CN105997304B - Heart valve annulus compression apparatus - Google Patents
Heart valve annulus compression apparatus Download PDFInfo
- Publication number
- CN105997304B CN105997304B CN201610280415.8A CN201610280415A CN105997304B CN 105997304 B CN105997304 B CN 105997304B CN 201610280415 A CN201610280415 A CN 201610280415A CN 105997304 B CN105997304 B CN 105997304B
- Authority
- CN
- China
- Prior art keywords
- fixator
- rack
- surgical thread
- conduit
- seal wire
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/24—Heart valves ; Vascular valves, e.g. venous valves; Heart implants, e.g. passive devices for improving the function of the native valve or the heart muscle; Transmyocardial revascularisation [TMR] devices; Valves implantable in the body
- A61F2/2442—Annuloplasty rings or inserts for correcting the valve shape; Implants for improving the function of a native heart valve
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/24—Heart valves ; Vascular valves, e.g. venous valves; Heart implants, e.g. passive devices for improving the function of the native valve or the heart muscle; Transmyocardial revascularisation [TMR] devices; Valves implantable in the body
- A61F2/2412—Heart valves ; Vascular valves, e.g. venous valves; Heart implants, e.g. passive devices for improving the function of the native valve or the heart muscle; Transmyocardial revascularisation [TMR] devices; Valves implantable in the body with soft flexible valve members, e.g. tissue valves shaped like natural valves
- A61F2/2418—Scaffolds therefor, e.g. support stents
Abstract
The present invention provides heart valve annulus compression apparatus, including syringe needle, conduit, seal wire and two fixators, syringe needle is hollow structure, syringe needle connecting conduit, one fixator is fixed on the distal end of surgical thread, another fixator is flexibly connected with surgical thread, and seal wire is detachably connected with the fixator, and seal wire can promote fixator to be moved in the conduit.In the present invention, a certain position of back lobe annulus is inserted the needle into, seal wire is promoted, the fixator of surgical thread distal end is passed out of conduit, be fixed on annulus wall;Conduit is retracted, inserts the needle into the another location of back lobe annulus, seal wire is promoted, another fixator in surgical thread is passed out of conduit, be fixed on annulus wall;Pull back surgical thread, surgical thread is reduced the distance between two fixators from second fixator being fixed on annulus wall toward recovery so as to pass through, reduce the relative distance for the back lobe annulus being connected with fixator, so that annulus reduces, and then reduce mitral valve orifice area, so as to reduce reflux amount.
Description
Technical field
The present invention relates to medical instruments field, more particularly to a kind of heart valve annulus compression apparatus.
Technical background
Ill bicuspid valve and tricuspid valve are because a variety of causes is frequently necessary to change or repairs.The valve of bicuspid valve and tricuspid valve
Leaf or support tendon may degenerate and weaken, or annulus may be expanded and cause valve leaks, valvular function incompetence.
Due to annulus expand or have a common boundary it is broadening caused by incompetence, it is applicable to do boundary fundoplication.Conventional method is Reed methods, is being had a common boundary
Annulus position is closed with 2-0 hurtless measures linear slit and folds annulus before and after place, and preceding annulus retains 4cm after folding, and 2cm is stayed in back lobe environmental protection.This
Valve function before the shortcomings that method designs has influence on, valve is folded in suture before having part, in addition the easy avulsion of suture, and some patients still need
Seam puts artificial ring.One of ordinary skill in the art are improved Reed methods, are sutured using the double-ended needle with pad at boundary position
Inserting needle.Folded in this technical scheme by pad, suture is not easy avulsion;And annulus has eliminated incompetence after its seam contracting,
Retain valvular function as far as possible again.But this operation needs are begun to speak, operation wound is big.
