CN105962237A - Royal jelly-propolis-momordica charantia lozenges and preparation method thereof - Google Patents
Royal jelly-propolis-momordica charantia lozenges and preparation method thereof Download PDFInfo
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- CN105962237A CN105962237A CN201610299100.8A CN201610299100A CN105962237A CN 105962237 A CN105962237 A CN 105962237A CN 201610299100 A CN201610299100 A CN 201610299100A CN 105962237 A CN105962237 A CN 105962237A
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Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
Landscapes
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
The invention discloses royal jelly-propolis-momordica charantia lozenges. The royal jelly-propolis-momordica charantia lozenges are composed of main materials and auxiliary materials; the main materials comprise the following raw materials in parts by weight: 40-80 parts of dry royal jelly powder, 10-40 parts of propolis powder, 5-20 parts of momordica charantia extract powder, 4-18 parts of dry mint powder, 5-15 parts of dry luffa powder, 5-13 parts of dry cucumber powder, 3-8 parts of dry aloe powder, 2-5 parts of dry lemon powder, 1-3 parts of dry willow Leaf powder, 1-2.5 parts of dry dandelion powder, 0.5-1.5 parts of dry poria coco powder and 1-2 parts of spirulina powder; and the auxiliary materials comprise the following raw materials in parts by weight: 5-20 parts of magnesium stearate and 3-5 parts of microcrystalline cellulose. The invention further discloses a preparation method of the royal jelly-propolis-momordica charantia lozenges. The royal jelly-propolis-momordica charantia lozenges are capable of effectively reducing blood glucose and blood lipid, and are easy to carry and convenient to use.
Description
Technical field
The present invention relates to buccal tablet, particularly a kind of Lac regis apis bee glue bitter gourd buccal tablet, the present invention also relates to
And the preparation method of this Lac regis apis bee glue bitter gourd buccal tablet.
Background technology
Lac regis apis is the bee product that a class component is considerably complicated, it along with bee species, the age,
Season, the difference of pollen plant, its chemical analysis is the most different.In general, its composition
For: moisture content 64.5～69.5%, crude protein 11～14.5%, carbohydrate 13～15%,
Lipid 6.0%, mineral 0.4～2% its protein account for the 50% of Lac regis apis dry, its
In have 2/3 for albumin, 1/3 is globulin, and the protein in Lac regis apis has more than 12 kinds,
In addition with many small peptides.Its aminoacid accounts for the 1.8% of Lac regis apis dry weight, institute in human body
The 8 kinds of essential amino acids needed, have existence in Lac regis apis, and wherein proline content is the highest
Account for 63%, in Lac regis apis, found 20 kinds of aminoacid at present.Lac regis apis contains nucleic acid,
Wherein the content of DNA (deoxyribonucleic acid) (DNA) is the aobvious weights of 201～223 micro-gram gram, ribose core
The content of acid is the aobvious weights of 3.9～4.9 milligrams per gram.Containing 20～30% (dry weight) in Lac regis apis
Saccharide, the most substantially containing fructose 52%, glucose 45%, sucrose 1%, maltose 1%,
Radix Gentianae two pool 1%.It is the richest that Lac regis apis contains more vitamin, especially vitamin B group
Richness, remaining mainly has thiamine (B1), riboflavin (B2), pyridoxol (B6), vitamin
(B12), nicotinic acid, pantothenic acid, folic acid, biotin, inositol, vitamin C, vitamin D
Deng, wherein pantothenic acid content is the highest.Lac regis apis contains the fatty acid of more than 26 kinds, the most by
Identify have 12 kinds, they be 10-HAD (10-HDA), capric acid,
N-nonanoic acid, hendecanoic acid, dodecylic acid, tetradecanoic acid (myristic acid), myristoleic acid,
Hexadecanoic acid (Palmic acid), octadecanoid acid, palmitoleic acid, arachidic acid and linoleic acid etc., its
Middle 10-hydroxyl-2-certain herbaceous plants with big flowers olefin(e) acid, content is more than 1.4%, owing to only having honeybee in nature
Containing this material in royal jelly, so also it being referred to as Royal Jelly acid.Lac regis apis contains 9 kinds admittedly
Alcohol compound, the most identified go out three kinds, they are stigmasterol, cholesterol and sitoesterol.
Additionally possibly together with mineral, ferrum, copper, magnesium, zinc, potassium, sodium etc..
Lac regis apis has following effect: 1) Lac regis apis is containing acetylcholine, and vegetative nerve can be made extensive
Multiple normal, notable to treatment cardiovascular diseases's effect；2) Lac regis apis is rich in vitamin B and high-quality
Protein, particularly containing the royal jelly acid that sterilizing power is strong, thus is good medicine for cancer；3) Lac regis apis
There is promotion hemopoietic function effect, developmental children can be increased hemoglobin, promote raw
Long, improve premunition；4) Lac regis apis is contained within pantothenic acid, can improve rheumatism and joint symptoms；
5) Lac regis apis contains para-insulin, and diabetes are had better effects；6) Lac regis apis can be strengthened on kidney
Gland cortex function, regulates human hormone, brain cell between activation, is conducive to treatment climacteric obstacle
Disease and chronic prostatitis syndrome；7) Lac regis apis can strengthen the basis muscle power of people, makes human senility
Tissue activation, after clothes, appetite is good, and long spirit, complexion is good；8) peptide contained by Lac regis apis and albumen
Matter class healthy ingredient, can promote intelligent development, thus take and can improve memory；9) queen bee
Slurry is containing proteohormone, with blood circulation whole body after clothes, contributes to skin histology technical ability and recovers to live
Power, scalds effect to treatment obvious；10) Lac regis apis contains plurality of inorganic salt, can promote that glycogen is released
Put, promote metabolism, thus can improve looks, eliminate speckle.But, Lac regis apis is to thermoae shakiness
Fixed, to place one day at normal temperatures, freshness is decreased obviously, about 130 DEG C inefficacies.But
Under low temperature the most stable, can preserve 1 year at subzero 2 DEG C, the several years can be preserved at subzero 18 DEG C constant.
