CN105944070A - Medicine preparation for treating intensive care respiratory system infection and preparation method thereof - Google Patents

Medicine preparation for treating intensive care respiratory system infection and preparation method thereof Download PDF

Info

Publication number
CN105944070A
CN105944070A CN201610521125.8A CN201610521125A CN105944070A CN 105944070 A CN105944070 A CN 105944070A CN 201610521125 A CN201610521125 A CN 201610521125A CN 105944070 A CN105944070 A CN 105944070A
Authority
CN
China
Prior art keywords
parts
radix
powder
rhizoma
rhizoma zingiberis
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN201610521125.8A
Other languages
Chinese (zh)
Inventor
姚鲁肃
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Priority to CN201610521125.8A priority Critical patent/CN105944070A/en
Publication of CN105944070A publication Critical patent/CN105944070A/en
Pending legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/17—Gnetophyta, e.g. Ephedraceae (Mormon-tea family)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A61K36/237—Notopterygium
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/34—Campanulaceae (Bellflower family)
    • A61K36/346—Platycodon
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/484—Glycyrrhiza (licorice)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
    • A61K36/538—Schizonepeta
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/65—Paeoniaceae (Peony family), e.g. Chinese peony
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/906—Zingiberaceae (Ginger family)
    • A61K36/9068—Zingiber, e.g. garden ginger
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation or decoction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/50—Methods involving additional extraction steps
    • A61K2236/53—Liquid-solid separation, e.g. centrifugation, sedimentation or crystallization

Landscapes

  • Health & Medical Sciences (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Biotechnology (AREA)
  • Botany (AREA)
  • Medical Informatics (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines Containing Plant Substances (AREA)

Abstract

The invention discloses a medicine preparation for treating intensive care respiratory system infection. The medicine preparation is prepared from the following ingredients in parts by weight: 7 to 9 parts of herba ephedrae, 5 to 7 parts of radix paeoniae alba, 9 to 11 parts of fresh ginger, 5 to 7 parts of notopterygium roots, 3 to 7 parts of radix platycodonis, 7 to 9 parts of herba schizonepetae, 3 to 5 parts of affine cudweed and 13 to 15 parts of liquorice roots. The invention also provides a preparation method of the medicine preparation. The medicine preparation provided by the invention has the obvious curative effect on the intensive care respiratory system infection.