The content of the invention
It is an object of the invention to provide a kind of heart valve annulus compression apparatus, and annulus wall is separately fixed at by two fixators
On, then shorten the surgical thread distance between fixator, realize the relative distance for reducing the back lobe annulus being connected with fixator so that
Annulus reduces, and is sutured without beginning to speak, operation wound is small.
In order to achieve the above object, the present invention provides following technical scheme:
Heart valve annulus compression apparatus, including syringe needle, conduit, seal wire and two fixators, the syringe needle are hollow structure, institute
Syringe needle connecting conduit is stated, a fixator is fixed on the distal end of surgical thread, and another fixator is flexibly connected with surgical thread, the seal wire
It is detachably connected with the fixator, the seal wire can promote the fixator to be moved in the conduit.Will by sheath
Conduit is delivered in intersection, promotes conduit, the syringe needle of catheter tip is inserted a certain position of back lobe annulus, is promoted seal wire,
The fixator of surgical thread distal end is passed out of conduit, be fixed on annulus wall;Conduit is retracted, the syringe needle of catheter tip is inserted
The another location of back lobe annulus, seal wire is promoted, another fixator in surgical thread is passed out of conduit, is fixed on annulus wall
On;Pull back surgical thread, make surgical thread from second fixator being fixed on annulus wall toward recovery, so as to solid by reducing two
Determine the distance between device, reduce the relative distance for the back lobe annulus being connected with fixator so that annulus reduces, and then makes bicuspid valve
Open area is reduced, so as to reduce reflux amount.
In a preferred embodiment, the fixator includes slide bar and rack, and the top of the rack is fixed on
On the slide bar, the end of the rack can be detachably connected along sliding bar, the end of the rack with the seal wire,
When rack is located in the conduit, the rack is into closure state, when rack is released by seal wire out of described conduit, institute
The end for stating rack slides into and is connected with the top of rack, and the rack is opened into umbrella.
In a preferred embodiment, the rack is made of memory metal.Memory metal has restoration, leads to
Cross memory metal material and make rack, it is umbrella to make its solid shape, to ensure that it can be fixed on annulus wall.
In a preferred embodiment, the distal end of the surgical thread passes through the slide bar of a fixator, and this is described
Fixator can be slided along the surgical thread, and the distal end of the surgical thread is fixedly connected with the slide bar of another fixator.
In a preferred embodiment, the seal wire includes axial filament and turn, the outside winding bullet of the axial filament
Spring coil, the rack can be penetrated in the turn when closing, and the end of the turn and the rack is detachably connected.
In a preferred embodiment, the outer surface covering hydrophilic coating of the turn.
In a preferred embodiment, one end of the turn is fixed by connecting filament and turn, the other end
Hook is set, and the end for hooking the rack, the hook connects rotating bar, described when the rotating bar rotates
Link up with and deviate from from the end of the rack.The rotation of rotating bar can control the rotation of hook, so as to realize hook and rack end
The connection or abjection at end.When hook is connected with rack end, promotes guide wire motion to drive fixator motion, be in fixator
Suitable position;Rotating bar is rotated, hook is deviate from rack end, rollback seal wire, deviates from the fixator in turn.This
When, the end of the rack of fixator slides into be connected with the top of rack, and rack is opened into umbrella from closure state.
In a preferred embodiment, it is described operation the tight device of wire fixing clip, the gripping mechanism include cylinder and
Multiple clamping sheets, one end of all clamping sheets are fixed on the surface of cylinder, and the other end is free end, and free end can activity extremely
The drum surface, the surgical thread pass through the cylinder and fixation, the free end of the clamping sheet close to the distal end of surgical thread,
The fixator that can be slided slides between the distal tip of surgical thread and the gripping mechanism.