Lac regis apis exposes in atmosphere, can play oxidation, hydrolysis, and light has catalytic action to Lac regis apis,
Its aldehyde radical, ketone group are played reduction.
Propolis contains abundant nutritional labeling, containing the flavonoid of more than 70 kinds in propolis
Thing, chromocor compound includes flavonoid, flavonols and Flavanones etc., accounts for propolis
4.13%, and 5,7-dihydroxy-3,4-dimethyl flavone and 5-hydroxyl-4,7-diformazan
Epoxide flavanone is the distinctive effective ingredient of propolis in nature, and Cortex querci dentatae have the crown blood of expansion
Guan, reduce the effect such as blood fat, blood pressure lowering, antiplatelet aggregation, rutin (Rutin) is exactly
Globulariacitrin, has the effect that vitamin is same；Propolis has multiple alkene, terpenoid, has
Antibacterial and tumor-suppression activity；In propolis containing the aminoacid of trace, the vitamin B complex of trace,
Abundant minerals and vitamins, multiple organic acid；Acid compounds contained in propolis has
Caffeic acid, anisic acid, P-coumaric acid, ferulic acid, Hesperetic acid, cinnamic acid, 3,4-bis-
Methoxyl group cinnamic acid, benzoic acid, P-hydroxybenzoic acid etc..Propolis has following effect: 1)
Broad-spectrum antibacterial action: propolis can suppress the growth of various bacteria and some virus, has wide spectrum and resists
Raw element effect.Propolis ethanol soluble extraction 100 mcg/ml concentration is to 25 in 39 kinds of antibacterials
Plant and have inhibitory action with 20 kinds in 39 kinds of plant epiphytes, especially thin to Gram-positive
Bacterium and acid fast bacteria are most sensitive.The propolis alcohol of 1%～10% or ether extract are common to the mankind
Fungus, bacterium, cotton-shaped bacterium, red bacterium, Microsporum ferrugineum, Gypsum Fibrosum sample sporidiole
Bacterium, microsporum canis, brain shape bacterium, Gypsum Fibrosum sample bacterium, disconnected bacterium, purple
Bacterium etc. have inhibitory action.To cucumber mosaic virus, tobacco mottle virus, tobacco necrosis virus
Preferable killing action is had with influenza A.The breeding of herpesvirus can be suppressed with notable
Alleviate the infection of vaccinia virus；Trichomonal vaginitis there is killing action；To diphtheria corynebacterium, broken wound
Wind bacterium and bacillus oedematis extracellular toxin have neutralization., share with some antibiotics meanwhile, can carry
High antibacterial activity and its effect of prolongation.2) body's immunity is promoted: coordinate antigen with propolis
Inject in white mice, rat, Cavia porcellus, home mouse, pig and calf body, exempting from of body can be promoted
Epidemic disease process.To stot injection paratyphoid fever vaccine while domestic propolis, can immune stimulatory function,
Stimulate the synthesis of H-agglutinin and the proliferative effect of O-collection element, increase antibody production and increase huge biting
The vigor of cell.3) tissue regeneration is promoted: zoopery shows, with propolis Experiment on therapy
Deep burn, more general pharmaceutical treatment healing time is short, good effect.Propolis can accelerate to be damaged
The cartilage of wound and the regenerative process of bone, have stimulation regeneration to pulp injury, promotes circulation barrier
The recovery hindered, stimulates dental pulp hose lining thick fiber bridge to be formed.
Fructus Momordicae charantiae has following effect: 1) heat clearing away QI invigorating: Fructus Momordicae charantiae has clearing away heat and removing summer, nourish blood benefit
Gas, kidney and spleen invigorating, effect of nourishing liver for improving eyesight, heatstroke heating swollen to treatment dysentery, skin ulcer, miliaria
The diseases such as son is too much, conjunctivitis have certain effect.2) protection body: it is bad that Fructus Momordicae charantiae has prevention
Disorders of blood, protection cell membrane, atherosclerosis, raising physical stress ability, the protection heart
Dirty grade acts on.3) anticancer: the effective ingredient in Fructus Momordicae charantiae can suppress Normocellular canceration and
Promote the recovery of mutant cell, there is certain antitumaous effect.4) blood sugar lowering, blood fat reducing:
Have blood sugar lowering, blood fat reducing, antitumor, pre-preventing bone rarefaction, endocrine regulation, antioxidation,
Antibacterial and improve the medicinal and health care such as body immunity.5) beauty treatment skin: Fructus Momordicae charantiae energy
Moisten fair skin, moreover it is possible to calm and moisturizing skin, particularly in the most scorching summer, apply
The Fructus Momordicae charantiae slice that upper ice is crossed, can release the agitation of skin immediately.
At present, it is not the most that raw material preparation produces into the product of buccal tablet by these three material.
Summary of the invention
The first object of the present invention is to overcome the weak point of above-mentioned existing background technology, and carries
For a kind of Lac regis apis bee glue bitter gourd buccal tablet.
