CN105998429A - Preparation method of preoperative medicine for patients with diabetics - Google Patents
Preparation method of preoperative medicine for patients with diabetics Download PDFInfo
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- CN105998429A CN105998429A CN201610376052.8A CN201610376052A CN105998429A CN 105998429 A CN105998429 A CN 105998429A CN 201610376052 A CN201610376052 A CN 201610376052A CN 105998429 A CN105998429 A CN 105998429A
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Abstract
The invention discloses a preparation method of a preoperative medicine for patients with diabetics. The preparation method comprises the following steps: (1) cleaning the following materials: arenicola cristata, cladosiphon okamuranus, lentinus lepideus fr, longleaf bastardtoadflax herb, laportea violacea gaghep, pineapple peels, moellendorf's spidemoss herb, pyropolyporus formentarius teng, herb of elsholtzia rugulosa hemsl, swamp currant, codariocalyx motorius and eurya hebeclados, removing impurities, airing and crushing the materials, so that particles are prepared; (2) mixing the particulate medicinal materials obtained in the step (1), soaking the materials in water, decocting the materials twice, combining two times of decoctions, and conducting filtering and concentrating; and (3) storing a concentrated solution obtained in the step obtained in the step (2) at low temperature, adding diatomite which serves as a filter aid, conducting filtering, and refrigerating an obtained filtrate at 0-5 DEG C for 24h, so that oral liquid is obtained. The medicine disclosed by the invention is reasonable in prescription, concrete in curative effect, and the medicine is capable of effectively preventing un-healed wounds in patients with diabetics in the orthopedic surgery.
Description
Technical field
The present invention relates to the field of Chinese medicines, be specifically related to a kind of preparation method being applicable to the preoperative medicine of diabetics.
Background technology
The blood glucose that is mainly characterized by of diabetes raises, it it is a kind of metabolic disease, major complications is microangiopathies and macroangiopathy, owing to the diabetics mostly course of disease is longer, nutrient consumption is big, hypoimmunity, simultaneously with vascular lesion make nutrient substance supply that obstacle to occur, the repair ability of local organization reduces；And the rising of blood glucose causes protein synthesis to reduce, decomposition increases, cellular metabolism occurs abnormal, wound fibrocyte hypofunction, epithelial proliferation makes collagen deposition reduce, and the tensile strength of wound is not enough, when wound healing, lack a kind of from hematoblastic somatomedin, cause wound healing delay or do not heal；Hyperglycemia makes the sterilizing power of leukocyte weaken；Internal antibiotic substance (such as antibody, complement etc.) reduces, add the anoxia that vascular lesion causes so that be formed with the most vegetative environment, etc. reason cause diabetics operative incision complication to occur, as courageous and upright secretions persistently occurs, even delayed union.
After diabetics bone surgery, poor healing occurs, use general dressing change in surgical department method to be difficult to make it heal, existing rare preoperative intervention stratege.Accordingly, it would be desirable to a kind of effective and that side effect is little chemoprophylaxis diabetics occurs that wound healing is bad.
Summary of the invention
The technical assignment of the present invention is for above the deficiencies in the prior art, it is provided that the prevention diabetics that a kind of curative effect is affirmed and side effect is little is chosen date for operation and the medicine that wound healing is bad occurred.
The present invention solves the technical scheme of its technical problem: a kind of preparation method being applicable to the preoperative medicine of diabetics, it is characterised in that crude drug includes: Arenicola cristata stimpson. 10～30 parts, Nemacystus decipiens (Sur.) Kuck 15～25 parts, leopard mushroom 5～15 parts, Herba Thesii Longifolii 5～15 parts, bean fiber crops 6～10 parts, pineapple peel 3～10 parts, rock spring grass 6～12 parts, Fomes Fomentarius 3～10 parts, Herba Elsholtziae rugulosae 6～12 parts, Ribes humile Jancz. 2～5 parts, telegraph plant 1～3 parts, microtriche Eurya plant 1～3 parts.