Beneficial effects of the present invention are:
Conduit is delivered in intersection by sheath, conduit is promoted, the syringe needle of catheter tip is inserted back lobe annulus
A certain position, seal wire is promoted, the fixator of surgical thread distal end is passed out of conduit, is fixed on annulus wall;Conduit is retracted, will
The another location of the syringe needle insertion back lobe annulus of catheter tip, promotes seal wire, makes another fixator in surgical thread out of conduit
Pass, be fixed on annulus wall;Pull back surgical thread, make surgical thread from second fixator being fixed on annulus wall toward recovery,
So as to by reducing the distance between two fixators, reduce the relative distance for the back lobe annulus being connected with fixator so that valve
Ring reduces, and then reduces mitral valve orifice area, so as to reduce reflux amount.
Brief description of the drawings
In order to illustrate more clearly about the embodiment of the present invention or technical scheme of the prior art, below will be to embodiment or existing
There is the required accompanying drawing used in technology description to be briefly described, it should be apparent that, drawings in the following description are only this
Some embodiments of invention, for those of ordinary skill in the art, without having to pay creative labor, may be used also
To obtain other accompanying drawings according to these accompanying drawings.
Fig. 1 is the structural representation of one embodiment of the present invention;
Fig. 2 is the connection diagram of fixator and surgical thread;
Structural representation when Fig. 3 is fixator closure state;
Structural representation when Fig. 4 is fixator open mode;
Fig. 5 is the structural representation of seal wire;
Fig. 6 is the connection diagram of seal wire and fixator;
Fig. 7 is the top view at Fig. 6 A;
Fig. 8 is schematic diagram when hook breaks off relations with Dropbox;
Fig. 9 is the structural representation of gripping mechanism.
Embodiment
Below in conjunction with the accompanying drawing of the present invention, technical scheme is clearly and completely described, it is clear that institute
The embodiment of description is only part of the embodiment of the present invention, rather than whole embodiments.Based on the embodiment in the present invention,
The every other embodiment that those of ordinary skill in the art are obtained under the premise of creative work is not made, belongs to this hair
The scope of bright protection.
With reference to Fig. 1-2, a kind of heart valve annulus compression apparatus provided by the invention, including syringe needle 1, conduit 2, seal wire 3 and solid
Determine device 41,42.Syringe needle 1 is hollow structure, and the distal end of syringe needle 1 is into pin end, and near-end is fixedly connected with conduit 2.Surgical thread 5 is worn successively
Enter fixator 41,42, and fixator 41 is bundled in the distal end of surgical thread 5, fixator 42 can slide along surgical thread 5.Lead
Silk 3 can be detachably connected with fixator 41,42 respectively.Seal wire 3 is penetrated inside conduit 2 together with fixator 41,42.Entering
During row operation, syringe needle 1 and conduit 2 are delivered in intersection together by sheath, conduit 2 is promoted, syringe needle 1 is inserted back lobe valve
The a certain position of ring.Seal wire 3 is connected with fixator 41, is promoted seal wire 3, fixator 41 is passed by syringe needle 1, and fixator 41 is solid
It is scheduled on annulus wall;Conduit 2 is retracted, and syringe needle 1 is inserted to the another location of back lobe annulus, control seal wire 3 connects with fixator 42
Connect, promote seal wire 3 again, fixator 42 is passed by syringe needle 1, be fixed on annulus wall.Surgical thread 5 is work with fixator 42
Dynamic connection, by surgical thread 5 of pulling back, shorten fixator 41, the distance between 42, reduce the back lobe being connected with fixator 41,42
The relative distance of annulus so that annulus reduces, and then reduces mitral valve orifice area, so as to reduce reflux amount.
The structure of fixator 41,42 is the same, all including slide bar 404 and rack, such as Fig. 3-4.Rack uses memory metal, such as
Ti-Ni alloy is by being woven into grid 403.The top of grid 403 forms the top that a Dropbox 401 is fixed on slide bar 404, net
The end of lattice 403 forms a Dropbox 402.Slide bar 404 is penetrated in Dropbox 402, and Dropbox 402 can be slided along slide bar 404.When
When Dropbox 402 slides into 404 lower section of slide bar, grid 403 is fitted in the surface of slide bar 404, is closure state.Fixator 41,42
When in conduit 2, grid 403 is in closure state.When Dropbox 402 slides into 404 top of slide bar, Dropbox 402 slide into
Dropbox 401 connects, and grid opens to form umbrella from the surface of slide bar 404.