The second object of the present invention is to provide the preparation side of this Lac regis apis bee glue bitter gourd buccal tablet
Method.
The first object of the present invention is reached by following measure: Lac regis apis bee glue bitter gourd contains
Sheet, is made up of main material and auxiliary material, described main material by 40～80 parts of Lac regis apis dry powders,
The propolis powder of 10～40 weight portions, 5～20 parts of Fructus Momordicae charantiae extract powder, 4～18 weight portion thin
Lotus dry powder, 5～15 Fructus Luffae dry powder, 5～13 Fructus Cucumidis sativi dry powder, 3～8 of weight portion of weight portion
The Aloe dry powder of weight portion, 2～5 Fructus Citri Limoniae dry powder, 1～3 Folium Pterocaryaes of weight portion of weight portion
Dry powder, 1～2.5 weight portion Herba Taraxaci dry powder, 0.5～1.5 weight portion Poria dry powder, 1～2
Weight portion Spirulina powder composition, described auxiliary material by 5～20 weight portion magnesium stearate, 3～5
The microcrystalline Cellulose composition of weight portion.
Preferably, main material is by 50～70 parts of Lac regis apis dry powders, 20～30 propolis of weight portion
Powder, 10～15 parts of Fructus Momordicae charantiae extract powder, 6～15 Herba Menthae dry powder, 8～12 weight of weight portion
Part Fructus Luffae dry powder, 8～12 weight portion Fructus Cucumidis sativi dry powder, 5～7 weight portion Aloe dry powder,
The Fructus Citri Limoniae dry powder of 3～4 weight portions, 2～3 Folium Pterocaryae dry powder, 1.5～2 weight portions of weight portion
Herba Taraxaci dry powder, 1～1.2 weight portion Poria dry powder, 1.2～1.8 Spirulina powder of weight portion
Composition, described auxiliary material is by 8～15 weight portion magnesium stearate, 3.5～4.5 crystallites of weight portion
Cellulose forms.
Further, main material by 60 parts of Lac regis apis dry powders, the propolis powder of 25 weight portions, 12
Part Fructus Momordicae charantiae extract powder, the Herba Menthae dry powder of 10 weight portions, the Fructus Luffae dry powder of 10 weight portions, 10
The Fructus Cucumidis sativi dry powder of weight portion, the Aloe dry powder of 6 weight portions, the Fructus Citri Limoniae dry powder of 3.5 weight portions,
The Folium Pterocaryae dry powder of 2.5 weight portions, the Herba Taraxaci dry powder of 1.8 weight portions, 1.1 weight portion Poria
Dry powder, 1.5 weight portions Spirulina powder composition, described auxiliary material by 12 weight portion magnesium stearate,
The microcrystalline Cellulose composition of 4 weight portions.
The second object of the present invention is reached by following measure: prepare Lac regis apis propolis bitter
The method of melon buccal tablet, comprises the steps:
1) by Lac regis apis microwave vacuum drying at 80 DEG C, pulverize, cross 80 mesh sieves, obtain
Lac regis apis dry powder；
2) propolis is pulverized, cross 80 mesh sieves, obtain propolis powder；
3) fresh Fructus Momordicae charantiae organic solvent is extracted at 55 DEG C, by extracting solution Rotary Evaporators
Evaporation, is dried to obtain Fructus Momordicae charantiae extract powder；
4) fresh Fructus Luffae, fresh Aloe, lemon, fresh cucumbers, Poria is dry at 80 DEG C respectively
Dry 24～32h, pulverize, cross 30 mesh sieves, obtain Fructus Luffae dry powder, Aloe dry powder, Fructus Citri Limoniae dry powder,
Fructus Cucumidis sativi dry powder, Poria dry powder；
5) Herba Menthae, Folium Pterocaryae, Herba Taraxaci are dried at 60 DEG C 8～12h, pulverize, cross 30
Mesh sieve, obtains Herba Menthae dry powder, Folium Pterocaryae dry powder, Herba Taraxaci dry powder；
6) by above-mentioned parts by weight by Spirulina powder, step 1) Lac regis apis dry powder of gained,
Step 2) propolis powder of gained, step 3) the Fructus Momordicae charantiae extract powder of gained, step 4) institute
Fructus Luffae dry powder, Aloe dry powder, Fructus Citri Limoniae dry powder, Fructus Cucumidis sativi dry powder, Poria dry powder, step 5)
The Herba Menthae dry powder of gained, Folium Pterocaryae dry powder, Herba Taraxaci dry powder blend are uniform, obtain main material；
7) meter weighs magnesium stearate, microcrystalline Cellulose, mix homogeneously by weight, obtains
Auxiliary material；
8) main material is mixed homogeneously with auxiliary material, tabletting, obtain Lac regis apis bee glue bitter gourd and contain
Sheet.
Preferably, step 3) in, organic solvent is dehydrated alcohol and glycerol is by volume
The mixed solvent of 30～50: 1 compositions.
Further, organic solvent is dehydrated alcohol and glycerol is 40～48: 1 groups by volume
The mixed solvent become.
Further, organic solvent is dehydrated alcohol and glycerol is 46: 1 compositions by volume
Mixed solvent.
It is an advantage of the current invention that:
One, the moisture in the instantaneous dry Lac regis apis of microwave vacuum drying energy low temperature of the present invention,
The active substance retained in Lac regis apis of limits, drying effect is good, and energy consumption is low, easy and simple to handle.
Its two, Lac regis apis bee glue bitter gourd buccal tablet of the present invention can strengthening immune system, strengthen immunity
Cell viability, the specificity of regulation body and non-specific immunity.