The preparation method of its oral liquid is:
(1) take the Arenicola cristata stimpson. of recipe quantity, Nemacystus decipiens (Sur.) Kuck, leopard mushroom, Herba Thesii Longifolii, bean fiber crops, pineapple peel, rock spring grass, Fomes Fomentarius, Herba Elsholtziae rugulosae, Ribes humile Jancz., telegraph plant, microtriche Eurya plant, clean roguing, dry, be ground into granule；
(2) gained graininess medical material in step (1) is mixed, add water to cover powder 2cm, after soaking 0.5～1h, add up medical material 5～the water of 10 times of weight, decoct 1h, take decocting liquid, filter, then add up the water of 5 times of weight of medical material, secondary decocts 30min, taking twice decocting liquid to merge, filter, when being concentrated into 90 DEG C, relative density is the concentrated solution of 1.2～1.25；
(3) being set to 0～5 DEG C of deepfreeze 24h by concentrated solution in step (2), the concentrated solution after cold preservation adds the filter aid kieselguhr of 0.3%～0.5% weight, filters, and filtrate is placed in 0～5 DEG C of cold preservation 24h, obtains oral liquid.
In prescription: Arenicola cristata stimpson., for the entirety that husky section animal cockscomb is husky；Nature and flavor are salty, cold；GUIXIN warp；Merit can heat-clearing and toxic substances removing；Expelling pus and promoting granulation.
Nemacystus decipiens (Sur.) Kuck, for the frond of Nemacystus decipiens (Sur.) Kuck section plant Nemacystus decipiens (Sur.) Kuck.Nature and flavor are salty, cold；Return liver, lung meridian；Merit can eliminating phlegm and softening indurated mass, inducing diuresis to remove edema.Main goiter；Goiter；Laryngitis；Bronchitis.
Leopard mushroom, for the sporophore of Bai Mo section fungus leneinus lepideus Franch；Nature and flavor are sweet, flat；GUIXIN, spleen channel；Merit can fill blood；Benefit conscience.Main insufficiency of vital energy and blood；Deficiency of both the heart and spleen；Fatigue and weak；Insomnia cardiopalmus.
Herba Thesii Longifolii, comes into leaves Herba Thesii or the herb of Western Regions Herba Thesii for Santalaceae plant；Property arduous, cool；Merit can expelling wind and clearing away heat, spasmolytic；Cure cold, heatstroke, infantile pneumonia, cough, infantile convulsion.
Bean fiber crops, for the Herb of contrayerva grape leaf Chinese mugwort fiber crops band root；Property pungent, temperature；Merit can expelling wind and removing dampness, regulating the function of the stomach to resolve the turbidity；Main air pain of dampness syndrome；Limbs fiber crops are originally；Gastral cavity painful abdominal mass uncomfortable in chest；Stomachache is vomited and diarrhoea.
Pineapple peel, for the peel of bromelia Fructus Ananadis comosi；Nature and flavor are puckery, sweet, flat；Merit can be detoxified, cough-relieving, dysentery relieving.Main cough；Dysentery.
Rock spring grass, for the herb of Aspleniaceae plant tiger tail Asplenium trchomanes L.；Nature and flavor are bitter, sweet, cool；Merit can heat-clearing and toxic substances removing, checking hyperfunction of the liver for relieving convulsion, stop blooding diuresis.Main acute icteric infectious hepatitis；Cough due to lung-heat；Infantile convulsion；Dysuria；Dactylitis；Venom.
Fomes Fomentarius, for the sporophore of On Polyporaceae Fomes fomentarius；Property micro-hardship, flat；Merit can removing food stagnancy, blood stasis dispelling, anticancer；Staple food amasss, the esophageal carcinoma, gastric cancer, uterus carcinoma.
Herba Elsholtziae rugulosae, the herb of Labiatae Elsholtzia species open country embankment；Property is pungent, cool；Merit can dispelling wind to relieve the exterior syndrome, dampness removing；For catching a cold, headache, dyspepsia, acute gastroenteritis, dysentery.
Ribes humile Jancz., for the fruit of saxifragaceae plant Herba Ardisiae Japonicae；Nature and flavor are bitter, flat；Return lung, bladder warp；Merit can expelling wind and clearing away heat；Main cold, fever, cough.
Telegraph plant, pulse family telegraph plant is with all herbal medicine；Nature and flavor are micro-puckery, flat；Merit can be calmed the nerves, calm, promoting tissue regeneration by removing blood stasis, promoting blood circulation and detumescence.Cure mainly neurasthenia, frequent fetal movement.
Microtriche Eurya plant, for the Herb of plant of theaceae microtriche Eurya plant；Nature and flavor are pungent, flat；Merit can be dispeled the wind, detumescence, removing toxic substances, hemostasis.Main rheumatic arthritis；Hepatitis；Innominate toxic swelling；Scald；Traumatic injury；Traumatic hemorrhage；Venom.