Such as Fig. 5-6, seal wire 3 includes axial filament 31 and turn 32.The top of axial filament 31 passes through connecting filament and turn 32
Top connects, and turn 32 is wrapped in the outside of axial filament 31.The outer surface covering hydrophilic coating of turn 32.Such as Fig. 7, spring
The end of circle 32 sets hook 7, the connection rotating bar 6 of hook 7.Rotating bar 6, which rotates, can drive hook 7 to rotate.The energy of turn 32
Enough close the grid 403 of closure surrounds.Hook 7 is set to hook Dropbox 402 by rotating bar 6.Axial filament 31 promotes fixator
41, to when needing fixed position, promote axial filament 31, fixator 41 is deviate from from conduit 2, are rotated further by rotating bar 6, hook 7 from
Deviate from Dropbox 402, such as Fig. 8, and retract axial filament 31.Due to the return action of memory metal, Dropbox 402 slides into and Dropbox
401 connections, grid open to form umbrella from the surface of slide bar 404.So that fixator 41 is fixed on annulus wall.
In order to prevent fixator 42 from voluntarily sliding into the near-end of surgical thread 5, in one embodiment, such as Fig. 9, in addition to
Gripping mechanism 8.Gripping mechanism 8 includes cylinder 81 and six clamping sheets 82.One end of all clamping sheets 82 is fixed on cylinder 81
Surface, the other end is free end, surface of the free end away from cylinder 81, makes six clamping sheets 82 into radial.Clamping sheet 82
Free end can be stressed to the surface of cylinder 81.Cylinder 81 is fixed in surgical thread 5, and the free end of clamping sheet 82 is close
The distal end of surgical thread 5.The slide bar 404 of fixator penetrates from the distal end of surgical thread 5, and it can slide into the freedom of clamping sheet 82
End.Because the free end of clamping sheet 82 is into radial, the diameter of slide bar 404 is smaller, can not deviate from from the free end of clamping sheet 82,
Fixator is set to be slided between the distal end of surgical thread and gripping mechanism 8.The slide bar 404 of fixator can also be from surgical thread 5
Near-end penetrate, now, the slide bar 404 of fixator is needed through gripping mechanism 8.Cylinder 81 is connected with the fixing end of clamping sheet 82
Diameter afterwards is less than the internal diameter of slide bar 404.Slide bar 404 can slide into the distal end of surgical thread 5 through gripping mechanism 8.Work as fixation
When device 41 slides into the distal end of surgical thread 5, the distal end of surgical thread 5 and the slide bar 404 of fixator 41 are consolidated by way of binding
It is fixed.After fixator 42 passes through the gripping mechanism 8 of surgical thread 5, it can not be slided from the free end of clamping sheet 82 to the near-end of surgical thread 5
It is dynamic, so as to limit the sliding position of fixator 42.
The foregoing is only a specific embodiment of the invention, but protection scope of the present invention is not limited thereto, any
Those familiar with the art the invention discloses technical scope in, change or replacement can be readily occurred in, should all be contained
Cover within protection scope of the present invention.Therefore, protection scope of the present invention should be defined by scope of the claims.
Claims (7)
1. heart valve annulus compression apparatus, it is characterised in that:Including syringe needle, conduit, seal wire and two fixators, during the syringe needle is
Hollow structure, the syringe needle connecting conduit, a fixator are fixed on the distal end of surgical thread, and another fixator connects with surgical thread activity
Connect, the seal wire is detachably connected with the fixator, and the seal wire can promote the fixator to be moved in the conduit;
The fixator includes slide bar and rack, and the top of the rack is fixed on the slide bar, the end energy of the rack
It is enough to be detachably connected along sliding bar, the end of the rack with the seal wire, it is described when rack is located in the conduit
Rack is into closure state, and when rack is released by seal wire out of described conduit, the end of the rack slides into and rack
Top connects, and the rack is opened into umbrella.