Its three, Lac regis apis bee glue bitter gourd of the present invention contains chromocor compound, Charantin, similar pancreas
The materials such as island element can effectively reduce blood pressure and blood lipoid.
Its four, the contour biological active matter of Royal Jelly acid that Lac regis apis bee glue bitter gourd buccal tablet of the present invention has
Matter, can make protein helical structure and aminoacid sequence by stimulating the synthesis of cyclic phosphate glycoside
Normalization, thus have inhibitory action to cancerous cell, can alleviate chemotherapy, pair that radiotherapy causes simultaneously
Effect.
Five, present invention preserves the effective ingredient of Lac regis apis bee glue bitter gourd extract, Ke Yiti
High immunity, reduction blood pressure and blood lipoid, and be easy to carry, instant.
Detailed description of the invention
Below in conjunction with embodiment describe in detail the present invention performance, but they be not intended that right
The restriction of the present invention, the most for example.To be become more by explanation advantages of the present invention simultaneously
Add clear and easy to understand.
Lac regis apis bee glue bitter gourd buccal tablet, is made up of main material and auxiliary material, described main material by
40～80 parts of Lac regis apis dry powders, 10～40 propolis powder of weight portion, 5～20 portions of Fructus Momordicae charantiaes extract
Thing powder, 4～18 Herba Menthae dry powder, 5～15 Fructus Luffae dry powder, 5～13 of weight portion of weight portion
The Fructus Cucumidis sativi dry powder of weight portion, 3～8 weight portion Aloe dry powder, 2～5 weight portion Fructus Citri Limoniae do
Powder, 1～3 weight portion Folium Pterocaryae dry powder, 1～2.5 weight portion Herba Taraxaci dry powder, 0.5～
1.5 weight portion Poria dry powder, 1～2 Spirulina powder compositions of weight portion, described auxiliary material by 5～
20 weight portion magnesium stearate, 3～5 weight portion microcrystalline Cellulose composition.
Preferably, main material is by 50～70 parts of Lac regis apis dry powders, 20～30 propolis of weight portion
Powder, 10～15 parts of Fructus Momordicae charantiae extract powder, 6～15 Herba Menthae dry powder, 8～12 weight of weight portion
Part Fructus Luffae dry powder, 8～12 weight portion Fructus Cucumidis sativi dry powder, 5～7 weight portion Aloe dry powder,
The Fructus Citri Limoniae dry powder of 3～4 weight portions, 2～3 Folium Pterocaryae dry powder, 1.5～2 weight portions of weight portion
Herba Taraxaci dry powder, 1～1.2 weight portion Poria dry powder, 1.2～1.8 Spirulina powder of weight portion
Composition, described auxiliary material is by 8～15 weight portion magnesium stearate, 3.5～4.5 crystallites of weight portion
Cellulose forms.
Further, main material by 60 parts of Lac regis apis dry powders, the propolis powder of 25 weight portions, 12
Part Fructus Momordicae charantiae extract powder, the Herba Menthae dry powder of 10 weight portions, the Fructus Luffae dry powder of 10 weight portions, 10
The Fructus Cucumidis sativi dry powder of weight portion, the Aloe dry powder of 6 weight portions, the Fructus Citri Limoniae dry powder of 3.5 weight portions,
The Folium Pterocaryae dry powder of 2.5 weight portions, the Herba Taraxaci dry powder of 1.8 weight portions, 1.1 weight portion Poria
Dry powder, 1.5 weight portions Spirulina powder composition, described auxiliary material by 12 weight portion magnesium stearate,
The microcrystalline Cellulose composition of 4 weight portions.
The second object of the present invention is reached by following measure: prepare Lac regis apis propolis bitter
The method of melon buccal tablet, comprises the steps:
1) by Lac regis apis microwave vacuum drying at 80 DEG C, pulverize, cross 80 mesh sieves, obtain
Lac regis apis dry powder；
2) propolis is pulverized, cross 80 mesh sieves, obtain propolis powder；
3) fresh Fructus Momordicae charantiae organic solvent is extracted at 55 DEG C, by extracting solution Rotary Evaporators
Evaporation, is dried to obtain Fructus Momordicae charantiae extract powder；
4) fresh Fructus Luffae, fresh Aloe, lemon, fresh cucumbers, Poria is dry at 80 DEG C respectively
Dry 24～32h, pulverize, cross 30 mesh sieves, obtain Fructus Luffae dry powder, Aloe dry powder, Fructus Citri Limoniae dry powder,
Fructus Cucumidis sativi dry powder, Poria dry powder；
5) Herba Menthae, Folium Pterocaryae, Herba Taraxaci are dried at 60 DEG C 8～12h, pulverize, cross 30
Mesh sieve, obtains Herba Menthae dry powder, Folium Pterocaryae dry powder, Herba Taraxaci dry powder；
6) by above-mentioned parts by weight by Spirulina powder, step 1) Lac regis apis dry powder of gained,
Step 2) propolis powder of gained, step 3) the Fructus Momordicae charantiae extract powder of gained, step 4) institute
Fructus Luffae dry powder, Aloe dry powder, Fructus Citri Limoniae dry powder, Fructus Cucumidis sativi dry powder, Poria dry powder, step 5)
The Herba Menthae dry powder of gained, Folium Pterocaryae dry powder, Herba Taraxaci dry powder blend are uniform, obtain main material；
7) meter weighs magnesium stearate, microcrystalline Cellulose, mix homogeneously by weight, obtains
Auxiliary material；
8) main material is mixed homogeneously with auxiliary material, tabletting, obtain Lac regis apis bee glue bitter gourd and contain
Sheet.