Composition principle: wound healing is the normal reaction of body after tissue injury, normal agglutination divides acute inflammation stage, hyperplasia phase and cicatrization phase, in the hyperplasia phase, the diabetics course of disease is longer, hypoimmunity, owing to Patients with Vasculopathy causes anoxia, hyperglycemia causes leukocyte sterilizing ability to reduce, internal antibiotic substance reduces, and makes otch be conducive to bacterial reproduction, and the inflammatory reaction that antibacterial causes will stop skin regeneration；The hyperplasia phase is affected by vascular lesion, patient's local organization repair ability reduces, wound fibroblast (FB) hypofunction, epithelial proliferation makes collagen deposition reduce, the tensile strength of wound is not enough, when wound healing, lack a kind of from hematoblastic somatomedin, cause wound healing delay or do not heal.
Compared with prior art, the invention have the characteristics that:
null1、Arenicola cristata stimpson. coordinates Nemacystus decipiens (Sur.) Kuck to be monarch drug，Arenicola cristata stimpson. contains substantial amounts of taurine and other aminoacid，Facilitation is had for local wound reparation，And Nemacystus decipiens (Sur.) Kuck is frond，Containing xanthin and polysaccharide component in composition，Experimentation shows: Arenicola cristata stimpson.、Nemacystus decipiens (Sur.) Kuck mixed in equal amounts water decoction is used for Rat Experimental scald wound，Can with speedup Wound fibroblasts (FB) propagation (experimental group peak value 71.45 ± 12.04 occurs in 10d，And use the matched group of PBS，The numerical value of 10d is 46.82 ± 11.25，Peak value is 58.67 ± 14.51，Occur in 20d，Two groups of comparing differences are statistically significant)，Arenicola cristata stimpson. is described、Nemacystus decipiens (Sur.) Kuck can promote wound repair，Shifting to an earlier date of peak value the most then means that apoptosis occurs in healing later stage FB，And avoid the formation of scar tissue，Pathologic examination also confirms that: experimental group inflammatory cell disappears relatively early；
2, Herba Thesii Longifolii, Fomes Fomentarius can reach to promote anoxia body microcirculation for mucosa local, accelerate effect that local edema absorbs, and bean fiber crops, Herba Elsholtziae rugulosae have the effect of broad-spectrum antiseptic；Rock spring grass, Ribes humile Jancz. can improve collagen protein catabolism speed, promote wound healing；
3, leopard mushroom, the effect of pineapple peel are to promote the propagation of cell, growth, quickly repair impaired mucosa, promote that smooth muscle actin is expressed；
4, Fomes Fomentarius extract also has the effect promoting keratinocyte motion, coordinates Herba Elsholtziae rugulosae to use, can effectively increase transdermal absorption factor, strengthens drug effect；
5, telegraph plant, microtriche Eurya plant, invigorates blood circulation and holds back blood and go forward side by side, and dosage is about 1/10th of routine dose, its object is to increase medicine overall absorption rate, reduces the medicine local excitation to patient.
Detailed description of the invention
Below in conjunction with practical situation, the detailed description of the invention of the present invention is elaborated.
Embodiment 1, crude drug part by weight is: Arenicola cristata stimpson. 20g, Nemacystus decipiens (Sur.) Kuck 20g, leopard mushroom 10g, Herba Thesii Longifolii 10g, bean fiber crops 8g, pineapple peel 6g, rock spring grass 8g, Fomes Fomentarius 7g, Herba Elsholtziae rugulosae 10g, Ribes humile Jancz. 3g, telegraph plant 1g, microtriche Eurya plant 2g.
The preparation method of embodiment 1 is: Arenicola cristata stimpson., leopard mushroom, Herba Thesii Longifolii, bean fiber crops, pineapple peel, the rock spring grass, Fomes Fomentarius, Herba Elsholtziae rugulosae, Ribes humile Jancz., telegraph plant, microtriche Eurya plant, Nemacystus decipiens (Sur.) Kuck, clean roguing, put into Traditional Chinese medicine decocting earthen pot.Adding cold water and cover powder, soak 60min, intense fire is decocted to boiling, after change slow fire and decoct 30min slowly, decoct 2 times altogether, filtered through gauze collecting decoction, be administered orally at twice.