2. heart valve annulus compression apparatus according to claim 1, it is characterised in that the rack uses memory metal system
Into.
3. heart valve annulus compression apparatus according to claim 1 or 2, it is characterised in that the distal end of the surgical thread passes through
The slide bar of one fixator, the fixator can slide along the surgical thread, the distal end of the surgical thread with it is another
The slide bar of the fixator is fixedly connected.
4. heart valve annulus compression apparatus according to claim 3, it is characterised in that the seal wire includes axial filament and spring
Circle, the outside winding spring circle of the axial filament, the rack can be penetrated in the turn when closing, the turn and institute
The end for stating rack is detachably connected.
5. heart valve annulus compression apparatus according to claim 4, it is characterised in that the outer surface covering parent of the turn
Water coating.
6. heart valve annulus compression apparatus according to claim 4, it is characterised in that one end of the turn passes through connection
Silk is fixed with turn, and the other end sets hook, the end for hooking the rack, and the hook connects rotating bar,
When the rotating bar rotates, the hook is deviate from from the end of the rack.
7. heart valve annulus compression apparatus according to claim 3, it is characterised in that the operation tight device of wire fixing clip,
The gripping mechanism includes cylinder and multiple clamping sheets, and one end of all clamping sheets is fixed on the surface of cylinder, and the other end is certainly
By holding, and free end can activity pass through the cylinder and fixation to the drum surface, the surgical thread, the clamping sheet
Free end close to the distal end of surgical thread, the fixator that can be slided surgical thread distal tip and the gripping mechanism it
Between slide.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201610280415.8A CN105997304B (en) | 2016-04-29 | 2016-04-29 | Heart valve annulus compression apparatus |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201610280415.8A CN105997304B (en) | 2016-04-29 | 2016-04-29 | Heart valve annulus compression apparatus |
Publications (2)
Publication Number | Publication Date |
---|---|
CN105997304A CN105997304A (en) | 2016-10-12 |
CN105997304B true CN105997304B (en) | 2017-11-28 |
Family
ID=57082150
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN201610280415.8A Active CN105997304B (en) | 2016-04-29 | 2016-04-29 | Heart valve annulus compression apparatus |
Country Status (1)
Country | Link |
---|---|
CN (1) | CN105997304B (en) |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN107252327B (en) * | 2016-10-21 | 2020-05-22 | 塞佩赫·法里亚比 | Tissue attachment device for percutaneous treatment of mitral regurgitation |
CN106388880B (en) * | 2016-10-21 | 2019-06-14 | 武汉唯柯医疗科技有限公司 | A kind of annulus of mitral valve contracting intervention device |
EP3634255B1 (en) * | 2017-06-08 | 2020-08-12 | 4Tech Inc. | Tissue anchor with tether stop |
US10874388B2 (en) * | 2017-11-30 | 2020-12-29 | Boston Scientific Scimed, Inc. | Connected anchor delivery systems and methods for valve repair |
CN108904102B (en) * | 2018-07-19 | 2023-12-12 | 上海诺强医疗科技有限公司 | Transcatheter mitral valve systole system and method of use thereof |
WO2020134052A1 (en) * | 2018-12-29 | 2020-07-02 | 杭州德晋医疗科技有限公司 | Single window-guided valve annulus reduction system |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5944738A (en) * | 1998-02-06 | 1999-08-31 | Aga Medical Corporation | Percutaneous catheter directed constricting occlusion device |
US8956407B2 (en) * | 2000-09-20 | 2015-02-17 | Mvrx, Inc. | Methods for reshaping a heart valve annulus using a tensioning implant |