Description

A kind of pharmaceutical preparation that can be used for Intensive Care Therapy respiratory system infection and preparation method thereof
Technical field
The present invention relates to pharmaceutical technology field, a kind of medicine that can be used for Intensive Care Therapy respiratory system infection Thing preparation and preparation method thereof.
Background technology
At present, respiratory system (Respiratory System) is carried out body and the extraneous device carrying out gas exchange The general name of official.The function of respiratory system mainly carries out gas exchange with extraneous, gives off carbon dioxide, and inhales Enter oxygen, carry out metabolism.Respiratory system includes respiratory tract (nasal cavity, pharynx, larynx, trachea-bronchial epithelial cell) And lung.
Respiratory system disease is a kind of commonly encountered diseases, frequently-occurring disease, major lesions trachea-bronchial epithelial cell, pulmonary and Thoracic cavity, the many coughs of pathological changes the lighter, chest pain, breathing are impacted, and severe one dyspnea, anoxia are even breathed Exhaustion and lethal.Mortality rate in city accounts for the 3rd, then accounts for first place in rural area.Respiratory system infection is Class maximum, modal in respiratory system disease, its often with heating, inflammation, cough and breathe system The pain of system.Doctor trained in Western medicine many employings antibiotic, antiviral and hormonotherapy at present, therapeutic effect is barely satisfactory, And side effect is big, easily causes the abuse of antibiotic.The traditional Chinese medical science is thought, respiratory system infection belongs to " coughing of Chinese medicine Cough ", " phlegm retention ", the category such as " cough with asthma ".Think that exopathogen is attacked and lung, spleen, the dirty malfunction of kidney three, It it is the main cause causing primary disease.Human righteousness is not enough, defends outer dereliction of duty, being invaded by exogenous pathogen, and exopathogen both can be The heresy of wind and cold, it is possible to be the heresy of wind heat, it is possible to the heresy heat-transformation of wind and cold, invades lungs, makes impaired depurative descending of lung QI；Or Insufficiency of lung-QI, weakened defensive QI, feel exopathogen again；Or the most weak, deficiency of both the splenic and pulmonary QI, dysfunction of the spleen in transportation, wet poly- Become expectorant, stop storing in lung；Or lung has chronic disease, feel exopathogen again；Or after prolonged illness, spleen lung undermine kidney, cause Deficiency of kidney-QI, improving inspiration by invigorating kidney-QI is had no right.Mainly there is a following typing:
1, wind and cold bundle table.Card is shown in: aversion to wind and cold is heavier, with heating, and lossless or hypohidrosis, nasal obstruction, flow thin nasal discharge, Sneeze, headache, limb aching pain, mouth is thirsty, or coughs and tell dilute white expectorant, hoarseness, thin white fur of tongue and moisten, Floating and tense pulse.The rule for the treatment of: relieving the exterior syndrome with drugs of pungent in flavor and warm in nature, heating wind and cold.
2, wind heat violates table.Card is shown in: substantially, micro evil wind is trembled with fear, hypohidrosis, distending pain in the head in heating, nasal obstruction, or stream Huang Tears, thirsty, swallow red and pain, cough, tell yellow sputum or glue expectorant in vain, tongue tip side of red, white and thin fur and dry or micro-Huang, Floating and rapid pulse.The rule for the treatment of: relieving the exterior syndrome with drugs of pungent in flavor and cool in nature, evacuates heating.
3, heat-damp in summer attacks table.Card is shown in: sick summer, disease sees fever with aversion to cold, lossless or hypohidrosis, and giddy goes up painful, Nasal obstruction watery nasal discharge, uncomfortable in chest, vomiting and nausea tending to vomit, tire is the most greasy or yellow greasy, relaxed and soft pulse or moisten number.The rule for the treatment of: dispelling summer-heat from superficies of the body, Removing dampness for regulating stomach.
4, heat attacks table.Card is shown in: disease is mainly in autumn, and disease sees heating, slight chill, headache, hypohidrosis, cough Few expectorant, thirsty, dry pharynx lip is dry, xerosis cutis, tongue tip side of red, white and thin fur and do, floating pulse.The rule for the treatment of: pungent Cool induce sweat, sweet cold moisturize.
But, a kind of Chinese medicine preparation, it is possible to play preferably at Intensive Care Therapy respiratory system infection Assosting effect.
Summary of the invention
Technical problem solved by the invention is to provide a kind of medicine that can be used for Intensive Care Therapy respiratory system infection Thing preparation and preparation method thereof, thus solve the problem in above-mentioned background technology.
Technical problem solved by the invention realizes by the following technical solutions:
A kind of pharmaceutical preparation that can be used for Intensive Care Therapy respiratory system infection, including the component of following weight portion:
Herba Ephedrae 7-9 part；
Radix Paeoniae Alba 5-7 part；
Rhizoma Zingiberis Recens 9-11 part；
Rhizoma Et Radix Notopterygii 5-7 part；
Radix Platycodonis 3-7 part；
Herba Schizonepetae 7-9 part；
Mus grass 3-5 part；
Radix Glycyrrhizae 13-15 part.
In the present invention, as the preferred technical scheme of one, one can be used for Intensive Care Therapy respiratory system infection Pharmaceutical preparation, the component of following weight portion be prepared from:
8 parts of Herba Ephedrae；
The Radix Paeoniae Alba 5 parts；
10 parts of Rhizoma Zingiberis Recens；
Rhizoma Et Radix Notopterygii 6 parts；
Radix Platycodonis 5 parts；
Herba Schizonepetae 8 parts；
Mus grass 5 parts；
14 parts of Radix Glycyrrhizae.
In the present invention, as the preferred technical scheme of one, the preparation method of this pharmaceutical preparation, including as follows Step:
(1) Herba Ephedrae is sieved, remove impurity, be placed in mill groove, grind loosen into fiber velvet-like；By the Radix Paeoniae Alba Being soaked in water to eighty per cant thoroughly, pull out, solarization is dried in the air, and profit to inside and outside humidity is uniform, section, then puts interior the stir-fry of pot To coke yellow, spray clear water is a little, takes out, dries；Take fresh ginger, clean, mash, squeeze extracting juice, Stand, divide the opaque taking precipitation, cold drying, obtain powder, then weigh；By Herba Schizonepetae cutting, put In pot, micro-stir-fry at 70-90 DEG C, taking-up cools；Radix Glycyrrhizae section is added cooked Mel and a little boiled water, mixes After even the most vexed, put fry in pot to buff and tack-free time, take out and dry in the air cool, grind to form 50-60 mesh powder；
(2) weigh step (1) obtain Herba Ephedrae, the Radix Paeoniae Alba, Rhizoma Zingiberis powder, mix homogeneously, grind to form 30-50 Purpose powder, then will add the distilled water of 10-15 times of weight, reflux, extract, at 80-85 DEG C in powder 30-45 minute, then stand cooling, be filtrated to get supernatant；
(3) Herba Schizonepetae obtained, and Rhizoma Et Radix Notopterygii, Radix Platycodonis and Mus are processed by supernatant adds step (1) Grass, boils 20-35 minute, refluxes, then filter, obtain filtrate when boiling, and will add step (1) in filtrate The Radix Glycyrrhizae powder obtained, stirring mixing, obtain pharmaceutical preparation.
The pharmaceutical preparation that the present invention provides, when taking, three times a day, each takes 35-55ml, after taking again Drink the warm water of at least 100ml.
In the present invention, Herba Ephedrae, [nature and flavor] hardship pungent, micro-, temperature.[return through] returns lung, bladder warp.[function master Control] diaphoresis cold expelling, depressed lung-energy dispersing, inducing diuresis to remove edema.For anemofrigid cold, uncomfortable in chest breath with cough, edema due to wind pathogen edema； Bronchial asthma.Herba ephedrae nourishing the lung to arrest cough.It is used for table disease to solve, asthma and cough.Caulis Ephedrae containing alkaloid 1～ 2%, wherein 40～90% is ephedrine, is secondly the l-N-methylephedrine of pseudoephedrine and trace, d-N- Methyl pseudoephedrine, l-demethyl ephedrine, d-Nor pseudo ephedrine, ephedine；Again containing catechotannin 6% and volatile oil, containing l-alpha-terpineol in volatile oil.Test proves, Herba Ephedrae has antitussive effect.Use histamine Aerosol causes to breathe heavily method test, and mouse peritoneal injection Herba Ephedrae volatile oil 0.1ml/kg has antiasthmatic effect, and Herba Ephedrae is volatilized The line of oils mice cause time of breathing heavily is 7.2 ± 2.1 minutes, and normal saline group is 2.2 ± 0.7 minutes (P ＜ 0.05). The test of phenol red method finds have, to mouse stomach Herba Ephedrae volatile oil 0.4ml/kg, the effect promoting that trachea excretion is phenol red. Meanwhile, also there is antibiosis and antiviral functions: teamster's tea in vitro tests is to staphylococcus aureus, first kind chain Coccus, second kind streptococcus, charcoal trace bacillus, diphtheria corynebacterium, bacillus pyocyaneus, dysentery bacterium, Bacillus typhi table Antibacterial action the most in various degree.Herba Ephedrae volatile oil is to hemophilus influenza, escherichia coli, Candida albicans ball Bacterium all has bacteriostasis in various degree, and Asia influenza A virus is had inhibitory action, sick to influenza A Poison PR, the mice that strain is infected has therapeutical effect.Teamster's tea is dense to the minimum suppression of Asia influenza A virus Degree is 2mg/ml.