Embodiment 2, crude drug part by weight is: Arenicola cristata stimpson. 10 parts, Nemacystus decipiens (Sur.) Kuck 25 parts, 5 parts of leopard mushroom, Herba Thesii Longifolii 15 parts, bean fiber crops 6 parts, pineapple peel 3 parts, rock spring grass 12 parts, Fomes Fomentarius 10 parts, Herba Elsholtziae rugulosae 6 parts, Ribes humile Jancz. 2 parts, telegraph plant 3 parts, microtriche Eurya plant 1 part.
Embodiment 3, crude drug part by weight is: Arenicola cristata stimpson. 20 parts, Nemacystus decipiens (Sur.) Kuck 20 parts, 10 parts of leopard mushroom, Herba Thesii Longifolii 10 parts, bean fiber crops 8 parts, pineapple peel 6 parts, rock spring grass 8 parts, Fomes Fomentarius 7 parts, Herba Elsholtziae rugulosae 10 parts, Ribes humile Jancz. 3 parts, telegraph plant 1 part, microtriche Eurya plant 2 parts.
Embodiment 4, crude drug part by weight is: Arenicola cristata stimpson. 30 parts, Nemacystus decipiens (Sur.) Kuck 15 parts, 15 parts of leopard mushroom, Herba Thesii Longifolii 5 parts, bean fiber crops 10 parts, pineapple peel 10 parts, rock spring grass 6 parts, Fomes Fomentarius 3 parts, Herba Elsholtziae rugulosae 12 parts, Ribes humile Jancz. 5 parts, telegraph plant 1 part, microtriche Eurya plant 3 parts.
The oral liquid that embodiment 2 ~ 4 uses is:
(1) take the Arenicola cristata stimpson. of recipe quantity, Nemacystus decipiens (Sur.) Kuck, leopard mushroom, Herba Thesii Longifolii, bean fiber crops, pineapple peel, rock spring grass, Fomes Fomentarius, Herba Elsholtziae rugulosae, Ribes humile Jancz., telegraph plant, microtriche Eurya plant, clean roguing, dry, be ground into granule；
(2) gained graininess medical material in step (1) is mixed, add water to cover powder 2cm, after soaking 0.5～1h, add up medical material 5～the water of 10 times of weight, decoct 1h, take decocting liquid, filter, then add up the water of 5 times of weight of medical material, secondary decocts 30min, taking twice decocting liquid to merge, filter, when being concentrated into 90 DEG C, relative density is the concentrated solution of 1.2～1.25；
(3) being set to 0～5 DEG C of deepfreeze 24h by concentrated solution in step (2), the concentrated solution after cold preservation adds the filter aid kieselguhr of 0.3%～0.5% weight, filters, and filtrate is placed in 0～5 DEG C of cold preservation 24h, obtains oral liquid.
Said medicine efficient combination, coordinates mutually, effectively reaches prevention diabetics operative incision and malunited purpose occurs, and side effect is less.The above results is that clinical data fully proves, relevant information is as follows.
1 object and method.
1.1 object.
1.1.1
Case selection: select a time hallux valgus operation January in July, 2014 ~ 2016 year, and occur together diabetes medical history but good patient 148 example of glycemic control, wherein male 35 example, women 113 example, the age 43-65 year between, the mean age is 51.8 years old, diabetic history 1 ~ 5 year.The good standard of blood glucose control: 1. oral administration of metformin blood sugar lowering, fasting glucose 7 ~ 9mmol/L；2. glycolated hemoglobin is normal.Get rid of: 1. the age is more than 65 years old；2. the course of disease is more than 5 years；3. with serious kidney disease, cardiovascular disease, coagulation disorders or mentally disturbed.
1.1.2
Packet: be divided into matched group 49 example, decoction group 49 example and oral liquid group 50 example.Three groups of patients compare before being administered in age, sex, diabetic condition distribution, and no significant difference (P > 0.05) has comparability.
1.1.3 wound healing criterion: without oozing out, otch skin healing or cicatrix healing.Otch disunion criterion: according to normal clearing time (postoperative 14d), the pale cracking of notching edge, has secretions flow out or have slough.
The most postoperative 14d otch evaluation criterion: good: infecting do not occurs in otch, the red and swollen and situation such as split；Not good enough: otch redness occurs without infecting, split local；Bad: infection of incisional wound, to split.
1.2 method.
The most preoperative interference method: decoction group and oral liquid group patient start oral drugs in one week the most in the preoperative.Decoction group gives gained decoction in the embodiment of the present invention 1；Oral liquid group gives gained oral liquid in the embodiment of the present invention 3.Every day twice.
