成：金荞麦根4-8份，苍术1-3份，生薏仁2-5份，怀牛膝5-8份，香附10-15份，菊花1-4份，艾叶4-6份，玉竹2-5份，鸡血藤1-3份，千金拔0.5-2份，麦冬1-3份，片姜黄0.5-1.5份，生甘草1-4份，白扁豆3-6份，莲子12-16份，当归5-9份，百合2-5份，白芷2-6份，玫瑰花1-4份，山药1-3份，桂圆3-6份。
2.如权利要求1所述的改善内分泌失调导致不孕的药物组合物，其特征在于，由如下重量份的原料组成：金荞麦根5-7份，苍术2-3份，生薏仁3-4份，怀牛膝6-7份，香附12-14份，菊花2-3份，艾叶4-5份，玉竹3-4份，鸡血藤2-3份，千金拔0.5-1份，麦冬1-2份，片姜黄1-1.5份，生甘草2-3份，白扁豆4-5份，莲子13-15份，当归6-8份，百合3-4份，白芷3-5份，玫瑰花2-3份，山药2-3份，桂圆4-5份。
3.如权利要求1所述的改善内分泌失调导致不孕的药物组合物，其特征在于，由如下重量份的原料组成：金荞麦根5份，苍术2份，生薏仁3份，怀牛膝6份，香附12份，菊花2份，艾叶4份，玉竹3份，鸡血藤2份，千金拔0.5份，麦冬1份，片姜黄1份，生甘草2份，白扁豆4份，莲子13份，当归6份，百合3份，白芷3份，玫瑰花2份，山药2份，桂圆4份。
4.如权利要求1-3中任一项所述的改善内分泌失调导致不孕的药物组合物的制备方法，其特征在于，包括如下步骤：
(1)按量分别称取各原料，洗净备用；
(2)将金荞麦根，苍术和怀牛膝置于砂锅中，加入清水，武火煮开，转文火煎煮2-5h，过滤，得滤液A；
(3)将香附，菊花，艾叶，玉竹，鸡血藤，千金拔，麦冬，片姜黄和生甘草放入醋液中浸泡15-30min，再加入清水，同煮1-2h，过滤，得滤液B；
(4)将白扁豆，莲子，当归，百合，白芷，生薏仁，玫瑰花，山药和桂圆肉清水浸泡1-1.5h，沥干置于砂锅中，加入体积比为0.5-3:3-1:5的滤液A、滤液B和清水，熬煮至软烂，再文火煎煮10-20min，即得。
5.如权利要求4所述的改善内分泌失调导致不孕的药物组合物，其特征在于，所述步骤(4)中滤液A、滤液B和清水的加入体积比为1.2:2.3:5。
6.如权利要求4所述的改善内分泌失调导致不孕的药物组合物，其特征在于，所述步骤(4)中文火煎煮时间为16min。
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| CN104524335A (zh) * | 2014-12-29 | 2015-04-22 | 张解 | 一种用于女性内分泌失调调理的药丸及制备方法 |
| CN104587397A (zh) * | 2015-01-17 | 2015-05-06 | 王动力 | 一种治疗内分泌失调的中药组合物 |
| CN104740482A (zh) * | 2015-04-24 | 2015-07-01 | 周爱英 | 治疗内分泌失调性不孕的中药组合物及其制备方法 |
| CN104922613A (zh) * | 2015-07-21 | 2015-09-23 | 青岛蓝盛洋医药生物科技有限责任公司 | 一种治疗不孕不育症的药物组合物及其制备方法 |
| CN105362587A (zh) * | 2015-12-02 | 2016-03-02 | 孙金霞 | 一种改善内分泌失调导致的不孕的组合物及其制备方法 |
| CN105560668A (zh) * | 2016-03-02 | 2016-05-11 | 陈红 | 一种治疗免疫性不孕的药物组合物 |
| CN105641334A (zh) * | 2016-03-25 | 2016-06-08 | 北京天科仁祥医药科技有限公司 | 一种用于治疗内分泌失调的组合物 |
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