The Radix Paeoniae Alba, [nature and flavor] are bitter, sour, are slightly cold.[return through] returns liver, spleen channel.[function cures mainly] suppressing the hyperactive liver pain relieving, Nourishing blood for regulating menstruation, astringing YIN to stop sweating.For dizziness of having a headache, hypochondriac pain, stomachache, limb pain twin, blood deficiency and yellow complexion, the moon Through uncomfortable, spontaneous perspiration, night sweat.Root contains paeoniflorin, paeonol, paeoniflorin, benzoic acid about 1.07%, waves Hair oil, fatty oil, resin, tannin, sugar, starch, phlegmatic temperament, protein, cupreol and triterpenes. Another Sichuan product person, containing a kind of acidic materials, has inhibitory action to staphylococcus aureus.Flower is containing astragalin, mountain Naphthol 3,7-diglucoside, volume gallotannin (more than 10%), pyrethrin 0.13%, 13-first Base tetradecanoic acid, cupreol, pentacosane etc..Leaf contains tannin.[pharmacological action] has antibacterial action.Chinese herbaceous peony Medicine or paeoniflorin have more weak antiinflammatory action, to yeast, chondrus ocellatus Holmes colloidality and dextran pedal swelling There is inhibitory action in various degree, share synergism with licorice ingredient FM100, abdominal cavity blood capillary is led to Property also has more weak inhibitory action thoroughly.Rat Ovum Gallus domesticus album acute inflammation and granuloma induced by implantation of cotton pellets are all had by Radix Paeoniae Alba extract Inhibitory action.White peony root's total glycoside 50mg/kg, every day 1 time, continuous 11 days, closes Rat Experimental adjuvanticity Joint inflammation has obvious inhibiting effect.In Radix Paeoniae, contained paeonol, benzoylpaeoniflorin and oxypaeoniflorin also have anti- Scorching effect.Paeoniflorin has preventive effect to rat stress ulcer, share with FM100 at pylorus-ligated rats In terms of suppression gastric secretion, there is synergism, but Radix Paeoniae extracting solution makes gastric acidity slightly rise.
Rhizoma Zingiberis Recens, [nature and flavor] are pungent, tepor.[return through] returns lung, spleen, stomach warp.[function cures mainly] relieving exterior syndrome and dispelling cold, Warming middle-JIAO to arrest vomiting, preventing phlegm from forming and stopping coughing.For anemofrigid cold, gastrofrigid vomiting, cold-phlegm is coughed.Rhizoma Zingiberis Recens becomes containing volatility Point: α-zingiberene (α-zingiberene), β-santalol (β-santalol), β-phellandrene (β-phellandrene), β-bisabolence (β-bisabolene), α-curcumene (α-curcumene), zingiberol (zingiberol), perillaldehyde (perillaldehyde), neral (neral), geranial (geranial), 2-carane Alcohol (2-caraneol), 3-carol, lauro lene (camphene), β-ocimene (β-ocimene), α-bergmot oil alkene (α-bergamotene), β-gold just joyous alkene (β-farnesene), myrcene (myrcene), nopinene (β-pinene), 2-Borneolum Syntheticum (2-borneol), citral (citral), 7-alkene in the Meng [7-menthene], different fenchol (isofenchyl alcohol), α-farnesene, 1,3,3-trimethyl three ring [2.2.1.02,6]-heptane [1,3, 3-trimethyltricyclo [2.2.1.02,6] heptane], 2,6-dimethyl-6-(4-methyl-3-pentenyl)-bicyclo- [3.1.1]-2-heptane [2,6-dimethyl-6-(4-methyl-3-pentenyl)-bicyclo [3.1.1]-2-heptene], 1, 3,3-trimethyl-2-oxabicyclo [2.2.2] octanes [1,3,3-trimethyl-2-oxabicyclo [2.2.2] octane], 1-(1,5-dimethyl-4-vinyl)-4-methylbenzene [1-(1,5-eimethyl-4-hexenyl)-4-methylbenzene] And tens of kinds of Rhizoma Alpiniae Officinarum terpene lactones (galanolactone) etc.；Piquancy component: the peppery alcohol of 6-Rhizoma Zingiberis Recens (6-gingerol), 3- The peppery alcohol of Rhizoma Zingiberis Recens, the peppery alcohol of 4-Rhizoma Zingiberis Recens, the peppery alcohol of 5-Rhizoma Zingiberis Recens, the peppery alcohol of 8-Rhizoma Zingiberis Recens, the peppery alcohol of 10-Rhizoma Zingiberis Recens, the peppery alcohol of 12-Rhizoma Zingiberis Recens, the peppery glycol of 6-Rhizoma Zingiberis Recens (6-gingediol), the peppery glycol of 4-Rhizoma Zingiberis Recens, the peppery glycol of 8-Rhizoma Zingiberis Recens, the peppery glycol of 10-Rhizoma Zingiberis Recens, the peppery glycol of 6-methyl Rhizoma Zingiberis Recens (6-gingediol), the peppery glycol of 4-Rhizoma Zingiberis Recens, the peppery glycol of 8-Rhizoma Zingiberis Recens, the peppery glycol of 10-Rhizoma Zingiberis Recens, the peppery glycol of 6-methyl Rhizoma Zingiberis Recens (6-methylgingediol), 4-Rhizoma Zingiberis Recens peppery glycol diacetate (4-gingediacetate), 6-Rhizoma Zingiberis Recens peppery glycol diacetic acid Ester, 6-methyl Rhizoma Zingiberis Recens glycol diacetic acid (6-methylgingediacetate), the peppery diketone of 6-Rhizoma Zingiberis Recens (6-gingerdione), The peppery diketone of 10-Rhizoma Zingiberis Recens, the peppery diketone of 6-dehydrogenation Rhizoma Zingiberis Recens (6-dehydrogingerdiong), the peppery diketone of 10-dehydrogenation Rhizoma Zingiberis Recens, 6-second The peppery alcohol of acyl Rhizoma Zingiberis Recens (6-acetylgingerol), the peppery ketenes of 6-Rhizoma Zingiberis Recens (6-shogaol) etc..Rhizoma Zingiberis Recens is to circulation and the work of breathing With: normal person's chewing Rhizoma Zingiberis Recens 1g (not swallowing), contraction can be made to flatten all and to raise 11.2mm mercury column, diastolic pressure Rise 14mm mercury column, to pulse frequency then without significant impact.Alcoholic extract to anesthetized cat vasomotor center and Respiratory center has excitation, also has direct excitation to heart.
Rhizoma Et Radix Notopterygii, [nature and flavor] are pungent, bitter, temperature.[return through] returns bladder, kidney channel.[function cures mainly] cold expelling, Dispel the wind, dehumidifying, pain relieving.Have a headache for anemofrigid cold, rheumatic arthralgia, aching pain in shoulder and back.Rhizoma Et Radix Notopterygii rhizome is containing perfume Bean essence compounds: different imperatorin (isoimperatorin0.38%), the different imperatorin of 8-methoxyl group (cnidilin0., 5-hydroxyl bergmot element (notopterol1.2%), bergapten (bergapten0.009%), 8- (3,3-dimethyl-allyl)-5 demethyl bergapten (demethylfuroinnarin) i.e. 5-hydroxyl-8-(3, 3-dimethyl thiazolinyl)-psoralen [5-hydroxy-8 (3,3-dimethylally)-psoralen, 0.012%], 5-demethyl bergmot alcohol (bergaptol0.088%), decuroside unit (nodakenetin0.04%), pale reddish brown Radix Peucedani glycoside (nodakenin trace), bergmot alcohol-O-β-D-Glucopyranose. (bergaptol-O-β-D-glucopyranoside0.075%), 6-O-trans-Resina Ferulae acyl decuroside (6-O-trans-feruloylnodakenin0.022%) [1], columbianetin (colrmbianetin), dihydro mountain Celery alcohol glycoside (columbiananine), imperatorin (imperatorin), India's element (marmesin) [2]； Phenoloid: p-leptodactyline Fructus Foeniculi acid esters (p-hydroxyphenethyl anisate0.005%), Ah Acid Wei (ferulic acid0.89%)；Phytosterin compound: cupreol glycoside (β-sitosterol Glucoside) [1], cupreol (β-sitosterol) [2]；Volatile oil (about 2.7%), its composition has α-side Cupressene (α-thujene), α and nopinene (α, β-pinene), β ocimene (β-ocimene), γ-terpinene (γ-terpinene), limonene (limonene), 4-terpinenol (4-terpinenol), acetic acid Borneol acetate (bornylacetate), α-(king is ancient) (king's bar) alkene (α copaene), trans-β-farnesene (β-farnesene), parsley brain (apiol), guiol (guaiol) and benzyl benzoate (benzylbenzoate) Deng [3]；Fatty acid: ten tetra-carbonic methyl ester (methyltetradecanoate), 12-methyl ten tetra-carbonic methyl ester (12-methyltetradecanoic acid methyl ester), Palmitic acid methyl ester (methylhex-adecanoate), 4,8,12-trimethyl ficocerylic acid methyl ester (4,8, 12-trimethyl-tridecanoic acid methyl ester), 14-methyl Palmitic acid methyl ester (14-methyl-hexadecanoic acid methyl ester), methyl oleate (methyl-9-octadecenoate), Methyl stearate (methyloctadecanoate), 20 methyl carbonates (methyleicosanoate), 11-20 Carbon enoic acid methyl ester (methyl-11-eicosenoate) etc. 14 kinds；Amino