Preferably, step 3) in, organic solvent is dehydrated alcohol and glycerol is by volume
The mixed solvent of 30～50: 1 compositions.
Further, organic solvent is dehydrated alcohol and glycerol is 40～48: 1 groups by volume
The mixed solvent become.
Further, organic solvent is dehydrated alcohol and glycerol is 46: 1 compositions by volume
Mixed solvent.
Embodiment 1
Lac regis apis bee glue bitter gourd buccal tablet, is made up of main material and auxiliary material, and main material is by 60 parts
Lac regis apis dry powder, the propolis powder of 25 weight portions, 12 parts of Fructus Momordicae charantiae extract powder, 10 weight portions
Herba Menthae dry powder, the Fructus Luffae dry powder of 10 weight portions, the Fructus Cucumidis sativi dry powder of 10 weight portions, 6 weight portions
Aloe dry powder, the Fructus Citri Limoniae dry powder of 3.5 weight portions, the Folium Pterocaryae dry powder of 2.5 weight portions, 1.8
The Herba Taraxaci dry powder of weight portion, 1.1 weight portion Poria dry powder, the Spirulina powder group of 1.5 weight portions
Becoming, described auxiliary material is made up of 12 weight portion magnesium stearate, the microcrystalline Cellulose of 4 weight portions.
The method preparing Lac regis apis bee glue bitter gourd buccal tablet, comprises the steps:
1) by Lac regis apis microwave vacuum drying at 80 DEG C, pulverize, cross 80 mesh sieves, obtain
Lac regis apis dry powder；
2) propolis is pulverized, cross 80 mesh sieves, obtain propolis powder；
3) fresh Fructus Momordicae charantiae organic solvent is extracted at 55 DEG C, by extracting solution Rotary Evaporators
Evaporation, is dried to obtain Fructus Momordicae charantiae extract powder；Organic solvent be dehydrated alcohol and glycerol by volume
It it is the mixed solvent of 46: 1 compositions；
4) fresh Fructus Luffae, fresh Aloe, lemon, fresh cucumbers, Poria is dry at 80 DEG C respectively
Dry 30h, pulverize, cross 30 mesh sieves, obtain Fructus Luffae dry powder, Aloe dry powder, Fructus Citri Limoniae dry powder,
Fructus Cucumidis sativi dry powder, Poria dry powder；
5) Herba Menthae, Folium Pterocaryae, Herba Taraxaci are dried at 60 DEG C 10h, pulverize, cross 30 mesh
Sieve, obtains Herba Menthae dry powder, Folium Pterocaryae dry powder, Herba Taraxaci dry powder；
6) by above-mentioned parts by weight by Spirulina powder, step 1) Lac regis apis dry powder of gained,
Step 2) propolis powder of gained, step 3) the Fructus Momordicae charantiae extract powder of gained, step 4) institute
Fructus Luffae dry powder, Aloe dry powder, Fructus Citri Limoniae dry powder, Fructus Cucumidis sativi dry powder, Poria dry powder, step 5)
The Herba Menthae dry powder of gained, Folium Pterocaryae dry powder, Herba Taraxaci dry powder blend are uniform, obtain main material；
7) meter weighs magnesium stearate, microcrystalline Cellulose, mix homogeneously by weight, obtains
Auxiliary material；
8) main material is mixed homogeneously with auxiliary material, tabletting, obtain Lac regis apis bee glue bitter gourd and contain
Sheet.
Embodiment 2
Lac regis apis bee glue bitter gourd buccal tablet, is made up of main material and auxiliary material, and main material is by 50 parts
Lac regis apis dry powder, the propolis powder of 20 weight portions, 15 parts of Fructus Momordicae charantiae extract powder, 18 weight portions
Herba Menthae dry powder, the Fructus Luffae dry powder of 15 weight portions, the Fructus Cucumidis sativi dry powder of 13 weight portions, 8 weight portions
Aloe dry powder, the Fructus Citri Limoniae dry powder of 5 weight portions, the Folium Pterocaryae dry powder of 2 weight portions, 1.5 weight
The Herba Taraxaci dry powder of part, 1 weight portion Poria dry powder, the Spirulina powder composition of 1.8 weight portions,
Described auxiliary material is made up of 20 weight portion magnesium stearate, the microcrystalline Cellulose of 3.5 weight portions.
The method preparing Lac regis apis bee glue bitter gourd buccal tablet, step 3) in, organic solvent is anhydrous
Ethanol and glycerol are the mixed solvent of 48: 1 compositions by volume；Step 4) in, when being dried
Between be 24h；Step 5) in, drying time is 8h；Other parameters and preparation method are as implemented
Example 1.
Embodiment 3
Lac regis apis bee glue bitter gourd buccal tablet, is made up of main material and auxiliary material, and main material is by 80 parts
Lac regis apis dry powder, the propolis powder of 10 weight portions, 20 parts of Fructus Momordicae charantiae extract powder, 6 weight portions
Herba Menthae dry powder, the Fructus Luffae dry powder of 8 weight portions, the Fructus Cucumidis sativi dry powder of 8 weight portions, 5 weight portions
Aloe dry powder, the Fructus Citri Limoniae dry powder of 3 weight portions, the Folium Pterocaryae dry powder of 3 weight portions, 2.5 weight portions
Herba Taraxaci dry powder, 1.5 weight portion Poria dry powder, 2 weight portions Spirulina powder composition, institute
State auxiliary material to be made up of 8 weight portion magnesium stearate, the microcrystalline Cellulose of 5 weight portions.