CN100594045C (en) * | 2005-11-09 | 2010-03-17 | 温宁 | Apparatus for delivering artificial heart stent valve |
WO2011003002A2 (en) * | 2009-07-02 | 2011-01-06 | Medicinelodge, Inc. Dba Imds Co-Innovation | Systems and methods for zipknot acl fixation |
SE535140C2 (en) * | 2010-03-25 | 2012-04-24 | Jan Otto Solem | An implantable device, kit and system for improving cardiac function, including means for generating longitudinal movement of the mitral valve |
EP2567663A1 (en) * | 2011-09-09 | 2013-03-13 | Occlutech Holding AG | A collapsible medical closing device, a method and a medical system for delivering an object |
WO2015058001A1 (en) * | 2013-10-17 | 2015-04-23 | Cedars-Sinai Medical Center | Device to percutaneously treat heart valve embolization |
US10166098B2 (en) * | 2013-10-25 | 2019-01-01 | Middle Peak Medical, Inc. | Systems and methods for transcatheter treatment of valve regurgitation |
-
2016
- 2016-04-29 CN CN201610280415.8A patent/CN105997304B/en active Active
Also Published As
Publication number | Publication date |
---|---|
CN105997304A (en) | 2016-10-12 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CN105997304B (en) | Heart valve annulus compression apparatus | |
US20240024103A1 (en) | Valve Prosthesis | |
JP6526000B2 (en) | Sealing devices, related delivery devices and their use | |
US20210369264A1 (en) | Surgical suturing device for a replacement anatomical structure and methods thereof | |
US20190388084A1 (en) | Suturing devices and methods for suturing an anatomic valve | |
US8778016B2 (en) | Method and apparatus for repairing or replacing chordae tendinae | |
CN108283534B (en) | Bicuspid valve parking device and system | |
CN102131479B (en) | Cardiac valve downsizing device and method | |
EP3342355A1 (en) | Medical securing device for securing an object with a securing member | |
US11160549B2 (en) | Medical securing device for securing an object with a securing member | |
CN108463188A (en) | Multilayer cardiac implant | |
CN110114037A (en) | The stent graft delivery system of radially adjustable | |
CN112168427A (en) | Heart apex implantation cusp clamping device and heart apex implantation cusp clamping method | |
CN102858277A (en) | Catheter assembly with valve crimping accessories | |
CN107252327A (en) | Tissue attaching device for transdermal therapeutic mitral reflux | |
WO2020114299A1 (en) | Stent valve prosthesis and delivery system thereof | |
CN110167482A (en) | The systems, devices and methods for being used to fetch system with tether | |
CN109843185A (en) | Heart valve regurgitation anchoring piece and means of delivery | |
US20210161523A1 (en) | Medical securing device for securing an object with a securing member | |
CN207071110U (en) | Intraluminal stent and its induction system | |
CN113576567A (en) | Puncture needle with thread and suture knot | |
CN218922887U (en) | Valve forming device | |
CN216777297U (en) | Mitral valve stent | |
CN212466264U (en) | Needle inserting system with positioning function | |
WO2024051051A1 (en) | Apparatus and method for treating native valve leaflets in human heart |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
C06 | Publication | ||
PB01 | Publication | ||
C10 | Entry into substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
GR01 | Patent grant | ||
GR01 | Patent grant | ||
TR01 | Transfer of patent right | ||
TR01 | Transfer of patent right |
Effective date of registration: 20180810 Address after: 430070 202 building, No. 2, No. 2, B9 building, 818 hi-tech Avenue, East Lake New Technology Development Zone, Wuhan, Hubei. Patentee after: Wuhan Wei Ke Medical Technology Co., Ltd. Address before: 430079 Hongshan District, Wuhan, Hubei, 4 buildings, 1 units, 1101 rooms. Patentee before: Xiao Shuna |