acids: aspartic acid (aspartic acid), Glutamic acid (glutamic acid), thick ammonia alcohol (arginine), leucine (leucine), isoleucine (isoleucine), Valine (valine), threonine (threonine), phenylalanine (phenylalanine) and methionine Etc. (methyionine) 19 kinds；Saccharide, rhamnose (rhamnose), fructose (fructose), glucose (glucose) And sucrose (sucrose) [4].Rhizoma Et Radix Notopterygii also (phenethylferulate) Han phenethyl ferulic acid ester [5] .2. Kuan Ye Qiang Under ground portion compound Han Coumarins alive: bergmot element (berg-amottin, bergaptin), different imperatorin (the different imperatorin of 0.62%, 8-methoxyl group (0.024%), 5-gate of a lane basic note chess element (0.083%), in bergmot Ester (0.008%), and 8-(3,3-dimethyl-allyl-5-de-methoxy bergapten (0.03%), bergmot alcohol (0.026%), decuroside unit (0.053) %, decuroside (1.2) %, 6-O-trans-Resina Ferulae acyl Decuroside (0.73) %, columbianetin；Phenoloid；P-hydroxyphenylmethyl anisic acid (0.07%), Ferulic acid (0.83%).Also containing cupreol glycoside and volatile oil, volatile oil is mainly composed of australene Alkene (36.30%), nopinene (21.04%), limonene (14.42%), additionally, also have aldehyde (hexanal), Enanthaldehyde (heptanal), octanal (octanal), sabinene (sabinene), lauro lene (camphene), Laurel Alkene (myrcene), α-phellandrene (α-phellandrene), 3-carene (3-carene), 2-carene (2-carene), Cymol (p-cymene), α, γ-terpinene, 4-terpinenol, borneol acetate and β-celery 20 kinds of alkene (β-selinene) etc..There is preferable antiinflammatory refrigeration function.Test proves, pyrogenicity to yeast The impact of rat temperature: 2.5h after rat skin lower injection l5% yeast suspension 10ml/kg pyrogenicity, then distinguishes With Rhizoma Et Radix Notopterygii volatile oil 1.328ml/kg gavage and 0.133ml/kg gastric infusion, after administration, different time surveys rat Body temperature.Result and the volatile oil comparing two kinds of different approaches and various dose all can make rat temperature obvious Reduce, there is significant refrigeration function.Impact on mice dimethylbenzene dropsy of ear: mice gavage Rhizoma Et Radix Notopterygii respectively Volatile oil 1.328,0.664,0.332,0.221ml/kg, after administration, auris dextra melted paraxylene 0.03ml/ is only, Calculate left and right auricle weight difference (mg).Result compares with matched group (12.5 ± 6.01), be respectively as follows: 6.6 ± 4.40, 7.2±3.16、7.0±4.21、15.9±5.28.Front 3 dosage groups compare P ＜ 0.05 with matched group.Show Can significant suppression dimethylbenzene dropsy of ear.The impact of Carrageenan foot swelling: Oral Administration in Rats 1.328,0.664ml / kg or lumbar injection 0.133,0.066ml/kg have suppression to Rat Carrageenan (1%0.1ml) foot swelling Effect.Compare with matched group and 1.328ml/kg group injection carrageenin after 3 or 4 hour P ＜ 0.05 be administered orally, Oral 0.664ml/kg group 24 little P constantly ＜ 0.001, lumbar injection 0.133ml/kg group 24 hours, P ＜ 0.05.Impact on rat dextran foot swelling: Oral Administration in Rats Rhizoma Et Radix Notopterygii volatile oil 1.328,0.664, 0.332ml/kg, in rat hindleg plantar aponeurosis hemostasis 1.2% dextran 0.1ml/ is only administered latter 30 minutes. Result compares with matched group, only 1.328ml/kg group, has significant difference in 3,5,6 little inhibitory action constantly Different P ＜ 0.05.
Radix Platycodonis, [nature and flavor] are bitter, pungent, flat.[return through] returns lung meridian.[function cures mainly] lung qi dispersing, sore-throat relieving, dispel Expectorant, evacuation of pus.For cough with copious phlegm, uncomfortable in chest not smooth, pharyngalgia, hoarseness, lung abscess vomiting pus, skin infection difficulty in discharging of pus. Radix Platycodonis is utilized to test, after anesthetized dog is administered orally decoct 1 g/kg, the significant increase of respiratory mucus secretory volume, Action intensity can be compared with ammonium chloride.Separately have been reported that and think that its effect is better than Radix Polygalae and is inferior to senea, and use During phenol red excretion algoscopy, its effect is more weak than Radix Polygalae.To anesthetized cat, also have and promote respiratory mucus secretion Effect.Phlegm-dispelling functions, mainly due to caused by Saponin contained therein, can stimulate gastric mucosa time low dose of, draw Play mild nausea, thus increase bronchial secretion reflectingly.According to the comparison that haemolysis is strong and weak, it is believed that Wild Radix Platycodonis is stronger than the effect of cultivation, unpeeled more much better than than the effect of peeling, the work that pale reddish brown ratio is spent in vain With slightly larger, the effect growing 2 years is the strongest, and 1 year take second place, the effect of 3 years is minimum.Compared with Radix Polygalae, Fructus Citri tangerinae The haemolysis of stalk is more weak.Containing multiple Saponin, the most having got 18 kinds of triterpenoid saponin, they are；Radix Platycodonis soap Glycoside (platycodin) A, C, D [1], D2, D3, remove celery glycosyl kikyosaponin (deapioplatycodin) D, D3,2-O-=acetyl group kikyosaponin (2-O-acetylplatycodin) D2,3-O-acetyl group Radix Platycodonis soap Glycoside (3-O-acetylplaty-codin) D2, polygalin (polyglalacin) D, D2,2-O-acetyl group is remote Will Saponin (2-O-acetylpolygalacin) D, D2,3-O-acetyl group polygalin (3-O-acetylpolygalacin) D, D2, Radix Platycodonis glycoside acid-A methyl ester (methyl platyconate-A), 2-O- Methyl Radix Platycodonis glycoside acid-A methyl ester (methyl-2-O-methyplatyconate-A), Radix Platycodonis glycoside acid-A lactone (platyconic acid-A lactone).Have and significantly eliminate the phlegm and antitussive effect: anesthetized dog is administered orally this product decoct 1g/kg, the secretory volume of the significant increase respiratory mucus of energy, its intensity can be compared with ammonium chloride.To anesthetized cat also There is obvious phlegm-dispelling functions.Have been reported that the phlegm-dispelling functions of kikyosaponin is better than Radix Polygalae, inferior to senea (Poygala senegaL.).Mice phenol red method result of the test is then weaker than Radix Polygalae.When contained by Radix Platycodonis, Saponin is administered orally, throat is glued Film and gastric mucosa cause stimulation to a certain degree, cause respiratory mucosa hypersecretion reflectingly, make sputum dilute Releasing, promote it to discharge, rough kikyosaponin has antitussive effect.Guinea pig intraperitoneal injection and antitussive median effective dose For 6.4mg/kg.
Herba Schizonepetae, [nature and flavor] are pungent, tepor.[return through] returns lung, Liver Channel.[function cures mainly] induces sweat scattered wind, thoroughly Rash.For catching a cold, headache, measles, rubella, skin infection from the beginning of.Parch to black treating hematochezia, metrorrhagia, puerperal blood faints. The aerial parts of Herba Schizonepetae, fringe, GENGGE contain volatile oil 1.12%, 1.69%, 0.60%, and wherein main component is equal For pulegone (pule-gone), menthone (menthone), isomenthone (isomenthone) and different Hu Menthone (isopulegone)；Also contain: ethyl pentyl group ether (1-ethoxypentane), 3-methyl ring penta Ketone (3-methylcyclopentanone), 3-methylcyclohexanone (3-methylcy-clohexanone), benzaldehyde (benzaldehyde), 1-OCOL (1-octen-3-ol), 3-octanone (3-octanone), 3-capryl alcohol (3-octanol), P-cymene (cymene), limonene (limonene), neomenthol (neomenthol), Menthol (menthol), piperitone (piperitone), Mentha piperita ketenes (piperitenone), oxalene (humulene), Flos Caryophylli alkene (caryophyllene)；Possibly together with nopinene in aerial parts volatile oil (β-pinene), 3,5-dimethyl-2-cyclohexene-1-ketone (3,5-dimethyl-2-cyclohexen-1-one), second Thiazolinyl dimethylbenzene (ethenyl dimethyl benzene), cineole (cineole), Eucarvone (carvone), Dihydro Xun thread ketone (dihydrocarvone), cordovan life oxalene ketone (verbenone) [1].Spike contains monoterpene Constituents: Herba Schizonepetae glycoside (schizoneptoside) A, B [2], C, E [4], nepetol (schizonol) Herba Schizonepetae two Alcohol (schizoneodiol) [4]；Flavones ingredient: diosmetin (diosmetin), hesperidin i.e. hesperetin-7-O- Rutinoside (hesperidin, hesperetin-7-O-rutinoside).Herba Schizonepetae has antipyretic effect: by wound Cold polyvalent vaccine makes fever in rabbits, gives Schizonepeta tenuifolia decoct or ethanol preserved material 2g/kg gavage, the faintest Refrigeration function.Herba Schizonepetae decoct has antipyretic effect.D-menthone in Herba Schizonepetae is analgesic main component, 3-methyl cyclohexanone also has analgesic activity.Resisting pathogenic microbes effect: Herba Schizonepetae decoct in vitro tests is to golden yellow Portugal Grape coccus and diphtheria corynebacterium have stronger antibacterial action.Secondly to anthrax bacillus, group B streptococcus, typhoid fever bar Bacterium, dysentery bacterium, bacillus pyocyaneus, Bacillus tuberculosis etc. all show certain inhibitory action.50% Herba Schizonepetae is decocted Agent every Embryo Gallus domesticus 0.1ml is to influenza A virus PR8 strain unrestraint effect.