The method preparing Lac regis apis bee glue bitter gourd buccal tablet, step 3) in, organic solvent is anhydrous
Ethanol and glycerol are the mixed solvent of 50: 1 compositions by volume；Step 4) in, when being dried
Between be 32h；Step 5) in, drying time is 12h；Other parameters are with preparation method strictly according to the facts
Execute example 1.
Embodiment 4
Lac regis apis bee glue bitter gourd buccal tablet, is made up of main material and auxiliary material, and main material is by 40 parts
Lac regis apis dry powder, the propolis powder of 30 weight portions, 5 parts of Fructus Momordicae charantiae extract powder, 4 weight portions thin
Lotus dry powder, the Fructus Luffae dry powder of 5 weight portions, the Fructus Cucumidis sativi dry powder of 12 weight portions, the reed of 3 weight portions
Luxuriant growth dry powder, the Fructus Citri Limoniae dry powder of 2 weight portions, the Folium Pterocaryae dry powder of 1.5 weight portions, 1 weight portion
Herba Taraxaci dry powder, 1.2 weight portion Poria dry powder, the Spirulina powder composition of 1 weight portion, described
Auxiliary material is made up of 5 weight portion magnesium stearate, the microcrystalline Cellulose of 3 weight portions.
The method preparing Lac regis apis bee glue bitter gourd buccal tablet, step 3) in, organic solvent is anhydrous
Ethanol and glycerol are the mixed solvent of 30: 1 compositions by volume；Step 4) in, when being dried
Between be 28h；Step 5) in, drying time is 9h；Other parameters and preparation method are as implemented
Example 1.
Embodiment 5
Lac regis apis bee glue bitter gourd buccal tablet, is made up of main material and auxiliary material, and main material is by 70 parts
Lac regis apis dry powder, the propolis powder of 40 weight portions, 10 parts of Fructus Momordicae charantiae extract powder, 15 weight portions
Herba Menthae dry powder, the Fructus Luffae dry powder of 12 weight portions, the Fructus Cucumidis sativi dry powder of 5 weight portions, 7 weight portions
Aloe dry powder, the Fructus Citri Limoniae dry powder of 4 weight portions, the Folium Pterocaryae dry powder of 1 weight portion, 2 weight portions
Herba Taraxaci dry powder, 0.5 weight portion Poria dry powder, 1.2 weight portions Spirulina powder composition, institute
State auxiliary material to be made up of 15 weight portion magnesium stearate, the microcrystalline Cellulose of 4.5 weight portions.
The method preparing Lac regis apis bee glue bitter gourd buccal tablet, step 3) in, organic solvent is anhydrous
Ethanol and glycerol are the mixed solvent of 40: 1 compositions by volume；Step 4) in, when being dried
Between be 25h；Step 5) in, drying time is 11h；Other parameters are with preparation method strictly according to the facts
Execute example 1.
Comparative example 1
Lac regis apis bee glue bitter gourd buccal tablet, is made up of main material and auxiliary material, and main material is by 118.4
Part Lac regis apis dry powder, the propolis powder composition of 25 weight portions, described auxiliary material is hard by 12 weight portions
Fatty acid magnesium, the microcrystalline Cellulose composition of 4 weight portions.
The method preparing Lac regis apis bee glue bitter gourd buccal tablet, comprises the steps:
1) by Lac regis apis microwave vacuum drying at 80 DEG C, pulverize, cross 80 mesh sieves, obtain
Lac regis apis dry powder；
2) propolis is pulverized, cross 80 mesh sieves, obtain propolis powder；
3) by weight by step 1) Lac regis apis dry powder of gained, step 2) honeybee of gained
Rubber powder mix homogeneously, obtains main material；
4) meter weighs magnesium stearate, microcrystalline Cellulose, mix homogeneously by weight, obtains
Auxiliary material；
5) main material is mixed homogeneously with auxiliary material, tabletting, obtain Lac regis apis bee glue bitter gourd and contain
Sheet.
Comparative example 2
Lac regis apis bee glue bitter gourd buccal tablet, is made up of main material and auxiliary material, and main material is by 111.5
Part Lac regis apis dry powder, the propolis powder of 25 weight portions, 12 parts of Fructus Momordicae charantiae extract powder, 10 weight portions
Herba Menthae dry powder, the Fructus Luffae dry powder of 10 weight portions, the Fructus Cucumidis sativi dry powder of 10 weight portions, 6 weight
The Aloe dry powder of part, the Fructus Citri Limoniae dry powder composition of 3.5 weight portions, described auxiliary material is by 12 weight portions
Magnesium stearate, the microcrystalline Cellulose composition of 4 weight portions.