1.2.3 observation index: otch situation when recording postoperative 14d (the redst and the most swollen, courageous and upright secretions, wound healing), complication and medication related reactions.
1.2.4 statistical analysis: SPSS 18.0 carries out statistical analysis.Measurement data t checks, enumeration data χ2Inspection.
2 results.
After 2.1 3 groups of operation in patients, 14d healing rate compares: when postoperative 14 days, and three groups of patient's disunion rates are respectively as follows: matched group 12.24%(6/49), decoction group 2.04%(1/49), oral liquid group 2%(1/50) and, compare and there is significant difference (χ2=3.85, P ＜ 0.05；χ2=3.95, P ＜ 0.05), it was demonstrated that the medicine that embodiment of the present invention prepares can imitate promotion diabetics post-surgical incisions healing.
2.2 otch evaluations in postoperative 14 days: after 14 days, patient's wound healing situation compares, matched group healing well accounts for 69.39%(34/49), decoction group 93.88%(46/49), oral liquid group 94%(47/50), compare and there is notable statistics difference (χ2=9.80, P ＜ 0.05；χ2=10.07, P ＜ 0.05)；The not good enough matched group that heals is 18.37%(9/49), decoction group 4.08%(2/49), oral liquid group 4%(2/50) and, than less having diversity (χ2=5.02, P ＜ 0.05；χ2=5.17, P ＜ 0.05)；Poor healing comparative control group is 12.24%(6/49), decoction group 2.04%(1/49), oral liquid group 2%(1/50) compare there is significant difference (χ2=3.85, P ＜ 0.05；χ2=3.95, P ＜ 0.05)；It is confirmed that the medicine that embodiment of the present invention prepares can have prevention diabetics to occur that wound healing is bad after choosing date for operation.
2.3 untoward reaction: during drug treatment, decoction group, oral liquid group all occur without substantially local untoward reaction, it was demonstrated that the safety of medicine that embodiment of the present invention prepares is reliable.
3. conclusion.
This result of study shows, the decoction group and the oral liquid group that use the present invention can increase otch healing rate after diabetics bone surgery, and improve healing otch state, and occur without complication reaction, illustrate that medicine prepared by the inventive method has, at the prevention diabetics bad aspect of wound healing of choosing date for operation, the advantage that curative effect is affirmed, safety is higher.
Claims (2)
1. a kind of preparation method being applicable to the preoperative medicine of diabetics, it is characterized in that, being made up of following crude drug: Arenicola cristata stimpson., Nemacystus decipiens (Sur.) Kuck, leopard mushroom, Herba Thesii Longifolii, bean fiber crops, pineapple peel, rock spring grass, Fomes Fomentarius, Herba Elsholtziae rugulosae, Ribes humile Jancz., telegraph plant, microtriche Eurya plant, its preparation method is:
(1) take the Arenicola cristata stimpson. of recipe quantity, Nemacystus decipiens (Sur.) Kuck, leopard mushroom, Herba Thesii Longifolii, bean fiber crops, pineapple peel, rock spring grass, Fomes Fomentarius, Herba Elsholtziae rugulosae, Ribes humile Jancz., telegraph plant, microtriche Eurya plant, clean roguing, dry, be ground into granule；
(2) gained graininess medical material in step (1) is mixed, after soaking, boiling 1h, take decocting liquid, filter, add water, secondary decocts 30min, takes twice decocting liquid and merges, filters, and when being concentrated into 90 DEG C, relative density is the concentrated solution of 1.2～1.25；
(3) being set to 0～5 DEG C of deepfreeze 24h by concentrated solution in step (2), the concentrated solution after cold preservation adds filter aid kieselguhr, filters, and filtrate is placed in 0～5 DEG C of cold preservation 24h, obtains oral liquid.
A kind of preparation method being applicable to the preoperative medicine of diabetics the most according to claim 1, it is characterized by, be made up of following raw material medicine: Arenicola cristata stimpson. 20 parts, Nemacystus decipiens (Sur.) Kuck 20 parts, 10 parts of leopard mushroom, Herba Thesii Longifolii 10 parts, bean fiber crops 8 parts, pineapple peel 6 parts, rock spring grass 8 parts, Fomes Fomentarius 7 parts, Herba Elsholtziae rugulosae 10 parts, Ribes humile Jancz. 3 parts, telegraph plant 1 part, microtriche Eurya plant 2 parts.
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