Mus grass, [nature and flavor] sweet in the mouth；Micro-acid；Property flat.[return through] returns lung meridian.[function cures mainly] only reduces phlegm Cough；Expelling wind and removing dampness；Removing toxic substances.Main cough with asthma abundant expectoration；Rheumatic arthralgia；Have loose bowels；Edema；Favism；Red and white leukorrhea Under；Carbuncle furuncle；Scrotum pruritus due to damp pathogen；Urticaria；Hypertension.[chemical composition] herb contains 5% flavonoid glycoside, 0.05% volatile oil, Alkaloid and sterol, 0.58% non-shoulders compound, again containing vitamin B, Radix Dauci Sativae, Chlorophyll, resin, fat etc..Flower is containing luteolin-4-β-D-Glucose glycoside (luteline-4-β-D-glucoside).Antitussive effect: after mice sucks strong aqua ammonia formation chronic cough repeatedly, Gavage Herba Gnaphalii Affinis decoct, have certain antitussive action.Decoct 4g/kg mouse stomach, has antitussive effect.Antibacterial Effect: 100% decoct flat board burrows method, and staphylococcus aureus, S. sonnei are had inhibitory action.
Radix Glycyrrhizae, [nature and flavor] are sweet, flat.[return through] GUIXIN, lung, spleen, stomach warp.[function cures mainly] spleen reinforcing QI invigorating, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, relieving spasm to stop pain, coordinating the actions of various ingredients in a prescription.For weakness of the spleen and stomach, fatigue and weakness, Shortness of breath and palpitation, cough with copious phlegm, gastral cavity abdomen, extremity contraction urgency pain, carbuncle sore tumefacting virus, cushion toxicity, strong. Antiinflammatory and antiallergic action: enoxolone is to the granuloma induced by implantation of cotton pellets of rat, formaldehyde edema, tuberculin Reaction, subcutaneous granulation capsule inflammation all have inhibitory action.Ammonium glycyrrhizinate, Monosodium glycyrrhetin can effectively affect skin The phase of oozing out of lower granulation capsule inflammation and proliferative phase, its action intensity is weaker than or close to cortisone.Glycyrrhizic acid The antiinflammatory action of various preparations, the activity with succinate is higher, but toxicity is the biggest.Radix Glycyrrhizae antiinflammatory resistance The principle of state reaction illustrates the most completely.Radix Glycyrrhizae has phlegm-dispelling functions, can promote throat and bronchial secretion, Expectorant is made easily to bring up.
Owing to have employed above technical scheme, the method have the advantages that
In the pharmaceutical preparation of the present invention, with Herba Ephedrae, the Radix Paeoniae Alba, Rhizoma Zingiberis Recens as monarch drug, play depressed lung-energy dispersing, reduce phlegm Effect of cough-relieving, has the most crucial effect for Intensive Care Therapy patients with respiratory tract infections；With Rhizoma Et Radix Notopterygii, Radix Platycodonis is ministerial drug, the effect that auxiliary plays removing toxic substances, eliminates the phlegm, and prevents Intensive Care Therapy respiratory system infection further The degree of depth that patient causes because of abundant expectoration infects；With Herba Schizonepetae, Mus grass as adjuvant drug, induce sweat scattered wind, play antiviral, The effect of antipyretic, analgesic, make Intensive Care Therapy patients with respiratory tract infections from pain, the hardship of heating, with sweet Grass, for making medicine, makes expectorant easily bring up, meanwhile, and coordinating the actions of various ingredients in a prescription.
The pharmaceutical treatment of the present invention 120 example Intensive Care Therapy patients with respiratory tract infections are randomly divided into treatment group and Each 60 examples of matched group.Treatment 19 years old group age～65 years old, average course of disease is 35.7 hours.Matched group 60 Example, at 21.34 years old age, average course of disease is 34 hours.
On the basis of infection, the Primary Care such as eliminate the phlegm are identical, treatment group takes what the present invention provided Pharmaceutical preparation, three times a day, each takes 35-55ml, drinks the warm water of at least 100ml after taking again；Right The warm water of respective amount is given according to group.Two groups the most three times a day, within 7 days, was 1 course for the treatment of.
Result shows: treatment group total effective rate 93.1%, is significantly higher than matched group 82.4% (P < 0.05), it was demonstrated that The pharmaceutical preparation that the present invention provides is curative effect affirmative in Intensive Care Therapy patients with respiratory tract infections, and untoward reaction Few.
Detailed description of the invention
For the technological means making the present invention realize, creation characteristic, reach purpose and be easy to understand with effect, Below in conjunction with specific embodiment, the present invention is expanded on further.
Embodiment 1
A kind of pharmaceutical preparation that can be used for Intensive Care Therapy respiratory system infection, including the component of following weight portion: 7 parts of Herba Ephedrae；The Radix Paeoniae Alba 5 parts；9 parts of Rhizoma Zingiberis Recens；Rhizoma Et Radix Notopterygii 5 parts；Radix Platycodonis 3 parts；Herba Schizonepetae 7 parts；Mus grass 3 parts；13 parts of Radix Glycyrrhizae.
The preparation method of this pharmaceutical preparation, comprises the steps:
(1) Herba Ephedrae is sieved, remove impurity, be placed in mill groove, grind loosen into fiber velvet-like；By the Radix Paeoniae Alba Being soaked in water to eighty per cant thoroughly, pull out, solarization is dried in the air, and profit to inside and outside humidity is uniform, section, then puts interior the stir-fry of pot To coke yellow, spray clear water is a little, takes out, dries；Take fresh ginger, clean, mash, squeeze extracting juice, Stand, divide the opaque taking precipitation, cold drying, obtain powder, then weigh；By Herba Schizonepetae cutting, put In pot, micro-stir-fry at 70 DEG C, taking-up cools；Radix Glycyrrhizae section is added cooked Mel and a little boiled water, mixes thoroughly After the most vexed, put fry in pot to buff and tack-free time, take out and dry in the air cool, grind to form 50 mesh powder；
(2) weigh step (1) obtain Herba Ephedrae, the Radix Paeoniae Alba, Rhizoma Zingiberis powder, mix homogeneously, grind to form 30 purposes Powder, then will in powder add 10 times of weight distilled water, reflux, extract, 30 minutes at 80 DEG C, so Rear standing is lowered the temperature, and is filtrated to get supernatant；
(3) Herba Schizonepetae obtained, and Rhizoma Et Radix Notopterygii, Radix Platycodonis and Mus are processed by supernatant adds step (1) Grass, boils 20 minutes, refluxes, then filter, obtain filtrate when boiling, and will add step (1) in filtrate The Radix Glycyrrhizae powder obtained, stirring mixing, obtain pharmaceutical preparation.
Embodiment 2
A kind of pharmaceutical preparation that can be used for Intensive Care Therapy respiratory system infection, including the component of following weight portion: 9 parts of Herba Ephedrae；The Radix Paeoniae Alba 7 parts；11 parts of Rhizoma Zingiberis Recens；Rhizoma Et Radix Notopterygii 7 parts；Radix Platycodonis 7 parts；Herba Schizonepetae 9 parts；Mus Grass 5 parts；15 parts of Radix Glycyrrhizae.
The preparation method of this pharmaceutical preparation, comprises the steps:
(1) Herba Ephedrae is sieved, remove impurity, be placed in mill groove, grind loosen into fiber velvet-like；By the Radix Paeoniae Alba Being soaked in water to eighty per cant thoroughly, pull out, solarization is dried in the air, and profit to inside and outside humidity is uniform, section, then puts interior the stir-fry of pot To coke yellow, spray clear water is a little, takes out, dries；Take fresh ginger, clean, mash, squeeze extracting juice, Stand, divide the opaque taking precipitation, cold drying, obtain powder, then weigh；By Herba Schizonepetae cutting, put In pot, micro-stir-fry at 90 DEG C, taking-up cools；Radix Glycyrrhizae section is added cooked Mel and a little boiled water, mixes thoroughly After the most vexed, put fry in pot to buff and tack-free time, take out and dry in the air cool, grind to form 60 mesh powder；
(2) weigh step (1) obtain Herba Ephedrae, the Radix Paeoniae Alba, Rhizoma Zingiberis powder, mix homogeneously, grind to form 50 purposes Powder, then will in powder add 15 times of weight distilled water, reflux, extract, 45 minutes at 85 DEG C, so Rear standing is lowered the temperature, and is filtrated to get supernatant；