The method preparing Lac regis apis bee glue bitter gourd buccal tablet, comprises the steps:
1) by Lac regis apis microwave vacuum drying at 80 DEG C, pulverize, cross 80 mesh sieves, obtain
Lac regis apis dry powder；
2) propolis is pulverized, cross 80 mesh sieves, obtain propolis powder；
3) fresh Fructus Momordicae charantiae organic solvent is extracted at 55 DEG C, by extracting solution Rotary Evaporators
Evaporation, is dried to obtain Fructus Momordicae charantiae extract powder；Organic solvent be dehydrated alcohol and glycerol by volume
It it is the mixed solvent of 46: 1 compositions；
4) fresh Fructus Luffae, fresh Aloe, lemon, fresh cucumbers are dried respectively at 80 DEG C 30h,
Pulverize, cross 30 mesh sieves, obtain Fructus Luffae dry powder, Aloe dry powder, Fructus Citri Limoniae dry powder, Fructus Cucumidis sativi dry powder；
5) Herba Menthae is dried at 60 DEG C 10h, pulverizes, cross 30 mesh sieves, obtain Herba Menthae dry powder；
6) by above-mentioned parts by weight by step 1) Lac regis apis dry powder of gained, step 2) gained
Propolis powder, step 3) the Fructus Momordicae charantiae extract powder of gained, step 4) gained Fructus Luffae dry powder,
Aloe dry powder, Fructus Citri Limoniae dry powder, Fructus Cucumidis sativi dry powder, step 5) the Herba Menthae dry powder blend of gained is uniform,
Obtain main material；
7) meter weighs magnesium stearate, microcrystalline Cellulose, mix homogeneously by weight, obtains
Auxiliary material；
8) main material is mixed homogeneously with auxiliary material, tabletting, obtain Lac regis apis bee glue bitter gourd and contain
Sheet.
Effect test
Illustrate that Lac regis apis bee glue bitter gourd buccal tablet of the present invention is at regulation height below by contrast test
Effectiveness comparison in terms of blood glucose, hyperlipidemia, cholesterol: wherein T-CHOL TCHO is normal
Value: 3.0～5.7mmol/L；Triglyceride TG normal value: 0.5～1.7mmol/L；Blood glucose
Normal value: on an empty stomach less than 6.2, is less than 7.8 in two hours after the meal.
Hyperglycemia, hyperlipidemia, cholesterol patient, wherein, Mei Geshi is chosen by four age brackets
Execute example or comparative example or comparison, 20～within 30 years old, choose 100 examples, 30～40 years old choose 100 examples,
40～within 50 years old, choose 100 examples, 50～60 years old and choose 100 examples, men and women's ratio of four age brackets
Example is 1:1, and the people of these four age brackets exists the symptom of allergic dermatitis.
Embodiment, comparative example all take products obtained therefrom, and morning, noon and afternoon every day were each once, with one month
It is a cycle, within three months, is a course for the treatment of.
Clear water is taken in comparison, does not use other medicines, and morning, noon and afternoon every day were each once, with one month
It is a cycle, within three months, is a course for the treatment of.
Meanwhile, in the course for the treatment of, it is ensured that the diet situation of age-grade patient is consistent.
Standard of comparison is set to: (1) has effective: refer within the trimestral time blood glucose, blood fat,
Cholesterol has and declines largely, already close to, substantially close to or reached standard value.(2)
It is effective: to refer to that within the trimestral time blood glucose, blood fat, cholesterol have and decline largely,
Have close to or up the trend in standard.(3) invalid: refer within the trimestral time blood glucose,
Blood fat, cholesterol decline degree less or substantially without decline.
As can be known from the above table: embodiment is compared with comparative example 1, and all age group takes Lac regis apis honeybee
Effective number and effective number is had significantly to increase after balsam apple buccal tablet, this explanation and individually use
Lac regis apis dry powder is compared with propolis powder, and the formula of the present invention is to hyperglycemia, hyperlipidemia, cholesterol
There is significant curative effect.
Embodiment is compared with comparative example 2, after all age group takes Lac regis apis bee glue bitter gourd buccal tablet
There are effective number and effective number significantly to increase, formula increases a certain amount of Folium Pterocaryae
Dry powder, Herba Taraxaci dry powder, Poria dry powder, Spirulina powder, solid to hyperglycemia, hyperlipidemia, gallbladder
The improvement of alcohol can reach beyond thought effect.
Other part not being described in detail is prior art.
Claims (7)
1. a Lac regis apis bee glue bitter gourd buccal tablet, it is characterised in that: by main material and auxiliary material
Composition, described main material by 40～80 parts of Lac regis apis dry powders, 10～40 weight portion propolis powder,
5～20 parts of Fructus Momordicae charantiae extract powder, 4～18 Herba Menthae dry powder, 5～15 weight portions of weight portion
Fructus Luffae dry powder, 5～13 Fructus Cucumidis sativi dry powder, 3～8 Aloe dry powder, 2～5 of weight portion of weight portion
The Fructus Citri Limoniae dry powder of weight portion, 1～3 Folium Pterocaryae dry powder, 1～2.5 Pus of weight portion of weight portion
Herba Taraxaci dry powder, 0.5～1.5 weight portion Poria dry powder, 1～2 Spirulina powder compositions of weight portion,
Described auxiliary material is by 5～20 weight portion magnesium stearate, 3～5 microcrystalline Cellulose groups of weight portion
Become.
Lac regis apis bee glue bitter gourd buccal tablet the most according to claim 1, it is characterised in that:
Described main material by 50～70 parts of Lac regis apis dry powders, 20～30 weight portion propolis powder, 10～
15 parts of Fructus Momordicae charantiae extract powder, 6～15 Herba Menthae dry powder, 8～12 Fructus Luffaes of weight portion of weight portion
Dry powder, 8～12 Fructus Cucumidis sativi dry powder, 5～7 Aloe dry powder, 3～4 weights of weight portion of weight portion
The amount Fructus Citri Limoniae dry powder of part, 2～3 weight portion Folium Pterocaryae dry powder, 1.5～2 the Pu of weight portion public
English dry powder, 1～1.2 weight portion Poria dry powder, 1.2～1.8 Spirulina powder compositions of weight portion,
Described auxiliary material is by 8～15 weight portion magnesium stearate, 3.5～4.5 microcrystalline Cellulose of weight portion
Composition.