(3) Herba Schizonepetae obtained, and Rhizoma Et Radix Notopterygii, Radix Platycodonis and Mus are processed by supernatant adds step (1) Grass, boils 35 minutes, refluxes, then filter, obtain filtrate when boiling, and will add step (1) in filtrate The Radix Glycyrrhizae powder obtained, stirring mixing, obtain pharmaceutical preparation.
Embodiment 2
A kind of pharmaceutical preparation that can be used for Intensive Care Therapy respiratory system infection, including the component of following weight portion:
8 parts of Herba Ephedrae；The Radix Paeoniae Alba 5 parts；10 parts of Rhizoma Zingiberis Recens；Rhizoma Et Radix Notopterygii 6 parts；Radix Platycodonis 5 parts；Herba Schizonepetae 8 parts； Mus grass 5 parts；14 parts of Radix Glycyrrhizae.
The preparation method of this pharmaceutical preparation, comprises the steps:
(1) Herba Ephedrae is sieved, remove impurity, be placed in mill groove, grind loosen into fiber velvet-like；By the Radix Paeoniae Alba Being soaked in water to eighty per cant thoroughly, pull out, solarization is dried in the air, and profit to inside and outside humidity is uniform, section, then puts interior the stir-fry of pot To coke yellow, spray clear water is a little, takes out, dries；Take fresh ginger, clean, mash, squeeze extracting juice, Stand, divide the opaque taking precipitation, cold drying, obtain powder, then weigh；By Herba Schizonepetae cutting, put In pot, micro-stir-fry at 80 DEG C, taking-up cools；Radix Glycyrrhizae section is added cooked Mel and a little boiled water, mixes thoroughly After the most vexed, put fry in pot to buff and tack-free time, take out and dry in the air cool, grind to form 55 mesh powder；
(2) weigh step (1) obtain Herba Ephedrae, the Radix Paeoniae Alba, Rhizoma Zingiberis powder, mix homogeneously, grind to form 40 purposes Powder, then will in powder add 13 times of weight distilled water, reflux, extract, 40 minutes at 83 DEG C, so Rear standing is lowered the temperature, and is filtrated to get supernatant；
(3) Herba Schizonepetae obtained, and Rhizoma Et Radix Notopterygii, Radix Platycodonis and Mus are processed by supernatant adds step (1) Grass, boils 30 minutes, refluxes, then filter, obtain filtrate when boiling, and will add step (1) in filtrate The Radix Glycyrrhizae powder obtained, stirring mixing, obtain pharmaceutical preparation.
Embodiment 4
A kind of pharmaceutical preparation that can be used for Intensive Care Therapy respiratory system infection, including the component of following weight portion:
7 parts of Herba Ephedrae；The Radix Paeoniae Alba 7 parts；9 parts of Rhizoma Zingiberis Recens；Rhizoma Et Radix Notopterygii 7 parts；Radix Platycodonis 5 parts；Herba Schizonepetae 8 parts；Mus Grass 3 parts；15 parts of Radix Glycyrrhizae.
The preparation method of this pharmaceutical preparation, comprises the steps:
(1) Herba Ephedrae is sieved, remove impurity, be placed in mill groove, grind loosen into fiber velvet-like；By the Radix Paeoniae Alba Being soaked in water to eighty per cant thoroughly, pull out, solarization is dried in the air, and profit to inside and outside humidity is uniform, section, then puts interior the stir-fry of pot To coke yellow, spray clear water is a little, takes out, dries；Take fresh ginger, clean, mash, squeeze extracting juice, Stand, divide the opaque taking precipitation, cold drying, obtain powder, then weigh；By Herba Schizonepetae cutting, put In pot, micro-stir-fry at 70 DEG C, taking-up cools；Radix Glycyrrhizae section is added cooked Mel and a little boiled water, mixes thoroughly After the most vexed, put fry in pot to buff and tack-free time, take out and dry in the air cool, grind to form 55 mesh powder；
(2) weigh step (1) obtain Herba Ephedrae, the Radix Paeoniae Alba, Rhizoma Zingiberis powder, mix homogeneously, grind to form 45 purposes Powder, then will in powder add 12 times of weight distilled water, reflux, extract, 40 minutes at 82 DEG C, so Rear standing is lowered the temperature, and is filtrated to get supernatant；
(3) Herba Schizonepetae obtained, and Rhizoma Et Radix Notopterygii, Radix Platycodonis and Mus are processed by supernatant adds step (1) Grass, boils 25 minutes, refluxes, then filter, obtain filtrate when boiling, and will add step (1) in filtrate The Radix Glycyrrhizae powder obtained, stirring mixing, obtain pharmaceutical preparation.
Embodiment 5
A kind of pharmaceutical preparation that can be used for Intensive Care Therapy respiratory system infection, including the component of following weight portion:
9 parts of Herba Ephedrae；The Radix Paeoniae Alba 5 parts；10 parts of Rhizoma Zingiberis Recens；Rhizoma Et Radix Notopterygii 5 parts；Radix Platycodonis 7 parts；Herba Schizonepetae 8 parts；Mus Grass 5 parts；13 parts of Radix Glycyrrhizae.
The preparation method of this pharmaceutical preparation, comprises the steps:
(1) Herba Ephedrae is sieved, remove impurity, be placed in mill groove, grind loosen into fiber velvet-like；By the Radix Paeoniae Alba Being soaked in water to eighty per cant thoroughly, pull out, solarization is dried in the air, and profit to inside and outside humidity is uniform, section, then puts interior the stir-fry of pot To coke yellow, spray clear water is a little, takes out, dries；Take fresh ginger, clean, mash, squeeze extracting juice, Stand, divide the opaque taking precipitation, cold drying, obtain powder, then weigh；By Herba Schizonepetae cutting, put In pot, micro-stir-fry at 70-90 DEG C, taking-up cools；Radix Glycyrrhizae section is added cooked Mel and a little boiled water, mixes After even the most vexed, put fry in pot to buff and tack-free time, take out and dry in the air cool, grind to form 55 mesh powder；
(2) weigh step (1) obtain Herba Ephedrae, the Radix Paeoniae Alba, Rhizoma Zingiberis powder, mix homogeneously, grind to form 40 purposes Powder, then will in powder add 15 times of weight distilled water, reflux, extract, 30-45 minute at 80 DEG C, Then stand cooling, be filtrated to get supernatant；
(3) Herba Schizonepetae obtained, and Rhizoma Et Radix Notopterygii, Radix Platycodonis and Mus are processed by supernatant adds step (1) Grass, boils 35 minutes, refluxes, then filter, obtain filtrate when boiling, and will add step (1) in filtrate The Radix Glycyrrhizae powder obtained, stirring mixing, obtain pharmaceutical preparation.
Treatment embodiment 1
Grandson so-and-so, man, 35 years old, admission number 8073
Examination in hospital belongs to Intensive Care Therapy respiratory system infection.Generate heat 7 days, body temperature at about 38 DEG C, antiperspirant Going out heat not understand, mouth is thirsty, headache, aversion to cold, micro-coughs, uncomfortable in chest, arthralgia, floating pulse taut band number, tongue fur Bao Bai.Blood routine examination: leukocyte 10.4 × 10 ↑ 9/L, neutrophilia 0.67.Fluoroscopy of chest: hilus pulumonis is cloudy Shadow increases deep, and non-activity sexually transmitted disease (STD) stove finds.
On the basis of carrying out conventional therapy, follow the doctor's advice, take the pharmaceutical preparation that the present invention provides, every day 3 Secondary, each take 55ml, after taking, drink the warm water of 150ml again, about 11 days, the state of an illness was clearly better.
Treatment embodiment 2
Guo so-and-so, female, 15 years old, recurrent cough 2 months, rise morning and cough very, abundant expectoration color is white, the most extremely Flu 1 time, receives stagnant less, and pallor is simple and unadorned, night sweat, the difficultest yellow urine, white and greasy fur, soft and thready pulse.Once with many Planting antibiotic therapy invalid, have a blood test Lactoferrin 112g/L, blood WBC 6300, N 0.54, L 0.46, rabat Prompting: increased bronchovascular shadows, C3b 7.5%, CIC 2.8%.Diagnosis belongs to Intensive Care Therapy respiratory system infection.
On the basis of carrying out conventional therapy, follow the doctor's advice, take the pharmaceutical preparation that the present invention provides, every day 3 Secondary, each take 35ml, after taking, drink the warm water of 100ml again, about 15 days, the state of an illness was clearly better. Check hemoglobin 125g/L, C3b 15.0%, CIC 2.5%.Rabat no abnormality seen.
The ultimate principle of the present invention and principal character and advantages of the present invention have more than been shown and described.The industry Skilled person will appreciate that, the present invention is not restricted to the described embodiments, in above-described embodiment and description The principle that the present invention is simply described described, without departing from the spirit and scope of the present invention, the present invention Also having various changes and modifications, these changes and improvements both fall within scope of the claimed invention.This The claimed scope of invention is defined by appending claims and equivalent thereof.

Claims (3)

1. the pharmaceutical preparation that can be used for Intensive Care Therapy respiratory system infection, it is characterised in that: include as follows The component of weight portion:
Herba Ephedrae 7-9 part；
Radix Paeoniae Alba 5-7 part；
Rhizoma Zingiberis Recens 9-11 part；
Rhizoma Et Radix Notopterygii 5-7 part；
Radix Platycodonis 3-7 part；
Herba Schizonepetae 7-9 part；
Mus grass 3-5 part；
Radix Glycyrrhizae 13-15 part.
A kind of pharmaceutical preparation that can be used for Intensive Care Therapy respiratory system infection the most according to claim 1, It is characterized in that: be prepared from by the component of following weight portion:
8 parts of Herba Ephedrae；
The Radix Paeoniae Alba 5 parts；
10 parts of Rhizoma Zingiberis Recens；
Rhizoma Et Radix Notopterygii 6 parts；
Radix Platycodonis 5 parts；
Herba Schizonepetae 8 parts；
Mus grass 5 parts；
14 parts of Radix Glycyrrhizae.
3. the method preparing pharmaceutical preparation as claimed in claim 1, it is characterised in that: include walking as follows Rapid:
(1) Herba Ephedrae is sieved, remove impurity, be placed in mill groove, grind loosen into fiber velvet-like；By the Radix Paeoniae Alba Being soaked in water to eighty per cant thoroughly, pull out, solarization is dried in the air, and profit to inside and outside humidity is uniform, section, then puts interior the stir-fry of pot To coke yellow, spray clear water is a little, takes out, dries；Take fresh ginger, clean, mash, squeeze extracting juice, Stand, divide the opaque taking precipitation, cold drying, obtain powder, then weigh；By Herba Schizonepetae cutting, put In pot, micro-stir-fry at 70-90 DEG C, taking-up cools；Radix Glycyrrhizae section is added cooked Mel and a little boiled water, mixes After even the most vexed, put fry in pot to buff and tack-free time, take out and dry in the air cool, grind to form 50-60 mesh powder；
(2) weigh step (1) obtain Herba Ephedrae, the Radix Paeoniae Alba, Rhizoma Zingiberis powder, mix homogeneously, grind to form 30-50 Purpose powder, then will add the distilled water of 10-15 times of weight, reflux, extract, at 80-85 DEG C in powder 30-45 minute, then stand cooling, be filtrated to get supernatant；
(3) Herba Schizonepetae obtained, and Rhizoma Et Radix Notopterygii, Radix Platycodonis and Mus are processed by supernatant adds step (1) Grass, boils 20-35 minute, refluxes, then filter, obtain filtrate when boiling, and will add step (1) in filtrate The Radix Glycyrrhizae powder obtained, stirring mixing, obtain pharmaceutical preparation.
CN201610521125.8A 2016-07-02 2016-07-02 Medicine preparation for treating intensive care respiratory system infection and preparation method thereof Pending CN105944070A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN201610521125.8A CN105944070A (en) 2016-07-02 2016-07-02 Medicine preparation for treating intensive care respiratory system infection and preparation method thereof