Lac regis apis bee glue bitter gourd buccal tablet the most according to claim 2, it is characterised in that:
Described main material is extracted by 60 parts of Lac regis apis dry powders, the propolis powder of 25 weight portions, 12 portions of Fructus Momordicae charantiaes
Thing powder, the Herba Menthae dry powder of 10 weight portions, the Fructus Luffae dry powder of 10 weight portions, the Huang of 10 weight portions
Melon dry powder, the Aloe dry powder of 6 weight portions, the Fructus Citri Limoniae dry powder of 3.5 weight portions, 2.5 weight portions
Folium Pterocaryae dry powder, the Herba Taraxaci dry powder of 1.8 weight portions, 1.1 weight portion Poria dry powder, 1.5 weights
The Spirulina powder composition of amount part, described auxiliary material is by 12 weight portion magnesium stearate, 4 weight portions
Microcrystalline Cellulose composition.
4. Lac regis apis bee glue bitter gourd described in any claim in preparation the claims 1-3
The method of buccal tablet, it is characterised in that it comprises the steps:
1) by Lac regis apis microwave vacuum drying at 80 DEG C, pulverize, cross 80 mesh sieves, obtain
Lac regis apis dry powder；
2) propolis is pulverized, cross 80 mesh sieves, obtain propolis powder；
3) fresh Fructus Momordicae charantiae organic solvent is extracted at 55 DEG C, by extracting solution Rotary Evaporators
Evaporation, is dried to obtain Fructus Momordicae charantiae extract powder；
4) fresh Fructus Luffae, fresh Aloe, lemon, fresh cucumbers, Poria is dry at 80 DEG C respectively
Dry 24～32h, pulverize, cross 30 mesh sieves, obtain Fructus Luffae dry powder, Aloe dry powder, Fructus Citri Limoniae dry powder,
Fructus Cucumidis sativi dry powder, Poria dry powder；
5) Herba Menthae, Folium Pterocaryae, Herba Taraxaci are dried at 60 DEG C 8～12h, pulverize, cross 30
Mesh sieve, obtains Herba Menthae dry powder, Folium Pterocaryae dry powder, Herba Taraxaci dry powder；
6) by weight by Spirulina powder, step 1) Lac regis apis dry powder of gained, step 2)
The propolis powder of gained, step 3) the Fructus Momordicae charantiae extract powder of gained, step 4) Fructus Luffae of gained
Dry powder, Aloe dry powder, Fructus Citri Limoniae dry powder, Fructus Cucumidis sativi dry powder, Poria dry powder, step 5) gained
Herba Menthae dry powder, Folium Pterocaryae dry powder, Herba Taraxaci dry powder blend are uniform, obtain main material；
7) meter weighs magnesium stearate, microcrystalline Cellulose, mix homogeneously by weight, obtains
Auxiliary material；
8) main material is mixed homogeneously with auxiliary material, tabletting, obtain Lac regis apis bee glue bitter gourd and contain
Sheet.
The method preparing Lac regis apis bee glue bitter gourd buccal tablet the most according to claim 4, its
It is characterised by, described step 3) in, organic solvent is dehydrated alcohol and glycerol is by volume
The mixed solvent of 30～50: 1 compositions.
The method preparing Lac regis apis bee glue bitter gourd buccal tablet the most according to claim 5, its
It is characterised by, described step 3) in, organic solvent is dehydrated alcohol and glycerol is by volume
The mixed solvent of 40～48: 1 compositions.
The method preparing Lac regis apis bee glue bitter gourd buccal tablet the most according to claim 5, its
It is characterised by, described step 3) in, organic solvent is dehydrated alcohol and glycerol is by volume
The mixed solvent of 46: 1 compositions.
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| CN201610299100.8A CN105962237A (en) | 2016-05-09 | 2016-05-09 | Royal jelly-propolis-momordica charantia lozenges and preparation method thereof |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106993788A (en) * | 2017-03-08 | 2017-08-01 | 北京野馨科技发展有限公司 | All Pure Nature royal jelly lozenge and preparation method thereof |
| CN108497417A (en) * | 2018-04-17 | 2018-09-07 | 宁夏仓吉生物科技有限公司 | A kind of compound buccal tablet of matrimony vine royal jelly and preparation method thereof |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1528407A (en) * | 2003-10-20 | 2004-09-15 | 中国农业科学院蜜蜂研究所 | A composition for preventing and treating diabetes |
-
2016
- 2016-05-09 CN CN201610299100.8A patent/CN105962237A/en active Pending
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1528407A (en) * | 2003-10-20 | 2004-09-15 | 中国农业科学院蜜蜂研究所 | A composition for preventing and treating diabetes |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106993788A (en) * | 2017-03-08 | 2017-08-01 | 北京野馨科技发展有限公司 | All Pure Nature royal jelly lozenge and preparation method thereof |
| CN108497417A (en) * | 2018-04-17 | 2018-09-07 | 宁夏仓吉生物科技有限公司 | A kind of compound buccal tablet of matrimony vine royal jelly and preparation method thereof |
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Address after: 430301 Hengdian Street Hengtian Road, Huangpi District, Wuhan City, Hubei Province Applicant after: Wuhan Sinter Food Co., Ltd. Address before: 430301 Hengdian Street Hengtian Road, Huangpi District, Wuhan City, Hubei Province Applicant before: WUHAN SIWEITE FOOD CO., LTD. |
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Application publication date: 20160928 |