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN201610521125.8A CN105944070A (en) 2016-07-02 2016-07-02 Medicine preparation for treating intensive care respiratory system infection and preparation method thereof

Publications (1)

Publication Number Publication Date
CN105944070A true CN105944070A (en) 2016-09-21

Family

ID=56903399

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201610521125.8A Pending CN105944070A (en) 2016-07-02 2016-07-02 Medicine preparation for treating intensive care respiratory system infection and preparation method thereof

Country Status (1)

Country Link
CN (1) CN105944070A (en)

Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101979085A (en) * 2010-11-05 2011-02-23 刘志稳 Medicament for treating cough and asthma diseases
CN101147788B (en) * 2007-04-11 2011-05-11 秦庆吉 Medicine for treating cold and upper respiratory tract infection and its lung inflammation
CN101049424B (en) * 2006-04-03 2012-01-18 湖南中达骛马制药有限责任公司 Medication for treating infection in respiratory system
CN103920080A (en) * 2014-04-29 2014-07-16 周云飞 Traditional Chinese medicine for treating acute and chronic bronchitis
CN104435482A (en) * 2014-10-09 2015-03-25 张伟 Traditional Chinese medicine thick paste for preventing and treating respiratory tract infections and preparation method
CN104548047A (en) * 2015-01-29 2015-04-29 曹谦 Spray for treating respiratory system diseases
CN104826072A (en) * 2015-05-25 2015-08-12 苗怡文 Traditional Chinese medicine preparation for treating respiratory system infection and preparation method of traditional Chinese medicine preparation
CN105288285A (en) * 2015-11-12 2016-02-03 南京正亮医药科技有限公司 Medicinal preparation for treating chronic bronchitis

Patent Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101049424B (en) * 2006-04-03 2012-01-18 湖南中达骛马制药有限责任公司 Medication for treating infection in respiratory system
CN101147788B (en) * 2007-04-11 2011-05-11 秦庆吉 Medicine for treating cold and upper respiratory tract infection and its lung inflammation
CN101979085A (en) * 2010-11-05 2011-02-23 刘志稳 Medicament for treating cough and asthma diseases
CN103920080A (en) * 2014-04-29 2014-07-16 周云飞 Traditional Chinese medicine for treating acute and chronic bronchitis
CN104435482A (en) * 2014-10-09 2015-03-25 张伟 Traditional Chinese medicine thick paste for preventing and treating respiratory tract infections and preparation method
CN104548047A (en) * 2015-01-29 2015-04-29 曹谦 Spray for treating respiratory system diseases
CN104826072A (en) * 2015-05-25 2015-08-12 苗怡文 Traditional Chinese medicine preparation for treating respiratory system infection and preparation method of traditional Chinese medicine preparation
CN105288285A (en) * 2015-11-12 2016-02-03 南京正亮医药科技有限公司 Medicinal preparation for treating chronic bronchitis

Similar Documents

Publication Publication Date Title
KR20230002351A (en) Antibacterial and antiviral pharmaceutical composition and use thereof
CN1947754B (en) Medicine for treating infantile asthma and its preparation method
US20150283072A1 (en) Pre-operative beverages
CN104208245B (en) Tinea manus and pedis Traditional Chinese medicine medicated bath and preparation method
CN114246925A (en) Traditional Chinese medicine essential oil and application thereof
CN102258751A (en) Traditional Chinese medicine composition mint for treating melancholia, dispelling melancholy and relieving depression
CN1251732C (en) Chinese medicine for treating intrapulmonic infection and SARS
CN1785024A (en) Bag-tea for treating pharyngitis and beneficial for throat
KR20040041865A (en) herb medicine for remedying cold
CN106806758A (en) A kind of Chinese medicine preparation for treating acne
CN105169339A (en) Traditional Chinese medicine cleaning fluid for treating gynecologic inflammation
CN105381310A (en) Traditional Chinese medicine preparation for treating phthisis and preparing method thereof
CN109549958A (en) The composition and preparation method thereof for treating steroid dependent dermatitis
TW202330006A (en) Composition for preventing, improving or alleviating symptoms relating to qi deficiency and/or blood deficiency
CN105944070A (en) Medicine preparation for treating intensive care respiratory system infection and preparation method thereof
CN105343840A (en) Traditional Chinese medicine for treating pneumonia for traditional Chinese medicine internal medicine department
CN106075229A (en) A kind of Chinese medicinal composition preparation treating anemopyretic cold
CN1931229B (en) Medicine for treating acute and chronic nasopharyngitis and its preparation process
CN105560984B (en) Traditional Chinese medicine composition capable of boosting qi and invigorating spleen
CN105169149A (en) Traditional Chinese medicine composition for treating pyrophlegm stasis accumulation type thyroid cancer, preparation method and application
CN103860976B (en) A kind of pharmaceutical composition for the treatment of infant&#39;s dermatitis
CN104225344A (en) Chinese herbal preparation for treating chronic nephropyelitis and preparation method thereof
Dhar et al. Medicinal Plants of India
CN106074824A (en) Enhancing immunity and the compositions of prophylactic treatment influenza, preparation technology and purposes
JP2001139487A (en) Medicinal composition of nasal spray or nasal liquid medicine for pyrogenic common cold and method for producing the same

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
RJ01 Rejection of invention patent application after publication

Application publication date: 20160921

RJ01 Rejection of invention patent application after publication